KRT6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.67228970
2keratinocyte differentiation (GO:0030216)8.50216264
3intermediate filament cytoskeleton organization (GO:0045104)8.08025046
4epidermis development (GO:0008544)7.95924611
5intermediate filament-based process (GO:0045103)7.82322444
6skin morphogenesis (GO:0043589)7.42751674
7fatty acid elongation (GO:0030497)7.04671471
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.96999727
9multicellular organismal water homeostasis (GO:0050891)6.84516916
10epidermal cell differentiation (GO:0009913)6.31685673
11water homeostasis (GO:0030104)5.67528325
12response to zinc ion (GO:0010043)5.48844474
13regulation of keratinocyte proliferation (GO:0010837)5.43029425
14chemical homeostasis within a tissue (GO:0048875)5.10661005
15cell-substrate junction assembly (GO:0007044)4.72834688
16keratinocyte development (GO:0003334)4.52883346
17long-chain fatty acid biosynthetic process (GO:0042759)4.09584016
18long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.95021605
19polarized epithelial cell differentiation (GO:0030859)3.92832063
20adhesion of symbiont to host cell (GO:0044650)3.92751304
21virion attachment to host cell (GO:0019062)3.92751304
22gap junction assembly (GO:0016264)3.91404488
23skin development (GO:0043588)3.90773640
24* ectoderm development (GO:0007398)3.82896670
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.81593593
26cell adhesion mediated by integrin (GO:0033627)3.78638578
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.77052829
28negative regulation of keratinocyte proliferation (GO:0010839)3.73750911
29negative regulation of interferon-gamma production (GO:0032689)3.69589630
30epithelial cell differentiation involved in prostate gland development (GO:0060742)3.67989834
31positive regulation of monocyte chemotaxis (GO:0090026)3.67919224
32fatty-acyl-CoA biosynthetic process (GO:0046949)3.65921880
33epithelium development (GO:0060429)3.59746617
34lateral sprouting from an epithelium (GO:0060601)3.56368121
35phosphatidylinositol acyl-chain remodeling (GO:0036149)3.43097308
36endodermal cell differentiation (GO:0035987)3.41085701
37positive regulation of keratinocyte differentiation (GO:0045618)3.38898161
38adhesion of symbiont to host (GO:0044406)3.31796040
39keratinocyte proliferation (GO:0043616)3.22507990
40regulation of transforming growth factor beta2 production (GO:0032909)3.20824456
41regulation of keratinocyte differentiation (GO:0045616)3.16069653
42fatty-acyl-CoA metabolic process (GO:0035337)3.15242123
43regulation of transforming growth factor beta1 production (GO:0032908)3.10060604
44mesodermal cell differentiation (GO:0048333)3.09446804
45negative regulation of interleukin-17 production (GO:0032700)3.08356459
46negative regulation of epidermis development (GO:0045683)3.06813880
47very long-chain fatty acid metabolic process (GO:0000038)3.06044432
48ventricular cardiac muscle cell action potential (GO:0086005)3.03057059
49atrioventricular valve morphogenesis (GO:0003181)3.02604683
50negative regulation of chondrocyte differentiation (GO:0032331)3.02295901
51cellular response to interleukin-4 (GO:0071353)3.01723829
52keratinization (GO:0031424)21.8212989
53hair cycle (GO:0042633)20.1188069
54molting cycle (GO:0042303)20.1188069
55negative regulation of cell fate specification (GO:0009996)2.98444315
56hypotonic response (GO:0006971)2.97651555
57fibrinolysis (GO:0042730)2.96911887
58phosphatidylserine acyl-chain remodeling (GO:0036150)2.96516999
59regulation of monocyte chemotaxis (GO:0090025)2.96453556
60detection of bacterium (GO:0016045)2.91224698
61gland morphogenesis (GO:0022612)2.90727350
62cytoskeletal anchoring at plasma membrane (GO:0007016)2.86099403
63phosphatidylcholine acyl-chain remodeling (GO:0036151)2.81775097
64acyl-CoA biosynthetic process (GO:0071616)2.80479385
65thioester biosynthetic process (GO:0035384)2.80479385
66hair cycle process (GO:0022405)2.78557696
67molting cycle process (GO:0022404)2.78557696
68positive regulation of epidermis development (GO:0045684)2.76318099
69regulation of epidermal cell differentiation (GO:0045604)2.76146685
70linoleic acid metabolic process (GO:0043651)2.74864567
71renal filtration (GO:0097205)2.74149723
72regulation of T cell chemotaxis (GO:0010819)2.66028291
73positive regulation of T cell chemotaxis (GO:0010820)2.66028291
74regulation of cardioblast differentiation (GO:0051890)2.63729251
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62809666
76regulation of protein localization to cell surface (GO:2000008)2.60190469
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58473436
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58473436
79sequestering of metal ion (GO:0051238)2.56923938
80response to interleukin-4 (GO:0070670)2.56893871
81cell communication involved in cardiac conduction (GO:0086065)2.55883928
82positive regulation of epidermal cell differentiation (GO:0045606)2.55528716
83regulation of transforming growth factor beta production (GO:0071634)2.53823091
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.53800587
85detection of other organism (GO:0098543)2.53796638
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53332096
87intestinal epithelial cell development (GO:0060576)2.52441967
88regulation of heart rate by cardiac conduction (GO:0086091)2.50600007
89epithelial cell-cell adhesion (GO:0090136)2.45500688
90epithelial cell proliferation (GO:0050673)2.45457671
91cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.44059874
92extracellular matrix disassembly (GO:0022617)2.43316855
93cardiac muscle cell action potential involved in contraction (GO:0086002)2.39541357
94amyloid precursor protein metabolic process (GO:0042982)2.39107239
95cardiac right ventricle morphogenesis (GO:0003215)2.38730327
96wound healing (GO:0042060)2.36478486
97establishment of planar polarity (GO:0001736)2.36261103
98establishment of tissue polarity (GO:0007164)2.36261103
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34882280
100vitamin A metabolic process (GO:0006776)2.31532875
101hormone catabolic process (GO:0042447)2.29539417
102eyelid development in camera-type eye (GO:0061029)2.25933403
103phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.25694223
104citrulline biosynthetic process (GO:0019240)2.23287858
105phospholipid efflux (GO:0033700)2.21111075
106protein localization to endosome (GO:0036010)2.19214412
107surfactant homeostasis (GO:0043129)2.19132213
108regulation of epidermis development (GO:0045682)2.18054468
109antigen processing and presentation of endogenous antigen (GO:0019883)2.16593390
110phosphatidylserine metabolic process (GO:0006658)2.16224773
111hair follicle morphogenesis (GO:0031069)2.16146933
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.15594329
113epithelial cell differentiation (GO:0030855)2.14232683
114positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.13661393
115regulation of ruffle assembly (GO:1900027)2.12950119
116cell junction organization (GO:0034330)2.09279615
117positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.09059353
118interleukin-1-mediated signaling pathway (GO:0070498)2.06537486
119positive regulation of hair follicle development (GO:0051798)2.06107873
120positive regulation of hair cycle (GO:0042635)2.06107873
121regulation of hair cycle (GO:0042634)2.05826049
122positive regulation of protein export from nucleus (GO:0046827)2.03657679
123renal absorption (GO:0070293)2.02475209
124one-carbon compound transport (GO:0019755)2.02354097
125lipoxygenase pathway (GO:0019372)2.01942148
126cell junction assembly (GO:0034329)2.01454621
127regulation of natural killer cell differentiation (GO:0032823)2.00291699
128hemidesmosome assembly (GO:0031581)13.9631105
129desmosome organization (GO:0002934)12.8597247
130establishment of skin barrier (GO:0061436)11.8959214
131intermediate filament organization (GO:0045109)10.7329317
132regulation of water loss via skin (GO:0033561)10.4135506
133negative regulation of cell fate commitment (GO:0010454)1.99293037
134cardiac conduction (GO:0061337)1.98630067
135regulation of hair follicle development (GO:0051797)1.98495021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.05505908
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45835319
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.84942750
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.68648714
5EGR1_19032775_ChIP-ChIP_M12_Human2.44148796
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05208544
7TP63_17297297_ChIP-ChIP_HaCaT_Human16.4336024
8* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91448335
9* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91448335
10SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75651069
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.72446075
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60149359
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60035920
14ATF3_27146783_Chip-Seq_COLON_Human1.56884585
15ZNF263_19887448_ChIP-Seq_K562_Human1.51522473
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.51081053
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46122247
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.44569463
19RACK7_27058665_Chip-Seq_MCF-7_Human1.41623302
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.37558498
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35973223
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35631273
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30226281
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26058711
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25182254
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24775709
27SOX2_20726797_ChIP-Seq_SW620_Human1.24449699
28TP63_22573176_ChIP-Seq_HFKS_Human1.23824775
29LXR_22292898_ChIP-Seq_THP-1_Human1.23519783
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22942069
31* E2F1_20622854_ChIP-Seq_HELA_Human1.22878270
32CLOCK_20551151_ChIP-Seq_293T_Human1.21998916
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18303537
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17743490
35TP63_23658742_ChIP-Seq_EP156T_Human1.17086067
36GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16770618
37P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16619354
38CTCF_20526341_ChIP-Seq_ESCs_Human1.15915223
39ERG_20517297_ChIP-Seq_VCAP_Human1.12604144
40CTCF_27219007_Chip-Seq_Bcells_Human1.12530281
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10212654
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.07010167
43* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04527514
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.04106883
45RXR_22108803_ChIP-Seq_LS180_Human1.03491222
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01252209
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00895872
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00813173
49KLF5_25053715_ChIP-Seq_YYC3_Human1.00598039
50GATA6_21074721_ChIP-Seq_CACO-2_Human0.99679209
51ELK3_25401928_ChIP-Seq_HUVEC_Human0.99358643
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97373081
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95233406
54TCF4_18268006_ChIP-ChIP_LS174T_Human0.95209045
55CJUN_26792858_Chip-Seq_BT549_Human0.94884439
56SA1_27219007_Chip-Seq_ERYTHROID_Human0.93089675
57BCL6_27268052_Chip-Seq_Bcells_Human0.92886399
58P68_20966046_ChIP-Seq_HELA_Human0.92064893
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91520099
60* BCOR_27268052_Chip-Seq_Bcells_Human0.90993479
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90621131
62ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88346470
63SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88282273
64GATA2_21666600_ChIP-Seq_HMVEC_Human0.86097561
65P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84792250
66RUNX1_27514584_Chip-Seq_MCF-7_Human0.84729861
67KDM2B_26808549_Chip-Seq_DND41_Human0.84728149
68ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84045430
69CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83242187
70ERG_21242973_ChIP-ChIP_JURKAT_Human0.82717865
71YY1_22570637_ChIP-Seq_MALME-3M_Human0.80651329
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79882362
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79582263
74SMC4_20622854_ChIP-Seq_HELA_Human0.79129866
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78958344
76RAC3_21632823_ChIP-Seq_H3396_Human0.78768337
77BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78708671
78SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77853017
79* TAF2_19829295_ChIP-Seq_ESCs_Human0.77841264
80SPI1_20517297_ChIP-Seq_HL60_Human0.77660783
81* NANOG_20526341_ChIP-Seq_ESCs_Human0.77634728
82TP53_18474530_ChIP-ChIP_U2OS_Human0.77554899
83AHR_22903824_ChIP-Seq_MCF-7_Human0.75346353
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75179522
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.74942481
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73935972
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73671323
88PPARA_22158963_ChIP-Seq_LIVER_Mouse0.71653204
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70919184
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70877062
91KDM2B_26808549_Chip-Seq_K562_Human0.70053309
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.69578638
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69173059
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.69167632
95AR_21572438_ChIP-Seq_LNCaP_Human0.68991502
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.68638086
97TBX20_22080862_ChIP-Seq_HEART_Mouse0.68582487
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.68582487
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68330884
100CEBPB_22108803_ChIP-Seq_LS180_Human0.68221637
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66845507
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66228564
103TP53_16413492_ChIP-PET_HCT116_Human0.65991472
104* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65982596
105GATA6_25053715_ChIP-Seq_YYC3_Human0.65950666
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.65885100
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.65834269
108RXR_22158963_ChIP-Seq_LIVER_Mouse0.65093219
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.64452066
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.64258962
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.62661664
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.62660477
113GATA4_25053715_ChIP-Seq_YYC3_Human0.62170285
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.61439369
115ELK4_26923725_Chip-Seq_MESODERM_Mouse0.60713557
116GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60237962
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.59869798
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.59136292
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57293286
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.55928127
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.55229917
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.54111294
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.53916771
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.52706527
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.51864810
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.49071077
127TP53_22127205_ChIP-Seq_IMR90_Human0.48781219
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.47697055
129RBPJ_21746931_ChIP-Seq_IB4_Human0.47413138
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.47117721
131BRD4_25478319_ChIP-Seq_HGPS_Human0.46970387
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.46906769
133HTT_18923047_ChIP-ChIP_STHdh_Human0.46100859
134GATA1_22025678_ChIP-Seq_K562_Human0.43593343
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.43262222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.09833346
2* MP0000579_abnormal_nail_morphology7.41373442
3MP0005275_abnormal_skin_tensile5.91718986
4MP0005501_abnormal_skin_physiology5.02879423
5MP0004381_abnormal_hair_follicle4.24646917
6MP0000383_abnormal_hair_follicle3.95153160
7* MP0000467_abnormal_esophagus_morphology3.78699651
8MP0010234_abnormal_vibrissa_follicle3.70859143
9MP0005409_darkened_coat_color3.51290870
10MP0010678_abnormal_skin_adnexa3.45349166
11MP0003705_abnormal_hypodermis_morpholog3.33152505
12* MP0001216_abnormal_epidermal_layer3.30895687
13MP0003453_abnormal_keratinocyte_physiol3.27397753
14MP0010771_integument_phenotype3.02622595
15MP0002060_abnormal_skin_morphology2.91867625
16MP0004947_skin_inflammation2.63955445
17MP0000377_abnormal_hair_follicle2.55521091
18MP0000647_abnormal_sebaceous_gland2.53747536
19* MP0000762_abnormal_tongue_morphology2.15345284
20MP0002098_abnormal_vibrissa_morphology2.15071178
21MP0000427_abnormal_hair_cycle2.12889749
22MP0003566_abnormal_cell_adhesion2.07405573
23MP0002254_reproductive_system_inflammat2.06138683
24MP0003941_abnormal_skin_development1.96952935
25MP0009931_abnormal_skin_appearance1.72646810
26MP0002234_abnormal_pharynx_morphology1.71754065
27MP0005451_abnormal_body_composition1.68138178
28MP0005023_abnormal_wound_healing1.55093676
29MP0001191_abnormal_skin_condition1.52146641
30MP0004185_abnormal_adipocyte_glucose1.49284581
31MP0008438_abnormal_cutaneous_collagen1.48179316
32MP0003191_abnormal_cellular_cholesterol1.43355558
33MP0001243_abnormal_dermal_layer1.38923572
34* MP0000367_abnormal_coat/_hair1.37330817
35MP0009053_abnormal_anal_canal1.36199787
36MP0008260_abnormal_autophagy1.23613171
37MP0001849_ear_inflammation1.19833161
38MP0001851_eye_inflammation1.19081580
39MP0000465_gastrointestinal_hemorrhage1.17101928
40MP0003878_abnormal_ear_physiology1.11229415
41MP0005377_hearing/vestibular/ear_phenot1.11229415
42MP0002282_abnormal_trachea_morphology1.07415850
43MP0000678_abnormal_parathyroid_gland1.04985134
44MP0004885_abnormal_endolymph0.98587470
45MP0004264_abnormal_extraembryonic_tissu0.89524815
46MP0000537_abnormal_urethra_morphology0.78929657
47MP0003011_delayed_dark_adaptation0.77094523
48MP0005257_abnormal_intraocular_pressure0.70790250
49MP0001188_hyperpigmentation0.67609390
50MP0003950_abnormal_plasma_membrane0.62615369
51MP0004272_abnormal_basement_membrane0.61706633
52MP0001784_abnormal_fluid_regulation0.61114012
53MP0010352_gastrointestinal_tract_polyps0.60488538
54MP0001340_abnormal_eyelid_morphology0.55559274
55MP0003315_abnormal_perineum_morphology0.55379990
56MP0003329_amyloid_beta_deposits0.49310080
57* MP0003755_abnormal_palate_morphology0.48692873
58MP0000858_altered_metastatic_potential0.48463258
59MP0008789_abnormal_olfactory_epithelium0.47844328
60MP0005360_urolithiasis0.47132923
61MP0001299_abnormal_eye_distance/0.46139868
62MP0005666_abnormal_adipose_tissue0.43843105
63MP0006054_spinal_hemorrhage0.43367387
64MP0003436_decreased_susceptibility_to0.43075836
65MP0004782_abnormal_surfactant_physiolog0.42732213
66MP0003045_fibrosis0.41017748
67MP0009379_abnormal_foot_pigmentation0.40954330
68MP0001346_abnormal_lacrimal_gland0.39187111
69MP0000604_amyloidosis0.37514219
70MP0005499_abnormal_olfactory_system0.36870509
71MP0005394_taste/olfaction_phenotype0.36870509
72MP0005193_abnormal_anterior_eye0.36387307
73MP0002090_abnormal_vision0.36152508
74MP0002896_abnormal_bone_mineralization0.35404523
75MP0002877_abnormal_melanocyte_morpholog0.33415984
76MP0005375_adipose_tissue_phenotype0.32000664
77MP0000538_abnormal_urinary_bladder0.31958316
78MP0000627_abnormal_mammary_gland0.31689627
79MP0003091_abnormal_cell_migration0.31055079
80MP0000569_abnormal_digit_pigmentation0.29543019
81MP0005197_abnormal_uvea_morphology0.29430656
82MP0003303_peritoneal_inflammation0.29187772
83MP0003300_gastrointestinal_ulcer0.28962620
84MP0004858_abnormal_nervous_system0.28304655
85MP0002111_abnormal_tail_morphology0.27961557
86MP0003448_altered_tumor_morphology0.27368943
87MP0000751_myopathy0.27260103
88MP0002089_abnormal_postnatal_growth/wei0.27187482
89MP0009780_abnormal_chondrocyte_physiolo0.27169425
90MP0001533_abnormal_skeleton_physiology0.26040784
91MP0000432_abnormal_head_morphology0.26007719
92MP0009840_abnormal_foam_cell0.25990472
93MP0002177_abnormal_outer_ear0.25872080
94MP0002095_abnormal_skin_pigmentation0.25288184
95MP0008569_lethality_at_weaning0.24674941
96MP0003075_altered_response_to0.24616916
97MP0000470_abnormal_stomach_morphology0.24532496
98MP0000462_abnormal_digestive_system0.24353079
99MP0001958_emphysema0.23154942
100MP0005248_abnormal_Harderian_gland0.22808563
101MP0006138_congestive_heart_failure0.22029612
102MP0005621_abnormal_cell_physiology0.21968451
103MP0001177_atelectasis0.21968238
104MP0002166_altered_tumor_susceptibility0.21861118
105MP0001765_abnormal_ion_homeostasis0.21567077
106MP0002133_abnormal_respiratory_system0.19998764
107MP0005388_respiratory_system_phenotype0.19998764
108MP0003828_pulmonary_edema0.19538854
109MP0005076_abnormal_cell_differentiation0.19203871
110MP0000343_altered_response_to0.18793908
111MP0003638_abnormal_response/metabolism_0.18643411
112MP0004197_abnormal_fetal_growth/weight/0.17863200
113MP0002697_abnormal_eye_size0.17749163
114MP0002233_abnormal_nose_morphology0.16470091
115MP0001542_abnormal_bone_strength0.16193689
116MP0004019_abnormal_vitamin_homeostasis0.15689967
117MP0003385_abnormal_body_wall0.14938744
118MP0000566_synostosis0.14540511
119MP0000733_abnormal_muscle_development0.14536359
120MP0008770_decreased_survivor_rate0.14523410
121MP0010368_abnormal_lymphatic_system0.14159684
122MP0005075_abnormal_melanosome_morpholog0.14074040
123MP0002006_tumorigenesis0.13953963
124MP0010030_abnormal_orbit_morphology0.12670863
125MP0000750_abnormal_muscle_regeneration0.11573526
126MP0004087_abnormal_muscle_fiber0.10454123

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)8.71592207
2Palmoplantar hyperkeratosis (HP:0000972)8.60946434
3Plantar hyperkeratosis (HP:0007556)8.17275772
4Palmar hyperkeratosis (HP:0010765)8.15386061
5Follicular hyperkeratosis (HP:0007502)7.94041591
6Onycholysis (HP:0001806)6.30891892
7Increased IgE level (HP:0003212)6.13009044
8Fragile nails (HP:0001808)6.12118619
9Milia (HP:0001056)6.10189192
10Hypotrichosis (HP:0001006)5.53985260
11Woolly hair (HP:0002224)5.23966735
12* Abnormal blistering of the skin (HP:0008066)4.83958632
13Nail dystrophy (HP:0008404)4.54698360
14Ridged nail (HP:0001807)4.28123544
15Right ventricular cardiomyopathy (HP:0011663)4.24585869
16Abnormality of secondary sexual hair (HP:0009888)4.11777735
17Abnormality of the axillary hair (HP:0100134)4.11777735
18Erythroderma (HP:0001019)3.97042893
19Pili torti (HP:0003777)3.92119962
20Erythema (HP:0010783)3.81192153
21* Laryngomalacia (HP:0001601)3.76621299
22Fatigable weakness (HP:0003473)3.47258651
23Abnormality of the neuromuscular junction (HP:0003398)3.47258651
24Congenital ichthyosiform erythroderma (HP:0007431)3.28192952
25* Palmoplantar keratoderma (HP:0000982)3.27570704
26Conjunctival hamartoma (HP:0100780)3.21411544
27* Corneal dystrophy (HP:0001131)3.18557546
28Atrophic scars (HP:0001075)3.06784974
29Hypohidrosis (HP:0000966)2.97067170
30Hypoplasia of dental enamel (HP:0006297)2.90918505
31* Anonychia (HP:0001798)2.88566766
32Selective tooth agenesis (HP:0001592)2.85501000
33Papilloma (HP:0012740)2.78917988
34Verrucae (HP:0200043)2.78917988
35Pterygium (HP:0001059)2.76470867
36* Hyperhidrosis (HP:0000975)2.73890397
37Corneal erosion (HP:0200020)2.68097855
38Absent hair (HP:0002298)2.67210567
39Gangrene (HP:0100758)2.63323129
40Ectropion (HP:0000656)2.53378225
41Abnormal hair laboratory examination (HP:0003328)2.43782210
42Hypoplastic labia majora (HP:0000059)2.41867068
43Popliteal pterygium (HP:0009756)2.36776191
44Sparse eyelashes (HP:0000653)2.33544623
45Neonatal onset (HP:0003623)2.30153829
46Pustule (HP:0200039)2.29345659
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26626467
48Advanced eruption of teeth (HP:0006288)2.25194496
49Natal tooth (HP:0000695)2.24433943
50* Carious teeth (HP:0000670)2.23382618
51Abnormality of the labia majora (HP:0012881)2.18648695
52Ventricular tachycardia (HP:0004756)2.10949332
53Ankyloglossia (HP:0010296)2.04943087
54Hamartoma of the eye (HP:0010568)2.03472190
55* Abnormality of the fingernails (HP:0001231)2.00591092
56* Abnormality of nail color (HP:0100643)15.0646297
57Thick nail (HP:0001805)12.1914763
58Oral leukoplakia (HP:0002745)10.0657365
59Pruritus (HP:0000989)1.99613232
60Lip pit (HP:0100267)1.98037347
61Hypergammaglobulinemia (HP:0010702)1.95611579
62Oligodontia (HP:0000677)1.94777074
63Hypodontia (HP:0000668)1.94152283
64Parakeratosis (HP:0001036)1.93675585
65Multifactorial inheritance (HP:0001426)1.87294431
66Curly hair (HP:0002212)1.87135515
67Skin ulcer (HP:0200042)1.80553495
68Recurrent corneal erosions (HP:0000495)1.78979848
69Keratoconjunctivitis sicca (HP:0001097)1.76090208
70Absent eyelashes (HP:0000561)1.74718607
71Epidermoid cyst (HP:0200040)1.73375227
72Blepharitis (HP:0000498)1.72486394
73Increased connective tissue (HP:0009025)1.72336514
74Lack of skin elasticity (HP:0100679)1.71711103
75Fragile skin (HP:0001030)1.69642453
76Xerostomia (HP:0000217)1.66175916
77Autoamputation (HP:0001218)1.64470630
78Type 1 muscle fiber predominance (HP:0003803)1.61731351
79Amniotic constriction ring (HP:0009775)1.61051590
80Abnormality of placental membranes (HP:0011409)1.61051590
81Fine hair (HP:0002213)1.58697549
82Amelogenesis imperfecta (HP:0000705)1.58606624
83Abnormality of oral frenula (HP:0000190)1.57300442
84Keratoconjunctivitis (HP:0001096)1.56560093
85Esophageal atresia (HP:0002032)1.53478412
86Septate vagina (HP:0001153)1.53266952
87Neurofibrillary tangles (HP:0002185)1.50989444
88Ventricular fibrillation (HP:0001663)1.47901059
89Hyporeflexia of lower limbs (HP:0002600)1.46294782
90Labial hypoplasia (HP:0000066)1.46121590
91Urticaria (HP:0001025)1.45130352
92Split foot (HP:0001839)1.44202010
93Squamous cell carcinoma (HP:0002860)1.42839445
94Round ear (HP:0100830)1.41073239
95Furrowed tongue (HP:0000221)1.40943314
96Abnormality of hair growth rate (HP:0011363)1.39917780
97Slow-growing hair (HP:0002217)1.39917780
98Cheilitis (HP:0100825)1.38727034
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.38129365
100Protrusio acetabuli (HP:0003179)1.37861808
101Breast hypoplasia (HP:0003187)1.37043284
102Muscle fiber splitting (HP:0003555)1.36015115
103Premature rupture of membranes (HP:0001788)1.35873966
104Achilles tendon contracture (HP:0001771)1.35868473
105Hoarse voice (HP:0001609)1.34805460
106Melanocytic nevus (HP:0000995)1.34703296
107Aplasia cutis congenita (HP:0001057)1.34405803
108Sudden death (HP:0001699)1.33544526
109Muscle fiber inclusion bodies (HP:0100299)1.33117894
110Recurrent bacterial skin infections (HP:0005406)1.33089981
111Hypoplastic female external genitalia (HP:0012815)1.32944037
112Brittle hair (HP:0002299)1.32783521
113Acanthosis nigricans (HP:0000956)1.32641741
114Abnormality of the gastric mucosa (HP:0004295)1.32263487
115Premature loss of primary teeth (HP:0006323)1.30754754
116Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.30172589
117Nemaline bodies (HP:0003798)1.28505811
118Abnormality of the Achilles tendon (HP:0005109)1.27570952
119Eczematoid dermatitis (HP:0000976)1.24320545
120Intention tremor (HP:0002080)1.23088301
121Peritonitis (HP:0002586)1.20467965
122Dry hair (HP:0011359)1.19663931
123Severe Myopia (HP:0011003)1.15705274
124Distal arthrogryposis (HP:0005684)1.14843393
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.13355951
126Osteolytic defects of the hand bones (HP:0009699)1.13355951
127Myopathic facies (HP:0002058)1.13293580
128Knee flexion contracture (HP:0006380)1.12805148
129Dehydration (HP:0001944)1.12216301
130Sparse scalp hair (HP:0002209)1.09266420
131Distal lower limb amyotrophy (HP:0008944)1.08934948
132Abnormality of the salivary glands (HP:0010286)1.08081676
133Calcaneovalgus deformity (HP:0001848)1.07228353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.77361928
2FER4.49810733
3TRIB33.49151889
4MST1R3.46617432
5ARAF3.40808318
6TGFBR13.33582340
7BLK2.55576152
8EPHB12.49220677
9TTN2.45900385
10EPHA22.30191865
11PIK3CG2.23039261
12FGFR42.21345076
13MAPKAPK32.19596641
14MAP3K32.19104939
15TYK22.14251474
16RPS6KA42.01854708
17MAP3K91.96271721
18EPHA31.95430740
19TAOK11.79282451
20EPHB21.73165152
21MAP3K61.73094259
22RIPK11.72337315
23MAP3K111.68398322
24MAP3K21.62541388
25PKN21.61021690
26LATS11.59474720
27TGFBR21.55429643
28MET1.50124004
29FLT31.48077167
30TESK11.44191511
31FGFR31.39779988
32PTK61.33782588
33DDR21.32763369
34FGFR11.30402978
35CDK121.28772034
36MAP3K11.27847131
37EEF2K1.27004497
38NME11.24039833
39LATS21.22733958
40MAP2K61.21333377
41PDGFRA1.18079544
42LRRK21.17618287
43LIMK11.12282340
44LMTK21.04829257
45JAK11.03622985
46TRPM71.02740617
47MAP2K31.00322029
48PTK20.99119113
49KSR20.97211474
50ERBB30.95082410
51BMX0.93605795
52MAP2K40.93059519
53BRAF0.92313436
54MAP2K10.90708713
55BCR0.90398516
56CDK60.88395162
57MST40.87293326
58STK38L0.84777628
59RPS6KB20.82120563
60STK380.80135404
61FGR0.79663239
62RAF10.79321054
63RPS6KA20.77469584
64OBSCN0.76108341
65MAPKAPK20.74938181
66STK240.73882884
67CSF1R0.70224445
68NEK60.69424608
69NEK10.69374254
70PAK20.67844169
71KIT0.67683948
72SMG10.67517866
73IKBKB0.67412854
74PRPF4B0.67361318
75CDC42BPA0.64983250
76MAP3K70.63203964
77RET0.63057825
78NTRK20.62763072
79JAK30.62038040
80ALK0.62014028
81JAK20.60611963
82WNK10.60451253
83PIM20.60349333
84TBK10.59417318
85PRKCI0.58758130
86STK100.54049463
87FGFR20.53143938
88DMPK0.51819052
89ILK0.51622791
90ADRBK10.49622840
91PRKD20.49314951
92MTOR0.48574562
93PRKD10.47913261
94IRAK30.46488550
95TYRO30.46097344
96RPS6KA10.45930347
97HCK0.45538008
98ABL20.44997274
99GRK60.44864658
100MAPK70.44773925
101STK30.44058162
102ERBB20.43643141
103RPS6KB10.42548954
104CSK0.42509140
105FYN0.42366070
106MAPK120.41711774
107SIK10.41563096
108PAK30.41247000
109MAPKAPK50.40964252
110PRKCE0.40764023
111IRAK10.40481506
112SGK2230.40010356
113SGK4940.40010356
114PHKG20.39465526
115PHKG10.39465526
116ROCK10.38220363
117SRC0.38059011
118ROCK20.37249955
119PAK60.36647751
120NTRK10.36462472
121MAP3K50.32639461
122GSK3A0.32264078
123CAMK1G0.32160017
124IKBKE0.31815686
125EGFR0.30842933
126MAPK40.30068445
127RPS6KL10.28497535
128RPS6KC10.28497535
129MAP3K120.27440948
130PRKCH0.27053077
131INSR0.26752392
132MATK0.26084617
133PDGFRB0.26016979
134PAK40.25575760
135SCYL20.25478225
136MAP3K80.25135371
137ABL10.24578322
138MOS0.24470884
139SGK30.23502912
140KSR10.23435230
141IGF1R0.22007069
142MYLK0.21976491

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.24638500
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18931304
3Linoleic acid metabolism_Homo sapiens_hsa005913.13210707
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28451603
5Caffeine metabolism_Homo sapiens_hsa002322.12575501
6ECM-receptor interaction_Homo sapiens_hsa045122.04927255
7Ether lipid metabolism_Homo sapiens_hsa005652.04562783
8Fat digestion and absorption_Homo sapiens_hsa049751.90344777
9Arachidonic acid metabolism_Homo sapiens_hsa005901.79976344
10Phenylalanine metabolism_Homo sapiens_hsa003601.76836946
11p53 signaling pathway_Homo sapiens_hsa041151.75994768
12VEGF signaling pathway_Homo sapiens_hsa043701.69281469
13Staphylococcus aureus infection_Homo sapiens_hsa051501.64169287
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59369363
15Steroid biosynthesis_Homo sapiens_hsa001001.52919836
16Amoebiasis_Homo sapiens_hsa051461.46626011
17ErbB signaling pathway_Homo sapiens_hsa040121.45452195
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43469552
19GnRH signaling pathway_Homo sapiens_hsa049121.42810867
20Histidine metabolism_Homo sapiens_hsa003401.41013894
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39513669
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29869765
23Pertussis_Homo sapiens_hsa051331.28089928
24Proteoglycans in cancer_Homo sapiens_hsa052051.26259429
25PPAR signaling pathway_Homo sapiens_hsa033201.26060678
26Toxoplasmosis_Homo sapiens_hsa051451.24100280
27Acute myeloid leukemia_Homo sapiens_hsa052211.21168519
28Nitrogen metabolism_Homo sapiens_hsa009101.21076743
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17687872
30Phototransduction_Homo sapiens_hsa047441.15186631
31Focal adhesion_Homo sapiens_hsa045101.14288780
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11504505
33Bladder cancer_Homo sapiens_hsa052191.05986683
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05450875
35Adherens junction_Homo sapiens_hsa045201.04995217
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02769850
37Long-term depression_Homo sapiens_hsa047300.99570218
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.98326944
39Dorso-ventral axis formation_Homo sapiens_hsa043200.97415153
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96914147
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95700972
42Notch signaling pathway_Homo sapiens_hsa043300.94500169
43Platelet activation_Homo sapiens_hsa046110.93697783
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93568481
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93315275
46Axon guidance_Homo sapiens_hsa043600.91478753
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91251099
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90608489
49Glioma_Homo sapiens_hsa052140.89825729
50Pathways in cancer_Homo sapiens_hsa052000.87745514
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84479943
52Dilated cardiomyopathy_Homo sapiens_hsa054140.83878410
53Endometrial cancer_Homo sapiens_hsa052130.83851785
54Chronic myeloid leukemia_Homo sapiens_hsa052200.83577125
55Inositol phosphate metabolism_Homo sapiens_hsa005620.83048821
56Sphingolipid metabolism_Homo sapiens_hsa006000.82294659
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81930184
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81161234
59Tight junction_Homo sapiens_hsa045300.81142016
60Pancreatic cancer_Homo sapiens_hsa052120.80623500
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79971053
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79207123
63Insulin signaling pathway_Homo sapiens_hsa049100.78742038
64Tyrosine metabolism_Homo sapiens_hsa003500.77030940
65Estrogen signaling pathway_Homo sapiens_hsa049150.75382917
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.74388411
67Salmonella infection_Homo sapiens_hsa051320.74054655
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.73479676
69Tuberculosis_Homo sapiens_hsa051520.73406451
70Malaria_Homo sapiens_hsa051440.73238998
71Retinol metabolism_Homo sapiens_hsa008300.72727557
72Serotonergic synapse_Homo sapiens_hsa047260.72527653
73Pancreatic secretion_Homo sapiens_hsa049720.72391587
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72389128
75Insulin resistance_Homo sapiens_hsa049310.70932027
76Gastric acid secretion_Homo sapiens_hsa049710.69035679
77Thyroid cancer_Homo sapiens_hsa052160.68601552
78Ras signaling pathway_Homo sapiens_hsa040140.67907169
79Complement and coagulation cascades_Homo sapiens_hsa046100.67591424
80Renin secretion_Homo sapiens_hsa049240.67455097
81Melanogenesis_Homo sapiens_hsa049160.67261911
82Renal cell carcinoma_Homo sapiens_hsa052110.64991679
83Hepatitis C_Homo sapiens_hsa051600.63918354
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.63655994
85beta-Alanine metabolism_Homo sapiens_hsa004100.62645038
86Long-term potentiation_Homo sapiens_hsa047200.61896927
87Prion diseases_Homo sapiens_hsa050200.61888146
88Shigellosis_Homo sapiens_hsa051310.60790192
89Endocytosis_Homo sapiens_hsa041440.60532178
90Small cell lung cancer_Homo sapiens_hsa052220.60513625
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60042046
92Oxytocin signaling pathway_Homo sapiens_hsa049210.58778398
93Osteoclast differentiation_Homo sapiens_hsa043800.58621083
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57615787
95Protein digestion and absorption_Homo sapiens_hsa049740.57172826
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.56690790
97Phagosome_Homo sapiens_hsa041450.56419109
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56163656
99TNF signaling pathway_Homo sapiens_hsa046680.55833713
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55545021
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.55494957
102ABC transporters_Homo sapiens_hsa020100.55311148
103MicroRNAs in cancer_Homo sapiens_hsa052060.54558848
104Salivary secretion_Homo sapiens_hsa049700.54048561
105Melanoma_Homo sapiens_hsa052180.54009587
106Glycerolipid metabolism_Homo sapiens_hsa005610.53996057
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53869013
108Arginine biosynthesis_Homo sapiens_hsa002200.52747663
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.50853953
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50512208
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50275318
112Bile secretion_Homo sapiens_hsa049760.49395640
113Rap1 signaling pathway_Homo sapiens_hsa040150.49285358
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49010638
115Leishmaniasis_Homo sapiens_hsa051400.48976990
116Chemical carcinogenesis_Homo sapiens_hsa052040.48642985
117Non-small cell lung cancer_Homo sapiens_hsa052230.48623028
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47849043
119Hippo signaling pathway_Homo sapiens_hsa043900.47806577
120Apoptosis_Homo sapiens_hsa042100.47102255
121Gap junction_Homo sapiens_hsa045400.46977707
122TGF-beta signaling pathway_Homo sapiens_hsa043500.45336083
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44626074
124Antigen processing and presentation_Homo sapiens_hsa046120.44404848
125Prostate cancer_Homo sapiens_hsa052150.44146071
126Lysosome_Homo sapiens_hsa041420.43686546
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43039267
128Choline metabolism in cancer_Homo sapiens_hsa052310.42871661
129Ovarian steroidogenesis_Homo sapiens_hsa049130.42592365
130Basal cell carcinoma_Homo sapiens_hsa052170.42530826
131Glucagon signaling pathway_Homo sapiens_hsa049220.37152924
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37000241

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