KRT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.59755296
2Golgi transport vesicle coating (GO:0048200)7.59755296
3hemidesmosome assembly (GO:0031581)6.30350036
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.57805959
5cell-substrate junction assembly (GO:0007044)5.45382246
6endocrine pancreas development (GO:0031018)5.33542227
7hepatocyte apoptotic process (GO:0097284)5.21635291
8bundle of His cell to Purkinje myocyte communication (GO:0086069)5.16367989
9protein retention in ER lumen (GO:0006621)5.05367901
10mesodermal cell differentiation (GO:0048333)4.95898765
11surfactant homeostasis (GO:0043129)4.77354345
12glandular epithelial cell differentiation (GO:0002067)4.75221643
13polyketide metabolic process (GO:0030638)4.69768880
14doxorubicin metabolic process (GO:0044598)4.69768880
15daunorubicin metabolic process (GO:0044597)4.69768880
16protein maturation by protein folding (GO:0022417)4.60846317
17intestinal epithelial cell development (GO:0060576)4.58093324
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.37234700
19regulation of transforming growth factor beta2 production (GO:0032909)4.32531519
20aminoglycoside antibiotic metabolic process (GO:0030647)4.14990958
21interferon-gamma secretion (GO:0072643)4.06081398
22cell adhesion mediated by integrin (GO:0033627)4.03252137
23diterpenoid biosynthetic process (GO:0016102)3.98741130
24positive regulation of epidermal cell differentiation (GO:0045606)3.97414308
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.90609863
26establishment of skin barrier (GO:0061436)3.89869087
27tight junction assembly (GO:0070830)3.88557790
28columnar/cuboidal epithelial cell development (GO:0002066)3.86647074
29lung vasculature development (GO:0060426)3.86551330
30desmosome organization (GO:0002934)3.84591002
31positive regulation of keratinocyte differentiation (GO:0045618)3.81132945
32one-carbon compound transport (GO:0019755)3.80143556
33regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.77875713
34keratinocyte proliferation (GO:0043616)3.75507101
35COPII vesicle coating (GO:0048208)3.73195008
36sequestering of metal ion (GO:0051238)3.72854945
37regulation of type B pancreatic cell apoptotic process (GO:2000674)3.72394251
38multicellular organismal water homeostasis (GO:0050891)3.69519938
39protein localization to endosome (GO:0036010)3.69476934
40negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.69451315
41cell-substrate adherens junction assembly (GO:0007045)3.68665403
42focal adhesion assembly (GO:0048041)3.68665403
43membrane raft organization (GO:0031579)3.67741365
44peptide hormone processing (GO:0016486)3.63498076
45calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.62373965
46chemical homeostasis within a tissue (GO:0048875)3.57946196
47positive regulation of epidermis development (GO:0045684)3.55168615
48positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.54341578
49negative regulation of glycoprotein biosynthetic process (GO:0010561)3.51446985
50regulation of cardioblast proliferation (GO:0003264)3.49153990
51regulation of secondary heart field cardioblast proliferation (GO:0003266)3.49153990
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.47678740
53epithelial tube branching involved in lung morphogenesis (GO:0060441)3.46043107
54activation of Rac GTPase activity (GO:0032863)3.44743386
55regulation of apoptotic process involved in morphogenesis (GO:1902337)3.42969751
56negative regulation of keratinocyte proliferation (GO:0010839)3.38606502
57hypotonic response (GO:0006971)3.37881040
58protein autoprocessing (GO:0016540)3.36712404
59signal peptide processing (GO:0006465)3.35214466
60positive regulation of protein localization to plasma membrane (GO:1903078)3.33609983
61mitotic nuclear envelope reassembly (GO:0007084)3.33602573
62nuclear envelope reassembly (GO:0031468)3.33602573
63type B pancreatic cell development (GO:0003323)3.32481801
64negative regulation of chondrocyte differentiation (GO:0032331)3.31490768
65activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.31405764
66ear development (GO:0043583)3.31347987
67cellular response to vitamin D (GO:0071305)3.31338998
684-hydroxyproline metabolic process (GO:0019471)3.29387027
69regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.28167462
70skin morphogenesis (GO:0043589)3.27569564
71regulation of water loss via skin (GO:0033561)3.27511038
72adherens junction assembly (GO:0034333)3.27336337
73glandular epithelial cell development (GO:0002068)3.25964822
74ganglion development (GO:0061548)3.24432976
75embryonic foregut morphogenesis (GO:0048617)3.18671052
76pentose-phosphate shunt (GO:0006098)3.18598378
77positive regulation of hormone biosynthetic process (GO:0046886)3.18572804
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.18219012
79endoplasmic reticulum unfolded protein response (GO:0030968)3.16167326
80positive regulation of nuclease activity (GO:0032075)3.13221501
81hepatocyte differentiation (GO:0070365)3.12537788
82toxin metabolic process (GO:0009404)3.12338376
83glucose catabolic process (GO:0006007)3.12313953
84cellular response to unfolded protein (GO:0034620)3.11587213
85glial cell proliferation (GO:0014009)3.09116783
86thyroid hormone generation (GO:0006590)3.08350751
87decidualization (GO:0046697)3.06886085
88cyclooxygenase pathway (GO:0019371)3.04556260
89mammary gland epithelial cell proliferation (GO:0033598)3.04181307
90positive regulation of osteoblast proliferation (GO:0033690)3.03955700
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.03739228
92exocrine pancreas development (GO:0031017)3.02625725
93positive regulation of positive chemotaxis (GO:0050927)3.02405562
94gap junction assembly (GO:0016264)3.01828711
95pancreas development (GO:0031016)3.00753683
96membrane budding (GO:0006900)2.98936856
97lung epithelium development (GO:0060428)2.97724883
98cellular response to topologically incorrect protein (GO:0035967)2.96924794
99branching involved in mammary gland duct morphogenesis (GO:0060444)2.96470262
100peptide catabolic process (GO:0043171)2.93394177
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.91419787
102regulation of positive chemotaxis (GO:0050926)2.91009921
103protein localization to microtubule (GO:0035372)2.90933726
104positive regulation of glycoprotein metabolic process (GO:1903020)2.90907419
105regulation of keratinocyte proliferation (GO:0010837)2.90754184
106water homeostasis (GO:0030104)2.89525680
107ER-nucleus signaling pathway (GO:0006984)2.89035561
108nucleobase-containing small molecule interconversion (GO:0015949)2.88963363
109establishment of apical/basal cell polarity (GO:0035089)2.88599257
110morphogenesis of embryonic epithelium (GO:0016331)2.88584458
111regulation of interleukin-8 secretion (GO:2000482)2.87317268
112vesicle coating (GO:0006901)2.86465065
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.86114943
114regulation of cell fate specification (GO:0042659)2.85776525
115lung lobe morphogenesis (GO:0060463)2.85199416
116cell junction assembly (GO:0034329)2.84041086
117regulation of nuclease activity (GO:0032069)2.82749555
118O-glycan processing (GO:0016266)2.82068646
119maintenance of gastrointestinal epithelium (GO:0030277)2.81149932
120NADPH regeneration (GO:0006740)2.79554737
121renal filtration (GO:0097205)2.79507142
122regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77959496
123pyrimidine nucleoside salvage (GO:0043097)2.75692505
124pyrimidine-containing compound salvage (GO:0008655)2.75692505
125atrioventricular valve morphogenesis (GO:0003181)2.75449450
126epithelial cell-cell adhesion (GO:0090136)2.75009728
127positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74783369
128respiratory tube development (GO:0030323)2.74525064
129branching involved in salivary gland morphogenesis (GO:0060445)2.72558278
130muscle cell migration (GO:0014812)2.72143309
131signal transduction involved in regulation of gene expression (GO:0023019)2.71371453
132cell differentiation involved in embryonic placenta development (GO:0060706)2.71367659
133regulation of keratinocyte differentiation (GO:0045616)2.71189045
134prostaglandin biosynthetic process (GO:0001516)2.71064320
135prostanoid biosynthetic process (GO:0046457)2.71064320
136negative regulation of cell fate specification (GO:0009996)2.70885952
137terpenoid biosynthetic process (GO:0016114)2.70174316
138cell junction organization (GO:0034330)2.69256169
139ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.69117620
140positive regulation of insulin secretion (GO:0032024)2.68243035
141citrulline biosynthetic process (GO:0019240)2.67843346
142regulation of translational termination (GO:0006449)2.67188438
143prostanoid metabolic process (GO:0006692)2.66924178
144prostaglandin metabolic process (GO:0006693)2.66924178
145keratinocyte development (GO:0003334)2.65584657
146regulation of metalloenzyme activity (GO:0048552)2.64992176
147amyloid precursor protein metabolic process (GO:0042982)2.64432841
148membrane protein ectodomain proteolysis (GO:0006509)2.64191488
149ER overload response (GO:0006983)2.63468796
150renal absorption (GO:0070293)2.63134003
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.62886247
152response to endoplasmic reticulum stress (GO:0034976)2.62223194
153substrate-dependent cell migration (GO:0006929)2.61346981
154L-serine transport (GO:0015825)2.60897289
155cell-cell junction assembly (GO:0007043)2.60814059
156regulation of hippo signaling (GO:0035330)2.60495998
157wound healing, spreading of cells (GO:0044319)2.59653046
158regulation of hair follicle development (GO:0051797)2.59363810
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.59342696
160UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58961115
161positive regulation of vesicle fusion (GO:0031340)2.58870207
162semaphorin-plexin signaling pathway (GO:0071526)2.58720734
163cellular response to vitamin (GO:0071295)2.58655251
164endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.58237051
165cellular copper ion homeostasis (GO:0006878)2.57356903
166primary alcohol catabolic process (GO:0034310)2.56427697
167positive regulation of hair cycle (GO:0042635)2.56038113
168positive regulation of hair follicle development (GO:0051798)2.56038113
169actin filament bundle organization (GO:0061572)2.55677554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.68749627
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.26351440
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.24388992
4* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.90410193
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.71848049
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.70001328
7SOX2_27498859_Chip-Seq_STOMACH_Mouse3.25103443
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06578100
9ESR2_21235772_ChIP-Seq_MCF-7_Human3.02279205
10* SOX2_20726797_ChIP-Seq_SW620_Human2.80137929
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.62201257
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59293801
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52741023
14GATA4_25053715_ChIP-Seq_YYC3_Human2.47261844
15CLOCK_20551151_ChIP-Seq_293T_Human2.42740115
16SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.35936939
17* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.24245974
18* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.24245974
19GATA6_25053715_ChIP-Seq_YYC3_Human2.20416616
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.17098388
21* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.15447398
22* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.13008163
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.12502664
24* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09685140
25AR_21909140_ChIP-Seq_LNCAP_Human2.02404582
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.94557454
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92051509
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90539377
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88275373
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85007305
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82286324
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82147273
33* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81921087
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.81842517
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81777913
36GATA1_22025678_ChIP-Seq_K562_Human1.81703123
37* GATA2_21666600_ChIP-Seq_HMVEC_Human1.80970802
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.79581636
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76674911
40* RUNX1_27514584_Chip-Seq_MCF-7_Human1.75474854
41* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.71535534
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.70537520
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.70148347
44FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.65080059
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62874804
46* ATF3_27146783_Chip-Seq_COLON_Human1.62141528
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61968384
48E2F7_22180533_ChIP-Seq_HELA_Human1.58150209
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.53742456
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52894094
51* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52670216
52KLF5_25053715_ChIP-Seq_YYC3_Human1.51188469
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48908390
54* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45458006
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41387067
56EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.39704843
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38745916
58CJUN_26792858_Chip-Seq_BT549_Human1.37711915
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35125409
60* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34625768
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.34152956
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34028680
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33941081
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28144026
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27772375
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.27548409
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26800020
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26389762
69ZNF263_19887448_ChIP-Seq_K562_Human1.24181417
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20931416
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20506440
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20119224
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17501885
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16218200
75TP53_22127205_ChIP-Seq_IMR90_Human1.15894755
76* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15575736
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13972922
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11746198
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10765597
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09707227
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09224310
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09147869
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08203870
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07094513
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06991327
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.06968413
87CHD1_26751641_Chip-Seq_LNCaP_Human1.06484109
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06285017
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06141476
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.04189696
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03957336
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03208990
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02230005
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.02223422
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00926653
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99171418
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98999942
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97642614
99SMC4_20622854_ChIP-Seq_HELA_Human0.95152872
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94823509
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94797960
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94568684
103AHR_22903824_ChIP-Seq_MCF-7_Human0.93834085
104DCP1A_22483619_ChIP-Seq_HELA_Human0.93704803
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92415703
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89713808
107MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89679046
108* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89640854
109* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89493731
110ELF5_23300383_ChIP-Seq_T47D_Human0.89239614
111* LXR_22292898_ChIP-Seq_THP-1_Human0.88236993
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88129073
113E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86900526
114* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86389927
115TP63_23658742_ChIP-Seq_EP156T_Human0.86196055
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85859006
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.85829527
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.85829527
119* FOXA2_19822575_ChIP-Seq_HepG2_Human0.85445752
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84946411
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84946411
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.84218356
123MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82907398
124* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82744234
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82684959
126BRD4_25478319_ChIP-Seq_HGPS_Human0.81249892
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80427305
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78907403
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78867304
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.77780170
131GATA1_19941826_ChIP-Seq_K562_Human0.77575769
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.74486503
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73227913
134* TP63_22573176_ChIP-Seq_HFKS_Human0.72494247
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72470951
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71673180
137* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71396832
138* CREB1_26743006_Chip-Seq_LNCaP_Human0.69944680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.04631714
2MP0004264_abnormal_extraembryonic_tissu4.30926433
3MP0002877_abnormal_melanocyte_morpholog4.17039679
4MP0000537_abnormal_urethra_morphology3.76787898
5MP0002138_abnormal_hepatobiliary_system3.20302782
6MP0006054_spinal_hemorrhage3.13386112
7MP0002909_abnormal_adrenal_gland2.59023331
8MP0000462_abnormal_digestive_system2.54471176
9MP0010386_abnormal_urinary_bladder2.49017654
10MP0000678_abnormal_parathyroid_gland2.34497359
11MP0003283_abnormal_digestive_organ2.33402075
12MP0001944_abnormal_pancreas_morphology2.31871512
13MP0004272_abnormal_basement_membrane2.30604910
14MP0002234_abnormal_pharynx_morphology2.28359856
15MP0003300_gastrointestinal_ulcer2.23949593
16MP0002693_abnormal_pancreas_physiology2.16549764
17MP0000013_abnormal_adipose_tissue2.14330145
18MP0005623_abnormal_meninges_morphology2.09444940
19MP0005220_abnormal_exocrine_pancreas2.06925580
20MP0003566_abnormal_cell_adhesion2.06536008
21MP0009053_abnormal_anal_canal2.04700120
22MP0003806_abnormal_nucleotide_metabolis2.03548186
23MP0009780_abnormal_chondrocyte_physiolo2.02303205
24MP0004782_abnormal_surfactant_physiolog2.01148585
25MP0008004_abnormal_stomach_pH1.98281340
26MP0003950_abnormal_plasma_membrane1.90813273
27MP0004043_abnormal_pH_regulation1.90285802
28MP0010678_abnormal_skin_adnexa1.78275321
29MP0003183_abnormal_peptide_metabolism1.76615104
30MP0003191_abnormal_cellular_cholesterol1.73165016
31MP0001849_ear_inflammation1.70546875
32MP0000516_abnormal_urinary_system1.70230845
33MP0005367_renal/urinary_system_phenotyp1.70230845
34MP0010030_abnormal_orbit_morphology1.67031499
35MP0003866_abnormal_defecation1.66503214
36MP0002098_abnormal_vibrissa_morphology1.61982302
37MP0010352_gastrointestinal_tract_polyps1.56604265
38MP0003091_abnormal_cell_migration1.55156228
39MP0003453_abnormal_keratinocyte_physiol1.53503312
40MP0009643_abnormal_urine_homeostasis1.53126925
41MP0003195_calcinosis1.50793560
42MP0000377_abnormal_hair_follicle1.49023473
43MP0003119_abnormal_digestive_system1.45231920
44MP0001664_abnormal_digestion1.43060096
45MP0000538_abnormal_urinary_bladder1.39034845
46MP0003315_abnormal_perineum_morphology1.38250458
47MP0000566_synostosis1.36331902
48MP0001765_abnormal_ion_homeostasis1.35398406
49MP0001756_abnormal_urination1.31643915
50MP0000613_abnormal_salivary_gland1.31612939
51MP0002796_impaired_skin_barrier1.31596384
52MP0005451_abnormal_body_composition1.30398331
53MP0004185_abnormal_adipocyte_glucose1.28788113
54MP0002896_abnormal_bone_mineralization1.26727189
55MP0000003_abnormal_adipose_tissue1.23269858
56MP0005409_darkened_coat_color1.20984004
57MP0001666_abnormal_nutrient_absorption1.19706925
58MP0003045_fibrosis1.19366202
59MP0003115_abnormal_respiratory_system1.19056514
60MP0004233_abnormal_muscle_weight1.18715814
61MP0005083_abnormal_biliary_tract1.18461314
62MP0005167_abnormal_blood-brain_barrier1.13758980
63MP0002060_abnormal_skin_morphology1.13523067
64MP0001216_abnormal_epidermal_layer1.10083116
65MP0005248_abnormal_Harderian_gland1.10017201
66MP0002254_reproductive_system_inflammat1.09780280
67MP0005275_abnormal_skin_tensile1.09059407
68MP0001879_abnormal_lymphatic_vessel1.08557254
69MP0000470_abnormal_stomach_morphology1.08105874
70MP0008260_abnormal_autophagy1.06629751
71MP0010368_abnormal_lymphatic_system1.06364851
72MP0004957_abnormal_blastocyst_morpholog1.05962701
73MP0001958_emphysema1.05616841
74MP0001348_abnormal_lacrimal_gland1.05375426
75MP0009931_abnormal_skin_appearance1.03519798
76MP0002277_abnormal_respiratory_mucosa1.03444222
77MP0002928_abnormal_bile_duct1.03268196
78MP0000477_abnormal_intestine_morphology0.99494327
79MP0005023_abnormal_wound_healing0.98247599
80MP0008875_abnormal_xenobiotic_pharmacok0.97582776
81MP0008438_abnormal_cutaneous_collagen0.96451454
82MP0001661_extended_life_span0.96347936
83MP0005501_abnormal_skin_physiology0.94709140
84MP0008932_abnormal_embryonic_tissue0.93339585
85MP0010155_abnormal_intestine_physiology0.93261414
86MP0001243_abnormal_dermal_layer0.93195778
87MP0000627_abnormal_mammary_gland0.93028540
88MP0005076_abnormal_cell_differentiation0.92170699
89MP0000681_abnormal_thyroid_gland0.91433749
90MP0000733_abnormal_muscle_development0.91019900
91MP0000383_abnormal_hair_follicle0.89599582
92MP0005330_cardiomyopathy0.88755909
93MP0000534_abnormal_ureter_morphology0.88740604
94MP0005375_adipose_tissue_phenotype0.88391323
95MP0006072_abnormal_retinal_apoptosis0.87986273
96MP0000467_abnormal_esophagus_morphology0.87407243
97MP0005408_hypopigmentation0.87169604
98MP0000858_altered_metastatic_potential0.86265711
99MP0001340_abnormal_eyelid_morphology0.85680833
100MP0005084_abnormal_gallbladder_morpholo0.84825142
101MP0005636_abnormal_mineral_homeostasis0.83534635
102MP0006138_congestive_heart_failure0.82371444
103MP0000762_abnormal_tongue_morphology0.81749669
104MP0004019_abnormal_vitamin_homeostasis0.81412615
105MP0005621_abnormal_cell_physiology0.81244846
106MP0002136_abnormal_kidney_physiology0.81113526
107MP0000647_abnormal_sebaceous_gland0.80573954
108MP0005381_digestive/alimentary_phenotyp0.80323843
109MP0001730_embryonic_growth_arrest0.80304290
110MP0003786_premature_aging0.79874860
111MP0002295_abnormal_pulmonary_circulatio0.79511019
112MP0001346_abnormal_lacrimal_gland0.78963961
113MP0001191_abnormal_skin_condition0.78106947
114MP0005379_endocrine/exocrine_gland_phen0.77866313
115MP0005197_abnormal_uvea_morphology0.77387351
116MP0004947_skin_inflammation0.76532256
117MP0003693_abnormal_embryo_hatching0.76048487
118MP0005165_increased_susceptibility_to0.75679699
119MP0004858_abnormal_nervous_system0.75014915
120MP0003941_abnormal_skin_development0.74908143
121MP0002086_abnormal_extraembryonic_tissu0.74410905
122MP0003890_abnormal_embryonic-extraembry0.74388453
123MP0000367_abnormal_coat/_hair0.74357810
124MP0002168_other_aberrant_phenotype0.74135015
125MP0003705_abnormal_hypodermis_morpholog0.74114063
126MP0002078_abnormal_glucose_homeostasis0.73831071
127MP0003755_abnormal_palate_morphology0.73196885
128MP0005257_abnormal_intraocular_pressure0.71965247
129MP0005058_abnormal_lysosome_morphology0.71087183
130MP0000750_abnormal_muscle_regeneration0.70322268
131MP0005666_abnormal_adipose_tissue0.69851042
132MP0000350_abnormal_cell_proliferation0.69053662
133MP0002697_abnormal_eye_size0.67651169
134MP0001270_distended_abdomen0.66962366
135MP0005193_abnormal_anterior_eye0.66540450
136MP0005310_abnormal_salivary_gland0.66235034
137MP0001873_stomach_inflammation0.66154064
138MP0002080_prenatal_lethality0.65950659
139MP0009840_abnormal_foam_cell0.64985211
140MP0008007_abnormal_cellular_replicative0.63824150
141MP0010771_integument_phenotype0.63822129
142MP0001881_abnormal_mammary_gland0.63806213
143MP0000427_abnormal_hair_cycle0.63722912
144MP0002177_abnormal_outer_ear0.62959191
145MP0000163_abnormal_cartilage_morphology0.62682018
146MP0005360_urolithiasis0.62287342
147MP0000490_abnormal_crypts_of0.59949010
148MP0000358_abnormal_cell_content/0.59532882
149MP0008961_abnormal_basal_metabolism0.56978761
150MP0002837_dystrophic_cardiac_calcinosis0.55454330
151MP0000579_abnormal_nail_morphology0.55393949
152MP0003252_abnormal_bile_duct0.54277865

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)6.15138911
2Interstitial pulmonary disease (HP:0006530)5.20170068
3Hyperactive renin-angiotensin system (HP:0000841)5.08002983
4Right ventricular cardiomyopathy (HP:0011663)4.67071002
5Milia (HP:0001056)4.40589583
6Atrophic scars (HP:0001075)4.35085787
7Micronodular cirrhosis (HP:0001413)4.32151413
8Hypoglycemic seizures (HP:0002173)4.17870851
9Hyperinsulinemic hypoglycemia (HP:0000825)4.11470032
10Fragile nails (HP:0001808)4.08964367
11Selective tooth agenesis (HP:0001592)3.99026396
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.88943979
13Short nail (HP:0001799)3.86515998
14Symptomatic seizures (HP:0011145)3.85073841
15Abnormal pancreas size (HP:0012094)3.81627426
16Abnormality of chloride homeostasis (HP:0011422)3.81237469
17Thick nail (HP:0001805)3.56615786
18Gout (HP:0001997)3.52348848
19Alopecia of scalp (HP:0002293)3.49912533
20Hypoglycemic coma (HP:0001325)3.44084862
21Renal salt wasting (HP:0000127)3.41346605
22Trismus (HP:0000211)3.38467061
23Unilateral renal agenesis (HP:0000122)3.33955752
24Abnormality of the gastric mucosa (HP:0004295)3.29746146
25Abnormality of nail color (HP:0100643)3.27986381
26Ridged nail (HP:0001807)3.26650242
27Pili torti (HP:0003777)3.26420076
28Abdominal distention (HP:0003270)3.21635672
29Distal lower limb amyotrophy (HP:0008944)3.21338746
30Pterygium (HP:0001059)3.18281198
31Chronic bronchitis (HP:0004469)3.09750826
32Hyperparathyroidism (HP:0000843)3.08017545
33Hypotrichosis (HP:0001006)3.07198902
34Premature rupture of membranes (HP:0001788)3.06313114
35Hypoplasia of dental enamel (HP:0006297)3.06029953
36Decreased circulating renin level (HP:0003351)3.03682405
37Natal tooth (HP:0000695)3.01708965
38Abnormality of renin-angiotensin system (HP:0000847)3.01373890
39Focal segmental glomerulosclerosis (HP:0000097)2.98848567
40Palmoplantar hyperkeratosis (HP:0000972)2.96258003
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.92218687
42Osteolytic defects of the hand bones (HP:0009699)2.92218687
43Glomerulosclerosis (HP:0000096)2.91426005
44Hyperacusis (HP:0010780)2.91380320
45Curly hair (HP:0002212)2.87753425
46Late onset (HP:0003584)2.86709830
47Plantar hyperkeratosis (HP:0007556)2.85574875
48Hyperglycemia (HP:0003074)2.79111179
49Distal lower limb muscle weakness (HP:0009053)2.78201582
50Hyperkalemia (HP:0002153)2.77979900
51Ankyloglossia (HP:0010296)2.77852241
52Sparse eyelashes (HP:0000653)2.77256624
53Palmar hyperkeratosis (HP:0010765)2.72977766
54Hyperphosphatemia (HP:0002905)2.71350316
55Abnormality of oral frenula (HP:0000190)2.65982650
56Urinary glycosaminoglycan excretion (HP:0003541)2.65078599
57Mucopolysacchariduria (HP:0008155)2.65078599
58Hyperaldosteronism (HP:0000859)2.64387524
59Vascular calcification (HP:0004934)2.63010750
60Esophageal varix (HP:0002040)2.62286358
61Abnormality of endocrine pancreas physiology (HP:0012093)2.59521409
62Abnormality of the pancreatic islet cells (HP:0006476)2.59521409
63Abnormality of calcium-phosphate metabolism (HP:0100530)2.56201561
64Insulin-resistant diabetes mellitus (HP:0000831)2.55072680
65Reduced subcutaneous adipose tissue (HP:0003758)2.54215696
66Adrenal overactivity (HP:0002717)2.54082738
67Hypokalemia (HP:0002900)2.46700638
68Advanced eruption of teeth (HP:0006288)2.45444974
69Popliteal pterygium (HP:0009756)2.45107110
70Aplasia/hypoplasia of the uterus (HP:0008684)2.44890996
71Hypercortisolism (HP:0001578)2.43777951
72Hypokalemic alkalosis (HP:0001949)2.42698875
73Dysostosis multiplex (HP:0000943)2.42583977
74Tetany (HP:0001281)2.39548732
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38579057
76Abnormality of polysaccharide metabolism (HP:0011012)2.38579057
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38579057
78Cardiovascular calcification (HP:0011915)2.37964419
79Pustule (HP:0200039)2.37588481
80Hypotension (HP:0002615)2.36155699
81Increased connective tissue (HP:0009025)2.30736030
82Nail dystrophy (HP:0008404)2.26949166
83Abnormal biliary tract morphology (HP:0012440)2.26935349
84Large for gestational age (HP:0001520)2.25973796
85Abnormality of the distal phalanges of the toes (HP:0010182)2.25511212
86Exocrine pancreatic insufficiency (HP:0001738)2.24572561
87Abnormality of small intestinal villus morphology (HP:0011472)2.24245048
88Villous atrophy (HP:0011473)2.24245048
89Biliary tract neoplasm (HP:0100574)2.23167778
90Abnormality of potassium homeostasis (HP:0011042)2.22584628
91Acanthosis nigricans (HP:0000956)2.22474905
92Aplasia cutis congenita (HP:0001057)2.22063067
93Bronchomalacia (HP:0002780)2.21693727
94Insulin resistance (HP:0000855)2.21308788
95Progressive sensorineural hearing impairment (HP:0000408)2.19333154
96Flat acetabular roof (HP:0003180)2.19043041
97Cervical subluxation (HP:0003308)2.18952792
98Hypokinesia (HP:0002375)2.18510101
99Woolly hair (HP:0002224)2.17526729
100Vertebral compression fractures (HP:0002953)2.16071435
101Ketoacidosis (HP:0001993)2.16002801
102Lip pit (HP:0100267)2.13746002
103Achilles tendon contracture (HP:0001771)2.12150644
104Tubulointerstitial fibrosis (HP:0005576)2.11793964
105Deviation of the thumb (HP:0009603)2.11272207
106Rectal prolapse (HP:0002035)2.10991552
107Subacute progressive viral hepatitis (HP:0006572)2.10076816
108Lower limb amyotrophy (HP:0007210)2.09494594
109Growth hormone excess (HP:0000845)2.06333107
110Abnormal blistering of the skin (HP:0008066)2.04726155
111Congenital sensorineural hearing impairment (HP:0008527)2.04520104
112Difficulty climbing stairs (HP:0003551)2.01853218
113Arterial tortuosity (HP:0005116)2.01419731
114Germ cell neoplasia (HP:0100728)2.01016122
115Hypoplasia of the uterus (HP:0000013)1.99708842
11611 pairs of ribs (HP:0000878)1.99356138
117Distal upper limb amyotrophy (HP:0007149)1.99142089
118Upper limb amyotrophy (HP:0009129)1.99142089
119Pancreatic islet-cell hyperplasia (HP:0004510)1.96591437
120Ulnar bowing (HP:0003031)1.94424396
121Dehydration (HP:0001944)1.93976706
122Ventricular tachycardia (HP:0004756)1.92264736
123Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92207206
124Vertebral hypoplasia (HP:0008417)1.92207206
125Glucose intolerance (HP:0000833)1.89936847
126Entropion (HP:0000621)1.89765540
127Abnormality of renal excretion (HP:0011036)1.88968959
128Poikiloderma (HP:0001029)1.87684087
129Fragile skin (HP:0001030)1.87198712
130Abnormality of the Achilles tendon (HP:0005109)1.86078578
131Uterine neoplasm (HP:0010784)1.86024978
132Broad face (HP:0000283)1.85976742
133Protrusio acetabuli (HP:0003179)1.85697180
134Intestinal atresia (HP:0011100)1.85125293
135Rough bone trabeculation (HP:0100670)1.84622130
136Taurodontia (HP:0000679)1.84447625
137Abnormality of permanent molar morphology (HP:0011071)1.84447625
138Abnormality of the dental root (HP:0006486)1.84447625
139Thin bony cortex (HP:0002753)1.83887246
140Cheilitis (HP:0100825)1.82832509
141Congenital glaucoma (HP:0001087)1.82555271
142Spinal cord compression (HP:0002176)1.81349702
143Hypoplastic labia majora (HP:0000059)1.80466241
144Vascular tortuosity (HP:0004948)1.80161863
145Hyperuricemia (HP:0002149)1.80067271
146Increased purine levels (HP:0004368)1.80067271
147Breast carcinoma (HP:0003002)1.79239480
148Abnormal hair laboratory examination (HP:0003328)1.79205330
149Abnormality of the salivary glands (HP:0010286)1.77274613
150Brittle hair (HP:0002299)1.76997938
151Amelogenesis imperfecta (HP:0000705)1.74636550
152Abnormal hemoglobin (HP:0011902)1.74424560
153Vacuolated lymphocytes (HP:0001922)1.73082156
154Breast hypoplasia (HP:0003187)1.72832424
155Anonychia (HP:0001798)1.70307508
156Abnormality of molar (HP:0011077)1.69691592
157Abnormality of molar morphology (HP:0011070)1.69691592
158Sparse scalp hair (HP:0002209)1.68220693
159Erythema (HP:0010783)1.67584695
160Bowed forearm bones (HP:0003956)1.67169723
161Bowing of the arm (HP:0006488)1.67169723
162Elbow flexion contracture (HP:0002987)1.65409356
163Neonatal death (HP:0003811)1.65149718
164Abnormalities of placenta or umbilical cord (HP:0001194)1.64657491
165Hoarse voice (HP:0001609)1.64398234
166Dry hair (HP:0011359)1.62901900
167Amniotic constriction ring (HP:0009775)1.61592590
168Abnormality of placental membranes (HP:0011409)1.61592590
169Hydroureter (HP:0000072)1.60042785
170Aplasia/Hypoplasia of the clavicles (HP:0006710)1.59770116
171Long palpebral fissure (HP:0000637)1.58933056
172Proximal placement of thumb (HP:0009623)1.57882175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA29.07942229
2MST43.37951092
3MAPK153.31612001
4FRK2.70468370
5NME22.67721297
6INSRR2.66243456
7PASK2.66028655
8FER2.48190594
9PTK22.46007269
10MAP3K22.37792463
11MAP2K22.30841450
12PTK62.07824376
13TRIB31.89575013
14PAK41.87273371
15ARAF1.86993728
16MAP3K91.85788501
17WNK41.81109523
18MST1R1.76799970
19EPHB21.75770015
20SMG11.68249788
21MET1.66543246
22RPS6KB21.60817936
23EPHB11.50567105
24LATS21.49537738
25ERN11.49228304
26TESK11.49055411
27BUB11.44577015
28NME11.43711348
29LATS11.36944727
30TAOK31.35653121
31WNK31.35355602
32MAP3K31.34699531
33PRKG21.31865175
34PBK1.31252042
35HIPK21.29699414
36DYRK1B1.26112528
37RIPK11.24956037
38ERBB31.23675829
39LRRK21.21645614
40FLT31.18268306
41EPHA31.15445433
42PDGFRA1.12116538
43CDK121.11768504
44EIF2AK11.11643106
45PRKCI1.07914346
46CDK81.04031415
47PKN21.03934911
48MAP2K11.00466643
49NEK11.00145437
50MAP3K10.99018181
51LMTK20.91111581
52TGFBR20.85383124
53FGFR40.85380405
54SCYL20.79883258
55STK38L0.78700149
56CHUK0.78657701
57TRPM70.77357046
58NTRK10.77105068
59STK100.76687631
60NUAK10.76624615
61PAK30.76398476
62TESK20.75769912
63BMX0.74907863
64BCR0.73275001
65ICK0.73245570
66ABL20.73105455
67IRAK30.71314134
68STK380.71146998
69TIE10.68475069
70MYLK0.66024674
71CDC42BPA0.63726003
72ZAP700.63396847
73CAMK2B0.62974294
74MAP3K130.62257533
75CSK0.57513791
76GSK3A0.57273178
77BRAF0.56327453
78CAMK2D0.56066791
79STK240.55821992
80NEK90.55607316
81BRSK10.55433743
82SIK30.54884629
83MAP3K60.54752951
84PDGFRB0.53517513
85PRKCE0.52444682
86TTN0.52352300
87AURKA0.51118964
88MAP3K120.50954338
89LIMK10.50038806
90TGFBR10.49572094
91VRK20.49256341
92MELK0.48781820
93DDR20.48774350
94ERBB20.47815296
95RPS6KA40.46198870
96ERBB40.44314376
97KSR10.43367290
98PRKD30.43116222
99CDK90.42576337
100CDK70.42032503
101ILK0.41148085
102PIK3CG0.41014609
103MOS0.40522979
104PIM20.39537257
105NLK0.38157669
106STK30.37400576
107CAMK2G0.36026836
108DAPK10.35863400
109MAPKAPK30.34657641
110MAP2K60.33618015
111KSR20.33059571
112EGFR0.32382932
113PRKD20.32333025
114SIK10.32064773
115TBK10.31192793
116CDK60.29916903
117MAP3K80.29812069
118PAK10.29502470
119MAPKAPK20.29031040
120IRAK20.28508903
121ROCK20.28217173
122TTK0.26973705
123RPS6KA20.26642643
124JAK30.26555671
125SRC0.26465731
126PRKD10.26074929
127DMPK0.26007347
128PTK2B0.25846703
129MTOR0.24476956
130RAF10.24420954
131MATK0.24001903
132EIF2AK30.23810867
133GRK10.22791520
134DYRK30.22657201
135BRSK20.22540443
136AKT20.20972990
137PAK20.20548890
138ROCK10.19695660
139IGF1R0.18828482
140PHKG20.18559267
141PHKG10.18559267
142AURKB0.16774972
143FGFR10.15343346

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.13602205
2Protein export_Homo sapiens_hsa030603.54152450
3Sulfur metabolism_Homo sapiens_hsa009203.37938733
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.71282861
5Bladder cancer_Homo sapiens_hsa052192.41395730
6Pentose phosphate pathway_Homo sapiens_hsa000302.33724150
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.23242473
8Vibrio cholerae infection_Homo sapiens_hsa051102.22413001
9ECM-receptor interaction_Homo sapiens_hsa045122.09045854
10Fructose and mannose metabolism_Homo sapiens_hsa000512.08951868
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06388227
12Proteasome_Homo sapiens_hsa030502.05324926
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.94115906
14Adherens junction_Homo sapiens_hsa045201.90959191
15Tight junction_Homo sapiens_hsa045301.90784175
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.89513829
17Thyroid cancer_Homo sapiens_hsa052161.78110620
18Other glycan degradation_Homo sapiens_hsa005111.67474246
19Small cell lung cancer_Homo sapiens_hsa052221.66276963
20N-Glycan biosynthesis_Homo sapiens_hsa005101.65352704
21Biosynthesis of amino acids_Homo sapiens_hsa012301.57971753
22Lysosome_Homo sapiens_hsa041421.51872398
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.51172125
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50822635
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49892025
26Insulin secretion_Homo sapiens_hsa049111.44043249
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37633632
28Focal adhesion_Homo sapiens_hsa045101.34969253
29Mineral absorption_Homo sapiens_hsa049781.34365804
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33556245
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.30933726
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.25382701
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23004321
34Hippo signaling pathway_Homo sapiens_hsa043901.22481043
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21362545
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21062632
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20884505
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20867501
39Tyrosine metabolism_Homo sapiens_hsa003501.20351087
40Vitamin B6 metabolism_Homo sapiens_hsa007501.15859063
41Thyroid hormone synthesis_Homo sapiens_hsa049181.13202508
42Proteoglycans in cancer_Homo sapiens_hsa052051.08318070
43Carbon metabolism_Homo sapiens_hsa012001.06390735
44Sphingolipid metabolism_Homo sapiens_hsa006001.04451703
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04280812
46Selenocompound metabolism_Homo sapiens_hsa004501.03475553
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03232877
48Sulfur relay system_Homo sapiens_hsa041221.00383390
49Amoebiasis_Homo sapiens_hsa051461.00120243
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99946954
51Notch signaling pathway_Homo sapiens_hsa043300.99425447
52Pancreatic secretion_Homo sapiens_hsa049720.96858379
53Endometrial cancer_Homo sapiens_hsa052130.96516925
54DNA replication_Homo sapiens_hsa030300.96071262
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95957576
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95226217
57Toxoplasmosis_Homo sapiens_hsa051450.93882962
58Pyrimidine metabolism_Homo sapiens_hsa002400.93600960
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86106131
60ErbB signaling pathway_Homo sapiens_hsa040120.85952817
61Chronic myeloid leukemia_Homo sapiens_hsa052200.85520163
62Histidine metabolism_Homo sapiens_hsa003400.85326073
63Prolactin signaling pathway_Homo sapiens_hsa049170.84919741
64Starch and sucrose metabolism_Homo sapiens_hsa005000.83607281
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.82252215
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81929025
67Hepatitis C_Homo sapiens_hsa051600.81357404
68Axon guidance_Homo sapiens_hsa043600.78137089
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77873758
70Hematopoietic cell lineage_Homo sapiens_hsa046400.76672786
71Pancreatic cancer_Homo sapiens_hsa052120.76337490
72Type I diabetes mellitus_Homo sapiens_hsa049400.75968602
73Glutathione metabolism_Homo sapiens_hsa004800.75749488
74Cell cycle_Homo sapiens_hsa041100.74118727
75Folate biosynthesis_Homo sapiens_hsa007900.73878751
76Antigen processing and presentation_Homo sapiens_hsa046120.73056070
77Protein digestion and absorption_Homo sapiens_hsa049740.72270284
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70331176
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70058883
80Shigellosis_Homo sapiens_hsa051310.69729930
81Type II diabetes mellitus_Homo sapiens_hsa049300.69705991
82TNF signaling pathway_Homo sapiens_hsa046680.68611684
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.65484432
84Mismatch repair_Homo sapiens_hsa034300.64838437
85Nucleotide excision repair_Homo sapiens_hsa034200.64388101
86Legionellosis_Homo sapiens_hsa051340.63408125
87Renal cell carcinoma_Homo sapiens_hsa052110.62883356
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62166263
89Linoleic acid metabolism_Homo sapiens_hsa005910.61742416
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61178408
91Base excision repair_Homo sapiens_hsa034100.60651939
92Prostate cancer_Homo sapiens_hsa052150.60368736
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60335432
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59798799
95Pyruvate metabolism_Homo sapiens_hsa006200.59445177
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59281315
97Galactose metabolism_Homo sapiens_hsa000520.59172172
98Arachidonic acid metabolism_Homo sapiens_hsa005900.59086086
99Pertussis_Homo sapiens_hsa051330.59016872
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58509722
101Fat digestion and absorption_Homo sapiens_hsa049750.56694911
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56614239
103Salmonella infection_Homo sapiens_hsa051320.56331569
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56329813
105Non-small cell lung cancer_Homo sapiens_hsa052230.54432419
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54289730
107Pathways in cancer_Homo sapiens_hsa052000.53696132
108Insulin signaling pathway_Homo sapiens_hsa049100.51117804
109Arginine biosynthesis_Homo sapiens_hsa002200.50675168
110Chemical carcinogenesis_Homo sapiens_hsa052040.49633315
111Viral carcinogenesis_Homo sapiens_hsa052030.49106728
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48828711
113Glioma_Homo sapiens_hsa052140.47637971
114TGF-beta signaling pathway_Homo sapiens_hsa043500.47174450
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46780869
116Taste transduction_Homo sapiens_hsa047420.46761152
117Estrogen signaling pathway_Homo sapiens_hsa049150.46673791
118Circadian rhythm_Homo sapiens_hsa047100.46557770
119Prion diseases_Homo sapiens_hsa050200.45540525
120Fatty acid elongation_Homo sapiens_hsa000620.44794757
121Phagosome_Homo sapiens_hsa041450.44688726
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44311132
123Cocaine addiction_Homo sapiens_hsa050300.43383210
124Apoptosis_Homo sapiens_hsa042100.42882091
125Steroid biosynthesis_Homo sapiens_hsa001000.41859299
126Insulin resistance_Homo sapiens_hsa049310.41745127
127Melanoma_Homo sapiens_hsa052180.41410506
128Endocytosis_Homo sapiens_hsa041440.41130498
129MicroRNAs in cancer_Homo sapiens_hsa052060.40904357
130p53 signaling pathway_Homo sapiens_hsa041150.39558052
131Rap1 signaling pathway_Homo sapiens_hsa040150.38718833
132beta-Alanine metabolism_Homo sapiens_hsa004100.38674329
133Basal cell carcinoma_Homo sapiens_hsa052170.38222418
134Hedgehog signaling pathway_Homo sapiens_hsa043400.37800850
135Rheumatoid arthritis_Homo sapiens_hsa053230.36452983
136Dilated cardiomyopathy_Homo sapiens_hsa054140.35252169
137Ether lipid metabolism_Homo sapiens_hsa005650.34392829
138Phenylalanine metabolism_Homo sapiens_hsa003600.33676725
139Wnt signaling pathway_Homo sapiens_hsa043100.31711772
140Renin-angiotensin system_Homo sapiens_hsa046140.31180254
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31170203
142Acute myeloid leukemia_Homo sapiens_hsa052210.29788866
143Gastric acid secretion_Homo sapiens_hsa049710.29301175
144Tryptophan metabolism_Homo sapiens_hsa003800.29236991
145Melanogenesis_Homo sapiens_hsa049160.29071761
146VEGF signaling pathway_Homo sapiens_hsa043700.28826952

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