KRT72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.85540071
2citrulline biosynthetic process (GO:0019240)9.41894021
3adhesion of symbiont to host (GO:0044406)8.90658654
4hair follicle morphogenesis (GO:0031069)8.63382651
5peptide cross-linking (GO:0018149)8.22232409
6positive regulation of gamma-delta T cell activation (GO:0046645)7.28306832
7intermediate filament cytoskeleton organization (GO:0045104)6.81824583
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.77211881
9negative regulation of cell killing (GO:0031342)6.76976234
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.76976234
11intermediate filament-based process (GO:0045103)6.60475684
12citrulline metabolic process (GO:0000052)6.23977782
13response to interleukin-15 (GO:0070672)5.96475512
14epidermis development (GO:0008544)5.96462797
15negative regulation of erythrocyte differentiation (GO:0045647)5.88270568
16regulation of gamma-delta T cell differentiation (GO:0045586)5.87507084
17negative thymic T cell selection (GO:0045060)5.80880018
18cell wall macromolecule catabolic process (GO:0016998)5.77812114
19cell wall macromolecule metabolic process (GO:0044036)5.77812114
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.72024204
21negative T cell selection (GO:0043383)5.70746501
22regulation of gamma-delta T cell activation (GO:0046643)5.60132243
23cellular response to interleukin-15 (GO:0071350)5.60056854
24hair cycle process (GO:0022405)5.52981286
25molting cycle process (GO:0022404)5.52981286
26keratinocyte differentiation (GO:0030216)5.47822476
27leukocyte aggregation (GO:0070486)5.31854608
28peptidyl-arginine modification (GO:0018195)5.26677458
29antigen processing and presentation of endogenous antigen (GO:0019883)5.23594281
30bundle of His cell to Purkinje myocyte communication (GO:0086069)5.08310793
31regulation of B cell receptor signaling pathway (GO:0050855)5.00743722
32activated T cell proliferation (GO:0050798)4.96738618
33thymic T cell selection (GO:0045061)4.75011650
34positive thymic T cell selection (GO:0045059)4.72933236
35positive T cell selection (GO:0043368)4.66210710
36hemidesmosome assembly (GO:0031581)4.63857029
37T cell selection (GO:0045058)4.61970795
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.56184491
39positive regulation of granulocyte differentiation (GO:0030854)4.50499359
40skin morphogenesis (GO:0043589)4.45524513
41establishment of skin barrier (GO:0061436)4.38889106
42epidermal cell differentiation (GO:0009913)4.29734566
43cellular extravasation (GO:0045123)4.27224872
44T cell migration (GO:0072678)4.19735083
45regulation of T cell tolerance induction (GO:0002664)4.12318276
46negative regulation of T cell mediated immunity (GO:0002710)4.11566785
47negative regulation of lymphocyte mediated immunity (GO:0002707)4.10740549
48molting cycle (GO:0042303)35.9713619
49hair cycle (GO:0042633)35.9713619
50regulation of water loss via skin (GO:0033561)3.94208201
51tolerance induction (GO:0002507)3.92238392
52detection of bacterium (GO:0016045)3.85508700
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83865452
54positive regulation by organism of defense response of other organism involved in symbiotic interact3.83865452
55modulation by symbiont of host immune response (GO:0052553)3.83865452
56positive regulation by symbiont of host defense response (GO:0052509)3.83865452
57modulation by symbiont of host defense response (GO:0052031)3.83865452
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83865452
59detection of other organism (GO:0098543)3.78005935
60keratinocyte development (GO:0003334)3.70198575
61tooth mineralization (GO:0034505)3.69529705
62negative regulation of phagocytosis (GO:0050765)3.69470804
63regulation of tolerance induction (GO:0002643)3.66494828
64negative regulation of leukocyte mediated immunity (GO:0002704)3.63722820
65regulation of granulocyte differentiation (GO:0030852)3.61522683
66regulation of alpha-beta T cell proliferation (GO:0046640)3.57315077
67B cell receptor signaling pathway (GO:0050853)3.55053571
68positive regulation of tolerance induction (GO:0002645)3.54725581
69regulation of B cell differentiation (GO:0045577)3.51837803
70positive regulation of B cell differentiation (GO:0045579)3.43535969
71T cell homeostasis (GO:0043029)3.43288850
72neutrophil activation involved in immune response (GO:0002283)3.40422520
73positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40202575
74negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.39899803
75mast cell activation (GO:0045576)3.36977543
76phosphatidylinositol acyl-chain remodeling (GO:0036149)3.35943913
77negative regulation of keratinocyte proliferation (GO:0010839)3.35893858
78regulation of natural killer cell mediated immunity (GO:0002715)3.31138973
79regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.31138973
80signal complex assembly (GO:0007172)3.30102051
81T cell receptor signaling pathway (GO:0050852)3.29294238
82natural killer cell differentiation (GO:0001779)3.25226776
83hair follicle development (GO:0001942)3.24499321
84histone H3-K36 demethylation (GO:0070544)3.22203419
85antigen receptor-mediated signaling pathway (GO:0050851)3.21982784
86regulation of interleukin-2 biosynthetic process (GO:0045076)3.21727568
87positive regulation of hair cycle (GO:0042635)3.20784428
88positive regulation of hair follicle development (GO:0051798)3.20784428
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19148342
90macrophage activation involved in immune response (GO:0002281)3.18765685
91regulation of regulatory T cell differentiation (GO:0045589)3.18019214
92regulation of keratinocyte differentiation (GO:0045616)3.16145201
93regulation of T cell mediated cytotoxicity (GO:0001914)3.13181593
94negative regulation of interleukin-12 production (GO:0032695)3.09603338
95response to muramyl dipeptide (GO:0032495)3.08881178
96leukocyte degranulation (GO:0043299)3.08184250
97respiratory burst (GO:0045730)3.07117723
98phosphatidylserine acyl-chain remodeling (GO:0036150)3.05862325
99mucosal-associated lymphoid tissue development (GO:0048537)3.04701966
100Peyers patch development (GO:0048541)3.04701966
101positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03087052
102regulation of hair follicle development (GO:0051797)3.02728426
103alpha-beta T cell differentiation (GO:0046632)3.01444396
104regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00072268
105interferon-gamma production (GO:0032609)2.99888886
106positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99092952
107myeloid cell activation involved in immune response (GO:0002275)2.96704639
108lymphocyte homeostasis (GO:0002260)2.92900089
109positive regulation of interleukin-4 production (GO:0032753)2.90034589
110mast cell activation involved in immune response (GO:0002279)2.88851145
111mast cell degranulation (GO:0043303)2.88851145
112positive regulation of histone deacetylation (GO:0031065)2.87833605
113positive regulation of interleukin-2 production (GO:0032743)2.85101255
114phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.85016783
115negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84881431
116alpha-beta T cell activation (GO:0046631)2.84622671
117type I interferon signaling pathway (GO:0060337)2.82683987
118cellular response to type I interferon (GO:0071357)2.82683987
119neutrophil activation (GO:0042119)2.82661113
120response to type I interferon (GO:0034340)2.82427751
121regulation of interferon-beta biosynthetic process (GO:0045357)2.82419378
122epithelium development (GO:0060429)2.82389893
123regulation of histone H3-K27 methylation (GO:0061085)2.81806139
124regulation of leukocyte mediated cytotoxicity (GO:0001910)2.80229064
125regulation of interleukin-4 production (GO:0032673)2.79836951
126negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79415181
127regulation of alpha-beta T cell activation (GO:0046634)2.79330860
128negative regulation of protein localization to plasma membrane (GO:1903077)2.79052430
129negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77862627
130negative regulation of T-helper cell differentiation (GO:0045623)2.77862627
131antigen processing and presentation via MHC class Ib (GO:0002475)2.76788237
132positive regulation of natural killer cell differentiation (GO:0032825)2.74191024
133detection of external biotic stimulus (GO:0098581)2.73579785
134gap junction assembly (GO:0016264)2.73313468
135bone trabecula formation (GO:0060346)2.72987054
136positive regulation of isotype switching (GO:0045830)2.72794442
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71011892
138multicellular organismal water homeostasis (GO:0050891)2.67990076
139positive regulation of epidermis development (GO:0045684)2.67925577
140regulation of hair cycle (GO:0042634)2.66718396
141positive regulation of meiotic cell cycle (GO:0051446)2.66071574
142ectoderm development (GO:0007398)2.62716460
143atrioventricular valve morphogenesis (GO:0003181)2.55618347
144regulation of epidermal cell differentiation (GO:0045604)2.47219315
145epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.41323515
146regulation of epidermis development (GO:0045682)2.40828496
147ventricular cardiac muscle cell action potential (GO:0086005)2.39598562
148phosphatidylserine metabolic process (GO:0006658)2.31449815
149phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.24679486
150water homeostasis (GO:0030104)2.19836779
151negative regulation of cell fate specification (GO:0009996)2.18337047
152positive regulation of epidermal cell differentiation (GO:0045606)2.17772041
153regulation of mesenchymal cell apoptotic process (GO:2001053)2.15768400
154fatty acid elongation (GO:0030497)2.15403042
155cell surface receptor signaling pathway involved in heart development (GO:0061311)2.14051353
156wound healing, spreading of epidermal cells (GO:0035313)2.12438489
157aging (GO:0007568)2.11702790
158cranial suture morphogenesis (GO:0060363)2.07367660
159lymph vessel development (GO:0001945)2.04026755
160regulation of heart rate by cardiac conduction (GO:0086091)2.03485935
161regulation of cardioblast differentiation (GO:0051890)2.00042230
162intermediate filament organization (GO:0045109)12.5004621
163virion attachment to host cell (GO:0019062)10.5291905
164adhesion of symbiont to host cell (GO:0044650)10.5291905
165keratinization (GO:0031424)10.1442501
166phosphatidylcholine acyl-chain remodeling (GO:0036151)1.98586603
167positive regulation of monocyte chemotaxis (GO:0090026)1.95085611
168negative regulation of epidermis development (GO:0045683)1.93785973
169skin development (GO:0043588)1.93489918
170cytoskeletal anchoring at plasma membrane (GO:0007016)1.92205835
171outflow tract septum morphogenesis (GO:0003148)1.91897836
172epithelial cell-cell adhesion (GO:0090136)1.90700925
173regulation of keratinocyte proliferation (GO:0010837)1.88475138
174cell communication involved in cardiac conduction (GO:0086065)1.87927181
175planar cell polarity pathway involved in neural tube closure (GO:0090179)1.85676504
176regulation of ruffle assembly (GO:1900027)1.84606845
177regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.82591733
178myotube differentiation (GO:0014902)1.81601906
179ephrin receptor signaling pathway (GO:0048013)1.76113892
180antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.73507023
181antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.73507023
182alditol phosphate metabolic process (GO:0052646)1.70851256
183regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.70551043
184cell-substrate junction assembly (GO:0007044)1.67604780
185non-canonical Wnt signaling pathway (GO:0035567)1.67274711
186regulation of transforming growth factor beta2 production (GO:0032909)1.65083157
187cellular modified amino acid biosynthetic process (GO:0042398)1.64363144
188cardiac conduction (GO:0061337)1.57896868
189coronary vasculature morphogenesis (GO:0060977)1.56501185
190regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.55447864
191regulation of cardioblast proliferation (GO:0003264)1.54338696
192regulation of secondary heart field cardioblast proliferation (GO:0003266)1.54338696
193primary alcohol catabolic process (GO:0034310)1.53611661
194cardiac muscle cell action potential involved in contraction (GO:0086002)1.53206069
195wound healing, spreading of cells (GO:0044319)1.52596492
196negative regulation of epidermal cell differentiation (GO:0045605)1.50268168
197positive regulation of protein export from nucleus (GO:0046827)1.49971141
198G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.49793603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.26195674
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.27813737
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.02680392
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.34275823
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.32318513
6RUNX_20019798_ChIP-Seq_JUKART_Human3.88703409
7P63_26484246_Chip-Seq_KERATINOCYTES_Human3.55560922
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30157662
9MYB_26560356_Chip-Seq_TH2_Human3.08780381
10MYC_22102868_ChIP-Seq_BL_Human3.02496703
11MAF_26560356_Chip-Seq_TH1_Human2.93967279
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.81710963
13UTX_26944678_Chip-Seq_JUKART_Human2.81526094
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.81118209
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.69847159
16MYB_26560356_Chip-Seq_TH1_Human2.68993878
17VDR_21846776_ChIP-Seq_THP-1_Human2.68604487
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.64342758
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61975100
20MAF_26560356_Chip-Seq_TH2_Human2.48285665
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.45064866
22TCF7_22412390_ChIP-Seq_EML_Mouse2.42965889
23SCL_19346495_ChIP-Seq_HPC-7_Human2.42630680
24CTCF_20526341_ChIP-Seq_ESCs_Human2.39899168
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39895831
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38121976
27KDM2B_26808549_Chip-Seq_DND41_Human2.37425419
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.35136297
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33773637
30VDR_24763502_ChIP-Seq_THP-1_Human2.33532993
31NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.33185636
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31038545
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29777996
34KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25524581
35SPI1_23127762_ChIP-Seq_K562_Human2.15771911
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.15126910
37SPI1_23547873_ChIP-Seq_NB4_Human2.13463488
38GATA3_27048872_Chip-Seq_THYMUS_Human2.11713621
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09864599
40IRF8_27001747_Chip-Seq_BMDM_Mouse2.08883640
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07046919
42STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04761705
43TP63_17297297_ChIP-ChIP_HaCaT_Human12.5857613
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99694817
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.92827635
46* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.92655297
47TAF2_19829295_ChIP-Seq_ESCs_Human1.88984913
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.87880301
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87767552
50NANOG_20526341_ChIP-Seq_ESCs_Human1.79760974
51CSB_26484114_Chip-Seq_FIBROBLAST_Human1.79112701
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77963777
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76223766
54P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.73019858
55* E2F1_20622854_ChIP-Seq_HELA_Human1.72986791
56EGR1_19032775_ChIP-ChIP_M12_Human1.71253120
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68213806
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67822694
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64794933
60P53_21459846_ChIP-Seq_SAOS-2_Human1.63813535
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61840350
62MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.60624877
63CTCF_27219007_Chip-Seq_Bcells_Human1.59669193
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58840660
65ERG_20517297_ChIP-Seq_VCAP_Human1.57788649
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.53785222
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.52217180
68RACK7_27058665_Chip-Seq_MCF-7_Human1.51550646
69LXR_22292898_ChIP-Seq_THP-1_Human1.51464820
70TP63_22573176_ChIP-Seq_HFKS_Human1.50633242
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48237519
72BCL6_27268052_Chip-Seq_Bcells_Human1.47771373
73GATA3_26560356_Chip-Seq_TH2_Human1.47760219
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43992003
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43989408
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.42635462
77BCOR_27268052_Chip-Seq_Bcells_Human1.40412282
78ATF3_27146783_Chip-Seq_COLON_Human1.39799346
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39719715
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39486613
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37780629
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.36655779
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35092355
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33981381
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33981381
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33151902
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32444139
88VDR_24787735_ChIP-Seq_THP-1_Human1.31809231
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.31070060
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30370055
91PHF8_20622854_ChIP-Seq_HELA_Human1.30323112
92AHR_22903824_ChIP-Seq_MCF-7_Human1.28567874
93GATA1_19941826_ChIP-Seq_K562_Human1.28176599
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.26110263
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25408288
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25052523
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24942747
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24541296
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23951072
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.22658226
101E2F1_17053090_ChIP-ChIP_MCF-7_Human1.21373553
102CIITA_25753668_ChIP-Seq_RAJI_Human1.21248377
103P68_20966046_ChIP-Seq_HELA_Human1.19334294
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18326951
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17974513
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17851945
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17644273
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16958330
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16843782
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16722224
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16654914
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16397203
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.16296139
114RAC3_21632823_ChIP-Seq_H3396_Human1.15827685
115ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14486128
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14217053
117SMC4_20622854_ChIP-Seq_HELA_Human1.13316453
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12791459
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11830078
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10819974
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10418134
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10385715
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09550698
124GATA3_24758297_ChIP-Seq_MCF-7_Human1.09383900
125UBF1/2_26484160_Chip-Seq_HMECs_Human1.09278614
126PU_27001747_Chip-Seq_BMDM_Mouse1.08465887
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08154289
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08057999
129GATA4_25053715_ChIP-Seq_YYC3_Human1.07576166
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07190526
131TP63_23658742_ChIP-Seq_EP156T_Human1.06385185
132PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06245439
133GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05646599
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05626963
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05231031
136JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05169892
137NCOR1_26117541_ChIP-Seq_K562_Human1.04543391
138SOX2_21211035_ChIP-Seq_LN229_Human1.03776886
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01391298
140KLF5_25053715_ChIP-Seq_YYC3_Human1.01325954
141TRIM28_21343339_ChIP-Seq_HEK293_Human1.00205155
142* CEBPB_22108803_ChIP-Seq_LS180_Human0.99114678
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98618237
144SA1_27219007_Chip-Seq_ERYTHROID_Human0.98398994
145RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98220260
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97913046
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97005326
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96908567
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96454388
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95933883
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95853842
152FOXH1_21741376_ChIP-Seq_ESCs_Human0.95250005
153TP53_18474530_ChIP-ChIP_U2OS_Human0.93731906
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.93645643
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93134655
156GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92861772
157CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89022826
158BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88300255
159TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88255600
160P300_27268052_Chip-Seq_Bcells_Human0.88228095
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88157488
162RING1B_27294783_Chip-Seq_ESCs_Mouse0.87796797
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.87037040
164NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84397781
165CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84397216
166RXR_22108803_ChIP-Seq_LS180_Human0.83838632
167GATA6_21074721_ChIP-Seq_CACO-2_Human0.83114343
168SOX2_20726797_ChIP-Seq_SW620_Human0.83030192
169RNF2_27304074_Chip-Seq_ESCs_Mouse0.82068015
170ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81342843
171TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80806887
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78646529
173BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77847272
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77519023
175FOXA1_25329375_ChIP-Seq_VCAP_Human0.76441203
176FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76441203
177EZH2_27294783_Chip-Seq_ESCs_Mouse0.76201622
178* SPI1_20517297_ChIP-Seq_HL60_Human0.75874689
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75659823
180ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74958848
181ELK3_25401928_ChIP-Seq_HUVEC_Human0.73708095
182VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.71740387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.93731513
2MP0002098_abnormal_vibrissa_morphology7.54664021
3MP0000647_abnormal_sebaceous_gland6.63303829
4MP0002796_impaired_skin_barrier5.41021106
5MP0010234_abnormal_vibrissa_follicle5.14701875
6MP0005275_abnormal_skin_tensile4.83999863
7MP0000383_abnormal_hair_follicle4.76971294
8MP0000377_abnormal_hair_follicle4.21895507
9MP0010678_abnormal_skin_adnexa4.21294213
10MP0003436_decreased_susceptibility_to3.93901289
11MP0003705_abnormal_hypodermis_morpholog3.68995038
12MP0003724_increased_susceptibility_to3.64976408
13MP0000427_abnormal_hair_cycle3.60892171
14MP0005501_abnormal_skin_physiology3.40487898
15MP0001800_abnormal_humoral_immune3.25286836
16MP0001835_abnormal_antigen_presentation3.16941270
17MP0005671_abnormal_response_to3.12390386
18MP0002254_reproductive_system_inflammat2.96470239
19MP0005000_abnormal_immune_tolerance2.88138960
20MP0002396_abnormal_hematopoietic_system2.87097480
21MP0002420_abnormal_adaptive_immunity2.75473052
22MP0001819_abnormal_immune_cell2.71466671
23MP0002723_abnormal_immune_serum2.64957227
24MP0003303_peritoneal_inflammation2.63368599
25MP0002419_abnormal_innate_immunity2.62148535
26MP0001790_abnormal_immune_system2.61889115
27MP0005387_immune_system_phenotype2.61889115
28MP0000685_abnormal_immune_system2.60873105
29MP0001216_abnormal_epidermal_layer2.55962864
30MP0004381_abnormal_hair_follicle2.55300600
31MP0005025_abnormal_response_to2.52707804
32MP0000703_abnormal_thymus_morphology2.52191913
33MP0002452_abnormal_antigen_presenting2.50713088
34MP0000367_abnormal_coat/_hair2.41908594
35MP0002398_abnormal_bone_marrow2.41133151
36MP0009333_abnormal_splenocyte_physiolog2.34650924
37MP0003453_abnormal_keratinocyte_physiol2.19270521
38MP0000716_abnormal_immune_system2.18185233
39MP0004947_skin_inflammation2.17481851
40MP0010771_integument_phenotype2.16668299
41MP0002405_respiratory_system_inflammati2.13706401
42MP0001243_abnormal_dermal_layer2.13504527
43MP0009785_altered_susceptibility_to2.01837338
44MP0002722_abnormal_immune_system2.00746955
45MP0002234_abnormal_pharynx_morphology2.00302836
46MP0002060_abnormal_skin_morphology1.99828873
47MP0006082_CNS_inflammation1.92995923
48MP0000689_abnormal_spleen_morphology1.90985283
49MP0003866_abnormal_defecation1.87274561
50MP0005464_abnormal_platelet_physiology1.85104840
51MP0010155_abnormal_intestine_physiology1.79951165
52MP0001873_stomach_inflammation1.78317282
53MP0005410_abnormal_fertilization1.71831909
54MP0002132_abnormal_respiratory_system1.71804051
55MP0000467_abnormal_esophagus_morphology1.71724761
56MP0001533_abnormal_skeleton_physiology1.71071324
57MP0002429_abnormal_blood_cell1.70087733
58MP0009053_abnormal_anal_canal1.56430740
59MP0002148_abnormal_hypersensitivity_rea1.55300877
60MP0005310_abnormal_salivary_gland1.51281186
61MP0001845_abnormal_inflammatory_respons1.47416195
62MP0000762_abnormal_tongue_morphology1.46712806
63MP0003566_abnormal_cell_adhesion1.43324974
64MP0009931_abnormal_skin_appearance1.42868855
65MP0005409_darkened_coat_color1.38444222
66MP0008961_abnormal_basal_metabolism1.32423912
67MP0003828_pulmonary_edema1.32062724
68MP0003878_abnormal_ear_physiology1.31353270
69MP0005377_hearing/vestibular/ear_phenot1.31353270
70MP0002009_preneoplasia1.28144017
71MP0003172_abnormal_lysosome_physiology1.25388538
72MP0009278_abnormal_bone_marrow1.24982773
73MP0004510_myositis1.21094662
74MP0005083_abnormal_biliary_tract1.19138493
75MP0008469_abnormal_protein_level1.14976520
76MP0002998_abnormal_bone_remodeling1.09160053
77MP0002933_joint_inflammation1.09132724
78MP0000858_altered_metastatic_potential1.08977923
79MP0004808_abnormal_hematopoietic_stem1.06877996
80MP0003941_abnormal_skin_development1.06305740
81MP0001348_abnormal_lacrimal_gland0.99326188
82MP0001853_heart_inflammation0.95815818
83MP0002277_abnormal_respiratory_mucosa0.95257422
84MP0004885_abnormal_endolymph0.95141889
85MP0004883_abnormal_blood_vessel0.93410296
86MP0000490_abnormal_crypts_of0.92893034
87MP0008260_abnormal_autophagy0.92879029
88MP0001191_abnormal_skin_condition0.91001617
89MP0004264_abnormal_extraembryonic_tissu0.86914149
90MP0005397_hematopoietic_system_phenotyp0.85196400
91MP0001545_abnormal_hematopoietic_system0.85196400
92MP0001986_abnormal_taste_sensitivity0.83680552
93MP0001661_extended_life_span0.83087732
94MP0009115_abnormal_fat_cell0.82361569
95MP0008057_abnormal_DNA_replication0.81385965
96MP0001851_eye_inflammation0.80429064
97MP0003183_abnormal_peptide_metabolism0.79996224
98MP0004185_abnormal_adipocyte_glucose0.79989734
99MP0002095_abnormal_skin_pigmentation0.78050198
100MP0009764_decreased_sensitivity_to0.77761494
101MP0008004_abnormal_stomach_pH0.77253317
102MP0002138_abnormal_hepatobiliary_system0.77148364
103MP0004130_abnormal_muscle_cell0.72469697
104MP0003315_abnormal_perineum_morphology0.71694852
105MP0003690_abnormal_glial_cell0.71303124
106MP0002019_abnormal_tumor_incidence0.70512248
107MP0002877_abnormal_melanocyte_morpholog0.69556821
108MP0005166_decreased_susceptibility_to0.67290006
109MP0000015_abnormal_ear_pigmentation0.67234942
110MP0001663_abnormal_digestive_system0.66678195
111MP0001849_ear_inflammation0.64935873
112MP0001340_abnormal_eyelid_morphology0.63826351
113MP0009763_increased_sensitivity_to0.61546576
114MP0000249_abnormal_blood_vessel0.61429614
115MP0001346_abnormal_lacrimal_gland0.61249649
116MP0000566_synostosis0.60990226
117MP0008438_abnormal_cutaneous_collagen0.60010870
118MP0005164_abnormal_response_to0.59846859
119MP0003698_abnormal_male_reproductive0.57197088
120MP0010030_abnormal_orbit_morphology0.56114927
121MP0008874_decreased_physiological_sensi0.55460684
122MP0003091_abnormal_cell_migration0.55409675
123MP0000627_abnormal_mammary_gland0.54978004
124MP0001929_abnormal_gametogenesis0.54083844
125MP0009765_abnormal_xenobiotic_induced0.53211067
126MP0005390_skeleton_phenotype0.53092766
127MP0002282_abnormal_trachea_morphology0.52251975
128MP0002970_abnormal_white_adipose0.51730421
129MP0005535_abnormal_body_temperature0.50457134
130MP0003755_abnormal_palate_morphology0.50070022
131MP0003191_abnormal_cellular_cholesterol0.49367297
132MP0003795_abnormal_bone_structure0.49187835
133MP0002928_abnormal_bile_duct0.48791983
134MP0008569_lethality_at_weaning0.48427907
135MP0005023_abnormal_wound_healing0.47465762
136MP0002127_abnormal_cardiovascular_syste0.47197604
137MP0005451_abnormal_body_composition0.44273542
138MP0009840_abnormal_foam_cell0.41786073
139MP0002249_abnormal_larynx_morphology0.40405518
140MP0001784_abnormal_fluid_regulation0.39983883
141MP0002111_abnormal_tail_morphology0.39230189
142MP0005075_abnormal_melanosome_morpholog0.38504123
143MP0000678_abnormal_parathyroid_gland0.36319001
144MP0010352_gastrointestinal_tract_polyps0.34767136
145MP0004272_abnormal_basement_membrane0.31137413
146MP0003763_abnormal_thymus_physiology0.28570407
147MP0003385_abnormal_body_wall0.28471124
148MP0000537_abnormal_urethra_morphology0.28252634
149MP0003329_amyloid_beta_deposits0.25434201
150MP0002697_abnormal_eye_size0.24341769
151MP0003950_abnormal_plasma_membrane0.22914190
152MP0005248_abnormal_Harderian_gland0.22439509
153MP0002177_abnormal_outer_ear0.21250761
154MP0000465_gastrointestinal_hemorrhage0.20703317
155MP0003300_gastrointestinal_ulcer0.20337793
156MP0000432_abnormal_head_morphology0.18105885
157MP0004019_abnormal_vitamin_homeostasis0.17737378
158MP0004742_abnormal_vestibular_system0.16303348
159MP0003935_abnormal_craniofacial_develop0.15628333
160MP0006054_spinal_hemorrhage0.14886291
161MP0003638_abnormal_response/metabolism_0.13739025
162MP0004858_abnormal_nervous_system0.13425299
163MP0002233_abnormal_nose_morphology0.13164251
164MP0001879_abnormal_lymphatic_vessel0.12960799
165MP0000516_abnormal_urinary_system0.12906461
166MP0005367_renal/urinary_system_phenotyp0.12906461
167MP0000604_amyloidosis0.12705785
168MP0003448_altered_tumor_morphology0.12245566
169MP0005375_adipose_tissue_phenotype0.11608999
170MP0005193_abnormal_anterior_eye0.10391585
171MP0002006_tumorigenesis0.10209868
172MP0003075_altered_response_to0.10184768
173MP0009384_cardiac_valve_regurgitation0.09754856
174MP0005666_abnormal_adipose_tissue0.09689716
175MP0005076_abnormal_cell_differentiation0.08833011
176MP0005165_increased_susceptibility_to0.08628438
177MP0010368_abnormal_lymphatic_system0.07496760
178MP0000462_abnormal_digestive_system0.07267098
179MP0003011_delayed_dark_adaptation0.07205105
180MP0000013_abnormal_adipose_tissue0.06792077
181MP0002166_altered_tumor_susceptibility0.06372982
182MP0003045_fibrosis0.05697122
183MP0005452_abnormal_adipose_tissue0.05394809
184MP0006138_congestive_heart_failure0.05256106
185MP0001730_embryonic_growth_arrest0.05102874
186MP0005508_abnormal_skeleton_morphology0.05025729

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.48146406
2Nail dystrophy (HP:0008404)7.47402882
3Eczematoid dermatitis (HP:0000976)6.93099513
4Abnormality of nail color (HP:0100643)6.06920135
5Abnormal hair laboratory examination (HP:0003328)5.99272413
6Fine hair (HP:0002213)5.56052498
7Fragile nails (HP:0001808)5.49668777
8Stomatitis (HP:0010280)4.95915582
9Alopecia of scalp (HP:0002293)4.86933619
10Recurrent bacterial skin infections (HP:0005406)4.81281004
11Myositis (HP:0100614)4.76488530
12Recurrent abscess formation (HP:0002722)4.75910189
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.65567199
14T lymphocytopenia (HP:0005403)4.61217755
15Follicular hyperkeratosis (HP:0007502)4.59178196
16Onycholysis (HP:0001806)4.57891396
17Palmoplantar hyperkeratosis (HP:0000972)4.52443393
18Elevated erythrocyte sedimentation rate (HP:0003565)4.49595053
19Thick nail (HP:0001805)4.48842172
20Pustule (HP:0200039)4.42619451
21Palmar hyperkeratosis (HP:0010765)4.25289283
22Abnormality of T cell number (HP:0011839)4.24266454
23Recurrent fungal infections (HP:0002841)4.22685458
24Panhypogammaglobulinemia (HP:0003139)4.14606323
25Right ventricular cardiomyopathy (HP:0011663)4.13600097
26Plantar hyperkeratosis (HP:0007556)4.11173984
27Abnormality of macrophages (HP:0004311)4.06143769
28Prolonged bleeding time (HP:0003010)3.86471796
29Increased IgE level (HP:0003212)3.85750279
30Papilledema (HP:0001085)3.83575824
31Orchitis (HP:0100796)3.80427658
32Spontaneous hematomas (HP:0007420)3.78975873
33Meningitis (HP:0001287)3.77998861
34Obstructive lung disease (HP:0006536)3.73869941
35Chronic obstructive pulmonary disease (HP:0006510)3.73869941
36Gastrointestinal infarctions (HP:0005244)3.69267251
37Sparse eyelashes (HP:0000653)3.68860878
38Optic neuritis (HP:0100653)3.67775322
39Retrobulbar optic neuritis (HP:0100654)3.67775322
40Recurrent gram-negative bacterial infections (HP:0005420)3.64930670
41Abnormality of T cells (HP:0002843)3.63619501
42Mediastinal lymphadenopathy (HP:0100721)3.45600867
43Encephalitis (HP:0002383)3.39964333
44Granulocytopenia (HP:0001913)3.32492692
45Oral leukoplakia (HP:0002745)3.32037630
46Recurrent skin infections (HP:0001581)3.31631006
47Vasculitis (HP:0002633)3.27570467
48Chest pain (HP:0100749)3.24545739
49Inflammation of the large intestine (HP:0002037)3.20169824
50Hypochromic microcytic anemia (HP:0004840)3.19914539
51Erythema (HP:0010783)3.19563843
52Gastrointestinal inflammation (HP:0004386)3.18465884
53Milia (HP:0001056)3.18275260
54Amelogenesis imperfecta (HP:0000705)3.16202636
55Chronic mucocutaneous candidiasis (HP:0002728)3.13476885
56Recurrent cutaneous fungal infections (HP:0011370)3.13476885
57Recurrent viral infections (HP:0004429)3.11174341
58Hypochromic anemia (HP:0001931)3.10823692
59Abnormality of the frontal sinuses (HP:0002687)3.09230647
60Lymphopenia (HP:0001888)3.07891482
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.01085485
62Leukocytosis (HP:0001974)3.00900674
63Severe combined immunodeficiency (HP:0004430)3.00636249
64Gingivitis (HP:0000230)2.98395721
65Parakeratosis (HP:0001036)2.98149221
66Congenital, generalized hypertrichosis (HP:0004540)2.88862758
67Verrucae (HP:0200043)2.86077873
68Papilloma (HP:0012740)2.86077873
69Abnormality of T cell physiology (HP:0011840)2.83193523
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.83008123
71Cellulitis (HP:0100658)2.80069667
72Eosinophilia (HP:0001880)2.78744211
73Intention tremor (HP:0002080)2.76539747
74IgM deficiency (HP:0002850)2.75197714
75Curly hair (HP:0002212)2.72326179
76Colitis (HP:0002583)2.68285464
77Ridged nail (HP:0001807)2.67586353
78Urticaria (HP:0001025)2.66007466
79Epistaxis (HP:0000421)2.64771361
80Increased IgM level (HP:0003496)2.62969177
81Torticollis (HP:0000473)2.60461628
82Slow saccadic eye movements (HP:0000514)2.59222256
83Pulmonary infiltrates (HP:0002113)2.55120090
84Abnormality of the fingertips (HP:0001211)2.53134185
85Abnormality of eosinophils (HP:0001879)2.53053531
86Basal cell carcinoma (HP:0002671)2.49782905
87Hemoptysis (HP:0002105)2.47269750
88Neck muscle weakness (HP:0000467)2.47117255
89Combined immunodeficiency (HP:0005387)2.45356903
90Erythroderma (HP:0001019)2.43334349
91Natal tooth (HP:0000695)2.43168844
92Autoimmune hemolytic anemia (HP:0001890)2.42576070
93Nasal polyposis (HP:0100582)2.41120221
94Dry hair (HP:0011359)2.39635173
95Recurrent bronchitis (HP:0002837)2.39415641
96Aplasia cutis congenita (HP:0001057)2.38042176
97Episodic fever (HP:0001954)2.37594812
98Pulmonary embolism (HP:0002204)2.37006976
99Hypoplasia of the thymus (HP:0000778)2.34727620
100Advanced eruption of teeth (HP:0006288)2.28607252
101Gingival bleeding (HP:0000225)2.27161342
102Microcytic anemia (HP:0001935)2.25842783
103Agammaglobulinemia (HP:0004432)2.22387325
104Abnormal blistering of the skin (HP:0008066)2.22347366
105Craniofacial dystonia (HP:0012179)2.20631323
106Congenital ichthyosiform erythroderma (HP:0007431)2.14887091
107Seborrheic dermatitis (HP:0001051)2.13277835
108IgG deficiency (HP:0004315)2.11377960
109Arterial thrombosis (HP:0004420)2.11213951
110Sepsis (HP:0100806)2.10336389
111Aplasia/Hypoplasia of the thymus (HP:0010515)2.07576017
112Skin ulcer (HP:0200042)2.05884833
113Gangrene (HP:0100758)2.03878214
114Focal dystonia (HP:0004373)2.02006460
115Osteomyelitis (HP:0002754)2.00693999
116Subacute progressive viral hepatitis (HP:0006572)2.00150316
117Hypotrichosis (HP:0001006)14.9134299
118Abnormality of hair growth rate (HP:0011363)11.7421950
119Slow-growing hair (HP:0002217)11.7421950
120Woolly hair (HP:0002224)11.4441054
121Brittle hair (HP:0002299)10.8462983
122Hypohidrosis (HP:0000966)1.99622146
123Anorexia (HP:0002039)1.98782728
124Viral hepatitis (HP:0006562)1.98771713
125Acute hepatic failure (HP:0006554)1.96678246
126Joint swelling (HP:0001386)1.96614853
127Difficulty walking (HP:0002355)1.94934119
128Abnormality of the pupil (HP:0000615)1.92145768
129Abnormality of the pleura (HP:0002103)1.91911118
130Ventricular tachycardia (HP:0004756)1.91431895
131Corneal erosion (HP:0200020)1.91197995
132Abnormality of the nasal mucosa (HP:0000433)1.89774507
133Gastrointestinal stroma tumor (HP:0100723)1.87189069
134Abnormality of the dental root (HP:0006486)1.87148336
135Taurodontia (HP:0000679)1.87148336
136Abnormality of permanent molar morphology (HP:0011071)1.87148336
137Pruritus (HP:0000989)1.86153329
138Severe visual impairment (HP:0001141)1.85547932
139Palmoplantar keratoderma (HP:0000982)1.85322437
140Glomerulopathy (HP:0100820)1.84277868
141Ventricular fibrillation (HP:0001663)1.84233389
142Abnormality of molar morphology (HP:0011070)1.82465343
143Abnormality of molar (HP:0011077)1.82465343
144Abnormality of the parietal bone (HP:0002696)1.81834382
145Lymphoma (HP:0002665)1.81236371
146Petechiae (HP:0000967)1.79008499
147Abnormal platelet volume (HP:0011876)1.77919905
148Autoimmune thrombocytopenia (HP:0001973)1.77537697
149Abnormality of dental color (HP:0011073)1.76316595
150Concave nail (HP:0001598)1.75366028
151Asymmetric septal hypertrophy (HP:0001670)1.74903501
152Absent eyelashes (HP:0000561)1.74743201
153Abnormality of the columella (HP:0009929)1.73147924
154Teleangiectasia of the skin (HP:0100585)1.72692704
155Hemiplegia (HP:0002301)1.71182458
156Widely patent fontanelles and sutures (HP:0004492)1.67473827
157Fatigable weakness (HP:0003473)1.64817249
158Abnormality of the neuromuscular junction (HP:0003398)1.64817249
159Abnormality of the dental pulp (HP:0006479)1.63449996
160Recurrent corneal erosions (HP:0000495)1.59998733
161Blepharitis (HP:0000498)1.54984279
162Abnormality of the aortic arch (HP:0012303)1.52483837
163Amniotic constriction ring (HP:0009775)1.52385070
164Abnormality of placental membranes (HP:0011409)1.52385070
165Unilateral renal agenesis (HP:0000122)1.48677540
166Heterogeneous (HP:0001425)1.45083646
167Sudden death (HP:0001699)1.44399125
168Acanthosis nigricans (HP:0000956)1.42050254
169Carious teeth (HP:0000670)1.37350002
170Hyporeflexia of lower limbs (HP:0002600)1.36167856
171Keratoconjunctivitis sicca (HP:0001097)1.34170706
172Lip pit (HP:0100267)1.33897421
173Anonychia (HP:0001798)1.32687909
174Craniofacial hyperostosis (HP:0004493)1.32130987
175Autoamputation (HP:0001218)1.30030755
176Neonatal onset (HP:0003623)1.27534826
177Achilles tendon contracture (HP:0001771)1.24443176
178Abnormality of the fingernails (HP:0001231)1.23887283
179Variable expressivity (HP:0003828)1.23278605
180Widely spaced teeth (HP:0000687)1.22690143
181Selective tooth agenesis (HP:0001592)1.22670793
182Sparse scalp hair (HP:0002209)1.20512548
183Keratoconjunctivitis (HP:0001096)1.17907304
184Laryngomalacia (HP:0001601)1.17807908
185Abnormality of the Achilles tendon (HP:0005109)1.17530846
186Distal lower limb muscle weakness (HP:0009053)1.14969710
187Ectropion (HP:0000656)1.14187859
188Hypergammaglobulinemia (HP:0010702)1.11266039
189Abnormality of the gastric mucosa (HP:0004295)1.10453508
190Epidermoid cyst (HP:0200040)1.08237757
191Wide cranial sutures (HP:0010537)1.06144303
192Furrowed tongue (HP:0000221)1.04739685
193Hyperhidrosis (HP:0000975)1.04137750
194Bronchomalacia (HP:0002780)1.03979100
195Lack of skin elasticity (HP:0100679)1.02690832
196Neonatal death (HP:0003811)1.02550380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.93867918
2MAP3K64.62077970
3EPHA24.37638400
4FER4.15979676
5MAPKAPK34.05843145
6ERN13.77087635
7RIPK43.44058631
8PRPF4B3.37086433
9TAOK13.11293458
10EPHB23.04937737
11TXK3.02298077
12MAP3K32.79632356
13TRIB32.67181260
14ZAP702.55573815
15MAP3K22.53453446
16LATS12.52635500
17TNK22.25226432
18FES2.24930239
19CSK2.22538455
20EEF2K2.07781059
21SIK32.07266051
22MAP3K132.01186669
23MAP3K111.99852507
24BTK1.94334476
25RPS6KB21.92051346
26JAK31.85505126
27NLK1.84037147
28ITK1.77078348
29LATS21.72807402
30SYK1.71750389
31HCK1.68965051
32EPHB11.68576145
33MARK31.67671695
34CAMKK21.67476475
35IRAK41.62144623
36MAP2K61.59244732
37SIK21.55837429
38LCK1.41521203
39SMG11.36557878
40FGFR41.33368897
41MAP3K141.31876494
42IKBKE1.29154616
43TTN1.28870000
44CAMKK11.27779940
45KSR21.27503592
46BCR1.26949351
47MARK21.25986442
48PIK3CG1.25431648
49MAP3K11.25347603
50PKN21.24965927
51CDK121.21730044
52FGFR21.21599339
53RIPK11.18850197
54TAOK31.18696152
55BMX1.18439777
56PASK1.17881830
57CDK61.17097495
58NME11.16509598
59BLK1.13779685
60FGFR31.13021591
61MAPKAPK21.08431599
62PDGFRA1.07041501
63LYN1.04814339
64BRD41.02011492
65PTK61.01163601
66MAP2K31.00522812
67HIPK21.00344688
68TEC0.99157019
69PDK10.97811185
70MAP3K70.96429298
71MAP3K90.95514425
72STK100.95164260
73MAP3K100.93463766
74LRRK20.91186542
75STK38L0.88732277
76MAP2K40.88728914
77RPS6KA40.84633824
78PTK20.83164758
79STK380.82261361
80MST1R0.82153081
81YES10.80014492
82PRKCQ0.79719209
83PIM20.79419860
84PAK30.78777069
85SIK10.77865679
86FGFR10.76195714
87ERBB40.75098525
88MAP2K10.74450591
89CDK40.73880345
90TBK10.72091421
91MAPK70.70768407
92CDC42BPA0.70153500
93FGR0.70132935
94PAK40.69686181
95PBK0.68810907
96TYK20.66218712
97TESK20.65568226
98PRKD10.64959411
99DYRK1B0.64801193
100IKBKB0.64667538
101DDR20.62038821
102WNK10.61291191
103PDPK10.60270856
104CDK190.60147608
105CSF1R0.60136804
106TESK10.59998463
107MAP3K50.56970794
108JAK10.56408212
109PRKCI0.55856810
110MELK0.55127465
111TRPM70.54205698
112PLK40.54050758
113TYRO30.53968094
114PRKD20.53810360
115PAK60.53717883
116PIM10.53436577
117MET0.52711163
118NEK20.52059352
119RET0.51824871
120PRKCH0.51088763
121PDGFRB0.50840189
122CAMK1D0.50161514
123RPS6KA10.49206723
124ERBB20.48781468
125TGFBR10.47985729
126PAK20.46214511
127NTRK20.45970495
128MAPK110.45036511
129CAMK40.43791523
130EPHA30.43465344
131KIT0.43436480
132CLK10.43383821
133GRK60.42258134
134ALK0.41033833
135CSNK1E0.40780862
136UHMK10.40024894
137SGK30.38844923
138GSK3A0.38760247
139MAPK120.38587702
140MAP2K20.36963366
141JAK20.35639351
142MST40.35565502
143MAP3K80.34046170
144ILK0.33887688
145RPS6KL10.33762627
146RPS6KC10.33762627
147STK240.33327437
148FYN0.30846879
149PTK2B0.30737621
150SGK20.30096829
151PHKG10.29943401
152PHKG20.29943401
153NEK60.29750341
154STK110.28544168
155NEK10.27182571
156ERBB30.27026788
157TGFBR20.24971315
158CSNK1G10.23827873
159CSNK1A10.23274391
160ABL20.22394286
161CSNK1A1L0.22033803
162CSNK1G30.21944662
163ROCK20.21901990
164PRKACG0.21735818

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.12567676
2Linoleic acid metabolism_Homo sapiens_hsa005915.09572870
3Fat digestion and absorption_Homo sapiens_hsa049753.29691494
4Primary immunodeficiency_Homo sapiens_hsa053403.24341567
5T cell receptor signaling pathway_Homo sapiens_hsa046602.85806303
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.76528888
7Ether lipid metabolism_Homo sapiens_hsa005652.72954431
8Osteoclast differentiation_Homo sapiens_hsa043802.51179700
9Graft-versus-host disease_Homo sapiens_hsa053322.45973566
10Fatty acid elongation_Homo sapiens_hsa000622.40467164
11B cell receptor signaling pathway_Homo sapiens_hsa046622.39955270
12Basal cell carcinoma_Homo sapiens_hsa052172.26988554
13Allograft rejection_Homo sapiens_hsa053302.13959063
14Autoimmune thyroid disease_Homo sapiens_hsa053202.06398105
15Leishmaniasis_Homo sapiens_hsa051401.93648693
16Arachidonic acid metabolism_Homo sapiens_hsa005901.92150625
17Measles_Homo sapiens_hsa051621.90146430
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.82009777
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.77838793
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76732689
21Phenylalanine metabolism_Homo sapiens_hsa003601.75424906
22Hematopoietic cell lineage_Homo sapiens_hsa046401.72360722
23VEGF signaling pathway_Homo sapiens_hsa043701.66737041
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.60954708
25Antigen processing and presentation_Homo sapiens_hsa046121.60100349
26Melanogenesis_Homo sapiens_hsa049161.57676190
27Chemokine signaling pathway_Homo sapiens_hsa040621.57109428
28Viral myocarditis_Homo sapiens_hsa054161.55902106
29Axon guidance_Homo sapiens_hsa043601.55575600
30Type I diabetes mellitus_Homo sapiens_hsa049401.52556206
31Caffeine metabolism_Homo sapiens_hsa002321.50804508
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47857678
33Hedgehog signaling pathway_Homo sapiens_hsa043401.42470674
34Histidine metabolism_Homo sapiens_hsa003401.39695351
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39074808
36Thyroid cancer_Homo sapiens_hsa052161.36958256
37Bladder cancer_Homo sapiens_hsa052191.35624576
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35109150
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34645923
40Herpes simplex infection_Homo sapiens_hsa051681.31840577
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31585892
42Glioma_Homo sapiens_hsa052141.31031444
43Hippo signaling pathway_Homo sapiens_hsa043901.30867242
44Malaria_Homo sapiens_hsa051441.29464272
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.28358705
46Hepatitis B_Homo sapiens_hsa051611.26914322
47Influenza A_Homo sapiens_hsa051641.25855978
48Proteoglycans in cancer_Homo sapiens_hsa052051.22164024
49Acute myeloid leukemia_Homo sapiens_hsa052211.20727341
50Pancreatic cancer_Homo sapiens_hsa052121.19437325
51GnRH signaling pathway_Homo sapiens_hsa049121.15995544
52Colorectal cancer_Homo sapiens_hsa052101.14463378
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12139182
54Dorso-ventral axis formation_Homo sapiens_hsa043201.11879357
55Pancreatic secretion_Homo sapiens_hsa049721.11589589
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10693356
57Mineral absorption_Homo sapiens_hsa049781.09783316
58Choline metabolism in cancer_Homo sapiens_hsa052311.09359997
59Tight junction_Homo sapiens_hsa045301.08843317
60Inositol phosphate metabolism_Homo sapiens_hsa005621.05166748
61TNF signaling pathway_Homo sapiens_hsa046681.04357944
62Nitrogen metabolism_Homo sapiens_hsa009101.03872900
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.02982241
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01050329
65PPAR signaling pathway_Homo sapiens_hsa033201.00790462
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00569537
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.99304415
68FoxO signaling pathway_Homo sapiens_hsa040680.98059431
69Long-term potentiation_Homo sapiens_hsa047200.97972068
70Adherens junction_Homo sapiens_hsa045200.96688980
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93295749
72Endometrial cancer_Homo sapiens_hsa052130.93102947
73HTLV-I infection_Homo sapiens_hsa051660.92934957
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.92329798
75Non-small cell lung cancer_Homo sapiens_hsa052230.92021287
76Apoptosis_Homo sapiens_hsa042100.91478663
77mTOR signaling pathway_Homo sapiens_hsa041500.89518972
78Steroid biosynthesis_Homo sapiens_hsa001000.89481756
79Epstein-Barr virus infection_Homo sapiens_hsa051690.88752655
80Tyrosine metabolism_Homo sapiens_hsa003500.86948824
81ECM-receptor interaction_Homo sapiens_hsa045120.86638750
82Ras signaling pathway_Homo sapiens_hsa040140.86239092
83Viral carcinogenesis_Homo sapiens_hsa052030.85720735
84beta-Alanine metabolism_Homo sapiens_hsa004100.83559258
85Other glycan degradation_Homo sapiens_hsa005110.82791815
86Olfactory transduction_Homo sapiens_hsa047400.82543388
87Prostate cancer_Homo sapiens_hsa052150.81844354
88African trypanosomiasis_Homo sapiens_hsa051430.81791481
89Estrogen signaling pathway_Homo sapiens_hsa049150.81089534
90Endocytosis_Homo sapiens_hsa041440.79470980
91Wnt signaling pathway_Homo sapiens_hsa043100.76890214
92Long-term depression_Homo sapiens_hsa047300.74517411
93Pertussis_Homo sapiens_hsa051330.73859249
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73612760
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.72976778
96MAPK signaling pathway_Homo sapiens_hsa040100.72835168
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72755988
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71838141
99Phagosome_Homo sapiens_hsa041450.71389663
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71252565
101Amoebiasis_Homo sapiens_hsa051460.70449207
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69483739
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.68471045
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65427547
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65039921
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64876412
107Legionellosis_Homo sapiens_hsa051340.64832524
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63807141
109Hepatitis C_Homo sapiens_hsa051600.63140548
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62216371
111MicroRNAs in cancer_Homo sapiens_hsa052060.62001008
112Type II diabetes mellitus_Homo sapiens_hsa049300.61461000
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60224776
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59764323
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.59560907
116Gastric acid secretion_Homo sapiens_hsa049710.58950016
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.58739579
118Gap junction_Homo sapiens_hsa045400.57940989
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57387192
120HIF-1 signaling pathway_Homo sapiens_hsa040660.56232498
121Insulin resistance_Homo sapiens_hsa049310.55888116
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.55777797
123Shigellosis_Homo sapiens_hsa051310.54934891
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54932622
125Asthma_Homo sapiens_hsa053100.54313701
126Rap1 signaling pathway_Homo sapiens_hsa040150.54164033
127TGF-beta signaling pathway_Homo sapiens_hsa043500.53266464
128Fatty acid metabolism_Homo sapiens_hsa012120.50651839
129Renin secretion_Homo sapiens_hsa049240.50423259
130Renal cell carcinoma_Homo sapiens_hsa052110.49870837
131ErbB signaling pathway_Homo sapiens_hsa040120.49836736
132Salmonella infection_Homo sapiens_hsa051320.49156513
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48815428
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48439252
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48433264
136Staphylococcus aureus infection_Homo sapiens_hsa051500.47990832
137Phototransduction_Homo sapiens_hsa047440.46866587
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.46010324
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45796914
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44170237
141Chronic myeloid leukemia_Homo sapiens_hsa052200.43132480
142Focal adhesion_Homo sapiens_hsa045100.42615349
143Regulation of autophagy_Homo sapiens_hsa041400.42288743
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41855812
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41778493
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41674283
147Butanoate metabolism_Homo sapiens_hsa006500.41410884
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41315448
149Prolactin signaling pathway_Homo sapiens_hsa049170.41148528
150Salivary secretion_Homo sapiens_hsa049700.41058603
151Notch signaling pathway_Homo sapiens_hsa043300.40478099
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39730647
153Prion diseases_Homo sapiens_hsa050200.39642266
154Chemical carcinogenesis_Homo sapiens_hsa052040.39501311
155Fatty acid degradation_Homo sapiens_hsa000710.39376621
156Oxytocin signaling pathway_Homo sapiens_hsa049210.39374841
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39360053
158Protein digestion and absorption_Homo sapiens_hsa049740.39080638
159Platelet activation_Homo sapiens_hsa046110.38763115
160Rheumatoid arthritis_Homo sapiens_hsa053230.37898326
161Primary bile acid biosynthesis_Homo sapiens_hsa001200.36505897
162Toxoplasmosis_Homo sapiens_hsa051450.35957893
163Arginine biosynthesis_Homo sapiens_hsa002200.35474581
164Melanoma_Homo sapiens_hsa052180.35183077
165Tuberculosis_Homo sapiens_hsa051520.33503639
166p53 signaling pathway_Homo sapiens_hsa041150.33404039
167Dopaminergic synapse_Homo sapiens_hsa047280.33265828

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