KRT73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.67656373
2adhesion of symbiont to host cell (GO:0044650)9.67656373
3citrulline biosynthetic process (GO:0019240)8.65582528
4peptide cross-linking (GO:0018149)8.27234915
5adhesion of symbiont to host (GO:0044406)8.12125897
6hair follicle morphogenesis (GO:0031069)8.05473046
7positive regulation of gamma-delta T cell activation (GO:0046645)7.14614191
8intermediate filament cytoskeleton organization (GO:0045104)6.67380653
9cell wall macromolecule catabolic process (GO:0016998)6.61520523
10cell wall macromolecule metabolic process (GO:0044036)6.61520523
11response to interleukin-15 (GO:0070672)6.58223540
12intermediate filament-based process (GO:0045103)6.45856133
13negative regulation of cell killing (GO:0031342)6.32114079
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.32114079
15epidermis development (GO:0008544)6.27574770
16negative thymic T cell selection (GO:0045060)6.26951350
17negative T cell selection (GO:0043383)6.16051011
18negative regulation of erythrocyte differentiation (GO:0045647)6.11994871
19cellular response to interleukin-15 (GO:0071350)6.04731715
20keratinocyte differentiation (GO:0030216)5.95040102
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.93376345
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.80794479
23positive T cell selection (GO:0043368)5.79427254
24regulation of gamma-delta T cell differentiation (GO:0045586)5.78952748
25citrulline metabolic process (GO:0000052)5.70836215
26establishment of skin barrier (GO:0061436)5.68818814
27hair cycle process (GO:0022405)5.50889847
28molting cycle process (GO:0022404)5.50889847
29regulation of gamma-delta T cell activation (GO:0046643)5.50117428
30positive thymic T cell selection (GO:0045059)5.44727296
31thymic T cell selection (GO:0045061)5.41867481
32bundle of His cell to Purkinje myocyte communication (GO:0086069)5.34399647
33T cell selection (GO:0045058)5.31789325
34positive regulation of granulocyte differentiation (GO:0030854)5.26474842
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.24386539
36hemidesmosome assembly (GO:0031581)5.21767929
37activated T cell proliferation (GO:0050798)5.11013562
38antigen processing and presentation of endogenous antigen (GO:0019883)5.06274899
39peptidyl-arginine modification (GO:0018195)5.04415512
40regulation of water loss via skin (GO:0033561)5.04305068
41leukocyte aggregation (GO:0070486)5.04232811
42regulation of B cell receptor signaling pathway (GO:0050855)5.03939592
43skin morphogenesis (GO:0043589)4.95750174
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.78197595
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.78183579
46epidermal cell differentiation (GO:0009913)4.66394852
47negative regulation of T cell mediated immunity (GO:0002710)4.44602974
48tolerance induction (GO:0002507)4.15879196
49negative regulation of lymphocyte mediated immunity (GO:0002707)4.14406391
50keratinocyte development (GO:0003334)4.11832896
51tooth mineralization (GO:0034505)4.05945158
52T cell migration (GO:0072678)4.05256746
53hair cycle (GO:0042633)33.3381225
54molting cycle (GO:0042303)33.3381225
55regulation of T cell tolerance induction (GO:0002664)3.93097878
56positive regulation of tolerance induction (GO:0002645)3.86378879
57regulation of granulocyte differentiation (GO:0030852)3.83893035
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.80298682
59negative regulation of T-helper cell differentiation (GO:0045623)3.73448962
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.73448962
61negative regulation of keratinocyte proliferation (GO:0010839)3.71764329
62regulation of tolerance induction (GO:0002643)3.69658656
63negative regulation of leukocyte mediated immunity (GO:0002704)3.68860294
64hair follicle development (GO:0001942)3.64675701
65mast cell activation (GO:0045576)3.59401438
66interferon-gamma production (GO:0032609)3.53132063
67T cell homeostasis (GO:0043029)3.51409262
68positive regulation of hair follicle development (GO:0051798)3.51318868
69positive regulation of hair cycle (GO:0042635)3.51318868
70B cell receptor signaling pathway (GO:0050853)3.49863455
71alpha-beta T cell differentiation (GO:0046632)3.44638011
72regulation of alpha-beta T cell proliferation (GO:0046640)3.42924841
73negative regulation of interleukin-12 production (GO:0032695)3.41412535
74regulation of B cell differentiation (GO:0045577)3.41198234
75T cell receptor signaling pathway (GO:0050852)3.39622189
76positive regulation of meiotic cell cycle (GO:0051446)3.39382889
77mast cell degranulation (GO:0043303)3.38639114
78mast cell activation involved in immune response (GO:0002279)3.38639114
79histone H3-K36 demethylation (GO:0070544)3.38115860
80multicellular organismal water homeostasis (GO:0050891)3.37715266
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37231614
82positive regulation by organism of defense response of other organism involved in symbiotic interact3.37231614
83modulation by symbiont of host immune response (GO:0052553)3.37231614
84positive regulation by symbiont of host defense response (GO:0052509)3.37231614
85modulation by symbiont of host defense response (GO:0052031)3.37231614
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37231614
87bone trabecula formation (GO:0060346)3.35303488
88detection of bacterium (GO:0016045)3.35048149
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.32262478
90regulation of hair follicle development (GO:0051797)3.32112402
91antigen receptor-mediated signaling pathway (GO:0050851)3.29328079
92regulation of interleukin-2 biosynthetic process (GO:0045076)3.28842847
93detection of other organism (GO:0098543)3.28827833
94embryonic process involved in female pregnancy (GO:0060136)3.26963212
95regulation of keratinocyte differentiation (GO:0045616)3.23919965
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20399216
97alpha-beta T cell activation (GO:0046631)3.19699954
98cellular extravasation (GO:0045123)3.18334356
99lymphocyte homeostasis (GO:0002260)3.17533452
100Peyers patch development (GO:0048541)3.16841169
101mucosal-associated lymphoid tissue development (GO:0048537)3.16841169
102ectoderm development (GO:0007398)3.15825658
103regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15784987
104regulation of regulatory T cell differentiation (GO:0045589)3.11891281
105JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.10719825
106negative regulation of adaptive immune response (GO:0002820)3.10569182
107positive regulation of B cell differentiation (GO:0045579)3.09716804
108natural killer cell differentiation (GO:0001779)3.09697956
109response to muramyl dipeptide (GO:0032495)3.09665698
110phosphatidylinositol acyl-chain remodeling (GO:0036149)3.07703733
111regulation of isotype switching to IgG isotypes (GO:0048302)3.06677420
112negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.06539016
113positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04913781
114leukocyte degranulation (GO:0043299)3.03495912
115regulation of natural killer cell mediated immunity (GO:0002715)3.02360356
116regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.02360356
117negative regulation of type 2 immune response (GO:0002829)3.01069540
118epithelium development (GO:0060429)2.99925606
119positive regulation of interleukin-2 production (GO:0032743)2.97774587
120regulation of hair cycle (GO:0042634)2.95284785
121negative regulation of glycoprotein biosynthetic process (GO:0010561)2.94075032
122regulation of interleukin-4 production (GO:0032673)2.92802742
123germinal center formation (GO:0002467)2.88645864
124negative regulation of phagocytosis (GO:0050765)2.87783802
125T cell differentiation (GO:0030217)2.84312087
126negative regulation of protein localization to plasma membrane (GO:1903077)2.84133258
127negative regulation of cytokine production involved in immune response (GO:0002719)2.83186943
128positive regulation of epidermis development (GO:0045684)2.82567544
129megakaryocyte development (GO:0035855)2.82271136
130interferon-gamma secretion (GO:0072643)2.82118313
131water homeostasis (GO:0030104)2.82010790
132CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.80881156
133myeloid cell activation involved in immune response (GO:0002275)2.80302826
134phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79817616
135antigen processing and presentation via MHC class Ib (GO:0002475)2.78713332
136regulation of T cell mediated cytotoxicity (GO:0001914)2.75671915
137positive regulation of natural killer cell differentiation (GO:0032825)2.74411671
138regulation of alpha-beta T cell activation (GO:0046634)2.72719155
139T-helper cell differentiation (GO:0042093)2.72454078
140CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.72454078
141response to laminar fluid shear stress (GO:0034616)2.71593726
142atrioventricular valve morphogenesis (GO:0003181)2.70743819
143epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.70379143
144fatty acid elongation (GO:0030497)2.70253718
145phosphatidylserine acyl-chain remodeling (GO:0036150)2.69317813
146gap junction assembly (GO:0016264)2.67330008
147planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65767722
148phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.59496310
149ventricular cardiac muscle cell action potential (GO:0086005)2.57433917
150cell surface receptor signaling pathway involved in heart development (GO:0061311)2.54261776
151establishment of planar polarity (GO:0001736)2.50829000
152establishment of tissue polarity (GO:0007164)2.50829000
153regulation of epidermis development (GO:0045682)2.47993342
154regulation of epidermal cell differentiation (GO:0045604)2.47479777
155negative regulation of cell fate specification (GO:0009996)2.45284257
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43894677
157cranial suture morphogenesis (GO:0060363)2.38411872
158wound healing, spreading of epidermal cells (GO:0035313)2.33930214
159regulation of mesenchymal cell apoptotic process (GO:2001053)2.31390140
160lateral sprouting from an epithelium (GO:0060601)2.30473273
161regulation of heart rate by cardiac conduction (GO:0086091)2.29981275
162myotube differentiation (GO:0014902)2.26889374
163skin development (GO:0043588)2.25286785
164positive regulation of epidermal cell differentiation (GO:0045606)2.23048510
165lymph vessel development (GO:0001945)2.20751852
166non-canonical Wnt signaling pathway (GO:0035567)2.18331737
167regulation of keratinocyte proliferation (GO:0010837)2.17415830
168cardiac right ventricle morphogenesis (GO:0003215)2.16015533
169regulation of cardioblast differentiation (GO:0051890)2.14219088
170outflow tract septum morphogenesis (GO:0003148)2.13336946
171negative regulation of epidermis development (GO:0045683)2.11533042
172phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.10392257
173positive regulation of meiosis (GO:0045836)2.07104402
174phosphatidylserine metabolic process (GO:0006658)2.03835185
175positive regulation of monocyte chemotaxis (GO:0090026)2.02160192
176regulation of ruffle assembly (GO:1900027)2.00491791
177intermediate filament organization (GO:0045109)12.0678871
178keratinization (GO:0031424)11.1370717
179desmosome organization (GO:0002934)10.6078697
180cell communication involved in cardiac conduction (GO:0086065)1.97955003
181regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.96805344
182cytoskeletal anchoring at plasma membrane (GO:0007016)1.96524201
183regulation of transforming growth factor beta2 production (GO:0032909)1.96506934
184ephrin receptor signaling pathway (GO:0048013)1.95637637
185aging (GO:0007568)1.93146526
186craniofacial suture morphogenesis (GO:0097094)1.92863219
187epithelial cell-cell adhesion (GO:0090136)1.86601268
188phosphatidylcholine acyl-chain remodeling (GO:0036151)1.83802360
189eyelid development in camera-type eye (GO:0061029)1.82554313
190cardiac conduction (GO:0061337)1.79044596
191G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.78834961
192cardiac muscle cell action potential involved in contraction (GO:0086002)1.77364492
193cell-substrate junction assembly (GO:0007044)1.76239050
194negative regulation of Ras GTPase activity (GO:0034261)1.74400322
195Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.73390188
196dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.71769926
197cardiac muscle cell action potential (GO:0086001)1.71086765
198oocyte development (GO:0048599)1.70671946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.55245646
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.98554398
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37192812
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.73139952
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.67119120
6RUNX_20019798_ChIP-Seq_JUKART_Human4.23615505
7P63_26484246_Chip-Seq_KERATINOCYTES_Human3.40805480
8MYB_26560356_Chip-Seq_TH2_Human3.40655529
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32578049
10MYC_22102868_ChIP-Seq_BL_Human3.22677843
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.16082359
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11447069
13MAF_26560356_Chip-Seq_TH1_Human2.96597099
14UTX_26944678_Chip-Seq_JUKART_Human2.93220376
15MYB_26560356_Chip-Seq_TH1_Human2.85793058
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74138416
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.73731654
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63822981
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62310455
20SCL_19346495_ChIP-Seq_HPC-7_Human2.57976215
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56945602
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50887775
23TCF7_22412390_ChIP-Seq_EML_Mouse2.47509736
24MAF_26560356_Chip-Seq_TH2_Human2.45902329
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38100664
26VDR_21846776_ChIP-Seq_THP-1_Human2.35807865
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33760873
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.26383477
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.25328369
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.24064134
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23822029
32GATA3_27048872_Chip-Seq_THYMUS_Human2.23773199
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.23648915
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.22685414
35IRF8_21731497_ChIP-ChIP_J774_Mouse2.18383754
36KDM2B_26808549_Chip-Seq_DND41_Human2.16890396
37SPI1_23547873_ChIP-Seq_NB4_Human2.15815800
38NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.11517215
39STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10127146
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08651883
41VDR_24763502_ChIP-Seq_THP-1_Human2.08606093
42CTCF_20526341_ChIP-Seq_ESCs_Human2.07915660
43KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07704836
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06834081
45TP63_17297297_ChIP-ChIP_HaCaT_Human12.7498839
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99720367
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99543841
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.94267986
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93641459
50SPI1_23127762_ChIP-Seq_K562_Human1.91391567
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89797147
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.84537355
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82105199
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.77042850
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72109129
56E2F1_20622854_ChIP-Seq_HELA_Human1.70775171
57GATA3_26560356_Chip-Seq_TH2_Human1.68599417
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64992694
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.63685942
60TAF2_19829295_ChIP-Seq_ESCs_Human1.61466212
61EGR1_19032775_ChIP-ChIP_M12_Human1.59755442
62ERG_20517297_ChIP-Seq_VCAP_Human1.59550812
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58980466
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.56770740
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56552458
66P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.56063076
67CTCF_27219007_Chip-Seq_Bcells_Human1.55999853
68NANOG_20526341_ChIP-Seq_ESCs_Human1.53431626
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.53249432
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53242361
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52810555
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51948968
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49801937
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49434863
75AHR_22903824_ChIP-Seq_MCF-7_Human1.48988587
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44806139
77TP63_22573176_ChIP-Seq_HFKS_Human1.44215276
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43780699
79* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.42403728
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42321849
81* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.41832131
82AR_21572438_ChIP-Seq_LNCaP_Human1.40349053
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.40166055
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39768570
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39768570
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39684924
87CIITA_25753668_ChIP-Seq_RAJI_Human1.38985271
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.37079361
89RACK7_27058665_Chip-Seq_MCF-7_Human1.34581288
90P53_21459846_ChIP-Seq_SAOS-2_Human1.34296339
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33965041
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33677387
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.33640431
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.30965635
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30370262
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29135580
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26805056
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25852608
99BCL6_27268052_Chip-Seq_Bcells_Human1.25537071
100LXR_22292898_ChIP-Seq_THP-1_Human1.25451002
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.23066757
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.22607817
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22584346
104ATF3_27146783_Chip-Seq_COLON_Human1.20199335
105GATA1_19941826_ChIP-Seq_K562_Human1.20141087
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19736192
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19513979
108TP63_23658742_ChIP-Seq_EP156T_Human1.18026386
109PU_27001747_Chip-Seq_BMDM_Mouse1.17503307
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.16426090
111BCOR_27268052_Chip-Seq_Bcells_Human1.13777703
112EZH2_27304074_Chip-Seq_ESCs_Mouse1.13191528
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.12962699
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12898249
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12173259
116E2F1_17053090_ChIP-ChIP_MCF-7_Human1.11749263
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.11461191
118JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11243477
119ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11171841
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10575111
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10291702
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09290170
123TP53_18474530_ChIP-ChIP_U2OS_Human1.09182059
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.08825220
125EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07262931
126RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07262931
127RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06687907
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05682175
129CEBPB_22108803_ChIP-Seq_LS180_Human1.05488008
130P68_20966046_ChIP-Seq_HELA_Human1.05332811
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05111146
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03594020
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02868503
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.02072258
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01441028
136PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00604553
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00204578
138VDR_24787735_ChIP-Seq_THP-1_Human1.00172401
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99711960
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99636478
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.99566843
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99439324
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98999265
144RAC3_21632823_ChIP-Seq_H3396_Human0.98970054
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98785002
146SMC4_20622854_ChIP-Seq_HELA_Human0.98162684
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97553264
148ZNF263_19887448_ChIP-Seq_K562_Human0.97547775
149KLF5_25053715_ChIP-Seq_YYC3_Human0.97290791
150JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97222388
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96943436
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96879383
153CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96659659
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.96401945
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96129306
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95058343
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94877259
158EED_16625203_ChIP-ChIP_MESCs_Mouse0.94818900
159NCOR1_26117541_ChIP-Seq_K562_Human0.94374092
160RXR_22108803_ChIP-Seq_LS180_Human0.94280490
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93759007
162* PHF8_20622854_ChIP-Seq_HELA_Human0.93369470
163GATA2_19941826_ChIP-Seq_K562_Human0.91792807
164GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91387369
165TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91247390
166SOX2_21211035_ChIP-Seq_LN229_Human0.90121728
167GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89494338
168RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89347905
169SA1_27219007_Chip-Seq_ERYTHROID_Human0.89251981
170PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88979365
171PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88809493
172TCF4_18268006_ChIP-ChIP_LS174T_Human0.88358098
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.88313022
174SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88174847
175* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87740204
176CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87679477
177PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86669867
178PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86223988
179CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85478056
180MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85423313
181CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85382175
182FOXH1_21741376_ChIP-Seq_ESCs_Human0.84820521
183GATA6_21074721_ChIP-Seq_CACO-2_Human0.84327111
184* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83707290
185SOX2_20726797_ChIP-Seq_SW620_Human0.82378313
186GATA4_25053715_ChIP-Seq_YYC3_Human0.81606786
187CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80382375
188Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80311254
189* ELF1_20517297_ChIP-Seq_JURKAT_Human0.78916219
190SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78662294
191FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77661215
192SMAD_19615063_ChIP-ChIP_OVARY_Human0.76110990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology8.07995885
2MP0002098_abnormal_vibrissa_morphology6.78743570
3MP0000647_abnormal_sebaceous_gland6.17611986
4MP0002796_impaired_skin_barrier5.68504574
5MP0005275_abnormal_skin_tensile5.08153514
6MP0010234_abnormal_vibrissa_follicle4.95466819
7MP0000383_abnormal_hair_follicle4.87900578
8MP0010678_abnormal_skin_adnexa4.29435010
9MP0000377_abnormal_hair_follicle3.97205060
10MP0002396_abnormal_hematopoietic_system3.93339387
11MP0000427_abnormal_hair_cycle3.66430815
12MP0005501_abnormal_skin_physiology3.52373345
13MP0003705_abnormal_hypodermis_morpholog3.47501497
14MP0003436_decreased_susceptibility_to3.46113246
15MP0003300_gastrointestinal_ulcer3.36923999
16MP0003724_increased_susceptibility_to3.29305179
17MP0001800_abnormal_humoral_immune3.05463699
18MP0002254_reproductive_system_inflammat2.96421537
19MP0000685_abnormal_immune_system2.90018735
20MP0001835_abnormal_antigen_presentation2.88292115
21MP0005671_abnormal_response_to2.70693629
22MP0001216_abnormal_epidermal_layer2.66084662
23MP0005000_abnormal_immune_tolerance2.63685447
24MP0002420_abnormal_adaptive_immunity2.54933999
25MP0005387_immune_system_phenotype2.52440675
26MP0001790_abnormal_immune_system2.52440675
27MP0001819_abnormal_immune_cell2.52276807
28MP0004381_abnormal_hair_follicle2.50404378
29MP0000703_abnormal_thymus_morphology2.46547455
30MP0002723_abnormal_immune_serum2.46239277
31MP0009278_abnormal_bone_marrow2.34665150
32MP0002398_abnormal_bone_marrow2.33798342
33MP0002452_abnormal_antigen_presenting2.29826882
34MP0010771_integument_phenotype2.27653485
35MP0000367_abnormal_coat/_hair2.26874801
36MP0009333_abnormal_splenocyte_physiolog2.25196686
37MP0005025_abnormal_response_to2.23878757
38MP0001243_abnormal_dermal_layer2.21707064
39MP0002419_abnormal_innate_immunity2.20590906
40MP0003453_abnormal_keratinocyte_physiol2.13485745
41MP0002060_abnormal_skin_morphology2.12336534
42MP0003303_peritoneal_inflammation2.11608474
43MP0004947_skin_inflammation2.07554200
44MP0000716_abnormal_immune_system2.05684459
45MP0000467_abnormal_esophagus_morphology2.04606257
46MP0008260_abnormal_autophagy1.99875242
47MP0002234_abnormal_pharynx_morphology1.94303911
48MP0002722_abnormal_immune_system1.89039450
49MP0003866_abnormal_defecation1.87437836
50MP0002405_respiratory_system_inflammati1.87112222
51MP0000689_abnormal_spleen_morphology1.83697168
52MP0005464_abnormal_platelet_physiology1.74508030
53MP0010155_abnormal_intestine_physiology1.73903421
54MP0002148_abnormal_hypersensitivity_rea1.70498370
55MP0000762_abnormal_tongue_morphology1.68114778
56MP0002429_abnormal_blood_cell1.61359248
57MP0005409_darkened_coat_color1.59375224
58MP0009053_abnormal_anal_canal1.58074611
59MP0006082_CNS_inflammation1.50113909
60MP0009785_altered_susceptibility_to1.47865430
61MP0001533_abnormal_skeleton_physiology1.47627728
62MP0001873_stomach_inflammation1.45099551
63MP0009931_abnormal_skin_appearance1.41657643
64MP0003828_pulmonary_edema1.37006270
65MP0002822_catalepsy1.33057920
66MP0001845_abnormal_inflammatory_respons1.30859125
67MP0000015_abnormal_ear_pigmentation1.29150728
68MP0003566_abnormal_cell_adhesion1.29094501
69MP0002166_altered_tumor_susceptibility1.26955462
70MP0001545_abnormal_hematopoietic_system1.25729029
71MP0005397_hematopoietic_system_phenotyp1.25729029
72MP0001853_heart_inflammation1.20682539
73MP0000858_altered_metastatic_potential1.16857240
74MP0005310_abnormal_salivary_gland1.15974117
75MP0003941_abnormal_skin_development1.08338972
76MP0009764_decreased_sensitivity_to1.05641861
77MP0001346_abnormal_lacrimal_gland1.05458085
78MP0002006_tumorigenesis1.03560295
79MP0004808_abnormal_hematopoietic_stem1.03488058
80MP0002998_abnormal_bone_remodeling0.99650999
81MP0002132_abnormal_respiratory_system0.99107970
82MP0002933_joint_inflammation0.96859638
83MP0001191_abnormal_skin_condition0.93356924
84MP0001661_extended_life_span0.92987302
85MP0003172_abnormal_lysosome_physiology0.92823508
86MP0002019_abnormal_tumor_incidence0.92458869
87MP0000490_abnormal_crypts_of0.91887442
88MP0004264_abnormal_extraembryonic_tissu0.91420623
89MP0008469_abnormal_protein_level0.91306403
90MP0004885_abnormal_endolymph0.90946716
91MP0004130_abnormal_muscle_cell0.87651287
92MP0001851_eye_inflammation0.87013054
93MP0010030_abnormal_orbit_morphology0.82166155
94MP0000566_synostosis0.82131612
95MP0002095_abnormal_skin_pigmentation0.81778699
96MP0008057_abnormal_DNA_replication0.81259166
97MP0004883_abnormal_blood_vessel0.80896876
98MP0002282_abnormal_trachea_morphology0.77637577
99MP0001340_abnormal_eyelid_morphology0.77511417
100MP0002277_abnormal_respiratory_mucosa0.76494058
101MP0004185_abnormal_adipocyte_glucose0.76315264
102MP0008961_abnormal_basal_metabolism0.73121861
103MP0005166_decreased_susceptibility_to0.70735352
104MP0003755_abnormal_palate_morphology0.70265450
105MP0005535_abnormal_body_temperature0.69778654
106MP0003183_abnormal_peptide_metabolism0.68519818
107MP0001986_abnormal_taste_sensitivity0.67563893
108MP0004510_myositis0.64074279
109MP0001663_abnormal_digestive_system0.62025575
110MP0008438_abnormal_cutaneous_collagen0.60702055
111MP0003315_abnormal_perineum_morphology0.60192975
112MP0001727_abnormal_embryo_implantation0.57931094
113MP0009115_abnormal_fat_cell0.56995136
114MP0005248_abnormal_Harderian_gland0.56857927
115MP0008873_increased_physiological_sensi0.56575134
116MP0000627_abnormal_mammary_gland0.56477934
117MP0004484_altered_response_of0.55573924
118MP0003448_altered_tumor_morphology0.55499845
119MP0003045_fibrosis0.54038525
120MP0001849_ear_inflammation0.53073970
121MP0002249_abnormal_larynx_morphology0.53009308
122MP0003221_abnormal_cardiomyocyte_apopto0.52816738
123MP0000249_abnormal_blood_vessel0.52459897
124MP0003787_abnormal_imprinting0.51290610
125MP0002877_abnormal_melanocyte_morpholog0.50473474
126MP0003385_abnormal_body_wall0.48695302
127MP0009763_increased_sensitivity_to0.48115984
128MP0003795_abnormal_bone_structure0.45590661
129MP0001188_hyperpigmentation0.45020342
130MP0008874_decreased_physiological_sensi0.44521885
131MP0002111_abnormal_tail_morphology0.44517688
132MP0008004_abnormal_stomach_pH0.43425697
133MP0008877_abnormal_DNA_methylation0.42972357
134MP0002970_abnormal_white_adipose0.40653661
135MP0001784_abnormal_fluid_regulation0.40614044
136MP0005451_abnormal_body_composition0.36780693
137MP0009384_cardiac_valve_regurgitation0.36348102
138MP0005023_abnormal_wound_healing0.35471033
139MP0002177_abnormal_outer_ear0.34245866
140MP0003950_abnormal_plasma_membrane0.33973509
141MP0002697_abnormal_eye_size0.33111952
142MP0000516_abnormal_urinary_system0.28705531
143MP0005367_renal/urinary_system_phenotyp0.28705531
144MP0000537_abnormal_urethra_morphology0.27976058
145MP0006054_spinal_hemorrhage0.27694135
146MP0000678_abnormal_parathyroid_gland0.27442634
147MP0005075_abnormal_melanosome_morpholog0.25475619
148MP0004272_abnormal_basement_membrane0.25212096
149MP0000432_abnormal_head_morphology0.24335485
150MP0003935_abnormal_craniofacial_develop0.24035358
151MP0002837_dystrophic_cardiac_calcinosis0.22846020
152MP0000462_abnormal_digestive_system0.22652691
153MP0000751_myopathy0.21261202
154MP0002233_abnormal_nose_morphology0.19513888
155MP0000465_gastrointestinal_hemorrhage0.19010122
156MP0003191_abnormal_cellular_cholesterol0.18452324
157MP0005076_abnormal_cell_differentiation0.17438891
158MP0004742_abnormal_vestibular_system0.15418053
159MP0008569_lethality_at_weaning0.14723910
160MP0003329_amyloid_beta_deposits0.13988668
161MP0008770_decreased_survivor_rate0.12168527
162MP0010352_gastrointestinal_tract_polyps0.12150065
163MP0004858_abnormal_nervous_system0.12075473
164MP0000013_abnormal_adipose_tissue0.11792690
165MP0005193_abnormal_anterior_eye0.11181638
166MP0002653_abnormal_ependyma_morphology0.10881792
167MP0002735_abnormal_chemical_nociception0.10655227
168MP0003937_abnormal_limbs/digits/tail_de0.10362584
169MP0002109_abnormal_limb_morphology0.10234070
170MP0004859_abnormal_synaptic_plasticity0.09842770
171MP0001286_abnormal_eye_development0.09734791
172MP0000538_abnormal_urinary_bladder0.08903110
173MP0001270_distended_abdomen0.08896881
174MP0005508_abnormal_skeleton_morphology0.08788034
175MP0003119_abnormal_digestive_system0.08763024
176MP0001879_abnormal_lymphatic_vessel0.08168634
177MP0002009_preneoplasia0.07752027
178MP0002116_abnormal_craniofacial_bone0.07413175
179MP0003763_abnormal_thymus_physiology0.06965114
180MP0004036_abnormal_muscle_relaxation0.05919563
181MP0000049_abnormal_middle_ear0.05853321

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.85109243
2Brittle hair (HP:0002299)9.46828552
3Nail dystrophy (HP:0008404)6.95946819
4Abnormality of nail color (HP:0100643)6.69756698
5Eczematoid dermatitis (HP:0000976)6.17902823
6Abnormal hair laboratory examination (HP:0003328)6.17816611
7Fragile nails (HP:0001808)5.89429068
8Stomatitis (HP:0010280)5.76153072
9Follicular hyperkeratosis (HP:0007502)5.38557667
10Elevated erythrocyte sedimentation rate (HP:0003565)5.26850525
11Abnormal delayed hypersensitivity skin test (HP:0002963)5.22394009
12Alopecia of scalp (HP:0002293)5.11649590
13Pustule (HP:0200039)4.94059817
14Fine hair (HP:0002213)4.92210640
15Palmoplantar hyperkeratosis (HP:0000972)4.92020749
16Myositis (HP:0100614)4.92011415
17Onycholysis (HP:0001806)4.78936517
18Panhypogammaglobulinemia (HP:0003139)4.72924689
19T lymphocytopenia (HP:0005403)4.72457345
20Thick nail (HP:0001805)4.66228532
21Palmar hyperkeratosis (HP:0010765)4.61838857
22Plantar hyperkeratosis (HP:0007556)4.54405301
23Abnormality of T cell number (HP:0011839)4.35530388
24Right ventricular cardiomyopathy (HP:0011663)4.26437194
25Increased IgE level (HP:0003212)4.19641967
26Recurrent bacterial skin infections (HP:0005406)4.15681298
27Recurrent abscess formation (HP:0002722)3.99677803
28Recurrent fungal infections (HP:0002841)3.91991744
29Milia (HP:0001056)3.90872504
30Prolonged bleeding time (HP:0003010)3.80786896
31Sparse eyelashes (HP:0000653)3.75938669
32Granulocytopenia (HP:0001913)3.68930335
33Abnormality of T cells (HP:0002843)3.67475730
34Oral leukoplakia (HP:0002745)3.64868051
35Erythema (HP:0010783)3.56185542
36Meningitis (HP:0001287)3.46801814
37Mediastinal lymphadenopathy (HP:0100721)3.31553385
38Recurrent viral infections (HP:0004429)3.27904229
39Recurrent skin infections (HP:0001581)3.27444207
40Stomach cancer (HP:0012126)3.26313168
41Orchitis (HP:0100796)3.23147227
42Amelogenesis imperfecta (HP:0000705)3.22527950
43Abnormality of the frontal sinuses (HP:0002687)3.21726264
44Verrucae (HP:0200043)3.21133265
45Papilloma (HP:0012740)3.21133265
46Papilledema (HP:0001085)3.19940817
47Spontaneous hematomas (HP:0007420)3.19001281
48Retrobulbar optic neuritis (HP:0100654)3.17895729
49Optic neuritis (HP:0100653)3.17895729
50Encephalitis (HP:0002383)3.12347220
51Chronic mucocutaneous candidiasis (HP:0002728)3.10932728
52Recurrent cutaneous fungal infections (HP:0011370)3.10932728
53Eosinophilia (HP:0001880)3.08218207
54Leukocytosis (HP:0001974)3.05597201
55Abnormality of macrophages (HP:0004311)3.01205805
56Severe combined immunodeficiency (HP:0004430)3.01073821
57IgG deficiency (HP:0004315)3.00451057
58Parakeratosis (HP:0001036)2.97550449
59Abnormality of T cell physiology (HP:0011840)2.97024947
60Congenital, generalized hypertrichosis (HP:0004540)2.92749230
61IgM deficiency (HP:0002850)2.89328421
62Gastrointestinal infarctions (HP:0005244)2.87087642
63Increased IgM level (HP:0003496)2.86912408
64Hypergammaglobulinemia (HP:0010702)2.85244126
65Basal cell carcinoma (HP:0002671)2.84184809
66Curly hair (HP:0002212)2.81313405
67Inflammation of the large intestine (HP:0002037)2.79663726
68Vasculitis (HP:0002633)2.78346390
69Lymphopenia (HP:0001888)2.77991847
70Ridged nail (HP:0001807)2.77470712
71Erythroderma (HP:0001019)2.77248520
72Abnormality of eosinophils (HP:0001879)2.75940541
73Gastrointestinal inflammation (HP:0004386)2.75922861
74Aplasia cutis congenita (HP:0001057)2.75462611
75Recurrent gram-negative bacterial infections (HP:0005420)2.67772940
76Hypochromic anemia (HP:0001931)2.64702256
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.58210152
78Obstructive lung disease (HP:0006536)2.55646916
79Chronic obstructive pulmonary disease (HP:0006510)2.55646916
80Hypochromic microcytic anemia (HP:0004840)2.53883834
81Subacute progressive viral hepatitis (HP:0006572)2.53203918
82Intention tremor (HP:0002080)2.51962512
83Abnormal blistering of the skin (HP:0008066)2.51474475
84Urticaria (HP:0001025)2.48860169
85Cellulitis (HP:0100658)2.47041032
86Chest pain (HP:0100749)2.46476826
87Agammaglobulinemia (HP:0004432)2.44186628
88Abnormality of the fingertips (HP:0001211)2.43339997
89Neck muscle weakness (HP:0000467)2.43171315
90Combined immunodeficiency (HP:0005387)2.42656984
91Natal tooth (HP:0000695)2.42163644
92Dry hair (HP:0011359)2.39837823
93Epistaxis (HP:0000421)2.39183294
94Viral hepatitis (HP:0006562)2.39174013
95Torticollis (HP:0000473)2.39024892
96Autoimmune hemolytic anemia (HP:0001890)2.36079442
97Congenital ichthyosiform erythroderma (HP:0007431)2.32881003
98Advanced eruption of teeth (HP:0006288)2.29959994
99Abnormality of the parietal bone (HP:0002696)2.27674004
100Seborrheic dermatitis (HP:0001051)2.27548473
101Gingivitis (HP:0000230)2.25724044
102Absent eyelashes (HP:0000561)2.20113062
103Facial diplegia (HP:0001349)2.19178163
104Colitis (HP:0002583)2.16215016
105Episodic fever (HP:0001954)2.12945468
106Syringomyelia (HP:0003396)2.10994602
107Spinal cord lesions (HP:0100561)2.10994602
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10084954
109Pulmonary infiltrates (HP:0002113)2.09231417
110Abnormality of the periventricular white matter (HP:0002518)2.08054411
111Recurrent bronchitis (HP:0002837)2.07412565
112Corneal erosion (HP:0200020)2.05548325
113Hypohidrosis (HP:0000966)2.05190280
114Slow saccadic eye movements (HP:0000514)2.04342750
115Craniofacial dystonia (HP:0012179)2.04302962
116Pulmonary embolism (HP:0002204)2.03689952
117Coarse hair (HP:0002208)2.01864132
118Skin ulcer (HP:0200042)2.01417511
119Hypotrichosis (HP:0001006)13.7997898
120Woolly hair (HP:0002224)11.1890630
121Abnormality of hair growth rate (HP:0011363)10.2557186
122Slow-growing hair (HP:0002217)10.2557186
123Palmoplantar keratoderma (HP:0000982)1.99494056
124Joint swelling (HP:0001386)1.97680785
125Supernumerary ribs (HP:0005815)1.96262567
126Abnormality of the columella (HP:0009929)1.96137406
127Lymphoma (HP:0002665)1.95431382
128Ventricular tachycardia (HP:0004756)1.93192537
129Concave nail (HP:0001598)1.92763055
130Gingival bleeding (HP:0000225)1.91874282
131Sepsis (HP:0100806)1.91210051
132Focal dystonia (HP:0004373)1.90162783
133Hemoptysis (HP:0002105)1.90122257
134Gangrene (HP:0100758)1.89968392
135Microcytic anemia (HP:0001935)1.89828265
136Abnormality of permanent molar morphology (HP:0011071)1.89791406
137Abnormality of the dental root (HP:0006486)1.89791406
138Taurodontia (HP:0000679)1.89791406
139Alveolar cell carcinoma (HP:0006519)1.85375951
140Abnormality of molar morphology (HP:0011070)1.85361911
141Abnormality of molar (HP:0011077)1.85361911
142Ventricular fibrillation (HP:0001663)1.85213533
143Lip pit (HP:0100267)1.83992447
144Neoplasm of the tracheobronchial system (HP:0100552)1.83248756
145Pruritus (HP:0000989)1.82074536
146Abnormality of dental color (HP:0011073)1.81641252
147Recurrent corneal erosions (HP:0000495)1.80378736
148Abnormality of the pupil (HP:0000615)1.80332897
149Difficulty walking (HP:0002355)1.73689760
150Conjunctival hamartoma (HP:0100780)1.72850599
151Blepharitis (HP:0000498)1.72728981
152Fatigable weakness (HP:0003473)1.67302689
153Abnormality of the neuromuscular junction (HP:0003398)1.67302689
154Atrophic scars (HP:0001075)1.65054457
155Widely patent fontanelles and sutures (HP:0004492)1.64927247
156Abnormality of the dental pulp (HP:0006479)1.64403078
157Amniotic constriction ring (HP:0009775)1.61309239
158Abnormality of placental membranes (HP:0011409)1.61309239
159Autoamputation (HP:0001218)1.56741306
160Carious teeth (HP:0000670)1.53404024
161Anonychia (HP:0001798)1.46675619
162Acanthosis nigricans (HP:0000956)1.45713529
163Abnormality of the aortic arch (HP:0012303)1.44442115
164Hyporeflexia of lower limbs (HP:0002600)1.44116467
165Heterogeneous (HP:0001425)1.42452347
166Sparse scalp hair (HP:0002209)1.40782644
167Widely spaced teeth (HP:0000687)1.39346945
168Sudden death (HP:0001699)1.38886882
169Type 1 muscle fiber predominance (HP:0003803)1.38652710
170Abnormality of the fingernails (HP:0001231)1.38070295
171Unilateral renal agenesis (HP:0000122)1.37698398
172Laryngomalacia (HP:0001601)1.34320172
173Keratoconjunctivitis sicca (HP:0001097)1.32838281
174Fragile skin (HP:0001030)1.32170670
175Achilles tendon contracture (HP:0001771)1.31581317
176Craniofacial hyperostosis (HP:0004493)1.31225175
177Round ear (HP:0100830)1.29830396
178Increased connective tissue (HP:0009025)1.25164669
179Ectropion (HP:0000656)1.24290384
180Hypoplastic labia majora (HP:0000059)1.22985298
181Abnormality of the Achilles tendon (HP:0005109)1.21168015
182Down-sloping shoulders (HP:0200021)1.20799850
183Corneal dystrophy (HP:0001131)1.20733018
184Neonatal onset (HP:0003623)1.20368297
185Selective tooth agenesis (HP:0001592)1.19785748
186Distal lower limb muscle weakness (HP:0009053)1.18237918
187Keratoconjunctivitis (HP:0001096)1.18179447
188Hyperhidrosis (HP:0000975)1.15470444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.99377256
2MAP3K64.45124002
3FER4.04263445
4EPHA23.76146189
5RIPK43.64531091
6MAPKAPK33.59712911
7TXK3.58519311
8EPHB23.43775414
9PRPF4B3.41825499
10TAOK13.31535524
11NME13.04258698
12ERN12.83376162
13LATS12.80323968
14JAK32.68101891
15MAP3K112.44670039
16MAP3K32.41252966
17ZAP702.35847314
18TAOK32.26391670
19GRK62.24084387
20NLK2.19310149
21ITK2.15988024
22LATS22.15769936
23MAP3K122.04879172
24MAP3K21.97506959
25TRIB31.92756999
26FES1.88353968
27SIK31.87898101
28CSK1.82418807
29MAP3K91.81247498
30MAP2K41.77193564
31BTK1.77106508
32TYK21.76852413
33BCR1.73315322
34MAP3K141.65407694
35SYK1.65021073
36DYRK31.64810760
37EEF2K1.64685149
38FGFR21.60643463
39MAP3K131.56189738
40PIK3CG1.53953013
41IRAK41.51705322
42ERBB41.49424421
43TNK21.47057867
44MAP3K11.46759574
45HCK1.43721771
46LCK1.40378413
47RPS6KB21.38591772
48TTN1.36325802
49CDK121.33620660
50SIK11.32186441
51IKBKE1.30734838
52MARK31.27922455
53ZAK1.27016624
54SIK21.23563614
55CAMKK21.23467215
56STK38L1.20679506
57MAP2K61.17130541
58KSR21.16745026
59FGFR11.14242162
60MAPK71.10582703
61PASK1.09921406
62MAP3K71.08519399
63TEC1.05815836
64HIPK21.05011937
65RIPK11.04138858
66MST1R1.02983974
67AKT31.02005294
68LYN0.99845038
69CAMKK10.98466268
70EPHB10.97895689
71STK380.97376953
72NTRK20.97305636
73PIM10.95587719
74DDR20.95323892
75BMX0.94866670
76FGFR30.94533307
77CDK60.94105098
78STK100.88847051
79BRD40.85883040
80SMG10.82826037
81MAPKAPK20.81537126
82FGFR40.80250141
83NEK10.79805560
84JAK20.78971933
85NTRK30.78084336
86TBK10.77820483
87PDGFRA0.76450547
88DYRK1B0.73872521
89BMPR20.73774322
90CDK40.73428746
91MAP3K50.70606827
92PRKCQ0.69523754
93IKBKB0.69235993
94MAP2K10.68944207
95KIT0.67923839
96IRAK10.66431521
97SGK20.64861921
98PAK60.63430465
99LIMK10.61450234
100TRPM70.59844543
101FGR0.59210892
102PRKD10.58351538
103PRKCI0.58144643
104MAP3K100.57819546
105PTK60.56758704
106OBSCN0.56709542
107MAPK110.55718072
108PRKCH0.55251403
109PDK10.54778176
110CDK190.54466237
111MELK0.54425963
112PTK20.50836362
113PDGFRB0.48547234
114PAK40.48212140
115MINK10.47688708
116TESK10.47272561
117MST40.47014659
118RPS6KA40.46991915
119YES10.46119115
120TYRO30.45710299
121RET0.44638299
122DMPK0.43922429
123CSF1R0.43886088
124RPS6KA10.41979485
125CSNK1E0.41009475
126FYN0.40403070
127PRKACA0.40341317
128PAK30.39856120
129ERBB20.39656810
130NTRK10.39081734
131ERBB30.38646607
132SGK4940.38422059
133SGK2230.38422059
134KSR10.37707613
135MET0.36803927
136PKN20.36240351
137CAMK40.35615296
138CDC42BPA0.35209756
139STK110.35054303
140EPHA30.34353059
141SGK10.33584714
142MARK20.33516797
143MAPK30.32965102
144MAP2K30.32597804
145SGK30.32463765
146BLK0.32168738
147GSK3A0.31708527
148KDR0.31093349
149EPHA40.30635305
150ALK0.29728426
151CSNK1A10.28843262
152MAP2K20.28764904
153CSNK1A1L0.28445793
154ICK0.28068943
155MAPK80.27629687
156PRKACG0.27605755
157CSNK1D0.26651560
158PIM20.26410084
159CDK50.26095409
160MAPK120.25308235
161PKN10.23679553
162JAK10.23371930
163PHKG10.22307727
164PHKG20.22307727
165MAPK90.21685163

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.23947105
2Linoleic acid metabolism_Homo sapiens_hsa005914.18409353
3Primary immunodeficiency_Homo sapiens_hsa053403.39826616
4Basal cell carcinoma_Homo sapiens_hsa052173.07559961
5T cell receptor signaling pathway_Homo sapiens_hsa046602.82691529
6Fatty acid elongation_Homo sapiens_hsa000622.81724928
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.65677669
8Fat digestion and absorption_Homo sapiens_hsa049752.41485275
9Osteoclast differentiation_Homo sapiens_hsa043802.37656364
10Graft-versus-host disease_Homo sapiens_hsa053322.32618807
11Ether lipid metabolism_Homo sapiens_hsa005652.31062943
12B cell receptor signaling pathway_Homo sapiens_hsa046622.30691890
13Hedgehog signaling pathway_Homo sapiens_hsa043402.08834758
14Allograft rejection_Homo sapiens_hsa053302.03187007
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.99446652
16Autoimmune thyroid disease_Homo sapiens_hsa053201.95423059
17Measles_Homo sapiens_hsa051621.95090330
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94705813
19Leishmaniasis_Homo sapiens_hsa051401.92877048
20Melanogenesis_Homo sapiens_hsa049161.80624716
21Hematopoietic cell lineage_Homo sapiens_hsa046401.75514220
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.72592095
23Axon guidance_Homo sapiens_hsa043601.70271835
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.67083406
25Collecting duct acid secretion_Homo sapiens_hsa049661.66765643
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64915986
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58048932
28Hippo signaling pathway_Homo sapiens_hsa043901.57900573
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54490500
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53713624
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49419924
32Synaptic vesicle cycle_Homo sapiens_hsa047211.47968427
33Staphylococcus aureus infection_Homo sapiens_hsa051501.47000323
34Viral myocarditis_Homo sapiens_hsa054161.46961203
35Pancreatic cancer_Homo sapiens_hsa052121.44451980
36Tuberculosis_Homo sapiens_hsa051521.43496767
37Arachidonic acid metabolism_Homo sapiens_hsa005901.42274491
38Antigen processing and presentation_Homo sapiens_hsa046121.41944047
39VEGF signaling pathway_Homo sapiens_hsa043701.40083910
40Chemokine signaling pathway_Homo sapiens_hsa040621.39340935
41Chronic myeloid leukemia_Homo sapiens_hsa052201.39335760
42Herpes simplex infection_Homo sapiens_hsa051681.38621316
43Glioma_Homo sapiens_hsa052141.37650644
44Phenylalanine metabolism_Homo sapiens_hsa003601.37188128
45Colorectal cancer_Homo sapiens_hsa052101.37152178
46Type I diabetes mellitus_Homo sapiens_hsa049401.36808801
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35343758
48Hepatitis B_Homo sapiens_hsa051611.32118427
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31917320
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28751425
51Tight junction_Homo sapiens_hsa045301.28155431
52GnRH signaling pathway_Homo sapiens_hsa049121.27277310
53Butanoate metabolism_Homo sapiens_hsa006501.25093561
54Bladder cancer_Homo sapiens_hsa052191.24505359
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24046765
56Proteoglycans in cancer_Homo sapiens_hsa052051.23922963
57Thyroid cancer_Homo sapiens_hsa052161.23479259
58Dorso-ventral axis formation_Homo sapiens_hsa043201.23154535
59Influenza A_Homo sapiens_hsa051641.22533416
60Toxoplasmosis_Homo sapiens_hsa051451.21218187
61Regulation of autophagy_Homo sapiens_hsa041401.19361095
62Acute myeloid leukemia_Homo sapiens_hsa052211.16123537
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.14070557
64Platelet activation_Homo sapiens_hsa046111.13524316
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.13072810
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11091855
67Malaria_Homo sapiens_hsa051441.10961491
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10648940
69Vibrio cholerae infection_Homo sapiens_hsa051101.10367812
70TNF signaling pathway_Homo sapiens_hsa046681.09769786
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09645225
72ECM-receptor interaction_Homo sapiens_hsa045121.08683588
73Wnt signaling pathway_Homo sapiens_hsa043101.08489110
74Long-term potentiation_Homo sapiens_hsa047201.08308034
75mTOR signaling pathway_Homo sapiens_hsa041501.06831662
76Endometrial cancer_Homo sapiens_hsa052131.06472847
77beta-Alanine metabolism_Homo sapiens_hsa004101.04435801
78Choline metabolism in cancer_Homo sapiens_hsa052311.04271547
79Selenocompound metabolism_Homo sapiens_hsa004501.02564487
80HTLV-I infection_Homo sapiens_hsa051661.00416756
81Apoptosis_Homo sapiens_hsa042101.00242347
82Mineral absorption_Homo sapiens_hsa049780.99384333
83Estrogen signaling pathway_Homo sapiens_hsa049150.98236512
84FoxO signaling pathway_Homo sapiens_hsa040680.97519193
85Long-term depression_Homo sapiens_hsa047300.97193136
86Adherens junction_Homo sapiens_hsa045200.94762937
87Inositol phosphate metabolism_Homo sapiens_hsa005620.93256293
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93226512
89Epstein-Barr virus infection_Homo sapiens_hsa051690.88121748
90African trypanosomiasis_Homo sapiens_hsa051430.87493942
91Ras signaling pathway_Homo sapiens_hsa040140.87213561
92Pancreatic secretion_Homo sapiens_hsa049720.84487846
93Non-small cell lung cancer_Homo sapiens_hsa052230.83070947
94Caffeine metabolism_Homo sapiens_hsa002320.81742814
95Viral carcinogenesis_Homo sapiens_hsa052030.80135996
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80056699
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78872038
98Protein digestion and absorption_Homo sapiens_hsa049740.78681117
99Shigellosis_Homo sapiens_hsa051310.78539196
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76284409
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.76086929
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.74663085
103Histidine metabolism_Homo sapiens_hsa003400.74144716
104Asthma_Homo sapiens_hsa053100.72464096
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72376780
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72350733
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69289147
108Dopaminergic synapse_Homo sapiens_hsa047280.68978855
109ErbB signaling pathway_Homo sapiens_hsa040120.68881777
110Gap junction_Homo sapiens_hsa045400.66785458
111Oxytocin signaling pathway_Homo sapiens_hsa049210.66285395
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65004792
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64629451
114Endocytosis_Homo sapiens_hsa041440.64400582
115Tyrosine metabolism_Homo sapiens_hsa003500.64181000
116TGF-beta signaling pathway_Homo sapiens_hsa043500.63725652
117Other glycan degradation_Homo sapiens_hsa005110.62733793
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62192827
119Rap1 signaling pathway_Homo sapiens_hsa040150.62054487
120Amoebiasis_Homo sapiens_hsa051460.61721775
121PPAR signaling pathway_Homo sapiens_hsa033200.61135716
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60200132
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.59650093
124MicroRNAs in cancer_Homo sapiens_hsa052060.59327649
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59253365
126Gastric acid secretion_Homo sapiens_hsa049710.58885588
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58218514
128Pertussis_Homo sapiens_hsa051330.56953205
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55550846
130Hepatitis C_Homo sapiens_hsa051600.55277117
131Melanoma_Homo sapiens_hsa052180.55032321
132Circadian entrainment_Homo sapiens_hsa047130.54519647
133Serotonergic synapse_Homo sapiens_hsa047260.54328631
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.53879296
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53622127
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52098549
137Focal adhesion_Homo sapiens_hsa045100.51520479
138Steroid biosynthesis_Homo sapiens_hsa001000.50903311
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50834126
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50423364
141Renin secretion_Homo sapiens_hsa049240.50295247
142Prolactin signaling pathway_Homo sapiens_hsa049170.50114814
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48985352
144Insulin resistance_Homo sapiens_hsa049310.48870071
145Phototransduction_Homo sapiens_hsa047440.48703998
146Salivary secretion_Homo sapiens_hsa049700.48461874
147Type II diabetes mellitus_Homo sapiens_hsa049300.47738427
148Renal cell carcinoma_Homo sapiens_hsa052110.47679897
149GABAergic synapse_Homo sapiens_hsa047270.47542925
150Legionellosis_Homo sapiens_hsa051340.47510155
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.47171063
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.46900846
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.46629455
154Phagosome_Homo sapiens_hsa041450.45808320
155Olfactory transduction_Homo sapiens_hsa047400.45224098
156HIF-1 signaling pathway_Homo sapiens_hsa040660.44673739
157Cholinergic synapse_Homo sapiens_hsa047250.43056876
158Notch signaling pathway_Homo sapiens_hsa043300.42603120
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41844913
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40707963
161Insulin signaling pathway_Homo sapiens_hsa049100.40384226
162Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39678274
163Pathways in cancer_Homo sapiens_hsa052000.39187915
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38191919
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37603649
166Rheumatoid arthritis_Homo sapiens_hsa053230.37413835
167Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37078978
168MAPK signaling pathway_Homo sapiens_hsa040100.37006815
169Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36761083
170Prostate cancer_Homo sapiens_hsa052150.36461793

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