KRT74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.02710018
2adhesion of symbiont to host cell (GO:0044650)9.02710018
3keratinization (GO:0031424)8.54589839
4desmosome organization (GO:0002934)7.59024642
5intermediate filament organization (GO:0045109)7.33653596
6adhesion of symbiont to host (GO:0044406)7.24147916
7linoleic acid metabolic process (GO:0043651)6.63122492
8adult feeding behavior (GO:0008343)6.02350247
9peptide cross-linking (GO:0018149)5.61083580
10very long-chain fatty acid metabolic process (GO:0000038)5.36586780
11establishment of skin barrier (GO:0061436)5.29155149
12negative regulation of metanephros development (GO:0072217)5.27488249
13regulation of feeding behavior (GO:0060259)5.23556891
14positive regulation of male gonad development (GO:2000020)5.09197574
15citrulline biosynthetic process (GO:0019240)4.95796330
16epithelial cell fate commitment (GO:0072148)4.88858507
17cellular response to gonadotropin stimulus (GO:0071371)4.88590876
18fatty-acyl-CoA biosynthetic process (GO:0046949)4.80256986
19hair follicle morphogenesis (GO:0031069)4.71633753
20regulation of water loss via skin (GO:0033561)4.64037380
21auditory receptor cell stereocilium organization (GO:0060088)4.60661055
22thioester biosynthetic process (GO:0035384)4.58701934
23acyl-CoA biosynthetic process (GO:0071616)4.58701934
24keratinocyte differentiation (GO:0030216)4.47975595
25fatty acid elongation (GO:0030497)4.36431734
26regulation of male gonad development (GO:2000018)4.32376500
27cellular extravasation (GO:0045123)4.21226376
28epidermis development (GO:0008544)4.19810188
29* intermediate filament cytoskeleton organization (GO:0045104)4.13447762
30alpha-linolenic acid metabolic process (GO:0036109)4.05622565
31response to gonadotropin (GO:0034698)4.04828918
32* intermediate filament-based process (GO:0045103)3.93677927
33interferon-gamma secretion (GO:0072643)3.93655534
34keratinocyte proliferation (GO:0043616)3.90476702
35glomerulus development (GO:0032835)3.84955911
36fatty-acyl-CoA metabolic process (GO:0035337)3.74229004
37negative regulation of type 2 immune response (GO:0002829)3.74090268
38hair cycle process (GO:0022405)3.70249253
39molting cycle process (GO:0022404)3.70249253
40regulation of cardioblast differentiation (GO:0051890)3.63792564
41positive regulation of monocyte chemotaxis (GO:0090026)3.62462659
42retinol metabolic process (GO:0042572)3.61847025
43negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.48491981
44cellular response to interferon-beta (GO:0035458)3.47500643
45skeletal muscle organ development (GO:0060538)3.46714803
46mesenchymal to epithelial transition (GO:0060231)3.46672583
47metanephric mesenchyme development (GO:0072075)3.43211737
48diaphragm development (GO:0060539)3.42509423
49short-chain fatty acid metabolic process (GO:0046459)3.37660630
50regulation of cell proliferation involved in kidney development (GO:1901722)3.37565977
51regulation of bile acid biosynthetic process (GO:0070857)3.34690288
52epidermal cell differentiation (GO:0009913)3.33268138
53male genitalia development (GO:0030539)3.30971847
54bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30298733
55eating behavior (GO:0042755)3.29840460
56long-chain fatty acid biosynthetic process (GO:0042759)3.27293687
57regulation of female gonad development (GO:2000194)3.26591489
58regulation of phospholipase A2 activity (GO:0032429)3.18061183
59cellular response to nicotine (GO:0071316)3.17701526
60regulation of glomerulus development (GO:0090192)3.16298331
61hemidesmosome assembly (GO:0031581)3.13604086
62negative regulation of kidney development (GO:0090185)3.12717800
63nuclear envelope reassembly (GO:0031468)3.10340147
64mitotic nuclear envelope reassembly (GO:0007084)3.10340147
65intestinal epithelial cell development (GO:0060576)3.09657687
66cellular response to interferon-alpha (GO:0035457)3.09352374
67positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.08925795
68regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.08925795
69muscle cell fate commitment (GO:0042693)3.07423958
70atrioventricular valve morphogenesis (GO:0003181)3.06049858
71cell wall macromolecule catabolic process (GO:0016998)3.04347403
72cell wall macromolecule metabolic process (GO:0044036)3.04347403
73epithelium development (GO:0060429)3.01143412
74primary alcohol metabolic process (GO:0034308)2.99604720
75regulation of cell maturation (GO:1903429)2.96144471
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.95493960
77kidney mesenchyme development (GO:0072074)2.95350558
78tooth mineralization (GO:0034505)2.94126983
79positive regulation of chemokine secretion (GO:0090197)2.91097916
80response to interleukin-6 (GO:0070741)2.88665362
81keratinocyte development (GO:0003334)2.87304038
82hair follicle development (GO:0001942)2.87196778
83negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83116488
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82866449
85positive regulation of actin filament depolymerization (GO:0030836)2.82512344
86neutrophil activation involved in immune response (GO:0002283)2.82435601
87sex determination (GO:0007530)2.82300648
88citrulline metabolic process (GO:0000052)2.82149973
89myotube differentiation (GO:0014902)2.80345746
90multicellular organismal water homeostasis (GO:0050891)2.80062456
91embryonic foregut morphogenesis (GO:0048617)2.79124293
92epithelial cell differentiation involved in kidney development (GO:0035850)2.77152347
93regulation of mesenchymal cell apoptotic process (GO:2001053)2.76032739
94interleukin-6-mediated signaling pathway (GO:0070102)2.75759400
95negative regulation of keratinocyte proliferation (GO:0010839)2.75595284
96phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.72431959
97glomerular basement membrane development (GO:0032836)2.71542844
98mesonephros development (GO:0001823)2.71246722
99ethanol metabolic process (GO:0006067)2.70502053
100cardiac muscle adaptation (GO:0014887)2.70179776
101cardiac muscle hypertrophy in response to stress (GO:0014898)2.70179776
102muscle hypertrophy in response to stress (GO:0003299)2.70179776
103regulation of monocyte chemotaxis (GO:0090025)2.69272150
104metanephric epithelium development (GO:0072207)2.67746903
105skin morphogenesis (GO:0043589)2.67483057
106biotin metabolic process (GO:0006768)2.67092888
107regulation of cytokine secretion involved in immune response (GO:0002739)2.66392003
108thioester metabolic process (GO:0035383)2.65096586
109acyl-CoA metabolic process (GO:0006637)2.65096586
110regulation of chemokine secretion (GO:0090196)2.63690417
111branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63672614
112protein-chromophore linkage (GO:0018298)2.62809444
113glucosamine-containing compound catabolic process (GO:1901072)2.62656884
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.62644536
115fusion of sperm to egg plasma membrane (GO:0007342)2.61107742
116lateral sprouting from an epithelium (GO:0060601)2.60835607
117histone H3-K4 trimethylation (GO:0080182)2.60589150
118lipoxygenase pathway (GO:0019372)2.55853008
119cellular response to interleukin-6 (GO:0071354)2.54723138
120positive regulation of keratinocyte differentiation (GO:0045618)2.52448977
121ear development (GO:0043583)2.52319317
122defense response to fungus (GO:0050832)2.49214595
123response to interferon-beta (GO:0035456)2.48584575
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48397246
125DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.47919261
126triglyceride biosynthetic process (GO:0019432)2.47027342
127inner ear receptor stereocilium organization (GO:0060122)2.46212735
128positive regulation of respiratory burst (GO:0060267)2.43975123
129endothelial cell chemotaxis (GO:0035767)2.41922615
130reproductive system development (GO:0061458)2.41899502
131SMAD protein signal transduction (GO:0060395)2.38551429
132long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.33201864
133regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.30549135
134bone trabecula formation (GO:0060346)2.28050628
135positive regulation of interleukin-1 beta secretion (GO:0050718)2.24932428
136amino sugar catabolic process (GO:0046348)2.24728834
137negative regulation of catenin import into nucleus (GO:0035414)2.24429027
138protein localization to cilium (GO:0061512)2.22233809
139positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.21294886
140peptidyl-arginine modification (GO:0018195)2.18422533
141cardiac right ventricle morphogenesis (GO:0003215)2.17679681
142positive regulation of cellular amine metabolic process (GO:0033240)2.17248712
143cytokine secretion (GO:0050663)2.15668652
144phosphatidylserine acyl-chain remodeling (GO:0036150)2.15593011
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.15437997
146negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.14583255
147regulation of vitamin D biosynthetic process (GO:0060556)2.13967512
148cranial suture morphogenesis (GO:0060363)2.12931877
149glutathione biosynthetic process (GO:0006750)2.11791625
150regulation of vitamin metabolic process (GO:0030656)2.10685024
151hydrogen peroxide biosynthetic process (GO:0050665)2.09154401
152phosphatidylinositol acyl-chain remodeling (GO:0036149)2.08060005
153positive regulation of interleukin-1 secretion (GO:0050716)2.08000972
154regulation of T cell chemotaxis (GO:0010819)2.07223636
155positive regulation of T cell chemotaxis (GO:0010820)2.07223636
156negative regulation of T cell mediated immunity (GO:0002710)2.06278535
157membrane assembly (GO:0071709)2.06168996
158positive regulation of interleukin-1 production (GO:0032732)2.06112610
159serine transport (GO:0032329)2.05136267
160response to interferon-alpha (GO:0035455)2.05029559
161photoperiodism (GO:0009648)2.04728243
162long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.04421588
163water homeostasis (GO:0030104)2.04366275
164muscle organ morphogenesis (GO:0048644)2.02763641
165amyloid precursor protein metabolic process (GO:0042982)2.02444146
166hair cycle (GO:0042633)19.0933311
167molting cycle (GO:0042303)19.0933311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.15169018
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.93422048
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.97885221
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.75437351
5EGR1_19032775_ChIP-ChIP_M12_Human2.46941170
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36157861
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29089278
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14291968
9TP63_17297297_ChIP-ChIP_HaCaT_Human11.5017049
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84050834
11ESR1_21235772_ChIP-Seq_MCF-7_Human1.79547118
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72256894
13IRF8_22096565_ChIP-ChIP_GC-B_Human1.68413841
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65541971
15CTCF_27219007_Chip-Seq_Bcells_Human1.62299765
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.60304449
17TP53_20018659_ChIP-ChIP_R1E_Mouse1.55775184
18CTCF_20526341_ChIP-Seq_ESCs_Human1.55233432
19BCOR_27268052_Chip-Seq_Bcells_Human1.54397548
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53614490
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53353457
22ZNF263_19887448_ChIP-Seq_K562_Human1.51712427
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49875120
24SOX2_20726797_ChIP-Seq_SW620_Human1.47938911
25* E2F1_20622854_ChIP-Seq_HELA_Human1.44037727
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43325873
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40161623
28ERG_20517297_ChIP-Seq_VCAP_Human1.38612048
29NANOG_20526341_ChIP-Seq_ESCs_Human1.36845606
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35393851
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31488794
32HTT_18923047_ChIP-ChIP_STHdh_Human1.30799096
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29021304
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27688557
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.27597112
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25784938
37RXR_22108803_ChIP-Seq_LS180_Human1.25778557
38TP53_18474530_ChIP-ChIP_U2OS_Human1.24414293
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23498464
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23498464
41CSB_26484114_Chip-Seq_FIBROBLAST_Human1.21776389
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18890224
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16511466
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16042088
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15425756
46AHR_22903824_ChIP-Seq_MCF-7_Human1.14665760
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.12295115
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.10863264
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10165710
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.09908103
51TP63_22573176_ChIP-Seq_HFKS_Human1.09815656
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08509553
53LXR_22292898_ChIP-Seq_THP-1_Human1.07943598
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07262140
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06619057
56STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05127912
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05051218
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.04948154
59RNF2_27304074_Chip-Seq_NSC_Mouse1.04377559
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.04374798
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03142174
62RACK7_27058665_Chip-Seq_MCF-7_Human1.03072438
63* P68_20966046_ChIP-Seq_HELA_Human1.02409888
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.02250481
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.01656853
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01392159
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00867468
68EZH2_27304074_Chip-Seq_ESCs_Mouse0.99914573
69RING1B_27294783_Chip-Seq_ESCs_Mouse0.99650283
70FOXH1_21741376_ChIP-Seq_ESCs_Human0.98350019
71STAT1_20625510_ChIP-Seq_HELA_Human0.98101392
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97538482
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96827447
74BCL6_27268052_Chip-Seq_Bcells_Human0.95450316
75BP1_19119308_ChIP-ChIP_Hs578T_Human0.94990817
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.94200086
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93585332
78GATA3_24758297_ChIP-Seq_MCF-7_Human0.93242871
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93167918
80* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93009018
81* FOXA1_25329375_ChIP-Seq_VCAP_Human0.93009018
82SA1_27219007_Chip-Seq_ERYTHROID_Human0.92692965
83MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.92534745
84UBF1/2_26484160_Chip-Seq_HMECs_Human0.91575587
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91416014
86* YY1_22570637_ChIP-Seq_MALME-3M_Human0.90263793
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89615055
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89615055
89CBX2_27304074_Chip-Seq_ESCs_Mouse0.89468743
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88586136
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88546015
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87623106
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86915491
94RUNX1_27514584_Chip-Seq_MCF-7_Human0.86798521
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86372462
96SA1_27219007_Chip-Seq_Bcells_Human0.85855517
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85699641
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84041437
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83548180
100TAF2_19829295_ChIP-Seq_ESCs_Human0.83232292
101RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82068369
102E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81936033
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81388005
104GATA4_25053715_ChIP-Seq_YYC3_Human0.81316885
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.80979653
106SPI1_20517297_ChIP-Seq_HL60_Human0.80893651
107* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80623204
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80025210
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79846178
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79692851
111NFYA_21822215_ChIP-Seq_K562_Human0.79456750
112OCT4_20526341_ChIP-Seq_ESCs_Human0.79007684
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.78957825
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78094869
115* TP63_23658742_ChIP-Seq_EP156T_Human0.77143170
116GATA3_21867929_ChIP-Seq_TH1_Mouse0.76321522
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76053127
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75958144
119* PHF8_20622854_ChIP-Seq_HELA_Human0.75456919
120SMAD4_21741376_ChIP-Seq_ESCs_Human0.75322204
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75221154
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.74049326
123P300_27268052_Chip-Seq_Bcells_Human0.73965959
124AR_21572438_ChIP-Seq_LNCaP_Human0.73522820
125TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73432073
126* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73322163
127* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73322163
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.73020990
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.72923829
130PHF8_20622853_ChIP-Seq_HELA_Human0.72567299
131GBX2_23144817_ChIP-Seq_PC3_Human0.72352440
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71742673
133GATA3_21878914_ChIP-Seq_MCF-7_Human0.71720102
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71618702
135KLF5_25053715_ChIP-Seq_YYC3_Human0.71508395
136KDM2B_26808549_Chip-Seq_K562_Human0.70581577
137NFYB_21822215_ChIP-Seq_K562_Human0.70250375
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69986540
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.69116686
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68993182
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68889809
142* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68701407
143ELK4_26923725_Chip-Seq_MESODERM_Mouse0.67345819
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63545972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.50672598
2MP0002098_abnormal_vibrissa_morphology5.76268516
3MP0002796_impaired_skin_barrier5.52669022
4MP0000383_abnormal_hair_follicle5.05373716
5MP0001661_extended_life_span4.98493777
6MP0000647_abnormal_sebaceous_gland4.90760901
7MP0010678_abnormal_skin_adnexa4.28780595
8MP0005275_abnormal_skin_tensile4.09535230
9MP0004381_abnormal_hair_follicle3.82814161
10MP0010234_abnormal_vibrissa_follicle3.41946021
11MP0000427_abnormal_hair_cycle3.21352125
12MP0005501_abnormal_skin_physiology3.01384607
13MP0000377_abnormal_hair_follicle2.87882150
14MP0003705_abnormal_hypodermis_morpholog2.31811463
15MP0003283_abnormal_digestive_organ2.24606250
16MP0004510_myositis2.22849587
17MP0002254_reproductive_system_inflammat2.19719567
18MP0003878_abnormal_ear_physiology2.15236955
19MP0005377_hearing/vestibular/ear_phenot2.15236955
20MP0001216_abnormal_epidermal_layer2.08957926
21MP0003453_abnormal_keratinocyte_physiol2.04411186
22MP0000462_abnormal_digestive_system1.93725818
23MP0010771_integument_phenotype1.90116424
24MP0004947_skin_inflammation1.87959371
25MP0000537_abnormal_urethra_morphology1.81526592
26MP0000367_abnormal_coat/_hair1.75857810
27MP0002938_white_spotting1.69873420
28MP0001243_abnormal_dermal_layer1.68022491
29MP0002060_abnormal_skin_morphology1.63068859
30MP0000762_abnormal_tongue_morphology1.59823545
31MP0005171_absent_coat_pigmentation1.58343731
32MP0003011_delayed_dark_adaptation1.54251182
33MP0003690_abnormal_glial_cell1.52448310
34MP0003195_calcinosis1.45486047
35MP0000467_abnormal_esophagus_morphology1.45182222
36MP0002095_abnormal_skin_pigmentation1.37557651
37MP0005647_abnormal_sex_gland1.32286933
38MP0005075_abnormal_melanosome_morpholog1.23300781
39MP0000566_synostosis1.22203523
40MP0003724_increased_susceptibility_to1.17230841
41MP0003075_altered_response_to1.15729458
42MP0006082_CNS_inflammation1.13396745
43MP0004272_abnormal_basement_membrane1.10421526
44MP0003315_abnormal_perineum_morphology1.07144045
45MP0002249_abnormal_larynx_morphology1.05505461
46MP0000465_gastrointestinal_hemorrhage1.05016663
47MP0009931_abnormal_skin_appearance1.04110199
48MP0003950_abnormal_plasma_membrane1.04027043
49MP0003938_abnormal_ear_development1.03341567
50MP0005451_abnormal_body_composition1.02703039
51MP0003566_abnormal_cell_adhesion1.01663437
52MP0001919_abnormal_reproductive_system1.01463043
53MP0005083_abnormal_biliary_tract1.00001731
54MP0009785_altered_susceptibility_to0.98558653
55MP0001340_abnormal_eyelid_morphology0.98048170
56MP0004885_abnormal_endolymph0.97076916
57MP0005360_urolithiasis0.96491987
58MP0008877_abnormal_DNA_methylation0.94820966
59MP0005409_darkened_coat_color0.90670511
60MP0009780_abnormal_chondrocyte_physiolo0.90404955
61MP0003959_abnormal_lean_body0.90248197
62MP0005423_abnormal_somatic_nervous0.88119806
63MP0003941_abnormal_skin_development0.87881673
64MP0000516_abnormal_urinary_system0.87454325
65MP0005367_renal/urinary_system_phenotyp0.87454325
66MP0003300_gastrointestinal_ulcer0.85375710
67MP0001191_abnormal_skin_condition0.82268676
68MP0001440_abnormal_grooming_behavior0.82043641
69MP0004142_abnormal_muscle_tone0.77856137
70MP0003136_yellow_coat_color0.76396443
71MP0002148_abnormal_hypersensitivity_rea0.76322247
72MP0005646_abnormal_pituitary_gland0.75805948
73MP0001346_abnormal_lacrimal_gland0.75173166
74MP0009384_cardiac_valve_regurgitation0.74309202
75MP0000920_abnormal_myelination0.73964941
76MP0009764_decreased_sensitivity_to0.73598590
77MP0002234_abnormal_pharynx_morphology0.72348473
78MP0000470_abnormal_stomach_morphology0.70927222
79MP0005174_abnormal_tail_pigmentation0.69824346
80MP0000015_abnormal_ear_pigmentation0.68430463
81MP0005085_abnormal_gallbladder_physiolo0.65707735
82MP0004264_abnormal_extraembryonic_tissu0.64612303
83MP0005025_abnormal_response_to0.62433563
84MP0001853_heart_inflammation0.60796470
85MP0004858_abnormal_nervous_system0.59323190
86MP0009379_abnormal_foot_pigmentation0.59061812
87MP0003191_abnormal_cellular_cholesterol0.58167402
88MP0003385_abnormal_body_wall0.57728863
89MP0004742_abnormal_vestibular_system0.57684015
90MP0009333_abnormal_splenocyte_physiolog0.57432017
91MP0001851_eye_inflammation0.56386330
92MP0008995_early_reproductive_senescence0.55353799
93MP0001188_hyperpigmentation0.54139915
94MP0009053_abnormal_anal_canal0.53461247
95MP0000013_abnormal_adipose_tissue0.53178588
96MP0010030_abnormal_orbit_morphology0.52272398
97MP0004270_analgesia0.49636140
98MP0002090_abnormal_vision0.49201761
99MP0005389_reproductive_system_phenotype0.49198262
100MP0004019_abnormal_vitamin_homeostasis0.49087841
101MP0005000_abnormal_immune_tolerance0.49083214
102MP0000639_abnormal_adrenal_gland0.48542055
103MP0005381_digestive/alimentary_phenotyp0.48456599
104MP0003755_abnormal_palate_morphology0.48362290
105MP0003123_paternal_imprinting0.47489657
106MP0003828_pulmonary_edema0.45995101
107MP0004859_abnormal_synaptic_plasticity0.45755137
108MP0006035_abnormal_mitochondrial_morpho0.44225340
109MP0003786_premature_aging0.43538146
110MP0006072_abnormal_retinal_apoptosis0.43250666
111MP0002282_abnormal_trachea_morphology0.42403824
112MP0004130_abnormal_muscle_cell0.41563485
113MP0003448_altered_tumor_morphology0.41530106
114MP0001485_abnormal_pinna_reflex0.41104537
115MP0009672_abnormal_birth_weight0.40566867
116MP0008057_abnormal_DNA_replication0.39947905
117MP0002006_tumorigenesis0.39405593
118MP0003942_abnormal_urinary_system0.38880684
119MP0000681_abnormal_thyroid_gland0.38370761
120MP0003045_fibrosis0.37463329
121MP0001784_abnormal_fluid_regulation0.35799835
122MP0003763_abnormal_thymus_physiology0.35561116
123MP0002970_abnormal_white_adipose0.35536324
124MP0005448_abnormal_energy_balance0.34879635
125MP0002971_abnormal_brown_adipose0.33270563
126MP0003635_abnormal_synaptic_transmissio0.32970613
127MP0005166_decreased_susceptibility_to0.32850436
128MP0000026_abnormal_inner_ear0.32368623
129MP0005164_abnormal_response_to0.32081370
130MP0003866_abnormal_defecation0.31598122
131MP0005248_abnormal_Harderian_gland0.31164254
132MP0000428_abnormal_craniofacial_morphol0.30626702
133MP0005535_abnormal_body_temperature0.30416139
134MP0002419_abnormal_innate_immunity0.30396499
135MP0005623_abnormal_meninges_morphology0.30156605
136MP0002064_seizures0.30038389
137MP0002177_abnormal_outer_ear0.29960043
138MP0002127_abnormal_cardiovascular_syste0.29319711
139MP0002111_abnormal_tail_morphology0.27980391
140MP0005410_abnormal_fertilization0.27869781
141MP0003936_abnormal_reproductive_system0.26826275
142MP0004043_abnormal_pH_regulation0.26325744
143MP0006138_congestive_heart_failure0.24367124
144MP0009703_decreased_birth_body0.23614209
145MP0004782_abnormal_surfactant_physiolog0.22819493
146MP0002109_abnormal_limb_morphology0.22464288
147MP0003115_abnormal_respiratory_system0.22005620
148MP0003119_abnormal_digestive_system0.20573960
149MP0001764_abnormal_homeostasis0.20306341
150MP0002089_abnormal_postnatal_growth/wei0.19124563
151MP0003567_abnormal_fetal_cardiomyocyte0.18513593
152MP0003638_abnormal_response/metabolism_0.17360585
153MP0002697_abnormal_eye_size0.16884426
154MP0001119_abnormal_female_reproductive0.16145502
155MP0008260_abnormal_autophagy0.15869882
156MP0005220_abnormal_exocrine_pancreas0.14955879

Predicted human phenotypes

RankGene SetZ-score
1* Woolly hair (HP:0002224)8.56933175
2Pili torti (HP:0003777)7.02739121
3Brittle hair (HP:0002299)6.41023543
4Absent eyelashes (HP:0000561)6.38135252
5* Abnormality of hair growth rate (HP:0011363)6.31033189
6* Slow-growing hair (HP:0002217)6.31033189
7Abnormality of nail color (HP:0100643)5.53882817
8Absent eyebrow (HP:0002223)5.21186103
9Fragile nails (HP:0001808)4.87839134
10Nail dystrophy (HP:0008404)4.85675754
11Alopecia of scalp (HP:0002293)4.64132730
12Palmoplantar hyperkeratosis (HP:0000972)4.63497503
13Follicular hyperkeratosis (HP:0007502)4.61172530
14Absent hair (HP:0002298)4.60169560
15Parakeratosis (HP:0001036)4.47044803
16Thick nail (HP:0001805)4.45743712
17Palmar hyperkeratosis (HP:0010765)4.32250692
18Gonadal dysgenesis (HP:0000133)4.17200993
19Plantar hyperkeratosis (HP:0007556)4.16658527
20Abnormal hair laboratory examination (HP:0003328)4.06770984
21Diaphragmatic weakness (HP:0009113)4.04815464
22Congenital ichthyosiform erythroderma (HP:0007431)3.79154513
23Congenital, generalized hypertrichosis (HP:0004540)3.76796741
24Abnormality of the axillary hair (HP:0100134)3.70576598
25Abnormality of secondary sexual hair (HP:0009888)3.70576598
26Increased IgE level (HP:0003212)3.68544893
27Stridor (HP:0010307)3.67605884
28Erythema (HP:0010783)3.62724214
29Hyperlipoproteinemia (HP:0010980)3.49583186
30Septate vagina (HP:0001153)3.32060515
31Hypoplastic left heart (HP:0004383)3.25921352
32* Fine hair (HP:0002213)3.25254310
33Mesangial abnormality (HP:0001966)3.11987318
34Intention tremor (HP:0002080)3.03392421
35Aplasia cutis congenita (HP:0001057)3.01099321
36Testicular neoplasm (HP:0010788)2.96759168
37Right ventricular cardiomyopathy (HP:0011663)2.92411019
38Sparse eyelashes (HP:0000653)2.92100729
39Onycholysis (HP:0001806)2.90690409
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.90564867
41Anomalous pulmonary venous return (HP:0010772)2.90363798
42Erythroderma (HP:0001019)2.89673307
43Turricephaly (HP:0000262)2.88244139
44Coronal craniosynostosis (HP:0004440)2.82391684
45Anteriorly placed anus (HP:0001545)2.82137617
46Milia (HP:0001056)2.80709037
47Widely patent fontanelles and sutures (HP:0004492)2.69954408
48Amelogenesis imperfecta (HP:0000705)2.69807709
49Abnormality of the pulmonary veins (HP:0011718)2.63731737
50Pustule (HP:0200039)2.58837010
51Corneal erosion (HP:0200020)2.55532201
52Abnormality of the parietal bone (HP:0002696)2.54707787
53Hypoplastic heart (HP:0001961)2.53539073
54Type I diabetes mellitus (HP:0100651)2.48301773
55Transposition of the great arteries (HP:0001669)2.46186685
56Abnormal connection of the cardiac segments (HP:0011545)2.46186685
57Abnormal ventriculo-arterial connection (HP:0011563)2.46186685
58Blepharitis (HP:0000498)2.30363333
59Akinesia (HP:0002304)2.26069257
60Abnormality of the frontal sinuses (HP:0002687)2.25068972
61Abnormal hemoglobin (HP:0011902)2.23494329
62Recurrent corneal erosions (HP:0000495)2.21898165
63Abnormality of placental membranes (HP:0011409)2.20630534
64Amniotic constriction ring (HP:0009775)2.20630534
65Abnormal blistering of the skin (HP:0008066)2.20506538
66Hand muscle atrophy (HP:0009130)2.19197083
67Oral leukoplakia (HP:0002745)2.17606217
68Neck muscle weakness (HP:0000467)2.15220351
69Large earlobe (HP:0009748)2.14604684
70Prolonged neonatal jaundice (HP:0006579)2.08262864
71Alacrima (HP:0000522)2.06157505
72Pruritus (HP:0000989)2.00822621
73* Hypotrichosis (HP:0001006)10.4215350
74Xanthomatosis (HP:0000991)1.99163091
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98987045
76Degeneration of the lateral corticospinal tracts (HP:0002314)1.98987045
77Hamartoma of the eye (HP:0010568)1.98023294
78Exocrine pancreatic insufficiency (HP:0001738)1.98017657
79Sparse scalp hair (HP:0002209)1.95666646
80Spinal muscular atrophy (HP:0007269)1.91994605
81Intrahepatic cholestasis (HP:0001406)1.90742611
82Hypohidrosis (HP:0000966)1.90630075
83Degeneration of anterior horn cells (HP:0002398)1.88758232
84Abnormality of the anterior horn cell (HP:0006802)1.88758232
85Concave nail (HP:0001598)1.87046477
86Gangrene (HP:0100758)1.85088867
87Round ear (HP:0100830)1.84301339
88Abnormality of the costochondral junction (HP:0000919)1.83434098
89Tongue fasciculations (HP:0001308)1.83287730
90Congenital sensorineural hearing impairment (HP:0008527)1.82262950
91Abnormality of the vocal cords (HP:0008777)1.81836616
92Abnormality of the dental pulp (HP:0006479)1.81641312
93Ridged nail (HP:0001807)1.81178746
94Rectal fistula (HP:0100590)1.80704172
95Rectovaginal fistula (HP:0000143)1.80704172
96Recurrent bacterial skin infections (HP:0005406)1.74948074
97* Abnormality of the pupil (HP:0000615)1.74506200
98Hypoplasia of the fovea (HP:0007750)1.74442619
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.74442619
100Palmoplantar keratoderma (HP:0000982)1.73917962
101Distal upper limb amyotrophy (HP:0007149)1.72384736
102Upper limb amyotrophy (HP:0009129)1.72384736
103Renal cortical cysts (HP:0000803)1.72383017
104Germ cell neoplasia (HP:0100728)1.70483003
105Ventricular fibrillation (HP:0001663)1.69128341
106Ankle clonus (HP:0011448)1.68368612
107Neonatal short-limb short stature (HP:0008921)1.67996925
108Rectal prolapse (HP:0002035)1.66536643
109Facial diplegia (HP:0001349)1.65779699
110Neurofibrillary tangles (HP:0002185)1.65337878
111Proximal placement of thumb (HP:0009623)1.64412396
112Buphthalmos (HP:0000557)1.63948337
113Hemorrhage of the eye (HP:0011885)1.63857663
114Abnormality of permanent molar morphology (HP:0011071)1.63754472
115Abnormality of the dental root (HP:0006486)1.63754472
116Taurodontia (HP:0000679)1.63754472
117Male pseudohermaphroditism (HP:0000037)1.62787135
118Autoamputation (HP:0001218)1.61457291
119Eczematoid dermatitis (HP:0000976)1.61360026
120Vaginal fistula (HP:0004320)1.61245292
121Muscle fibrillation (HP:0010546)1.61182254
122Hypergammaglobulinemia (HP:0010702)1.61083099
123Abnormality of molar (HP:0011077)1.58824563
124Abnormality of molar morphology (HP:0011070)1.58824563
125Clumsiness (HP:0002312)1.58691744
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.58486340
127Abnormal sex determination (HP:0012244)1.57403400
128Sex reversal (HP:0012245)1.57403400
129Abnormal pancreas size (HP:0012094)1.56202899
130Natal tooth (HP:0000695)1.55724812
131Conjunctival hamartoma (HP:0100780)1.55063038
132Aplasia of the phalanges of the hand (HP:0009802)1.54851942
133Aplasia involving bones of the extremities (HP:0009825)1.54851942
134Aplasia involving bones of the upper limbs (HP:0009823)1.54851942
135Renal Fanconi syndrome (HP:0001994)1.52923124
136Ventricular tachycardia (HP:0004756)1.51525286
137Stenosis of the external auditory canal (HP:0000402)1.50495240
138True hermaphroditism (HP:0010459)1.50279000
139Male infertility (HP:0003251)1.49012247
140Wide cranial sutures (HP:0010537)1.48817589
141Split foot (HP:0001839)1.47860509
142Esophageal atresia (HP:0002032)1.46773598
143Deviation of the thumb (HP:0009603)1.45159643
144Bulbar palsy (HP:0001283)1.43265738
145Hypoplastic ischia (HP:0003175)1.42997797
146Lip pit (HP:0100267)1.42500770
147Urinary urgency (HP:0000012)1.39323385
148Laryngomalacia (HP:0001601)1.37785214
149Abnormality of the corticospinal tract (HP:0002492)1.33859705
150Myopathic facies (HP:0002058)1.33828656
151Primary adrenal insufficiency (HP:0008207)1.32925827
152Hyperglycinemia (HP:0002154)1.28928541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.09927801
2RPS6KA44.25499119
3TAF14.22767473
4NME14.16669566
5MARK14.08918468
6EPHB23.63195660
7PASK3.28111060
8MST43.25854546
9BCR2.72392037
10PIK3CG2.70427899
11AKT32.67182891
12CDK192.50361270
13MAP3K112.47572516
14CASK2.39457815
15MAPK152.36653409
16TNIK2.30051775
17EIF2AK12.29926378
18IKBKE2.29680923
19DDR22.26915247
20MET2.24161693
21FGFR22.11807856
22PRPF4B2.03357939
23TBK11.98089749
24BMX1.97518365
25RIPK41.89295215
26RPS6KA61.74474125
27SMG11.74104702
28EIF2AK21.72062076
29TYRO31.71591808
30EEF2K1.71110371
31LMTK21.69473831
32FGR1.68567409
33MAP3K131.67069934
34MST1R1.59910872
35STK391.59466477
36KSR21.55523911
37MAP3K141.55522288
38STK161.51994663
39ACVR1B1.50182029
40MAP3K61.45830190
41RPS6KB21.45324252
42ICK1.42594388
43CAMK41.31014399
44BRAF1.30936922
45PBK1.27280241
46CSK1.26787870
47MATK1.26384753
48OXSR11.26077228
49PNCK1.23966976
50CHUK1.20639143
51MYLK1.18060797
52IRAK31.12809810
53SGK21.12252924
54PIM11.09856413
55VRK21.09737028
56RIPK11.08218681
57CSNK1G11.03138666
58FGFR10.98288861
59MAPKAPK30.98115887
60TRPM70.95393835
61UHMK10.94466217
62BLK0.94188633
63NEK60.86960962
64MAPKAPK50.85905492
65ARAF0.85845504
66SGK2230.84881174
67SGK4940.84881174
68HIPK20.84026961
69PTK60.82678089
70SCYL20.82208950
71EIF2AK30.78003020
72CSNK1G30.77402766
73STK240.75420692
74CDK90.75274731
75RPS6KA20.74181129
76AURKA0.73323195
77TAOK20.73194456
78FER0.72406689
79SGK30.71206569
80CSNK1A1L0.70256151
81RPS6KC10.66517852
82RPS6KL10.66517852
83KSR10.65635443
84PAK30.64322094
85EPHB10.64140377
86FGFR30.63599669
87MAP3K90.62955517
88MAP2K60.62857404
89RPS6KA50.61297024
90ERBB20.56828791
91MAPK130.54712777
92NEK90.54071458
93ROCK20.53544426
94ABL20.53488641
95PRKD10.53287069
96RPS6KB10.53253609
97PRKD20.53248665
98CSNK1G20.53186025
99PKN10.53165761
100CDK40.50504861
101CAMK2D0.50281513
102CAMK2B0.49404681
103MAP3K10.48471290
104ADRBK20.46196480
105LIMK10.46153998
106DYRK1B0.46003054
107CDC42BPA0.45956991
108GSK3A0.45601871
109MAP4K10.45282650
110MINK10.45187312
111MAPK40.44360705
112PRKCZ0.44085859
113GRK10.42266041
114INSRR0.42206239
115LYN0.42187708
116SIK20.41992882
117ROCK10.41116746
118WNK40.40905948
119CAMK2A0.40642620
120PDPK10.40133468
121NTRK20.39708954
122PDK20.38871173
123KIT0.38823842
124BMPR1B0.36887407
125STK110.36720990
126MAP2K20.36500396
127MAP3K70.36115370
128MAPK70.35863781
129CDK70.35625884
130MARK20.34974966
131PDGFRA0.34300500
132MAPKAPK20.33363766
133PAK10.33338048
134FYN0.32879159
135NTRK30.32748157
136PRKCD0.32107622
137TGFBR10.32046691
138PTK20.31826660
139IKBKB0.31427374
140PINK10.30552857
141YES10.30400619
142INSR0.29730468
143MAPK120.29546557
144CAMKK10.29388535
145ERN10.28915117
146HCK0.27103590
147TNK20.26257557
148MAP2K10.26237197
149CAMK2G0.26180776
150JAK10.26107203
151PRKACA0.24126659
152SGK10.23937745
153RPS6KA30.21867758
154PRKACG0.20520934
155PRKAA20.20244914
156MAPK30.20044764
157RAF10.20026374
158MAP2K40.19189953
159MELK0.18341746
160RPS6KA10.18107903
161MOS0.18096468
162CDK120.14165052
163LATS10.13534648
164AURKB0.12909524
165MAP3K120.11689762
166CSNK1E0.11424204
167CSNK2A20.11384843
168CDK50.10828169

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049775.01106698
2Fatty acid elongation_Homo sapiens_hsa000623.56840992
3Steroid biosynthesis_Homo sapiens_hsa001002.93206534
4Oxidative phosphorylation_Homo sapiens_hsa001902.69948231
5Linoleic acid metabolism_Homo sapiens_hsa005912.58344972
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34167443
7Salmonella infection_Homo sapiens_hsa051322.19351387
8Rheumatoid arthritis_Homo sapiens_hsa053232.11910186
9Propanoate metabolism_Homo sapiens_hsa006402.06353067
10Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.02717041
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.00420996
12Ether lipid metabolism_Homo sapiens_hsa005651.95787235
13Alzheimers disease_Homo sapiens_hsa050101.85689162
14Collecting duct acid secretion_Homo sapiens_hsa049661.78291025
15Ribosome_Homo sapiens_hsa030101.74873003
16Arachidonic acid metabolism_Homo sapiens_hsa005901.68850753
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66416601
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65166789
19Vibrio cholerae infection_Homo sapiens_hsa051101.56839314
20Pertussis_Homo sapiens_hsa051331.52737162
21Graft-versus-host disease_Homo sapiens_hsa053321.48435872
22Phototransduction_Homo sapiens_hsa047441.48384177
23Parkinsons disease_Homo sapiens_hsa050121.45621915
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45176953
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42156250
26Type I diabetes mellitus_Homo sapiens_hsa049401.39554672
27Malaria_Homo sapiens_hsa051441.34558320
28PPAR signaling pathway_Homo sapiens_hsa033201.31189862
29Pyruvate metabolism_Homo sapiens_hsa006201.30866314
30Retinol metabolism_Homo sapiens_hsa008301.28253757
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27161257
32Mineral absorption_Homo sapiens_hsa049781.25985016
33Legionellosis_Homo sapiens_hsa051341.25423607
34Staphylococcus aureus infection_Homo sapiens_hsa051501.24826248
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23926205
36Axon guidance_Homo sapiens_hsa043601.22888128
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22542207
38Fatty acid biosynthesis_Homo sapiens_hsa000611.21375763
39Prion diseases_Homo sapiens_hsa050201.19314135
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17453604
41Cardiac muscle contraction_Homo sapiens_hsa042601.17252882
42Ovarian steroidogenesis_Homo sapiens_hsa049131.14678699
43Glutathione metabolism_Homo sapiens_hsa004801.14267409
44Salivary secretion_Homo sapiens_hsa049701.12526845
45Amoebiasis_Homo sapiens_hsa051461.09588146
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07164106
47Phagosome_Homo sapiens_hsa041451.06788952
48Sphingolipid signaling pathway_Homo sapiens_hsa040711.05670753
49Huntingtons disease_Homo sapiens_hsa050161.04057994
50VEGF signaling pathway_Homo sapiens_hsa043701.03868821
51Tight junction_Homo sapiens_hsa045301.03742326
52Nicotine addiction_Homo sapiens_hsa050331.03646671
53Long-term potentiation_Homo sapiens_hsa047201.02833518
54Shigellosis_Homo sapiens_hsa051310.97145532
55Phenylalanine metabolism_Homo sapiens_hsa003600.96799329
56ECM-receptor interaction_Homo sapiens_hsa045120.96679535
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.95878224
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93336078
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.92250600
60Lysosome_Homo sapiens_hsa041420.91308533
61Hedgehog signaling pathway_Homo sapiens_hsa043400.90661115
62Basal cell carcinoma_Homo sapiens_hsa052170.88293580
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87918163
64Synaptic vesicle cycle_Homo sapiens_hsa047210.87653161
65Acute myeloid leukemia_Homo sapiens_hsa052210.84108204
66GABAergic synapse_Homo sapiens_hsa047270.80585647
67beta-Alanine metabolism_Homo sapiens_hsa004100.80576915
68Dorso-ventral axis formation_Homo sapiens_hsa043200.80452910
69African trypanosomiasis_Homo sapiens_hsa051430.80116218
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.79240780
71Glycerolipid metabolism_Homo sapiens_hsa005610.78569409
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75737002
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73959384
74Fatty acid metabolism_Homo sapiens_hsa012120.73915534
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72990138
76Sphingolipid metabolism_Homo sapiens_hsa006000.72474401
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.72464573
78Long-term depression_Homo sapiens_hsa047300.70275612
79Fatty acid degradation_Homo sapiens_hsa000710.70265189
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70124121
81Leishmaniasis_Homo sapiens_hsa051400.69530745
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67533927
83Pancreatic secretion_Homo sapiens_hsa049720.67268979
84Nitrogen metabolism_Homo sapiens_hsa009100.66911440
85Thyroid cancer_Homo sapiens_hsa052160.66557909
86Gastric acid secretion_Homo sapiens_hsa049710.65617618
87Melanogenesis_Homo sapiens_hsa049160.64897977
88Renin secretion_Homo sapiens_hsa049240.63696015
89Glioma_Homo sapiens_hsa052140.63163111
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62980524
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61729773
92Tuberculosis_Homo sapiens_hsa051520.61652881
93Hepatitis C_Homo sapiens_hsa051600.60795245
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.60694013
95Fat digestion and absorption_Homo sapiens_hsa049750.60302493
96Proteoglycans in cancer_Homo sapiens_hsa052050.59760838
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59198988
98Peroxisome_Homo sapiens_hsa041460.58926017
99Hematopoietic cell lineage_Homo sapiens_hsa046400.58921790
100ABC transporters_Homo sapiens_hsa020100.57904339
101Arginine and proline metabolism_Homo sapiens_hsa003300.56970455
102Estrogen signaling pathway_Homo sapiens_hsa049150.56854564
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56729548
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56167646
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55826587
106Cocaine addiction_Homo sapiens_hsa050300.54886472
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53913504
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52077671
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50231069
110Histidine metabolism_Homo sapiens_hsa003400.49919818
111Ras signaling pathway_Homo sapiens_hsa040140.49053767
112Butanoate metabolism_Homo sapiens_hsa006500.48573279
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48111870
114Calcium signaling pathway_Homo sapiens_hsa040200.48111857
115GnRH signaling pathway_Homo sapiens_hsa049120.47895424
116Chemokine signaling pathway_Homo sapiens_hsa040620.47815341
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47494542
118Prolactin signaling pathway_Homo sapiens_hsa049170.47211388
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.46957486
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.45939420
121Prostate cancer_Homo sapiens_hsa052150.45927687
122Hippo signaling pathway_Homo sapiens_hsa043900.45917588
123Notch signaling pathway_Homo sapiens_hsa043300.45250853
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45033342
125Complement and coagulation cascades_Homo sapiens_hsa046100.44877224
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44244030
127Osteoclast differentiation_Homo sapiens_hsa043800.43754107
128Carbon metabolism_Homo sapiens_hsa012000.42519073
129cAMP signaling pathway_Homo sapiens_hsa040240.41999543
130Glutamatergic synapse_Homo sapiens_hsa047240.41809231
131Asthma_Homo sapiens_hsa053100.40183010
132Insulin secretion_Homo sapiens_hsa049110.40069677
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39675957
134Oocyte meiosis_Homo sapiens_hsa041140.38477728
135Serotonergic synapse_Homo sapiens_hsa047260.38449212
136Insulin resistance_Homo sapiens_hsa049310.38448000
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37546558
138ErbB signaling pathway_Homo sapiens_hsa040120.36879276
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36665931
140Pancreatic cancer_Homo sapiens_hsa052120.36139577
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33825042
142Bladder cancer_Homo sapiens_hsa052190.30960343
143Oxytocin signaling pathway_Homo sapiens_hsa049210.29750431
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26280112
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.24280767
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23097819
147Amphetamine addiction_Homo sapiens_hsa050310.22629311
148B cell receptor signaling pathway_Homo sapiens_hsa046620.22286527
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21529810
150Chronic myeloid leukemia_Homo sapiens_hsa052200.20512454
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19719560
152TGF-beta signaling pathway_Homo sapiens_hsa043500.19577047
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18890130
154Insulin signaling pathway_Homo sapiens_hsa049100.18796394
155Melanoma_Homo sapiens_hsa052180.18674307
156Circadian entrainment_Homo sapiens_hsa047130.17435640
157T cell receptor signaling pathway_Homo sapiens_hsa046600.14905037
158Olfactory transduction_Homo sapiens_hsa047400.14600075
159Endometrial cancer_Homo sapiens_hsa052130.14574666

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