KRT75

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-substrate junction assembly (GO:0007044)8.87342646
2adhesion of symbiont to host cell (GO:0044650)8.07248541
3virion attachment to host cell (GO:0019062)8.07248541
4peptide cross-linking (GO:0018149)7.94428257
5establishment of skin barrier (GO:0061436)7.52237083
6hair follicle morphogenesis (GO:0031069)7.11658487
7adhesion of symbiont to host (GO:0044406)6.72039823
8regulation of water loss via skin (GO:0033561)6.64998407
9citrulline biosynthetic process (GO:0019240)6.62514294
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.56751178
11skin morphogenesis (GO:0043589)6.45693580
12keratinocyte differentiation (GO:0030216)6.42129244
13epidermis development (GO:0008544)6.39305005
14regulation of keratinocyte proliferation (GO:0010837)6.06853590
15intermediate filament cytoskeleton organization (GO:0045104)6.02690947
16intermediate filament-based process (GO:0045103)5.83328095
17surfactant homeostasis (GO:0043129)5.82569487
18epidermal cell differentiation (GO:0009913)5.54655970
19hemidesmosome assembly (GO:0031581)5.41315748
20atrioventricular valve morphogenesis (GO:0003181)5.32445560
21cell adhesion mediated by integrin (GO:0033627)5.29878910
22hair cycle process (GO:0022405)5.08592527
23molting cycle process (GO:0022404)5.08592527
24dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.07883968
25cell wall macromolecule catabolic process (GO:0016998)4.96503924
26cell wall macromolecule metabolic process (GO:0044036)4.96503924
27chemical homeostasis within a tissue (GO:0048875)4.89413919
28endodermal cell differentiation (GO:0035987)4.80186434
29multicellular organismal water homeostasis (GO:0050891)4.71560603
30chondrocyte development (GO:0002063)4.60670379
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.54766296
32mesodermal cell differentiation (GO:0048333)4.38274180
33citrulline metabolic process (GO:0000052)4.33591532
34endocardial cushion morphogenesis (GO:0003203)4.15572992
35regulation of glucocorticoid metabolic process (GO:0031943)4.05739073
36keratinocyte development (GO:0003334)4.04168004
37G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.96435165
38regulation of transforming growth factor beta2 production (GO:0032909)3.96157752
39water homeostasis (GO:0030104)3.89963173
40negative regulation of keratinocyte proliferation (GO:0010839)3.88129226
41polarized epithelial cell differentiation (GO:0030859)3.80720574
42negative regulation of chondrocyte differentiation (GO:0032331)3.74966485
43negative regulation of hormone biosynthetic process (GO:0032353)3.73653101
44negative regulation of hormone metabolic process (GO:0032351)3.73653101
45protein localization to endosome (GO:0036010)3.69972932
46epithelial cell differentiation involved in prostate gland development (GO:0060742)3.61485246
47cell surface receptor signaling pathway involved in heart development (GO:0061311)3.60180498
48cell junction assembly (GO:0034329)3.57757237
49hair follicle development (GO:0001942)3.54104661
50peptidyl-arginine modification (GO:0018195)3.53006705
51positive regulation of odontogenesis (GO:0042482)3.51216174
52positive regulation of keratinocyte differentiation (GO:0045618)3.49498365
53ectoderm development (GO:0007398)3.48320995
54renal filtration (GO:0097205)3.47866951
55gland morphogenesis (GO:0022612)3.41566536
56peptidyl-tyrosine autophosphorylation (GO:0038083)3.41412718
57hypotonic response (GO:0006971)3.40403259
58cell junction organization (GO:0034330)3.39714502
59hair cell differentiation (GO:0035315)3.36895285
60mesenchyme morphogenesis (GO:0072132)3.32174491
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28101199
62epithelium development (GO:0060429)3.27300550
63regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.26642428
64negative regulation of epidermis development (GO:0045683)3.25297534
65tooth mineralization (GO:0034505)3.19615616
66renal system development (GO:0072001)3.18329965
67L-serine transport (GO:0015825)3.16240454
68cell communication involved in cardiac conduction (GO:0086065)3.10671849
69positive regulation of astrocyte differentiation (GO:0048711)3.08346730
70positive regulation of meiotic cell cycle (GO:0051446)3.06258732
71extracellular matrix disassembly (GO:0022617)3.04490894
72positive regulation of cartilage development (GO:0061036)3.04383378
73positive regulation of epidermis development (GO:0045684)3.02755700
74heart valve morphogenesis (GO:0003179)3.00240690
75cellular copper ion homeostasis (GO:0006878)3.00053714
76molting cycle (GO:0042303)27.1686827
77hair cycle (GO:0042633)27.1686827
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98425703
79ventricular cardiac muscle cell action potential (GO:0086005)2.95727692
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.94712966
81regulation of keratinocyte differentiation (GO:0045616)2.93857217
82positive regulation of hair cycle (GO:0042635)2.93305539
83positive regulation of hair follicle development (GO:0051798)2.93305539
84non-canonical Wnt signaling pathway (GO:0035567)2.92256205
85positive regulation of p38MAPK cascade (GO:1900745)2.89972396
86cardiac right ventricle morphogenesis (GO:0003215)2.89218834
87lymph vessel development (GO:0001945)2.89151875
88mammary gland development (GO:0030879)2.88076128
89negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.85872157
90regulation of hair follicle development (GO:0051797)2.84453748
91cardiac epithelial to mesenchymal transition (GO:0060317)2.83694581
92gap junction assembly (GO:0016264)2.82328494
93epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.82003009
94fatty acid elongation (GO:0030497)2.80279903
95regulation of cardioblast differentiation (GO:0051890)2.79667496
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.78445812
97regulation of hair cycle (GO:0042634)2.78164654
98positive regulation of chondrocyte differentiation (GO:0032332)2.77873164
99cellular response to vitamin D (GO:0071305)2.77862869
100negative regulation of cell fate specification (GO:0009996)2.76224045
101regulation of transforming growth factor beta1 production (GO:0032908)2.76075108
102regulation of transforming growth factor beta production (GO:0071634)2.71737353
103long-chain fatty acid biosynthetic process (GO:0042759)2.70138254
104glial cell proliferation (GO:0014009)2.69276408
105wound healing (GO:0042060)2.69056531
106regulation of phospholipase A2 activity (GO:0032429)2.67938932
107serine transport (GO:0032329)2.67824670
108neural crest cell development (GO:0014032)2.66996900
109regulation of mesenchymal cell apoptotic process (GO:2001053)2.59766732
110phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59274064
111negative regulation of cartilage development (GO:0061037)2.58677551
112regulation of steroid hormone biosynthetic process (GO:0090030)2.58045553
113bone trabecula formation (GO:0060346)2.57532263
114skin development (GO:0043588)2.55660101
115fat-soluble vitamin catabolic process (GO:0042363)2.55460327
116vitamin catabolic process (GO:0009111)2.55460327
117mesenchymal cell proliferation (GO:0010463)2.54761426
118positive regulation of osteoblast proliferation (GO:0033690)2.49165301
119regulation of skeletal muscle cell differentiation (GO:2001014)2.47952732
120focal adhesion assembly (GO:0048041)2.44475687
121cell-substrate adherens junction assembly (GO:0007045)2.44475687
122positive regulation of protein export from nucleus (GO:0046827)2.43932320
123heparan sulfate proteoglycan metabolic process (GO:0030201)2.43876845
124regulation of epidermis development (GO:0045682)2.43535712
125negative regulation of interferon-gamma production (GO:0032689)2.43278447
126adherens junction organization (GO:0034332)2.42998517
127membrane tubulation (GO:0097320)2.42776577
128odontogenesis of dentin-containing tooth (GO:0042475)2.41116870
129regulation of protein localization to cell surface (GO:2000008)2.41039632
130establishment of epithelial cell polarity (GO:0090162)2.40802770
131epithelial cell proliferation (GO:0050673)2.40792144
132regulation of p38MAPK cascade (GO:1900744)2.39297507
133mammary gland epithelial cell proliferation (GO:0033598)2.38702930
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37531665
135positive regulation of epidermal cell differentiation (GO:0045606)2.37459730
136intestinal epithelial cell development (GO:0060576)2.37004734
137linoleic acid metabolic process (GO:0043651)2.36370352
138regulation of heart rate by cardiac conduction (GO:0086091)2.36017483
139keratinocyte proliferation (GO:0043616)2.35102325
140lateral sprouting from an epithelium (GO:0060601)2.34870966
141establishment of planar polarity (GO:0001736)2.34825554
142establishment of tissue polarity (GO:0007164)2.34825554
143cell proliferation involved in kidney development (GO:0072111)2.33511939
144regulation of apoptotic process involved in morphogenesis (GO:1902337)2.33281401
145oocyte development (GO:0048599)2.29996292
146positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.29335333
147regulation of ruffle assembly (GO:1900027)2.28827919
148regulation of epidermal cell differentiation (GO:0045604)2.28702739
149phosphatidylserine acyl-chain remodeling (GO:0036150)2.28289086
150positive regulation of monocyte chemotaxis (GO:0090026)2.24055209
151desmosome organization (GO:0002934)13.3723269
152keratinization (GO:0031424)10.9946748
153intermediate filament organization (GO:0045109)10.9909025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.89012472
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.18140173
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.79506834
4* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.17779302
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.74136867
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.50791219
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.41329984
8AR_21572438_ChIP-Seq_LNCaP_Human2.18022412
9TP63_17297297_ChIP-ChIP_HaCaT_Human13.7308623
10TRIM28_21343339_ChIP-Seq_HEK293_Human1.96526974
11ZNF263_19887448_ChIP-Seq_K562_Human1.78865781
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77755663
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77146369
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77146369
15CTCF_20526341_ChIP-Seq_ESCs_Human1.75208515
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69892279
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.66651426
18TP53_20018659_ChIP-ChIP_R1E_Mouse1.65416415
19* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.63329627
20EGR1_19032775_ChIP-ChIP_M12_Human1.63322845
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.53795105
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49127705
23CTCF_27219007_Chip-Seq_Bcells_Human1.46299219
24RACK7_27058665_Chip-Seq_MCF-7_Human1.40617898
25AHR_22903824_ChIP-Seq_MCF-7_Human1.38255156
26MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.37578066
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34528794
28E2F1_20622854_ChIP-Seq_HELA_Human1.34152566
29TP63_23658742_ChIP-Seq_EP156T_Human1.32835616
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32563372
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32517792
32TP63_22573176_ChIP-Seq_HFKS_Human1.31755834
33TP53_18474530_ChIP-ChIP_U2OS_Human1.31060892
34NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.29794759
35P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.29365608
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28892640
37NANOG_20526341_ChIP-Seq_ESCs_Human1.25030112
38CSB_26484114_Chip-Seq_FIBROBLAST_Human1.24119736
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23529469
40SOX2_20726797_ChIP-Seq_SW620_Human1.23323377
41LXR_22292898_ChIP-Seq_THP-1_Human1.22834370
42ATF3_27146783_Chip-Seq_COLON_Human1.21613652
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20370161
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19649995
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.19403173
46KLF5_25053715_ChIP-Seq_YYC3_Human1.18926633
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13504252
48TAF2_19829295_ChIP-Seq_ESCs_Human1.13158924
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10946818
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.10307964
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.10075283
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.09627964
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08615680
54* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08436561
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06740482
56* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06677897
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.05729955
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.05587753
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05418571
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04859273
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.04658224
62P53_21459846_ChIP-Seq_SAOS-2_Human1.04569691
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04436470
64CLOCK_20551151_ChIP-Seq_293T_Human1.02597953
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.01552423
66ERG_20517297_ChIP-Seq_VCAP_Human1.00582719
67IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99176601
68YY1_22570637_ChIP-Seq_MALME-3M_Human0.98049440
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97993299
70EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96822458
71RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96822458
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96410270
73GATA4_25053715_ChIP-Seq_YYC3_Human0.96256574
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.96253901
75CEBPB_22108803_ChIP-Seq_LS180_Human0.96000802
76RXR_22108803_ChIP-Seq_LS180_Human0.95698155
77GATA3_24758297_ChIP-Seq_MCF-7_Human0.95420060
78SMC4_20622854_ChIP-Seq_HELA_Human0.95374700
79RING1B_27294783_Chip-Seq_ESCs_Mouse0.95230098
80SA1_27219007_Chip-Seq_ERYTHROID_Human0.94795330
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94597171
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.94204452
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94159038
84BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93131100
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92989897
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91628378
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91597083
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91179390
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88489369
90JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88371066
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87556958
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87350416
93ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85609892
94EED_16625203_ChIP-ChIP_MESCs_Mouse0.85185705
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84588521
96CJUN_26792858_Chip-Seq_BT549_Human0.83750221
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81819746
98BCOR_27268052_Chip-Seq_Bcells_Human0.80641440
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80499227
100BCL6_27268052_Chip-Seq_Bcells_Human0.80207138
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.79596308
102SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79310508
103GATA6_21074721_ChIP-Seq_CACO-2_Human0.78093400
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77298698
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77232767
106PHF8_20622854_ChIP-Seq_HELA_Human0.76298944
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76219251
108BCAT_22108803_ChIP-Seq_LS180_Human0.75335046
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.75159009
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.75159009
111RING1B_27294783_Chip-Seq_NPCs_Mouse0.74589141
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.74562489
113MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72480789
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71728140
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.71488456
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71253397
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.70656037
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70124931
119TP53_16413492_ChIP-PET_HCT116_Human0.66957098
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66370758
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.66190221
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.63911020
123TP53_22127205_ChIP-Seq_IMR90_Human0.63211319
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.62473540
125BRD4_25478319_ChIP-Seq_HGPS_Human0.60581664
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59341478
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.58967567
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.58405368
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.57487562
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.57241866
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.55328362
132* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54529990
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54344230
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.53695032
135GATA6_25053715_ChIP-Seq_YYC3_Human0.52629127
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.52404699
137* TET1_21490601_ChIP-Seq_MESCs_Mouse0.51855842
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.51566192
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.49524230
140AR_21909140_ChIP-Seq_LNCAP_Human0.45407312
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.43732413
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.42750637
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.42026767
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.41540859
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.41439602
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.41439602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.88903013
2MP0005275_abnormal_skin_tensile6.65609600
3MP0002796_impaired_skin_barrier6.08415538
4* MP0002098_abnormal_vibrissa_morphology5.57261798
5* MP0000579_abnormal_nail_morphology5.52301789
6MP0000647_abnormal_sebaceous_gland5.09075080
7MP0010678_abnormal_skin_adnexa4.93472925
8MP0000383_abnormal_hair_follicle4.40635151
9MP0005501_abnormal_skin_physiology3.74236332
10* MP0000377_abnormal_hair_follicle3.36812673
11MP0000427_abnormal_hair_cycle2.93358473
12MP0003705_abnormal_hypodermis_morpholog2.72471683
13MP0002254_reproductive_system_inflammat2.61742924
14MP0001216_abnormal_epidermal_layer2.58785553
15MP0004381_abnormal_hair_follicle2.43531030
16MP0010771_integument_phenotype2.26545842
17MP0002060_abnormal_skin_morphology2.13573190
18MP0004947_skin_inflammation2.02365054
19MP0003453_abnormal_keratinocyte_physiol1.93492575
20* MP0000367_abnormal_coat/_hair1.81052434
21MP0001243_abnormal_dermal_layer1.78274088
22MP0000467_abnormal_esophagus_morphology1.74826990
23MP0003941_abnormal_skin_development1.62723113
24MP0000762_abnormal_tongue_morphology1.60975417
25MP0008260_abnormal_autophagy1.56176687
26MP0000537_abnormal_urethra_morphology1.40721375
27MP0003566_abnormal_cell_adhesion1.37285561
28MP0009931_abnormal_skin_appearance1.36949769
29MP0002234_abnormal_pharynx_morphology1.35243930
30MP0001346_abnormal_lacrimal_gland1.29927426
31MP0005409_darkened_coat_color1.19086069
32MP0001191_abnormal_skin_condition1.04711008
33MP0004782_abnormal_surfactant_physiolog1.03549269
34MP0009379_abnormal_foot_pigmentation0.99622444
35MP0008789_abnormal_olfactory_epithelium0.99117329
36MP0009053_abnormal_anal_canal0.98656877
37MP0010030_abnormal_orbit_morphology0.96265780
38MP0005360_urolithiasis0.95186913
39MP0004185_abnormal_adipocyte_glucose0.93824365
40MP0005257_abnormal_intraocular_pressure0.93803429
41MP0004134_abnormal_chest_morphology0.88500045
42MP0003755_abnormal_palate_morphology0.86213242
43MP0002249_abnormal_larynx_morphology0.85416462
44MP0003315_abnormal_perineum_morphology0.84959633
45MP0000538_abnormal_urinary_bladder0.84360048
46MP0002282_abnormal_trachea_morphology0.80021097
47MP0001340_abnormal_eyelid_morphology0.79007147
48MP0003329_amyloid_beta_deposits0.78364601
49MP0005499_abnormal_olfactory_system0.77258419
50MP0005394_taste/olfaction_phenotype0.77258419
51MP0004019_abnormal_vitamin_homeostasis0.74607548
52MP0003385_abnormal_body_wall0.73647001
53MP0000566_synostosis0.72393996
54MP0001851_eye_inflammation0.72119058
55MP0004272_abnormal_basement_membrane0.71374508
56MP0005075_abnormal_melanosome_morpholog0.69640544
57MP0001299_abnormal_eye_distance/0.66550955
58MP0000627_abnormal_mammary_gland0.64916570
59MP0000858_altered_metastatic_potential0.64736998
60MP0002095_abnormal_skin_pigmentation0.64231334
61MP0001849_ear_inflammation0.63850536
62MP0004264_abnormal_extraembryonic_tissu0.63448344
63MP0008438_abnormal_cutaneous_collagen0.62337402
64MP0002877_abnormal_melanocyte_morpholog0.61209036
65MP0002111_abnormal_tail_morphology0.60025546
66MP0001661_extended_life_span0.59141092
67MP0005623_abnormal_meninges_morphology0.56431473
68MP0003191_abnormal_cellular_cholesterol0.55172545
69MP0001784_abnormal_fluid_regulation0.54732903
70MP0005508_abnormal_skeleton_morphology0.53672227
71MP0000462_abnormal_digestive_system0.50115770
72MP0005451_abnormal_body_composition0.49679094
73MP0005023_abnormal_wound_healing0.49371777
74MP0009384_cardiac_valve_regurgitation0.48966373
75MP0002089_abnormal_postnatal_growth/wei0.48174920
76MP0003091_abnormal_cell_migration0.48033440
77MP0005197_abnormal_uvea_morphology0.46384063
78MP0005187_abnormal_penis_morphology0.45409027
79MP0003935_abnormal_craniofacial_develop0.44296511
80MP0005193_abnormal_anterior_eye0.44240044
81MP0001958_emphysema0.42899620
82MP0004885_abnormal_endolymph0.42110257
83MP0004858_abnormal_nervous_system0.39330797
84MP0001348_abnormal_lacrimal_gland0.38065009
85MP0009250_abnormal_appendicular_skeleto0.37647486
86MP0000013_abnormal_adipose_tissue0.36329909
87MP0010368_abnormal_lymphatic_system0.36180457
88MP0009780_abnormal_chondrocyte_physiolo0.35941994
89MP0002009_preneoplasia0.35630538
90MP0000163_abnormal_cartilage_morphology0.35064677
91MP0000465_gastrointestinal_hemorrhage0.34704292
92MP0003448_altered_tumor_morphology0.34188523
93MP0005621_abnormal_cell_physiology0.31740748
94MP0000428_abnormal_craniofacial_morphol0.31655421
95MP0010352_gastrointestinal_tract_polyps0.30550530
96MP0002177_abnormal_outer_ear0.30279962
97MP0003950_abnormal_plasma_membrane0.29976055
98MP0002109_abnormal_limb_morphology0.29350837
99MP0000432_abnormal_head_morphology0.29311702
100MP0001765_abnormal_ion_homeostasis0.29202045
101MP0005367_renal/urinary_system_phenotyp0.28937969
102MP0000516_abnormal_urinary_system0.28937969
103MP0003300_gastrointestinal_ulcer0.28443386
104MP0002697_abnormal_eye_size0.28375775
105MP0003045_fibrosis0.28373111
106MP0003937_abnormal_limbs/digits/tail_de0.28311046
107MP0001188_hyperpigmentation0.28239884
108MP0005388_respiratory_system_phenotype0.28186424
109MP0002133_abnormal_respiratory_system0.28186424
110MP0002115_abnormal_skeleton_extremities0.27846844
111MP0000049_abnormal_middle_ear0.27816324
112MP0002233_abnormal_nose_morphology0.27382123
113MP0004197_abnormal_fetal_growth/weight/0.27341337
114MP0003136_yellow_coat_color0.26440599
115MP0002896_abnormal_bone_mineralization0.24234075
116MP0005164_abnormal_response_to0.23681904
117MP0000470_abnormal_stomach_morphology0.22237688
118MP0006054_spinal_hemorrhage0.22108294
119MP0005248_abnormal_Harderian_gland0.21496950
120MP0006138_congestive_heart_failure0.21011114
121MP0000613_abnormal_salivary_gland0.20946394
122MP0002116_abnormal_craniofacial_bone0.20334982
123MP0005390_skeleton_phenotype0.19548338
124MP0003936_abnormal_reproductive_system0.19142593
125MP0002970_abnormal_white_adipose0.18006317
126MP0000678_abnormal_parathyroid_gland0.17819914
127MP0003011_delayed_dark_adaptation0.17411982
128MP0009703_decreased_birth_body0.17121159
129MP0005076_abnormal_cell_differentiation0.16939519
130MP0003763_abnormal_thymus_physiology0.16279002
131MP0005330_cardiomyopathy0.13301477
132MP0002932_abnormal_joint_morphology0.13069008

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.23348276
2Brittle hair (HP:0002299)8.99133215
3Pili torti (HP:0003777)7.93851197
4Abnormality of hair growth rate (HP:0011363)7.57255222
5Slow-growing hair (HP:0002217)7.57255222
6Abnormality of nail color (HP:0100643)6.37493106
7Onycholysis (HP:0001806)6.24320456
8Nail dystrophy (HP:0008404)5.73825671
9Fragile nails (HP:0001808)5.50792668
10Abnormal hair laboratory examination (HP:0003328)4.99909419
11Right ventricular cardiomyopathy (HP:0011663)4.83052688
12Erythroderma (HP:0001019)4.74609408
13Palmoplantar hyperkeratosis (HP:0000972)4.52897721
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.52014137
15Follicular hyperkeratosis (HP:0007502)4.50464139
16Congenital ichthyosiform erythroderma (HP:0007431)4.46747024
17Plantar hyperkeratosis (HP:0007556)4.34362381
18Palmar hyperkeratosis (HP:0010765)4.32696456
19Fine hair (HP:0002213)4.20922812
20Alopecia of scalp (HP:0002293)4.19112915
21Erythema (HP:0010783)4.17835302
22Thick nail (HP:0001805)4.10622956
23Hypoplasia of dental enamel (HP:0006297)3.86419496
24Parakeratosis (HP:0001036)3.65314045
25Pterygium (HP:0001059)3.56176963
26Sparse eyelashes (HP:0000653)3.53800373
27Milia (HP:0001056)3.22273821
28Fragile skin (HP:0001030)3.17683812
29Natal tooth (HP:0000695)3.15376454
30Congenital, generalized hypertrichosis (HP:0004540)3.14094018
31Oral leukoplakia (HP:0002745)3.10261676
32Selective tooth agenesis (HP:0001592)3.10048414
33Sparse scalp hair (HP:0002209)3.00639660
34Abnormality of the axillary hair (HP:0100134)2.94594224
35Abnormality of secondary sexual hair (HP:0009888)2.94594224
36Concave nail (HP:0001598)2.91117562
37Amelogenesis imperfecta (HP:0000705)2.83138292
38Acanthosis nigricans (HP:0000956)2.80704337
39Ridged nail (HP:0001807)2.76492160
40Hyperhidrosis (HP:0000975)2.74765498
41Abnormal blistering of the skin (HP:0008066)2.72129372
42Advanced eruption of teeth (HP:0006288)2.70630999
43Hypergammaglobulinemia (HP:0010702)2.69540644
44Popliteal pterygium (HP:0009756)2.64510409
45Hypodontia (HP:0000668)2.48875269
46Aplasia cutis congenita (HP:0001057)2.46360753
47Abnormality of the frontal sinuses (HP:0002687)2.44315371
48Curly hair (HP:0002212)2.39844851
49Ankyloglossia (HP:0010296)2.38918700
50Hypoplastic labia majora (HP:0000059)2.37518710
51Dry hair (HP:0011359)2.36158752
52Abnormality of the fingernails (HP:0001231)2.24894727
53Abnormality of the salivary glands (HP:0010286)2.23548046
54Esophageal atresia (HP:0002032)2.18442826
55Neurofibrillary tangles (HP:0002185)2.16452082
56Abnormality of the labia majora (HP:0012881)2.13930881
57Absent hair (HP:0002298)2.13416866
58Oligodontia (HP:0000677)2.12989019
59Pruritus (HP:0000989)2.10166412
60Palmoplantar keratoderma (HP:0000982)2.08660306
61Ventricular tachycardia (HP:0004756)2.03951138
62Hypotrichosis (HP:0001006)12.0552974
63Woolly hair (HP:0002224)10.2379552
64Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98888004
65Corneal erosion (HP:0200020)1.98715574
66Hypohidrosis (HP:0000966)1.98647636
67Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96903344
68Neck muscle weakness (HP:0000467)1.94989684
69Epidermoid cyst (HP:0200040)1.94833530
70Dehydration (HP:0001944)1.93552567
71Abnormality of oral frenula (HP:0000190)1.90593320
72Intention tremor (HP:0002080)1.88452931
73Skin ulcer (HP:0200042)1.88152002
74Fatigable weakness (HP:0003473)1.85156190
75Abnormality of the neuromuscular junction (HP:0003398)1.85156190
76Unilateral renal agenesis (HP:0000122)1.84763393
77Ureteral stenosis (HP:0000071)1.83140511
78Hyporeflexia of lower limbs (HP:0002600)1.81339552
79Abnormality of small intestinal villus morphology (HP:0011472)1.81212679
80Villous atrophy (HP:0011473)1.81212679
81Abnormality of the phalanges of the 5th finger (HP:0004213)1.79469900
82Ventricular fibrillation (HP:0001663)1.78760945
83Abnormality of the parietal bone (HP:0002696)1.78045044
84Absent eyelashes (HP:0000561)1.77583175
85Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.77411610
86Urticaria (HP:0001025)1.77134883
87Distal lower limb muscle weakness (HP:0009053)1.76925095
88Cerebral inclusion bodies (HP:0100314)1.74778042
89Abnormality of molar morphology (HP:0011070)1.74664484
90Abnormality of molar (HP:0011077)1.74664484
91Abnormality of the middle phalanges of the toes (HP:0010183)1.74506302
92Taurodontia (HP:0000679)1.74117271
93Abnormality of permanent molar morphology (HP:0011071)1.74117271
94Abnormality of the dental root (HP:0006486)1.74117271
95Bronchomalacia (HP:0002780)1.72088975
96Ureteral obstruction (HP:0006000)1.71807404
97Laryngomalacia (HP:0001601)1.68072366
98Cheilitis (HP:0100825)1.67376741
99Hoarse voice (HP:0001609)1.67191510
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65531395
101Abnormality of the gastric mucosa (HP:0004295)1.64043714
102Death in infancy (HP:0001522)1.63356202
103Lip pit (HP:0100267)1.62613147
104Blepharitis (HP:0000498)1.62384176
105Ectropion (HP:0000656)1.61821202
106Down-sloping shoulders (HP:0200021)1.61254111
107Increased connective tissue (HP:0009025)1.58881533
108Widely patent fontanelles and sutures (HP:0004492)1.57408907
109Torticollis (HP:0000473)1.56841983
110Sex reversal (HP:0012245)1.53228309
111Abnormal sex determination (HP:0012244)1.53228309
112Anonychia (HP:0001798)1.53204201
113Difficulty walking (HP:0002355)1.51677208
114Abnormality of the 2nd finger (HP:0004100)1.51558350
115Thickened helices (HP:0000391)1.51331882
116Recurrent corneal erosions (HP:0000495)1.51323622
117Septate vagina (HP:0001153)1.51072128
118Xerostomia (HP:0000217)1.50557567
119Abnormality of the dental pulp (HP:0006479)1.50224844
120Autoamputation (HP:0001218)1.49760012
121Carious teeth (HP:0000670)1.49482946
122Atrophic scars (HP:0001075)1.47898497
123Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.47806707
124Multifactorial inheritance (HP:0001426)1.47520232
125Pustule (HP:0200039)1.46643579
126Premature loss of primary teeth (HP:0006323)1.45807184
127Corneal dystrophy (HP:0001131)1.45762708
128Abnormality of dental color (HP:0011073)1.44268571
129Type 1 muscle fiber predominance (HP:0003803)1.43665958
130Labial hypoplasia (HP:0000066)1.42751359
131Breast hypoplasia (HP:0003187)1.42513773
132Humeroradial synostosis (HP:0003041)1.42190284
133Synostosis involving the elbow (HP:0003938)1.42190284
134Abnormality of the pupil (HP:0000615)1.41652102
135Abnormality of placental membranes (HP:0011409)1.41153347
136Amniotic constriction ring (HP:0009775)1.41153347
137Squamous cell carcinoma (HP:0002860)1.40227945
138Vertebral arch anomaly (HP:0008438)1.34147590
139Neonatal onset (HP:0003623)1.32576540
140Hypoplastic female external genitalia (HP:0012815)1.30598112
141Split foot (HP:0001839)1.29523388
142Hypoplasia of the uterus (HP:0000013)1.26818163
143Periodontitis (HP:0000704)1.26711458
144Tibial bowing (HP:0002982)1.25554834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.31938044
2ARAF4.22734050
3EPHB23.99581646
4FER3.79866617
5ERN13.73617255
6EPHA23.64803114
7NTRK13.57611687
8MAP3K63.57205198
9MAP3K33.03512117
10MAPKAPK32.94759229
11LATS12.67294087
12TAOK12.20853402
13PIK3CG1.93916796
14MUSK1.91064033
15MAP3K21.87806836
16PBK1.86905046
17STK241.80655205
18CDK191.72837279
19MST1R1.60781496
20LMTK21.59185008
21TRIB31.57300132
22EPHB11.56223540
23TTN1.55307314
24FGFR21.53449846
25RPS6KB21.46611335
26FLT31.45831290
27FGFR41.43020634
28LATS21.42314321
29MAP3K111.37972385
30BLK1.35325584
31TGFBR11.34406545
32PIM21.32382005
33FGFR31.31880855
34EPHA31.27927776
35MAP2K61.27840936
36CDK61.27448883
37NME11.26713751
38CSF1R1.19494845
39MAP3K71.14267260
40BRAF1.12149752
41LRRK21.11056814
42PTK61.10336626
43BMPR1B1.09569426
44EEF2K1.06194130
45CDK121.05604212
46RAF11.04357119
47OBSCN1.04318999
48MAP3K121.04227195
49EPHA40.97355735
50RPS6KA20.97099256
51ERBB40.96459671
52FGFR10.95774847
53MAP3K90.93643381
54MATK0.90846206
55MAP2K30.88916304
56STK38L0.88354643
57GRK10.88183260
58PDGFRA0.87960924
59MAP3K100.87829609
60PDGFRB0.84503144
61HIPK20.84340150
62MAP3K10.83325413
63RET0.82901200
64STK30.80631788
65MAPK110.78348134
66MAPKAPK20.77022910
67DMPK0.76385677
68SMG10.73291027
69TRPM70.72989953
70NEK60.72343763
71DYRK1B0.70365585
72PRPF4B0.66400669
73PTK20.65229235
74ERBB20.63936343
75MAP2K10.63265928
76CDC42BPA0.62755622
77MET0.59747755
78PRKD10.59207871
79RIPK10.55981880
80PKN10.55632894
81ACVR1B0.55085588
82BMX0.54905060
83CSNK1A1L0.54699191
84ROCK10.53922204
85JAK10.48277364
86WNK10.47829607
87SIK10.47719321
88IRAK30.47039373
89ILK0.46591235
90MTOR0.44540121
91PRKD20.44393029
92CSNK1E0.44188364
93MAPK120.41587829
94ADRBK10.41535218
95MAPKAPK50.41332259
96ERBB30.40692552
97DDR20.40374717
98CAMK1G0.40359077
99MELK0.40215407
100NME20.40079911
101PRKCH0.39583778
102NTRK20.39309959
103GSK3A0.38058651
104PRKCE0.37697147
105STK380.37442670
106PRKACG0.36536332
107MAPK40.35513692
108RPS6KL10.35504096
109RPS6KC10.35504096
110MAP3K80.35429244
111RPS6KA10.35411945
112MYLK0.34950833
113PHKG20.34941274
114PHKG10.34941274
115MST40.34573441
116JAK20.34455342
117KSR20.34335182
118INSR0.33332728
119MOS0.33240646
120RPS6KA40.32789486
121RPS6KB10.32347828
122DAPK20.32077466
123ICK0.31717152
124CLK10.30996934
125PAK40.30871691
126CSNK1D0.30770783
127TESK10.30168563
128ROCK20.30058815
129MAPK90.29137072
130PAK60.29106069
131IKBKB0.29023792
132KSR10.28653419
133PRKACA0.28532814
134JAK30.27550240
135NLK0.27433518
136CASK0.27362211
137PAK20.26945167
138FYN0.26567546
139IGF1R0.25448970
140ABL20.25125285
141TGFBR20.24528285
142PRKCI0.24251485
143EIF2AK20.24244245
144MAP2K20.23914531
145SRC0.23838152
146TSSK60.22689173
147RPS6KA60.21822959
148CAMK2G0.21625906
149ABL10.17710590

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.97566583
2Linoleic acid metabolism_Homo sapiens_hsa005913.26523356
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.17634872
4Fatty acid elongation_Homo sapiens_hsa000623.05616032
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.89072703
6Hedgehog signaling pathway_Homo sapiens_hsa043402.63966542
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.47338560
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38450529
9Fat digestion and absorption_Homo sapiens_hsa049752.14687966
10Hippo signaling pathway_Homo sapiens_hsa043902.12358461
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.04909002
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.04264945
13TGF-beta signaling pathway_Homo sapiens_hsa043502.03844168
14Melanogenesis_Homo sapiens_hsa049162.01435963
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91116487
16Phenylalanine metabolism_Homo sapiens_hsa003601.81523632
17Axon guidance_Homo sapiens_hsa043601.81360752
18Adherens junction_Homo sapiens_hsa045201.71826652
19Melanoma_Homo sapiens_hsa052181.70768881
20Proteoglycans in cancer_Homo sapiens_hsa052051.65772361
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63126661
22Ether lipid metabolism_Homo sapiens_hsa005651.58442702
23Retinol metabolism_Homo sapiens_hsa008301.50305633
24Bladder cancer_Homo sapiens_hsa052191.47885170
25Tight junction_Homo sapiens_hsa045301.45146468
26ECM-receptor interaction_Homo sapiens_hsa045121.40956031
27Arachidonic acid metabolism_Homo sapiens_hsa005901.36256895
28Ribosome_Homo sapiens_hsa030101.31359542
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30835264
30Wnt signaling pathway_Homo sapiens_hsa043101.30246216
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25677651
32Histidine metabolism_Homo sapiens_hsa003401.23439566
33Ras signaling pathway_Homo sapiens_hsa040141.22125368
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19764786
35Thyroid cancer_Homo sapiens_hsa052161.19208874
36VEGF signaling pathway_Homo sapiens_hsa043701.19184786
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.18755977
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14833783
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.12817179
40Rap1 signaling pathway_Homo sapiens_hsa040151.09651884
41Caffeine metabolism_Homo sapiens_hsa002321.05744693
42Mineral absorption_Homo sapiens_hsa049781.05144766
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05016500
44MicroRNAs in cancer_Homo sapiens_hsa052061.04729720
45Prion diseases_Homo sapiens_hsa050201.04183800
46Dorso-ventral axis formation_Homo sapiens_hsa043201.01380827
47Glioma_Homo sapiens_hsa052141.01117598
48Phototransduction_Homo sapiens_hsa047440.98340427
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.98013677
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97944749
51Amoebiasis_Homo sapiens_hsa051460.95811055
52GnRH signaling pathway_Homo sapiens_hsa049120.95698228
53Chronic myeloid leukemia_Homo sapiens_hsa052200.95471296
54Pancreatic cancer_Homo sapiens_hsa052120.94698162
55Acute myeloid leukemia_Homo sapiens_hsa052210.93831142
56Tyrosine metabolism_Homo sapiens_hsa003500.93473989
57Inositol phosphate metabolism_Homo sapiens_hsa005620.88061713
58Pathways in cancer_Homo sapiens_hsa052000.86203343
59Renal cell carcinoma_Homo sapiens_hsa052110.85716741
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85429148
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82668511
62Insulin signaling pathway_Homo sapiens_hsa049100.78409240
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77200327
64p53 signaling pathway_Homo sapiens_hsa041150.74468983
65Focal adhesion_Homo sapiens_hsa045100.74409087
66Glycerolipid metabolism_Homo sapiens_hsa005610.74330964
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72088498
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71973316
69Lysosome_Homo sapiens_hsa041420.71831473
70PPAR signaling pathway_Homo sapiens_hsa033200.71172660
71Pancreatic secretion_Homo sapiens_hsa049720.70233754
72MAPK signaling pathway_Homo sapiens_hsa040100.67238865
73Staphylococcus aureus infection_Homo sapiens_hsa051500.66734823
74Long-term potentiation_Homo sapiens_hsa047200.65849994
75Vitamin digestion and absorption_Homo sapiens_hsa049770.65656626
76Malaria_Homo sapiens_hsa051440.64477944
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.64431607
78Shigellosis_Homo sapiens_hsa051310.64165452
79Endometrial cancer_Homo sapiens_hsa052130.61423916
80Notch signaling pathway_Homo sapiens_hsa043300.59909760
81Protein digestion and absorption_Homo sapiens_hsa049740.59810658
82Apoptosis_Homo sapiens_hsa042100.59515639
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59295839
84Prostate cancer_Homo sapiens_hsa052150.59091835
85Long-term depression_Homo sapiens_hsa047300.58211603
86N-Glycan biosynthesis_Homo sapiens_hsa005100.56689042
87Non-small cell lung cancer_Homo sapiens_hsa052230.55305909
88Ovarian steroidogenesis_Homo sapiens_hsa049130.55177564
89Hepatitis C_Homo sapiens_hsa051600.55117718
90Steroid biosynthesis_Homo sapiens_hsa001000.54351645
91beta-Alanine metabolism_Homo sapiens_hsa004100.54124600
92Renin secretion_Homo sapiens_hsa049240.53750014
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53670252
94Dilated cardiomyopathy_Homo sapiens_hsa054140.53275251
95Estrogen signaling pathway_Homo sapiens_hsa049150.51774693
96Gastric acid secretion_Homo sapiens_hsa049710.51626158
97Platelet activation_Homo sapiens_hsa046110.51354219
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50635975
99ErbB signaling pathway_Homo sapiens_hsa040120.50335015
100Pertussis_Homo sapiens_hsa051330.49250705
101Small cell lung cancer_Homo sapiens_hsa052220.48204963
102HTLV-I infection_Homo sapiens_hsa051660.43841558
103Oxytocin signaling pathway_Homo sapiens_hsa049210.43534209
104Sphingolipid metabolism_Homo sapiens_hsa006000.43088920
105Fatty acid biosynthesis_Homo sapiens_hsa000610.42090589
106Salivary secretion_Homo sapiens_hsa049700.40139656
107Insulin resistance_Homo sapiens_hsa049310.39570255
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39551539
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39525285
110Endocytosis_Homo sapiens_hsa041440.39338345
111Phagosome_Homo sapiens_hsa041450.38893949
112Complement and coagulation cascades_Homo sapiens_hsa046100.38763442
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38440480
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.37687479
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37381508
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37096149
117Glucagon signaling pathway_Homo sapiens_hsa049220.37006371
118Tuberculosis_Homo sapiens_hsa051520.36916002
119Gap junction_Homo sapiens_hsa045400.36797435
120Olfactory transduction_Homo sapiens_hsa047400.36562995
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.36553272
122Hematopoietic cell lineage_Homo sapiens_hsa046400.34682449
123Choline metabolism in cancer_Homo sapiens_hsa052310.34594422
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34101762
125Salmonella infection_Homo sapiens_hsa051320.33324197
126Toxoplasmosis_Homo sapiens_hsa051450.33289120
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31154612
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30590342
129Chemical carcinogenesis_Homo sapiens_hsa052040.29887120
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29000303
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.26731024
132cAMP signaling pathway_Homo sapiens_hsa040240.26286416

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