KRT76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.80808156
2sarcoplasmic reticulum calcium ion transport (GO:0070296)8.86790241
3regulation of keratinocyte differentiation (GO:0045616)8.22738123
4regulation of toll-like receptor 4 signaling pathway (GO:0034143)7.04583603
5response to vitamin A (GO:0033189)6.85240584
6regulation of relaxation of muscle (GO:1901077)6.69098895
7purine nucleotide salvage (GO:0032261)6.11600337
8muscle organ morphogenesis (GO:0048644)6.10648349
9keratinocyte differentiation (GO:0030216)6.06563228
10skeletal muscle contraction (GO:0003009)5.80861325
11long-chain fatty acid biosynthetic process (GO:0042759)5.76271541
12regulation of secondary heart field cardioblast proliferation (GO:0003266)5.68383739
13regulation of cardioblast proliferation (GO:0003264)5.68383739
14regulation of skeletal muscle contraction (GO:0014819)5.56056394
15muscle filament sliding (GO:0030049)5.42332385
16actin-myosin filament sliding (GO:0033275)5.42332385
17regulation of skeletal muscle cell differentiation (GO:2001014)5.35998848
18innate immune response in mucosa (GO:0002227)5.29121820
19coronary vasculature morphogenesis (GO:0060977)5.21478438
20outer ear morphogenesis (GO:0042473)5.17369524
21tooth mineralization (GO:0034505)5.14765050
22linoleic acid metabolic process (GO:0043651)4.98432931
23regulation of epidermal cell differentiation (GO:0045604)4.92792443
24cellular response to epidermal growth factor stimulus (GO:0071364)4.84376866
25cellular response to retinoic acid (GO:0071300)4.77277387
26lymph vessel development (GO:0001945)4.63678162
27negative regulation of toll-like receptor signaling pathway (GO:0034122)4.48759757
28actin-mediated cell contraction (GO:0070252)4.37591936
29mucosal-associated lymphoid tissue development (GO:0048537)4.34519695
30Peyers patch development (GO:0048541)4.34519695
31lipoxygenase pathway (GO:0019372)4.20311111
32mucosal immune response (GO:0002385)4.12135877
33cellular response to glucocorticoid stimulus (GO:0071385)4.10773690
34epidermal cell differentiation (GO:0009913)4.10424566
35negative regulation of thymocyte apoptotic process (GO:0070244)4.04128550
36regulation of penile erection (GO:0060405)4.01225188
37creatine metabolic process (GO:0006600)4.00449293
38muscle cell fate commitment (GO:0042693)3.97738737
39response to epidermal growth factor (GO:0070849)3.97146242
40cellular response to corticosteroid stimulus (GO:0071384)3.95364440
41organ or tissue specific immune response (GO:0002251)3.88715038
42negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.86481979
43negative regulation of calcium ion transmembrane transport (GO:1903170)3.86481979
44histamine secretion (GO:0001821)3.85218894
45embryonic viscerocranium morphogenesis (GO:0048703)3.80561965
46plasma membrane repair (GO:0001778)3.60918975
47skeletal muscle adaptation (GO:0043501)3.60690715
48positive regulation of protein depolymerization (GO:1901881)3.60510755
49positive regulation of myotube differentiation (GO:0010831)3.54799941
50establishment of skin barrier (GO:0061436)3.53837047
51negative regulation of B cell apoptotic process (GO:0002903)3.50365331
52cranial nerve morphogenesis (GO:0021602)3.46785323
53regulation of epidermis development (GO:0045682)3.46715881
54mature B cell differentiation involved in immune response (GO:0002313)3.44761067
55response to vitamin E (GO:0033197)3.42872901
56response to muscle activity (GO:0014850)3.39432541
57actin filament-based movement (GO:0030048)3.36027710
58striated muscle contraction (GO:0006941)3.33367968
59tricarboxylic acid cycle (GO:0006099)3.30329292
60myotube differentiation (GO:0014902)3.26924899
61regulation of germinal center formation (GO:0002634)3.26072135
62bundle of His cell to Purkinje myocyte communication (GO:0086069)3.24976090
63negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.23514269
64regulation of water loss via skin (GO:0033561)3.20428117
65positive regulation of T cell differentiation in thymus (GO:0033089)3.20297754
66positive regulation of skeletal muscle tissue development (GO:0048643)3.12946351
67skeletal muscle tissue regeneration (GO:0043403)3.12521566
68desmosome organization (GO:0002934)3.09975609
69skeletal muscle fiber development (GO:0048741)3.04793144
70myofibril assembly (GO:0030239)3.04458105
71histamine transport (GO:0051608)3.00974683
72positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.00676080
73keratinization (GO:0031424)20.9218506
74sarcomere organization (GO:0045214)2.94265962
75regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.91999219
76nucleotide salvage (GO:0043173)2.87619521
77aorta morphogenesis (GO:0035909)2.86929888
78purine nucleobase biosynthetic process (GO:0009113)2.84618815
79pharyngeal system development (GO:0060037)2.82307975
80adenosine metabolic process (GO:0046085)2.80551464
81regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.74356764
82carnitine shuttle (GO:0006853)2.73571220
83regulation of calcium ion transmembrane transport (GO:1903169)2.70122664
84regulation of calcium ion transmembrane transporter activity (GO:1901019)2.70122664
85otic vesicle formation (GO:0030916)2.69452319
86purine deoxyribonucleotide catabolic process (GO:0009155)2.65071015
87epidermis development (GO:0008544)2.64950337
88negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.64021874
89regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.64016345
90negative regulation of circadian rhythm (GO:0042754)2.63153566
91multicellular organismal water homeostasis (GO:0050891)2.62729816
92aspartate family amino acid catabolic process (GO:0009068)2.61202923
93striated muscle adaptation (GO:0014888)2.58463685
94cochlea morphogenesis (GO:0090103)2.57484313
95positive regulation of protein complex disassembly (GO:0043243)2.57431375
96transcytosis (GO:0045056)2.56720262
97negative regulation of ion transmembrane transporter activity (GO:0032413)2.55675657
98cell wall macromolecule catabolic process (GO:0016998)14.6191148
99cell wall macromolecule metabolic process (GO:0044036)14.6191148
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)13.7809268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.78444707
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human8.50811144
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63232522
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.23845440
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.21293526
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38777815
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.35960620
8CTCF_27219007_Chip-Seq_Bcells_Human2.31366064
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16135110
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14521853
11CTCF_20526341_ChIP-Seq_ESCs_Human2.11532442
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07533192
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02731729
14ERG_20517297_ChIP-Seq_VCAP_Human2.02198476
15VDR_22108803_ChIP-Seq_LS180_Human1.95800149
16P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47362219
17ZNF263_19887448_ChIP-Seq_K562_Human1.45882893
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40956369
19GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.40733907
20RACK7_27058665_Chip-Seq_MCF-7_Human1.40073836
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39524332
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.38447343
23BCOR_27268052_Chip-Seq_Bcells_Human1.37431735
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37323406
25CLOCK_20551151_ChIP-Seq_293T_Human1.34843008
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34015706
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28197443
28GATA6_21074721_ChIP-Seq_CACO-2_Human1.26528723
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25421210
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24548072
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24314855
32CJUN_26792858_Chip-Seq_BT549_Human1.23301178
33NANOG_20526341_ChIP-Seq_ESCs_Human1.22901716
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17857735
35EGR1_19032775_ChIP-ChIP_M12_Human1.17781743
36RXR_22108803_ChIP-Seq_LS180_Human1.17512518
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.17316267
38FOXH1_21741376_ChIP-Seq_ESCs_Human1.16491222
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16367481
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14774701
41SMC4_20622854_ChIP-Seq_HELA_Human1.14389576
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13246207
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11219541
44SOX2_20726797_ChIP-Seq_SW620_Human1.11150086
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.10701104
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.10623917
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.10623917
48OCT1_27270436_Chip-Seq_PROSTATE_Human1.08220601
49P68_20966046_ChIP-Seq_HELA_Human1.05686105
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04616883
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.04007659
52CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01634401
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01455587
54LXR_22292898_ChIP-Seq_THP-1_Human1.01333891
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00192421
56PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98346383
57YY1_22570637_ChIP-Seq_MALME-3M_Human0.97999362
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97971546
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97662816
60GATA3_24758297_ChIP-Seq_MCF-7_Human0.96856729
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96399732
62BCL6_27268052_Chip-Seq_Bcells_Human0.93618527
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92354941
64JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92250233
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91883946
66KDM2B_26808549_Chip-Seq_DND41_Human0.91778300
67EZH2_27294783_Chip-Seq_ESCs_Mouse0.91697477
68EZH2_22144423_ChIP-Seq_EOC_Human0.91448617
69MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90637362
70GATA3_21878914_ChIP-Seq_MCF-7_Human0.90174064
71LXR_22158963_ChIP-Seq_LIVER_Mouse0.89353032
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89031381
73TP63_22573176_ChIP-Seq_HFKS_Human0.88912086
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88579906
75RUNX1_27514584_Chip-Seq_MCF-7_Human0.86719599
76RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85441198
77EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85441198
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85385533
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85331386
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85304599
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84584879
82ERA_21632823_ChIP-Seq_H3396_Human0.84520570
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84359446
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84072291
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83509224
86CEBPB_22108803_ChIP-Seq_LS180_Human0.83436639
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83387650
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82929479
89ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82896617
90P53_21459846_ChIP-Seq_SAOS-2_Human0.82533070
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.82168576
92RAC3_21632823_ChIP-Seq_H3396_Human0.81960293
93CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81906963
94DROSHA_22980978_ChIP-Seq_HELA_Human0.81780132
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81672906
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80955949
97TP53_20018659_ChIP-ChIP_R1E_Mouse0.80780081
98OCT4_20526341_ChIP-Seq_ESCs_Human0.80621831
99JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79223142
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.78870161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.45705195
2MP0003646_muscle_fatigue5.17377100
3MP0000751_myopathy5.03655703
4MP0002796_impaired_skin_barrier5.01585057
5MP0005275_abnormal_skin_tensile4.39564717
6MP0000749_muscle_degeneration3.95356992
7MP0000467_abnormal_esophagus_morphology3.82753735
8MP0000762_abnormal_tongue_morphology3.33412086
9MP0002837_dystrophic_cardiac_calcinosis3.30104345
10MP0009697_abnormal_copulation2.96521455
11MP0004145_abnormal_muscle_electrophysio2.96017665
12MP0005501_abnormal_skin_physiology2.74254740
13MP0000747_muscle_weakness2.70991245
14MP0002106_abnormal_muscle_physiology2.58508371
15MP0000759_abnormal_skeletal_muscle2.53306520
16MP0000678_abnormal_parathyroid_gland2.42862444
17MP0002095_abnormal_skin_pigmentation2.25823682
18MP0004185_abnormal_adipocyte_glucose2.16889237
19MP0003252_abnormal_bile_duct2.13877737
20MP0001243_abnormal_dermal_layer2.11242282
21MP0004087_abnormal_muscle_fiber2.11082688
22MP0005369_muscle_phenotype2.08020918
23MP0002254_reproductive_system_inflammat2.04626245
24MP0004036_abnormal_muscle_relaxation2.02730979
25MP0004130_abnormal_muscle_cell1.99695594
26MP0000750_abnormal_muscle_regeneration1.94681074
27MP0000733_abnormal_muscle_development1.91074684
28MP0002269_muscular_atrophy1.90645438
29MP0000371_diluted_coat_color1.85110869
30MP0010234_abnormal_vibrissa_follicle1.82741206
31MP0002249_abnormal_larynx_morphology1.70132435
32MP0005620_abnormal_muscle_contractility1.68325291
33MP0003705_abnormal_hypodermis_morpholog1.58652039
34MP0002332_abnormal_exercise_endurance1.56084803
35MP0004270_analgesia1.50143371
36MP0000470_abnormal_stomach_morphology1.45998564
37MP0005666_abnormal_adipose_tissue1.44190512
38MP0005330_cardiomyopathy1.37358685
39MP0006036_abnormal_mitochondrial_physio1.32433340
40MP0005266_abnormal_metabolism1.29833502
41MP0001879_abnormal_lymphatic_vessel1.28598759
42MP0000579_abnormal_nail_morphology1.25667395
43MP0003806_abnormal_nucleotide_metabolis1.24251310
44MP0002972_abnormal_cardiac_muscle1.21865986
45MP0002127_abnormal_cardiovascular_syste1.14759051
46MP0010771_integument_phenotype1.12541521
47MP0001216_abnormal_epidermal_layer1.08943380
48MP0004084_abnormal_cardiac_muscle1.08340523
49MP0004947_skin_inflammation1.03292761
50MP0000049_abnormal_middle_ear0.94760707
51MP0002108_abnormal_muscle_morphology0.92869053
52MP0002075_abnormal_coat/hair_pigmentati0.92328329
53MP0005375_adipose_tissue_phenotype0.91124676
54MP0004233_abnormal_muscle_weight0.90140593
55MP0002971_abnormal_brown_adipose0.88883379
56MP0003195_calcinosis0.88159430
57MP0005451_abnormal_body_composition0.86902553
58MP0003656_abnormal_erythrocyte_physiolo0.83165210
59MP0004484_altered_response_of0.80744445
60MP0003453_abnormal_keratinocyte_physiol0.80689208
61MP0004215_abnormal_myocardial_fiber0.79785908
62MP0000647_abnormal_sebaceous_gland0.77859061
63MP0004043_abnormal_pH_regulation0.75348388
64MP0005385_cardiovascular_system_phenoty0.74377816
65MP0001544_abnormal_cardiovascular_syste0.74377816
66MP0001299_abnormal_eye_distance/0.73094437
67MP0001191_abnormal_skin_condition0.72142516
68MP0002909_abnormal_adrenal_gland0.70354841
69MP0000372_irregular_coat_pigmentation0.68300318
70MP0002139_abnormal_hepatobiliary_system0.68071819
71MP0003221_abnormal_cardiomyocyte_apopto0.65053682
72MP0003329_amyloid_beta_deposits0.64642498
73MP0003950_abnormal_plasma_membrane0.64481529
74MP0009250_abnormal_appendicular_skeleto0.63350702
75MP0000367_abnormal_coat/_hair0.61971290
76MP0001346_abnormal_lacrimal_gland0.61808157
77MP0010630_abnormal_cardiac_muscle0.61492971
78MP0000427_abnormal_hair_cycle0.60678408
79MP0003566_abnormal_cell_adhesion0.60000367
80MP0009931_abnormal_skin_appearance0.59664269
81MP0006138_congestive_heart_failure0.57202791
82MP0000613_abnormal_salivary_gland0.56655907
83MP0000681_abnormal_thyroid_gland0.56539439
84MP0004858_abnormal_nervous_system0.56325628
85MP0008569_lethality_at_weaning0.54545957
86MP0001186_pigmentation_phenotype0.53446626
87MP0003755_abnormal_palate_morphology0.53157677
88MP0000343_altered_response_to0.52435945
89MP0008961_abnormal_basal_metabolism0.50145980
90MP0002060_abnormal_skin_morphology0.50018031
91MP0001177_atelectasis0.48703685
92MP0005319_abnormal_enzyme/_coenzyme0.48109229
93MP0005085_abnormal_gallbladder_physiolo0.47284130
94MP0003137_abnormal_impulse_conducting0.46500354
95MP0004859_abnormal_synaptic_plasticity0.45996377
96MP0003075_altered_response_to0.43077918
97MP0008775_abnormal_heart_ventricle0.40996950
98MP0003045_fibrosis0.40585567
99MP0002177_abnormal_outer_ear0.40489009
100MP0005165_increased_susceptibility_to0.38394330

Predicted human phenotypes

RankGene SetZ-score
1Distal arthrogryposis (HP:0005684)6.55337646
2Muscle fiber inclusion bodies (HP:0100299)6.44509006
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.42764700
4Exercise-induced myalgia (HP:0003738)6.23808670
5Nemaline bodies (HP:0003798)5.74788140
6Round ear (HP:0100830)5.38877957
7Ulnar deviation of the wrist (HP:0003049)5.29991129
8Exercise-induced muscle cramps (HP:0003710)4.92800008
9Type 1 muscle fiber predominance (HP:0003803)4.88583173
10Muscle hypertrophy of the lower extremities (HP:0008968)4.81508207
11Increased connective tissue (HP:0009025)4.79659632
12Absent phalangeal crease (HP:0006109)4.77293195
13Myopathic facies (HP:0002058)4.68405711
14Calf muscle hypertrophy (HP:0008981)4.66337711
15Difficulty running (HP:0009046)4.66004428
16Increased IgE level (HP:0003212)4.65717699
17Calcaneovalgus deformity (HP:0001848)4.56197537
18Myoglobinuria (HP:0002913)4.32673568
19Autoimmune thrombocytopenia (HP:0001973)4.24872547
20Muscle fiber splitting (HP:0003555)4.24101156
21Unilateral renal agenesis (HP:0000122)4.18338134
22Deformed tarsal bones (HP:0008119)4.05224091
23Hyporeflexia of lower limbs (HP:0002600)3.99107570
24Abnormal finger flexion creases (HP:0006143)3.94671234
25Rimmed vacuoles (HP:0003805)3.83343124
26Increased variability in muscle fiber diameter (HP:0003557)3.59820318
27Mesangial abnormality (HP:0001966)3.53643205
28Congenital malformation of the right heart (HP:0011723)3.44572767
29Double outlet right ventricle (HP:0001719)3.44572767
30Abnormality of skeletal muscle fiber size (HP:0012084)3.40742161
31Autoimmune hemolytic anemia (HP:0001890)3.40414653
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34943307
33Right ventricular cardiomyopathy (HP:0011663)3.32520986
34Cholelithiasis (HP:0001081)3.26387975
35Abnormality of the aortic arch (HP:0012303)3.22728509
36Distal lower limb muscle weakness (HP:0009053)3.22332228
37Abnormality of the calf musculature (HP:0001430)3.14407415
38Muscle stiffness (HP:0003552)3.08597186
39Myotonia (HP:0002486)3.06198488
40EMG: myopathic abnormalities (HP:0003458)3.03577847
41Abnormality of the parathyroid morphology (HP:0011766)3.02843470
42Cupped ribs (HP:0000887)3.01719510
43Paralysis (HP:0003470)2.98685667
44Areflexia of lower limbs (HP:0002522)2.98359014
45Congenital ichthyosiform erythroderma (HP:0007431)2.98085312
46Abnormal gallbladder morphology (HP:0012437)2.98032765
47Distal lower limb amyotrophy (HP:0008944)2.90005594
48Abnormality of the calcaneus (HP:0008364)2.85048378
49Hypoplastic ischia (HP:0003175)2.78529504
50Rhabdomyolysis (HP:0003201)2.78325021
51Hyperthyroidism (HP:0000836)2.75217859
52Neck muscle weakness (HP:0000467)2.73370589
53B lymphocytopenia (HP:0010976)2.68122221
54Abnormality of B cell number (HP:0010975)2.68122221
55Difficulty climbing stairs (HP:0003551)2.65941767
56Facial diplegia (HP:0001349)2.54606043
57Tetany (HP:0001281)2.50548893
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44460215
59Abnormality of the ischium (HP:0003174)2.41794234
60Short palpebral fissure (HP:0012745)2.30754109
61Lower limb amyotrophy (HP:0007210)2.29888515
62Frequent falls (HP:0002359)2.27515223
63Hypoplastic left heart (HP:0004383)2.25101074
64Thyroiditis (HP:0100646)2.10951086
65Severe combined immunodeficiency (HP:0004430)2.09656624
66Shoulder girdle muscle weakness (HP:0003547)2.01116997
67Oral leukoplakia (HP:0002745)11.8136457
68Amblyopia (HP:0000646)1.99456513
69Scapular winging (HP:0003691)1.98755950
70Delusions (HP:0000746)1.97757721
71Pelvic girdle muscle weakness (HP:0003749)1.94610315
72Ectropion (HP:0000656)1.89515706
73Abnormality of the gallbladder (HP:0005264)1.88273503
74Wrist flexion contracture (HP:0001239)1.88252894
75Ulnar deviation of finger (HP:0009465)1.87622394
76Foot dorsiflexor weakness (HP:0009027)1.87155677
77Abnormality of the hip-girdle musculature (HP:0001445)1.85390241
78Abnormality of the musculature of the pelvis (HP:0001469)1.85390241
79Long clavicles (HP:0000890)1.84649931
80Nasal speech (HP:0001611)1.83681644
81Hyperkalemia (HP:0002153)1.83109113
82Seborrheic dermatitis (HP:0001051)1.80924123
83Muscular dystrophy (HP:0003560)1.80273279
84Combined immunodeficiency (HP:0005387)1.77494239
85Exotropia (HP:0000577)1.77490983
86Gangrene (HP:0100758)1.77095549
87Hypertensive crisis (HP:0100735)1.75675881
88Palmoplantar keratoderma (HP:0000982)1.75163933
89Gout (HP:0001997)1.70243477
90Achilles tendon contracture (HP:0001771)1.69598033
91Metatarsus adductus (HP:0001840)1.68884513
92Abnormality of the foot musculature (HP:0001436)1.67898762
93Hypoplastic heart (HP:0001961)1.66902354
94Woolly hair (HP:0002224)1.66011906
95Corneal erosion (HP:0200020)1.64137763
96Abnormality of the shoulder girdle musculature (HP:0001435)1.62921517
97Malignant hyperthermia (HP:0002047)1.62912628
98Abnormality of the Achilles tendon (HP:0005109)1.62262156
99Proximal amyotrophy (HP:0007126)1.57240348
100Abnormality of nail color (HP:0100643)1.56545433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.90908289
2OBSCN3.83514715
3PHKG22.97779570
4PHKG12.97779570
5NEK12.93441712
6TRIB32.64940316
7PINK12.58935292
8PDK32.25616107
9PDK42.25616107
10MAP2K32.21507456
11TTN10.9288154
12MAPKAPK31.86251928
13BCKDK1.65811428
14PDK21.63727689
15DMPK1.57100434
16TAOK11.48521398
17NME11.45341153
18MAP3K71.25603300
19MAP2K41.20870302
20MAPK121.19349798
21PKN21.17486391
22KSR21.15342390
23MAP3K61.02189978
24MAP3K30.91968869
25FER0.87861173
26ERN10.87428510
27ERBB30.85220640
28DYRK1B0.83826493
29MAP2K60.80589129
30LATS20.78532158
31MAPK110.72161753
32EPHB10.71258268
33PAK60.69338042
34LRRK20.69239186
35LATS10.65643285
36CAMK2A0.64240170
37MAP3K90.63080682
38PRKD10.61833184
39RPS6KB20.60354720
40WNK40.56048111
41MUSK0.55187955
42MAP3K110.54135413
43LIMK10.54070300
44RIPK10.51965615
45PTK60.48226630
46MAP3K20.47899975
47SGK10.44453975
48PIK3CA0.44157731
49DDR20.42784030
50TRPM70.41514595
51CAMK2G0.39167551
52MAP3K10.38523091
53EEF2K0.37362913
54MAP2K10.36219375
55PRKAA20.31687418
56PRKCH0.30810803
57RET0.30638659
58PDPK10.29273771
59ROCK20.28137173
60DYRK30.26710808
61WNK10.26231804
62NTRK10.25545455
63EPHA30.25536078
64PDK10.25449513
65BMX0.25369389
66TAOK20.25194433
67PKN10.24255665
68PRKACA0.24242215
69MAP3K80.23536153
70RPS6KA30.23504861
71STK100.23034220
72ILK0.22753210
73ROCK10.22297444
74PAK30.21937218
75AKT20.20342268
76MOS0.19265296
77PRKG10.19257493
78SGK30.19113778
79MAPK40.18336462
80PDGFRA0.18076258
81MAPKAPK50.18063084
82TIE10.17675042
83PRKACB0.17165906
84PRKACG0.17164428
85JAK20.15013324
86MAPKAPK20.14911828
87MARK10.14823760
88EPHA40.14486890
89NTRK30.14482522
90CDK50.14152295
91ERBB40.12122065
92SGK2230.11668996
93SGK4940.11668996
94KSR10.11591828
95PRKD30.11113291
96BMPR20.11011413
97NEK90.10890908
98EPHB20.10737993
99SCYL20.10332633
100CDK190.09600103

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049704.45196886
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.43351784
3Phenylalanine metabolism_Homo sapiens_hsa003604.12926026
4Fat digestion and absorption_Homo sapiens_hsa049754.08243164
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.47663985
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.16612966
7Glycerolipid metabolism_Homo sapiens_hsa005612.72537203
8Histidine metabolism_Homo sapiens_hsa003402.66236529
9Tyrosine metabolism_Homo sapiens_hsa003502.25340900
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.22490039
11beta-Alanine metabolism_Homo sapiens_hsa004102.07035439
12Fatty acid degradation_Homo sapiens_hsa000711.86573643
13Arginine biosynthesis_Homo sapiens_hsa002201.81727143
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72099582
15Carbon metabolism_Homo sapiens_hsa012001.68332828
16Propanoate metabolism_Homo sapiens_hsa006401.67476778
17Cardiac muscle contraction_Homo sapiens_hsa042601.50494297
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49491132
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45951073
20Alzheimers disease_Homo sapiens_hsa050101.45829465
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37395287
22Olfactory transduction_Homo sapiens_hsa047401.35670578
23Parkinsons disease_Homo sapiens_hsa050121.33277897
24Chemical carcinogenesis_Homo sapiens_hsa052041.32529971
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32330217
26Glucagon signaling pathway_Homo sapiens_hsa049221.27394141
27Biosynthesis of amino acids_Homo sapiens_hsa012301.24406642
28Oxidative phosphorylation_Homo sapiens_hsa001901.24139854
29Pyruvate metabolism_Homo sapiens_hsa006201.22170641
30Starch and sucrose metabolism_Homo sapiens_hsa005001.17350930
31Fatty acid metabolism_Homo sapiens_hsa012121.15767348
32Nitrogen metabolism_Homo sapiens_hsa009101.15379243
33Dilated cardiomyopathy_Homo sapiens_hsa054141.14363834
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11919605
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10506331
36Phototransduction_Homo sapiens_hsa047441.07621517
37GnRH signaling pathway_Homo sapiens_hsa049120.97189185
38Renin secretion_Homo sapiens_hsa049240.94477384
39Gastric acid secretion_Homo sapiens_hsa049710.94104797
40Insulin signaling pathway_Homo sapiens_hsa049100.87034840
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86128382
42Oxytocin signaling pathway_Homo sapiens_hsa049210.86106854
43Arginine and proline metabolism_Homo sapiens_hsa003300.84412167
44Butanoate metabolism_Homo sapiens_hsa006500.81637848
45Circadian entrainment_Homo sapiens_hsa047130.81601686
46Long-term potentiation_Homo sapiens_hsa047200.78128599
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77336969
48Arachidonic acid metabolism_Homo sapiens_hsa005900.76949321
49Calcium signaling pathway_Homo sapiens_hsa040200.74197080
50Insulin resistance_Homo sapiens_hsa049310.70559375
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.70290005
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69141681
53Amphetamine addiction_Homo sapiens_hsa050310.62181668
54Tryptophan metabolism_Homo sapiens_hsa003800.61790406
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61113499
56Fatty acid elongation_Homo sapiens_hsa000620.60056609
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59739305
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59425088
59VEGF signaling pathway_Homo sapiens_hsa043700.58459827
60Sulfur metabolism_Homo sapiens_hsa009200.57785356
61Glioma_Homo sapiens_hsa052140.57526460
62PPAR signaling pathway_Homo sapiens_hsa033200.55439715
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54154229
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53795745
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.52619925
66Melanogenesis_Homo sapiens_hsa049160.50006375
67Huntingtons disease_Homo sapiens_hsa050160.49946983
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49808782
69Linoleic acid metabolism_Homo sapiens_hsa005910.49753090
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.46685027
71Long-term depression_Homo sapiens_hsa047300.42517952
72Pertussis_Homo sapiens_hsa051330.40994144
73Estrogen signaling pathway_Homo sapiens_hsa049150.40377479
74AMPK signaling pathway_Homo sapiens_hsa041520.37920069
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.37865134
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35544093
77Serotonergic synapse_Homo sapiens_hsa047260.35226722
78Galactose metabolism_Homo sapiens_hsa000520.34576582
79Tight junction_Homo sapiens_hsa045300.31455272
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.30511833
81Dopaminergic synapse_Homo sapiens_hsa047280.29800741
82Fructose and mannose metabolism_Homo sapiens_hsa000510.29056036
83Fatty acid biosynthesis_Homo sapiens_hsa000610.26936460
84Bile secretion_Homo sapiens_hsa049760.26442022
85Primary immunodeficiency_Homo sapiens_hsa053400.24910147
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24465591
87Focal adhesion_Homo sapiens_hsa045100.22905430
88Ovarian steroidogenesis_Homo sapiens_hsa049130.18181701
89Metabolic pathways_Homo sapiens_hsa011000.18168426
90Pentose phosphate pathway_Homo sapiens_hsa000300.17139041
91Type II diabetes mellitus_Homo sapiens_hsa049300.16378882
92Peroxisome_Homo sapiens_hsa041460.16357137
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.14780621
94Platelet activation_Homo sapiens_hsa046110.14028315
95Proteoglycans in cancer_Homo sapiens_hsa052050.13193695
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12484711
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12424530
98MAPK signaling pathway_Homo sapiens_hsa040100.10708860
99Cholinergic synapse_Homo sapiens_hsa047250.10642835
100GABAergic synapse_Homo sapiens_hsa047270.10434910

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