KRT77

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingoid metabolic process (GO:0046519)9.92488706
2keratinization (GO:0031424)9.14968486
3long-chain fatty acid biosynthetic process (GO:0042759)8.80772418
4sphingosine metabolic process (GO:0006670)8.60176473
5keratinocyte proliferation (GO:0043616)8.39418979
6keratinocyte differentiation (GO:0030216)8.24327432
7diol metabolic process (GO:0034311)7.70489493
8multicellular organismal water homeostasis (GO:0050891)7.36456338
9linoleic acid metabolic process (GO:0043651)6.75885026
10gap junction assembly (GO:0016264)6.72849343
11glucosamine-containing compound catabolic process (GO:1901072)6.64505651
12epidermal cell differentiation (GO:0009913)6.24146378
13water homeostasis (GO:0030104)6.19690521
14endothelium development (GO:0003158)6.06000343
15regulation of ruffle assembly (GO:1900027)5.90661569
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.89892096
17fatty acid elongation (GO:0030497)5.78852364
18regulation of phospholipase A2 activity (GO:0032429)5.72171676
19positive regulation of interleukin-8 secretion (GO:2000484)5.67462849
20lateral sprouting from an epithelium (GO:0060601)5.60802572
21polarized epithelial cell differentiation (GO:0030859)5.60309141
22negative regulation of cardiac muscle tissue growth (GO:0055022)5.57752963
23negative regulation of heart growth (GO:0061117)5.57752963
24interferon-gamma secretion (GO:0072643)5.53906617
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.50339227
26lipoxygenase pathway (GO:0019372)5.49695009
27adenine nucleotide transport (GO:0051503)5.41821125
28purine ribonucleotide transport (GO:0015868)5.41695830
29peptide cross-linking (GO:0018149)5.38613510
30regulation of chemokine secretion (GO:0090196)5.35835202
31atrial cardiac muscle cell action potential (GO:0086014)5.22753277
32epithelial cell differentiation involved in prostate gland development (GO:0060742)5.06985562
33epidermis development (GO:0008544)5.02535682
34skeletal muscle tissue regeneration (GO:0043403)4.94159780
35hair follicle morphogenesis (GO:0031069)4.93332106
36cyclooxygenase pathway (GO:0019371)4.83897612
37regulation of cell proliferation involved in kidney development (GO:1901722)4.82759642
38regulation of tight junction assembly (GO:2000810)4.81190813
39positive regulation of chemokine secretion (GO:0090197)4.66412665
40intermediate filament organization (GO:0045109)4.49399384
41epithelial cell maturation (GO:0002070)4.40933633
42long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.40384262
43prostaglandin biosynthetic process (GO:0001516)4.39125193
44prostanoid biosynthetic process (GO:0046457)4.39125193
45intestinal epithelial cell development (GO:0060576)4.32587814
46cardiolipin metabolic process (GO:0032048)4.28195614
47hair cycle (GO:0042633)4.28111376
48molting cycle (GO:0042303)4.28111376
49phosphatidylinositol acyl-chain remodeling (GO:0036149)4.24743282
50renal system process involved in regulation of blood volume (GO:0001977)4.23581086
51intermediate filament-based process (GO:0045103)4.22968182
52regulation of keratinocyte differentiation (GO:0045616)4.22901498
53purine nucleotide transport (GO:0015865)4.19865958
54viral transcription (GO:0019083)4.17924627
55negative regulation of stress fiber assembly (GO:0051497)4.10684533
56regulation of interleukin-8 secretion (GO:2000482)4.10357209
57keratinocyte development (GO:0003334)4.09331392
58hemidesmosome assembly (GO:0031581)4.09228406
59retinal metabolic process (GO:0042574)4.05355320
60regulation of transforming growth factor beta1 production (GO:0032908)3.94968281
61translational termination (GO:0006415)3.91221575
62detection of bacterium (GO:0016045)3.87507828
63chemical homeostasis within a tissue (GO:0048875)3.85349275
64molting cycle process (GO:0022404)3.84393085
65hair cycle process (GO:0022405)3.84393085
66regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.79624656
67ectoderm development (GO:0007398)3.77072770
68regulation of hypersensitivity (GO:0002883)3.69655816
69sphingolipid biosynthetic process (GO:0030148)3.68944374
70phospholipid scrambling (GO:0017121)3.67507284
71fatty-acyl-CoA metabolic process (GO:0035337)3.66505933
72phosphatidylserine acyl-chain remodeling (GO:0036150)3.66061262
73gland morphogenesis (GO:0022612)3.59795931
74positive regulation of glomerulus development (GO:0090193)3.59083333
75skin morphogenesis (GO:0043589)3.57834702
76G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.56435089
77negative regulation of cardiac muscle tissue development (GO:0055026)3.54956070
78regulation of cholesterol homeostasis (GO:2000188)3.54628550
79prostaglandin metabolic process (GO:0006693)3.54617012
80prostanoid metabolic process (GO:0006692)3.54617012
81primary alcohol catabolic process (GO:0034310)3.54200295
82imidazole-containing compound metabolic process (GO:0052803)3.53351420
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53204798
84unsaturated fatty acid biosynthetic process (GO:0006636)3.51280387
85chemosensory behavior (GO:0007635)3.50670641
86positive regulation of mitochondrial membrane permeability (GO:0035794)3.48791574
87one-carbon compound transport (GO:0019755)3.46214225
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.44943329
89ceramide catabolic process (GO:0046514)3.44437865
90ribosomal small subunit biogenesis (GO:0042274)3.42000499
91negative regulation of kidney development (GO:0090185)3.41208687
92amino sugar catabolic process (GO:0046348)3.38953645
93chronic inflammatory response (GO:0002544)3.35434405
94polyol transport (GO:0015791)3.33275208
95phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.31978085
96eyelid development in camera-type eye (GO:0061029)3.29916503
97positive regulation of vesicle fusion (GO:0031340)3.29385370
98phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.24857804
99detection of other organism (GO:0098543)3.22280718
100epithelium development (GO:0060429)3.21121229
101renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.14047157
102phosphatidylglycerol metabolic process (GO:0046471)3.12492270
103viral life cycle (GO:0019058)3.10392671
104nucleoside transport (GO:0015858)3.09924387
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09181712
106negative regulation of interferon-gamma production (GO:0032689)3.08951984
107negative regulation of interleukin-2 production (GO:0032703)3.08274880
108protein targeting to ER (GO:0045047)3.06954001
109retinol metabolic process (GO:0042572)3.06189829
110very long-chain fatty acid metabolic process (GO:0000038)3.06188014
111establishment of planar polarity (GO:0001736)3.05789172
112establishment of tissue polarity (GO:0007164)3.05789172
113regulation of neuron projection regeneration (GO:0070570)3.05229753
114regulation of axon regeneration (GO:0048679)3.05229753
115hair follicle development (GO:0001942)3.05120360
116cotranslational protein targeting to membrane (GO:0006613)3.04494426
117translational elongation (GO:0006414)3.03760021
118establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00976165
119negative regulation of membrane potential (GO:0045837)3.00911055
120regulation of keratinocyte proliferation (GO:0010837)3.00353467
121positive regulation of interleukin-4 production (GO:0032753)2.98669886
122negative regulation of lipase activity (GO:0060192)2.97471466
123cellular protein complex disassembly (GO:0043624)2.95486765
124negative regulation of acute inflammatory response (GO:0002674)2.93815726
125regulation of epidermis development (GO:0045682)2.93515176
126negative regulation of keratinocyte proliferation (GO:0010839)2.93411948
127cardiac right ventricle morphogenesis (GO:0003215)2.92136329
128phosphatidylcholine acyl-chain remodeling (GO:0036151)2.91449433
129arachidonic acid metabolic process (GO:0019369)2.90672107
130negative regulation of actin filament bundle assembly (GO:0032232)2.89657821
131cellular response to interferon-alpha (GO:0035457)2.89596697
132cellular response to calcium ion (GO:0071277)2.88834197
133protein localization to endoplasmic reticulum (GO:0070972)2.86711183
134regulation of epidermal cell differentiation (GO:0045604)2.85810407
135negative regulation of epidermal cell differentiation (GO:0045605)2.85650511
136atrioventricular valve morphogenesis (GO:0003181)2.83603257
137intermediate filament cytoskeleton organization (GO:0045104)2.82867897
138regulation of glomerular filtration (GO:0003093)2.82658587
139long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.82498273
140cell-cell junction assembly (GO:0007043)2.79440532
141phosphatidylserine metabolic process (GO:0006658)2.75211336
142magnesium ion transport (GO:0015693)2.75205397
143cellular response to arsenic-containing substance (GO:0071243)2.74184513
144genitalia morphogenesis (GO:0035112)2.73160564
145cardiac muscle cell action potential involved in contraction (GO:0086002)2.71370673
146positive regulation of keratinocyte differentiation (GO:0045618)2.69583456
147cell communication by electrical coupling (GO:0010644)2.69549222
148cardiac muscle cell action potential (GO:0086001)2.65287798
149sympathetic nervous system development (GO:0048485)2.65164286
150fatty-acyl-CoA biosynthetic process (GO:0046949)2.63669733
151positive regulation of epidermal cell differentiation (GO:0045606)2.63557416
152phospholipid catabolic process (GO:0009395)2.62794601
153fibrinolysis (GO:0042730)2.59129432
154cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.57120022
155epithelial cell proliferation (GO:0050673)2.53582531
156adult heart development (GO:0007512)2.53121241
157lung lobe morphogenesis (GO:0060463)2.52039327
158T-helper cell differentiation (GO:0042093)2.49681244
159CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49681244
160desmosome organization (GO:0002934)16.7444996
161establishment of skin barrier (GO:0061436)11.6112665
162regulation of water loss via skin (GO:0033561)10.7836739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.15563163
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.14685668
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.68405809
4ZNF263_19887448_ChIP-Seq_K562_Human2.66780102
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23704819
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14567506
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.10864276
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.05864407
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.04257004
10TP63_17297297_ChIP-ChIP_HaCaT_Human16.3093104
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93731921
12SRY_22984422_ChIP-ChIP_TESTIS_Rat1.86249730
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84759041
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84759041
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.84031716
16EGR1_19032775_ChIP-ChIP_M12_Human1.69109130
17TCF4_18268006_ChIP-ChIP_LS174T_Human1.65040766
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61140709
19NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56705523
20NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56705523
21SOX2_20726797_ChIP-Seq_SW620_Human1.47593030
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46742058
23TP63_23658742_ChIP-Seq_EP156T_Human1.46715968
24GATA1_22025678_ChIP-Seq_K562_Human1.46578025
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44834915
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44775750
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43538834
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31648860
29FUS_26573619_Chip-Seq_HEK293_Human1.30724567
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.30638768
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28292627
32* TP63_22573176_ChIP-Seq_HFKS_Human1.28220445
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28098125
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.27788878
35CJUN_26792858_Chip-Seq_BT549_Human1.22084220
36RXR_22108803_ChIP-Seq_LS180_Human1.18991833
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16135391
38GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13433969
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13045541
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09240427
41KLF5_25053715_ChIP-Seq_YYC3_Human1.09233242
42AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07927722
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06436951
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06436214
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.05788172
46CEBPB_22108803_ChIP-Seq_LS180_Human1.05307069
47TP53_18474530_ChIP-ChIP_U2OS_Human1.03617406
48GATA4_25053715_ChIP-Seq_YYC3_Human1.03465454
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01944613
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01295893
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01218568
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01184248
53AR_21572438_ChIP-Seq_LNCaP_Human1.00481193
54GATA3_24758297_ChIP-Seq_MCF-7_Human0.98850628
55AHR_22903824_ChIP-Seq_MCF-7_Human0.98242957
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.97520134
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95883028
58BCAT_22108803_ChIP-Seq_LS180_Human0.94150087
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93353632
60TP53_20018659_ChIP-ChIP_R1E_Mouse0.92876037
61ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91512053
62CDX2_22108803_ChIP-Seq_LS180_Human0.91413675
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90736826
64ATF3_27146783_Chip-Seq_COLON_Human0.90421305
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90291935
66POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89897694
67SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89683727
68RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89491495
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89116983
70PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88801807
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87718375
72RACK7_27058665_Chip-Seq_MCF-7_Human0.86911502
73TP53_16413492_ChIP-PET_HCT116_Human0.86472317
74TCF4_22108803_ChIP-Seq_LS180_Human0.84185310
75SA1_27219007_Chip-Seq_Bcells_Human0.84022704
76SA1_27219007_Chip-Seq_ERYTHROID_Human0.82382850
77GATA6_25053715_ChIP-Seq_YYC3_Human0.81258245
78EZH2_27304074_Chip-Seq_ESCs_Mouse0.80659311
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78754260
80FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78062851
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.78040186
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77923454
83UBF1/2_26484160_Chip-Seq_HMECs_Human0.77539905
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77241356
85FOXA1_25552417_ChIP-Seq_VCAP_Human0.77173186
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.77130142
87TAF15_26573619_Chip-Seq_HEK293_Human0.76746572
88CLOCK_20551151_ChIP-Seq_293T_Human0.75910676
89EED_16625203_ChIP-ChIP_MESCs_Mouse0.75056908
90FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74463612
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74405115
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74322758
93P53_21459846_ChIP-Seq_SAOS-2_Human0.73879102
94CTCF_27219007_Chip-Seq_Bcells_Human0.73711375
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72346474
96RUNX_20019798_ChIP-Seq_JUKART_Human0.72217519
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.71870195
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70886238
99LXR_22292898_ChIP-Seq_THP-1_Human0.70280298
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70041389
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.69671899
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69370329
103EZH2_27294783_Chip-Seq_ESCs_Mouse0.69130257
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.67676205
105LXR_22158963_ChIP-Seq_LIVER_Mouse0.67396497
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67356680
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.67163762
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66743241
109* SMAD3_21741376_ChIP-Seq_EPCs_Human0.66578963
110GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.66351275
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.66341898
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.66331236
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66312808
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.65891187
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.65641524
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65451662
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.65449087
118RBPJ_21746931_ChIP-Seq_IB4_Human0.65358831
119SCL_19346495_ChIP-Seq_HPC-7_Human0.64847810
120ERG_20517297_ChIP-Seq_VCAP_Human0.64736769
121TBX3_20139965_ChIP-Seq_MESCs_Mouse0.64591343
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64088102
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.63411451
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.63330217
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.63134676
126TBL1_22424771_ChIP-Seq_293T_Human0.63051963
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.63049406
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.63049406
129FOXA1_27270436_Chip-Seq_PROSTATE_Human0.62795490
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.62795490
131VDR_24787735_ChIP-Seq_THP-1_Human0.62655630
132HNFA_21074721_ChIP-Seq_CACO-2_Human0.62555175
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.61758852
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61558355
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.61545560
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60652273
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.59937492
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59294654
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.59203880
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.58944992
141GATA3_21867929_ChIP-Seq_TH1_Mouse0.58814567
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.57689826
143CBX2_22325352_ChIP-Seq_293T-Rex_Human0.57315734
144JARID2_20064375_ChIP-Seq_MESCs_Mouse0.57068719
145JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56827493
146SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.56546941
147SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.55848093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.65617141
2MP0003941_abnormal_skin_development6.21314539
3MP0005275_abnormal_skin_tensile5.81686815
4MP0005501_abnormal_skin_physiology5.43956168
5MP0010234_abnormal_vibrissa_follicle5.37036081
6MP0004381_abnormal_hair_follicle3.79499115
7MP0001216_abnormal_epidermal_layer3.72706514
8MP0001188_hyperpigmentation3.64248593
9MP0002060_abnormal_skin_morphology3.54756887
10MP0003453_abnormal_keratinocyte_physiol3.41526941
11MP0010771_integument_phenotype3.36207896
12MP0000566_synostosis3.09272871
13MP0002254_reproductive_system_inflammat2.86252837
14MP0005451_abnormal_body_composition2.80346292
15MP0002098_abnormal_vibrissa_morphology2.70582050
16MP0004947_skin_inflammation2.59721863
17MP0010678_abnormal_skin_adnexa2.59554113
18MP0000383_abnormal_hair_follicle2.58193900
19MP0000467_abnormal_esophagus_morphology2.35185934
20MP0000647_abnormal_sebaceous_gland2.33227291
21MP0000579_abnormal_nail_morphology2.19260073
22MP0000377_abnormal_hair_follicle2.16167505
23MP0002009_preneoplasia2.01413094
24MP0000015_abnormal_ear_pigmentation1.98754594
25MP0005174_abnormal_tail_pigmentation1.97947941
26MP0004185_abnormal_adipocyte_glucose1.97269043
27MP0003566_abnormal_cell_adhesion1.92440912
28MP0001191_abnormal_skin_condition1.83573848
29MP0009931_abnormal_skin_appearance1.80397783
30MP0000427_abnormal_hair_cycle1.68605460
31MP0001346_abnormal_lacrimal_gland1.64319887
32MP0008004_abnormal_stomach_pH1.62541786
33MP0003705_abnormal_hypodermis_morpholog1.45466606
34MP0001243_abnormal_dermal_layer1.41372843
35MP0000367_abnormal_coat/_hair1.39873739
36MP0010352_gastrointestinal_tract_polyps1.35597412
37MP0001984_abnormal_olfaction1.33216930
38MP0001853_heart_inflammation1.25726567
39MP0003279_aneurysm1.25302098
40MP0000762_abnormal_tongue_morphology1.23911223
41MP0001542_abnormal_bone_strength1.19501024
42MP0003011_delayed_dark_adaptation1.18259608
43MP0005409_darkened_coat_color1.17681304
44MP0009379_abnormal_foot_pigmentation1.14593121
45MP0003191_abnormal_cellular_cholesterol1.13894445
46MP0001340_abnormal_eyelid_morphology1.06763051
47MP0001851_eye_inflammation0.93624275
48MP0000428_abnormal_craniofacial_morphol0.90058789
49MP0002006_tumorigenesis0.89195408
50MP0003436_decreased_susceptibility_to0.88756269
51MP0000465_gastrointestinal_hemorrhage0.87544242
52MP0004782_abnormal_surfactant_physiolog0.83064635
53MP0002877_abnormal_melanocyte_morpholog0.75829651
54MP0005503_abnormal_tendon_morphology0.72585280
55MP0005076_abnormal_cell_differentiation0.71991104
56MP0000750_abnormal_muscle_regeneration0.71389027
57MP0004019_abnormal_vitamin_homeostasis0.70707732
58MP0002166_altered_tumor_susceptibility0.69520648
59MP0009780_abnormal_chondrocyte_physiolo0.69265589
60MP0005023_abnormal_wound_healing0.68664547
61MP0000462_abnormal_digestive_system0.68124621
62MP0003763_abnormal_thymus_physiology0.66883249
63MP0000627_abnormal_mammary_gland0.65725935
64MP0002177_abnormal_outer_ear0.61639462
65MP0003690_abnormal_glial_cell0.61382011
66MP0009053_abnormal_anal_canal0.60794995
67MP0005075_abnormal_melanosome_morpholog0.60521618
68MP0005171_absent_coat_pigmentation0.59937247
69MP0005197_abnormal_uvea_morphology0.59078384
70MP0002148_abnormal_hypersensitivity_rea0.58668354
71MP0001784_abnormal_fluid_regulation0.57672592
72MP0008961_abnormal_basal_metabolism0.57105627
73MP0000516_abnormal_urinary_system0.57031509
74MP0005367_renal/urinary_system_phenotyp0.57031509
75MP0005666_abnormal_adipose_tissue0.56473255
76MP0002277_abnormal_respiratory_mucosa0.54285230
77MP0002233_abnormal_nose_morphology0.51225894
78MP0002090_abnormal_vision0.50183962
79MP0004264_abnormal_extraembryonic_tissu0.49636577
80MP0003638_abnormal_response/metabolism_0.49546169
81MP0004215_abnormal_myocardial_fiber0.48129692
82MP0004885_abnormal_endolymph0.47732581
83MP0002234_abnormal_pharynx_morphology0.44953864
84MP0001666_abnormal_nutrient_absorption0.44391030
85MP0008789_abnormal_olfactory_epithelium0.43589911
86MP0003950_abnormal_plasma_membrane0.42370930
87MP0005377_hearing/vestibular/ear_phenot0.42177195
88MP0003878_abnormal_ear_physiology0.42177195
89MP0010386_abnormal_urinary_bladder0.42042868
90MP0002111_abnormal_tail_morphology0.40766446
91MP0003300_gastrointestinal_ulcer0.40610511
92MP0003315_abnormal_perineum_morphology0.40509321
93MP0009672_abnormal_birth_weight0.40126518
94MP0000470_abnormal_stomach_morphology0.38228172
95MP0002998_abnormal_bone_remodeling0.38068432
96MP0000538_abnormal_urinary_bladder0.36248193
97MP0003329_amyloid_beta_deposits0.35437782
98MP0000372_irregular_coat_pigmentation0.34757076
99MP0004484_altered_response_of0.33077088
100MP0001177_atelectasis0.32967514
101MP0006054_spinal_hemorrhage0.32451707
102MP0001299_abnormal_eye_distance/0.32233398
103MP0003136_yellow_coat_color0.31236698
104MP0002092_abnormal_eye_morphology0.31060213
105MP0000049_abnormal_middle_ear0.30443565
106MP0005375_adipose_tissue_phenotype0.30377486
107MP0010030_abnormal_orbit_morphology0.30223533
108MP0008438_abnormal_cutaneous_collagen0.29947782
109MP0001881_abnormal_mammary_gland0.29769798
110MP0005394_taste/olfaction_phenotype0.29625939
111MP0005499_abnormal_olfactory_system0.29625939
112MP0003938_abnormal_ear_development0.29061245
113MP0001186_pigmentation_phenotype0.28920584
114MP0003718_maternal_effect0.28870227
115MP0000432_abnormal_head_morphology0.27482152
116MP0005508_abnormal_skeleton_morphology0.26913890
117MP0009384_cardiac_valve_regurgitation0.26771852
118MP0001440_abnormal_grooming_behavior0.26578309
119MP0001765_abnormal_ion_homeostasis0.26511537
120MP0004858_abnormal_nervous_system0.26215821
121MP0005595_abnormal_vascular_smooth0.26094586
122MP0006138_congestive_heart_failure0.26044044
123MP0002282_abnormal_trachea_morphology0.25895998
124MP0004510_myositis0.25545993
125MP0003828_pulmonary_edema0.25254854
126MP0002095_abnormal_skin_pigmentation0.25025181
127MP0002249_abnormal_larynx_morphology0.24967669
128MP0005083_abnormal_biliary_tract0.22982176
129MP0005193_abnormal_anterior_eye0.22930164
130MP0000537_abnormal_urethra_morphology0.21166813
131MP0004197_abnormal_fetal_growth/weight/0.20910878
132MP0000613_abnormal_salivary_gland0.20480324
133MP0003755_abnormal_palate_morphology0.20047106
134MP0005248_abnormal_Harderian_gland0.19877692
135MP0001533_abnormal_skeleton_physiology0.19087095
136MP0002736_abnormal_nociception_after0.17988007
137MP0003385_abnormal_body_wall0.17505077
138MP0005390_skeleton_phenotype0.17378427
139MP0005464_abnormal_platelet_physiology0.17173019
140MP0002081_perinatal_lethality0.16434418
141MP0003183_abnormal_peptide_metabolism0.16166960
142MP0005647_abnormal_sex_gland0.15617175

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.42140534
2Congenital ichthyosiform erythroderma (HP:0007431)8.52061080
3Hypotrichosis (HP:0001006)7.18551981
4Lip pit (HP:0100267)6.96294165
5Parakeratosis (HP:0001036)6.74150190
6Erythema (HP:0010783)6.71867173
7Right ventricular cardiomyopathy (HP:0011663)6.45498357
8Woolly hair (HP:0002224)6.41951557
9Erythroderma (HP:0001019)6.04452643
10Conjunctival hamartoma (HP:0100780)5.97101521
11Palmoplantar hyperkeratosis (HP:0000972)5.79806535
12Plantar hyperkeratosis (HP:0007556)5.55371927
13Palmar hyperkeratosis (HP:0010765)5.42680947
14Abnormality of the axillary hair (HP:0100134)5.36139711
15Abnormality of secondary sexual hair (HP:0009888)5.36139711
16Increased IgE level (HP:0003212)5.01999358
17Dry hair (HP:0011359)4.79036336
18Selective tooth agenesis (HP:0001592)4.67229026
19Ectropion (HP:0000656)4.60530127
20Alopecia of scalp (HP:0002293)4.53823797
21Corneal erosion (HP:0200020)4.38453030
22Popliteal pterygium (HP:0009756)4.25456816
23Gangrene (HP:0100758)4.21421426
24Short middle phalanx of the 5th finger (HP:0004220)4.17950068
25Hypohidrosis (HP:0000966)4.16315233
26Abnormality of hair growth rate (HP:0011363)3.95577428
27Slow-growing hair (HP:0002217)3.95577428
28Hyporeflexia of lower limbs (HP:0002600)3.89269307
29Abnormality of permanent molar morphology (HP:0011071)3.79650835
30Abnormality of the dental root (HP:0006486)3.79650835
31Taurodontia (HP:0000679)3.79650835
32Abnormality of nail color (HP:0100643)3.69887668
33Abnormal blistering of the skin (HP:0008066)3.66497638
34Pruritus (HP:0000989)3.63454927
35Onycholysis (HP:0001806)3.60989145
36Abnormality of molar (HP:0011077)3.56453140
37Abnormality of molar morphology (HP:0011070)3.56453140
38Long nose (HP:0003189)3.56382687
39Ventricular tachycardia (HP:0004756)3.52036847
40Palmoplantar keratoderma (HP:0000982)3.51678941
41Abnormality of the salivary glands (HP:0010286)3.50156385
42Absent eyelashes (HP:0000561)3.47250498
43Hamartoma of the eye (HP:0010568)3.44873559
44Sparse scalp hair (HP:0002209)3.44132088
45Curly hair (HP:0002212)3.39002961
46Abnormality of the dental pulp (HP:0006479)3.37428254
47Fragile nails (HP:0001808)3.34241786
48Tetraparesis (HP:0002273)3.26222496
49Distal lower limb muscle weakness (HP:0009053)3.23832508
50Pili torti (HP:0003777)3.09894762
51Natal tooth (HP:0000695)3.09836522
52Sparse eyelashes (HP:0000653)3.08628012
53Nasolacrimal duct obstruction (HP:0000579)3.05422616
54Advanced eruption of teeth (HP:0006288)3.02198307
55Hypoplastic labia majora (HP:0000059)2.97988761
56Eczematoid dermatitis (HP:0000976)2.95304978
57Areflexia of lower limbs (HP:0002522)2.88677586
58Acanthosis nigricans (HP:0000956)2.85794890
59Split foot (HP:0001839)2.82993973
60Abnormality of the columella (HP:0009929)2.73066853
61Abnormality of the labia majora (HP:0012881)2.70410654
62Broad alveolar ridges (HP:0000187)2.66889545
63Nail dystrophy (HP:0008404)2.61702199
64Dry skin (HP:0000958)2.61150743
65Septate vagina (HP:0001153)2.60782086
66Severe Myopia (HP:0011003)2.57683220
67Lack of skin elasticity (HP:0100679)2.54108025
68Mixed hearing impairment (HP:0000410)2.53598590
69Absent hair (HP:0002298)2.50727668
70Thick nail (HP:0001805)2.50629401
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.49638442
72Abnormality of the lacrimal duct (HP:0011481)2.49077760
73Ventricular fibrillation (HP:0001663)2.46722012
74Conical tooth (HP:0000698)2.46569582
75Congenital, generalized hypertrichosis (HP:0004540)2.41228696
76Milia (HP:0001056)2.40518675
77Abnormality of the gastric mucosa (HP:0004295)2.35944081
78Duplicated collecting system (HP:0000081)2.32992924
79Atrioventricular block (HP:0001678)2.32785954
80Abnormality of the nasolacrimal system (HP:0000614)2.29702830
81Depressed nasal tip (HP:0000437)2.29430781
82Xerostomia (HP:0000217)2.27264800
83Abnormality of cells of the erythroid lineage (HP:0012130)2.23978240
84Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.22454877
85Dehydration (HP:0001944)2.20078550
86Pterygium (HP:0001059)2.19245053
87Paralysis (HP:0003470)2.12117076
88Abnormal hemoglobin (HP:0011902)2.09845093
89Premature loss of primary teeth (HP:0006323)2.05656646
90Reticulocytopenia (HP:0001896)2.04732233
91Narrow nasal bridge (HP:0000446)2.04711792
92Short hallux (HP:0010109)2.03721277
93Fasciculations (HP:0002380)2.03428250
94Abnormal hair laboratory examination (HP:0003328)2.03113124
95Sensory axonal neuropathy (HP:0003390)2.02554038
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.01507194
97Hypoplastic left heart (HP:0004383)1.98415234
98Abnormality of the renal collecting system (HP:0004742)1.98152223
99Non-midline cleft lip (HP:0100335)1.97816987
100Hypoplasia of dental enamel (HP:0006297)1.96783618
101Fine hair (HP:0002213)1.96637747
102Ulnar claw (HP:0001178)1.93864604
103Labial hypoplasia (HP:0000066)1.93523942
104Anhidrosis (HP:0000970)1.92466234
105Concave nail (HP:0001598)1.90472499
106Stenosis of the external auditory canal (HP:0000402)1.89585220
107Abnormality of the alveolar ridges (HP:0006477)1.87475792
108Aplasia/Hypoplasia of the hallux (HP:0008362)1.85095313
109Oligodontia (HP:0000677)1.83631279
110Skin pits (HP:0100276)1.83214360
111Achilles tendon contracture (HP:0001771)1.82337136
112Abnormality of the phalanges of the 5th finger (HP:0004213)1.81644942
113Cutaneous syndactyly (HP:0012725)1.81104543
114Blepharitis (HP:0000498)1.81034420
115Ridged nail (HP:0001807)1.80667277
116Abnormality of incisor morphology (HP:0011063)1.79242857
117Short 5th finger (HP:0009237)1.78018641
118Hypoplasia of the uterus (HP:0000013)1.77012589
119Hypoplastic female external genitalia (HP:0012815)1.76338449
120Brittle hair (HP:0002299)1.76298875
121Neonatal death (HP:0003811)1.76216823
122Flared metaphyses (HP:0003015)1.76182449
123Macrocytic anemia (HP:0001972)1.74215176
124Median cleft lip (HP:0000161)1.73586804
125Hypoparathyroidism (HP:0000829)1.71841180
126Down-sloping shoulders (HP:0200021)1.71486402
127Craniofacial hyperostosis (HP:0004493)1.71008157
128Abnormal number of erythroid precursors (HP:0012131)1.70186458
129Abnormality of the Achilles tendon (HP:0005109)1.69678710
130Bifid scrotum (HP:0000048)1.69581487
131Sudden death (HP:0001699)1.67421743
132Sepsis (HP:0100806)1.66367146
133Abnormality of the distal phalanges of the toes (HP:0010182)1.65192655
134Hypergammaglobulinemia (HP:0010702)1.64969568
135Polygenic inheritance (HP:0010982)1.62316702
136Skin ulcer (HP:0200042)1.60403557
137Malignant hyperthermia (HP:0002047)1.57868471
138Aplasia/hypoplasia of the uterus (HP:0008684)1.56794999
139Hamartoma (HP:0010566)1.55139235
140Aplasia involving bones of the extremities (HP:0009825)1.52876212
141Aplasia involving bones of the upper limbs (HP:0009823)1.52876212
142Aplasia of the phalanges of the hand (HP:0009802)1.52876212
143Hypodontia (HP:0000668)1.51910151
144Pustule (HP:0200039)1.50589096
145Melanocytic nevus (HP:0000995)1.49855927
146Cutaneous finger syndactyly (HP:0010554)1.47847419
147Type I diabetes mellitus (HP:0100651)1.47463954
148Trismus (HP:0000211)1.47215908
149Intention tremor (HP:0002080)1.46503026
150Urticaria (HP:0001025)1.46345347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.77630183
2MST1R4.87576187
3MAP3K34.37135770
4MST43.92427366
5MAPK73.64601730
6FER3.03571510
7PIM22.91026051
8RPS6KB22.87064237
9MAP3K22.77878500
10FGFR12.71228375
11TESK12.53142042
12STK32.48755348
13TRPM72.13543170
14BLK2.13265453
15MAPKAPK51.92795518
16LIMK11.74279341
17STK241.73338929
18BRSK21.69283752
19MAP3K121.60413589
20KIT1.59554745
21RIPK41.57211806
22MET1.55216517
23FGFR21.45595911
24PIK3CG1.44516389
25NTRK21.43303652
26ERN11.40703670
27BCR1.39951070
28EEF2K1.38070819
29LATS11.37301475
30LRRK21.34475433
31STK101.33529188
32ERBB31.32025840
33DYRK1B1.31086159
34MAP3K111.30979894
35SGK2231.29889831
36SGK4941.29889831
37TAOK11.28946631
38EPHB21.27486324
39MAP3K141.23725816
40NLK1.18583030
41MAP2K61.17590225
42GRK71.14362251
43MAP3K91.12543222
44TGFBR21.11449918
45PTK61.09708562
46TAF11.08646601
47CDK191.07473460
48RPS6KB11.06772857
49NME21.02659971
50CDK61.01186969
51MKNK20.95616410
52IRAK30.93343285
53ITK0.92867090
54MAP2K40.87268489
55MAP3K50.86790318
56CDK30.85640851
57ICK0.83439452
58PRKCG0.82444925
59MAPKAPK20.82334104
60GRK10.81811601
61BMPR1B0.79610169
62RIPK10.79401746
63EPHA40.78636884
64SGK20.78154840
65TYRO30.77389136
66MAP3K10.76028566
67FGFR40.75764729
68TAOK30.74172056
69MAP3K70.74117859
70BRD40.71295011
71FGFR30.67237442
72PAK30.64807752
73STK38L0.62843686
74MAP3K60.62113948
75ADRBK10.62089240
76BRAF0.61485808
77RPS6KA40.61421749
78MINK10.60826520
79FRK0.58821824
80GRK50.58466459
81MOS0.56673527
82ILK0.56607399
83EIF2AK20.55684964
84MKNK10.55589178
85LATS20.54312894
86PRKAA20.53938461
87GSK3A0.53513324
88TTN0.53204046
89STK110.51011575
90IRAK10.50960133
91AKT30.50463880
92PRKD10.48730570
93PRKCI0.46834937
94SGK30.46280477
95SGK10.45549951
96EPHA20.45344963
97PRKCE0.43250570
98IGF1R0.42682100
99PKN10.41786058
100CAMKK20.39613687
101MAP2K30.38913832
102TNK20.38118240
103MAPK90.37947641
104IKBKB0.36772596
105CSNK1D0.34760968
106MAP2K10.34601837
107DMPK0.34262471
108YES10.32827476
109EPHA30.32638922
110SYK0.32568986
111IRAK20.31851563
112JAK20.31171901
113PRPF4B0.30926273
114MARK20.29285239
115OBSCN0.29090828
116MTOR0.29053447
117MAPK150.28502525
118MAPK40.28483072
119ABL10.27832288
120MAPK120.27250441
121TYK20.26325274
122CASK0.23152972
123IKBKE0.22879679
124SRC0.22555060
125TNIK0.22514081
126BMPR20.21879316
127CHUK0.21246202
128CSNK1E0.19624857
129PRKCA0.19243752
130DYRK30.18769695
131TRIB30.16768034
132TTK0.16541438
133HCK0.16521094
134TGFBR10.16220684
135MAP3K130.15514002
136RPS6KA20.15071595
137MAPK80.14435042
138NEK90.13376240
139MAPK100.12839797
140SIK10.12658602
141PTK20.12643262
142HIPK20.12284421
143GRK60.12144838
144MAPK30.11326358
145MAPK10.10093632

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006004.90090580
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.96120023
3Arachidonic acid metabolism_Homo sapiens_hsa005903.70358259
4Linoleic acid metabolism_Homo sapiens_hsa005913.52787235
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.43438459
6Ribosome_Homo sapiens_hsa030103.33286832
7Fatty acid elongation_Homo sapiens_hsa000623.12709050
8Circadian rhythm_Homo sapiens_hsa047102.87610203
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.79189646
10Caffeine metabolism_Homo sapiens_hsa002322.39818958
11Phenylalanine metabolism_Homo sapiens_hsa003602.27827299
12Ether lipid metabolism_Homo sapiens_hsa005652.20984118
13Histidine metabolism_Homo sapiens_hsa003402.10461881
14Retinol metabolism_Homo sapiens_hsa008301.98058380
15Staphylococcus aureus infection_Homo sapiens_hsa051501.78573662
16Sphingolipid signaling pathway_Homo sapiens_hsa040711.71578446
17Vitamin digestion and absorption_Homo sapiens_hsa049771.70753412
18VEGF signaling pathway_Homo sapiens_hsa043701.64308455
19Serotonergic synapse_Homo sapiens_hsa047261.51267277
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36027304
21p53 signaling pathway_Homo sapiens_hsa041151.35261152
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31785645
23Chemical carcinogenesis_Homo sapiens_hsa052041.29555872
24Steroid biosynthesis_Homo sapiens_hsa001001.29352639
25Axon guidance_Homo sapiens_hsa043601.28980021
26Pancreatic secretion_Homo sapiens_hsa049721.22407006
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21136767
28Renin secretion_Homo sapiens_hsa049241.20009407
29Tyrosine metabolism_Homo sapiens_hsa003501.16351299
30Tight junction_Homo sapiens_hsa045301.14922689
31Adherens junction_Homo sapiens_hsa045201.05591553
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00689993
33GnRH signaling pathway_Homo sapiens_hsa049120.98756404
34Nitrogen metabolism_Homo sapiens_hsa009100.95948255
35Long-term depression_Homo sapiens_hsa047300.91486420
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88112173
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85598951
38Bladder cancer_Homo sapiens_hsa052190.85536704
39ABC transporters_Homo sapiens_hsa020100.85494374
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.81837602
41Fat digestion and absorption_Homo sapiens_hsa049750.80923991
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79849686
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79383121
44Collecting duct acid secretion_Homo sapiens_hsa049660.76894407
45Basal cell carcinoma_Homo sapiens_hsa052170.76358118
46beta-Alanine metabolism_Homo sapiens_hsa004100.75563815
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74846046
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73379246
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73323811
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70809528
51Ras signaling pathway_Homo sapiens_hsa040140.69399208
52Platelet activation_Homo sapiens_hsa046110.69375438
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.68898713
54Gap junction_Homo sapiens_hsa045400.66019104
55Ovarian steroidogenesis_Homo sapiens_hsa049130.65161243
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.63406343
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61057077
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.59494880
59Pertussis_Homo sapiens_hsa051330.59039798
60Fatty acid biosynthesis_Homo sapiens_hsa000610.58202358
61ErbB signaling pathway_Homo sapiens_hsa040120.57839069
62Hippo signaling pathway_Homo sapiens_hsa043900.57681945
63Melanogenesis_Homo sapiens_hsa049160.57231899
64Proteoglycans in cancer_Homo sapiens_hsa052050.56920030
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53948022
66Hepatitis C_Homo sapiens_hsa051600.53577903
67MicroRNAs in cancer_Homo sapiens_hsa052060.53192957
68Folate biosynthesis_Homo sapiens_hsa007900.52804639
69Glutamatergic synapse_Homo sapiens_hsa047240.52578847
70Notch signaling pathway_Homo sapiens_hsa043300.50895788
71Gastric acid secretion_Homo sapiens_hsa049710.50884091
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49797408
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47001062
74MAPK signaling pathway_Homo sapiens_hsa040100.46733856
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46653186
76Mineral absorption_Homo sapiens_hsa049780.46632846
77Pancreatic cancer_Homo sapiens_hsa052120.46359869
78Calcium signaling pathway_Homo sapiens_hsa040200.46117186
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46096394
80Renin-angiotensin system_Homo sapiens_hsa046140.44987162
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44775140
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43972531
83Phototransduction_Homo sapiens_hsa047440.43212814
84Salivary secretion_Homo sapiens_hsa049700.43144771
85Thyroid cancer_Homo sapiens_hsa052160.42463331
86Glioma_Homo sapiens_hsa052140.42232020
87Vibrio cholerae infection_Homo sapiens_hsa051100.41287908
88Renal cell carcinoma_Homo sapiens_hsa052110.40954312
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.40622752
90Dorso-ventral axis formation_Homo sapiens_hsa043200.40451245
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40137948
92Oxytocin signaling pathway_Homo sapiens_hsa049210.40056435
93Pathways in cancer_Homo sapiens_hsa052000.38211730
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.37538110
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37148200
96Glycerolipid metabolism_Homo sapiens_hsa005610.36714434
97Tuberculosis_Homo sapiens_hsa051520.36462455
98Endocytosis_Homo sapiens_hsa041440.36444716
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34594141
100FoxO signaling pathway_Homo sapiens_hsa040680.34254696
101Glutathione metabolism_Homo sapiens_hsa004800.33812850
102Amoebiasis_Homo sapiens_hsa051460.33776389
103Protein digestion and absorption_Homo sapiens_hsa049740.33644873
104Circadian entrainment_Homo sapiens_hsa047130.33516122
105ECM-receptor interaction_Homo sapiens_hsa045120.33452699
106Hedgehog signaling pathway_Homo sapiens_hsa043400.33332962
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.31480278
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.31446407
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.30804807
110Toxoplasmosis_Homo sapiens_hsa051450.29777504
111AMPK signaling pathway_Homo sapiens_hsa041520.29305248
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28613814
113Salmonella infection_Homo sapiens_hsa051320.27596394
114Estrogen signaling pathway_Homo sapiens_hsa049150.27467868
115Wnt signaling pathway_Homo sapiens_hsa043100.26674223
116T cell receptor signaling pathway_Homo sapiens_hsa046600.26595557
117Inositol phosphate metabolism_Homo sapiens_hsa005620.25811426
118Legionellosis_Homo sapiens_hsa051340.25665817
119Long-term potentiation_Homo sapiens_hsa047200.24579073
120Rap1 signaling pathway_Homo sapiens_hsa040150.24453097
121TGF-beta signaling pathway_Homo sapiens_hsa043500.22551597
122Acute myeloid leukemia_Homo sapiens_hsa052210.20253892
123PPAR signaling pathway_Homo sapiens_hsa033200.18728884
124Choline metabolism in cancer_Homo sapiens_hsa052310.18637948
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18467895
126Taste transduction_Homo sapiens_hsa047420.18412102

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