KRT78

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.41811611
2peptide cross-linking (GO:0018149)8.61346842
3multicellular organismal water homeostasis (GO:0050891)8.35819979
4epidermal cell differentiation (GO:0009913)7.02230399
5water homeostasis (GO:0030104)6.96133562
6long-chain fatty acid biosynthetic process (GO:0042759)6.93119190
7hemidesmosome assembly (GO:0031581)6.77348445
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.65608786
9apical protein localization (GO:0045176)6.55394635
10sphingoid metabolic process (GO:0046519)6.37694347
11keratinocyte proliferation (GO:0043616)6.15543997
12sphingosine metabolic process (GO:0006670)6.00102852
13negative regulation of bone mineralization (GO:0030502)5.90139917
14glucosamine-containing compound catabolic process (GO:1901072)5.89845166
15negative regulation of interleukin-17 production (GO:0032700)5.70250390
16hair cell differentiation (GO:0035315)5.68589768
17interferon-gamma secretion (GO:0072643)5.64910824
18linoleic acid metabolic process (GO:0043651)5.54700505
19epidermis development (GO:0008544)5.46851542
20diol metabolic process (GO:0034311)5.31671145
21negative regulation of biomineral tissue development (GO:0070168)5.29445200
22regulation of ruffle assembly (GO:1900027)5.25730226
23molting cycle (GO:0042303)5.19923530
24hair cycle (GO:0042633)5.19923530
25negative regulation of homotypic cell-cell adhesion (GO:0034111)5.05656712
26intermediate filament organization (GO:0045109)4.76893239
27lipoxygenase pathway (GO:0019372)4.68129377
28localization within membrane (GO:0051668)4.64372883
29asymmetric protein localization (GO:0008105)4.63376958
30membrane raft organization (GO:0031579)4.54112489
31positive regulation of p38MAPK cascade (GO:1900745)4.50316903
32skin morphogenesis (GO:0043589)4.48021285
33regulation of chemokine secretion (GO:0090196)4.40358633
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.38509901
35positive regulation of interleukin-8 secretion (GO:2000484)4.29010180
36fatty acid elongation (GO:0030497)4.21819479
37regulation of phospholipase A2 activity (GO:0032429)4.19213105
38antimicrobial humoral response (GO:0019730)4.17898975
39regulation of cell proliferation involved in kidney development (GO:1901722)4.16357385
40positive regulation of endothelial cell differentiation (GO:0045603)4.14351567
41transepithelial transport (GO:0070633)4.12931334
42negative regulation of stress fiber assembly (GO:0051497)4.03286471
43phosphatidylinositol acyl-chain remodeling (GO:0036149)3.89211102
44regulation of hypersensitivity (GO:0002883)3.87402330
45prostanoid biosynthetic process (GO:0046457)3.86974829
46prostaglandin biosynthetic process (GO:0001516)3.86974829
47epithelium development (GO:0060429)3.81406001
48O-glycan processing (GO:0016266)3.81225144
49ectoderm development (GO:0007398)3.79795151
50defense response to fungus (GO:0050832)3.77722846
51primary alcohol catabolic process (GO:0034310)3.76354524
52epithelial cell differentiation (GO:0030855)3.71747397
53keratinocyte development (GO:0003334)3.67763333
54hair follicle morphogenesis (GO:0031069)3.61232264
55negative regulation of cytokine-mediated signaling pathway (GO:0001960)3.59426588
56cyclooxygenase pathway (GO:0019371)3.56747981
57regulation of cholesterol homeostasis (GO:2000188)3.56336766
58cardiolipin metabolic process (GO:0032048)3.56293041
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.52212490
60regulation of transforming growth factor beta1 production (GO:0032908)3.47901283
61negative regulation of cell-cell adhesion (GO:0022408)3.46140190
62superoxide anion generation (GO:0042554)3.44260765
63intestinal epithelial cell development (GO:0060576)3.43725188
64negative regulation of response to cytokine stimulus (GO:0060761)3.42916607
65regulation of platelet aggregation (GO:0090330)3.42653927
66regulation of p38MAPK cascade (GO:1900744)3.41886136
67regulation of interleukin-17 production (GO:0032660)3.37663279
68negative regulation of interleukin-2 production (GO:0032703)3.35021097
69cell wall macromolecule catabolic process (GO:0016998)3.34895560
70cell wall macromolecule metabolic process (GO:0044036)3.34895560
71positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.33063676
72phosphatidylserine acyl-chain remodeling (GO:0036150)3.27766009
73positive regulation of chemokine secretion (GO:0090197)3.25921313
74gap junction assembly (GO:0016264)3.24138292
75prostanoid metabolic process (GO:0006692)3.22815128
76prostaglandin metabolic process (GO:0006693)3.22815128
77regulation of natural killer cell differentiation (GO:0032823)3.22296997
78detection of bacterium (GO:0016045)3.21041037
79phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.16058251
80negative regulation of kidney development (GO:0090185)3.13050769
81positive regulation of vasodilation (GO:0045909)3.12674548
82regulation of protein polyubiquitination (GO:1902914)3.09569999
83ethanol metabolic process (GO:0006067)3.07817090
84regulation of mitochondrial depolarization (GO:0051900)3.07163787
85cellular response to interferon-alpha (GO:0035457)3.06800609
86chemical homeostasis within a tissue (GO:0048875)3.06069941
87negative regulation of T cell mediated immunity (GO:0002710)3.05096279
88regulation of interleukin-8 secretion (GO:2000482)3.04118062
89intermediate filament cytoskeleton organization (GO:0045104)3.04065657
90skin development (GO:0043588)3.03277407
91gland morphogenesis (GO:0022612)3.02423538
92negative regulation of interferon-gamma production (GO:0032689)3.02101541
93fatty-acyl-CoA metabolic process (GO:0035337)3.00103480
94phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.99929961
95regulation of keratinocyte differentiation (GO:0045616)2.99221562
96positive regulation of epidermis development (GO:0045684)2.99198311
97planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96954178
98positive regulation of glomerulus development (GO:0090193)2.96343057
99intermediate filament-based process (GO:0045103)2.95509565
100protein localization to endosome (GO:0036010)2.92820061
101establishment of planar polarity (GO:0001736)2.92464911
102establishment of tissue polarity (GO:0007164)2.92464911
103positive regulation of interleukin-4 production (GO:0032753)2.91044392
104amino sugar catabolic process (GO:0046348)2.86842638
105negative regulation of platelet activation (GO:0010544)2.86232185
106regulation of endothelial cell differentiation (GO:0045601)2.86013084
107positive regulation of chemokine biosynthetic process (GO:0045080)2.85630421
108unsaturated fatty acid biosynthetic process (GO:0006636)2.85109247
109negative regulation of axon extension involved in axon guidance (GO:0048843)2.84986700
110phosphatidylcholine acyl-chain remodeling (GO:0036151)2.84692242
111regulation of glomerular filtration (GO:0003093)2.84517243
112cardiac right ventricle morphogenesis (GO:0003215)2.84372647
113epithelial cell-cell adhesion (GO:0090136)2.84319063
114wound healing (GO:0042060)2.83693982
115negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81451879
116regulation of bile acid biosynthetic process (GO:0070857)2.81042412
117positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.80253234
118viral transcription (GO:0019083)2.79574365
119surfactant homeostasis (GO:0043129)2.79490761
120negative regulation of actin filament bundle assembly (GO:0032232)2.78492251
121negative regulation of cell fate specification (GO:0009996)2.77913305
122regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.72390964
123adhesion of symbiont to host cell (GO:0044650)2.72263149
124virion attachment to host cell (GO:0019062)2.72263149
125icosanoid secretion (GO:0032309)2.72262326
126arachidonic acid secretion (GO:0050482)2.72262326
127phosphatidylglycerol metabolic process (GO:0046471)2.72231108
128sphingolipid biosynthetic process (GO:0030148)2.71138491
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70231459
130eyelid development in camera-type eye (GO:0061029)2.70102357
131atrioventricular valve morphogenesis (GO:0003181)2.69704138
132detection of other organism (GO:0098543)2.69355664
133positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.68377998
134cellular response to calcium ion (GO:0071277)2.66343784
135positive regulation of monocyte chemotaxis (GO:0090026)2.65433561
136negative regulation of acute inflammatory response (GO:0002674)2.64630778
137positive regulation of epidermal cell differentiation (GO:0045606)2.63123875
138defense response to Gram-negative bacterium (GO:0050829)2.62419806
139hypotonic response (GO:0006971)2.60962477
140response to fungus (GO:0009620)2.53761345
141protein O-linked glycosylation (GO:0006493)2.53016935
142regulation of neuron projection regeneration (GO:0070570)2.52175836
143regulation of axon regeneration (GO:0048679)2.52175836
144regulation of integrin-mediated signaling pathway (GO:2001044)2.51557768
145sequestering of metal ion (GO:0051238)2.50875455
146early endosome to late endosome transport (GO:0045022)2.48508705
147regulation of natural killer cell activation (GO:0032814)2.44876886
148regulation of T cell migration (GO:2000404)2.42720447
149positive regulation of cellular amide metabolic process (GO:0034250)2.42118422
150ventricular cardiac muscle cell action potential (GO:0086005)2.32643055
151response to phenylpropanoid (GO:0080184)2.31722600
152negative regulation of cell-substrate adhesion (GO:0010812)2.30656757
153negative regulation of keratinocyte proliferation (GO:0010839)2.30469892
154endosome organization (GO:0007032)2.25916406
155keratinization (GO:0031424)16.3697619
156desmosome organization (GO:0002934)15.9837520
157establishment of skin barrier (GO:0061436)13.3690889
158regulation of water loss via skin (GO:0033561)12.2352775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.23099810
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.09426668
3ZNF263_19887448_ChIP-Seq_K562_Human2.71612081
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.66624889
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.59510266
6* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.41702476
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33984119
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.20213181
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.16980177
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10750453
11TP63_17297297_ChIP-ChIP_HaCaT_Human15.5306115
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93157387
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.85103106
14* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82255409
15* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82255409
16ERG_20517297_ChIP-Seq_VCAP_Human1.73074475
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70961520
18FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66515832
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62603123
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58481883
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.57494993
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48855253
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44804584
24SOX2_20726797_ChIP-Seq_SW620_Human1.44594116
25TP63_22573176_ChIP-Seq_HFKS_Human1.44062791
26TP63_23658742_ChIP-Seq_EP156T_Human1.39882254
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36701371
28GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.36310409
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.35216039
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32346830
31* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31052184
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26027872
33RACK7_27058665_Chip-Seq_MCF-7_Human1.23467889
34RXR_22108803_ChIP-Seq_LS180_Human1.23025842
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21023658
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20168340
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19739263
38GATA6_21074721_ChIP-Seq_CACO-2_Human1.18745814
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18591303
40GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.16996273
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16875990
42* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16457694
43CEBPB_22108803_ChIP-Seq_LS180_Human1.15246325
44KLF5_25053715_ChIP-Seq_YYC3_Human1.14118258
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.13503778
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13318342
47* CJUN_26792858_Chip-Seq_BT549_Human1.13301014
48CTCF_27219007_Chip-Seq_Bcells_Human1.09736607
49SMAD3_21741376_ChIP-Seq_HESCs_Human1.08004202
50MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.07507553
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07122196
52GATA1_22025678_ChIP-Seq_K562_Human1.06845331
53ATF3_27146783_Chip-Seq_COLON_Human1.02734788
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02428625
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02315752
56CTCF_20526341_ChIP-Seq_ESCs_Human1.02047120
57GATA4_25053715_ChIP-Seq_YYC3_Human1.01905401
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01709628
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.01666200
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01247974
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00398084
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00398084
63LXR_22292898_ChIP-Seq_THP-1_Human0.99674697
64TP53_20018659_ChIP-ChIP_R1E_Mouse0.99298126
65HTT_18923047_ChIP-ChIP_STHdh_Human0.97925682
66CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96972312
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96121441
68SA1_27219007_Chip-Seq_ERYTHROID_Human0.93981130
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93789290
70AHR_22903824_ChIP-Seq_MCF-7_Human0.93444822
71CLOCK_20551151_ChIP-Seq_293T_Human0.92779390
72FOXA1_25552417_ChIP-Seq_VCAP_Human0.92710868
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91605064
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.90860732
75GATA6_25053715_ChIP-Seq_YYC3_Human0.90345015
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89803238
77BCOR_27268052_Chip-Seq_Bcells_Human0.89544348
78AR_25329375_ChIP-Seq_VCAP_Human0.88767751
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88678856
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88548505
81SMC4_20622854_ChIP-Seq_HELA_Human0.87808624
82* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86963964
83SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86786840
84UBF1/2_26484160_Chip-Seq_HMECs_Human0.85838252
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.85106182
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84952566
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84920708
88NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84781332
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83731512
90BCAT_22108803_ChIP-Seq_LS180_Human0.83022162
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82685222
92ERG_21242973_ChIP-ChIP_JURKAT_Human0.82453760
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81710525
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80647768
95EP300_21415370_ChIP-Seq_HL-1_Mouse0.80427850
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80151045
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79801210
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79736302
99E2F1_20622854_ChIP-Seq_HELA_Human0.78962490
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78625574
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76665764
102FOXH1_21741376_ChIP-Seq_EPCs_Human0.76212448
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75968579
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75604902
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75204095
106* SA1_27219007_Chip-Seq_Bcells_Human0.72033873
107PPARA_22158963_ChIP-Seq_LIVER_Mouse0.72013951
108TP53_18474530_ChIP-ChIP_U2OS_Human0.71782239
109ELF5_23300383_ChIP-Seq_T47D_Human0.71520374
110P68_20966046_ChIP-Seq_HELA_Human0.71112081
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71103535
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70654492
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.70464093
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.70464093
115RBPJ_21746931_ChIP-Seq_IB4_Human0.70227120
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70063612
117KDM2B_26808549_Chip-Seq_K562_Human0.69862135
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68559594
119HNFA_21074721_ChIP-Seq_CACO-2_Human0.68444914
120AR_21572438_ChIP-Seq_LNCaP_Human0.68068865
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.66865345
122TCF4_22108803_ChIP-Seq_LS180_Human0.65492368
123VDR_22108803_ChIP-Seq_LS180_Human0.65243170
124EGR1_19032775_ChIP-ChIP_M12_Human0.65189113
125OCT1_27270436_Chip-Seq_PROSTATE_Human0.64448338
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.63344456
127* NANOG_20526341_ChIP-Seq_ESCs_Human0.62401403
128EZH2_27304074_Chip-Seq_ESCs_Mouse0.61892146
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.61583511
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60525829
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.59655959
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.59014833
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.58917339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.45498512
2MP0005275_abnormal_skin_tensile6.73046361
3MP0003941_abnormal_skin_development5.23885189
4MP0005501_abnormal_skin_physiology5.21086708
5MP0010234_abnormal_vibrissa_follicle4.83994624
6MP0004043_abnormal_pH_regulation3.87048027
7MP0002254_reproductive_system_inflammat3.75771392
8MP0001216_abnormal_epidermal_layer3.59604665
9MP0002060_abnormal_skin_morphology3.47652969
10MP0010771_integument_phenotype3.21294670
11MP0000566_synostosis3.19312241
12MP0000383_abnormal_hair_follicle3.18042058
13MP0003453_abnormal_keratinocyte_physiol2.96729620
14MP0004381_abnormal_hair_follicle2.87380216
15MP0010678_abnormal_skin_adnexa2.86677377
16MP0000467_abnormal_esophagus_morphology2.82371191
17MP0000579_abnormal_nail_morphology2.72144172
18MP0004947_skin_inflammation2.68526543
19MP0002098_abnormal_vibrissa_morphology2.60341729
20MP0000647_abnormal_sebaceous_gland2.49856740
21MP0004185_abnormal_adipocyte_glucose2.24639089
22MP0000377_abnormal_hair_follicle2.06489978
23MP0000762_abnormal_tongue_morphology2.04489644
24MP0003705_abnormal_hypodermis_morpholog1.99274234
25MP0005451_abnormal_body_composition1.91610143
26MP0003566_abnormal_cell_adhesion1.82976780
27MP0000427_abnormal_hair_cycle1.82784222
28MP0009931_abnormal_skin_appearance1.81512807
29MP0001191_abnormal_skin_condition1.74895312
30MP0002234_abnormal_pharynx_morphology1.70461934
31MP0001243_abnormal_dermal_layer1.66272330
32MP0004885_abnormal_endolymph1.64848245
33MP0002009_preneoplasia1.64175709
34MP0005409_darkened_coat_color1.49062150
35MP0001346_abnormal_lacrimal_gland1.48109295
36MP0000367_abnormal_coat/_hair1.38970350
37MP0008004_abnormal_stomach_pH1.36890848
38MP0009780_abnormal_chondrocyte_physiolo1.32272289
39MP0003878_abnormal_ear_physiology1.25622338
40MP0005377_hearing/vestibular/ear_phenot1.25622338
41MP0009379_abnormal_foot_pigmentation1.25525947
42MP0003191_abnormal_cellular_cholesterol1.07937920
43MP0004782_abnormal_surfactant_physiolog1.03672393
44MP0005503_abnormal_tendon_morphology1.01457562
45MP0002095_abnormal_skin_pigmentation0.91967027
46MP0001340_abnormal_eyelid_morphology0.91125810
47MP0010352_gastrointestinal_tract_polyps0.89908195
48MP0001851_eye_inflammation0.89612549
49MP0002006_tumorigenesis0.84861586
50MP0000465_gastrointestinal_hemorrhage0.84823013
51MP0003950_abnormal_plasma_membrane0.82500411
52MP0005666_abnormal_adipose_tissue0.82167978
53MP0003011_delayed_dark_adaptation0.80452704
54MP0009333_abnormal_splenocyte_physiolog0.79942159
55MP0005023_abnormal_wound_healing0.78637902
56MP0002177_abnormal_outer_ear0.77502080
57MP0002166_altered_tumor_susceptibility0.73847310
58MP0009053_abnormal_anal_canal0.73347769
59MP0000371_diluted_coat_color0.72460907
60MP0001188_hyperpigmentation0.70001046
61MP0000751_myopathy0.66992328
62MP0010368_abnormal_lymphatic_system0.65690733
63MP0000678_abnormal_parathyroid_gland0.64319291
64MP0000537_abnormal_urethra_morphology0.63561394
65MP0000627_abnormal_mammary_gland0.61750546
66MP0001784_abnormal_fluid_regulation0.61038245
67MP0000470_abnormal_stomach_morphology0.60887835
68MP0001765_abnormal_ion_homeostasis0.60418839
69MP0005076_abnormal_cell_differentiation0.57629825
70MP0005670_abnormal_white_adipose0.54612261
71MP0000003_abnormal_adipose_tissue0.51373267
72MP0000750_abnormal_muscle_regeneration0.51180705
73MP0002877_abnormal_melanocyte_morpholog0.49502287
74MP0001502_abnormal_circadian_rhythm0.49395721
75MP0003315_abnormal_perineum_morphology0.48814449
76MP0000749_muscle_degeneration0.48666398
77MP0005375_adipose_tissue_phenotype0.48347570
78MP0000747_muscle_weakness0.44975882
79MP0000538_abnormal_urinary_bladder0.44963406
80MP0003638_abnormal_response/metabolism_0.44947941
81MP0010030_abnormal_orbit_morphology0.44672973
82MP0002111_abnormal_tail_morphology0.44537369
83MP0003763_abnormal_thymus_physiology0.43234673
84MP0008961_abnormal_basal_metabolism0.42864177
85MP0002138_abnormal_hepatobiliary_system0.42033257
86MP0009115_abnormal_fat_cell0.40257282
87MP0006054_spinal_hemorrhage0.38975156
88MP0002108_abnormal_muscle_morphology0.38856566
89MP0005365_abnormal_bile_salt0.38215839
90MP0004130_abnormal_muscle_cell0.37308866
91MP0004019_abnormal_vitamin_homeostasis0.37179320
92MP0002277_abnormal_respiratory_mucosa0.36618116
93MP0003436_decreased_susceptibility_to0.36497104
94MP0002148_abnormal_hypersensitivity_rea0.35420913
95MP0000613_abnormal_salivary_gland0.35318978
96MP0003828_pulmonary_edema0.35009745
97MP0003755_abnormal_palate_morphology0.34936770
98MP0004264_abnormal_extraembryonic_tissu0.33987192
99MP0001299_abnormal_eye_distance/0.33514929
100MP0001984_abnormal_olfaction0.33475796
101MP0001177_atelectasis0.33266284
102MP0001756_abnormal_urination0.32278212
103MP0001849_ear_inflammation0.32146472
104MP0000759_abnormal_skeletal_muscle0.31855362
105MP0004145_abnormal_muscle_electrophysio0.31356531
106MP0004087_abnormal_muscle_fiber0.30728371
107MP0002075_abnormal_coat/hair_pigmentati0.29925969
108MP0001958_emphysema0.29421953
109MP0002106_abnormal_muscle_physiology0.28121237
110MP0001186_pigmentation_phenotype0.27528895
111MP0005193_abnormal_anterior_eye0.27228196
112MP0005166_decreased_susceptibility_to0.27196885
113MP0005636_abnormal_mineral_homeostasis0.26977199
114MP0004858_abnormal_nervous_system0.26178359
115MP0002332_abnormal_exercise_endurance0.25294346
116MP0004197_abnormal_fetal_growth/weight/0.25142548
117MP0002136_abnormal_kidney_physiology0.24793747
118MP0005508_abnormal_skeleton_morphology0.23370229
119MP0003937_abnormal_limbs/digits/tail_de0.22904348
120MP0000462_abnormal_digestive_system0.22534147
121MP0005620_abnormal_muscle_contractility0.21884868
122MP0006138_congestive_heart_failure0.20501630
123MP0008438_abnormal_cutaneous_collagen0.20328000
124MP0005369_muscle_phenotype0.20015286
125MP0003329_amyloid_beta_deposits0.19231135
126MP0000049_abnormal_middle_ear0.18917496
127MP0004036_abnormal_muscle_relaxation0.17900535
128MP0004272_abnormal_basement_membrane0.17515217
129MP0001879_abnormal_lymphatic_vessel0.17344775
130MP0009384_cardiac_valve_regurgitation0.17301558
131MP0000733_abnormal_muscle_development0.17194030
132MP0002971_abnormal_brown_adipose0.17045463
133MP0002249_abnormal_larynx_morphology0.16741935
134MP0005165_increased_susceptibility_to0.16411771
135MP0003045_fibrosis0.15836239
136MP0009643_abnormal_urine_homeostasis0.14902117
137MP0000681_abnormal_thyroid_gland0.13818464
138MP0004484_altered_response_of0.13408150

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.18328428
2Congenital ichthyosiform erythroderma (HP:0007431)7.16370415
3Hypotrichosis (HP:0001006)6.93609656
4Increased IgE level (HP:0003212)6.83825840
5Right ventricular cardiomyopathy (HP:0011663)6.47581244
6Conjunctival hamartoma (HP:0100780)6.30136388
7Plantar hyperkeratosis (HP:0007556)6.14397329
8Palmoplantar hyperkeratosis (HP:0000972)6.03656331
9Erythema (HP:0010783)5.99500331
10Erythroderma (HP:0001019)5.83213330
11Woolly hair (HP:0002224)5.73963769
12Lip pit (HP:0100267)5.70912424
13Palmar hyperkeratosis (HP:0010765)5.65515543
14Parakeratosis (HP:0001036)5.11024872
15Onycholysis (HP:0001806)4.80361048
16Abnormality of small intestinal villus morphology (HP:0011472)4.40310919
17Villous atrophy (HP:0011473)4.40310919
18Abnormality of nail color (HP:0100643)4.36707735
19Ectropion (HP:0000656)4.32514238
20Corneal erosion (HP:0200020)4.27185652
21Fragile nails (HP:0001808)4.26635431
22Hyporeflexia of lower limbs (HP:0002600)4.17276570
23Gangrene (HP:0100758)4.03877106
24Abnormal blistering of the skin (HP:0008066)4.03809052
25Oral leukoplakia (HP:0002745)3.88608758
26Hamartoma of the eye (HP:0010568)3.88605874
27Brittle hair (HP:0002299)3.86679222
28Milia (HP:0001056)3.81258174
29Hyperactive renin-angiotensin system (HP:0000841)3.70517308
30Thick nail (HP:0001805)3.69604982
31Palmoplantar keratoderma (HP:0000982)3.62538474
32Popliteal pterygium (HP:0009756)3.60796130
33Pili torti (HP:0003777)3.58037426
34Abnormality of secondary sexual hair (HP:0009888)3.50963542
35Abnormality of the axillary hair (HP:0100134)3.50963542
36Hypohidrosis (HP:0000966)3.50213131
37Distal lower limb muscle weakness (HP:0009053)3.37737249
38Pruritus (HP:0000989)3.33940713
39Ventricular tachycardia (HP:0004756)3.25294546
40Nail dystrophy (HP:0008404)3.21451077
41Abnormality of the salivary glands (HP:0010286)3.17599876
42Hyperkalemia (HP:0002153)3.15327438
43Distal arthrogryposis (HP:0005684)3.11863229
44Furrowed tongue (HP:0000221)3.08907348
45Eczematoid dermatitis (HP:0000976)3.04880503
46Absent eyelashes (HP:0000561)3.01191892
47Advanced eruption of teeth (HP:0006288)2.98716821
48Areflexia of lower limbs (HP:0002522)2.98126968
49Curly hair (HP:0002212)2.97177487
50Increased connective tissue (HP:0009025)2.96517497
51Nasal polyposis (HP:0100582)2.92870459
52Round ear (HP:0100830)2.92259969
53Myopathic facies (HP:0002058)2.87637757
54Hypoplastic labia majora (HP:0000059)2.83849044
55Exercise-induced myalgia (HP:0003738)2.81651974
56Muscle fiber inclusion bodies (HP:0100299)2.80930661
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.78846854
58Acanthosis nigricans (HP:0000956)2.73040328
59Natal tooth (HP:0000695)2.71813514
60Type 1 muscle fiber predominance (HP:0003803)2.65762459
61Sparse eyelashes (HP:0000653)2.63789347
62Nemaline bodies (HP:0003798)2.60490223
63Absent hair (HP:0002298)2.56034858
64Abnormality of the labia majora (HP:0012881)2.55045577
65Urticaria (HP:0001025)2.50529398
66Abnormality of the nasal mucosa (HP:0000433)2.47153664
67Lack of skin elasticity (HP:0100679)2.44965165
68Decreased circulating renin level (HP:0003351)2.44819801
69Chronic bronchitis (HP:0004469)2.38298787
70Autoamputation (HP:0001218)2.36410236
71Sparse scalp hair (HP:0002209)2.35077801
72Atrophic scars (HP:0001075)2.31525810
73Ulnar deviation of the wrist (HP:0003049)2.29426120
74Paralysis (HP:0003470)2.28908574
75Cystic hygroma (HP:0000476)2.25364360
76Muscle fiber splitting (HP:0003555)2.22317124
77Ventricular fibrillation (HP:0001663)2.21223377
78Pterygium (HP:0001059)2.19335002
79Abnormal hair laboratory examination (HP:0003328)2.18913478
80Calcaneovalgus deformity (HP:0001848)2.18891599
81Difficulty running (HP:0009046)2.16548076
82Blepharitis (HP:0000498)2.15789654
83Neonatal hypoglycemia (HP:0001998)2.11298235
84Hypergammaglobulinemia (HP:0010702)2.11030184
85Melanocytic nevus (HP:0000995)2.09959213
86Absent phalangeal crease (HP:0006109)2.09656206
87Alopecia of scalp (HP:0002293)2.09635843
88Papilloma (HP:0012740)2.06415099
89Verrucae (HP:0200043)2.06415099
90Hypokalemic alkalosis (HP:0001949)2.04890217
91Dry skin (HP:0000958)2.01141515
92Hypoparathyroidism (HP:0000829)1.99168137
93Fine hair (HP:0002213)1.99017554
94Abnormality of the neuromuscular junction (HP:0003398)1.96329744
95Fatigable weakness (HP:0003473)1.96329744
96Ridged nail (HP:0001807)1.95610854
97Calf muscle hypertrophy (HP:0008981)1.93137419
98Abnormality of placental membranes (HP:0011409)1.92075635
99Amniotic constriction ring (HP:0009775)1.92075635
100Abnormality of the gastric mucosa (HP:0004295)1.92036388
101Dehydration (HP:0001944)1.91121540
102Deformed tarsal bones (HP:0008119)1.90583796
103Septate vagina (HP:0001153)1.88341009
104Muscle hypertrophy of the lower extremities (HP:0008968)1.87096720
105Abnormality of chloride homeostasis (HP:0011422)1.84301422
106Malignant hyperthermia (HP:0002047)1.84199351
107Laryngomalacia (HP:0001601)1.83356001
108Skin pits (HP:0100276)1.83247492
109Oligodontia (HP:0000677)1.82819876
110Achilles tendon contracture (HP:0001771)1.76569759
111Hyperaldosteronism (HP:0000859)1.75748730
112Pustule (HP:0200039)1.74949729
113Severe Myopia (HP:0011003)1.73638494
114Increased variability in muscle fiber diameter (HP:0003557)1.72900128
115Sudden death (HP:0001699)1.72354521
116Labial hypoplasia (HP:0000066)1.72187222
117Abnormality of renin-angiotensin system (HP:0000847)1.71989475
118Renal salt wasting (HP:0000127)1.71142558
119Neck muscle weakness (HP:0000467)1.69782193
120Abnormality of skeletal muscle fiber size (HP:0012084)1.69441062
121Skin ulcer (HP:0200042)1.69157841
122Emphysema (HP:0002097)1.68878985
123Trismus (HP:0000211)1.68532803
124Follicular hyperkeratosis (HP:0007502)1.68261116
125Abnormal finger flexion creases (HP:0006143)1.67391525
126Hypoplasia of dental enamel (HP:0006297)1.64956419
127Aplasia involving bones of the extremities (HP:0009825)1.64652343
128Aplasia involving bones of the upper limbs (HP:0009823)1.64652343
129Aplasia of the phalanges of the hand (HP:0009802)1.64652343
130Hamartoma (HP:0010566)1.64237726
131Exercise-induced muscle cramps (HP:0003710)1.61956234
132Seborrheic dermatitis (HP:0001051)1.61760492
133Split foot (HP:0001839)1.61097761
134Hoarse voice (HP:0001609)1.59377657
135Hyperhidrosis (HP:0000975)1.57772449
136Malnutrition (HP:0004395)1.57049654
137Coarse hair (HP:0002208)1.55888262
138Neoplasm of the heart (HP:0100544)1.52152337
139Hypoplastic female external genitalia (HP:0012815)1.51582935
140Asthma (HP:0002099)1.44765370
141Anonychia (HP:0001798)1.39042646
142Slow-growing hair (HP:0002217)1.37347342
143Abnormality of hair growth rate (HP:0011363)1.37347342
144Corneal dystrophy (HP:0001131)1.36937436
145Recurrent corneal erosions (HP:0000495)1.35777508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.37368684
2MAPKAPK34.76325078
3MAP3K34.34398120
4TTN3.82109452
5FER3.61255385
6MST43.45319475
7MAP3K23.19225427
8PIK3CG2.92198246
9WNK12.71463890
10CAMK1D2.40140725
11RPS6KB22.34064544
12MET2.04323606
13SGK4942.03463833
14SGK2232.03463833
15FGFR21.98932507
16SGK21.93615715
17STK391.93224396
18SGK31.91780344
19PIM21.86428964
20CAMK1G1.84329035
21EPHA21.79596867
22WNK41.77040529
23OBSCN1.73834255
24MARK21.72495962
25NTRK21.66822483
26TRPM71.62937458
27LRRK21.58133472
28MAPKAPK51.56482660
29LATS11.48184171
30MAP2K61.45715589
31TGFBR11.42214636
32STK101.41876067
33FGFR41.41239340
34RIPK11.31622678
35TRIB31.31549380
36TGFBR21.31032616
37DYRK1B1.30698714
38TAOK11.29326965
39PTK61.28512025
40MAP2K31.26228730
41IRAK11.25579236
42ERN11.16161142
43PDK41.13550375
44PDK31.13550375
45EEF2K1.08739109
46PDGFRB1.07530933
47BLK1.05641812
48MAP3K111.05343241
49EPHA31.04389117
50MAP3K71.01770474
51ERBB30.98015401
52IRAK20.97473880
53FGFR30.97085347
54DMPK0.95797296
55STK30.93245176
56PDK20.91500675
57MAP3K120.90913931
58EPHB20.90587409
59FGFR10.90334444
60MAP3K60.89525594
61TESK10.85564508
62STK240.82223159
63AKT30.79486661
64MAPKAPK20.78373065
65BCR0.78223296
66RPS6KB10.77841915
67CSK0.77396945
68RIPK40.76758832
69IKBKE0.75862966
70IRAK40.75654250
71NME10.75498781
72TYRO30.74936413
73MAP3K10.72731169
74PHKG20.72412052
75PHKG10.72412052
76AKT20.70281569
77CDK120.68077068
78MAP3K140.67990321
79TNK20.66766281
80GRK70.64627449
81BRAF0.64362326
82EPHB10.64123050
83CDK60.64006049
84MTOR0.63989353
85MAPK70.63516164
86TYK20.62550220
87SGK10.61715665
88MAP2K40.61042552
89PRKD10.60895891
90RPS6KA40.60685840
91LATS20.60483991
92STK380.60368371
93PIK3CA0.59938477
94CHUK0.59119614
95GRK60.56435049
96PRKCI0.55824358
97ITK0.55613500
98ICK0.51233330
99PTK20.49281135
100ABL20.49121159
101STK38L0.48423223
102TTK0.47801438
103TIE10.46825469
104MAPK120.46568101
105HIPK20.46249050
106MAP2K10.42094149
107LIMK10.42061481
108RPS6KA20.41343656
109BMX0.41192002
110PAK30.36287658
111PRKD20.36113556
112KSR20.35787809
113JAK20.35539339
114ADRBK10.34868123
115PDGFRA0.33516419
116ERBB20.32270294
117NEK10.31973788
118MAP3K90.31787316
119DDR20.31410031
120CDK90.30659158
121ILK0.29154212
122TBK10.28661353
123RPS6KA10.28054186
124MAP3K50.27727021
125CSNK1D0.27163061
126NLK0.26287137
127CAMK40.25531150
128MAP2K20.25486809
129IKBKB0.25168132
130SRC0.24932905
131RET0.24835083
132GRK50.23926595
133PKN10.23364572
134STK110.22429276
135AURKB0.22000082
136PRKAA20.21940886
137GRK10.21222881
138PBK0.20461074
139FGR0.20221859
140SIK10.20093906
141ROCK10.19598235
142GSK3A0.19507941
143SIK30.19142665
144HCK0.19100051
145ROCK20.18948813
146DYRK30.18709548
147MAPK10.18397078
148AKT10.16774706
149MELK0.16740605
150PRKCE0.16278898
151CDK30.16244319
152MAPK30.15614478

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.57172700
2Sphingolipid metabolism_Homo sapiens_hsa006003.55441681
3Linoleic acid metabolism_Homo sapiens_hsa005913.37083809
4Arachidonic acid metabolism_Homo sapiens_hsa005903.32103721
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.30257312
6Phenylalanine metabolism_Homo sapiens_hsa003603.28808516
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.94907388
8Histidine metabolism_Homo sapiens_hsa003402.82618804
9Fatty acid elongation_Homo sapiens_hsa000622.29270912
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06094835
11Ether lipid metabolism_Homo sapiens_hsa005651.96928553
12VEGF signaling pathway_Homo sapiens_hsa043701.92745728
13Fat digestion and absorption_Homo sapiens_hsa049751.90956064
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90493516
15Ribosome_Homo sapiens_hsa030101.83782029
16Tyrosine metabolism_Homo sapiens_hsa003501.79366054
17Staphylococcus aureus infection_Homo sapiens_hsa051501.66767296
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66015514
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59580189
20Salivary secretion_Homo sapiens_hsa049701.58658663
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56904994
22Notch signaling pathway_Homo sapiens_hsa043301.55100271
23Tight junction_Homo sapiens_hsa045301.53314014
24Chemical carcinogenesis_Homo sapiens_hsa052041.43824520
25Adherens junction_Homo sapiens_hsa045201.35358780
26GnRH signaling pathway_Homo sapiens_hsa049121.32771640
27Sphingolipid signaling pathway_Homo sapiens_hsa040711.26130059
28Renin secretion_Homo sapiens_hsa049241.25052480
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18280972
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13801120
31Basal cell carcinoma_Homo sapiens_hsa052171.13285399
32beta-Alanine metabolism_Homo sapiens_hsa004101.12644701
33Axon guidance_Homo sapiens_hsa043601.09581758
34Collecting duct acid secretion_Homo sapiens_hsa049661.09141318
35Caffeine metabolism_Homo sapiens_hsa002321.09108386
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08495556
37Retinol metabolism_Homo sapiens_hsa008301.07188584
38Choline metabolism in cancer_Homo sapiens_hsa052311.04579992
39p53 signaling pathway_Homo sapiens_hsa041151.03801916
40Renal cell carcinoma_Homo sapiens_hsa052111.03132783
41ECM-receptor interaction_Homo sapiens_hsa045121.02551947
42Serotonergic synapse_Homo sapiens_hsa047261.01822703
43Proteoglycans in cancer_Homo sapiens_hsa052050.99757263
44Insulin signaling pathway_Homo sapiens_hsa049100.97893733
45Bladder cancer_Homo sapiens_hsa052190.96622979
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95269649
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.95078237
48Long-term depression_Homo sapiens_hsa047300.94246142
49Platelet activation_Homo sapiens_hsa046110.92131265
50Pancreatic secretion_Homo sapiens_hsa049720.91557251
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91122313
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.90165771
53ABC transporters_Homo sapiens_hsa020100.88122607
54Hippo signaling pathway_Homo sapiens_hsa043900.87358354
55Gastric acid secretion_Homo sapiens_hsa049710.83838716
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.81889431
57Melanogenesis_Homo sapiens_hsa049160.80637446
58Vibrio cholerae infection_Homo sapiens_hsa051100.79528647
59Fatty acid biosynthesis_Homo sapiens_hsa000610.79407649
60Sulfur metabolism_Homo sapiens_hsa009200.77193155
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76037983
62Pertussis_Homo sapiens_hsa051330.75308559
63Amoebiasis_Homo sapiens_hsa051460.71496346
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67961478
65Ras signaling pathway_Homo sapiens_hsa040140.66772938
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66665175
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65858654
68FoxO signaling pathway_Homo sapiens_hsa040680.65539061
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64976223
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.64972127
71Glycerolipid metabolism_Homo sapiens_hsa005610.64297578
72Oxytocin signaling pathway_Homo sapiens_hsa049210.63635987
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.63171079
74MAPK signaling pathway_Homo sapiens_hsa040100.62853518
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62419384
76Ovarian steroidogenesis_Homo sapiens_hsa049130.61721648
77Influenza A_Homo sapiens_hsa051640.60715387
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60699180
79MicroRNAs in cancer_Homo sapiens_hsa052060.60062547
80Hedgehog signaling pathway_Homo sapiens_hsa043400.59650197
81Hepatitis C_Homo sapiens_hsa051600.59390903
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59206616
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57348968
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.56767413
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56758108
86Calcium signaling pathway_Homo sapiens_hsa040200.56376511
87Toxoplasmosis_Homo sapiens_hsa051450.55270217
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55234347
89Shigellosis_Homo sapiens_hsa051310.54887860
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54596052
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.54385876
92Chronic myeloid leukemia_Homo sapiens_hsa052200.54250180
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53725331
94Endometrial cancer_Homo sapiens_hsa052130.53702495
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53654013
96Pancreatic cancer_Homo sapiens_hsa052120.53082809
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52721146
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52658285
99Phototransduction_Homo sapiens_hsa047440.52576929
100Fatty acid degradation_Homo sapiens_hsa000710.52089428
101Prostate cancer_Homo sapiens_hsa052150.51308510
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50502642
103Insulin resistance_Homo sapiens_hsa049310.49060887
104Wnt signaling pathway_Homo sapiens_hsa043100.48072723
105Inositol phosphate metabolism_Homo sapiens_hsa005620.47733671
106Rap1 signaling pathway_Homo sapiens_hsa040150.46659380
107TNF signaling pathway_Homo sapiens_hsa046680.45900654
108TGF-beta signaling pathway_Homo sapiens_hsa043500.44836833
109Prolactin signaling pathway_Homo sapiens_hsa049170.44544532
110Mineral absorption_Homo sapiens_hsa049780.44392115
111Salmonella infection_Homo sapiens_hsa051320.43498480
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.41262613
113Renin-angiotensin system_Homo sapiens_hsa046140.40973668
114PPAR signaling pathway_Homo sapiens_hsa033200.40222397
115Pathways in cancer_Homo sapiens_hsa052000.40019333
116Glutathione metabolism_Homo sapiens_hsa004800.39817262
117Estrogen signaling pathway_Homo sapiens_hsa049150.38971574
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37291708
119ErbB signaling pathway_Homo sapiens_hsa040120.36427689
120Dilated cardiomyopathy_Homo sapiens_hsa054140.36330831
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36002370
122Dorso-ventral axis formation_Homo sapiens_hsa043200.35082400
123Long-term potentiation_Homo sapiens_hsa047200.33932689
124Tuberculosis_Homo sapiens_hsa051520.33279344
125Focal adhesion_Homo sapiens_hsa045100.32865010
126Thyroid cancer_Homo sapiens_hsa052160.32608487
127Acute myeloid leukemia_Homo sapiens_hsa052210.31529418
128Endocytosis_Homo sapiens_hsa041440.30165996
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29834005
130Protein digestion and absorption_Homo sapiens_hsa049740.29825941
131Glioma_Homo sapiens_hsa052140.29632881
132Steroid biosynthesis_Homo sapiens_hsa001000.28887568
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27313384
134Vitamin digestion and absorption_Homo sapiens_hsa049770.27309342
135Glucagon signaling pathway_Homo sapiens_hsa049220.26777579

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