KRT79

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1linoleic acid metabolic process (GO:0043651)8.98413134
2establishment of skin barrier (GO:0061436)8.96953028
3regulation of water loss via skin (GO:0033561)8.26170123
4molting cycle (GO:0042303)8.24673067
5hair cycle (GO:0042633)8.24673067
6regulation of hair follicle development (GO:0051797)7.75137012
7peptide cross-linking (GO:0018149)6.84928965
8very long-chain fatty acid metabolic process (GO:0000038)6.80988343
9fatty-acyl-CoA biosynthetic process (GO:0046949)6.68436118
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.57331192
11keratinocyte differentiation (GO:0030216)6.53233830
12positive regulation of epidermis development (GO:0045684)5.85333026
13fatty-acyl-CoA metabolic process (GO:0035337)5.79238755
14regulation of hair cycle (GO:0042634)5.79038890
15epidermis development (GO:0008544)5.73592487
16retinol metabolic process (GO:0042572)5.66893603
17sphingoid metabolic process (GO:0046519)5.66263425
18intermediate filament cytoskeleton organization (GO:0045104)5.65440876
19multicellular organismal water homeostasis (GO:0050891)5.56894827
20thioester biosynthetic process (GO:0035384)5.52103907
21acyl-CoA biosynthetic process (GO:0071616)5.52103907
22long-chain fatty acid biosynthetic process (GO:0042759)5.51227363
23alpha-linolenic acid metabolic process (GO:0036109)5.48683837
24intermediate filament-based process (GO:0045103)5.45363601
25epidermal cell differentiation (GO:0009913)5.25742120
26hair cycle process (GO:0022405)5.23220995
27molting cycle process (GO:0022404)5.23220995
28phospholipid scrambling (GO:0017121)5.05867160
29diol metabolic process (GO:0034311)5.04819025
30positive regulation of keratinocyte differentiation (GO:0045618)5.00434795
31regulation of phospholipase A2 activity (GO:0032429)4.85611360
32keratinocyte proliferation (GO:0043616)4.84489157
33response to phenylpropanoid (GO:0080184)4.76961072
34lipoxygenase pathway (GO:0019372)4.75782900
35sphingosine metabolic process (GO:0006670)4.72541272
36skin morphogenesis (GO:0043589)4.69214407
37lymph vessel development (GO:0001945)4.68066296
38water homeostasis (GO:0030104)4.67856743
39detection of bacterium (GO:0016045)4.64238830
40negative regulation of cell fate specification (GO:0009996)4.58294216
41fatty acid elongation (GO:0030497)4.42862139
42negative regulation of keratinocyte proliferation (GO:0010839)4.38510519
43hemidesmosome assembly (GO:0031581)4.33623638
44keratinocyte development (GO:0003334)4.26650670
45primary alcohol metabolic process (GO:0034308)4.23479728
46triglyceride biosynthetic process (GO:0019432)4.22939660
47regulation of chemokine secretion (GO:0090196)4.18796360
48regulation of ruffle assembly (GO:1900027)4.01960464
49acylglycerol biosynthetic process (GO:0046463)3.98662708
50neutral lipid biosynthetic process (GO:0046460)3.98662708
51regulation of sequestering of triglyceride (GO:0010889)3.97541543
52negative regulation of cell fate commitment (GO:0010454)3.93855875
53detection of other organism (GO:0098543)3.93228369
54positive regulation of epidermal cell differentiation (GO:0045606)3.86653246
55G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.85777219
56regulation of epidermis development (GO:0045682)3.79042652
57regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.61332588
58epithelial cell differentiation involved in prostate gland development (GO:0060742)3.48469973
59regulation of glomerular filtration (GO:0003093)3.46975602
60thioester metabolic process (GO:0035383)3.40953588
61acyl-CoA metabolic process (GO:0006637)3.40953588
62G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.37023294
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34482322
64negative regulation of lipase activity (GO:0060192)3.33378939
65defense response to fungus (GO:0050832)3.30223590
66eyelid development in camera-type eye (GO:0061029)3.21660762
67primary alcohol catabolic process (GO:0034310)3.17345386
68ectoderm development (GO:0007398)3.17263347
69carnitine metabolic process (GO:0009437)3.15080118
70positive regulation of interleukin-8 secretion (GO:2000484)3.13767287
71negative regulation of stress fiber assembly (GO:0051497)3.09697081
72positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.08323130
73viral transcription (GO:0019083)3.07058728
74interferon-gamma secretion (GO:0072643)3.06609476
75regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06169648
76phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.03833154
77phosphatidylinositol acyl-chain remodeling (GO:0036149)3.02279270
78regulation of natural killer cell differentiation (GO:0032823)3.01203936
79adhesion of symbiont to host cell (GO:0044650)2.97990045
80virion attachment to host cell (GO:0019062)2.97990045
81fibrinolysis (GO:0042730)2.95563389
82regulation of cardioblast differentiation (GO:0051890)2.93310094
83non-canonical Wnt signaling pathway (GO:0035567)2.92068222
84ephrin receptor signaling pathway (GO:0048013)2.88012229
85phosphatidylserine acyl-chain remodeling (GO:0036150)2.85756625
86regulation of hypersensitivity (GO:0002883)2.85533522
87unsaturated fatty acid biosynthetic process (GO:0006636)2.85260837
88epithelium development (GO:0060429)2.84916408
89phosphatidylcholine acyl-chain remodeling (GO:0036151)2.82705905
90phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.82073366
91regulation of heterotypic cell-cell adhesion (GO:0034114)2.81465477
92renal system process involved in regulation of blood volume (GO:0001977)2.81304872
93translational termination (GO:0006415)2.78859702
94regulation of somitogenesis (GO:0014807)2.76067364
95regulation of transforming growth factor beta1 production (GO:0032908)2.73494274
96low-density lipoprotein particle clearance (GO:0034383)2.73365272
97long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72936595
98positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.72907953
99regulation of interleukin-8 secretion (GO:2000482)2.72306971
100negative regulation of interferon-gamma production (GO:0032689)2.72273711
101regulation of defense response to virus by host (GO:0050691)2.71230389
102glucosamine-containing compound catabolic process (GO:1901072)2.71046444
103regulation of transforming growth factor beta2 production (GO:0032909)2.70267743
104killing of cells of other organism (GO:0031640)2.69792883
105disruption of cells of other organism (GO:0044364)2.69792883
106lipid storage (GO:0019915)2.69343990
107positive regulation of Rho protein signal transduction (GO:0035025)2.69197545
108one-carbon compound transport (GO:0019755)2.65286995
109hair follicle development (GO:0001942)2.65265777
110fatty acid biosynthetic process (GO:0006633)2.64710139
111planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63267953
112adhesion of symbiont to host (GO:0044406)2.61908916
113phosphatidylserine metabolic process (GO:0006658)2.58679787
114positive regulation of chemokine secretion (GO:0090197)2.56757455
115chemosensory behavior (GO:0007635)2.55304811
116negative regulation of acute inflammatory response (GO:0002674)2.55071803
117positive regulation of cholesterol efflux (GO:0010875)2.54328536
118negative regulation of kidney development (GO:0090185)2.53750534
119regulation of epidermal cell differentiation (GO:0045604)2.53412118
120ribosomal small subunit biogenesis (GO:0042274)2.53079316
121mesenchymal to epithelial transition (GO:0060231)2.51794040
122regulation of keratinocyte differentiation (GO:0045616)2.50540173
123ventricular cardiac muscle cell action potential (GO:0086005)2.50316771
124response to UV-B (GO:0010224)2.47051001
125regulation of cell fate specification (GO:0042659)2.47046816
126negative regulation of T cell mediated immunity (GO:0002710)2.45373099
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44907918
128phospholipid efflux (GO:0033700)2.44624928
129long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.43455656
130chemical homeostasis within a tissue (GO:0048875)2.43270769
131lateral sprouting from an epithelium (GO:0060601)2.42421853
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.41730878
133ethanol metabolic process (GO:0006067)2.40981320
134cardiac right ventricle morphogenesis (GO:0003215)2.40683086
135neural crest cell development (GO:0014032)2.40235062
136cytoskeletal anchoring at plasma membrane (GO:0007016)2.40135164
137hair follicle morphogenesis (GO:0031069)2.39690372
138atrioventricular valve morphogenesis (GO:0003181)2.36958774
139polyol transport (GO:0015791)2.35964443
140cell communication involved in cardiac conduction (GO:0086065)2.34617150
141regulation of neuron projection regeneration (GO:0070570)2.33783879
142regulation of axon regeneration (GO:0048679)2.33783879
143positive regulation of cholesterol transport (GO:0032376)2.32423137
144phosphatidic acid biosynthetic process (GO:0006654)2.32276476
145phosphatidic acid metabolic process (GO:0046473)2.32276476
146triglyceride metabolic process (GO:0006641)2.27241170
147alditol phosphate metabolic process (GO:0052646)2.25764486
148negative regulation of execution phase of apoptosis (GO:1900118)2.22910042
149polarized epithelial cell differentiation (GO:0030859)2.18663193
150positive regulation of lipid storage (GO:0010884)2.14820681
151response to fungus (GO:0009620)2.11646365
152establishment of planar polarity (GO:0001736)2.07131038
153establishment of tissue polarity (GO:0007164)2.07131038
154acylglycerol metabolic process (GO:0006639)2.05514529
155long-chain fatty acid metabolic process (GO:0001676)2.04213490
156neutral lipid metabolic process (GO:0006638)2.02275679
157amino-acid betaine metabolic process (GO:0006577)2.00719477
158desmosome organization (GO:0002934)14.3335970
159keratinization (GO:0031424)12.0085045
160positive regulation of hair cycle (GO:0042635)11.0175632
161positive regulation of hair follicle development (GO:0051798)11.0175632
162intermediate filament organization (GO:0045109)10.1262229
163skin development (GO:0043588)1.98844075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.66168729
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.16273335
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.00114909
4P63_26484246_Chip-Seq_KERATINOCYTES_Human2.53244352
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.51938498
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.27359293
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.27134217
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.11469832
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.04273331
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.01878264
11TP63_17297297_ChIP-ChIP_HaCaT_Human12.6933510
12* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68873992
13* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68873992
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65628486
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.59676576
16TP53_18474530_ChIP-ChIP_U2OS_Human1.57632531
17ERG_20517297_ChIP-Seq_VCAP_Human1.57498361
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.54938617
19CTCF_20526341_ChIP-Seq_ESCs_Human1.53624395
20SOX2_20726797_ChIP-Seq_SW620_Human1.51768269
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44452884
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35535658
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.34947115
24TP63_23658742_ChIP-Seq_EP156T_Human1.33274305
25BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.33104498
26CLOCK_20551151_ChIP-Seq_293T_Human1.31030870
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30645893
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29639855
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28832777
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28758682
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.28742125
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27612213
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27447442
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27447442
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.26650608
36E2F1_20622854_ChIP-Seq_HELA_Human1.25287797
37CJUN_26792858_Chip-Seq_BT549_Human1.24593379
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23640863
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.23508190
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.23471119
41* BCL6_27268052_Chip-Seq_Bcells_Human1.19398579
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.19258752
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.18739739
44AHR_22903824_ChIP-Seq_MCF-7_Human1.18476415
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.18292695
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17395861
47RACK7_27058665_Chip-Seq_MCF-7_Human1.16268785
48KLF5_25053715_ChIP-Seq_YYC3_Human1.15703769
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14986840
50P68_20966046_ChIP-Seq_HELA_Human1.13456549
51AR_21572438_ChIP-Seq_LNCaP_Human1.11609237
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09648205
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08732295
54* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08317663
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06277060
56TP63_22573176_ChIP-Seq_HFKS_Human1.06102958
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05054342
58* LXR_22292898_ChIP-Seq_THP-1_Human1.03879000
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03691585
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03609457
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03578960
62TAF2_19829295_ChIP-Seq_ESCs_Human1.03192965
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.02737043
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.02737043
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00833334
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00195252
67GATA3_24758297_ChIP-Seq_MCF-7_Human0.99908039
68MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99789808
69TP53_16413492_ChIP-PET_HCT116_Human0.99377340
70ARNT_22903824_ChIP-Seq_MCF-7_Human0.98663407
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98535409
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98478023
73CDX2_20551321_ChIP-Seq_CACO-2_Human0.98387750
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97123287
75ATF3_27146783_Chip-Seq_COLON_Human0.96100879
76RXR_22158963_ChIP-Seq_LIVER_Mouse0.94956435
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94704264
78RXR_22108803_ChIP-Seq_LS180_Human0.94288031
79GATA4_25053715_ChIP-Seq_YYC3_Human0.94239614
80CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93589881
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93404211
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93023068
83HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92043768
84* FOXH1_21741376_ChIP-Seq_ESCs_Human0.91904496
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91208128
86BCAT_22108803_ChIP-Seq_LS180_Human0.90264415
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89908499
88TCF4_18268006_ChIP-ChIP_LS174T_Human0.89512293
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89034119
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.88546723
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88163657
92VDR_22108803_ChIP-Seq_LS180_Human0.87772105
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86770285
94CTCF_27219007_Chip-Seq_Bcells_Human0.84932439
95* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84909822
96EGR1_19032775_ChIP-ChIP_M12_Human0.84682707
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84343488
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84266904
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81482769
100* SMC4_20622854_ChIP-Seq_HELA_Human0.81067135
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81016631
102* ELK3_25401928_ChIP-Seq_HUVEC_Human0.80205774
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80065220
104ZNF263_19887448_ChIP-Seq_K562_Human0.79147504
105RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78768985
106SMAD4_21741376_ChIP-Seq_ESCs_Human0.78624947
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77396134
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76185643
109HTT_18923047_ChIP-ChIP_STHdh_Human0.74483688
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74116543
111RING1B_27294783_Chip-Seq_NPCs_Mouse0.74090576
112HNFA_21074721_ChIP-Seq_CACO-2_Human0.74031302
113TCF4_22108803_ChIP-Seq_LS180_Human0.73525454
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73117277
115GATA6_25053715_ChIP-Seq_YYC3_Human0.71650014
116KAP1_27257070_Chip-Seq_ESCs_Mouse0.71249086
117LXR_22158963_ChIP-Seq_LIVER_Mouse0.70983562
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.70525199
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69788683
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69772344
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.69513233
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69098248
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68351536
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.68219884
125KDM2B_26808549_Chip-Seq_K562_Human0.67914654
126P53_21459846_ChIP-Seq_SAOS-2_Human0.67798514
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66812815
128GATA6_21074721_ChIP-Seq_CACO-2_Human0.66584156
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.66509271
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.66139099
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65806893
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.65510310
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.65308170
134P300_27268052_Chip-Seq_Bcells_Human0.64810088
135SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64788508
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.64054836
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63316925
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63033535
139JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.62674884
140PPARA_22158963_ChIP-Seq_LIVER_Mouse0.62370337
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62111072
142* BCOR_27268052_Chip-Seq_Bcells_Human0.61605790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle7.10700036
2MP0000579_abnormal_nail_morphology6.98039616
3MP0002796_impaired_skin_barrier6.46319820
4MP0005501_abnormal_skin_physiology4.04490666
5MP0002098_abnormal_vibrissa_morphology4.00129548
6MP0005275_abnormal_skin_tensile3.81493072
7MP0003941_abnormal_skin_development3.81476366
8MP0010234_abnormal_vibrissa_follicle3.77622553
9MP0000427_abnormal_hair_cycle3.61649640
10MP0003705_abnormal_hypodermis_morpholog3.54914946
11MP0005075_abnormal_melanosome_morpholog3.26837471
12MP0000377_abnormal_hair_follicle3.13370722
13MP0002060_abnormal_skin_morphology3.10003689
14MP0000647_abnormal_sebaceous_gland3.09646202
15MP0001216_abnormal_epidermal_layer3.07693975
16MP0003453_abnormal_keratinocyte_physiol2.72445884
17MP0010771_integument_phenotype2.54652316
18MP0000762_abnormal_tongue_morphology2.54585204
19MP0000383_abnormal_hair_follicle2.20571538
20MP0002009_preneoplasia2.20321928
21MP0002254_reproductive_system_inflammat2.10518701
22MP0010678_abnormal_skin_adnexa2.05695058
23MP0001243_abnormal_dermal_layer2.00656389
24MP0004947_skin_inflammation1.97679462
25MP0000467_abnormal_esophagus_morphology1.81167126
26MP0005451_abnormal_body_composition1.74746507
27MP0003566_abnormal_cell_adhesion1.72515068
28MP0000367_abnormal_coat/_hair1.64138471
29MP0000015_abnormal_ear_pigmentation1.63798459
30MP0000537_abnormal_urethra_morphology1.53125610
31MP0005174_abnormal_tail_pigmentation1.49942748
32MP0003878_abnormal_ear_physiology1.46871345
33MP0005377_hearing/vestibular/ear_phenot1.46871345
34MP0001191_abnormal_skin_condition1.41734095
35MP0009931_abnormal_skin_appearance1.40489359
36MP0003011_delayed_dark_adaptation1.37969521
37MP0001851_eye_inflammation1.36200397
38MP0000516_abnormal_urinary_system1.32430284
39MP0005367_renal/urinary_system_phenotyp1.32430284
40MP0001346_abnormal_lacrimal_gland1.30797942
41MP0000465_gastrointestinal_hemorrhage1.26358911
42MP0003315_abnormal_perineum_morphology1.26331420
43MP0009053_abnormal_anal_canal1.25273748
44MP0002249_abnormal_larynx_morphology1.19939482
45MP0002234_abnormal_pharynx_morphology1.11256587
46MP0000566_synostosis1.07842579
47MP0001340_abnormal_eyelid_morphology0.93924199
48MP0004019_abnormal_vitamin_homeostasis0.91055335
49MP0002006_tumorigenesis0.82078436
50MP0003191_abnormal_cellular_cholesterol0.80881350
51MP0002166_altered_tumor_susceptibility0.74911433
52MP0004185_abnormal_adipocyte_glucose0.74427431
53MP0002282_abnormal_trachea_morphology0.74275531
54MP0003755_abnormal_palate_morphology0.71548445
55MP0001661_extended_life_span0.70468629
56MP0010352_gastrointestinal_tract_polyps0.68541865
57MP0009384_cardiac_valve_regurgitation0.67791428
58MP0004264_abnormal_extraembryonic_tissu0.66616647
59MP0000627_abnormal_mammary_gland0.66196226
60MP0003724_increased_susceptibility_to0.65623957
61MP0004272_abnormal_basement_membrane0.62367738
62MP0003828_pulmonary_edema0.60753954
63MP0009379_abnormal_foot_pigmentation0.56130787
64MP0010368_abnormal_lymphatic_system0.55984257
65MP0005076_abnormal_cell_differentiation0.54036505
66MP0010030_abnormal_orbit_morphology0.53727109
67MP0004885_abnormal_endolymph0.53670091
68MP0005187_abnormal_penis_morphology0.51867315
69MP0006035_abnormal_mitochondrial_morpho0.51572033
70MP0002970_abnormal_white_adipose0.51509007
71MP0005085_abnormal_gallbladder_physiolo0.50060618
72MP0005409_darkened_coat_color0.48188633
73MP0005023_abnormal_wound_healing0.47988905
74MP0002090_abnormal_vision0.44678023
75MP0002877_abnormal_melanocyte_morpholog0.43878620
76MP0005666_abnormal_adipose_tissue0.41961473
77MP0003950_abnormal_plasma_membrane0.41800647
78MP0005535_abnormal_body_temperature0.41285945
79MP0005623_abnormal_meninges_morphology0.40911484
80MP0002971_abnormal_brown_adipose0.40861511
81MP0005508_abnormal_skeleton_morphology0.40749068
82MP0006054_spinal_hemorrhage0.40686465
83MP0003763_abnormal_thymus_physiology0.39534511
84MP0009780_abnormal_chondrocyte_physiolo0.39254382
85MP0001188_hyperpigmentation0.37665474
86MP0001853_heart_inflammation0.36879812
87MP0003638_abnormal_response/metabolism_0.36648877
88MP0001879_abnormal_lymphatic_vessel0.36196155
89MP0001784_abnormal_fluid_regulation0.34703672
90MP0003300_gastrointestinal_ulcer0.34174204
91MP0001186_pigmentation_phenotype0.33823385
92MP0000678_abnormal_parathyroid_gland0.32168163
93MP0004782_abnormal_surfactant_physiolog0.32151034
94MP0008438_abnormal_cutaneous_collagen0.31520955
95MP0003436_decreased_susceptibility_to0.31271187
96MP0002095_abnormal_skin_pigmentation0.30998226
97MP0003195_calcinosis0.29649678
98MP0002233_abnormal_nose_morphology0.28753945
99MP0009250_abnormal_appendicular_skeleto0.28527550
100MP0003936_abnormal_reproductive_system0.28518539
101MP0002177_abnormal_outer_ear0.28060631
102MP0002697_abnormal_eye_size0.27084157
103MP0002148_abnormal_hypersensitivity_rea0.26865269
104MP0000470_abnormal_stomach_morphology0.26849957
105MP0003329_amyloid_beta_deposits0.26752414
106MP0003385_abnormal_body_wall0.26562688
107MP0010386_abnormal_urinary_bladder0.25751670
108MP0000685_abnormal_immune_system0.25654580
109MP0001984_abnormal_olfaction0.25447227
110MP0001542_abnormal_bone_strength0.24943295
111MP0005248_abnormal_Harderian_gland0.24815957
112MP0005647_abnormal_sex_gland0.24507719
113MP0004858_abnormal_nervous_system0.23721073
114MP0001958_emphysema0.23611547
115MP0005503_abnormal_tendon_morphology0.23130895
116MP0001849_ear_inflammation0.20651525
117MP0000462_abnormal_digestive_system0.19460454
118MP0009333_abnormal_splenocyte_physiolog0.16303330
119MP0002111_abnormal_tail_morphology0.16239283
120MP0002118_abnormal_lipid_homeostasis0.15784263
121MP0003448_altered_tumor_morphology0.15403456
122MP0000372_irregular_coat_pigmentation0.14097708
123MP0005375_adipose_tissue_phenotype0.13871149
124MP0001919_abnormal_reproductive_system0.13282936
125MP0001881_abnormal_mammary_gland0.09546142
126MP0004742_abnormal_vestibular_system0.09190144
127MP0002133_abnormal_respiratory_system0.08158349
128MP0005388_respiratory_system_phenotype0.08158349
129MP0009115_abnormal_fat_cell0.07242349
130MP0006138_congestive_heart_failure0.06699108
131MP0005671_abnormal_response_to0.06492798
132MP0000858_altered_metastatic_potential0.05945476
133MP0001533_abnormal_skeleton_physiology0.05789697

Predicted human phenotypes

RankGene SetZ-score
1Natal tooth (HP:0000695)9.38463019
2Dry hair (HP:0011359)7.91169923
3Epidermoid cyst (HP:0200040)7.80717153
4Palmoplantar hyperkeratosis (HP:0000972)7.72257993
5Palmar hyperkeratosis (HP:0010765)7.25003712
6Abnormality of hair growth rate (HP:0011363)6.96440112
7Slow-growing hair (HP:0002217)6.96440112
8Plantar hyperkeratosis (HP:0007556)6.76791688
9Hypotrichosis (HP:0001006)6.54576287
10Advanced eruption of teeth (HP:0006288)6.26681009
11Parakeratosis (HP:0001036)6.17747289
12Woolly hair (HP:0002224)6.05320804
13Right ventricular cardiomyopathy (HP:0011663)5.63514690
14Sparse scalp hair (HP:0002209)5.18990227
15Absent eyelashes (HP:0000561)5.06316001
16Angiofibromas (HP:0010615)4.81731926
17Adenoma sebaceum (HP:0009720)4.81731926
18Increased IgE level (HP:0003212)4.57667727
19Lip pit (HP:0100267)4.51680000
20Nail dystrophy (HP:0008404)4.46443168
21Erythema (HP:0010783)4.00672291
22Abnormal blistering of the skin (HP:0008066)3.92833577
23Absent hair (HP:0002298)3.85061179
24Fragile nails (HP:0001808)3.64548052
25Laryngomalacia (HP:0001601)3.57141110
26Sparse eyelashes (HP:0000653)3.53602910
27Absent eyebrow (HP:0002223)3.46721312
28Pili torti (HP:0003777)3.45940994
29Onycholysis (HP:0001806)3.44860098
30Fine hair (HP:0002213)3.41713808
31Ventricular tachycardia (HP:0004756)3.33693455
32Congenital ichthyosiform erythroderma (HP:0007431)3.30100915
33Corneal dystrophy (HP:0001131)3.18507795
34Hoarse voice (HP:0001609)3.15124447
35Milia (HP:0001056)3.09391209
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95002314
37Thick nail (HP:0001805)2.94482003
38Erythroderma (HP:0001019)2.85525931
39Conjunctival hamartoma (HP:0100780)2.74158729
40Palmoplantar keratoderma (HP:0000982)2.72094350
41Abnormality of the axillary hair (HP:0100134)2.66795423
42Abnormality of secondary sexual hair (HP:0009888)2.66795423
43Acanthosis nigricans (HP:0000956)2.59915063
44Fibroma (HP:0010614)2.58116687
45Alopecia of scalp (HP:0002293)2.54728554
46Ventricular fibrillation (HP:0001663)2.52366663
47Fibrous tissue neoplasm (HP:0012316)2.50336272
48Abnormal hair laboratory examination (HP:0003328)2.48665433
49Oligodontia (HP:0000677)2.34572588
50Anonychia (HP:0001798)2.33917702
51Hamartoma (HP:0010566)2.31304942
52Abnormality of the pupil (HP:0000615)2.25035039
53Corneal erosion (HP:0200020)2.18677596
54Melanocytic nevus (HP:0000995)2.17615594
55Popliteal pterygium (HP:0009756)2.17348309
56Hypohidrosis (HP:0000966)2.14110977
57Abnormality of the gastric mucosa (HP:0004295)2.11314977
58Abnormal hemoglobin (HP:0011902)2.08066781
59Skin pits (HP:0100276)2.06452547
60Double outlet right ventricle (HP:0001719)2.06140854
61Congenital malformation of the right heart (HP:0011723)2.06140854
62Distal lower limb muscle weakness (HP:0009053)2.05434354
63Atrophic scars (HP:0001075)2.03882713
64Pruritus (HP:0000989)2.02280678
65Follicular hyperkeratosis (HP:0007502)2.00522077
66Coarse hair (HP:0002208)2.00012102
67Abnormality of nail color (HP:0100643)11.0380375
68Oral leukoplakia (HP:0002745)1.96981015
69Hypoplasia of the iris (HP:0007676)1.95753220
70Aplasia cutis congenita (HP:0001057)1.95529133
71Hyporeflexia of lower limbs (HP:0002600)1.93854884
72Gangrene (HP:0100758)1.91185492
73Neonatal death (HP:0003811)1.90805045
74Concave nail (HP:0001598)1.90042156
75Curly hair (HP:0002212)1.88938144
76Abnormal sex determination (HP:0012244)1.87058572
77Sex reversal (HP:0012245)1.87058572
78Down-sloping shoulders (HP:0200021)1.85718465
79Brittle hair (HP:0002299)1.85580063
80Eczematoid dermatitis (HP:0000976)1.82679562
81Congenital, generalized hypertrichosis (HP:0004540)1.81170246
82Hyperhidrosis (HP:0000975)1.77195571
83Upper limb muscle weakness (HP:0003484)1.75789324
84Urticaria (HP:0001025)1.74969918
85Hypoplasia of dental enamel (HP:0006297)1.74789400
86Ridged nail (HP:0001807)1.69979051
87Premature rupture of membranes (HP:0001788)1.68191246
88Severe Myopia (HP:0011003)1.66775069
89Fatigable weakness (HP:0003473)1.63638494
90Abnormality of the neuromuscular junction (HP:0003398)1.63638494
91Skin ulcer (HP:0200042)1.63027800
92Abnormality of the dental root (HP:0006486)1.62423324
93Taurodontia (HP:0000679)1.62423324
94Abnormality of permanent molar morphology (HP:0011071)1.62423324
95Hamartoma of the eye (HP:0010568)1.60456489
96Achilles tendon contracture (HP:0001771)1.59539315
97Abnormality of molar morphology (HP:0011070)1.53160302
98Abnormality of molar (HP:0011077)1.53160302
99Abnormality of the Achilles tendon (HP:0005109)1.50485666
100Fragile skin (HP:0001030)1.49300190
101Carious teeth (HP:0000670)1.48978974
102Ectropion (HP:0000656)1.47926759
103Hypergammaglobulinemia (HP:0010702)1.47674874
104Septate vagina (HP:0001153)1.47193666
105Aplasia involving bones of the upper limbs (HP:0009823)1.47040743
106Aplasia of the phalanges of the hand (HP:0009802)1.47040743
107Aplasia involving bones of the extremities (HP:0009825)1.47040743
108Conical tooth (HP:0000698)1.46995977
109Abnormality of oral frenula (HP:0000190)1.46446594
110Verrucae (HP:0200043)1.45633697
111Papilloma (HP:0012740)1.45633697
112Abnormality of the aortic arch (HP:0012303)1.45374538
113Increased connective tissue (HP:0009025)1.45217124
114Bifid scrotum (HP:0000048)1.43634626
115Nasolacrimal duct obstruction (HP:0000579)1.43351710
116Abnormality of the parietal bone (HP:0002696)1.42381876
117Abnormality of the dental pulp (HP:0006479)1.42264846
118Abnormality of the salivary glands (HP:0010286)1.41743472
119Blepharitis (HP:0000498)1.41085632
120Pterygium (HP:0001059)1.40192461
121Furrowed tongue (HP:0000221)1.39784508
122Supernumerary ribs (HP:0005815)1.39698048
123Split foot (HP:0001839)1.38127238
124Abnormality of the fingernails (HP:0001231)1.37049566
125Obstructive sleep apnea (HP:0002870)1.34395200
126Testicular atrophy (HP:0000029)1.34387118
127Dry skin (HP:0000958)1.33724083
128Hypoplastic labia majora (HP:0000059)1.33643028
129Peritonitis (HP:0002586)1.33507089
130Ulnar claw (HP:0001178)1.32964538
131Xerostomia (HP:0000217)1.32732949
132Type 1 muscle fiber predominance (HP:0003803)1.32229408
133Distal lower limb amyotrophy (HP:0008944)1.30335618
134Multifactorial inheritance (HP:0001426)1.26518533
135Selective tooth agenesis (HP:0001592)1.20575676
136Neonatal short-limb short stature (HP:0008921)1.20244985
137Craniofacial hyperostosis (HP:0004493)1.18781692
138Seborrheic dermatitis (HP:0001051)1.07598033
139Abnormality of the labia majora (HP:0012881)1.06572331
140Osteolytic defects of the hand bones (HP:0009699)1.05930761
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.05930761
142Neonatal onset (HP:0003623)1.05900799
143Coronal craniosynostosis (HP:0004440)1.03175495
144Abnormality of the lacrimal duct (HP:0011481)1.00845376
145Abnormality of the costochondral junction (HP:0000919)0.99291543
146Recurrent corneal erosions (HP:0000495)0.99195875
147Duplicated collecting system (HP:0000081)0.98312506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.78674327
2MST45.28678088
3MAP3K64.62309933
4TGFBR14.08485860
5FER3.47837702
6MAPKAPK33.47616527
7TRPM72.90046905
8PRPF4B2.83906772
9FGFR32.45716617
10CDK32.24636908
11EPHA42.23302508
12LATS12.22070780
13MAP3K22.10108025
14FRK2.09827425
15MAP3K32.03283116
16MST1R1.97804683
17FGFR11.93059229
18ERBB31.90743427
19ERN11.88094325
20LRRK21.87529994
21RPS6KB21.85746729
22GRK11.82609238
23EEF2K1.79499711
24MAPK151.61564708
25TNK21.55719156
26MYLK1.51820177
27RPS6KA11.51276560
28STK101.47986948
29MAPK71.45646715
30PIK3CG1.38816639
31TRIB31.31217962
32MAPKAPK51.29504902
33BCR1.28554547
34SIK11.24291754
35PDK21.20559381
36PTK61.16709018
37SMG11.11624469
38NEK91.10602980
39LMTK21.08409051
40MAP2K41.07921155
41MAP3K101.04626869
42ABL20.96608927
43NTRK20.94697360
44RPS6KB10.94237299
45EPHA30.91974375
46PRKCE0.90670170
47DYRK1B0.87894594
48FGFR20.87795325
49DYRK30.87439841
50MAP3K90.85479129
51TTN0.84884112
52PRKAA20.84453359
53MAP2K20.82787490
54MAPKAPK20.80929379
55MAP3K120.80822999
56MET0.79574713
57EPHA20.77980249
58PRKD10.77863808
59ILK0.77332760
60ERBB40.77048175
61KIT0.76463890
62TAOK10.76019999
63FGFR40.74368547
64STK390.69793436
65ACVR1B0.69248895
66TYK20.68750643
67PKN10.67851141
68KSR20.65719707
69BLK0.64816274
70NME20.63835231
71MARK20.63757223
72TAOK30.63394659
73PRKD20.62443705
74ROCK10.62055194
75MAP3K140.61704130
76HIPK20.61493323
77IKBKB0.60338407
78EPHB10.58520849
79IRAK30.57545333
80ADRBK10.56432087
81CSNK1D0.55929478
82MAP2K60.55889802
83CDK60.55776962
84RET0.55571186
85FGR0.55139432
86PIM20.54935502
87MAP3K10.54829339
88RPS6KA20.54456543
89HCK0.54436405
90STK240.54118379
91PAK40.53838368
92MATK0.53397309
93ERBB20.51586399
94MAP2K10.50806148
95AURKA0.50345463
96RIPK40.49828164
97CASK0.49790016
98JAK30.49667634
99RIPK10.49083983
100MAPK40.48708038
101IRAK10.48348658
102OBSCN0.45798447
103CDC42BPA0.45308669
104MAPK110.44328637
105DYRK1A0.43891538
106NEK60.41167049
107STK30.41150338
108BMX0.41036753
109CDK190.40982906
110PDGFRB0.40916110
111PDPK10.38890519
112FYN0.38480735
113NLK0.37045132
114SGK30.36924559
115CSK0.36568151
116JAK10.36071884
117JAK20.35864320
118ITK0.35791093
119MTOR0.35039387
120CAMK1D0.33624948
121MAP3K70.33207004
122CDK50.32870937
123GSK3A0.32764279
124MAPK30.32740450
125MAPK120.32679385
126DDR20.32163131
127PTK20.32112699
128PRKCA0.31871901
129PRKCI0.30791698
130CDK70.30013061
131MAP3K130.29980899
132TESK10.29629983
133SRC0.29374262
134STK110.29328222
135IGF1R0.29276539
136TBK10.28465776
137PAK30.28232263
138LIMK10.28200990
139SGK4940.27784909
140SGK2230.27784909
141MAPK90.27398582
142SGK20.27184621
143LATS20.26828454
144PDGFRA0.26810752
145PBK0.26427461
146PRKACA0.26216230
147GRK60.26178526
148STK38L0.24771494
149PAK20.22127893
150ICK0.21908792
151ABL10.21272578
152PINK10.21114258

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.24891978
2Vitamin digestion and absorption_Homo sapiens_hsa049773.48361847
3Fatty acid elongation_Homo sapiens_hsa000623.14210127
4Linoleic acid metabolism_Homo sapiens_hsa005912.89752748
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86203253
6Graft-versus-host disease_Homo sapiens_hsa053322.79202784
7Fatty acid metabolism_Homo sapiens_hsa012122.72954409
8Sphingolipid metabolism_Homo sapiens_hsa006002.71238660
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.33791730
10Basal cell carcinoma_Homo sapiens_hsa052172.13048288
11Phenylalanine metabolism_Homo sapiens_hsa003602.08187395
12Ribosome_Homo sapiens_hsa030102.02809749
13Steroid biosynthesis_Homo sapiens_hsa001001.91136696
14Collecting duct acid secretion_Homo sapiens_hsa049661.87699357
15Ether lipid metabolism_Homo sapiens_hsa005651.79130610
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66497530
17Histidine metabolism_Homo sapiens_hsa003401.66373124
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60353828
19Melanogenesis_Homo sapiens_hsa049161.58550199
20Arachidonic acid metabolism_Homo sapiens_hsa005901.48600739
21Axon guidance_Homo sapiens_hsa043601.44791723
22Chemical carcinogenesis_Homo sapiens_hsa052041.44469225
23ECM-receptor interaction_Homo sapiens_hsa045121.43237770
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.36602147
25Phototransduction_Homo sapiens_hsa047441.36293277
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36189112
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32586015
28Fat digestion and absorption_Homo sapiens_hsa049751.28459454
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25816741
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23801994
31Proteoglycans in cancer_Homo sapiens_hsa052051.20839224
32Renin secretion_Homo sapiens_hsa049241.18241438
33Tight junction_Homo sapiens_hsa045301.17401070
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.15574716
35Sphingolipid signaling pathway_Homo sapiens_hsa040711.15453356
36Hippo signaling pathway_Homo sapiens_hsa043901.12335518
37Pertussis_Homo sapiens_hsa051331.02864899
38Gastric acid secretion_Homo sapiens_hsa049711.02200730
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02182450
40Tyrosine metabolism_Homo sapiens_hsa003501.01886171
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98642465
42Ovarian steroidogenesis_Homo sapiens_hsa049130.98018052
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97039155
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.94678962
45Antigen processing and presentation_Homo sapiens_hsa046120.94380985
46Hedgehog signaling pathway_Homo sapiens_hsa043400.93802989
47Olfactory transduction_Homo sapiens_hsa047400.93031052
48GnRH signaling pathway_Homo sapiens_hsa049120.90305632
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89277937
50Retinol metabolism_Homo sapiens_hsa008300.88748714
51ABC transporters_Homo sapiens_hsa020100.88555367
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86148845
53Vibrio cholerae infection_Homo sapiens_hsa051100.81709998
54VEGF signaling pathway_Homo sapiens_hsa043700.81600989
55Pyruvate metabolism_Homo sapiens_hsa006200.81283520
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81019431
57Staphylococcus aureus infection_Homo sapiens_hsa051500.80689359
58PPAR signaling pathway_Homo sapiens_hsa033200.78479290
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.78014943
60Mineral absorption_Homo sapiens_hsa049780.76609513
61Pancreatic secretion_Homo sapiens_hsa049720.76285616
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75892089
63Adherens junction_Homo sapiens_hsa045200.75461176
64Ras signaling pathway_Homo sapiens_hsa040140.74951263
65Amphetamine addiction_Homo sapiens_hsa050310.74501427
66Estrogen signaling pathway_Homo sapiens_hsa049150.74201056
67Wnt signaling pathway_Homo sapiens_hsa043100.71776720
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71631811
69Amoebiasis_Homo sapiens_hsa051460.71596091
70Platelet activation_Homo sapiens_hsa046110.71482337
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71340750
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.70133558
73Peroxisome_Homo sapiens_hsa041460.68585274
74Fatty acid biosynthesis_Homo sapiens_hsa000610.68282570
75Rap1 signaling pathway_Homo sapiens_hsa040150.67336085
76beta-Alanine metabolism_Homo sapiens_hsa004100.67159646
77Oxytocin signaling pathway_Homo sapiens_hsa049210.66877737
78TGF-beta signaling pathway_Homo sapiens_hsa043500.66395868
79Renin-angiotensin system_Homo sapiens_hsa046140.66228742
80T cell receptor signaling pathway_Homo sapiens_hsa046600.63828002
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62755105
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61383821
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61173251
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59243749
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.58686260
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58382647
87Protein digestion and absorption_Homo sapiens_hsa049740.58149369
88Cocaine addiction_Homo sapiens_hsa050300.57922397
89Complement and coagulation cascades_Homo sapiens_hsa046100.57737296
90MicroRNAs in cancer_Homo sapiens_hsa052060.56725751
91Serotonergic synapse_Homo sapiens_hsa047260.54929652
92Salivary secretion_Homo sapiens_hsa049700.53393979
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52122841
94Hematopoietic cell lineage_Homo sapiens_hsa046400.51136490
95Rheumatoid arthritis_Homo sapiens_hsa053230.50306410
96Bladder cancer_Homo sapiens_hsa052190.50120431
97Malaria_Homo sapiens_hsa051440.49810027
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49019277
99Tuberculosis_Homo sapiens_hsa051520.46973285
100ErbB signaling pathway_Homo sapiens_hsa040120.46775896
101Circadian entrainment_Homo sapiens_hsa047130.46671075
102Notch signaling pathway_Homo sapiens_hsa043300.46337335
103Long-term depression_Homo sapiens_hsa047300.46188797
104Phagosome_Homo sapiens_hsa041450.45614247
105Long-term potentiation_Homo sapiens_hsa047200.41851177
106cAMP signaling pathway_Homo sapiens_hsa040240.41777182
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40294756
108Fatty acid degradation_Homo sapiens_hsa000710.39891852
109Glutamatergic synapse_Homo sapiens_hsa047240.39462953
110Lysosome_Homo sapiens_hsa041420.39176424
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38684095
112Glioma_Homo sapiens_hsa052140.38240042
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38108491
114Hepatitis C_Homo sapiens_hsa051600.37746508
115Cholinergic synapse_Homo sapiens_hsa047250.37065641
116Glycerolipid metabolism_Homo sapiens_hsa005610.36582179
117Calcium signaling pathway_Homo sapiens_hsa040200.36299111
118Acute myeloid leukemia_Homo sapiens_hsa052210.35964499
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35115328
120Choline metabolism in cancer_Homo sapiens_hsa052310.35100949
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.34713901
122Insulin signaling pathway_Homo sapiens_hsa049100.34246364
123Nitrogen metabolism_Homo sapiens_hsa009100.30702671
124Thyroid cancer_Homo sapiens_hsa052160.29244375
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29158709
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.28678080
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24770958
128Propanoate metabolism_Homo sapiens_hsa006400.22528986
129Carbon metabolism_Homo sapiens_hsa012000.20490156
130Tryptophan metabolism_Homo sapiens_hsa003800.19651307
131Glucagon signaling pathway_Homo sapiens_hsa049220.18823516
132Dorso-ventral axis formation_Homo sapiens_hsa043200.18649622
133Circadian rhythm_Homo sapiens_hsa047100.17241682
134Focal adhesion_Homo sapiens_hsa045100.16594542
135Toxoplasmosis_Homo sapiens_hsa051450.14813375
136Arginine biosynthesis_Homo sapiens_hsa002200.13009192
137Salmonella infection_Homo sapiens_hsa051320.10741806

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