KRT80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.69812326
2peptide cross-linking (GO:0018149)8.17611772
3multicellular organismal water homeostasis (GO:0050891)7.71387166
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)7.27304091
5keratinocyte differentiation (GO:0030216)7.15520349
6regulation of cell proliferation involved in kidney development (GO:1901722)6.65206087
7hepatocyte apoptotic process (GO:0097284)6.40004713
8water homeostasis (GO:0030104)6.37386254
9intermediate filament organization (GO:0045109)6.11509176
10skin morphogenesis (GO:0043589)6.11472457
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.68522932
12positive regulation of keratinocyte differentiation (GO:0045618)5.55527177
13epidermal cell differentiation (GO:0009913)5.35324533
14regulation of apoptotic process involved in morphogenesis (GO:1902337)5.31112684
15lipoxygenase pathway (GO:0019372)4.89096708
16branching involved in salivary gland morphogenesis (GO:0060445)4.82284221
17epidermis development (GO:0008544)4.80662778
18Golgi transport vesicle coating (GO:0048200)4.75450411
19COPI coating of Golgi vesicle (GO:0048205)4.75450411
20long-chain fatty acid biosynthetic process (GO:0042759)4.74630392
21surfactant homeostasis (GO:0043129)4.73139251
22cell proliferation involved in metanephros development (GO:0072203)4.66718343
23positive regulation of epidermal cell differentiation (GO:0045606)4.63087420
24mesonephros development (GO:0001823)4.61942472
25adhesion of symbiont to host cell (GO:0044650)4.40691579
26virion attachment to host cell (GO:0019062)4.40691579
27embryonic eye morphogenesis (GO:0048048)4.18923137
28negative regulation of kidney development (GO:0090185)4.14355053
29intestinal epithelial cell development (GO:0060576)4.12225519
30embryonic camera-type eye morphogenesis (GO:0048596)4.06507133
31positive regulation of Cdc42 GTPase activity (GO:0043089)3.95447363
32cell-substrate junction assembly (GO:0007044)3.95218881
33ectoderm development (GO:0007398)3.94273290
34regulation of keratinocyte differentiation (GO:0045616)3.89721657
35intermediate filament cytoskeleton organization (GO:0045104)3.84900766
36regulation of glomerulus development (GO:0090192)3.81451337
37intermediate filament-based process (GO:0045103)3.71740506
38adhesion of symbiont to host (GO:0044406)3.71123022
39striated muscle atrophy (GO:0014891)3.69570886
40chemical homeostasis within a tissue (GO:0048875)3.67529138
41embryonic skeletal joint morphogenesis (GO:0060272)3.62798472
42cell-substrate adherens junction assembly (GO:0007045)3.59754766
43focal adhesion assembly (GO:0048041)3.59754766
44cell proliferation involved in kidney development (GO:0072111)3.52698781
45epithelial cell-cell adhesion (GO:0090136)3.51767898
46apoptotic cell clearance (GO:0043277)3.50790181
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.44846138
48ear development (GO:0043583)3.33442950
49branching involved in mammary gland duct morphogenesis (GO:0060444)3.32541777
50cell differentiation involved in embryonic placenta development (GO:0060706)3.32323047
51citrulline biosynthetic process (GO:0019240)3.31849204
52muscle atrophy (GO:0014889)3.28549076
53gap junction assembly (GO:0016264)3.27061524
54cytoskeletal anchoring at plasma membrane (GO:0007016)3.26853458
55negative regulation of stress fiber assembly (GO:0051497)3.23641061
56activation of Rac GTPase activity (GO:0032863)3.23140507
57adherens junction assembly (GO:0034333)3.20659887
58regulation of cardioblast differentiation (GO:0051890)3.19607769
59cardiac right ventricle morphogenesis (GO:0003215)3.18850935
60negative regulation of cell fate specification (GO:0009996)3.18834362
61negative regulation of striated muscle cell apoptotic process (GO:0010664)3.18359664
62planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13626896
63mesenchyme morphogenesis (GO:0072132)3.12205042
64skin development (GO:0043588)3.12190604
65negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.10344736
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10280864
67atrioventricular valve morphogenesis (GO:0003181)3.08354229
68response to water (GO:0009415)3.06270692
69protein localization to endosome (GO:0036010)3.05571595
70keratinocyte proliferation (GO:0043616)3.05244831
71protein localization to microtubule (GO:0035372)3.01698563
72negative regulation of cell size (GO:0045792)3.01354234
73regulation of integrin activation (GO:0033623)3.01113595
74response to vitamin D (GO:0033280)2.97988455
75regulation of transforming growth factor beta2 production (GO:0032909)2.97855533
76regulation of mesenchymal cell apoptotic process (GO:2001053)2.94674719
77regulation of histone H3-K27 methylation (GO:0061085)2.94548519
78epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94483504
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94330286
80maternal placenta development (GO:0001893)2.94178602
81norepinephrine metabolic process (GO:0042415)2.94147811
82regulation of apoptotic cell clearance (GO:2000425)2.92158447
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88017606
84ER overload response (GO:0006983)2.87181613
85linoleic acid metabolic process (GO:0043651)2.82296996
86regulation of endothelial cell chemotaxis (GO:2001026)2.80768065
87regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.80385923
88tight junction assembly (GO:0070830)2.80367790
89glucosamine-containing compound catabolic process (GO:1901072)2.79535577
90glucose 6-phosphate metabolic process (GO:0051156)2.78657233
91protein retention in ER lumen (GO:0006621)2.76970649
92regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76293781
93endothelial cell chemotaxis (GO:0035767)2.74925018
94regulation of epidermal cell differentiation (GO:0045604)2.74874785
95face development (GO:0060324)2.73326051
96nuclear envelope reassembly (GO:0031468)2.72028631
97mitotic nuclear envelope reassembly (GO:0007084)2.72028631
98eyelid development in camera-type eye (GO:0061029)2.71948581
99leukocyte aggregation (GO:0070486)2.69601969
100lymph vessel development (GO:0001945)2.68082207
101response to food (GO:0032094)2.68048747
102hair follicle morphogenesis (GO:0031069)2.68017730
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65707051
104fibrinolysis (GO:0042730)2.63665824
105pentose-phosphate shunt (GO:0006098)2.62025297
106regulation of hippo signaling (GO:0035330)2.61969267
107negative regulation of embryonic development (GO:0045992)2.61583815
108establishment of protein localization to plasma membrane (GO:0090002)2.61105989
109regulation of centriole replication (GO:0046599)2.59710528
110regulation of epidermis development (GO:0045682)2.58948859
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57918062
112regulation of ruffle assembly (GO:1900027)2.57845213
113cell-cell junction assembly (GO:0007043)2.56236255
114mesoderm formation (GO:0001707)2.55578477
115wound healing, spreading of epidermal cells (GO:0035313)2.50798368
116negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.48401822
117endodermal cell differentiation (GO:0035987)2.47526544
118phospholipid scrambling (GO:0017121)2.44621822
119negative regulation of cardiac muscle tissue growth (GO:0055022)2.42144019
120negative regulation of heart growth (GO:0061117)2.42144019
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41525033
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40124053
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40124053
124sphingosine metabolic process (GO:0006670)2.39870988
125wound healing (GO:0042060)2.37276708
126dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.36011679
127epithelium development (GO:0060429)2.35745807
128regulation of monocyte chemotaxis (GO:0090025)2.34744064
129hormone catabolic process (GO:0042447)2.34722678
130phosphatidylinositol acyl-chain remodeling (GO:0036149)2.34639046
131antigen processing and presentation of endogenous antigen (GO:0019883)2.33115941
132fatty acid elongation (GO:0030497)2.32825210
133positive regulation of monocyte chemotaxis (GO:0090026)2.32644399
134mesodermal cell differentiation (GO:0048333)2.30145305
135positive regulation of epidermis development (GO:0045684)2.28010360
136negative regulation of keratinocyte proliferation (GO:0010839)2.26794565
137peptide catabolic process (GO:0043171)2.25161247
138cell adhesion mediated by integrin (GO:0033627)2.24028009
139negative regulation of erythrocyte differentiation (GO:0045647)2.22595631
140ventricular cardiac muscle cell action potential (GO:0086005)2.21996971
141keratinocyte development (GO:0003334)2.21407575
142gland morphogenesis (GO:0022612)2.21155322
143molting cycle process (GO:0022404)2.17891190
144hair cycle process (GO:0022405)2.17891190
145vascular endothelial growth factor signaling pathway (GO:0038084)2.17880429
146skeletal muscle adaptation (GO:0043501)2.15677605
147lung lobe morphogenesis (GO:0060463)2.14749976
148complement activation, alternative pathway (GO:0006957)2.13677789
149positive regulation of cholesterol efflux (GO:0010875)2.13396195
150positive regulation of hair cycle (GO:0042635)2.13269630
151positive regulation of hair follicle development (GO:0051798)2.13269630
152basement membrane organization (GO:0071711)2.12259950
153embryonic camera-type eye development (GO:0031076)2.11482869
154regulation of cell fate specification (GO:0042659)2.10924767
155negative regulation of actin filament bundle assembly (GO:0032232)2.10298288
156regulation of vasculogenesis (GO:2001212)2.10014171
157primary alcohol catabolic process (GO:0034310)2.09919141
158regulation of macrophage chemotaxis (GO:0010758)2.09868910
159coronary vasculature morphogenesis (GO:0060977)2.09849349
160regulation of skeletal muscle contraction (GO:0014819)2.08752346
161plasma membrane repair (GO:0001778)2.08563966
162establishment of apical/basal cell polarity (GO:0035089)2.07500918
163stress fiber assembly (GO:0043149)2.06589262
164positive regulation of p38MAPK cascade (GO:1900745)2.06469603
165keratinization (GO:0031424)15.5891218
166establishment of skin barrier (GO:0061436)12.2050149
167molting cycle (GO:0042303)11.9843778
168hair cycle (GO:0042633)11.9843778
169regulation of water loss via skin (GO:0033561)10.8340077
170desmosome organization (GO:0002934)10.4053336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53905528
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.05273957
3ESR1_15608294_ChIP-ChIP_MCF-7_Human2.75863372
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64753753
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.36886148
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.22030262
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20216041
8ZNF263_19887448_ChIP-Seq_K562_Human2.18986135
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.13121468
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11372933
11TP63_17297297_ChIP-ChIP_HaCaT_Human11.8569208
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.91689173
13* RACK7_27058665_Chip-Seq_MCF-7_Human1.85702272
14* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82101954
15* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82101954
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79918477
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77552520
18LXR_22292898_ChIP-Seq_THP-1_Human1.76582106
19AHR_22903824_ChIP-Seq_MCF-7_Human1.75871375
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71954800
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70436938
22CLOCK_20551151_ChIP-Seq_293T_Human1.69139503
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.68714370
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64932694
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64733481
26* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61233190
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54283853
28* ATF3_27146783_Chip-Seq_COLON_Human1.53866384
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52937106
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.50476146
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49836103
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48185780
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43461130
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41213936
35* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39609419
36TP63_22573176_ChIP-Seq_HFKS_Human1.39432226
37* RUNX1_27514584_Chip-Seq_MCF-7_Human1.37620443
38TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35975807
39KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35913799
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35631329
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35469593
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34152456
43AR_21909140_ChIP-Seq_LNCAP_Human1.33630071
44SOX2_20726797_ChIP-Seq_SW620_Human1.32661891
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29041766
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28270726
47* GATA2_21666600_ChIP-Seq_HMVEC_Human1.28208432
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27526871
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26803804
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26724189
51KDM2B_26808549_Chip-Seq_DND41_Human1.26361297
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25485967
53* CJUN_26792858_Chip-Seq_BT549_Human1.24604635
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24532135
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.24208948
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22730868
57BCOR_27268052_Chip-Seq_Bcells_Human1.21203522
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21097500
59UBF1/2_26484160_Chip-Seq_HMECs_Human1.20507378
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18647159
61* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18280937
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18158429
63ELF5_23300383_ChIP-Seq_T47D_Human1.17788126
64TCF7_22412390_ChIP-Seq_EML_Mouse1.17780074
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16950515
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16902885
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.16721291
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16691115
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15769366
70* KLF5_25053715_ChIP-Seq_YYC3_Human1.15708054
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15336922
72* TP63_23658742_ChIP-Seq_EP156T_Human1.12986654
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12673678
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12004483
75P68_20966046_ChIP-Seq_HELA_Human1.11999226
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10873208
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10052485
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09689065
79P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09684589
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08117013
81* GATA3_24758297_ChIP-Seq_MCF-7_Human1.07881060
82CTCF_20526341_ChIP-Seq_ESCs_Human1.07336670
83CHD1_26751641_Chip-Seq_LNCaP_Human1.06280825
84KDM2B_26808549_Chip-Seq_K562_Human1.05923346
85E2F1_20622854_ChIP-Seq_HELA_Human1.05587993
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05419132
87* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05170043
88BCL6_27268052_Chip-Seq_Bcells_Human1.04466672
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03855147
90* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03207168
91* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01599055
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.01474912
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01375832
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01290195
95CTCF_27219007_Chip-Seq_Bcells_Human1.01258529
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.00469489
97NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99576756
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99546192
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.99168426
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.99168426
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.98338258
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97784711
103CREB1_26743006_Chip-Seq_LNCaP_Human0.97491265
104EGR1_19032775_ChIP-ChIP_M12_Human0.96821016
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96788648
106MYC_22102868_ChIP-Seq_BL_Human0.95944400
107GATA4_25053715_ChIP-Seq_YYC3_Human0.95764353
108* GATA6_25053715_ChIP-Seq_YYC3_Human0.95583112
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.95501266
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95227182
111* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95135570
112DCP1A_22483619_ChIP-Seq_HELA_Human0.94951675
113* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93287275
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93237312
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92075845
116KDM5A_27292631_Chip-Seq_BREAST_Human0.91683462
117CSB_26484114_Chip-Seq_FIBROBLAST_Human0.91601646
118E2F7_22180533_ChIP-Seq_HELA_Human0.90488274
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89794183
120VDR_21846776_ChIP-Seq_THP-1_Human0.89250000
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.89166325
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89083990
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88377428
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88349065
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88249549
126MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87329944
127SPI1_20517297_ChIP-Seq_HL60_Human0.87050572
128RXR_22108803_ChIP-Seq_LS180_Human0.86877047
129TP53_22127205_ChIP-Seq_IMR90_Human0.86826904
130GATA2_19941826_ChIP-Seq_K562_Human0.86447222
131SMC4_20622854_ChIP-Seq_HELA_Human0.86141215
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86117506
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.85602494
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.85456935
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.84869404
136GATA1_19941826_ChIP-Seq_K562_Human0.83633179
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83493423
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82985519
139ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82433218
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81943571
141GATA6_21074721_ChIP-Seq_CACO-2_Human0.81217313
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.80967239
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80100258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.31659556
2MP0005275_abnormal_skin_tensile6.98521954
3MP0000579_abnormal_nail_morphology4.86228096
4MP0005501_abnormal_skin_physiology4.51059199
5MP0003705_abnormal_hypodermis_morpholog4.20261180
6MP0010234_abnormal_vibrissa_follicle3.68198399
7MP0002060_abnormal_skin_morphology3.22811086
8MP0004947_skin_inflammation3.07236911
9MP0001216_abnormal_epidermal_layer3.07116484
10MP0000647_abnormal_sebaceous_gland2.92910368
11MP0002254_reproductive_system_inflammat2.82290164
12MP0002098_abnormal_vibrissa_morphology2.71431237
13MP0010771_integument_phenotype2.70589453
14MP0000383_abnormal_hair_follicle2.61369964
15MP0003566_abnormal_cell_adhesion2.49635355
16MP0003453_abnormal_keratinocyte_physiol2.45473128
17MP0010678_abnormal_skin_adnexa2.34689715
18MP0000377_abnormal_hair_follicle2.33846506
19MP0003941_abnormal_skin_development2.29701598
20MP0004233_abnormal_muscle_weight2.21189827
21MP0000467_abnormal_esophagus_morphology2.15433416
22MP0000427_abnormal_hair_cycle1.99980066
23MP0009780_abnormal_chondrocyte_physiolo1.99923166
24MP0008438_abnormal_cutaneous_collagen1.88253806
25MP0004381_abnormal_hair_follicle1.79948896
26MP0001243_abnormal_dermal_layer1.74596167
27MP0009931_abnormal_skin_appearance1.73038850
28MP0002249_abnormal_larynx_morphology1.69889014
29MP0003191_abnormal_cellular_cholesterol1.69342530
30MP0000762_abnormal_tongue_morphology1.61247897
31MP0000462_abnormal_digestive_system1.59629699
32MP0004185_abnormal_adipocyte_glucose1.45115393
33MP0001191_abnormal_skin_condition1.41446069
34MP0002234_abnormal_pharynx_morphology1.41059344
35MP0000367_abnormal_coat/_hair1.38190747
36MP0001958_emphysema1.36745371
37MP0004782_abnormal_surfactant_physiolog1.35188293
38MP0005023_abnormal_wound_healing1.31961076
39MP0001851_eye_inflammation1.30379741
40MP0001348_abnormal_lacrimal_gland1.27945103
41MP0001849_ear_inflammation1.27403772
42MP0000534_abnormal_ureter_morphology1.22608400
43MP0001873_stomach_inflammation1.19190496
44MP0000465_gastrointestinal_hemorrhage1.17320123
45MP0002877_abnormal_melanocyte_morpholog1.14506127
46MP0003123_paternal_imprinting1.11052399
47MP0005451_abnormal_body_composition1.09830346
48MP0001188_hyperpigmentation1.04369703
49MP0003942_abnormal_urinary_system1.02417883
50MP0009053_abnormal_anal_canal0.99584555
51MP0000003_abnormal_adipose_tissue0.99576740
52MP0010030_abnormal_orbit_morphology0.98824718
53MP0010368_abnormal_lymphatic_system0.96091851
54MP0009379_abnormal_foot_pigmentation0.95908068
55MP0010352_gastrointestinal_tract_polyps0.95773543
56MP0003436_decreased_susceptibility_to0.95123228
57MP0008260_abnormal_autophagy0.90330538
58MP0004272_abnormal_basement_membrane0.90301211
59MP0005076_abnormal_cell_differentiation0.86902203
60MP0001881_abnormal_mammary_gland0.83491464
61MP0006054_spinal_hemorrhage0.82748567
62MP0005257_abnormal_intraocular_pressure0.81542135
63MP0005408_hypopigmentation0.80370075
64MP0009672_abnormal_birth_weight0.79850413
65MP0003878_abnormal_ear_physiology0.79438399
66MP0005377_hearing/vestibular/ear_phenot0.79438399
67MP0000678_abnormal_parathyroid_gland0.78869605
68MP0001879_abnormal_lymphatic_vessel0.78580066
69MP0004197_abnormal_fetal_growth/weight/0.77844919
70MP0000858_altered_metastatic_potential0.76180892
71MP0002166_altered_tumor_susceptibility0.75939003
72MP0004957_abnormal_blastocyst_morpholog0.75909304
73MP0001784_abnormal_fluid_regulation0.75332986
74MP0003075_altered_response_to0.73390993
75MP0002095_abnormal_skin_pigmentation0.73289486
76MP0008004_abnormal_stomach_pH0.72522531
77MP0003693_abnormal_embryo_hatching0.72512173
78MP0002697_abnormal_eye_size0.68727905
79MP0002282_abnormal_trachea_morphology0.67880646
80MP0001346_abnormal_lacrimal_gland0.67681161
81MP0003300_gastrointestinal_ulcer0.66992629
82MP0009278_abnormal_bone_marrow0.66961410
83MP0005083_abnormal_biliary_tract0.66886018
84MP0003448_altered_tumor_morphology0.66429595
85MP0000343_altered_response_to0.65560401
86MP0001533_abnormal_skeleton_physiology0.65087624
87MP0003303_peritoneal_inflammation0.64105540
88MP0002138_abnormal_hepatobiliary_system0.63969277
89MP0005375_adipose_tissue_phenotype0.63763581
90MP0002086_abnormal_extraembryonic_tissu0.63628256
91MP0000685_abnormal_immune_system0.63435154
92MP0002909_abnormal_adrenal_gland0.63393367
93MP0001727_abnormal_embryo_implantation0.63345414
94MP0000733_abnormal_muscle_development0.61022099
95MP0003755_abnormal_palate_morphology0.60936283
96MP0002111_abnormal_tail_morphology0.60897353
97MP0003936_abnormal_reproductive_system0.60068083
98MP0002092_abnormal_eye_morphology0.59464984
99MP0002080_prenatal_lethality0.59127944
100MP0003279_aneurysm0.59110537
101MP0005621_abnormal_cell_physiology0.58360905
102MP0004858_abnormal_nervous_system0.58248853
103MP0003115_abnormal_respiratory_system0.57504627
104MP0009384_cardiac_valve_regurgitation0.56948144
105MP0002089_abnormal_postnatal_growth/wei0.56650313
106MP0008961_abnormal_basal_metabolism0.54273325
107MP0005508_abnormal_skeleton_morphology0.54058751
108MP0003724_increased_susceptibility_to0.54010547
109MP0002006_tumorigenesis0.53501401
110MP0001697_abnormal_embryo_size0.52987792
111MP0000627_abnormal_mammary_gland0.52611857
112MP0001672_abnormal_embryogenesis/_devel0.52242815
113MP0005380_embryogenesis_phenotype0.52242815
114MP0000566_synostosis0.52095784
115MP0001340_abnormal_eyelid_morphology0.51921727
116MP0009840_abnormal_foam_cell0.51883519
117MP0001666_abnormal_nutrient_absorption0.51674133
118MP0000470_abnormal_stomach_morphology0.50494146
119MP0001730_embryonic_growth_arrest0.50201897
120MP0003984_embryonic_growth_retardation0.49971144
121MP0000767_abnormal_smooth_muscle0.49695578
122MP0002088_abnormal_embryonic_growth/wei0.49678194
123MP0009333_abnormal_splenocyte_physiolog0.49636672
124MP0003045_fibrosis0.49409085
125MP0000350_abnormal_cell_proliferation0.48834513
126MP0000537_abnormal_urethra_morphology0.48649223
127MP0002085_abnormal_embryonic_tissue0.48002277
128MP0000750_abnormal_muscle_regeneration0.47482314
129MP0003950_abnormal_plasma_membrane0.46588750
130MP0005388_respiratory_system_phenotype0.45927296
131MP0002133_abnormal_respiratory_system0.45927296
132MP0002177_abnormal_outer_ear0.45862634
133MP0000749_muscle_degeneration0.45621587
134MP0005387_immune_system_phenotype0.45236021
135MP0001790_abnormal_immune_system0.45236021
136MP0005167_abnormal_blood-brain_barrier0.45133822
137MP0000751_myopathy0.43952588
138MP0003638_abnormal_response/metabolism_0.43702422
139MP0005058_abnormal_lysosome_morphology0.42856708
140MP0003091_abnormal_cell_migration0.42800609
141MP0005409_darkened_coat_color0.42471136
142MP0005025_abnormal_response_to0.42467700
143MP0004264_abnormal_extraembryonic_tissu0.41960574
144MP0005666_abnormal_adipose_tissue0.39483065
145MP0004087_abnormal_muscle_fiber0.38553119
146MP0005248_abnormal_Harderian_gland0.38361665
147MP0004510_myositis0.38347752
148MP0005397_hematopoietic_system_phenotyp0.38052438
149MP0001545_abnormal_hematopoietic_system0.38052438
150MP0005390_skeleton_phenotype0.37386375
151MP0005464_abnormal_platelet_physiology0.34433515

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.89572792
2Hypotrichosis (HP:0001006)7.25438320
3Palmoplantar hyperkeratosis (HP:0000972)6.56201777
4Plantar hyperkeratosis (HP:0007556)6.51149148
5Conjunctival hamartoma (HP:0100780)6.40920932
6Palmar hyperkeratosis (HP:0010765)6.17176731
7Abnormality of nail color (HP:0100643)5.98305680
8Woolly hair (HP:0002224)5.88224463
9Onycholysis (HP:0001806)5.85660758
10Thick nail (HP:0001805)5.48171455
11Pili torti (HP:0003777)5.26915934
12Right ventricular cardiomyopathy (HP:0011663)5.18174615
13Milia (HP:0001056)4.98665294
14Erythema (HP:0010783)4.78044242
15Fragile nails (HP:0001808)4.58146641
16Erythroderma (HP:0001019)4.55049215
17Micronodular cirrhosis (HP:0001413)4.38532674
18Nail dystrophy (HP:0008404)4.25738708
19Alopecia of scalp (HP:0002293)4.19723055
20J-shaped sella turcica (HP:0002680)4.18425584
21Hamartoma of the eye (HP:0010568)4.17307070
22Abnormal blistering of the skin (HP:0008066)4.01147231
23Absent frontal sinuses (HP:0002688)3.94119557
24Congenital ichthyosiform erythroderma (HP:0007431)3.90007230
25Septate vagina (HP:0001153)3.63707843
26Eczematoid dermatitis (HP:0000976)3.58470109
27Broad face (HP:0000283)3.48591970
28Asymmetry of the thorax (HP:0001555)3.35078793
29Gangrene (HP:0100758)3.33241681
30Atrophic scars (HP:0001075)3.30034536
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.19716167
32Abnormal hair laboratory examination (HP:0003328)3.17646880
33Microglossia (HP:0000171)3.17393828
34Follicular hyperkeratosis (HP:0007502)3.12470776
35Corneal erosion (HP:0200020)3.02811413
36Abnormality of the frontal sinuses (HP:0002687)2.99938615
37Palmoplantar keratoderma (HP:0000982)2.94904535
38Hyperacusis (HP:0010780)2.92784298
39Increased connective tissue (HP:0009025)2.88487577
40Selective tooth agenesis (HP:0001592)2.88433477
41Ectropion (HP:0000656)2.86053212
42Hyporeflexia of lower limbs (HP:0002600)2.78735498
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77455214
44Ventricular tachycardia (HP:0004756)2.75101515
45Curly hair (HP:0002212)2.73423994
46Type 1 muscle fiber predominance (HP:0003803)2.72075810
47Short nail (HP:0001799)2.70957283
48Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.62743049
49Oral leukoplakia (HP:0002745)2.56762867
50Deformed sella turcica (HP:0002681)2.55348629
51Advanced eruption of teeth (HP:0006288)2.53947797
52Arterial tortuosity (HP:0005116)2.51884066
53Round ear (HP:0100830)2.51858894
54Abdominal distention (HP:0003270)2.51475228
55Esophageal varix (HP:0002040)2.50752412
56Systemic lupus erythematosus (HP:0002725)2.48250612
57Abnormality of the distal phalanges of the toes (HP:0010182)2.47865744
58Fatigable weakness (HP:0003473)2.44663453
59Abnormality of the neuromuscular junction (HP:0003398)2.44663453
60Hypergammaglobulinemia (HP:0010702)2.43879769
61Hyperparathyroidism (HP:0000843)2.36677031
62Ridged nail (HP:0001807)2.32932268
63Distal lower limb muscle weakness (HP:0009053)2.31493575
64Cerebral aneurysm (HP:0004944)2.31429402
65Interstitial pulmonary disease (HP:0006530)2.31344322
66Natal tooth (HP:0000695)2.30789442
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.29826029
68Osteolytic defects of the hand bones (HP:0009699)2.29826029
69Ulnar deviation of the wrist (HP:0003049)2.28282731
70Concave nail (HP:0001598)2.24814710
71Abnormality of the salivary glands (HP:0010286)2.23482980
72Pruritus (HP:0000989)2.18421385
73Pterygium (HP:0001059)2.17276715
74Pustule (HP:0200039)2.16124486
75Sparse eyelashes (HP:0000653)2.15599791
76Hypohidrosis (HP:0000966)2.15355244
77Distal arthrogryposis (HP:0005684)2.12906004
78Abnormality of the umbilical cord (HP:0010881)2.12742304
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11587490
80Fragile skin (HP:0001030)2.10772729
81Shallow orbits (HP:0000586)2.10198253
82Slow-growing hair (HP:0002217)2.09377208
83Abnormality of hair growth rate (HP:0011363)2.09377208
84Abnormality of the nasal mucosa (HP:0000433)2.08220270
85Muscle fiber inclusion bodies (HP:0100299)2.07953430
86Trismus (HP:0000211)2.07239853
87Lack of skin elasticity (HP:0100679)2.05319655
88Skin ulcer (HP:0200042)2.05065179
89Nemaline bodies (HP:0003798)2.04543339
90Blepharitis (HP:0000498)2.01008619
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00926260
92Vascular tortuosity (HP:0004948)2.00514506
93Lip pit (HP:0100267)1.99946383
94Popliteal pterygium (HP:0009756)1.99191782
95Absent eyelashes (HP:0000561)1.97592044
96Verrucae (HP:0200043)1.97468098
97Papilloma (HP:0012740)1.97468098
98Flat acetabular roof (HP:0003180)1.97340334
99Peritonitis (HP:0002586)1.95905513
100Thin bony cortex (HP:0002753)1.95418504
101Spinal cord compression (HP:0002176)1.95404421
102Deviation of the thumb (HP:0009603)1.95175618
103Abnormalities of placenta or umbilical cord (HP:0001194)1.94122906
104Ulnar bowing (HP:0003031)1.94115479
105Brittle hair (HP:0002299)1.92763183
106Acanthosis nigricans (HP:0000956)1.92560324
107Hematochezia (HP:0002573)1.88769079
108Hamartoma (HP:0010566)1.85332110
109Spondylolisthesis (HP:0003302)1.85060220
110Axonal loss (HP:0003447)1.84974830
111Premature rupture of membranes (HP:0001788)1.84121125
112Upper limb amyotrophy (HP:0009129)1.81960911
113Distal upper limb amyotrophy (HP:0007149)1.81960911
114Muscle fiber splitting (HP:0003555)1.81928632
115Vertebral compression fractures (HP:0002953)1.80585040
116Abnormality of the gastric mucosa (HP:0004295)1.80178400
117Macroorchidism (HP:0000053)1.78504547
118Abnormality of complement system (HP:0005339)1.78500974
119Germ cell neoplasia (HP:0100728)1.77897049
120Abnormality of the sella turcica (HP:0002679)1.77783687
121Long toe (HP:0010511)1.77319090
122Sparse lateral eyebrow (HP:0005338)1.76652186
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.76505891
124Unilateral renal agenesis (HP:0000122)1.76438066
125Laryngomalacia (HP:0001601)1.75661418
126Achilles tendon contracture (HP:0001771)1.73346566
127Progressive sensorineural hearing impairment (HP:0000408)1.72996273
128Anonychia (HP:0001798)1.72461382
129Proximal placement of thumb (HP:0009623)1.72030303
130Abnormality of placental membranes (HP:0011409)1.71730375
131Amniotic constriction ring (HP:0009775)1.71730375
132Abnormality of permanent molar morphology (HP:0011071)1.71477356
133Abnormality of the dental root (HP:0006486)1.71477356
134Taurodontia (HP:0000679)1.71477356
135Broad metatarsal (HP:0001783)1.70414418
136Melanocytic nevus (HP:0000995)1.70085344
137Buphthalmos (HP:0000557)1.68264820
138Bronchomalacia (HP:0002780)1.67815457
139Aplasia cutis congenita (HP:0001057)1.67387781
140Myopathic facies (HP:0002058)1.67304088
141Mildly elevated creatine phosphokinase (HP:0008180)1.67146308
142Parakeratosis (HP:0001036)1.66423870
143Neonatal death (HP:0003811)1.66390588
144Neck muscle weakness (HP:0000467)1.64927661
145Spinal rigidity (HP:0003306)1.61484208
146Hyperhidrosis (HP:0000975)1.60343888
147Polycythemia (HP:0001901)1.60104958
148Distal lower limb amyotrophy (HP:0008944)1.60077864
149Frequent falls (HP:0002359)1.57884046
150Wrist flexion contracture (HP:0001239)1.57678114
151Calcaneovalgus deformity (HP:0001848)1.57488309
152Scapular winging (HP:0003691)1.57315885
153Abnormality of skeletal muscle fiber size (HP:0012084)1.56790634
154Abnormality of the calcaneus (HP:0008364)1.53771544
155Protrusio acetabuli (HP:0003179)1.51012979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.83447240
2TRIB33.50622957
3ERN13.43934721
4TTN3.27624442
5MAPKAPK33.24811286
6SCYL23.06125281
7EPHA22.94712990
8IRAK32.71006145
9FER2.62255624
10MAP3K32.60895326
11NME22.40973860
12SMG12.32281773
13TIE12.31111973
14RIPK12.28446489
15MAP3K122.28190887
16TGFBR22.25130147
17EPHB12.20206374
18PIK3CA2.13559708
19EPHB22.12304050
20MUSK2.06284034
21MAP3K112.06253811
22MAP2K31.99824911
23EEF2K1.96074019
24SIK31.91718838
25LRRK21.84953077
26TAOK11.79910816
27MET1.79825185
28PKN21.68855610
29PIK3CG1.68014066
30FGFR11.66516732
31TRPM71.65978522
32LATS11.65350219
33PTK61.64132653
34STK101.60479443
35NEK61.54654046
36BLK1.51895309
37RPS6KB21.51780465
38EIF2AK11.51431641
39BMX1.46594775
40MAP3K61.34859278
41CDK81.34136141
42TESK21.32891717
43MAP3K21.30025604
44LMTK21.28704423
45PTK21.27732986
46DDR21.26260050
47PDGFRA1.21353162
48MST41.19715184
49FGR1.19557771
50PIM21.16713685
51RPS6KA41.14988043
52CSK1.13896931
53PAK41.08694595
54DYRK1B1.02496588
55VRK21.02337033
56MAP4K11.02304836
57CAMK2B1.02285956
58CAMK2G0.99172688
59FGFR40.97977540
60CDK120.95940432
61MAP3K10.91188444
62MAPKAPK20.89468868
63CDK60.84202195
64CAMK2D0.83270876
65MAP3K70.82871536
66TYK20.81188396
67CDK70.79875977
68PRKD20.79424439
69KSR20.79254941
70PRKCI0.78466909
71EPHA30.77108115
72MATK0.76845362
73CHUK0.76191938
74ILK0.74236964
75MAP3K90.72360521
76TRIM280.72334459
77HCK0.71240239
78MELK0.70946539
79STK380.69661681
80PRKD10.69063100
81PBK0.68172829
82TESK10.66929355
83DMPK0.65996925
84MAP2K60.65519977
85OBSCN0.65103198
86FGFR30.64778578
87MYLK0.64474832
88IRAK20.63154729
89MAP2K10.62656055
90FGFR20.61800013
91LATS20.59047832
92ERBB30.57903329
93CAMK1D0.57814825
94ZAP700.57090064
95TGFBR10.57063831
96PDPK10.54850553
97ICK0.53111959
98CDK90.49932620
99SIK10.48817642
100PDGFRB0.48151079
101ITK0.47691891
102MAP2K20.46220029
103RPS6KB10.46080446
104NEK10.46067364
105ARAF0.46030031
106MAP3K100.45687058
107TAOK20.43047660
108BTK0.42977403
109KSR10.42286602
110STK240.42144595
111ERBB40.41819362
112GSK3A0.41731537
113EGFR0.41622726
114AURKB0.41264149
115PRKCH0.41240467
116RPS6KL10.40634556
117RPS6KC10.40634556
118JAK10.40373131
119MAPKAPK50.39244945
120TSSK60.39004515
121TAOK30.38849734
122PAK20.38781573
123LIMK10.37684553
124RPS6KA60.37077281
125MAPK150.36535061
126TYRO30.35335655
127MAP3K80.35280489
128RPS6KA10.35062349
129PRPF4B0.33307345
130AURKA0.31370662
131RET0.30985929
132DAPK10.30627274
133ROCK20.30227344
134TBK10.29864825
135JAK20.29141216
136JAK30.28428799
137STK30.28408549
138PRKG20.28219656
139NME10.27972613
140MTOR0.27524277
141ABL20.27472060
142RPS6KA20.26873692
143PRKD30.26134830
144BUB10.25692900
145NTRK10.23142741
146AKT20.22921122
147SRPK10.21407350
148EIF2AK30.20594268
149BRSK10.20449792
150EIF2AK20.20345324

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.72813002
2Pentose phosphate pathway_Homo sapiens_hsa000302.17409634
3ECM-receptor interaction_Homo sapiens_hsa045122.09678261
4Linoleic acid metabolism_Homo sapiens_hsa005912.09035086
5Pertussis_Homo sapiens_hsa051332.06955043
6Caffeine metabolism_Homo sapiens_hsa002322.02791838
7Adherens junction_Homo sapiens_hsa045201.92560962
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88895967
9Arachidonic acid metabolism_Homo sapiens_hsa005901.85007847
10Leukocyte transendothelial migration_Homo sapiens_hsa046701.83021368
11VEGF signaling pathway_Homo sapiens_hsa043701.82777397
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73907061
13Proteoglycans in cancer_Homo sapiens_hsa052051.72328462
14Amoebiasis_Homo sapiens_hsa051461.70592985
15Focal adhesion_Homo sapiens_hsa045101.65776689
16Bladder cancer_Homo sapiens_hsa052191.63912403
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.63148099
18Vibrio cholerae infection_Homo sapiens_hsa051101.60274833
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58118808
20Fructose and mannose metabolism_Homo sapiens_hsa000511.57996418
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55310243
22Toxoplasmosis_Homo sapiens_hsa051451.48309451
23Acute myeloid leukemia_Homo sapiens_hsa052211.48144475
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44822304
25Other glycan degradation_Homo sapiens_hsa005111.44057303
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42233757
27ErbB signaling pathway_Homo sapiens_hsa040121.41890645
28Proteasome_Homo sapiens_hsa030501.39780693
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38211867
30Platelet activation_Homo sapiens_hsa046111.37172360
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36650570
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36045231
33Vitamin B6 metabolism_Homo sapiens_hsa007501.35158671
34Galactose metabolism_Homo sapiens_hsa000521.32074632
35Small cell lung cancer_Homo sapiens_hsa052221.30467662
36mTOR signaling pathway_Homo sapiens_hsa041501.28038654
37Leishmaniasis_Homo sapiens_hsa051401.27758103
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25499196
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21992440
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21146004
41Tight junction_Homo sapiens_hsa045301.21071911
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21058196
43AMPK signaling pathway_Homo sapiens_hsa041521.20672286
44Malaria_Homo sapiens_hsa051441.19628341
45Shigellosis_Homo sapiens_hsa051311.19213796
46Complement and coagulation cascades_Homo sapiens_hsa046101.17545567
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.17181404
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15943788
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.15413916
50Lysosome_Homo sapiens_hsa041421.14884310
51Chronic myeloid leukemia_Homo sapiens_hsa052201.11995234
52Hippo signaling pathway_Homo sapiens_hsa043901.09645127
53Choline metabolism in cancer_Homo sapiens_hsa052311.07698887
54Salmonella infection_Homo sapiens_hsa051321.06201240
55Tuberculosis_Homo sapiens_hsa051521.06102837
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04590474
57Notch signaling pathway_Homo sapiens_hsa043301.02978631
58Histidine metabolism_Homo sapiens_hsa003401.01983582
59GnRH signaling pathway_Homo sapiens_hsa049121.01696752
60Rap1 signaling pathway_Homo sapiens_hsa040151.01457449
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01383895
62N-Glycan biosynthesis_Homo sapiens_hsa005101.00777598
63Dilated cardiomyopathy_Homo sapiens_hsa054140.99052432
64Biosynthesis of amino acids_Homo sapiens_hsa012300.96747055
65Pancreatic cancer_Homo sapiens_hsa052120.96456689
66Fatty acid elongation_Homo sapiens_hsa000620.95081527
67Prostate cancer_Homo sapiens_hsa052150.94883399
68Inositol phosphate metabolism_Homo sapiens_hsa005620.94063219
69Osteoclast differentiation_Homo sapiens_hsa043800.93707103
70Viral myocarditis_Homo sapiens_hsa054160.93640489
71Sphingolipid metabolism_Homo sapiens_hsa006000.92224661
72Basal cell carcinoma_Homo sapiens_hsa052170.92003932
73MicroRNAs in cancer_Homo sapiens_hsa052060.91909699
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90789790
75Dorso-ventral axis formation_Homo sapiens_hsa043200.90439525
76Axon guidance_Homo sapiens_hsa043600.88688698
77Renal cell carcinoma_Homo sapiens_hsa052110.88140862
78Endocytosis_Homo sapiens_hsa041440.87611370
79Glioma_Homo sapiens_hsa052140.87602015
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86374289
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84756099
82Sulfur relay system_Homo sapiens_hsa041220.84694385
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.81532210
84Legionellosis_Homo sapiens_hsa051340.80477287
85Melanoma_Homo sapiens_hsa052180.80151301
86Fat digestion and absorption_Homo sapiens_hsa049750.79661656
87Endometrial cancer_Homo sapiens_hsa052130.79646221
88Thyroid cancer_Homo sapiens_hsa052160.79125373
89Estrogen signaling pathway_Homo sapiens_hsa049150.78198609
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.77901701
91Apoptosis_Homo sapiens_hsa042100.76368387
92Phenylalanine metabolism_Homo sapiens_hsa003600.75510687
93Ovarian steroidogenesis_Homo sapiens_hsa049130.75443635
94Phagosome_Homo sapiens_hsa041450.74463622
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74381088
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.73648320
97Steroid biosynthesis_Homo sapiens_hsa001000.72522992
98Pathways in cancer_Homo sapiens_hsa052000.70066358
99Renin secretion_Homo sapiens_hsa049240.70018762
100Insulin resistance_Homo sapiens_hsa049310.69998060
101Fatty acid biosynthesis_Homo sapiens_hsa000610.69470078
102TGF-beta signaling pathway_Homo sapiens_hsa043500.69152798
103Ether lipid metabolism_Homo sapiens_hsa005650.67829119
104RNA transport_Homo sapiens_hsa030130.67383360
105Ras signaling pathway_Homo sapiens_hsa040140.66929896
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66920590
107Melanogenesis_Homo sapiens_hsa049160.66782516
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66047614
109Non-small cell lung cancer_Homo sapiens_hsa052230.64901401
110Hepatitis C_Homo sapiens_hsa051600.64183290
111Colorectal cancer_Homo sapiens_hsa052100.64009003
112p53 signaling pathway_Homo sapiens_hsa041150.61904930
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.61296240
114Gastric acid secretion_Homo sapiens_hsa049710.61072561
115Chemokine signaling pathway_Homo sapiens_hsa040620.60802480
116Glucagon signaling pathway_Homo sapiens_hsa049220.59853016
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59084148
118TNF signaling pathway_Homo sapiens_hsa046680.58355161
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57808279
120Pancreatic secretion_Homo sapiens_hsa049720.57307166
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57282304
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.57215235
123B cell receptor signaling pathway_Homo sapiens_hsa046620.56867122
124HIF-1 signaling pathway_Homo sapiens_hsa040660.56523650
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56422954
126Antigen processing and presentation_Homo sapiens_hsa046120.56346857
127Cell cycle_Homo sapiens_hsa041100.55092970
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.54496864
129Carbon metabolism_Homo sapiens_hsa012000.54405753
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52851253
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52490288
132Protein digestion and absorption_Homo sapiens_hsa049740.52443025
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52343420
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52293712
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52052678
136Hedgehog signaling pathway_Homo sapiens_hsa043400.51582322
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51324494
138Hematopoietic cell lineage_Homo sapiens_hsa046400.48056741
139FoxO signaling pathway_Homo sapiens_hsa040680.47235118
140Insulin signaling pathway_Homo sapiens_hsa049100.46356252
141Prolactin signaling pathway_Homo sapiens_hsa049170.46132649
142Prion diseases_Homo sapiens_hsa050200.46078953
143ABC transporters_Homo sapiens_hsa020100.45631028
144Hepatitis B_Homo sapiens_hsa051610.45602921
145Glutathione metabolism_Homo sapiens_hsa004800.44438084
146Lysine degradation_Homo sapiens_hsa003100.42967100

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