KRT81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.88878557
2virion attachment to host cell (GO:0019062)9.69641343
3adhesion of symbiont to host cell (GO:0044650)9.69641343
4citrulline biosynthetic process (GO:0019240)8.78572260
5peptide cross-linking (GO:0018149)8.44296053
6hair follicle morphogenesis (GO:0031069)8.41408403
7adhesion of symbiont to host (GO:0044406)8.18914842
8intermediate filament cytoskeleton organization (GO:0045104)6.64041470
9intermediate filament-based process (GO:0045103)6.42831830
10epidermis development (GO:0008544)6.24898283
11cell wall macromolecule catabolic process (GO:0016998)6.08042508
12cell wall macromolecule metabolic process (GO:0044036)6.08042508
13establishment of skin barrier (GO:0061436)5.90179824
14citrulline metabolic process (GO:0000052)5.80897254
15keratinocyte differentiation (GO:0030216)5.71619696
16hair cycle process (GO:0022405)5.43151059
17molting cycle process (GO:0022404)5.43151059
18regulation of water loss via skin (GO:0033561)5.23709916
19polyketide metabolic process (GO:0030638)5.11801910
20doxorubicin metabolic process (GO:0044598)5.11801910
21daunorubicin metabolic process (GO:0044597)5.11801910
22peptidyl-arginine modification (GO:0018195)4.88545035
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.87897171
24hemidesmosome assembly (GO:0031581)4.78888931
25activation of Rac GTPase activity (GO:0032863)4.77679955
26skin morphogenesis (GO:0043589)4.67169728
27positive regulation of keratinocyte differentiation (GO:0045618)4.63954549
28aminoglycoside antibiotic metabolic process (GO:0030647)4.55827439
29epidermal cell differentiation (GO:0009913)4.46387410
30COPI coating of Golgi vesicle (GO:0048205)4.37087869
31Golgi transport vesicle coating (GO:0048200)4.37087869
32hair cycle (GO:0042633)35.0894919
33molting cycle (GO:0042303)35.0894919
34tooth mineralization (GO:0034505)3.87473660
35keratinocyte development (GO:0003334)3.81752026
36cyclooxygenase pathway (GO:0019371)3.80133057
37protein localization to microtubule (GO:0035372)3.71008652
38nucleobase-containing small molecule interconversion (GO:0015949)3.70356532
39focal adhesion assembly (GO:0048041)3.69608913
40cell-substrate adherens junction assembly (GO:0007045)3.69608913
41mitotic nuclear envelope reassembly (GO:0007084)3.66981160
42nuclear envelope reassembly (GO:0031468)3.66981160
43GDP-mannose metabolic process (GO:0019673)3.59294839
44prostanoid biosynthetic process (GO:0046457)3.58243624
45prostaglandin biosynthetic process (GO:0001516)3.58243624
46membrane raft organization (GO:0031579)3.58193132
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56140495
48multicellular organismal water homeostasis (GO:0050891)3.51197470
49protein retention in ER lumen (GO:0006621)3.47106731
50pentose-phosphate shunt (GO:0006098)3.46532323
51regulation of translational fidelity (GO:0006450)3.44221864
52phosphatidylinositol acyl-chain remodeling (GO:0036149)3.43949536
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41787545
54ribosome assembly (GO:0042255)3.40406258
55regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.39524695
56protein autoprocessing (GO:0016540)3.39371151
57regulation of keratinocyte differentiation (GO:0045616)3.36540018
58chronic inflammatory response (GO:0002544)3.36171523
59proteasome assembly (GO:0043248)3.35427195
60cellular copper ion homeostasis (GO:0006878)3.34662921
61mammary gland epithelial cell proliferation (GO:0033598)3.32990578
62negative regulation of keratinocyte proliferation (GO:0010839)3.27162342
63positive regulation of hair follicle development (GO:0051798)3.23221526
64positive regulation of hair cycle (GO:0042635)3.23221526
65cell adhesion mediated by integrin (GO:0033627)3.23089345
66hair follicle development (GO:0001942)3.22926679
67glucose catabolic process (GO:0006007)3.21989066
68regulation of translational termination (GO:0006449)3.16484210
69amyloid precursor protein metabolic process (GO:0042982)3.15867138
70phosphatidylserine acyl-chain remodeling (GO:0036150)3.11549990
71formation of translation preinitiation complex (GO:0001731)3.10623837
72regulation of mitotic spindle organization (GO:0060236)3.10081774
73adherens junction assembly (GO:0034333)3.08785285
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05556902
75negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.04454303
76regulation of hair follicle development (GO:0051797)3.01971928
77positive regulation of Cdc42 GTPase activity (GO:0043089)2.99922817
78NADPH regeneration (GO:0006740)2.99865549
79prostaglandin metabolic process (GO:0006693)2.97993784
80prostanoid metabolic process (GO:0006692)2.97993784
81bone trabecula formation (GO:0060346)2.96356552
82epithelium development (GO:0060429)2.95131709
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.95044794
84regulation of spindle organization (GO:0090224)2.91443710
85negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.90146783
86phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.88377682
87hypotonic response (GO:0006971)2.88178413
88water homeostasis (GO:0030104)2.87596599
89membrane budding (GO:0006900)2.87465150
90nucleotide-sugar biosynthetic process (GO:0009226)2.84514694
91intestinal epithelial cell development (GO:0060576)2.79845392
92positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.75137967
93positive regulation of meiotic cell cycle (GO:0051446)2.74861053
94gap junction assembly (GO:0016264)2.72992039
95pyrimidine nucleoside salvage (GO:0043097)2.72800769
96pyrimidine-containing compound salvage (GO:0008655)2.72800769
97protein localization to endosome (GO:0036010)2.71668294
98protein maturation by protein folding (GO:0022417)2.71183743
99hepatocyte apoptotic process (GO:0097284)2.71164156
100L-serine transport (GO:0015825)2.70747531
101positive regulation of epidermis development (GO:0045684)2.70119089
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68668194
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67467728
104morphogenesis of embryonic epithelium (GO:0016331)2.66859674
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65903580
106regulation of hippo signaling (GO:0035330)2.65580418
107regulation of hair cycle (GO:0042634)2.65131765
1082-deoxyribonucleotide biosynthetic process (GO:0009265)2.64831309
109deoxyribose phosphate biosynthetic process (GO:0046385)2.64831309
110regulation of phospholipase A2 activity (GO:0032429)2.64039193
111deoxyribonucleotide biosynthetic process (GO:0009263)2.63703581
112regulation of epidermal cell differentiation (GO:0045604)2.62838166
113ribosome biogenesis (GO:0042254)2.61293282
114cellular response to vitamin D (GO:0071305)2.58955242
115ectoderm development (GO:0007398)2.58897709
116regulation of transcription from RNA polymerase I promoter (GO:0006356)2.57254752
117branching involved in mammary gland duct morphogenesis (GO:0060444)2.56862444
118retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54605798
119negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.53953232
120regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53508364
121regulation of cellular amino acid metabolic process (GO:0006521)2.52399160
122regulation of epidermis development (GO:0045682)2.52140685
123regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52028272
124pentose metabolic process (GO:0019321)2.51621327
125atrioventricular valve morphogenesis (GO:0003181)2.51280179
126negative regulation of protein localization to plasma membrane (GO:1903077)2.50942166
127fatty acid elongation (GO:0030497)2.45127973
128epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.41285805
129phosphatidylserine metabolic process (GO:0006658)2.34281739
130phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.29140671
131ventricular cardiac muscle cell action potential (GO:0086005)2.26707574
132wound healing, spreading of epidermal cells (GO:0035313)2.26378224
133negative regulation of cell fate specification (GO:0009996)2.21656835
134cell surface receptor signaling pathway involved in heart development (GO:0061311)2.20489577
135positive regulation of epidermal cell differentiation (GO:0045606)2.18858312
136positive regulation of monocyte chemotaxis (GO:0090026)2.18724151
137skin development (GO:0043588)2.17019686
138regulation of mesenchymal cell apoptotic process (GO:2001053)2.15625138
139cranial suture morphogenesis (GO:0060363)2.14174300
140aging (GO:0007568)2.06531469
141lymph vessel development (GO:0001945)2.04159445
142phosphatidylcholine acyl-chain remodeling (GO:0036151)2.03325137
143regulation of ruffle assembly (GO:1900027)2.02246581
144intermediate filament organization (GO:0045109)12.1379458
145keratinization (GO:0031424)11.8462461
146epithelial cell-cell adhesion (GO:0090136)1.98221945
147outflow tract septum morphogenesis (GO:0003148)1.96249997
148negative regulation of epidermis development (GO:0045683)1.95640927
149regulation of cardioblast differentiation (GO:0051890)1.95365839
150myotube differentiation (GO:0014902)1.94303066
151planar cell polarity pathway involved in neural tube closure (GO:0090179)1.93775156
152cytoskeletal anchoring at plasma membrane (GO:0007016)1.93051925
153regulation of heart rate by cardiac conduction (GO:0086091)1.86751970
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.84992847
155regulation of keratinocyte proliferation (GO:0010837)1.84026574
156ephrin receptor signaling pathway (GO:0048013)1.83377549
157non-canonical Wnt signaling pathway (GO:0035567)1.80982631
158cell communication involved in cardiac conduction (GO:0086065)1.77641619
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.77604564
160cell-substrate junction assembly (GO:0007044)1.76778954
161alditol phosphate metabolic process (GO:0052646)1.72711796
162negative regulation of Ras GTPase activity (GO:0034261)1.71209852
163keratinocyte proliferation (GO:0043616)1.67972747
164regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.66917351
165primary alcohol catabolic process (GO:0034310)1.66210278
166establishment of planar polarity (GO:0001736)1.59579397
167establishment of tissue polarity (GO:0007164)1.59579397
168eyelid development in camera-type eye (GO:0061029)1.59475422
169cardiac right ventricle morphogenesis (GO:0003215)1.59330200
170wound healing, spreading of cells (GO:0044319)1.58508068
171very long-chain fatty acid metabolic process (GO:0000038)1.58215220
172coronary vasculature morphogenesis (GO:0060977)1.57686039
173regulation of monocyte chemotaxis (GO:0090025)1.56109999
174regulation of cardioblast proliferation (GO:0003264)1.55190403
175regulation of secondary heart field cardioblast proliferation (GO:0003266)1.55190403
176regulation of transforming growth factor beta2 production (GO:0032909)1.55158052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.40599334
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.09662828
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.62319546
4E2F7_22180533_ChIP-Seq_HELA_Human2.95941474
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68880294
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64750603
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.59313661
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.44719042
9* CTCF_20526341_ChIP-Seq_ESCs_Human2.25500361
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23742920
11BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.15765433
12NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.15468292
13AR_21909140_ChIP-Seq_LNCAP_Human2.00699458
14TP63_17297297_ChIP-ChIP_HaCaT_Human12.4936264
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95052566
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.89468716
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88084886
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86317627
19TAF2_19829295_ChIP-Seq_ESCs_Human1.86067215
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.79494769
21CSB_26484114_Chip-Seq_FIBROBLAST_Human1.78585288
22P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.77438423
23* E2F1_20622854_ChIP-Seq_HELA_Human1.76995633
24NANOG_20526341_ChIP-Seq_ESCs_Human1.74593882
25EGR1_19032775_ChIP-ChIP_M12_Human1.70695795
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68966440
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68824604
28CTCF_27219007_Chip-Seq_Bcells_Human1.68443992
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67623744
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67282331
31ERG_20517297_ChIP-Seq_VCAP_Human1.65117705
32DCP1A_22483619_ChIP-Seq_HELA_Human1.64102984
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62023027
34LXR_22292898_ChIP-Seq_THP-1_Human1.61879434
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60865740
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60309226
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.60178215
38RACK7_27058665_Chip-Seq_MCF-7_Human1.59235595
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.58317520
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56766270
41TP63_22573176_ChIP-Seq_HFKS_Human1.54831876
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51215192
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.49755915
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49210893
45MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.48144249
46* P53_21459846_ChIP-Seq_SAOS-2_Human1.45948835
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45248417
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45200339
49TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44979235
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44814401
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44814401
52* BCL6_27268052_Chip-Seq_Bcells_Human1.44545494
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43092380
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.42404583
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41771606
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41747509
57ATF3_27146783_Chip-Seq_COLON_Human1.39980313
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39972262
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39804704
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39491784
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38617381
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38421098
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37938962
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.37822390
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37493539
66* BCOR_27268052_Chip-Seq_Bcells_Human1.36569074
67PHF8_20622854_ChIP-Seq_HELA_Human1.34626994
68CLOCK_20551151_ChIP-Seq_293T_Human1.33396021
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32246179
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.31158298
71GATA6_25053715_ChIP-Seq_YYC3_Human1.29589551
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28723594
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.28638614
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27575860
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26946830
76XRN2_22483619_ChIP-Seq_HELA_Human1.25265151
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25094612
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24689193
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.22275570
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22085619
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21370010
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21133588
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.21048767
84E2F1_17053090_ChIP-ChIP_MCF-7_Human1.20778513
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.20477415
86* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18737805
87EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18663585
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18592837
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18107098
90CEBPB_22108803_ChIP-Seq_LS180_Human1.17936453
91ELF5_23300383_ChIP-Seq_T47D_Human1.17490879
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16960837
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16742963
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16643212
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16573117
96KDM5A_27292631_Chip-Seq_BREAST_Human1.16247555
97RAC3_21632823_ChIP-Seq_H3396_Human1.16228641
98* P68_20966046_ChIP-Seq_HELA_Human1.14178480
99* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14083587
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13931709
101CHD1_26751641_Chip-Seq_LNCaP_Human1.12292477
102GABP_19822575_ChIP-Seq_HepG2_Human1.12245649
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10543718
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10237461
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10179283
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.09977892
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09729159
108GATA3_24758297_ChIP-Seq_MCF-7_Human1.08873694
109* ELK1_22589737_ChIP-Seq_MCF10A_Human1.08280458
110TP63_23658742_ChIP-Seq_EP156T_Human1.07965477
111TP53_22127205_ChIP-Seq_IMR90_Human1.07129058
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06986990
113SPI1_20517297_ChIP-Seq_HL60_Human1.06601308
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.06377277
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06035533
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.04820660
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.04793313
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04157346
119RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03697730
120GATA4_25053715_ChIP-Seq_YYC3_Human1.03398314
121JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02901996
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01550732
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00866226
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00108903
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98941401
126E2F1_21310950_ChIP-Seq_MCF-7_Human0.98776317
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98677814
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98441097
129* SMC4_20622854_ChIP-Seq_HELA_Human0.97660960
130SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97447114
131GABP_17652178_ChIP-ChIP_JURKAT_Human0.97126458
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96626352
133TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95725658
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94705003
135* ARNT_22903824_ChIP-Seq_MCF-7_Human0.94445253
136* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94417958
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92518206
138GATA6_21074721_ChIP-Seq_CACO-2_Human0.91634143
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91479148
140* SOX2_21211035_ChIP-Seq_LN229_Human0.91140180
141TP53_18474530_ChIP-ChIP_U2OS_Human0.90874912
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.90236476
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89725249
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.89030490
145* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88789651
146GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86377195
147NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85992141
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85989428
149ZNF263_19887448_ChIP-Seq_K562_Human0.84384068
150RXR_22108803_ChIP-Seq_LS180_Human0.83668378
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.81628550
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81574316
153* AHR_22903824_ChIP-Seq_MCF-7_Human0.80815814
154* KLF5_25053715_ChIP-Seq_YYC3_Human0.80109408
155* FOXH1_21741376_ChIP-Seq_ESCs_Human0.79922308
156RNF2_27304074_Chip-Seq_ESCs_Mouse0.79871761
157SOX2_20726797_ChIP-Seq_SW620_Human0.79790797
158ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79383704
159TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78381163
160* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77318588
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.75945020
162AR_21572438_ChIP-Seq_LNCaP_Human0.73530195
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73301955
164CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71711314
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.71629171
166EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.71302645
167HIF1A_21447827_ChIP-Seq_MCF-7_Human0.71254057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.56668363
2MP0002098_abnormal_vibrissa_morphology7.29947352
3MP0000647_abnormal_sebaceous_gland6.45320810
4MP0002796_impaired_skin_barrier5.94902643
5MP0005275_abnormal_skin_tensile5.13872280
6MP0010234_abnormal_vibrissa_follicle5.13645210
7MP0000383_abnormal_hair_follicle4.44140503
8MP0000377_abnormal_hair_follicle4.07648222
9MP0010678_abnormal_skin_adnexa3.93829277
10MP0003705_abnormal_hypodermis_morpholog3.73567061
11MP0005501_abnormal_skin_physiology3.71714285
12MP0000427_abnormal_hair_cycle3.41966122
13MP0002254_reproductive_system_inflammat3.10399991
14MP0003806_abnormal_nucleotide_metabolis3.09022345
15MP0001216_abnormal_epidermal_layer2.66143621
16MP0004381_abnormal_hair_follicle2.49421388
17MP0000367_abnormal_coat/_hair2.41787325
18MP0010771_integument_phenotype2.31581858
19MP0004947_skin_inflammation2.25953103
20MP0002060_abnormal_skin_morphology2.22814952
21MP0003453_abnormal_keratinocyte_physiol2.21600361
22MP0001243_abnormal_dermal_layer2.13407862
23MP0002234_abnormal_pharynx_morphology2.02216147
24MP0004957_abnormal_blastocyst_morpholog1.90273279
25MP0003693_abnormal_embryo_hatching1.77500486
26MP0000467_abnormal_esophagus_morphology1.72734848
27MP0004233_abnormal_muscle_weight1.69181713
28MP0008932_abnormal_embryonic_tissue1.66871184
29MP0004782_abnormal_surfactant_physiolog1.62195443
30MP0009780_abnormal_chondrocyte_physiolo1.61658928
31MP0000858_altered_metastatic_potential1.56947502
32MP0009053_abnormal_anal_canal1.55722490
33MP0009931_abnormal_skin_appearance1.52564502
34MP0000762_abnormal_tongue_morphology1.51406575
35MP0003566_abnormal_cell_adhesion1.45324352
36MP0003091_abnormal_cell_migration1.30424840
37MP0005330_cardiomyopathy1.30081009
38MP0000358_abnormal_cell_content/1.29830897
39MP0003077_abnormal_cell_cycle1.28291362
40MP0005360_urolithiasis1.28243727
41MP0005623_abnormal_meninges_morphology1.27511691
42MP0003941_abnormal_skin_development1.27223057
43MP0005409_darkened_coat_color1.18979184
44MP0001881_abnormal_mammary_gland1.14340748
45MP0000003_abnormal_adipose_tissue1.08494439
46MP0003111_abnormal_nucleus_morphology1.04707727
47MP0001873_stomach_inflammation1.04270587
48MP0001348_abnormal_lacrimal_gland1.00950775
49MP0000750_abnormal_muscle_regeneration0.99123054
50MP0001730_embryonic_growth_arrest0.99005290
51MP0001191_abnormal_skin_condition0.97816269
52MP0003186_abnormal_redox_activity0.97739634
53MP0001727_abnormal_embryo_implantation0.94002394
54MP0004885_abnormal_endolymph0.93841356
55MP0004185_abnormal_adipocyte_glucose0.93636118
56MP0000350_abnormal_cell_proliferation0.91291591
57MP0004264_abnormal_extraembryonic_tissu0.87277934
58MP0003786_premature_aging0.86880338
59MP0008438_abnormal_cutaneous_collagen0.86120461
60MP0002080_prenatal_lethality0.86021736
61MP0005083_abnormal_biliary_tract0.85646485
62MP0002086_abnormal_extraembryonic_tissu0.84972951
63MP0009697_abnormal_copulation0.84429344
64MP0006035_abnormal_mitochondrial_morpho0.83991344
65MP0008875_abnormal_xenobiotic_pharmacok0.83554841
66MP0002095_abnormal_skin_pigmentation0.81980048
67MP0005621_abnormal_cell_physiology0.81250687
68MP0000490_abnormal_crypts_of0.79847271
69MP0003718_maternal_effect0.77099360
70MP0010094_abnormal_chromosome_stability0.74226757
71MP0010030_abnormal_orbit_morphology0.73722179
72MP0001851_eye_inflammation0.73420477
73MP0002332_abnormal_exercise_endurance0.73324202
74MP0005384_cellular_phenotype0.68477046
75MP0008007_abnormal_cellular_replicative0.68353252
76MP0003315_abnormal_perineum_morphology0.67465721
77MP0001697_abnormal_embryo_size0.67344346
78MP0001340_abnormal_eyelid_morphology0.67050352
79MP0002084_abnormal_developmental_patter0.65611995
80MP0005380_embryogenesis_phenotype0.64522062
81MP0001672_abnormal_embryogenesis/_devel0.64522062
82MP0001849_ear_inflammation0.64098538
83MP0006138_congestive_heart_failure0.64018403
84MP0002877_abnormal_melanocyte_morpholog0.62646143
85MP0001346_abnormal_lacrimal_gland0.61492375
86MP0003984_embryonic_growth_retardation0.61416355
87MP0003191_abnormal_cellular_cholesterol0.59728483
88MP0000566_synostosis0.58186825
89MP0000627_abnormal_mammary_gland0.56694437
90MP0002282_abnormal_trachea_morphology0.56053054
91MP0001661_extended_life_span0.53650713
92MP0003755_abnormal_palate_morphology0.51819431
93MP0005023_abnormal_wound_healing0.49260142
94MP0002970_abnormal_white_adipose0.47560315
95MP0005451_abnormal_body_composition0.47448194
96MP0002249_abnormal_larynx_morphology0.45934854
97MP0001784_abnormal_fluid_regulation0.45756038
98MP0002111_abnormal_tail_morphology0.44120115
99MP0009379_abnormal_foot_pigmentation0.40156408
100MP0005075_abnormal_melanosome_morpholog0.38045312
101MP0010352_gastrointestinal_tract_polyps0.37695614
102MP0003385_abnormal_body_wall0.33541484
103MP0000678_abnormal_parathyroid_gland0.33020923
104MP0004272_abnormal_basement_membrane0.31420311
105MP0002177_abnormal_outer_ear0.31407054
106MP0009840_abnormal_foam_cell0.30845617
107MP0000537_abnormal_urethra_morphology0.27696057
108MP0003763_abnormal_thymus_physiology0.25067556
109MP0003329_amyloid_beta_deposits0.24590076
110MP0002697_abnormal_eye_size0.24572546
111MP0005248_abnormal_Harderian_gland0.23518642
112MP0003950_abnormal_plasma_membrane0.22977967
113MP0000465_gastrointestinal_hemorrhage0.22195345
114MP0004019_abnormal_vitamin_homeostasis0.20216634
115MP0000432_abnormal_head_morphology0.19832001
116MP0006054_spinal_hemorrhage0.18216507
117MP0003935_abnormal_craniofacial_develop0.17904487
118MP0003638_abnormal_response/metabolism_0.17533067
119MP0003448_altered_tumor_morphology0.15931810
120MP0005666_abnormal_adipose_tissue0.15669247
121MP0005076_abnormal_cell_differentiation0.15482965
122MP0003300_gastrointestinal_ulcer0.14368322
123MP0003045_fibrosis0.13484876
124MP0005375_adipose_tissue_phenotype0.13372284
125MP0004858_abnormal_nervous_system0.12905761
126MP0001879_abnormal_lymphatic_vessel0.12866469
127MP0003075_altered_response_to0.12445178
128MP0001958_emphysema0.12139859
129MP0004742_abnormal_vestibular_system0.12082812
130MP0000604_amyloidosis0.12066808
131MP0002006_tumorigenesis0.11892574
132MP0002166_altered_tumor_susceptibility0.11557599
133MP0000516_abnormal_urinary_system0.11252567
134MP0005367_renal/urinary_system_phenotyp0.11252567
135MP0000462_abnormal_digestive_system0.10661103
136MP0000751_myopathy0.09705992
137MP0002233_abnormal_nose_morphology0.08630062
138MP0005508_abnormal_skeleton_morphology0.08115998
139MP0005193_abnormal_anterior_eye0.07893971
140MP0003011_delayed_dark_adaptation0.07488722
141MP0000733_abnormal_muscle_development0.07032618
142MP0005165_increased_susceptibility_to0.05455890
143MP0000013_abnormal_adipose_tissue0.05414022
144MP0008569_lethality_at_weaning0.05368817

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.34003918
2* Brittle hair (HP:0002299)8.64568100
3* Nail dystrophy (HP:0008404)6.76230850
4Abnormality of nail color (HP:0100643)6.35640147
5Abnormal hair laboratory examination (HP:0003328)5.89179508
6Fragile nails (HP:0001808)5.87631332
7Alopecia of scalp (HP:0002293)5.33268446
8Palmoplantar hyperkeratosis (HP:0000972)5.09399223
9Onycholysis (HP:0001806)4.88138780
10Palmar hyperkeratosis (HP:0010765)4.79051098
11* Fine hair (HP:0002213)4.76923968
12Increased IgE level (HP:0003212)4.67036234
13Plantar hyperkeratosis (HP:0007556)4.63412416
14Thick nail (HP:0001805)4.61582745
15Follicular hyperkeratosis (HP:0007502)4.35931507
16Right ventricular cardiomyopathy (HP:0011663)4.33068145
17Trismus (HP:0000211)4.00492607
18Sparse eyelashes (HP:0000653)3.65647873
19Erythema (HP:0010783)3.64146247
20Oral leukoplakia (HP:0002745)3.42687162
21Milia (HP:0001056)3.40320636
22Hypokinesia (HP:0002375)3.36697875
23Amelogenesis imperfecta (HP:0000705)3.35354584
24Distal lower limb amyotrophy (HP:0008944)3.32656668
25Short nail (HP:0001799)3.31792940
26Abnormality of the frontal sinuses (HP:0002687)3.29298190
27Erythroderma (HP:0001019)3.13404928
28Parakeratosis (HP:0001036)3.09935060
29Hypoplasia of dental enamel (HP:0006297)3.06337055
30Pterygium (HP:0001059)3.04564147
31Broad face (HP:0000283)2.95187072
32Flat acetabular roof (HP:0003180)2.94491425
33Reduced subcutaneous adipose tissue (HP:0003758)2.87184824
34Curly hair (HP:0002212)2.86047735
35Congenital ichthyosiform erythroderma (HP:0007431)2.83548359
36Abnormality of the distal phalanges of the toes (HP:0010182)2.79466860
37Poikiloderma (HP:0001029)2.78583105
38Ridged nail (HP:0001807)2.78466525
39Popliteal pterygium (HP:0009756)2.78232324
40Intention tremor (HP:0002080)2.74713727
41Cervical subluxation (HP:0003308)2.74232803
42Fragile skin (HP:0001030)2.70954122
43Vascular calcification (HP:0004934)2.69628112
44Congenital, generalized hypertrichosis (HP:0004540)2.65457369
45Neck muscle weakness (HP:0000467)2.63193035
46Aplasia cutis congenita (HP:0001057)2.61624818
47Spinal cord compression (HP:0002176)2.60789886
48Ankyloglossia (HP:0010296)2.58510991
49Dry hair (HP:0011359)2.55821073
50Abnormal blistering of the skin (HP:0008066)2.53039347
51Hyperacusis (HP:0010780)2.51484618
52Abnormality of oral frenula (HP:0000190)2.50309134
53Torticollis (HP:0000473)2.49277773
54Natal tooth (HP:0000695)2.47994715
55Hypoplasia of the uterus (HP:0000013)2.45640904
56Deviation of the thumb (HP:0009603)2.39290924
57Advanced eruption of teeth (HP:0006288)2.37050143
58Entropion (HP:0000621)2.33800456
59Corneal erosion (HP:0200020)2.29811782
60Lower limb amyotrophy (HP:0007210)2.27190154
61Hypohidrosis (HP:0000966)2.23552471
62Cardiovascular calcification (HP:0011915)2.22596269
63Vertebral compression fractures (HP:0002953)2.19124720
64Cheilitis (HP:0100825)2.17935413
65Rough bone trabeculation (HP:0100670)2.15889566
66Palmoplantar keratoderma (HP:0000982)2.15721854
67Concave nail (HP:0001598)2.14536359
68Craniofacial dystonia (HP:0012179)2.10940672
69Micronodular cirrhosis (HP:0001413)2.10601051
70Abnormality of the salivary glands (HP:0010286)2.09604457
71Ventricular tachycardia (HP:0004756)2.06934750
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.06885703
73Osteolytic defects of the hand bones (HP:0009699)2.06885703
74Abnormality of the pupil (HP:0000615)2.00642192
75Pruritus (HP:0000989)2.00339298
76* Hypotrichosis (HP:0001006)13.8674214
77Woolly hair (HP:0002224)11.6835581
78* Slow-growing hair (HP:0002217)10.1402250
79* Abnormality of hair growth rate (HP:0011363)10.1402250
80Difficulty walking (HP:0002355)1.96836365
81Proximal placement of thumb (HP:0009623)1.95064513
82Difficulty climbing stairs (HP:0003551)1.94012037
83Abnormality of the parietal bone (HP:0002696)1.93115101
84Focal dystonia (HP:0004373)1.92764768
85Flattened epiphyses (HP:0003071)1.90908115
86Glossoptosis (HP:0000162)1.89254975
87Interstitial pulmonary disease (HP:0006530)1.88427305
88Focal segmental glomerulosclerosis (HP:0000097)1.86763793
89Abnormality of dental color (HP:0011073)1.84746322
90Abnormality of the dental root (HP:0006486)1.84069142
91Taurodontia (HP:0000679)1.84069142
92Abnormality of permanent molar morphology (HP:0011071)1.84069142
93Aplasia/hypoplasia of the uterus (HP:0008684)1.82855827
94Abnormality of molar morphology (HP:0011070)1.82439029
95Abnormality of molar (HP:0011077)1.82439029
96Widely patent fontanelles and sutures (HP:0004492)1.80883459
97Hyperactive renin-angiotensin system (HP:0000841)1.80849499
98Ventricular fibrillation (HP:0001663)1.80786181
99Glomerulosclerosis (HP:0000096)1.80189627
100Progressive muscle weakness (HP:0003323)1.78933115
101Vertebral clefting (HP:0008428)1.77291853
102Vertebral hypoplasia (HP:0008417)1.77082377
103Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77082377
104Glucose intolerance (HP:0000833)1.75804015
105Abnormality of the neuromuscular junction (HP:0003398)1.75594256
106Fatigable weakness (HP:0003473)1.75594256
107Abdominal distention (HP:0003270)1.75524578
108Upper limb amyotrophy (HP:0009129)1.75269638
109Distal upper limb amyotrophy (HP:0007149)1.75269638
110Neoplasm of head and neck (HP:0012288)1.74870584
111Esophageal neoplasm (HP:0100751)1.74870584
112Conjunctival hamartoma (HP:0100780)1.73939857
113Absent eyelashes (HP:0000561)1.73248303
114Hyporeflexia of lower limbs (HP:0002600)1.73099181
115Death in infancy (HP:0001522)1.72673774
11611 pairs of ribs (HP:0000878)1.71296396
117Abnormality of the aortic arch (HP:0012303)1.70800313
118Palpitations (HP:0001962)1.69031798
119Nasolacrimal duct obstruction (HP:0000579)1.68189709
120Recurrent corneal erosions (HP:0000495)1.66683630
121Ragged-red muscle fibers (HP:0003200)1.64535547
122Abnormal trabecular bone morphology (HP:0100671)1.64422155
123Tongue fasciculations (HP:0001308)1.64174840
124Blepharitis (HP:0000498)1.63343228
125Abnormality of the dental pulp (HP:0006479)1.60533668
126Unilateral renal agenesis (HP:0000122)1.59974067
127Premature rupture of membranes (HP:0001788)1.59821316
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.59244361
129Fasciculations (HP:0002380)1.59234731
130Amniotic constriction ring (HP:0009775)1.58939228
131Abnormality of placental membranes (HP:0011409)1.58939228
132Dehydration (HP:0001944)1.58102266
133Acanthosis nigricans (HP:0000956)1.57319923
134Absent epiphyses (HP:0010577)1.56783798
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56783798
136Sudden death (HP:0001699)1.56008347
137Lip pit (HP:0100267)1.50581891
138Distal lower limb muscle weakness (HP:0009053)1.48239068
139Achilles tendon contracture (HP:0001771)1.47548534
140Keratoconjunctivitis sicca (HP:0001097)1.47204073
141Gangrene (HP:0100758)1.47199085
142Carious teeth (HP:0000670)1.44598752
143Ectropion (HP:0000656)1.44249975
144Hypergammaglobulinemia (HP:0010702)1.40757833
145Round ear (HP:0100830)1.39684845
146Abnormality of the Achilles tendon (HP:0005109)1.38700922
147Craniofacial hyperostosis (HP:0004493)1.38165937
148Anonychia (HP:0001798)1.36723242
149Selective tooth agenesis (HP:0001592)1.34704657
150Atrophic scars (HP:0001075)1.34296612
151Abnormality of the fingernails (HP:0001231)1.33858444
152Autoamputation (HP:0001218)1.33473957
153Neonatal onset (HP:0003623)1.31323963
154Increased connective tissue (HP:0009025)1.30404064
155Keratoconjunctivitis (HP:0001096)1.30012487
156Lack of skin elasticity (HP:0100679)1.29693266
157Type 1 muscle fiber predominance (HP:0003803)1.27636621
158Sparse scalp hair (HP:0002209)1.25019101
159Widely spaced teeth (HP:0000687)1.20725395
160Bronchomalacia (HP:0002780)1.19890974
161Laryngomalacia (HP:0001601)1.19545123
162Abnormality of the gastric mucosa (HP:0004295)1.17334967
163Wide cranial sutures (HP:0010537)1.15851265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.32381059
2LMTK24.10180506
3MAPKAPK34.05303145
4MAP3K63.98913811
5FER3.83459255
6ERN13.72373964
7NME23.60980262
8TAOK13.10613225
9EPHB23.03308894
10MAP3K32.84041680
11TRIB32.70024281
12BUB12.50577205
13MAP3K112.48445706
14FLT32.44804745
15MAP3K122.37555094
16LATS12.29398198
17MAP3K22.23496025
18NTRK12.23225409
19ARAF2.10718040
20IRAK32.09887549
21RPS6KB21.99241086
22TTN1.75201882
23LATS21.71259503
24MAP2K61.69922337
25EEF2K1.67636057
26PIK3CG1.66402533
27EPHB11.58560500
28EIF2AK11.57895248
29SMG11.46467238
30BMX1.41649939
31NME11.28701065
32MAP2K31.24799046
33BLK1.23416740
34MAP3K11.22850392
35CDK61.22130143
36RIPK11.21338024
37PDGFRA1.20977189
38FGFR21.19713572
39FGFR11.19672484
40DDR21.19637975
41BCR1.14900964
42FGFR41.13607056
43KSR21.10847317
44PKN21.10195235
45MAPKAPK21.06787962
46MST1R1.04466729
47ABL21.01434982
48PIM21.01177734
49SCYL21.00015382
50SIK30.99077464
51LRRK20.97205123
52MAP3K70.93365653
53TESK20.92851407
54PTK60.92726126
55DYRK1B0.89457372
56FGFR30.88257161
57BRSK10.88016194
58MAP3K90.87926855
59SIK10.87891443
60STK100.87360826
61ICK0.83796802
62TYRO30.82706164
63PBK0.80844992
64PTK20.80132351
65CDK120.79674507
66STK380.78501736
67MAP2K10.73739630
68RPS6KA40.72769130
69PAK40.71494731
70MAP2K40.71002521
71TRPM70.70624812
72PRKD10.70347488
73STK38L0.68944067
74TTK0.68278875
75AURKA0.68142759
76MAP3K100.64343478
77TESK10.60971875
78PAK30.60657220
79MYLK0.60381189
80MET0.59170179
81PRKCI0.58304321
82CAMK2G0.57953776
83AURKB0.57741011
84CDK190.56585148
85KSR10.56480218
86BRAF0.55149883
87PRKCH0.54726140
88VRK20.54487991
89NTRK20.53969049
90MOS0.52378397
91GSK3A0.52055022
92MAP3K50.52015352
93MATK0.51725322
94ERBB40.50421936
95RPS6KA10.50367112
96DAPK10.49780214
97MAP3K130.49210588
98PAK60.47452068
99ALK0.46924479
100PAK20.46568239
101RAF10.44930559
102CDK80.44882667
103PTK2B0.44361092
104TGFBR10.44118580
105TSSK60.42288906
106ERBB30.41971252
107RET0.41826473
108ERBB20.41729344
109PDGFRB0.41717530
110FGR0.41680635
111SRPK10.41557857
112CAMK2B0.41122008
113MUSK0.40842294
114NEK10.40119194
115MELK0.39408325
116MAPK120.39157285
117JAK10.38955585
118MST40.38592085
119MAP2K20.38198089
120EPHA30.37566943
121OBSCN0.37512587
122CSNK1E0.37267271
123PHKG20.36863029
124PHKG10.36863029
125JAK20.34801954
126CDC42BPA0.34149399
127ILK0.33477729
128CAMK2D0.33011823
129ZAP700.33005888
130STK240.32423632
131EIF2AK20.31426251
132TAOK20.31411072
133TYK20.31136645
134GRK60.30956432
135CSK0.29987374
136CDK70.28175727
137IRAK20.28007723
138MAP3K80.27841537
139PAK10.27510379
140TGFBR20.26030032
141FYN0.25689613
142LIMK10.25637978
143PLK10.25039139
144JAK30.24332095
145MTOR0.24135362
146SRC0.23178873
147UHMK10.22587864
148CLK10.22346286
149MAPK110.19141939
150PRKG20.18120453
151PRPF4B0.17795098
152CDK90.17677390

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.01021949
2Linoleic acid metabolism_Homo sapiens_hsa005914.97666075
3Proteasome_Homo sapiens_hsa030503.98227085
4Fat digestion and absorption_Homo sapiens_hsa049753.26343977
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.93303251
6Fatty acid elongation_Homo sapiens_hsa000622.73812494
7Galactose metabolism_Homo sapiens_hsa000522.66021651
8Ether lipid metabolism_Homo sapiens_hsa005652.60162141
9Basal cell carcinoma_Homo sapiens_hsa052172.29248714
10Pentose phosphate pathway_Homo sapiens_hsa000302.23862041
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14867223
12Fructose and mannose metabolism_Homo sapiens_hsa000512.07816501
13Arachidonic acid metabolism_Homo sapiens_hsa005901.94689372
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92578415
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86423572
16Sulfur relay system_Homo sapiens_hsa041221.85295544
17Mismatch repair_Homo sapiens_hsa034301.84912113
18Phenylalanine metabolism_Homo sapiens_hsa003601.80914972
19VEGF signaling pathway_Homo sapiens_hsa043701.79568575
20DNA replication_Homo sapiens_hsa030301.77861351
21Pyrimidine metabolism_Homo sapiens_hsa002401.77803107
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.74465160
23Sulfur metabolism_Homo sapiens_hsa009201.73569152
24Small cell lung cancer_Homo sapiens_hsa052221.73144657
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70672388
26Melanogenesis_Homo sapiens_hsa049161.58191035
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54686863
28Nucleotide excision repair_Homo sapiens_hsa034201.54523162
29Hedgehog signaling pathway_Homo sapiens_hsa043401.54174322
30Axon guidance_Homo sapiens_hsa043601.49932333
31Base excision repair_Homo sapiens_hsa034101.47907409
32Bladder cancer_Homo sapiens_hsa052191.46758509
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44975364
34Glutathione metabolism_Homo sapiens_hsa004801.44416368
35N-Glycan biosynthesis_Homo sapiens_hsa005101.44039357
36Vibrio cholerae infection_Homo sapiens_hsa051101.44029755
37Vitamin B6 metabolism_Homo sapiens_hsa007501.43569201
38Histidine metabolism_Homo sapiens_hsa003401.37271283
39Hippo signaling pathway_Homo sapiens_hsa043901.36355265
40Shigellosis_Homo sapiens_hsa051311.35029482
41Biosynthesis of amino acids_Homo sapiens_hsa012301.31084003
42Proteoglycans in cancer_Homo sapiens_hsa052051.30770102
43Glioma_Homo sapiens_hsa052141.30557321
44Thyroid cancer_Homo sapiens_hsa052161.28758096
45Carbon metabolism_Homo sapiens_hsa012001.28362873
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.28244981
47GnRH signaling pathway_Homo sapiens_hsa049121.25689142
48Ribosome_Homo sapiens_hsa030101.22816890
49Caffeine metabolism_Homo sapiens_hsa002321.22559383
50Acute myeloid leukemia_Homo sapiens_hsa052211.18589336
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15450567
52Tight junction_Homo sapiens_hsa045301.15404102
53Cell cycle_Homo sapiens_hsa041101.13227557
54Folate biosynthesis_Homo sapiens_hsa007901.11328332
55Pancreatic secretion_Homo sapiens_hsa049721.08915806
56Dorso-ventral axis formation_Homo sapiens_hsa043201.07419181
57Pyruvate metabolism_Homo sapiens_hsa006201.06926185
58Adherens junction_Homo sapiens_hsa045201.04211724
59Mineral absorption_Homo sapiens_hsa049781.02291235
60One carbon pool by folate_Homo sapiens_hsa006700.99907380
61PPAR signaling pathway_Homo sapiens_hsa033200.98240474
62Long-term potentiation_Homo sapiens_hsa047200.98237767
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97580238
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97071298
65ECM-receptor interaction_Homo sapiens_hsa045120.95674935
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.95554088
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94715574
68Homologous recombination_Homo sapiens_hsa034400.94671428
69Nitrogen metabolism_Homo sapiens_hsa009100.91881270
70RNA transport_Homo sapiens_hsa030130.90943289
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90673973
72Pancreatic cancer_Homo sapiens_hsa052120.90512207
73Steroid biosynthesis_Homo sapiens_hsa001000.88939451
74RNA polymerase_Homo sapiens_hsa030200.87983289
75Tyrosine metabolism_Homo sapiens_hsa003500.86059612
76Endometrial cancer_Homo sapiens_hsa052130.85889333
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85433431
78Estrogen signaling pathway_Homo sapiens_hsa049150.84747065
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84273251
80Wnt signaling pathway_Homo sapiens_hsa043100.83983252
81Ras signaling pathway_Homo sapiens_hsa040140.83189563
82Non-small cell lung cancer_Homo sapiens_hsa052230.83186663
83Pertussis_Homo sapiens_hsa051330.82118841
84Long-term depression_Homo sapiens_hsa047300.81944918
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80650816
86Spliceosome_Homo sapiens_hsa030400.79952438
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78836985
88beta-Alanine metabolism_Homo sapiens_hsa004100.78678794
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.76760524
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.76530949
91Staphylococcus aureus infection_Homo sapiens_hsa051500.76114466
92Amoebiasis_Homo sapiens_hsa051460.74944535
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.73722926
94Fatty acid metabolism_Homo sapiens_hsa012120.70805621
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69282095
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69204302
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68600912
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68568681
99Fatty acid biosynthesis_Homo sapiens_hsa000610.66503498
100Apoptosis_Homo sapiens_hsa042100.66374280
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.65788747
102MicroRNAs in cancer_Homo sapiens_hsa052060.65208046
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.64088839
104Gastric acid secretion_Homo sapiens_hsa049710.62625265
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62005920
106Renin secretion_Homo sapiens_hsa049240.61636200
107Endocytosis_Homo sapiens_hsa041440.61168537
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60515297
109Gap junction_Homo sapiens_hsa045400.60183721
110Phototransduction_Homo sapiens_hsa047440.58962272
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58607548
112Rap1 signaling pathway_Homo sapiens_hsa040150.55863709
113Salmonella infection_Homo sapiens_hsa051320.54714347
114Insulin resistance_Homo sapiens_hsa049310.53832199
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.53524282
116Hepatitis C_Homo sapiens_hsa051600.53335059
117Sphingolipid metabolism_Homo sapiens_hsa006000.52269373
118Protein digestion and absorption_Homo sapiens_hsa049740.52205808
119Focal adhesion_Homo sapiens_hsa045100.52040397
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51737928
121TGF-beta signaling pathway_Homo sapiens_hsa043500.50298579
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.49565007
123ErbB signaling pathway_Homo sapiens_hsa040120.49451209
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48248668
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47864462
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47813088
127Salivary secretion_Homo sapiens_hsa049700.47765378
128Other glycan degradation_Homo sapiens_hsa005110.47669726
129Purine metabolism_Homo sapiens_hsa002300.47063608
130Platelet activation_Homo sapiens_hsa046110.46303072
131Notch signaling pathway_Homo sapiens_hsa043300.46223920
132Oxytocin signaling pathway_Homo sapiens_hsa049210.45703709
133p53 signaling pathway_Homo sapiens_hsa041150.45346186
134Renal cell carcinoma_Homo sapiens_hsa052110.44699623
135Alzheimers disease_Homo sapiens_hsa050100.44378894
136Metabolic pathways_Homo sapiens_hsa011000.44189272
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44044208
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43884217
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43283621
140Butanoate metabolism_Homo sapiens_hsa006500.42894960
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42644892
142Chronic myeloid leukemia_Homo sapiens_hsa052200.42235543
143Fatty acid degradation_Homo sapiens_hsa000710.41381404
144Huntingtons disease_Homo sapiens_hsa050160.40685412
145Dilated cardiomyopathy_Homo sapiens_hsa054140.40527041
146Arginine and proline metabolism_Homo sapiens_hsa003300.40387671
147Prion diseases_Homo sapiens_hsa050200.39755902
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39444734
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38021890
150Arginine biosynthesis_Homo sapiens_hsa002200.37562856
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37560958
152Pathways in cancer_Homo sapiens_hsa052000.37415678
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37105828
154Chemical carcinogenesis_Homo sapiens_hsa052040.36967675
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36252695
156Tuberculosis_Homo sapiens_hsa051520.36151742
157Insulin signaling pathway_Homo sapiens_hsa049100.35792704
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34998412
159Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34997487
160Olfactory transduction_Homo sapiens_hsa047400.34453861
161Prolactin signaling pathway_Homo sapiens_hsa049170.34452721
162Starch and sucrose metabolism_Homo sapiens_hsa005000.33304181
163Viral carcinogenesis_Homo sapiens_hsa052030.32003884

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