KRT82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.39546760
2adhesion of symbiont to host cell (GO:0044650)9.39546760
3peptide cross-linking (GO:0018149)8.28816437
4citrulline biosynthetic process (GO:0019240)8.11649541
5adhesion of symbiont to host (GO:0044406)7.89074834
6hair follicle morphogenesis (GO:0031069)7.82120713
7establishment of skin barrier (GO:0061436)7.22387260
8cell wall macromolecule catabolic process (GO:0016998)7.19944641
9cell wall macromolecule metabolic process (GO:0044036)7.19944641
10regulation of water loss via skin (GO:0033561)6.43350586
11keratinocyte differentiation (GO:0030216)6.30391783
12intermediate filament cytoskeleton organization (GO:0045104)6.30374391
13epidermis development (GO:0008544)6.20552321
14intermediate filament-based process (GO:0045103)6.09097166
15skin morphogenesis (GO:0043589)5.71460020
16molting cycle process (GO:0022404)5.37634082
17hair cycle process (GO:0022405)5.37634082
18citrulline metabolic process (GO:0000052)5.31996224
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.25377799
20hemidesmosome assembly (GO:0031581)5.03346675
21epidermal cell differentiation (GO:0009913)5.00228017
22keratinocyte development (GO:0003334)4.56250960
23peptidyl-arginine modification (GO:0018195)4.37300601
24multicellular organismal water homeostasis (GO:0050891)4.26580133
25tooth mineralization (GO:0034505)4.22245564
26hair cycle (GO:0042633)31.1747516
27molting cycle (GO:0042303)31.1747516
28hair follicle development (GO:0001942)3.55531371
29ectoderm development (GO:0007398)3.54428348
30negative regulation of keratinocyte proliferation (GO:0010839)3.46846730
31water homeostasis (GO:0030104)3.46198321
32positive regulation of hair cycle (GO:0042635)3.44020935
33positive regulation of hair follicle development (GO:0051798)3.44020935
34bone trabecula formation (GO:0060346)3.31942819
35regulation of hair follicle development (GO:0051797)3.27261339
36regulation of keratinocyte differentiation (GO:0045616)3.20675934
37fatty acid elongation (GO:0030497)3.06171476
38regulation of hair cycle (GO:0042634)3.02399452
39epithelium development (GO:0060429)2.96880197
40negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.91492933
41positive regulation of meiotic cell cycle (GO:0051446)2.83597856
42positive regulation of epidermis development (GO:0045684)2.83513205
43phosphatidylinositol acyl-chain remodeling (GO:0036149)2.82730347
44regulation of mesenchymal cell apoptotic process (GO:2001053)2.81596708
45atrioventricular valve morphogenesis (GO:0003181)2.80234861
46wound healing, spreading of epidermal cells (GO:0035313)2.65377288
47phosphatidylserine acyl-chain remodeling (GO:0036150)2.64346324
48epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60243636
49gap junction assembly (GO:0016264)2.59028220
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58197306
51negative regulation of cell fate specification (GO:0009996)2.57596434
52cell surface receptor signaling pathway involved in heart development (GO:0061311)2.53079595
53cranial suture morphogenesis (GO:0060363)2.50528331
54regulation of epidermis development (GO:0045682)2.49384776
55keratinocyte proliferation (GO:0043616)2.46730042
56regulation of epidermal cell differentiation (GO:0045604)2.45196818
57skin development (GO:0043588)2.42126260
58negative regulation of protein localization to plasma membrane (GO:1903077)2.39835914
59lymph vessel development (GO:0001945)2.39650222
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36162156
61ventricular cardiac muscle cell action potential (GO:0086005)2.35938919
62phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.34658983
63positive regulation of epidermal cell differentiation (GO:0045606)2.32235550
64glial cell proliferation (GO:0014009)2.31606429
65positive regulation of monocyte chemotaxis (GO:0090026)2.29963419
66epithelial cell-cell adhesion (GO:0090136)2.24450230
67negative regulation of epidermis development (GO:0045683)2.20434571
68outflow tract septum morphogenesis (GO:0003148)2.19533833
69myotube differentiation (GO:0014902)2.17308192
70regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.15678025
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.13657008
72branching involved in mammary gland duct morphogenesis (GO:0060444)2.12977891
73regulation of cardioblast differentiation (GO:0051890)2.09565104
74eyelid development in camera-type eye (GO:0061029)2.07444482
75non-canonical Wnt signaling pathway (GO:0035567)2.07279433
76negative regulation of cardiac muscle hypertrophy (GO:0010614)2.05925299
77response to UV-B (GO:0010224)2.05920171
78lateral sprouting from an epithelium (GO:0060601)2.05915509
79muscle organ morphogenesis (GO:0048644)2.05459640
80negative regulation of muscle hypertrophy (GO:0014741)2.04169707
81regulation of keratinocyte proliferation (GO:0010837)2.03163663
82regulation of heart rate by cardiac conduction (GO:0086091)2.02976112
83regulation of ruffle assembly (GO:1900027)2.01051342
84keratinization (GO:0031424)11.7564329
85intermediate filament organization (GO:0045109)11.3153963
86desmosome organization (GO:0002934)10.9613343
87cytoskeletal anchoring at plasma membrane (GO:0007016)1.96798736
88phosphatidylethanolamine acyl-chain remodeling (GO:0036152)1.95994850
89cardiac right ventricle morphogenesis (GO:0003215)1.94808709
90ephrin receptor signaling pathway (GO:0048013)1.93377383
91phosphatidylserine metabolic process (GO:0006658)1.92976058
92long-chain fatty acid biosynthetic process (GO:0042759)1.91760765
93establishment of tissue polarity (GO:0007164)1.86803060
94establishment of planar polarity (GO:0001736)1.86803060
95wound healing, spreading of cells (GO:0044319)1.86245711
96regulation of cardioblast proliferation (GO:0003264)1.85604616
97regulation of secondary heart field cardioblast proliferation (GO:0003266)1.85604616
98outer ear morphogenesis (GO:0042473)1.85387460
99cell-substrate junction assembly (GO:0007044)1.80028723
100negative regulation of cell fate commitment (GO:0010454)1.79206975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.87483282
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.42456301
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.35945386
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.34701820
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.91987964
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.11470712
7TP63_17297297_ChIP-ChIP_HaCaT_Human12.8215405
8CTCF_20526341_ChIP-Seq_ESCs_Human1.88481150
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.86954539
10SOX9_24532713_ChIP-Seq_HFSC_Mouse1.83962880
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78438428
12NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.71730698
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64897721
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64897721
15EGR1_19032775_ChIP-ChIP_M12_Human1.60904716
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58181802
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.57430724
18E2F1_20622854_ChIP-Seq_HELA_Human1.54332257
19TP53_20018659_ChIP-ChIP_R1E_Mouse1.51019948
20TAF2_19829295_ChIP-Seq_ESCs_Human1.48339419
21CSB_26484114_Chip-Seq_FIBROBLAST_Human1.44614668
22CTCF_27219007_Chip-Seq_Bcells_Human1.43842340
23P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.43598708
24ERG_20517297_ChIP-Seq_VCAP_Human1.40898393
25NANOG_20526341_ChIP-Seq_ESCs_Human1.40775369
26RACK7_27058665_Chip-Seq_MCF-7_Human1.39405153
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.36921952
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33188503
29TP63_22573176_ChIP-Seq_HFKS_Human1.31791315
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.31554257
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30550767
32MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.28414375
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27815037
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26316162
35ZNF263_19887448_ChIP-Seq_K562_Human1.25643184
36AHR_22903824_ChIP-Seq_MCF-7_Human1.24584822
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23992148
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.23500749
39P53_21459846_ChIP-Seq_SAOS-2_Human1.23012881
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.21424240
41ATF3_27146783_Chip-Seq_COLON_Human1.21109001
42RXR_22108803_ChIP-Seq_LS180_Human1.20338225
43BCL6_27268052_Chip-Seq_Bcells_Human1.19057772
44LXR_22292898_ChIP-Seq_THP-1_Human1.18929634
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.17431402
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17205824
47BCOR_27268052_Chip-Seq_Bcells_Human1.13487362
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12851846
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10954288
50GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10774054
51* TP63_23658742_ChIP-Seq_EP156T_Human1.10289097
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09305811
53CEBPB_22108803_ChIP-Seq_LS180_Human1.09066100
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.08646640
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.07290845
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07019453
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05761169
58TP53_18474530_ChIP-ChIP_U2OS_Human1.04958804
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.03370245
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00614785
61GATA4_25053715_ChIP-Seq_YYC3_Human1.00185925
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99250363
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96150373
64KLF5_25053715_ChIP-Seq_YYC3_Human0.96116807
65SA1_27219007_Chip-Seq_ERYTHROID_Human0.94970517
66RAC3_21632823_ChIP-Seq_H3396_Human0.94208029
67P68_20966046_ChIP-Seq_HELA_Human0.93761462
68PHF8_20622854_ChIP-Seq_HELA_Human0.93580369
69P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93399474
70RUNX1_27514584_Chip-Seq_MCF-7_Human0.92503550
71SOX2_20726797_ChIP-Seq_SW620_Human0.92273985
72EZH2_27304074_Chip-Seq_ESCs_Mouse0.91676129
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91133409
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.90170413
75RNF2_27304074_Chip-Seq_ESCs_Mouse0.87582308
76AR_21572438_ChIP-Seq_LNCaP_Human0.87320948
77RING1B_27294783_Chip-Seq_ESCs_Mouse0.87286671
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87150073
79ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86794625
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86339581
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85376827
82TCF4_18268006_ChIP-ChIP_LS174T_Human0.84099698
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83408445
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81901668
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81861741
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.81514127
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81467629
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78339875
89EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76553314
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76553314
91* SMC4_20622854_ChIP-Seq_HELA_Human0.74761839
92* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73727432
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.73442943
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.73389747
95CJUN_26792858_Chip-Seq_BT549_Human0.72673635
96RUNX_20019798_ChIP-Seq_JUKART_Human0.72500763
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72202116
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.71863529
99BCAT_22108803_ChIP-Seq_LS180_Human0.70943732
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.70600162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.45664992
2MP0002098_abnormal_vibrissa_morphology6.58048151
3MP0002796_impaired_skin_barrier6.11889851
4MP0000647_abnormal_sebaceous_gland5.88397497
5MP0005275_abnormal_skin_tensile5.44535416
6MP0000383_abnormal_hair_follicle4.85585258
7MP0010234_abnormal_vibrissa_follicle4.60752357
8MP0010678_abnormal_skin_adnexa4.15439148
9MP0000377_abnormal_hair_follicle3.91588978
10MP0000427_abnormal_hair_cycle3.74391592
11MP0005501_abnormal_skin_physiology3.73811362
12MP0003705_abnormal_hypodermis_morpholog3.31331705
13MP0002254_reproductive_system_inflammat2.92164544
14MP0004381_abnormal_hair_follicle2.84296921
15MP0001216_abnormal_epidermal_layer2.80273068
16MP0004947_skin_inflammation2.68210019
17MP0010771_integument_phenotype2.38301295
18MP0002060_abnormal_skin_morphology2.37098010
19MP0001243_abnormal_dermal_layer2.33092827
20MP0000367_abnormal_coat/_hair2.29408880
21MP0003453_abnormal_keratinocyte_physiol2.13900323
22MP0002234_abnormal_pharynx_morphology1.73604348
23MP0003941_abnormal_skin_development1.70741566
24MP0000467_abnormal_esophagus_morphology1.61947689
25MP0009931_abnormal_skin_appearance1.55079408
26MP0000762_abnormal_tongue_morphology1.51202491
27MP0005409_darkened_coat_color1.31267495
28MP0009053_abnormal_anal_canal1.26987177
29MP0003566_abnormal_cell_adhesion1.25582621
30MP0001661_extended_life_span1.09859088
31MP0001346_abnormal_lacrimal_gland1.09399246
32MP0002009_preneoplasia1.07861217
33MP0001191_abnormal_skin_condition1.06971039
34MP0002095_abnormal_skin_pigmentation1.03114567
35MP0008438_abnormal_cutaneous_collagen0.90541535
36MP0000627_abnormal_mammary_gland0.85524046
37MP0001340_abnormal_eyelid_morphology0.83228472
38MP0004885_abnormal_endolymph0.80910867
39MP0010030_abnormal_orbit_morphology0.80903469
40MP0000566_synostosis0.80789777
41MP0004264_abnormal_extraembryonic_tissu0.78763274
42MP0001851_eye_inflammation0.76953156
43MP0003950_abnormal_plasma_membrane0.75490629
44MP0004185_abnormal_adipocyte_glucose0.69934920
45MP0005451_abnormal_body_composition0.68891045
46MP0003315_abnormal_perineum_morphology0.58124795
47MP0002282_abnormal_trachea_morphology0.56945562
48MP0001849_ear_inflammation0.56510569
49MP0002249_abnormal_larynx_morphology0.55097160
50MP0003755_abnormal_palate_morphology0.54167718
51MP0002877_abnormal_melanocyte_morpholog0.53309546
52MP0002006_tumorigenesis0.50757451
53MP0002166_altered_tumor_susceptibility0.50648004
54MP0002970_abnormal_white_adipose0.48378158
55MP0001784_abnormal_fluid_regulation0.48226582
56MP0002177_abnormal_outer_ear0.45176190
57MP0005075_abnormal_melanosome_morpholog0.44272574
58MP0005248_abnormal_Harderian_gland0.44055804
59MP0000537_abnormal_urethra_morphology0.42074349
60MP0002697_abnormal_eye_size0.40639804
61MP0003191_abnormal_cellular_cholesterol0.39704074
62MP0003385_abnormal_body_wall0.36040747
63MP0005023_abnormal_wound_healing0.34850166
64MP0003763_abnormal_thymus_physiology0.34571645
65MP0002111_abnormal_tail_morphology0.34348764
66MP0006054_spinal_hemorrhage0.32010339
67MP0009379_abnormal_foot_pigmentation0.31658261
68MP0002896_abnormal_bone_mineralization0.30267667
69MP0004272_abnormal_basement_membrane0.29411479
70MP0001348_abnormal_lacrimal_gland0.29264414
71MP0005508_abnormal_skeleton_morphology0.28263703
72MP0000432_abnormal_head_morphology0.28126258
73MP0001188_hyperpigmentation0.25142277
74MP0010352_gastrointestinal_tract_polyps0.24205199
75MP0003936_abnormal_reproductive_system0.22479283
76MP0000678_abnormal_parathyroid_gland0.21390417
77MP0002233_abnormal_nose_morphology0.20252745
78MP0004742_abnormal_vestibular_system0.19593396
79MP0005503_abnormal_tendon_morphology0.19431082
80MP0000516_abnormal_urinary_system0.18248331
81MP0005367_renal/urinary_system_phenotyp0.18248331
82MP0000465_gastrointestinal_hemorrhage0.18098272
83MP0003448_altered_tumor_morphology0.16808874
84MP0003935_abnormal_craniofacial_develop0.15756361
85MP0005076_abnormal_cell_differentiation0.14522507
86MP0000372_irregular_coat_pigmentation0.13717823
87MP0005193_abnormal_anterior_eye0.13342670
88MP0005257_abnormal_intraocular_pressure0.12459955
89MP0004858_abnormal_nervous_system0.11496839
90MP0000751_myopathy0.10952633
91MP0001542_abnormal_bone_strength0.10841390
92MP0000733_abnormal_muscle_development0.10767680
93MP0000613_abnormal_salivary_gland0.10595364
94MP0009840_abnormal_foam_cell0.09996871
95MP0001881_abnormal_mammary_gland0.09447840
96MP0003300_gastrointestinal_ulcer0.09324330
97MP0009384_cardiac_valve_regurgitation0.09144870
98MP0004019_abnormal_vitamin_homeostasis0.08654373
99MP0000747_muscle_weakness0.08602103
100MP0000013_abnormal_adipose_tissue0.08543724

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.61952531
2Slow-growing hair (HP:0002217)9.40856051
3Abnormality of hair growth rate (HP:0011363)9.40856051
4Brittle hair (HP:0002299)8.96232364
5Nail dystrophy (HP:0008404)6.41859004
6Abnormal hair laboratory examination (HP:0003328)6.08222046
7Abnormality of nail color (HP:0100643)5.90313391
8Fragile nails (HP:0001808)5.56932482
9Increased IgE level (HP:0003212)5.11842490
10Palmoplantar hyperkeratosis (HP:0000972)5.11668970
11Follicular hyperkeratosis (HP:0007502)5.07843936
12Onycholysis (HP:0001806)4.96543008
13Alopecia of scalp (HP:0002293)4.88738464
14Palmar hyperkeratosis (HP:0010765)4.85491904
15Plantar hyperkeratosis (HP:0007556)4.66015727
16Thick nail (HP:0001805)4.55362396
17Fine hair (HP:0002213)4.52788749
18Congenital, generalized hypertrichosis (HP:0004540)4.22187499
19Right ventricular cardiomyopathy (HP:0011663)4.17992250
20Sparse eyelashes (HP:0000653)4.10911675
21Erythema (HP:0010783)4.03864023
22Parakeratosis (HP:0001036)3.44950489
23Milia (HP:0001056)3.38749333
24Erythroderma (HP:0001019)3.25508325
25Oral leukoplakia (HP:0002745)3.25291576
26Abnormality of the frontal sinuses (HP:0002687)3.18252783
27Amelogenesis imperfecta (HP:0000705)3.12312403
28Aplasia cutis congenita (HP:0001057)2.87645848
29Ridged nail (HP:0001807)2.78563097
30Natal tooth (HP:0000695)2.72606074
31Curly hair (HP:0002212)2.72580634
32Congenital ichthyosiform erythroderma (HP:0007431)2.71406189
33Advanced eruption of teeth (HP:0006288)2.70254675
34Abnormal blistering of the skin (HP:0008066)2.48717812
35Neck muscle weakness (HP:0000467)2.39232822
36Lip pit (HP:0100267)2.35095083
37Corneal erosion (HP:0200020)2.17612036
38Hypohidrosis (HP:0000966)2.16131805
39Abnormality of the parietal bone (HP:0002696)2.15688729
40Conjunctival hamartoma (HP:0100780)2.14969759
41Concave nail (HP:0001598)2.13745376
42Intention tremor (HP:0002080)2.13079927
43Pruritus (HP:0000989)2.11120132
44Dry hair (HP:0011359)2.10168643
45Palmoplantar keratoderma (HP:0000982)2.04748484
46Torticollis (HP:0000473)2.02265588
47Hypotrichosis (HP:0001006)13.4663517
48Woolly hair (HP:0002224)11.0099416
49Ventricular tachycardia (HP:0004756)1.99144306
50Absent eyelashes (HP:0000561)1.97013717
51Abnormality of permanent molar morphology (HP:0011071)1.91320572
52Abnormality of the dental root (HP:0006486)1.91320572
53Taurodontia (HP:0000679)1.91320572
54Abnormality of molar morphology (HP:0011070)1.88468876
55Abnormality of molar (HP:0011077)1.88468876
56Abnormality of the neuromuscular junction (HP:0003398)1.88244167
57Fatigable weakness (HP:0003473)1.88244167
58Widely patent fontanelles and sutures (HP:0004492)1.75165125
59Abnormality of the aortic arch (HP:0012303)1.72687278
60Difficulty walking (HP:0002355)1.67154533
61Unilateral renal agenesis (HP:0000122)1.66818165
62Type 1 muscle fiber predominance (HP:0003803)1.66414202
63Abnormality of the dental pulp (HP:0006479)1.65742229
64Ventricular fibrillation (HP:0001663)1.65149191
65Gangrene (HP:0100758)1.65026691
66Atrophic scars (HP:0001075)1.64919709
67Abnormality of dental color (HP:0011073)1.64753312
68Premature rupture of membranes (HP:0001788)1.62665960
69Hyporeflexia of lower limbs (HP:0002600)1.62584688
70Craniofacial dystonia (HP:0012179)1.62296500
71Abnormality of the pupil (HP:0000615)1.62165213
72Acanthosis nigricans (HP:0000956)1.61939472
73Recurrent corneal erosions (HP:0000495)1.61931782
74Keratoconjunctivitis sicca (HP:0001097)1.61509188
75Hypergammaglobulinemia (HP:0010702)1.57481432
76Blepharitis (HP:0000498)1.56701079
77Distal lower limb muscle weakness (HP:0009053)1.53373991
78Sparse scalp hair (HP:0002209)1.50529636
79Round ear (HP:0100830)1.48531040
80Increased connective tissue (HP:0009025)1.47160175
81Focal dystonia (HP:0004373)1.46097207
82Amniotic constriction ring (HP:0009775)1.44463458
83Abnormality of placental membranes (HP:0011409)1.44463458
84Keratoconjunctivitis (HP:0001096)1.43077100
85Achilles tendon contracture (HP:0001771)1.42511055
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.40146291
87Craniofacial hyperostosis (HP:0004493)1.39578956
88Carious teeth (HP:0000670)1.35269010
89Autoimmune hemolytic anemia (HP:0001890)1.34910615
90Sudden death (HP:0001699)1.33679481
91Abnormality of the fingernails (HP:0001231)1.33401155
92Ectropion (HP:0000656)1.32191891
93Abnormality of the Achilles tendon (HP:0005109)1.31720816
94Hamartoma of the eye (HP:0010568)1.30573688
95Selective tooth agenesis (HP:0001592)1.29744102
96Absent hair (HP:0002298)1.28264691
97Fragile skin (HP:0001030)1.25972204
98Anonychia (HP:0001798)1.25533440
99Abnormality of the axillary hair (HP:0100134)1.24189977
100Abnormality of secondary sexual hair (HP:0009888)1.24189977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.39882278
2EPHA23.61532393
3MAPKAPK33.43859035
4TAOK13.28356864
5EPHB23.28314956
6MAP3K63.18972881
7MAP3K32.66502069
8ERN12.51868937
9FGFR22.44264725
10CDK32.38675232
11LATS12.29556663
12PIK3CG2.28933853
13BCR2.27114794
14MAP3K112.14616653
15BLK2.08568848
16FGFR11.88545510
17TTN1.87395837
18MAP3K21.70492458
19RPS6KB21.69459405
20TRIB31.67342934
21MAP3K71.54242744
22FGFR31.45711594
23EEF2K1.40242246
24BMX1.38393425
25FGFR41.38037514
26CDK61.36449555
27LATS21.30602026
28OBSCN1.28895122
29MAPKAPK21.26900474
30MST1R1.17246699
31TNK21.17052059
32MAP2K41.05463512
33MAP3K11.04684202
34MAP3K121.04005215
35RPS6KA41.03274169
36MAP2K61.02318079
37DYRK1B0.99937402
38MAP2K30.99195746
39EPHB10.98793136
40MAP3K130.95787901
41TRPM70.93515746
42PIM20.89820728
43PDGFRA0.85556200
44LRRK20.82458776
45PRKD10.82003388
46PTK60.81474332
47MST40.77955578
48TYRO30.74873114
49CSNK1D0.71693126
50PHKG20.68320280
51PHKG10.68320280
52MAP3K100.66895905
53ERBB30.65623869
54PRKCE0.65598524
55NTRK20.65333823
56MAP3K140.64274913
57TYK20.63932430
58PAK40.63622139
59PRKCH0.63596772
60ITK0.62475036
61STK240.60437290
62MAP2K10.58184500
63PRKCG0.56376257
64CLK10.54767690
65PBK0.54726591
66NME10.54385120
67RIPK10.53644102
68ERBB20.53430498
69SIK10.52490635
70KSR20.51338073
71STK38L0.50141241
72GSK3A0.48018271
73TBK10.47500667
74ERBB40.47286460
75RPS6KA10.46807763
76PAK30.46225503
77IKBKE0.43601093
78FYN0.42706633
79TGFBR20.42609074
80PTK20.41754614
81DDR20.41754117
82RET0.40761332
83MARK20.40038981
84PAK20.39238608
85PRKCI0.39148354
86MAP3K50.38064586
87MET0.37205893
88MAP3K80.35935511
89MAPK120.34964278
90MAPK40.33917909
91ILK0.32577630
92PRKCA0.32538047
93CSK0.31199534
94SGK30.30406038
95HCK0.29386815
96TGFBR10.26814700
97STK30.26205957
98MAPK80.25517841
99SGK10.25312303
100PRKD20.25271029

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.80443639
2Linoleic acid metabolism_Homo sapiens_hsa005913.53679306
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.52595385
4Basal cell carcinoma_Homo sapiens_hsa052172.71709687
5Fatty acid elongation_Homo sapiens_hsa000622.57078145
6Antigen processing and presentation_Homo sapiens_hsa046122.35596953
7Fat digestion and absorption_Homo sapiens_hsa049752.05669058
8Hedgehog signaling pathway_Homo sapiens_hsa043401.92987231
9Ether lipid metabolism_Homo sapiens_hsa005651.92303558
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79562141
11Melanogenesis_Homo sapiens_hsa049161.62860638
12Hippo signaling pathway_Homo sapiens_hsa043901.62842022
13Phenylalanine metabolism_Homo sapiens_hsa003601.59562647
14Arachidonic acid metabolism_Homo sapiens_hsa005901.53741259
15Axon guidance_Homo sapiens_hsa043601.47682115
16Adherens junction_Homo sapiens_hsa045201.42187898
17VEGF signaling pathway_Homo sapiens_hsa043701.41097933
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37209775
19Proteoglycans in cancer_Homo sapiens_hsa052051.36734432
20Mineral absorption_Homo sapiens_hsa049781.26922219
21Acute myeloid leukemia_Homo sapiens_hsa052211.23059581
22Staphylococcus aureus infection_Homo sapiens_hsa051501.22254881
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21561306
24Histidine metabolism_Homo sapiens_hsa003401.21394461
25Bladder cancer_Homo sapiens_hsa052191.21019953
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20350852
27Glioma_Homo sapiens_hsa052141.19959206
28Thyroid cancer_Homo sapiens_hsa052161.18962090
29Tight junction_Homo sapiens_hsa045301.13010858
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12631743
31Olfactory transduction_Homo sapiens_hsa047401.11120976
32ECM-receptor interaction_Homo sapiens_hsa045121.07930992
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.04132701
34GnRH signaling pathway_Homo sapiens_hsa049121.01317471
35Leukocyte transendothelial migration_Homo sapiens_hsa046700.97565450
36Wnt signaling pathway_Homo sapiens_hsa043100.95865076
37Dorso-ventral axis formation_Homo sapiens_hsa043200.94644464
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92043380
39ErbB signaling pathway_Homo sapiens_hsa040120.88731497
40Endometrial cancer_Homo sapiens_hsa052130.87669811
41Amoebiasis_Homo sapiens_hsa051460.86722384
42Ras signaling pathway_Homo sapiens_hsa040140.85487422
43MicroRNAs in cancer_Homo sapiens_hsa052060.85114676
44Tyrosine metabolism_Homo sapiens_hsa003500.83501388
45Non-small cell lung cancer_Homo sapiens_hsa052230.83259919
46Steroid biosynthesis_Homo sapiens_hsa001000.81608655
47Pertussis_Homo sapiens_hsa051330.81581742
48TGF-beta signaling pathway_Homo sapiens_hsa043500.78398677
49PPAR signaling pathway_Homo sapiens_hsa033200.76471485
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75804006
51Long-term potentiation_Homo sapiens_hsa047200.75792055
52Sphingolipid metabolism_Homo sapiens_hsa006000.72872823
53Protein digestion and absorption_Homo sapiens_hsa049740.71727021
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71653503
55T cell receptor signaling pathway_Homo sapiens_hsa046600.71646252
56Pancreatic secretion_Homo sapiens_hsa049720.71181035
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.71055322
58Renin secretion_Homo sapiens_hsa049240.70958465
59Caffeine metabolism_Homo sapiens_hsa002320.68265591
60Platelet activation_Homo sapiens_hsa046110.67047719
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65697550
62Hepatitis C_Homo sapiens_hsa051600.64360277
63Oxytocin signaling pathway_Homo sapiens_hsa049210.63006411
64Rap1 signaling pathway_Homo sapiens_hsa040150.62448235
65Estrogen signaling pathway_Homo sapiens_hsa049150.62302434
66Insulin resistance_Homo sapiens_hsa049310.62096276
67Focal adhesion_Homo sapiens_hsa045100.60921437
68Phototransduction_Homo sapiens_hsa047440.59377133
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59067801
70HTLV-I infection_Homo sapiens_hsa051660.58617110
71Gastric acid secretion_Homo sapiens_hsa049710.57976753
72Chronic myeloid leukemia_Homo sapiens_hsa052200.53905862
73Long-term depression_Homo sapiens_hsa047300.53662663
74beta-Alanine metabolism_Homo sapiens_hsa004100.53482686
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.52663803
76p53 signaling pathway_Homo sapiens_hsa041150.52249067
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50252250
78Pathways in cancer_Homo sapiens_hsa052000.50197086
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50053472
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49025293
81Renal cell carcinoma_Homo sapiens_hsa052110.48802445
82Tuberculosis_Homo sapiens_hsa051520.47630878
83Salmonella infection_Homo sapiens_hsa051320.47617302
84Prostate cancer_Homo sapiens_hsa052150.47589562
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44281759
86Prolactin signaling pathway_Homo sapiens_hsa049170.43617842
87Toxoplasmosis_Homo sapiens_hsa051450.42163094
88Insulin signaling pathway_Homo sapiens_hsa049100.41939807
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41327075
90Prion diseases_Homo sapiens_hsa050200.40566822
91Melanoma_Homo sapiens_hsa052180.40248424
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40162515
93Apoptosis_Homo sapiens_hsa042100.39871125
94Notch signaling pathway_Homo sapiens_hsa043300.38543006
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.37767473
96Nitrogen metabolism_Homo sapiens_hsa009100.36697944
97Dilated cardiomyopathy_Homo sapiens_hsa054140.35851020
98Retinol metabolism_Homo sapiens_hsa008300.35820989
99Chemical carcinogenesis_Homo sapiens_hsa052040.34446915
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33974216

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