KRT84

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)7.49511987
2cell wall macromolecule metabolic process (GO:0044036)7.49511987
3peptide cross-linking (GO:0018149)6.85451987
4citrulline biosynthetic process (GO:0019240)5.75433362
5keratinocyte differentiation (GO:0030216)5.36969868
6intermediate filament organization (GO:0045109)5.34438915
7notochord development (GO:0030903)5.31868955
8regulation of female gonad development (GO:2000194)5.00262282
9piRNA metabolic process (GO:0034587)4.96697083
10regulation of meiosis (GO:0040020)4.67542827
11hair follicle morphogenesis (GO:0031069)4.66735131
12desmosome organization (GO:0002934)4.46489749
13establishment of skin barrier (GO:0061436)4.36918689
14* regulation of keratinocyte differentiation (GO:0045616)4.28647278
15meiotic chromosome segregation (GO:0045132)4.28499087
16mitotic metaphase plate congression (GO:0007080)4.21403284
17muscle organ morphogenesis (GO:0048644)4.20816292
18regulation of meiosis I (GO:0060631)4.18313910
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.05993621
20regulation of meiotic cell cycle (GO:0051445)4.02948564
21female gamete generation (GO:0007292)4.01789527
22mitotic chromosome condensation (GO:0007076)3.98904494
23regulation of water loss via skin (GO:0033561)3.91386672
24negative regulation of reproductive process (GO:2000242)3.89037030
25epidermal cell differentiation (GO:0009913)3.85349475
26virion attachment to host cell (GO:0019062)3.83379656
27adhesion of symbiont to host cell (GO:0044650)3.83379656
28tooth mineralization (GO:0034505)3.83295428
29negative regulation of hormone metabolic process (GO:0032351)3.83181456
30negative regulation of hormone biosynthetic process (GO:0032353)3.83181456
31regulation of sister chromatid cohesion (GO:0007063)3.77001891
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76312623
33negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.73587269
34DNA damage induced protein phosphorylation (GO:0006975)3.69879604
35phosphatidylinositol acyl-chain remodeling (GO:0036149)3.67653310
36negative regulation of meiosis (GO:0045835)3.62840453
37intestinal epithelial cell development (GO:0060576)3.60846718
38peptidyl-arginine modification (GO:0018195)3.58034206
39DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.57195337
40oocyte maturation (GO:0001556)3.50568831
41metaphase plate congression (GO:0051310)3.50289717
42regulation of histone H3-K27 methylation (GO:0061085)3.43616768
43regulation of exit from mitosis (GO:0007096)3.40522458
44coronary vasculature morphogenesis (GO:0060977)3.39549602
45DNA damage response, signal transduction resulting in transcription (GO:0042772)3.39132083
46histone H2A monoubiquitination (GO:0035518)3.37960675
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37786065
48* epidermis development (GO:0008544)3.33655387
49mitotic sister chromatid segregation (GO:0000070)3.33452500
50regulation of RIG-I signaling pathway (GO:0039535)3.33146213
51negative regulation of meiotic cell cycle (GO:0051447)3.32482475
52regulation of cardioblast proliferation (GO:0003264)3.30337180
53regulation of secondary heart field cardioblast proliferation (GO:0003266)3.30337180
54intermediate filament cytoskeleton organization (GO:0045104)3.28742246
55myoblast migration (GO:0051451)3.27236395
56citrulline metabolic process (GO:0000052)3.21614836
57intermediate filament-based process (GO:0045103)3.20017802
58histone H2A ubiquitination (GO:0033522)3.16135794
59sphingosine metabolic process (GO:0006670)3.14851726
60maturation of 5.8S rRNA (GO:0000460)3.14811463
61protein K6-linked ubiquitination (GO:0085020)3.13965669
62male meiosis (GO:0007140)3.13806273
63monoubiquitinated protein deubiquitination (GO:0035520)3.12780153
64negative regulation of circadian rhythm (GO:0042754)3.11868247
65regulation of transforming growth factor beta2 production (GO:0032909)3.09727984
66adhesion of symbiont to host (GO:0044406)3.09621954
67* regulation of epidermal cell differentiation (GO:0045604)3.02404654
68meiotic cell cycle (GO:0051321)3.01836896
69positive regulation of meiotic cell cycle (GO:0051446)3.01248618
70negative regulation of smooth muscle cell differentiation (GO:0051151)3.00576170
71regulation of glucocorticoid metabolic process (GO:0031943)2.98449102
72regulation of hippo signaling (GO:0035330)2.95572148
73cranial nerve morphogenesis (GO:0021602)2.93810021
74replication fork processing (GO:0031297)2.91540815
75establishment of chromosome localization (GO:0051303)2.90310426
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88378230
77positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.88152780
78columnar/cuboidal epithelial cell development (GO:0002066)2.86084320
79type B pancreatic cell development (GO:0003323)2.82564969
80regulation of Cdc42 GTPase activity (GO:0043088)2.80957130
81regulation of keratinocyte proliferation (GO:0010837)2.80365084
82* regulation of epidermis development (GO:0045682)2.79725742
83hemidesmosome assembly (GO:0031581)2.78883429
84outer ear morphogenesis (GO:0042473)2.77859745
85negative regulation of keratinocyte proliferation (GO:0010839)2.77008335
86female gonad development (GO:0008585)2.76603605
87regulation of retinoic acid receptor signaling pathway (GO:0048385)2.76095717
88regulation of mononuclear cell migration (GO:0071675)2.76078216
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73329042
90diol metabolic process (GO:0034311)2.73108461
91glycerophospholipid catabolic process (GO:0046475)2.72544236
92* molting cycle process (GO:0022404)2.70802110
93* hair cycle process (GO:0022405)2.70802110
94DNA methylation involved in gamete generation (GO:0043046)2.70667541
95base-excision repair, AP site formation (GO:0006285)2.67756245
96negative regulation of Ras GTPase activity (GO:0034261)2.66186836
97lymph vessel development (GO:0001945)2.65461087
98hair cycle (GO:0042633)13.9348743
99molting cycle (GO:0042303)13.9348743
100keratinization (GO:0031424)13.0550993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.98672311
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.65303636
3KAP1_22055183_ChIP-Seq_ESCs_Mouse3.16016777
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.78989157
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.27008359
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26516463
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23350011
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.23014533
9AR_21909140_ChIP-Seq_LNCAP_Human2.08060829
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07270598
11ERG_20517297_ChIP-Seq_VCAP_Human2.04693921
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.93139934
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.89759624
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88580250
15GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.85230380
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.83626811
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82237800
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81861194
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76853766
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70950689
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.69307194
22* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.68465769
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.67522867
24GATA6_21074721_ChIP-Seq_CACO-2_Human1.65950051
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.63564096
26CTCF_20526341_ChIP-Seq_ESCs_Human1.52798461
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.52789266
28* NANOG_20526341_ChIP-Seq_ESCs_Human1.44940679
29NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.40746234
30ATF3_27146783_Chip-Seq_COLON_Human1.39182803
31CTCF_27219007_Chip-Seq_Bcells_Human1.37313576
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35508767
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35289823
34NFYA_21822215_ChIP-Seq_K562_Human1.31810908
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25748130
36* GATA3_21867929_ChIP-Seq_TH1_Mouse1.24981187
37CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23542204
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.21529725
39MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.21247483
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.20664816
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20450645
42HNFA_21074721_ChIP-Seq_CACO-2_Human1.17814603
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17454341
44MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17220317
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.12493589
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.12359512
47CJUN_26792858_Chip-Seq_BT549_Human1.12266848
48RBPJ_21746931_ChIP-Seq_IB4_Human1.12167313
49* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12085762
50OCT1_27270436_Chip-Seq_PROSTATE_Human1.11396781
51TP63_22573176_ChIP-Seq_HFKS_Human1.10116016
52RACK7_27058665_Chip-Seq_MCF-7_Human1.09611203
53CSB_26484114_Chip-Seq_FIBROBLAST_Human1.08735161
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08595671
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08252610
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07809739
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06161071
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04612436
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04068546
60PHF8_20622853_ChIP-Seq_HELA_Human1.03987666
61GATA3_24758297_ChIP-Seq_MCF-7_Human1.03737862
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03463312
63P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03056282
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02411948
65IGF1R_20145208_ChIP-Seq_DFB_Human1.02390231
66TBL1_22424771_ChIP-Seq_293T_Human1.01880660
67TP63_23658742_ChIP-Seq_EP156T_Human1.01691571
68PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99412180
69RNF2_27304074_Chip-Seq_NSC_Mouse0.99344379
70RUNX1_27514584_Chip-Seq_MCF-7_Human0.99285141
71SMC4_20622854_ChIP-Seq_HELA_Human0.98373197
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97906836
73ETV1_20927104_ChIP-Seq_GIST48_Human0.96826348
74P53_21459846_ChIP-Seq_SAOS-2_Human0.95789113
75BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94849089
76P68_20966046_ChIP-Seq_HELA_Human0.94732365
77SPI1_26923725_Chip-Seq_HPCs_Mouse0.94516100
78BCOR_27268052_Chip-Seq_Bcells_Human0.92192915
79E2F1_20622854_ChIP-Seq_HELA_Human0.92124593
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92001361
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91628404
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.91193316
83RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91112757
84AR_21572438_ChIP-Seq_LNCaP_Human0.90786673
85KLF5_25053715_ChIP-Seq_YYC3_Human0.90487140
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90134979
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89851545
88VDR_22108803_ChIP-Seq_LS180_Human0.87862455
89CTCF_18555785_Chip-Seq_ESCs_Mouse0.87778590
90RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87744669
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.87476120
92KLF4_18555785_Chip-Seq_ESCs_Mouse0.86669158
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85171237
94NFYB_21822215_ChIP-Seq_K562_Human0.83728616
95RAC3_21632823_ChIP-Seq_H3396_Human0.83444604
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83108670
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82950513
98SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82471321
99ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81863106
100CDX2_22108803_ChIP-Seq_LS180_Human0.81665453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.12615482
2MP0002796_impaired_skin_barrier4.45887394
3MP0003646_muscle_fatigue4.44246963
4MP0005451_abnormal_body_composition4.25651449
5MP0002098_abnormal_vibrissa_morphology3.51285832
6MP0005275_abnormal_skin_tensile3.31159247
7MP0010234_abnormal_vibrissa_follicle3.31014969
8MP0002102_abnormal_ear_morphology3.27945971
9MP0002234_abnormal_pharynx_morphology3.26673537
10MP0000647_abnormal_sebaceous_gland3.12173675
11MP0002249_abnormal_larynx_morphology2.71375415
12MP0003718_maternal_effect2.70512719
13MP0005501_abnormal_skin_physiology2.66549332
14MP0004185_abnormal_adipocyte_glucose2.47402407
15MP0000383_abnormal_hair_follicle2.43351811
16MP0000427_abnormal_hair_cycle2.33080334
17MP0003693_abnormal_embryo_hatching2.28235347
18MP0003453_abnormal_keratinocyte_physiol2.22593315
19MP0010678_abnormal_skin_adnexa2.21520162
20MP0000467_abnormal_esophagus_morphology2.14879365
21MP0000762_abnormal_tongue_morphology2.14014948
22MP0003705_abnormal_hypodermis_morpholog2.13300486
23MP0000377_abnormal_hair_follicle2.08085610
24MP0000678_abnormal_parathyroid_gland2.00015802
25MP0002653_abnormal_ependyma_morphology1.99581496
26MP0000566_synostosis1.94214923
27MP0001216_abnormal_epidermal_layer1.87387801
28MP0008877_abnormal_DNA_methylation1.84774639
29MP0001346_abnormal_lacrimal_gland1.75823418
30MP0010030_abnormal_orbit_morphology1.68904404
31MP0002254_reproductive_system_inflammat1.63498702
32MP0000462_abnormal_digestive_system1.60461795
33MP0003699_abnormal_female_reproductive1.50638578
34MP0010771_integument_phenotype1.48533635
35MP0002060_abnormal_skin_morphology1.46968276
36MP0001119_abnormal_female_reproductive1.38604047
37MP0005395_other_phenotype1.36617981
38MP0003937_abnormal_limbs/digits/tail_de1.33304556
39MP0010094_abnormal_chromosome_stability1.32882075
40MP0003755_abnormal_palate_morphology1.32744023
41MP0001243_abnormal_dermal_layer1.30524499
42MP0001849_ear_inflammation1.27495298
43MP0004957_abnormal_blastocyst_morpholog1.25575340
44MP0000367_abnormal_coat/_hair1.23640489
45MP0003077_abnormal_cell_cycle1.19248148
46MP0000751_myopathy1.19081506
47MP0003111_abnormal_nucleus_morphology1.18384865
48MP0004264_abnormal_extraembryonic_tissu1.14678490
49MP0004947_skin_inflammation1.11605295
50MP0003315_abnormal_perineum_morphology1.09331912
51MP0000733_abnormal_muscle_development1.07483091
52MP0002095_abnormal_skin_pigmentation1.00066438
53MP0000653_abnormal_sex_gland0.97304008
54MP0008932_abnormal_embryonic_tissue0.97021052
55MP0004036_abnormal_muscle_relaxation0.94500812
56MP0001929_abnormal_gametogenesis0.91922665
57MP0002210_abnormal_sex_determination0.89600298
58MP0002084_abnormal_developmental_patter0.89085772
59MP0008057_abnormal_DNA_replication0.88938383
60MP0009931_abnormal_skin_appearance0.88736937
61MP0005310_abnormal_salivary_gland0.88545546
62MP0002177_abnormal_outer_ear0.86633881
63MP0000490_abnormal_crypts_of0.86301025
64MP0009250_abnormal_appendicular_skeleto0.85940437
65MP0002085_abnormal_embryonic_tissue0.85191599
66MP0005408_hypopigmentation0.83569918
67MP0002106_abnormal_muscle_physiology0.83294226
68MP0004484_altered_response_of0.81887121
69MP0000470_abnormal_stomach_morphology0.81679630
70MP0000350_abnormal_cell_proliferation0.77177342
71MP0001851_eye_inflammation0.76907757
72MP0000613_abnormal_salivary_gland0.76055724
73MP0002877_abnormal_melanocyte_morpholog0.72837000
74MP0001730_embryonic_growth_arrest0.69402717
75MP0003950_abnormal_plasma_membrane0.68480744
76MP0004510_myositis0.68159364
77MP0009053_abnormal_anal_canal0.67986186
78MP0004145_abnormal_muscle_electrophysio0.67481171
79MP0005666_abnormal_adipose_tissue0.67461806
80MP0001697_abnormal_embryo_size0.66438658
81MP0003935_abnormal_craniofacial_develop0.65949553
82MP0005257_abnormal_intraocular_pressure0.65305788
83MP0002932_abnormal_joint_morphology0.64953873
84MP0002282_abnormal_trachea_morphology0.64887140
85MP0002332_abnormal_exercise_endurance0.64719939
86MP0002111_abnormal_tail_morphology0.63154082
87MP0003123_paternal_imprinting0.62033818
88MP0002116_abnormal_craniofacial_bone0.61190554
89MP0003566_abnormal_cell_adhesion0.61162082
90MP0001340_abnormal_eyelid_morphology0.60278231
91MP0000759_abnormal_skeletal_muscle0.58913484
92MP0002161_abnormal_fertility/fecundity0.57786966
93MP0000432_abnormal_head_morphology0.57382907
94MP0009278_abnormal_bone_marrow0.55748015
95MP0001145_abnormal_male_reproductive0.54848417
96MP0000627_abnormal_mammary_gland0.54448909
97MP0001672_abnormal_embryogenesis/_devel0.54418562
98MP0005380_embryogenesis_phenotype0.54418562
99MP0000639_abnormal_adrenal_gland0.54243398
100MP0005248_abnormal_Harderian_gland0.53478659

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)8.60737172
2Hypotrichosis (HP:0001006)8.49690303
3Woolly hair (HP:0002224)5.94301799
4Pili torti (HP:0003777)5.43915912
5Abnormality of hair growth rate (HP:0011363)5.23364795
6Slow-growing hair (HP:0002217)5.23364795
7Male infertility (HP:0003251)5.02554352
8Abnormality of the aortic arch (HP:0012303)4.83507482
9Unilateral renal agenesis (HP:0000122)4.65590612
10Brittle hair (HP:0002299)4.62995337
11Nail dystrophy (HP:0008404)4.50069886
12Increased IgE level (HP:0003212)4.48287856
13Right ventricular cardiomyopathy (HP:0011663)3.85369238
14Abnormality of nail color (HP:0100643)3.67108279
15Tetany (HP:0001281)3.62272492
16Alopecia of scalp (HP:0002293)3.31723030
17Facial hemangioma (HP:0000329)3.26874152
18Double outlet right ventricle (HP:0001719)3.22865501
19Congenital malformation of the right heart (HP:0011723)3.22865501
20Abnormal hair laboratory examination (HP:0003328)3.22734384
21Onycholysis (HP:0001806)3.18079076
22Muscle fiber inclusion bodies (HP:0100299)3.15655240
23Lip pit (HP:0100267)3.05158222
24Calcaneovalgus deformity (HP:0001848)3.02275205
25Autoimmune thrombocytopenia (HP:0001973)2.98183229
26Fine hair (HP:0002213)2.94873839
27Plantar hyperkeratosis (HP:0007556)2.91323920
28Palmoplantar hyperkeratosis (HP:0000972)2.90884549
29Round ear (HP:0100830)2.88087798
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.85710840
31Distal arthrogryposis (HP:0005684)2.85670385
32Fragile nails (HP:0001808)2.78847179
33Abnormality of chromosome segregation (HP:0002916)2.74157263
34Palmar hyperkeratosis (HP:0010765)2.71503715
35Deformed tarsal bones (HP:0008119)2.68201095
36Neck muscle weakness (HP:0000467)2.66068679
37Abnormality of the parathyroid morphology (HP:0011766)2.65194228
38Ulnar deviation of the wrist (HP:0003049)2.65017099
39Exercise-induced myalgia (HP:0003738)2.64545762
40Muscle fiber splitting (HP:0003555)2.60199249
41Nemaline bodies (HP:0003798)2.59251462
42Adrenal hypoplasia (HP:0000835)2.58305312
43Abnormality of the labia minora (HP:0012880)2.55101322
44Shawl scrotum (HP:0000049)2.53871758
45Absent phalangeal crease (HP:0006109)2.52091328
46Abnormality of the neuromuscular junction (HP:0003398)2.36201051
47Fatigable weakness (HP:0003473)2.36201051
48Type 1 muscle fiber predominance (HP:0003803)2.33175819
49Congenital ichthyosiform erythroderma (HP:0007431)2.32662363
50Milia (HP:0001056)2.31335178
51Ectropion (HP:0000656)2.31271588
52Rib fusion (HP:0000902)2.30385532
53Aplasia/Hypoplasia of the patella (HP:0006498)2.24352521
54Increased connective tissue (HP:0009025)2.19220446
55Follicular hyperkeratosis (HP:0007502)2.16035163
56Patellar aplasia (HP:0006443)2.12005759
57Posterior embryotoxon (HP:0000627)2.11521652
58Abnormality of placental membranes (HP:0011409)2.09753415
59Amniotic constriction ring (HP:0009775)2.09753415
60Premature ovarian failure (HP:0008209)2.09631741
61Curly hair (HP:0002212)2.08309299
62Hyperthyroidism (HP:0000836)2.07711008
63Concave nail (HP:0001598)2.06428594
64Palmoplantar keratoderma (HP:0000982)2.06106204
65Papillary thyroid carcinoma (HP:0002895)2.03156394
66Abnormality of lateral ventricle (HP:0030047)2.01633259
67Capillary hemangiomas (HP:0005306)2.00741363
68Abnormality of the line of Schwalbe (HP:0008048)1.98351036
69Breast hypoplasia (HP:0003187)1.97860152
70Abnormal finger flexion creases (HP:0006143)1.95897346
71Atelectasis (HP:0100750)1.94219358
72Distal lower limb muscle weakness (HP:0009053)1.93044315
73Corneal erosion (HP:0200020)1.91467062
74Chromsome breakage (HP:0040012)1.88953737
75Distal lower limb amyotrophy (HP:0008944)1.88820930
76Hypoparathyroidism (HP:0000829)1.87249146
77Wrist flexion contracture (HP:0001239)1.87107454
78Flat capital femoral epiphysis (HP:0003370)1.82942511
79Abnormal blistering of the skin (HP:0008066)1.81388165
80Cholelithiasis (HP:0001081)1.81022623
81Erythroderma (HP:0001019)1.80940706
82Myopathic facies (HP:0002058)1.80783044
83Skin pits (HP:0100276)1.79925697
84Nonprogressive disorder (HP:0003680)1.79870527
85Infertility (HP:0000789)1.79114733
86Pustule (HP:0200039)1.73438325
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.70474575
88Hypoplasia of the fovea (HP:0007750)1.70474575
89Difficulty running (HP:0009046)1.69079174
90Periauricular skin pits (HP:0100277)1.69050089
91Preauricular pit (HP:0004467)1.69050089
92Microglossia (HP:0000171)1.68931736
93Aplasia/Hypoplasia of the breasts (HP:0010311)1.67128738
94Sparse eyelashes (HP:0000653)1.66481988
95Erythema (HP:0010783)1.66255895
96Blepharitis (HP:0000498)1.65833042
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65199740
98Areflexia of lower limbs (HP:0002522)1.65013131
99Ventricular tachycardia (HP:0004756)1.64634015
100Breast aplasia (HP:0100783)1.64336368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.77060053
2LATS25.03747726
3MAP3K65.01131484
4STK38L3.80756611
5ERBB43.06883598
6TAOK13.03800047
7KSR22.97550737
8MAPKAPK32.51487800
9MAP3K92.32513732
10TTN2.31279661
11EEF2K2.30451627
12MUSK2.27048712
13STK32.04567298
14PLK41.86554284
15TTK1.83000343
16RAF11.82702388
17PAK61.79719285
18TAOK31.76003440
19CDK81.71997094
20BRAF1.67611989
21OBSCN1.53824289
22PINK11.46442984
23PRKD21.44888087
24MAP3K131.42096795
25MOS1.39262712
26DMPK1.34971805
27TYRO31.34039596
28STK381.29564628
29CHEK21.27860737
30CDC71.23151936
31PRKD31.16377592
32KSR11.12645413
33NEK21.11637210
34PIK3CG1.07469271
35MELK1.06330124
36ABL21.04117646
37MAP3K111.01716545
38DYRK21.00288818
39TRIB30.97564178
40DDR20.97237219
41ARAF0.92922554
42TRPM70.89237106
43MAPK110.88005402
44RPS6KB20.82343994
45MAPKAPK50.80973312
46CDK90.75652583
47PLK10.74806625
48FGR0.74319358
49PRKAA20.74216546
50RPS6KA40.72408934
51ICK0.69439504
52STK100.67448817
53MAP3K50.67065679
54MAP3K80.66658725
55PRKAA10.66305920
56NTRK20.64433829
57EPHA20.62513455
58MAP2K40.62270694
59MAPK130.60080921
60MAPK150.56779082
61BMX0.56529265
62AURKB0.55363789
63MARK20.51495890
64MAP3K40.50882141
65NTRK10.47026040
66CDK70.46215113
67NEK10.45390002
68PIM10.44658842
69MAP3K10.44658180
70PAK30.43898486
71CSNK1G10.43476921
72BMPR20.40823127
73RET0.39033089
74ABL10.36074185
75DYRK30.34647829
76ATM0.34615074
77HIPK20.33067149
78CAMK2A0.32927040
79PHKG10.31202964
80PHKG20.31202964
81PDGFRA0.30619572
82FER0.29462686
83EPHB20.28780483
84PTK20.28297967
85MAP2K10.27433982
86CHEK10.26939846
87RPS6KA10.26361224
88CDK60.25246839
89AURKA0.23833682
90STK240.22520871
91JAK30.21958102
92EPHA30.19914593
93JAK20.19471413
94MAPKAPK20.17778034
95MATK0.17354659
96CDK10.16964130
97SGK10.16704933
98CDK20.15287175
99CSNK1E0.15115630
100CSNK1D0.14622873

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.30182820
2Linoleic acid metabolism_Homo sapiens_hsa005913.29706130
3Cell cycle_Homo sapiens_hsa041102.89566382
4Circadian rhythm_Homo sapiens_hsa047102.71280213
5Vitamin B6 metabolism_Homo sapiens_hsa007502.69341659
6Ovarian steroidogenesis_Homo sapiens_hsa049132.51846511
7RNA degradation_Homo sapiens_hsa030182.12238575
8TGF-beta signaling pathway_Homo sapiens_hsa043502.11516091
9Ether lipid metabolism_Homo sapiens_hsa005652.08009493
10Pancreatic cancer_Homo sapiens_hsa052122.01818619
11Basal transcription factors_Homo sapiens_hsa030221.98369281
12Fat digestion and absorption_Homo sapiens_hsa049751.91788168
13GnRH signaling pathway_Homo sapiens_hsa049121.91380352
14VEGF signaling pathway_Homo sapiens_hsa043701.86846555
15Oocyte meiosis_Homo sapiens_hsa041141.80936067
16p53 signaling pathway_Homo sapiens_hsa041151.79296255
17Dorso-ventral axis formation_Homo sapiens_hsa043201.74291365
18Salivary secretion_Homo sapiens_hsa049701.63808610
19Prolactin signaling pathway_Homo sapiens_hsa049171.62508061
20Base excision repair_Homo sapiens_hsa034101.58821463
21Hippo signaling pathway_Homo sapiens_hsa043901.53630692
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52931398
23MicroRNAs in cancer_Homo sapiens_hsa052061.42453680
24Adherens junction_Homo sapiens_hsa045201.41723801
25Notch signaling pathway_Homo sapiens_hsa043301.41663266
26Fatty acid biosynthesis_Homo sapiens_hsa000611.40136459
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36945464
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34619163
29Arachidonic acid metabolism_Homo sapiens_hsa005901.34019615
30Bladder cancer_Homo sapiens_hsa052191.33763480
31Histidine metabolism_Homo sapiens_hsa003401.33568869
32Choline metabolism in cancer_Homo sapiens_hsa052311.28414524
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28414207
34mTOR signaling pathway_Homo sapiens_hsa041501.26126024
35Phenylalanine metabolism_Homo sapiens_hsa003601.23937066
36Renal cell carcinoma_Homo sapiens_hsa052111.16480623
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.13625177
38Glycerolipid metabolism_Homo sapiens_hsa005611.12471155
39Colorectal cancer_Homo sapiens_hsa052101.11374527
40Arginine and proline metabolism_Homo sapiens_hsa003301.07764467
41beta-Alanine metabolism_Homo sapiens_hsa004101.06185325
42Endometrial cancer_Homo sapiens_hsa052131.05029857
43Glioma_Homo sapiens_hsa052141.03811818
44Chronic myeloid leukemia_Homo sapiens_hsa052201.02258286
45Fanconi anemia pathway_Homo sapiens_hsa034601.01159983
46Estrogen signaling pathway_Homo sapiens_hsa049150.99090939
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98332650
48Ras signaling pathway_Homo sapiens_hsa040140.97994575
49Thyroid cancer_Homo sapiens_hsa052160.94967488
50Small cell lung cancer_Homo sapiens_hsa052220.93347797
51Tight junction_Homo sapiens_hsa045300.86359726
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.84094999
53RNA transport_Homo sapiens_hsa030130.83071051
54Homologous recombination_Homo sapiens_hsa034400.82384713
55ErbB signaling pathway_Homo sapiens_hsa040120.81180534
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80992482
57Basal cell carcinoma_Homo sapiens_hsa052170.80930496
58Hedgehog signaling pathway_Homo sapiens_hsa043400.79751779
59Long-term depression_Homo sapiens_hsa047300.79642147
60Non-small cell lung cancer_Homo sapiens_hsa052230.79035402
61Wnt signaling pathway_Homo sapiens_hsa043100.77616629
62Prostate cancer_Homo sapiens_hsa052150.75842985
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73517658
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72618388
65FoxO signaling pathway_Homo sapiens_hsa040680.72604098
66Insulin signaling pathway_Homo sapiens_hsa049100.63445508
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62731602
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62228049
69Shigellosis_Homo sapiens_hsa051310.62001792
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58706124
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.58516603
72mRNA surveillance pathway_Homo sapiens_hsa030150.58178893
73MAPK signaling pathway_Homo sapiens_hsa040100.56920152
74Hepatitis B_Homo sapiens_hsa051610.55556601
75Melanoma_Homo sapiens_hsa052180.54902186
76Tyrosine metabolism_Homo sapiens_hsa003500.51876385
77Biosynthesis of amino acids_Homo sapiens_hsa012300.51783298
78Melanogenesis_Homo sapiens_hsa049160.51608630
79Glucagon signaling pathway_Homo sapiens_hsa049220.50387806
80AMPK signaling pathway_Homo sapiens_hsa041520.47626936
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46695443
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46145545
83Oxytocin signaling pathway_Homo sapiens_hsa049210.44648475
84Sphingolipid metabolism_Homo sapiens_hsa006000.42902429
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42835851
86Herpes simplex infection_Homo sapiens_hsa051680.41379051
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41374167
88Focal adhesion_Homo sapiens_hsa045100.37894291
89Acute myeloid leukemia_Homo sapiens_hsa052210.35567109
90HTLV-I infection_Homo sapiens_hsa051660.35337744
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.35113081
92Proteoglycans in cancer_Homo sapiens_hsa052050.34667268
93TNF signaling pathway_Homo sapiens_hsa046680.32359742
94RNA polymerase_Homo sapiens_hsa030200.32166374
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31099638
96Arginine biosynthesis_Homo sapiens_hsa002200.29062334
97Pathways in cancer_Homo sapiens_hsa052000.27286402
98Rap1 signaling pathway_Homo sapiens_hsa040150.27004662
99cAMP signaling pathway_Homo sapiens_hsa040240.26186663
100Insulin resistance_Homo sapiens_hsa049310.25226921

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