KRT85

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.93023644
2intermediate filament cytoskeleton organization (GO:0045104)9.57693245
3intermediate filament-based process (GO:0045103)9.30721454
4desmosome organization (GO:0002934)8.04413303
5establishment of skin barrier (GO:0061436)6.76867052
6peptide cross-linking (GO:0018149)6.03506440
7hair cycle process (GO:0022405)6.02742078
8molting cycle process (GO:0022404)6.02742078
9regulation of water loss via skin (GO:0033561)5.89720490
10* epidermis development (GO:0008544)5.62317102
11linoleic acid metabolic process (GO:0043651)5.61470702
12long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.28402103
13very long-chain fatty acid metabolic process (GO:0000038)5.10576869
14long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.96726013
15fatty-acyl-CoA biosynthetic process (GO:0046949)4.73966193
16keratinocyte differentiation (GO:0030216)4.66352594
17retinol metabolic process (GO:0042572)4.59274171
18hemidesmosome assembly (GO:0031581)4.17597343
19keratinocyte proliferation (GO:0043616)4.00285453
20hair cycle (GO:0042633)36.2836545
21molting cycle (GO:0042303)36.2836545
22multicellular organismal water homeostasis (GO:0050891)3.91792505
23fatty-acyl-CoA metabolic process (GO:0035337)3.88115156
24thioester biosynthetic process (GO:0035384)3.82424965
25acyl-CoA biosynthetic process (GO:0071616)3.82424965
26epidermal cell differentiation (GO:0009913)3.77500452
27positive regulation of keratinocyte differentiation (GO:0045618)3.66901703
28bundle of His cell to Purkinje myocyte communication (GO:0086069)3.54346805
29long-chain fatty acid biosynthetic process (GO:0042759)3.37818051
30primary alcohol metabolic process (GO:0034308)3.35154861
31alpha-linolenic acid metabolic process (GO:0036109)3.27084483
32water homeostasis (GO:0030104)3.19666723
33lipoxygenase pathway (GO:0019372)3.10706519
34phosphatidylserine acyl-chain remodeling (GO:0036150)3.09208828
35positive regulation of epidermal cell differentiation (GO:0045606)3.08561558
36skin morphogenesis (GO:0043589)3.06874656
37regulation of chemokine secretion (GO:0090196)3.05595926
38regulation of defense response to virus by host (GO:0050691)2.92853783
39positive regulation of epidermis development (GO:0045684)2.88521452
40positive regulation of chemokine secretion (GO:0090197)2.83632672
41phosphatidylinositol acyl-chain remodeling (GO:0036149)2.82759370
42triglyceride biosynthetic process (GO:0019432)2.78263245
43defense response to fungus (GO:0050832)2.65390669
44negative regulation of keratinocyte proliferation (GO:0010839)2.63010831
45acylglycerol biosynthetic process (GO:0046463)2.62207539
46neutral lipid biosynthetic process (GO:0046460)2.62207539
47regulation of sequestering of triglyceride (GO:0010889)2.59558720
48* epithelium development (GO:0060429)2.57523795
49virion attachment to host cell (GO:0019062)2.57496263
50adhesion of symbiont to host cell (GO:0044650)2.57496263
51regulation of keratinocyte differentiation (GO:0045616)2.56229105
52killing of cells of other organism (GO:0031640)2.55371487
53disruption of cells of other organism (GO:0044364)2.55371487
54primary alcohol catabolic process (GO:0034310)2.49920895
55hair follicle development (GO:0001942)2.43311935
56acyl-CoA metabolic process (GO:0006637)2.39845535
57thioester metabolic process (GO:0035383)2.39845535
58adhesion of symbiont to host (GO:0044406)2.29701509
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.27145856
60phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.16844167
61phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.16806546
62positive regulation of hair cycle (GO:0042635)2.10111420
63positive regulation of hair follicle development (GO:0051798)2.10111420
64carnitine metabolic process (GO:0009437)2.05654544
65phosphatidylserine metabolic process (GO:0006658)2.05629692
66unsaturated fatty acid biosynthetic process (GO:0006636)2.02098021
67regulation of epidermal cell differentiation (GO:0045604)2.00182752
68intermediate filament organization (GO:0045109)15.2680022
69hair follicle morphogenesis (GO:0031069)10.6454796
70fatty acid elongation (GO:0030497)10.2958955
71phosphatidylcholine acyl-chain remodeling (GO:0036151)1.96947309
72aging (GO:0007568)1.94000803
73regulation of hair cycle (GO:0042634)1.92681224
74ectoderm development (GO:0007398)1.92569396
75fatty acid biosynthetic process (GO:0006633)1.92538375
76gap junction assembly (GO:0016264)1.83476086
77ethanol metabolic process (GO:0006067)1.82643086
78alditol phosphate metabolic process (GO:0052646)1.80630640
79epithelial cell-cell adhesion (GO:0090136)1.80386890
80response to phenylpropanoid (GO:0080184)1.79043480
81regulation of epidermis development (GO:0045682)1.77997180
82regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)1.76871217
83one-carbon compound transport (GO:0019755)1.75092239
84skin development (GO:0043588)1.74762856
85negative regulation of execution phase of apoptosis (GO:1900118)1.74019170
86regulation of glomerular filtration (GO:0003093)1.71286047
87sleep (GO:0030431)1.68276691
88cellular response to interleukin-15 (GO:0071350)1.68149982
89negative regulation of cell killing (GO:0031342)1.66829762
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.66829762
91phosphatidic acid biosynthetic process (GO:0006654)1.63828011
92phosphatidic acid metabolic process (GO:0046473)1.63828011
93response to fungus (GO:0009620)1.58991718
94lateral sprouting from an epithelium (GO:0060601)1.58894648
95lymph node development (GO:0048535)1.58095370
96regulation of keratinocyte proliferation (GO:0010837)1.55593782
97regulation of phospholipase A2 activity (GO:0032429)1.55168780
98keratinocyte development (GO:0003334)1.50621507
99diterpenoid metabolic process (GO:0016101)1.48637861
100sphingoid metabolic process (GO:0046519)1.48185082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.81187093
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.21494415
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.86063044
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.12707516
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98881828
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.63351328
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.09158987
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat14.3104087
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97572003
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86943484
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86943484
12CTCF_20526341_ChIP-Seq_ESCs_Human1.84216722
13SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80717329
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.79498077
15ERG_20517297_ChIP-Seq_VCAP_Human1.76153214
16BCOR_27268052_Chip-Seq_Bcells_Human1.70606418
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.64381701
18E2F1_20622854_ChIP-Seq_HELA_Human1.63175002
19P68_20966046_ChIP-Seq_HELA_Human1.61972448
20LXR_22292898_ChIP-Seq_THP-1_Human1.60532493
21BCL6_27268052_Chip-Seq_Bcells_Human1.59935475
22TP63_22573176_ChIP-Seq_HFKS_Human1.58662110
23YY1_22570637_ChIP-Seq_MALME-3M_Human1.50328016
24P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.47861619
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42181095
26SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41491138
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39283937
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32946736
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29094522
30ZNF263_19887448_ChIP-Seq_K562_Human1.28890754
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28061168
32TP63_23658742_ChIP-Seq_EP156T_Human1.20017106
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.19549262
34CSB_26484114_Chip-Seq_FIBROBLAST_Human1.19116037
35RACK7_27058665_Chip-Seq_MCF-7_Human1.18931157
36PHF8_20622854_ChIP-Seq_HELA_Human1.15080760
37UBF1/2_26484160_Chip-Seq_HMECs_Human1.14086494
38* TAF2_19829295_ChIP-Seq_ESCs_Human1.12640759
39CTCF_27219007_Chip-Seq_Bcells_Human1.10819750
40FOXH1_21741376_ChIP-Seq_ESCs_Human1.10758447
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09811581
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.09388338
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.08193581
44GATA4_25053715_ChIP-Seq_YYC3_Human1.06864579
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.05352967
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99133155
47GATA6_21074721_ChIP-Seq_CACO-2_Human0.98753567
48ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98354508
49SMC4_20622854_ChIP-Seq_HELA_Human0.97563126
50SA1_27219007_Chip-Seq_ERYTHROID_Human0.97509955
51RUNX1_27514584_Chip-Seq_MCF-7_Human0.96720207
52RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96192016
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94859879
54STAT1_20625510_ChIP-Seq_HELA_Human0.93401559
55FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93057136
56FOXA1_25329375_ChIP-Seq_VCAP_Human0.93057136
57P300_27268052_Chip-Seq_Bcells_Human0.91962305
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91211731
59SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88821758
60ATF3_27146783_Chip-Seq_COLON_Human0.86824432
61P53_21459846_ChIP-Seq_SAOS-2_Human0.84550122
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82041901
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81882330
64PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80629882
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80032805
66AHR_22903824_ChIP-Seq_MCF-7_Human0.79964034
67ESR1_20079471_ChIP-ChIP_T-47D_Human0.79486795
68SA1_27219007_Chip-Seq_Bcells_Human0.77730746
69SPI1_20517297_ChIP-Seq_HL60_Human0.76406987
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75308392
71TP53_20018659_ChIP-ChIP_R1E_Mouse0.74738961
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74632646
73KLF5_25053715_ChIP-Seq_YYC3_Human0.74575115
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74463970
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.73827072
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73823882
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73369937
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.70064862
79ERA_21632823_ChIP-Seq_H3396_Human0.69813003
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67002091
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.66947159
82RXR_22108803_ChIP-Seq_LS180_Human0.63546245
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.63377133
84TBX20_22328084_ChIP-Seq_HEART_Mouse0.63309026
85TBX20_22080862_ChIP-Seq_HEART_Mouse0.63309026
86KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63120694
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.62395646
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.61742103
89CEBPB_22108803_ChIP-Seq_LS180_Human0.60701598
90RXR_22158963_ChIP-Seq_LIVER_Mouse0.60429623
91MYC_19829295_ChIP-Seq_ESCs_Human0.60266514
92SMAD4_21741376_ChIP-Seq_ESCs_Human0.59581772
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.59263995
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.59229301
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.58814722
96ETS1_21867929_ChIP-Seq_TH2_Mouse0.58022837
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57829916
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.57794132
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56849869
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.56642992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000647_abnormal_sebaceous_gland7.84104877
2MP0002098_abnormal_vibrissa_morphology6.81018541
3MP0000579_abnormal_nail_morphology5.98958130
4MP0005275_abnormal_skin_tensile5.77470751
5MP0002796_impaired_skin_barrier5.71935958
6MP0004381_abnormal_hair_follicle4.91028203
7MP0000377_abnormal_hair_follicle4.10723096
8MP0010234_abnormal_vibrissa_follicle4.01407071
9MP0005501_abnormal_skin_physiology3.23566732
10MP0009379_abnormal_foot_pigmentation3.22182757
11MP0000383_abnormal_hair_follicle3.08075886
12MP0005377_hearing/vestibular/ear_phenot3.06434113
13MP0003878_abnormal_ear_physiology3.06434113
14MP0010678_abnormal_skin_adnexa2.95046136
15MP0004947_skin_inflammation2.90445878
16MP0005075_abnormal_melanosome_morpholog2.61983868
17MP0001216_abnormal_epidermal_layer2.56868363
18MP0003453_abnormal_keratinocyte_physiol2.54030488
19MP0000367_abnormal_coat/_hair2.35521752
20MP0002060_abnormal_skin_morphology2.27057608
21MP0001243_abnormal_dermal_layer2.23335010
22MP0000427_abnormal_hair_cycle2.22457877
23MP0010771_integument_phenotype2.16126679
24MP0004885_abnormal_endolymph1.91332397
25MP0002095_abnormal_skin_pigmentation1.80296356
26MP0003705_abnormal_hypodermis_morpholog1.80194334
27MP0001661_extended_life_span1.70694074
28MP0009931_abnormal_skin_appearance1.56853440
29MP0005409_darkened_coat_color1.50694820
30MP0003011_delayed_dark_adaptation1.45574602
31MP0000467_abnormal_esophagus_morphology1.35449544
32MP0001188_hyperpigmentation1.28547504
33MP0003300_gastrointestinal_ulcer1.13141608
34MP0001191_abnormal_skin_condition1.11899985
35MP0000566_synostosis1.11440731
36MP0006035_abnormal_mitochondrial_morpho0.94827570
37MP0003941_abnormal_skin_development0.89376322
38MP0005647_abnormal_sex_gland0.87406805
39MP0000762_abnormal_tongue_morphology0.84735813
40MP0005174_abnormal_tail_pigmentation0.83993787
41MP0002970_abnormal_white_adipose0.78128853
42MP0003763_abnormal_thymus_physiology0.78026794
43MP0000015_abnormal_ear_pigmentation0.77934561
44MP0003566_abnormal_cell_adhesion0.69860695
45MP0001851_eye_inflammation0.59040213
46MP0005671_abnormal_response_to0.58491043
47MP0004264_abnormal_extraembryonic_tissu0.58427807
48MP0003191_abnormal_cellular_cholesterol0.58182625
49MP0009780_abnormal_chondrocyte_physiolo0.56208974
50MP0001485_abnormal_pinna_reflex0.51895058
51MP0004782_abnormal_surfactant_physiolog0.49601457
52MP0002282_abnormal_trachea_morphology0.47375491
53MP0000465_gastrointestinal_hemorrhage0.46312759
54MP0000685_abnormal_immune_system0.46090923
55MP0010030_abnormal_orbit_morphology0.45921766
56MP0002877_abnormal_melanocyte_morpholog0.45239507
57MP0003638_abnormal_response/metabolism_0.44135718
58MP0004185_abnormal_adipocyte_glucose0.39428341
59MP0009053_abnormal_anal_canal0.37686504
60MP0000627_abnormal_mammary_gland0.35977397
61MP0001784_abnormal_fluid_regulation0.34935572
62MP0004858_abnormal_nervous_system0.33271430
63MP0000358_abnormal_cell_content/0.22499055
64MP0001919_abnormal_reproductive_system0.22383734
65MP0001340_abnormal_eyelid_morphology0.22191153
66MP0001765_abnormal_ion_homeostasis0.21298352
67MP0005023_abnormal_wound_healing0.20950679
68MP0004019_abnormal_vitamin_homeostasis0.19890425
69MP0005452_abnormal_adipose_tissue0.18587048
70MP0001881_abnormal_mammary_gland0.18254036
71MP0001905_abnormal_dopamine_level0.17442984
72MP0002006_tumorigenesis0.16830882
73MP0000858_altered_metastatic_potential0.15706698
74MP0009333_abnormal_splenocyte_physiolog0.15670095
75MP0002177_abnormal_outer_ear0.14225010
76MP0000462_abnormal_digestive_system0.13988224
77MP0004742_abnormal_vestibular_system0.13551576
78MP0003724_increased_susceptibility_to0.13308280
79MP0005535_abnormal_body_temperature0.13212087
80MP0000537_abnormal_urethra_morphology0.13029403
81MP0002234_abnormal_pharynx_morphology0.12615644
82MP0001984_abnormal_olfaction0.12399918
83MP0002139_abnormal_hepatobiliary_system0.12373396
84MP0001853_heart_inflammation0.12223050
85MP0001533_abnormal_skeleton_physiology0.11334000
86MP0001849_ear_inflammation0.08760588
87MP0002148_abnormal_hypersensitivity_rea0.08630979
88MP0005666_abnormal_adipose_tissue0.08558996
89MP0002111_abnormal_tail_morphology0.07882897
90MP0003315_abnormal_perineum_morphology0.07461429
91MP0003879_abnormal_hair_cell0.06171743
92MP0002118_abnormal_lipid_homeostasis0.06088443
93MP0004043_abnormal_pH_regulation0.05007418
94MP0005000_abnormal_immune_tolerance0.04378452
95MP0002166_altered_tumor_susceptibility0.04196405
96MP0000750_abnormal_muscle_regeneration0.04185171
97MP0006072_abnormal_retinal_apoptosis0.03773359
98MP0005390_skeleton_phenotype0.03660560
99MP0002163_abnormal_gland_morphology0.03441047
100MP0003436_decreased_susceptibility_to0.03187581

Predicted human phenotypes

RankGene SetZ-score
1* Brittle hair (HP:0002299)9.37796619
2* Pili torti (HP:0003777)7.25788079
3Abnormality of nail color (HP:0100643)6.89981051
4Dry hair (HP:0011359)6.84326962
5Increased IgE level (HP:0003212)6.56771267
6* Onycholysis (HP:0001806)6.11049845
7Fine hair (HP:0002213)5.99220451
8Palmoplantar hyperkeratosis (HP:0000972)5.97072816
9Palmar hyperkeratosis (HP:0010765)5.63435623
10Erythema (HP:0010783)5.12310741
11* Nail dystrophy (HP:0008404)5.06244377
12Plantar hyperkeratosis (HP:0007556)4.94360338
13Follicular hyperkeratosis (HP:0007502)4.90115033
14Alopecia of scalp (HP:0002293)4.85476114
15* Abnormal hair laboratory examination (HP:0003328)4.85160569
16Erythroderma (HP:0001019)4.66565911
17Thick nail (HP:0001805)4.62943791
18Sparse eyelashes (HP:0000653)4.50316613
19Abnormality of secondary sexual hair (HP:0009888)4.45630482
20Abnormality of the axillary hair (HP:0100134)4.45630482
21Congenital ichthyosiform erythroderma (HP:0007431)4.39292986
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.20345056
23Abnormality of the pupil (HP:0000615)3.88339926
24Congenital, generalized hypertrichosis (HP:0004540)3.79189232
25Fragile nails (HP:0001808)3.43231882
26Corneal erosion (HP:0200020)2.97457990
27Oral leukoplakia (HP:0002745)2.84244160
28Abnormal blistering of the skin (HP:0008066)2.82344043
29Right ventricular cardiomyopathy (HP:0011663)2.75735914
30Conjunctival hamartoma (HP:0100780)2.72917444
31Milia (HP:0001056)2.66380690
32Parakeratosis (HP:0001036)2.63673038
33Ridged nail (HP:0001807)2.59590100
34Palmoplantar keratoderma (HP:0000982)2.56601684
35Hypohidrosis (HP:0000966)2.42341847
36Blepharitis (HP:0000498)2.24961187
37Coarse hair (HP:0002208)2.16699281
38Pruritus (HP:0000989)2.09984528
39Fatigable weakness (HP:0003473)2.00513647
40Abnormality of the neuromuscular junction (HP:0003398)2.00513647
41Woolly hair (HP:0002224)12.4369818
42Slow-growing hair (HP:0002217)12.4346596
43Abnormality of hair growth rate (HP:0011363)12.4346596
44Hypotrichosis (HP:0001006)12.1125408
45Sparse scalp hair (HP:0002209)1.93989332
46* Absent hair (HP:0002298)1.91370805
47Acanthosis nigricans (HP:0000956)1.76535985
48Gangrene (HP:0100758)1.74681797
49Urticaria (HP:0001025)1.74447783
50Hamartoma of the eye (HP:0010568)1.73817502
51Furrowed tongue (HP:0000221)1.70507846
52Hypergammaglobulinemia (HP:0010702)1.68800130
53Conical tooth (HP:0000698)1.64311849
54Natal tooth (HP:0000695)1.60722260
55Advanced eruption of teeth (HP:0006288)1.58605928
56* Absent eyelashes (HP:0000561)1.42948406
57Multifactorial inheritance (HP:0001426)1.42279360
58Selective tooth agenesis (HP:0001592)1.39513764
59Abnormality of permanent molar morphology (HP:0011071)1.39103398
60Abnormality of the dental root (HP:0006486)1.39103398
61Taurodontia (HP:0000679)1.39103398
62Lip pit (HP:0100267)1.38917083
63Abnormality of the salivary glands (HP:0010286)1.35185065
64Craniofacial hyperostosis (HP:0004493)1.28805311
65Abnormality of molar morphology (HP:0011070)1.27059179
66Abnormality of molar (HP:0011077)1.27059179
67Ectropion (HP:0000656)1.26173091
68Nasolacrimal duct obstruction (HP:0000579)1.25290668
69Concave nail (HP:0001598)1.24370337
70Abnormality of the fingernails (HP:0001231)1.21620540
71Amelogenesis imperfecta (HP:0000705)1.20706329
72Abnormality of the dental pulp (HP:0006479)1.20106889
73Carious teeth (HP:0000670)1.18698475
74Bilateral sensorineural hearing impairment (HP:0008619)1.18333841
75Hyperhidrosis (HP:0000975)1.15878257
76Abnormality of placental membranes (HP:0011409)1.14261586
77Amniotic constriction ring (HP:0009775)1.14261586
78Skin ulcer (HP:0200042)1.11828578
79Neonatal onset (HP:0003623)1.11630103
80Dry skin (HP:0000958)1.10724189
81Aplasia involving bones of the upper limbs (HP:0009823)1.10313002
82Aplasia of the phalanges of the hand (HP:0009802)1.10313002
83Aplasia involving bones of the extremities (HP:0009825)1.10313002
84Cranial hyperostosis (HP:0004437)1.09139071
85Hypoplastic toenails (HP:0001800)1.07627732
86Generalized hyperpigmentation (HP:0007440)1.03951475
87Dehydration (HP:0001944)1.02482585
88Seborrheic dermatitis (HP:0001051)0.99296549
89Ventricular tachycardia (HP:0004756)0.99290337
90Abnormality of the frontal sinuses (HP:0002687)0.98958517
91Septate vagina (HP:0001153)0.98462503
92Anonychia (HP:0001798)0.97016663
93Laryngomalacia (HP:0001601)0.96561155
94Abnormality of the distal phalanges of the toes (HP:0010182)0.95662914
95Premature loss of primary teeth (HP:0006323)0.92251541
96Anhidrosis (HP:0000970)0.90356196
97Recurrent corneal erosions (HP:0000495)0.88370569
98Abnormality of the lacrimal duct (HP:0011481)0.86190538
99Xerostomia (HP:0000217)0.84331921
100Duplicated collecting system (HP:0000081)0.84001073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.25025389
2MAPKAPK34.31281515
3TESK23.71656843
4TXK3.33470583
5TESK13.05160967
6LMTK22.97470894
7MST1R2.68624268
8MATK2.63501276
9MAP4K22.56442541
10TGFBR12.33428681
11MAP3K62.30977062
12GRK62.30181494
13TAOK32.18772600
14LIMK12.06085154
15FER2.06059610
16SIK12.03042061
17MAP3K141.82733246
18EPHB21.75158635
19NME21.72246157
20BCKDK1.59936306
21TLK11.56630194
22MAP2K21.54853405
23EEF2K1.51214023
24EPHB11.47577852
25RPS6KB21.44796707
26ERN11.43798805
27MUSK1.41021994
28CDK121.29008186
29MAPKAPK21.24216337
30MAP3K121.21815718
31RIPK11.21448845
32EPHA31.21170173
33JAK11.20953946
34PTK21.20461293
35STK391.19495121
36IKBKB1.18107361
37IRAK31.14275974
38PTK61.08999973
39ARAF1.07066194
40PHKG11.05810551
41PHKG21.05810551
42MYLK1.05196987
43TBK11.00876024
44MET1.00432323
45LATS10.96622220
46KDR0.95466685
47SIK30.93651988
48PAK40.88902981
49BMPR20.84574777
50ILK0.82096415
51PIK3CG0.82067012
52VRK20.81322200
53TRIB30.78654872
54CDK60.73507885
55IKBKE0.72474813
56KIT0.68754319
57SMG10.67695348
58PRKD20.67042997
59NEK60.66882536
60MAP2K60.62807588
61MST40.62434950
62STK240.61491432
63PIM20.60584317
64NME10.59360067
65OXSR10.54257563
66PRKCI0.50571138
67MAPKAPK50.49850424
68TRPM70.49570578
69MAPK70.49017569
70IGF1R0.46653331
71MAP3K30.45829815
72MAPK120.45743867
73MAP2K10.45234509
74CDK30.44972807
75MAP3K90.41084516
76FES0.40709834
77STK380.39572752
78JAK30.38617871
79CSK0.37951495
80MAPK110.36929321
81LATS20.36463932
82BCR0.33158637
83IRAK10.32680911
84ABL20.32043151
85CDK40.31050442
86CDC42BPA0.31043249
87PRPF4B0.30087475
88FGFR30.27758935
89HCK0.25998527
90CHUK0.25013210
91INSRR0.24059116
92MAP3K20.24002566
93TTN0.23989198
94NEK10.21976274
95MAP4K10.21620328
96RPS6KA20.20748449
97ERBB20.20678186
98IRAK40.18515635
99SRPK10.18059551
100LRRK20.17962411

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000628.42923306
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010405.11620586
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.95456256
4Vitamin digestion and absorption_Homo sapiens_hsa049774.05753535
5Fatty acid biosynthesis_Homo sapiens_hsa000612.96041365
6Phototransduction_Homo sapiens_hsa047442.63191193
7Linoleic acid metabolism_Homo sapiens_hsa005912.56469936
8Fatty acid metabolism_Homo sapiens_hsa012122.51658833
9Phenylalanine metabolism_Homo sapiens_hsa003602.37021056
10Arachidonic acid metabolism_Homo sapiens_hsa005902.24538825
11Histidine metabolism_Homo sapiens_hsa003401.99441036
12Retinol metabolism_Homo sapiens_hsa008301.98739905
13Steroid biosynthesis_Homo sapiens_hsa001001.95104003
14Sphingolipid metabolism_Homo sapiens_hsa006001.70230258
15Ether lipid metabolism_Homo sapiens_hsa005651.59013208
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56260885
17beta-Alanine metabolism_Homo sapiens_hsa004101.54223510
18Glycerolipid metabolism_Homo sapiens_hsa005611.52777148
19PPAR signaling pathway_Homo sapiens_hsa033201.39078505
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.36087648
21Fat digestion and absorption_Homo sapiens_hsa049751.25089739
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12485920
23Fatty acid degradation_Homo sapiens_hsa000711.04726463
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01782051
25Sulfur metabolism_Homo sapiens_hsa009201.01553188
26Peroxisome_Homo sapiens_hsa041460.97374290
27GnRH signaling pathway_Homo sapiens_hsa049120.97244260
28Tyrosine metabolism_Homo sapiens_hsa003500.95392029
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94055058
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93529798
31Lysosome_Homo sapiens_hsa041420.91177417
32Salivary secretion_Homo sapiens_hsa049700.90381446
33Ovarian steroidogenesis_Homo sapiens_hsa049130.89305038
34Vascular smooth muscle contraction_Homo sapiens_hsa042700.88660253
35Nitrogen metabolism_Homo sapiens_hsa009100.86368514
36Collecting duct acid secretion_Homo sapiens_hsa049660.78230600
37Renin secretion_Homo sapiens_hsa049240.74149526
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.73099024
39Malaria_Homo sapiens_hsa051440.65632580
40Gastric acid secretion_Homo sapiens_hsa049710.63672364
41Pertussis_Homo sapiens_hsa051330.59293839
42ECM-receptor interaction_Homo sapiens_hsa045120.58496409
43Circadian rhythm_Homo sapiens_hsa047100.55270805
44Tryptophan metabolism_Homo sapiens_hsa003800.54642408
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54305428
46Pyruvate metabolism_Homo sapiens_hsa006200.54190958
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49394422
48Glioma_Homo sapiens_hsa052140.48953475
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45997407
50Melanogenesis_Homo sapiens_hsa049160.45635652
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44449517
52VEGF signaling pathway_Homo sapiens_hsa043700.43692093
53Sulfur relay system_Homo sapiens_hsa041220.41862014
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.39773929
55Vibrio cholerae infection_Homo sapiens_hsa051100.39759043
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39363331
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39319769
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38930233
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38900165
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38451399
61Long-term potentiation_Homo sapiens_hsa047200.34090141
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30961069
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.29727452
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29233315
65Mineral absorption_Homo sapiens_hsa049780.28351528
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27327189
67Chemical carcinogenesis_Homo sapiens_hsa052040.26441455
68Ras signaling pathway_Homo sapiens_hsa040140.25778434
69Amphetamine addiction_Homo sapiens_hsa050310.23896187
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23681664
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22936324
72Acute myeloid leukemia_Homo sapiens_hsa052210.21835877
73Carbon metabolism_Homo sapiens_hsa012000.21670346
74Butanoate metabolism_Homo sapiens_hsa006500.20761147
75Insulin signaling pathway_Homo sapiens_hsa049100.20177166
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20056307
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.19802751
78Glucagon signaling pathway_Homo sapiens_hsa049220.18739277
79Tuberculosis_Homo sapiens_hsa051520.18048827
80Arginine and proline metabolism_Homo sapiens_hsa003300.17515864
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15937438
82Metabolic pathways_Homo sapiens_hsa011000.14829208
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14123007
84Fructose and mannose metabolism_Homo sapiens_hsa000510.13301905
85Endocytosis_Homo sapiens_hsa041440.13121687
86Bladder cancer_Homo sapiens_hsa052190.12970543
87Estrogen signaling pathway_Homo sapiens_hsa049150.12739508
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.12496168
89Renin-angiotensin system_Homo sapiens_hsa046140.12402280
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12385635
91Notch signaling pathway_Homo sapiens_hsa043300.11850664
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.11380516
93Axon guidance_Homo sapiens_hsa043600.11034035
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11024670
95Olfactory transduction_Homo sapiens_hsa047400.10736211
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10481742
97ABC transporters_Homo sapiens_hsa020100.09889111
98Serotonergic synapse_Homo sapiens_hsa047260.09470544
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08170983
100Primary immunodeficiency_Homo sapiens_hsa053400.07789556

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