KRT86

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.90666241
2adhesion of symbiont to host cell (GO:0044650)9.90666241
3desmosome organization (GO:0002934)9.71293992
4citrulline biosynthetic process (GO:0019240)8.94029018
5hair follicle morphogenesis (GO:0031069)8.44265502
6adhesion of symbiont to host (GO:0044406)8.38651962
7peptide cross-linking (GO:0018149)8.33507756
8sleep (GO:0030431)8.16066445
9cellular response to interleukin-15 (GO:0071350)7.64082311
10regulation of memory T cell differentiation (GO:0043380)6.74252497
11negative regulation of cell killing (GO:0031342)6.71504477
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.71504477
13intermediate filament cytoskeleton organization (GO:0045104)6.65321864
14intermediate filament-based process (GO:0045103)6.43945313
15epidermis development (GO:0008544)6.13026043
16citrulline metabolic process (GO:0000052)5.92251441
17response to interleukin-15 (GO:0070672)5.90313616
18cell wall macromolecule catabolic process (GO:0016998)5.85982245
19cell wall macromolecule metabolic process (GO:0044036)5.85982245
20keratinocyte differentiation (GO:0030216)5.60416412
21cellular response to prostaglandin stimulus (GO:0071379)5.59037415
22establishment of skin barrier (GO:0061436)5.56078900
23hair cycle process (GO:0022405)5.37511482
24molting cycle process (GO:0022404)5.37511482
25bundle of His cell to Purkinje myocyte communication (GO:0086069)4.98874428
26macroautophagy (GO:0016236)4.98305324
27regulation of T cell mediated cytotoxicity (GO:0001914)4.96462009
28peptidyl-arginine modification (GO:0018195)4.92598339
29regulation of water loss via skin (GO:0033561)4.92136627
30hemidesmosome assembly (GO:0031581)4.83684632
31lymph node development (GO:0048535)4.81148554
32adenosine metabolic process (GO:0046085)4.78811155
33regulation of defense response to virus by host (GO:0050691)4.76842351
34skin morphogenesis (GO:0043589)4.67668844
35response to muramyl dipeptide (GO:0032495)4.61356920
36tolerance induction (GO:0002507)4.54973171
37positive regulation of osteoclast differentiation (GO:0045672)4.40436040
38positive regulation of T cell mediated cytotoxicity (GO:0001916)4.37874989
39epidermal cell differentiation (GO:0009913)4.36125758
40regulation of germinal center formation (GO:0002634)4.35808982
41positive regulation of defense response to virus by host (GO:0002230)4.27985464
42tumor necrosis factor-mediated signaling pathway (GO:0033209)4.27131516
43natural killer cell activation involved in immune response (GO:0002323)4.19726603
44male sex determination (GO:0030238)4.17927206
45regulation of leukocyte mediated cytotoxicity (GO:0001910)4.17155436
46regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.10812919
47positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.04454179
48molting cycle (GO:0042303)35.6645126
49hair cycle (GO:0042633)35.6645126
50regulation of activation of Janus kinase activity (GO:0010533)3.88521553
51negative regulation of interleukin-10 production (GO:0032693)3.87573518
52natural killer cell activation (GO:0030101)3.80520045
53tooth mineralization (GO:0034505)3.72865861
54positive regulation of interleukin-17 production (GO:0032740)3.66021284
55regulation of cell killing (GO:0031341)3.64707959
56positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.64388408
57keratinocyte development (GO:0003334)3.63763818
58negative regulation of T cell mediated immunity (GO:0002710)3.61542957
59negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.57487621
60negative regulation of NF-kappaB import into nucleus (GO:0042347)3.56139619
61regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.49264676
62phosphatidylinositol acyl-chain remodeling (GO:0036149)3.46272936
63negative regulation of glycogen biosynthetic process (GO:0045719)3.37187268
64negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.36221818
65multicellular organismal water homeostasis (GO:0050891)3.32324022
66positive regulation of T cell mediated immunity (GO:0002711)3.32236487
67positive regulation of T-helper 1 type immune response (GO:0002827)3.31573892
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.31377705
69positive regulation of Rho protein signal transduction (GO:0035025)3.31135621
70positive regulation of T cell cytokine production (GO:0002726)3.26510107
71regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.24953272
72negative regulation of keratinocyte proliferation (GO:0010839)3.24613905
73positive regulation of cell fate commitment (GO:0010455)3.22331071
74T-helper cell differentiation (GO:0042093)3.20879017
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20879017
76negative regulation of DNA-templated transcription, elongation (GO:0032785)3.20180030
77interferon-gamma production (GO:0032609)3.19445837
78regulation of T cell mediated immunity (GO:0002709)3.18764753
79trivalent inorganic anion homeostasis (GO:0072506)3.18164032
80phosphate ion homeostasis (GO:0055062)3.18164032
81regulation of keratinocyte differentiation (GO:0045616)3.17386363
82phosphatidylserine acyl-chain remodeling (GO:0036150)3.16571783
83positive regulation of hair follicle development (GO:0051798)3.16052389
84positive regulation of hair cycle (GO:0042635)3.16052389
85chaperone mediated protein folding requiring cofactor (GO:0051085)3.15218850
86positive regulation of cholesterol efflux (GO:0010875)3.14622162
87negative regulation of lipid storage (GO:0010888)3.11632214
88negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.10830100
89hair follicle development (GO:0001942)3.10048477
90regulation of T-helper 1 type immune response (GO:0002825)3.09649780
91regulation of natural killer cell mediated immunity (GO:0002715)3.09309935
92regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09309935
93response to prostaglandin (GO:0034694)3.00881249
94positive regulation of heat generation (GO:0031652)2.99495206
95regulation of natural killer cell activation (GO:0032814)2.99172639
96positive regulation of prostaglandin secretion (GO:0032308)2.98855524
97regulation of hair follicle development (GO:0051797)2.98350690
98regulation of hippo signaling (GO:0035330)2.95587034
99germ cell migration (GO:0008354)2.95161713
100positive regulation of cholesterol transport (GO:0032376)2.93595366
101positive regulation of sterol transport (GO:0032373)2.93595366
102phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.93052160
103positive regulation of T-helper cell differentiation (GO:0045624)2.90053994
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89995885
105positive regulation of cell killing (GO:0031343)2.89918018
106regulation of B cell receptor signaling pathway (GO:0050855)2.89425644
107mammary gland alveolus development (GO:0060749)2.89283106
108epithelium development (GO:0060429)2.88324726
109positive regulation of T cell differentiation in thymus (GO:0033089)2.88234996
110protein deneddylation (GO:0000338)2.85905824
111regulation of gamma-delta T cell differentiation (GO:0045586)2.85886992
112mammary gland epithelial cell proliferation (GO:0033598)2.85248037
113response to misfolded protein (GO:0051788)2.84907732
114cytoplasmic sequestering of transcription factor (GO:0042994)2.81030377
115negative regulation of lymphocyte mediated immunity (GO:0002707)2.77476353
116negative regulation of glycogen metabolic process (GO:0070874)2.76964019
117polyketide metabolic process (GO:0030638)2.74773668
118doxorubicin metabolic process (GO:0044598)2.74773668
119daunorubicin metabolic process (GO:0044597)2.74773668
120base-excision repair, AP site formation (GO:0006285)2.73639571
121water homeostasis (GO:0030104)2.72584107
122bone trabecula formation (GO:0060346)2.72508881
123negative regulation of innate immune response (GO:0045824)2.71841327
124alpha-beta T cell differentiation involved in immune response (GO:0002293)2.71690419
125alpha-beta T cell activation involved in immune response (GO:0002287)2.71690419
126T cell differentiation involved in immune response (GO:0002292)2.71690419
127positive regulation of epidermis development (GO:0045684)2.66546004
128gap junction assembly (GO:0016264)2.64951823
129ectoderm development (GO:0007398)2.61829724
130negative regulation of protein localization to plasma membrane (GO:1903077)2.56315839
131regulation of hair cycle (GO:0042634)2.56224261
132positive regulation of meiotic cell cycle (GO:0051446)2.55921170
133atrioventricular valve morphogenesis (GO:0003181)2.55172187
134regulation of epidermal cell differentiation (GO:0045604)2.47595040
135regulation of epidermis development (GO:0045682)2.41895225
136fatty acid elongation (GO:0030497)2.41297168
137phosphatidylserine metabolic process (GO:0006658)2.37933323
138ventricular cardiac muscle cell action potential (GO:0086005)2.32023939
139phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.29565951
140epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.26405621
141negative regulation of cell fate specification (GO:0009996)2.23939483
142positive regulation of epidermal cell differentiation (GO:0045606)2.16207471
143wound healing, spreading of epidermal cells (GO:0035313)2.14765035
144regulation of mesenchymal cell apoptotic process (GO:2001053)2.12097483
145skin development (GO:0043588)2.12048793
146lymph vessel development (GO:0001945)2.11427844
147aging (GO:0007568)2.10696707
148cell surface receptor signaling pathway involved in heart development (GO:0061311)2.08518999
149phosphatidylcholine acyl-chain remodeling (GO:0036151)2.04340316
150positive regulation of monocyte chemotaxis (GO:0090026)2.01530870
151regulation of cardioblast differentiation (GO:0051890)2.00800360
152intermediate filament organization (GO:0045109)12.2637890
153keratinization (GO:0031424)11.3040907
154cytoskeletal anchoring at plasma membrane (GO:0007016)1.99210585
155cranial suture morphogenesis (GO:0060363)1.95857026
156epithelial cell-cell adhesion (GO:0090136)1.93434586
157myotube differentiation (GO:0014902)1.92445961
158regulation of heart rate by cardiac conduction (GO:0086091)1.91107618
159regulation of ruffle assembly (GO:1900027)1.90202374
160outflow tract septum morphogenesis (GO:0003148)1.90200306
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.88248985
162antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.88248985
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.87819190
164negative regulation of epidermis development (GO:0045683)1.86050187
165cell communication involved in cardiac conduction (GO:0086065)1.84443959
166regulation of keratinocyte proliferation (GO:0010837)1.81961438
167planar cell polarity pathway involved in neural tube closure (GO:0090179)1.81064203
168cell-substrate junction assembly (GO:0007044)1.80460756
169ephrin receptor signaling pathway (GO:0048013)1.76034604
170alditol phosphate metabolic process (GO:0052646)1.75862623
171non-canonical Wnt signaling pathway (GO:0035567)1.67680757
172regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.66027742
173very long-chain fatty acid metabolic process (GO:0000038)1.64314697
174primary alcohol catabolic process (GO:0034310)1.62241762
175coronary vasculature morphogenesis (GO:0060977)1.61359754
176regulation of cardioblast proliferation (GO:0003264)1.60014513
177regulation of secondary heart field cardioblast proliferation (GO:0003266)1.60014513
178regulation of transforming growth factor beta2 production (GO:0032909)1.58588638
179antigen processing and presentation of endogenous antigen (GO:0019883)1.57694424
180keratinocyte proliferation (GO:0043616)1.56567508
181cellular modified amino acid biosynthetic process (GO:0042398)1.55755926
182wound healing, spreading of cells (GO:0044319)1.51822270
183negative regulation of cell fate commitment (GO:0010454)1.51796404
184phosphatidylglycerol metabolic process (GO:0046471)1.49525849
185regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.49427932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.48277113
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.85806850
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.57457112
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.12295252
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.89639897
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85827991
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72927742
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56963948
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53279436
10GATA1_22025678_ChIP-Seq_K562_Human2.45714461
11RUNX_20019798_ChIP-Seq_JUKART_Human2.45138764
12* CTCF_20526341_ChIP-Seq_ESCs_Human2.25863035
13NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.20309243
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07529892
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06102536
16TP63_17297297_ChIP-ChIP_HaCaT_Human12.4371592
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94313026
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.91632293
19* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.86449061
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.79593143
21CSB_26484114_Chip-Seq_FIBROBLAST_Human1.78198653
22P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.77994804
23EGR1_19032775_ChIP-ChIP_M12_Human1.76256284
24* E2F1_20622854_ChIP-Seq_HELA_Human1.75692667
25* TAF2_19829295_ChIP-Seq_ESCs_Human1.71309446
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70244668
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66295747
28CTCF_27219007_Chip-Seq_Bcells_Human1.65897567
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65278887
30ERG_20517297_ChIP-Seq_VCAP_Human1.62931082
31P53_21459846_ChIP-Seq_SAOS-2_Human1.61848298
32SCL_19346495_ChIP-Seq_HPC-7_Human1.61321617
33* NANOG_20526341_ChIP-Seq_ESCs_Human1.60036607
34LXR_22292898_ChIP-Seq_THP-1_Human1.58545278
35RACK7_27058665_Chip-Seq_MCF-7_Human1.56516858
36TP63_22573176_ChIP-Seq_HFKS_Human1.54053507
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.53850990
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51741345
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.50919238
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50908895
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50821875
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50821875
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49084718
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45775050
45MYB_26560356_Chip-Seq_TH2_Human1.42692311
46ATF3_27146783_Chip-Seq_COLON_Human1.41960788
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40920243
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.40790334
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40522866
50* BCL6_27268052_Chip-Seq_Bcells_Human1.40079394
51* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.39952620
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39373103
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37964752
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.37613215
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37461584
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35778620
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34083056
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32366147
59* BCOR_27268052_Chip-Seq_Bcells_Human1.32134559
60UTX_26944678_Chip-Seq_JUKART_Human1.31941067
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30264842
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29606189
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.28349675
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25767698
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.25414275
66STAT1_20625510_ChIP-Seq_HELA_Human1.23705430
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22023820
68* YY1_22570637_ChIP-Seq_MALME-3M_Human1.21838896
69AHR_22903824_ChIP-Seq_MCF-7_Human1.21424918
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.20175125
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19344542
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19287204
73MAF_26560356_Chip-Seq_TH1_Human1.18930808
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18557250
75E2F1_17053090_ChIP-ChIP_MCF-7_Human1.18480115
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17934168
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17043569
78CEBPB_22108803_ChIP-Seq_LS180_Human1.16830752
79SA1_27219007_Chip-Seq_Bcells_Human1.15906040
80SMC4_20622854_ChIP-Seq_HELA_Human1.15252978
81MAF_26560356_Chip-Seq_TH2_Human1.14730158
82* PHF8_20622854_ChIP-Seq_HELA_Human1.14627194
83ETS1_21867929_ChIP-Seq_TH2_Mouse1.13708289
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.13612318
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13599476
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.13590727
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12491025
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12413262
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11887130
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11850968
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.11541690
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.10916018
93TCF7_22412390_ChIP-Seq_EML_Mouse1.10779668
94GATA3_24758297_ChIP-Seq_MCF-7_Human1.09625113
95GATA3_27048872_Chip-Seq_THYMUS_Human1.09608588
96* P68_20966046_ChIP-Seq_HELA_Human1.09275618
97IRF1_19129219_ChIP-ChIP_H3396_Human1.09179901
98* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08819916
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08182816
100* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08053641
101UBF1/2_26484160_Chip-Seq_HMECs_Human1.07476753
102SPI1_20517297_ChIP-Seq_HL60_Human1.07334544
103GATA3_26560356_Chip-Seq_TH2_Human1.07286935
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07277084
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06938892
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06028207
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05674733
108TP63_23658742_ChIP-Seq_EP156T_Human1.05531742
109SOX2_21211035_ChIP-Seq_LN229_Human1.05521478
110RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05402003
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05270851
112GATA4_25053715_ChIP-Seq_YYC3_Human1.04822481
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.04801094
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04720759
115PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01906706
116HOXB7_26014856_ChIP-Seq_BT474_Human1.01571203
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01379262
118ELF5_23300383_ChIP-Seq_T47D_Human1.01279692
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01140303
120* RAC3_21632823_ChIP-Seq_H3396_Human1.00946090
121* P300_27268052_Chip-Seq_Bcells_Human0.99568473
122GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99258061
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98538658
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98499840
125KLF5_25053715_ChIP-Seq_YYC3_Human0.97489692
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.96260973
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95704988
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93541167
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93069223
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91776351
131KDM2B_26808549_Chip-Seq_DND41_Human0.90825853
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89699517
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89116516
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.88912421
135GATA6_21074721_ChIP-Seq_CACO-2_Human0.88881872
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88836040
137ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88332043
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87572273
139TP53_18474530_ChIP-ChIP_U2OS_Human0.87208181
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.86806916
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.86768667
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86381975
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84783068
144RXR_22108803_ChIP-Seq_LS180_Human0.84224652
145SOX2_20726797_ChIP-Seq_SW620_Human0.83504134
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83190115
147GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82150082
148* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81115058
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80796100
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.79740595
151* FOXH1_21741376_ChIP-Seq_ESCs_Human0.79093627
152RNF2_27304074_Chip-Seq_ESCs_Mouse0.77756342
153EZH2_27294783_Chip-Seq_ESCs_Mouse0.77441144
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77438930
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76710349
156SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74507666
157GATA3_21867929_ChIP-Seq_TH1_Mouse0.72120262
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.71892902
159ZNF263_19887448_ChIP-Seq_K562_Human0.71317965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.70454761
2MP0002098_abnormal_vibrissa_morphology7.34792662
3MP0000647_abnormal_sebaceous_gland6.50569348
4MP0002796_impaired_skin_barrier5.80859657
5MP0010234_abnormal_vibrissa_follicle5.17247840
6MP0005275_abnormal_skin_tensile5.06109904
7MP0003878_abnormal_ear_physiology5.01844791
8MP0005377_hearing/vestibular/ear_phenot5.01844791
9MP0000383_abnormal_hair_follicle4.45195519
10MP0000377_abnormal_hair_follicle4.13976436
11MP0010678_abnormal_skin_adnexa3.94791466
12MP0005671_abnormal_response_to3.90635230
13MP0003705_abnormal_hypodermis_morpholog3.74333257
14MP0005501_abnormal_skin_physiology3.63106551
15MP0000427_abnormal_hair_cycle3.46632517
16MP0002254_reproductive_system_inflammat2.94089452
17MP0003724_increased_susceptibility_to2.74539385
18MP0004381_abnormal_hair_follicle2.71925125
19MP0001216_abnormal_epidermal_layer2.63057348
20MP0000367_abnormal_coat/_hair2.42033288
21MP0004947_skin_inflammation2.29906090
22MP0010771_integument_phenotype2.25677680
23MP0003453_abnormal_keratinocyte_physiol2.22017246
24MP0003195_calcinosis2.18079588
25MP0000685_abnormal_immune_system2.17877638
26MP0003879_abnormal_hair_cell2.13886868
27MP0002060_abnormal_skin_morphology2.13812559
28MP0001243_abnormal_dermal_layer2.13057077
29MP0002234_abnormal_pharynx_morphology2.09673515
30MP0002933_joint_inflammation1.90344317
31MP0000467_abnormal_esophagus_morphology1.76014233
32MP0005000_abnormal_immune_tolerance1.73003257
33MP0002876_abnormal_thyroid_physiology1.57257557
34MP0001188_hyperpigmentation1.56264446
35MP0009053_abnormal_anal_canal1.51985930
36MP0009931_abnormal_skin_appearance1.49776910
37MP0000762_abnormal_tongue_morphology1.49358080
38MP0003566_abnormal_cell_adhesion1.47758605
39MP0001835_abnormal_antigen_presentation1.46602603
40MP0008872_abnormal_physiological_respon1.44742744
41MP0002723_abnormal_immune_serum1.44336255
42MP0003436_decreased_susceptibility_to1.41149992
43MP0001533_abnormal_skeleton_physiology1.37155768
44MP0005409_darkened_coat_color1.36673563
45MP0008875_abnormal_xenobiotic_pharmacok1.35683990
46MP0005083_abnormal_biliary_tract1.33880195
47MP0001819_abnormal_immune_cell1.28958825
48MP0009785_altered_susceptibility_to1.27983566
49MP0002405_respiratory_system_inflammati1.24950805
50MP0002420_abnormal_adaptive_immunity1.22366663
51MP0002998_abnormal_bone_remodeling1.21234847
52MP0004043_abnormal_pH_regulation1.15717934
53MP0003941_abnormal_skin_development1.15002299
54MP0001800_abnormal_humoral_immune1.14115969
55MP0002452_abnormal_antigen_presenting1.13134348
56MP0001765_abnormal_ion_homeostasis1.08756716
57MP0001501_abnormal_sleep_pattern1.07195879
58MP0002148_abnormal_hypersensitivity_rea1.06374800
59MP0003828_pulmonary_edema1.03106848
60MP0005025_abnormal_response_to1.02461030
61MP0003866_abnormal_defecation1.02417215
62MP0000703_abnormal_thymus_morphology1.00845987
63MP0002722_abnormal_immune_system1.00278479
64MP0002419_abnormal_innate_immunity0.99925312
65MP0010155_abnormal_intestine_physiology0.99675464
66MP0000716_abnormal_immune_system0.96572067
67MP0001191_abnormal_skin_condition0.95876379
68MP0002102_abnormal_ear_morphology0.94627477
69MP0001485_abnormal_pinna_reflex0.93585353
70MP0001790_abnormal_immune_system0.91845393
71MP0005387_immune_system_phenotype0.91845393
72MP0005174_abnormal_tail_pigmentation0.90341027
73MP0004885_abnormal_endolymph0.90026735
74MP0004147_increased_porphyrin_level0.89220751
75MP0001881_abnormal_mammary_gland0.88233729
76MP0002095_abnormal_skin_pigmentation0.85840538
77MP0006072_abnormal_retinal_apoptosis0.84624769
78MP0004185_abnormal_adipocyte_glucose0.79877326
79MP0005390_skeleton_phenotype0.79803293
80MP0001851_eye_inflammation0.79466152
81MP0002398_abnormal_bone_marrow0.79187853
82MP0004264_abnormal_extraembryonic_tissu0.79087290
83MP0002009_preneoplasia0.79019552
84MP0008438_abnormal_cutaneous_collagen0.78709274
85MP0001873_stomach_inflammation0.78192824
86MP0005365_abnormal_bile_salt0.76185312
87MP0001853_heart_inflammation0.72852836
88MP0001845_abnormal_inflammatory_respons0.72792140
89MP0000003_abnormal_adipose_tissue0.72268349
90MP0002429_abnormal_blood_cell0.72045985
91MP0009780_abnormal_chondrocyte_physiolo0.72021840
92MP0003656_abnormal_erythrocyte_physiolo0.71313042
93MP0003795_abnormal_bone_structure0.70155053
94MP0000689_abnormal_spleen_morphology0.69856392
95MP0003315_abnormal_perineum_morphology0.66625436
96MP0000858_altered_metastatic_potential0.66379805
97MP0001905_abnormal_dopamine_level0.65691885
98MP0001849_ear_inflammation0.64979629
99MP0002877_abnormal_melanocyte_morpholog0.64615330
100MP0008877_abnormal_DNA_methylation0.63931495
101MP0003191_abnormal_cellular_cholesterol0.62930854
102MP0001340_abnormal_eyelid_morphology0.62304586
103MP0010030_abnormal_orbit_morphology0.60134019
104MP0001346_abnormal_lacrimal_gland0.58151227
105MP0001661_extended_life_span0.56126359
106MP0000627_abnormal_mammary_gland0.56118009
107MP0002282_abnormal_trachea_morphology0.55307635
108MP0005023_abnormal_wound_healing0.50650108
109MP0005075_abnormal_melanosome_morpholog0.49594089
110MP0000566_synostosis0.49106632
111MP0005451_abnormal_body_composition0.48098821
112MP0003755_abnormal_palate_morphology0.47773101
113MP0002970_abnormal_white_adipose0.46986762
114MP0001784_abnormal_fluid_regulation0.42409224
115MP0002249_abnormal_larynx_morphology0.42005524
116MP0009840_abnormal_foam_cell0.38703605
117MP0002111_abnormal_tail_morphology0.38578392
118MP0000678_abnormal_parathyroid_gland0.37009163
119MP0004272_abnormal_basement_membrane0.34224353
120MP0010352_gastrointestinal_tract_polyps0.32582789
121MP0002177_abnormal_outer_ear0.29824508
122MP0003329_amyloid_beta_deposits0.28835942
123MP0009379_abnormal_foot_pigmentation0.28770836
124MP0000465_gastrointestinal_hemorrhage0.27180858
125MP0003385_abnormal_body_wall0.26539304
126MP0003763_abnormal_thymus_physiology0.25154640
127MP0002697_abnormal_eye_size0.23942500
128MP0001958_emphysema0.22969166
129MP0000537_abnormal_urethra_morphology0.22113687
130MP0004510_myositis0.21578999
131MP0003950_abnormal_plasma_membrane0.21441134
132MP0003300_gastrointestinal_ulcer0.19860079
133MP0005248_abnormal_Harderian_gland0.19550922
134MP0004019_abnormal_vitamin_homeostasis0.19442417
135MP0006054_spinal_hemorrhage0.18936052
136MP0003448_altered_tumor_morphology0.18176257
137MP0002166_altered_tumor_susceptibility0.17937837
138MP0004742_abnormal_vestibular_system0.17166556
139MP0002006_tumorigenesis0.17106602
140MP0003638_abnormal_response/metabolism_0.16997640
141MP0004858_abnormal_nervous_system0.16584177
142MP0000604_amyloidosis0.14577000
143MP0000432_abnormal_head_morphology0.14459749
144MP0001879_abnormal_lymphatic_vessel0.14249416
145MP0003075_altered_response_to0.13215791
146MP0003935_abnormal_craniofacial_develop0.12840557
147MP0003045_fibrosis0.10722655
148MP0003011_delayed_dark_adaptation0.09719270
149MP0005193_abnormal_anterior_eye0.09458728
150MP0005666_abnormal_adipose_tissue0.09355873
151MP0005375_adipose_tissue_phenotype0.09181570
152MP0000516_abnormal_urinary_system0.08400451
153MP0005367_renal/urinary_system_phenotyp0.08400451
154MP0005165_increased_susceptibility_to0.08012388
155MP0000462_abnormal_digestive_system0.07915316
156MP0005076_abnormal_cell_differentiation0.07518174
157MP0002233_abnormal_nose_morphology0.07485004
158MP0008569_lethality_at_weaning0.06755598
159MP0001348_abnormal_lacrimal_gland0.05258570
160MP0005330_cardiomyopathy0.05144331
161MP0000013_abnormal_adipose_tissue0.05125394

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.58739702
2* Brittle hair (HP:0002299)8.70908988
3* Nail dystrophy (HP:0008404)6.75313225
4Abnormality of nail color (HP:0100643)6.63263030
5Abnormal hair laboratory examination (HP:0003328)6.06522533
6Fragile nails (HP:0001808)5.86546956
7Alopecia of scalp (HP:0002293)5.33089875
8Severe combined immunodeficiency (HP:0004430)5.23047721
9Palmoplantar hyperkeratosis (HP:0000972)5.14036989
10Onycholysis (HP:0001806)5.08130039
11Thick nail (HP:0001805)5.01160234
12Increased IgE level (HP:0003212)4.87066052
13Palmar hyperkeratosis (HP:0010765)4.83507591
14* Fine hair (HP:0002213)4.76463929
15Plantar hyperkeratosis (HP:0007556)4.67692488
16Follicular hyperkeratosis (HP:0007502)4.60413559
17Right ventricular cardiomyopathy (HP:0011663)4.35713927
18Conical tooth (HP:0000698)4.30299547
19Anhidrosis (HP:0000970)4.10290459
20Combined immunodeficiency (HP:0005387)4.02294398
21Optic neuritis (HP:0100653)3.92357765
22Retrobulbar optic neuritis (HP:0100654)3.92357765
23Absent eyebrow (HP:0002223)3.87065190
24Erythema (HP:0010783)3.76071615
25Sparse eyelashes (HP:0000653)3.68054931
26Orchitis (HP:0100796)3.51763421
27Milia (HP:0001056)3.51468271
28Oral leukoplakia (HP:0002745)3.51162361
29IgG deficiency (HP:0004315)3.29341419
30Amelogenesis imperfecta (HP:0000705)3.26930134
31Abnormality of eosinophils (HP:0001879)3.23630437
32T lymphocytopenia (HP:0005403)3.21639923
33Abnormality of the frontal sinuses (HP:0002687)3.21147932
34Persistence of primary teeth (HP:0006335)3.15532223
35Renal cortical cysts (HP:0000803)3.03371944
36Myositis (HP:0100614)3.00951609
37Erythroderma (HP:0001019)3.00915728
38Thyroiditis (HP:0100646)2.98020849
39Ridged nail (HP:0001807)2.96378849
40Parakeratosis (HP:0001036)2.89089716
41Premature loss of primary teeth (HP:0006323)2.83815521
42Curly hair (HP:0002212)2.82832044
43Intention tremor (HP:0002080)2.78870851
44Bulbar palsy (HP:0001283)2.74700141
45Abnormality of T cell number (HP:0011839)2.70042894
46Congenital ichthyosiform erythroderma (HP:0007431)2.69045841
47Congenital, generalized hypertrichosis (HP:0004540)2.68380853
48Abnormal blistering of the skin (HP:0008066)2.62976196
49Torticollis (HP:0000473)2.59635827
50Natal tooth (HP:0000695)2.58854574
51Increased density of long bones (HP:0006392)2.56552120
52Gastrointestinal infarctions (HP:0005244)2.55218075
53Pigmentary retinal degeneration (HP:0001146)2.54007550
54Neck muscle weakness (HP:0000467)2.53359348
55Anorexia (HP:0002039)2.49883207
56Aplasia cutis congenita (HP:0001057)2.48388443
57Absent hair (HP:0002298)2.47164207
58Dry hair (HP:0011359)2.46722025
59Bilateral sensorineural hearing impairment (HP:0008619)2.46297421
60Advanced eruption of teeth (HP:0006288)2.45613244
61Tongue fasciculations (HP:0001308)2.38070584
62Depressed nasal tip (HP:0000437)2.34604204
63Muscle fibrillation (HP:0010546)2.32369116
64Vascular calcification (HP:0004934)2.22592110
65Hypophosphatemia (HP:0002148)2.20930310
66Craniofacial dystonia (HP:0012179)2.20224332
67Corneal erosion (HP:0200020)2.19904963
68Hypohidrosis (HP:0000966)2.19327741
69Gastrointestinal stroma tumor (HP:0100723)2.17314517
70Vertigo (HP:0002321)2.14735797
71Palmoplantar keratoderma (HP:0000982)2.12188352
72Clumsiness (HP:0002312)2.10625820
73Arterial thrombosis (HP:0004420)2.10394755
74Recurrent bronchitis (HP:0002837)2.09156308
75Abnormality of the umbilical cord (HP:0010881)2.09024526
76Ventricular tachycardia (HP:0004756)2.07846162
77Aplasia/hypoplasia of the uterus (HP:0008684)2.07284044
78Stridor (HP:0010307)2.02983571
79Focal dystonia (HP:0004373)2.01465828
80Hypoplasia of the thymus (HP:0000778)2.01438876
81* Hypotrichosis (HP:0001006)13.7038755
82Woolly hair (HP:0002224)11.6780459
83* Slow-growing hair (HP:0002217)10.1590424
84* Abnormality of hair growth rate (HP:0011363)10.1590424
85Pulmonary infiltrates (HP:0002113)1.99561464
86Pruritus (HP:0000989)1.98893516
87Abnormality of T cells (HP:0002843)1.98861247
88Abnormality of the pupil (HP:0000615)1.98828242
89Difficulty walking (HP:0002355)1.98174967
90Granulocytopenia (HP:0001913)1.95378950
91Bronchitis (HP:0012387)1.93756843
92Stomach cancer (HP:0012126)1.90689373
93Hypoplasia of the uterus (HP:0000013)1.89308320
94Abnormality of the distal phalanges of the toes (HP:0010182)1.88933783
95Ventricular fibrillation (HP:0001663)1.87997488
96Alveolar cell carcinoma (HP:0006519)1.87842651
97Abnormality of the neuromuscular junction (HP:0003398)1.86730985
98Fatigable weakness (HP:0003473)1.86730985
99Abnormality of the parietal bone (HP:0002696)1.85616904
100Concave nail (HP:0001598)1.85127830
101Cardiovascular calcification (HP:0011915)1.84653421
102Pancreatitis (HP:0001733)1.81690134
103Hemoptysis (HP:0002105)1.80035462
104Abnormality of dental color (HP:0011073)1.78225732
105Stillbirth (HP:0003826)1.78078005
106Easy fatigability (HP:0003388)1.77604642
107Abnormality of permanent molar morphology (HP:0011071)1.77446337
108Abnormality of the dental root (HP:0006486)1.77446337
109Taurodontia (HP:0000679)1.77446337
110Abnormality of molar (HP:0011077)1.75408820
111Abnormality of molar morphology (HP:0011070)1.75408820
112Abnormality of the proximal phalanges of the hand (HP:0009834)1.75360830
113B lymphocytopenia (HP:0010976)1.73859824
114Abnormality of glycolipid metabolism (HP:0010969)1.73174964
115Abnormality of liposaccharide metabolism (HP:0010968)1.73174964
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.73174964
117Chronic bronchitis (HP:0004469)1.71357622
118Widely patent fontanelles and sutures (HP:0004492)1.71034580
119Abnormality of the renal cortex (HP:0011035)1.69474119
120Vasculitis (HP:0002633)1.69364581
121Abnormality of the aortic arch (HP:0012303)1.68937210
122Absent eyelashes (HP:0000561)1.68452947
123Pustule (HP:0200039)1.66742525
124Poor head control (HP:0002421)1.64887579
125Asplenia (HP:0001746)1.64209955
126Unilateral renal agenesis (HP:0000122)1.63881851
127Hydroxyprolinuria (HP:0003080)1.63660983
128Abnormality of proline metabolism (HP:0010907)1.63660983
129Blepharitis (HP:0000498)1.61782718
130Nonimmune hydrops fetalis (HP:0001790)1.61532158
131Recurrent corneal erosions (HP:0000495)1.60643287
132Conjunctival hamartoma (HP:0100780)1.58225714
133Hyporeflexia of lower limbs (HP:0002600)1.55356880
134Sudden death (HP:0001699)1.55040616
135Abnormality of the dental pulp (HP:0006479)1.54559064
136Acanthosis nigricans (HP:0000956)1.52817972
137Hypergammaglobulinemia (HP:0010702)1.49515202
138Abnormality of placental membranes (HP:0011409)1.48020512
139Amniotic constriction ring (HP:0009775)1.48020512
140Carious teeth (HP:0000670)1.46850336
141Anonychia (HP:0001798)1.45851802
142Gangrene (HP:0100758)1.45144620
143Keratoconjunctivitis sicca (HP:0001097)1.43610942
144Achilles tendon contracture (HP:0001771)1.40510297
145Ectropion (HP:0000656)1.40243150
146Neonatal onset (HP:0003623)1.40200117
147Selective tooth agenesis (HP:0001592)1.38613419
148Lip pit (HP:0100267)1.38146150
149Craniofacial hyperostosis (HP:0004493)1.34812645
150Abnormality of the fingernails (HP:0001231)1.34594780
151Laryngomalacia (HP:0001601)1.33314810
152Abnormality of the Achilles tendon (HP:0005109)1.32606161
153Distal lower limb muscle weakness (HP:0009053)1.32545451
154Autoamputation (HP:0001218)1.32048521
155Atrophic scars (HP:0001075)1.28840615
156Sparse scalp hair (HP:0002209)1.27736219
157Widely spaced teeth (HP:0000687)1.26539216
158Keratoconjunctivitis (HP:0001096)1.26071601
159Lack of skin elasticity (HP:0100679)1.25204093
160Hyperhidrosis (HP:0000975)1.20519029
161Epidermoid cyst (HP:0200040)1.19847508
162Bronchomalacia (HP:0002780)1.18291078
163Abnormality of the gastric mucosa (HP:0004295)1.17991777
164Increased connective tissue (HP:0009025)1.17861538
165* Heterogeneous (HP:0001425)1.17310021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK6.42211604
2TXK5.45003508
3TAOK34.51300792
4EPHA24.36618128
5MAP3K144.18319168
6FER4.10912440
7ERN14.05277607
8MAP3K64.01774872
9MAPKAPK33.85907814
10TAOK13.23437259
11EPHB22.92334590
12MAP3K32.87871570
13TRIB32.84780057
14TBK12.78517645
15IKBKE2.46268676
16MAP3K112.31498333
17MAP3K22.24166827
18MAP4K22.19687005
19EPHB12.17555025
20TESK22.06576054
21LATS12.05951407
22IKBKB2.04515401
23SIK32.03996822
24RPS6KB21.97927479
25KDR1.90157406
26EEF2K1.87264550
27TLK11.81308548
28MAP2K61.67262079
29BMPR21.59164783
30TTN1.56162992
31LATS21.55903981
32STK391.55154190
33NEK61.50091149
34LIMK11.44039027
35PIK3CG1.42595262
36FGFR41.41049847
37IRAK31.36506615
38BMX1.35609716
39PKN21.34448364
40NME11.30281076
41MAP3K11.29356858
42MAP2K31.28231338
43BLK1.20155400
44EIF2AK21.19684471
45RIPK11.16692058
46CDK61.16407449
47FGFR11.11386446
48MAPKAPK21.09567366
49KSR21.09401049
50PDGFRA1.08281152
51BCKDK1.08202511
52BCR1.08144219
53KIT1.06994902
54PTK61.06142638
55LRRK21.04151856
56FGFR31.02478765
57FGFR21.02399923
58CHUK0.97973833
59MST1R0.97046866
60RPS6KA40.96190827
61MAP3K90.94927422
62MARK30.93579144
63SIK10.92819902
64MAP3K70.89720141
65PTK20.87828861
66PAK40.87748411
67SIK20.87631645
68PIM20.85216097
69ZAK0.85161575
70DDR20.77736218
71SRPK10.77434881
72CDK40.76978356
73WNK40.74972600
74DYRK1B0.73772513
75PIK3CA0.72527678
76STK380.71974210
77LCK0.71957762
78CSK0.71746499
79MAP2K10.71695212
80MAP2K40.70600561
81MAP3K100.69271771
82EPHA30.66869544
83PRKD10.66699738
84MAPK70.66578017
85TESK10.65966119
86MST40.65503124
87GRK10.62951365
88PAK30.62826788
89ZAP700.62299954
90PRKCH0.60500972
91CDK190.59597883
92PBK0.58066310
93JAK10.57261476
94IGF1R0.57057760
95OXSR10.56411662
96MET0.56353325
97TRPM70.56336974
98TYRO30.55562977
99NUAK10.55221714
100CDK30.55188471
101ALK0.52415911
102MAP3K50.51022503
103RPS6KA10.50821616
104JAK30.50393709
105PAK60.50246583
106TYK20.49757219
107PAK20.49268512
108PRKCI0.48525490
109MAP3K80.47197216
110GSK3A0.45801942
111STK38L0.44762655
112RET0.44475710
113VRK20.44095298
114ERBB40.43894694
115MAPK150.43570332
116GRK60.43319568
117NTRK20.43088874
118RPS6KA20.42949710
119TGFBR20.42335032
120MAP4K10.42099620
121CDC42BPA0.41123775
122PHKG20.39730227
123PHKG10.39730227
124ICK0.39545189
125ERBB20.39454257
126TAOK20.38777196
127JAK20.38473237
128MAPK120.38350501
129STK110.38332025
130LYN0.38057748
131TGFBR10.37636191
132PRKCQ0.37309982
133INSR0.35649703
134CLK10.35031326
135PINK10.34931162
136MAPK30.34507746
137MATK0.34502490
138CSNK1E0.34171898
139MAP2K20.33571191
140HCK0.32649140
141FYN0.31453414
142ADRBK20.31153535
143MAPK110.31131626
144ILK0.30521764
145ABL10.30226355
146CASK0.29728073
147LMTK20.28862191
148NEK10.27259050
149PDPK10.26594269
150MYLK0.26045719
151PRKACG0.26032403
152CSNK1A10.24972939
153FES0.24651347
154ARAF0.24621700
155SRC0.24585960
156ERBB30.24189740
157PRKCD0.19824553
158CSF1R0.19355653
159MAPK40.18601135
160MAP3K120.18504904
161IRAK20.17888640
162BTK0.17858274
163CDK70.16885105
164STK100.16110985
165EGFR0.15301403
166PIM10.13271617
167RPS6KA60.13170337

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.15517272
2Linoleic acid metabolism_Homo sapiens_hsa005915.09540547
3Fat digestion and absorption_Homo sapiens_hsa049753.40152795
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.06412693
5Primary immunodeficiency_Homo sapiens_hsa053402.72862073
6Ether lipid metabolism_Homo sapiens_hsa005652.68837380
7Fatty acid elongation_Homo sapiens_hsa000622.65189203
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.37078232
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.22721365
10Basal cell carcinoma_Homo sapiens_hsa052172.06545958
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01778415
12Arachidonic acid metabolism_Homo sapiens_hsa005901.99901918
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93097835
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83624037
15Phenylalanine metabolism_Homo sapiens_hsa003601.80976972
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79504798
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.79096349
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77795132
19VEGF signaling pathway_Homo sapiens_hsa043701.67599448
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66281160
21Sulfur metabolism_Homo sapiens_hsa009201.62317312
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58936743
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58836588
24Vitamin digestion and absorption_Homo sapiens_hsa049771.51456268
25Nitrogen metabolism_Homo sapiens_hsa009101.51285842
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47506911
27Melanogenesis_Homo sapiens_hsa049161.46821128
28Axon guidance_Homo sapiens_hsa043601.45243347
29Caffeine metabolism_Homo sapiens_hsa002321.43344149
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42492831
31Histidine metabolism_Homo sapiens_hsa003401.39249469
32Tryptophan metabolism_Homo sapiens_hsa003801.38197641
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35156139
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31974945
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.29380977
36Bladder cancer_Homo sapiens_hsa052191.28735579
37Hedgehog signaling pathway_Homo sapiens_hsa043401.26877812
38Glioma_Homo sapiens_hsa052141.24516784
39TNF signaling pathway_Homo sapiens_hsa046681.23819118
40Proteoglycans in cancer_Homo sapiens_hsa052051.23352428
41Acute myeloid leukemia_Homo sapiens_hsa052211.23343550
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.19084462
43Sphingolipid metabolism_Homo sapiens_hsa006001.18733172
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18185490
45Thyroid cancer_Homo sapiens_hsa052161.17207101
46Malaria_Homo sapiens_hsa051441.16808842
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16267192
48GnRH signaling pathway_Homo sapiens_hsa049121.15403571
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.14574209
50Pancreatic secretion_Homo sapiens_hsa049721.14189882
51Hippo signaling pathway_Homo sapiens_hsa043901.13142234
52Peroxisome_Homo sapiens_hsa041461.10808335
53T cell receptor signaling pathway_Homo sapiens_hsa046601.10520790
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.09220607
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07972223
56Tight junction_Homo sapiens_hsa045301.05127509
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04311751
58Circadian rhythm_Homo sapiens_hsa047101.02343003
59Long-term potentiation_Homo sapiens_hsa047201.00101233
60PPAR signaling pathway_Homo sapiens_hsa033200.99906867
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.99465555
62ABC transporters_Homo sapiens_hsa020100.97966534
63ECM-receptor interaction_Homo sapiens_hsa045120.97032660
64Dorso-ventral axis formation_Homo sapiens_hsa043200.96898781
65Mineral absorption_Homo sapiens_hsa049780.95761090
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95463200
67Shigellosis_Homo sapiens_hsa051310.95241356
68Lysosome_Homo sapiens_hsa041420.93544555
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93523953
70Fructose and mannose metabolism_Homo sapiens_hsa000510.93325025
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.92485238
72Retinol metabolism_Homo sapiens_hsa008300.92347949
73Adherens junction_Homo sapiens_hsa045200.90277860
74Steroid biosynthesis_Homo sapiens_hsa001000.90047352
75Tyrosine metabolism_Homo sapiens_hsa003500.86267755
76Pertussis_Homo sapiens_hsa051330.84445001
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.82442286
78Ras signaling pathway_Homo sapiens_hsa040140.81653543
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80747463
80beta-Alanine metabolism_Homo sapiens_hsa004100.80262677
81Estrogen signaling pathway_Homo sapiens_hsa049150.79538099
82Non-small cell lung cancer_Homo sapiens_hsa052230.78110240
83Endometrial cancer_Homo sapiens_hsa052130.77413856
84Amoebiasis_Homo sapiens_hsa051460.76617456
85Staphylococcus aureus infection_Homo sapiens_hsa051500.74874759
86Long-term depression_Homo sapiens_hsa047300.74729363
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74428787
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73608830
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72659705
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.71290766
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.69481202
92Apoptosis_Homo sapiens_hsa042100.68852270
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68236538
94Measles_Homo sapiens_hsa051620.67928409
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67390539
96Wnt signaling pathway_Homo sapiens_hsa043100.66074587
97N-Glycan biosynthesis_Homo sapiens_hsa005100.65040320
98Gastric acid secretion_Homo sapiens_hsa049710.61946390
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.60868112
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60797302
101Fatty acid biosynthesis_Homo sapiens_hsa000610.60110670
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.58829790
103Fatty acid metabolism_Homo sapiens_hsa012120.58585315
104Insulin resistance_Homo sapiens_hsa049310.58375632
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58210391
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.58057418
107Renin secretion_Homo sapiens_hsa049240.57956169
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57668621
109Hepatitis C_Homo sapiens_hsa051600.57121581
110MicroRNAs in cancer_Homo sapiens_hsa052060.56110231
111Legionellosis_Homo sapiens_hsa051340.55641166
112Osteoclast differentiation_Homo sapiens_hsa043800.55287400
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54954909
114Rap1 signaling pathway_Homo sapiens_hsa040150.54616102
115Herpes simplex infection_Homo sapiens_hsa051680.54343540
116Salmonella infection_Homo sapiens_hsa051320.52952103
117Gap junction_Homo sapiens_hsa045400.52328410
118Platelet activation_Homo sapiens_hsa046110.51747089
119Glycerolipid metabolism_Homo sapiens_hsa005610.51658475
120Starch and sucrose metabolism_Homo sapiens_hsa005000.51352293
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51108449
122Protein digestion and absorption_Homo sapiens_hsa049740.50598753
123Salivary secretion_Homo sapiens_hsa049700.49910022
124Selenocompound metabolism_Homo sapiens_hsa004500.49826167
125Focal adhesion_Homo sapiens_hsa045100.49709762
126Phototransduction_Homo sapiens_hsa047440.49642735
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48002532
128Butanoate metabolism_Homo sapiens_hsa006500.45641691
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44772138
130Base excision repair_Homo sapiens_hsa034100.44709649
131Arginine biosynthesis_Homo sapiens_hsa002200.44554123
132ErbB signaling pathway_Homo sapiens_hsa040120.44000289
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.43593527
134Fatty acid degradation_Homo sapiens_hsa000710.43451548
135Rheumatoid arthritis_Homo sapiens_hsa053230.43252829
136Notch signaling pathway_Homo sapiens_hsa043300.42918524
137Renal cell carcinoma_Homo sapiens_hsa052110.42713056
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42322229
139Hematopoietic cell lineage_Homo sapiens_hsa046400.41512218
140Oxytocin signaling pathway_Homo sapiens_hsa049210.41389074
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41102531
142Chronic myeloid leukemia_Homo sapiens_hsa052200.41027475
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39946688
144Toxoplasmosis_Homo sapiens_hsa051450.39762973
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38131590
146Chemical carcinogenesis_Homo sapiens_hsa052040.37877783
147B cell receptor signaling pathway_Homo sapiens_hsa046620.37332342
148Prion diseases_Homo sapiens_hsa050200.37317641
149Olfactory transduction_Homo sapiens_hsa047400.37275784
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.37254764
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36754435
152Tuberculosis_Homo sapiens_hsa051520.36635974
153Leishmaniasis_Homo sapiens_hsa051400.35280244
154Prolactin signaling pathway_Homo sapiens_hsa049170.35154012
155Other glycan degradation_Homo sapiens_hsa005110.34773381
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34710930
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34379876
158Ovarian steroidogenesis_Homo sapiens_hsa049130.32773346
159Small cell lung cancer_Homo sapiens_hsa052220.32369664
160Insulin signaling pathway_Homo sapiens_hsa049100.32225313
161Endocytosis_Homo sapiens_hsa041440.31631070
162Dilated cardiomyopathy_Homo sapiens_hsa054140.30699784
163TGF-beta signaling pathway_Homo sapiens_hsa043500.30503632
164Galactose metabolism_Homo sapiens_hsa000520.30114043
165Viral carcinogenesis_Homo sapiens_hsa052030.28203175
166Sulfur relay system_Homo sapiens_hsa041220.27160180
167Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22872056
168Cysteine and methionine metabolism_Homo sapiens_hsa002700.21640270
169Propanoate metabolism_Homo sapiens_hsa006400.20636676
170Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16916952

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