ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hemidesmosome assembly (GO:0031581)	7.94597481
2	GDP-mannose metabolic process (GO:0019673)	7.45088632
3	desmosome organization (GO:0002934)	7.01587369
4	negative regulation of cell aging (GO:0090344)	6.30471180
5	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	5.76382745
6	protein carboxylation (GO:0018214)	5.24182416
7	peptidyl-glutamic acid carboxylation (GO:0017187)	5.24182416
8	nucleotide-sugar biosynthetic process (GO:0009226)	5.19501252
9	cellular response to ATP (GO:0071318)	5.12448949
10	DNA strand renaturation (GO:0000733)	5.06096656
11	mitotic cell cycle arrest (GO:0071850)	5.01414549
12	polyketide metabolic process (GO:0030638)	4.91514674
13	doxorubicin metabolic process (GO:0044598)	4.91514674
14	daunorubicin metabolic process (GO:0044597)	4.91514674
15	regulation of skeletal muscle contraction (GO:0014819)	4.82383493
16	type B pancreatic cell proliferation (GO:0044342)	4.75637160
17	positive regulation of keratinocyte differentiation (GO:0045618)	4.69688549
18	lens fiber cell differentiation (GO:0070306)	4.61794491
19	semaphorin-plexin signaling pathway (GO:0071526)	4.39510427
20	cell-substrate junction assembly (GO:0007044)	4.38230144
21	aminoglycoside antibiotic metabolic process (GO:0030647)	4.36203655
22	positive regulation of epidermal cell differentiation (GO:0045606)	4.34081974
23	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.24154284
24	cellular response to vitamin D (GO:0071305)	4.14275847
25	adenosine receptor signaling pathway (GO:0001973)	4.11780431
26	meiotic chromosome segregation (GO:0045132)	4.05674509
27	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.05047526
28	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.98652452
29	protein retention in ER lumen (GO:0006621)	3.98428282
30	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.81340148
31	sphingosine metabolic process (GO:0006670)	3.77243917
32	activation of Rac GTPase activity (GO:0032863)	3.72651256
33	adenine nucleotide transport (GO:0051503)	3.71316579
34	proline biosynthetic process (GO:0006561)	3.63420792
35	regulation of translational fidelity (GO:0006450)	3.62482769
36	positive regulation of epidermis development (GO:0045684)	3.61208844
37	transepithelial transport (GO:0070633)	3.55788054
38	purine ribonucleotide transport (GO:0015868)	3.53799249
39	regulation of cell aging (GO:0090342)	3.50741488
40	regulation of synapse structural plasticity (GO:0051823)	3.46511297
41	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.46227359
42	diol metabolic process (GO:0034311)	3.45639822
43	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.43588151
44	cell-substrate adherens junction assembly (GO:0007045)	3.43050939
45	focal adhesion assembly (GO:0048041)	3.43050939
46	regulation of water loss via skin (GO:0033561)	3.38885023
47	estrogen biosynthetic process (GO:0006703)	3.36291754
48	response to gravity (GO:0009629)	3.32911296
49	rRNA methylation (GO:0031167)	3.31591160
50	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	3.28815124
51	establishment of skin barrier (GO:0061436)	3.27137428
52	negative regulation of keratinocyte proliferation (GO:0010839)	3.26198125
53	COPI coating of Golgi vesicle (GO:0048205)	3.25291772
54	Golgi transport vesicle coating (GO:0048200)	3.25291772
55	keratinocyte development (GO:0003334)	3.24207163
56	protein hydroxylation (GO:0018126)	3.22392056
57	sphingomyelin metabolic process (GO:0006684)	3.22211573
58	UV protection (GO:0009650)	3.21101575
59	actin filament bundle organization (GO:0061572)	3.21050786
60	actin filament bundle assembly (GO:0051017)	3.21050786
61	folic acid metabolic process (GO:0046655)	3.18214050
62	phosphate ion transmembrane transport (GO:0035435)	3.16616371
63	regulation of phospholipid biosynthetic process (GO:0071071)	3.14276824
64	rRNA modification (GO:0000154)	3.08981127
65	cell adhesion mediated by integrin (GO:0033627)	3.05719771
66	cellular response to vitamin (GO:0071295)	3.03423907
67	cyclooxygenase pathway (GO:0019371)	3.01833392
68	endocytic recycling (GO:0032456)	3.00287179
69	cellular response to virus (GO:0098586)	2.99639388
70	mammary gland epithelial cell proliferation (GO:0033598)	2.97193227
71	sensory perception of taste (GO:0050909)	2.97139865
72	membrane raft organization (GO:0031579)	2.91771541
73	sphingoid metabolic process (GO:0046519)	2.91531944
74	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.88249275
75	epithelial cell-cell adhesion (GO:0090136)	2.86979026
76	atrioventricular valve morphogenesis (GO:0003181)	2.86073536
77	regulation of hippo signaling (GO:0035330)	2.85721351
78	peptidyl-proline hydroxylation (GO:0019511)	2.85661847
79	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.80669092
80	purinergic receptor signaling pathway (GO:0035587)	2.76663873
81	protein localization to endosome (GO:0036010)	2.76525274
82	morphogenesis of embryonic epithelium (GO:0016331)	2.76205301
83	adherens junction assembly (GO:0034333)	2.76109723
84	negative regulation of interleukin-8 production (GO:0032717)	2.75657272
85	nuclear envelope reassembly (GO:0031468)	2.75039418
86	mitotic nuclear envelope reassembly (GO:0007084)	2.75039418
87	purine nucleotide transport (GO:0015865)	2.74484302
88	positive regulation of pseudopodium assembly (GO:0031274)	2.74318044
89	regulation of keratinocyte differentiation (GO:0045616)	2.73885222
90	regulation of vitamin metabolic process (GO:0030656)	2.73818939
91	surfactant homeostasis (GO:0043129)	2.73350319
92	endothelial cell chemotaxis (GO:0035767)	2.71637876
93	nucleotide transmembrane transport (GO:1901679)	2.66994932
94	response to ATP (GO:0033198)	2.66064920
95	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.63272517
96	regulation of epidermal growth factor-activated receptor activity (GO:0007176)	2.62130005
97	activation of NF-kappaB-inducing kinase activity (GO:0007250)	2.58225089
98	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.56607888
99	primary alcohol catabolic process (GO:0034310)	2.56344987
100	positive regulation of heat generation (GO:0031652)	2.55382542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.76275252
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.46249454
3	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.28537841
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.89672866
5	VDR_21846776_ChIP-Seq_THP-1_Human	2.84049117
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.66526033
7	RACK7_27058665_Chip-Seq_MCF-7_Human	2.55168204
8	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.46497438
9	LXR_22292898_ChIP-Seq_THP-1_Human	2.45093176
10	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.35658415
11	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.34603086
12	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.28753396
13	P68_20966046_ChIP-Seq_HELA_Human	2.17699531
14	ATF3_27146783_Chip-Seq_COLON_Human	2.15815247
15	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.01865125
16	XRN2_22483619_ChIP-Seq_HELA_Human	1.98226960
17	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.88903474
18	TP53_22127205_ChIP-Seq_IMR90_Human	1.85156400
19	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.78986564
20	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.78986564
21	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.76255532
22	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.76179172
23	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.69404581
24	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.65782033
25	E2F1_20622854_ChIP-Seq_HELA_Human	1.64630406
26	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.63526612
27	BCOR_27268052_Chip-Seq_Bcells_Human	1.63404336
28	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.63299657
29	ZNF263_19887448_ChIP-Seq_K562_Human	1.63223533
30	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.61679389
31	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.61182789
32	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.58150106
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.57254508
34	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.56452355
35	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.55716266
36	MAF_26560356_Chip-Seq_TH2_Human	1.55460470
37	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.51867561
38	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.48924489
39	SMC4_20622854_ChIP-Seq_HELA_Human	1.48545210
40	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.47957489
41	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.46123074
42	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.45442675
43	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.45317792
44	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.45247266
45	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.45147427
46	BCL6_27268052_Chip-Seq_Bcells_Human	1.44346412
47	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.41916733
48	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.40595833
49	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.39457577
50	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.39418649
51	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.38811249
52	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.37414104
53	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.37369882
54	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.36827866
55	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.35955371
56	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.35207237
57	MAF_26560356_Chip-Seq_TH1_Human	1.34718687
58	MYC_22102868_ChIP-Seq_BL_Human	1.31887727
59	CTCF_27219007_Chip-Seq_Bcells_Human	1.30663374
60	PHF8_20622854_ChIP-Seq_HELA_Human	1.30601866
61	CREB1_26743006_Chip-Seq_LNCaP_Human	1.28449021
62	VDR_24763502_ChIP-Seq_THP-1_Human	1.28044348
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.27421921
64	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.27157447
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.27016067
66	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25334871
67	CTCF_21964334_Chip-Seq_Bcells_Human	1.24773075
68	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.24322640
69	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.22142108
70	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.21880176
71	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.21434698
72	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.20353658
73	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.19802844
74	KDM2B_26808549_Chip-Seq_DND41_Human	1.18471881
75	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.18221165
76	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.18216081
77	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.18060933
78	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17646050
79	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.15854791
80	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14638172
81	TCF7_22412390_ChIP-Seq_EML_Mouse	1.12017022
82	TP63_22573176_ChIP-Seq_HFKS_Human	1.11033850
83	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.10865605
84	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.10735275
85	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10009804
86	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08120669
87	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.06962175
88	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06831322
89	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.06261348
90	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.05954989
91	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.04802137
92	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01943357
93	GATA6_25053715_ChIP-Seq_YYC3_Human	1.00749603
94	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.98089601
95	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.97492797
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.96026594
97	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.95885001
98	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.95883416
99	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.95505811
100	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.95337149

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	4.20153823
2	MP0010234_abnormal_vibrissa_follicle	3.47488351
3	MP0005174_abnormal_tail_pigmentation	3.35322872
4	MP0003705_abnormal_hypodermis_morpholog	3.21976795
5	MP0003453_abnormal_keratinocyte_physiol	3.18204780
6	MP0000579_abnormal_nail_morphology	3.01542656
7	MP0001986_abnormal_taste_sensitivity	2.90251701
8	MP0003566_abnormal_cell_adhesion	2.89538202
9	MP0005083_abnormal_biliary_tract	2.81656753
10	MP0005501_abnormal_skin_physiology	2.78274404
11	MP0008875_abnormal_xenobiotic_pharmacok	2.76615116
12	MP0005423_abnormal_somatic_nervous	2.73121206
13	MP0001661_extended_life_span	2.53351920
14	MP0002796_impaired_skin_barrier	2.45486868
15	MP0005409_darkened_coat_color	2.45373754
16	MP0002060_abnormal_skin_morphology	2.36198837
17	MP0000751_myopathy	2.35006960
18	MP0005023_abnormal_wound_healing	2.25625265
19	MP0005330_cardiomyopathy	2.24320681
20	MP0003806_abnormal_nucleotide_metabolis	2.19652891
21	MP0001216_abnormal_epidermal_layer	2.14845437
22	MP0000013_abnormal_adipose_tissue	2.14372025
23	MP0000750_abnormal_muscle_regeneration	1.90205530
24	MP0004782_abnormal_surfactant_physiolog	1.89836080
25	MP0003091_abnormal_cell_migration	1.85913249
26	MP0000762_abnormal_tongue_morphology	1.85364920
27	MP0003941_abnormal_skin_development	1.78996436
28	MP0010771_integument_phenotype	1.74096541
29	MP0005076_abnormal_cell_differentiation	1.73121819
30	MP0000467_abnormal_esophagus_morphology	1.70899136
31	MP0005257_abnormal_intraocular_pressure	1.68478725
32	MP0004381_abnormal_hair_follicle	1.61967724
33	MP0000003_abnormal_adipose_tissue	1.57955660
34	MP0009053_abnormal_anal_canal	1.52840122
35	MP0003136_yellow_coat_color	1.49370503
36	MP0001756_abnormal_urination	1.42042378
37	MP0000537_abnormal_urethra_morphology	1.41107147
38	MP0003191_abnormal_cellular_cholesterol	1.36421318
39	MP0001348_abnormal_lacrimal_gland	1.35985023
40	MP0000858_altered_metastatic_potential	1.35331103
41	MP0005248_abnormal_Harderian_gland	1.33235650
42	MP0000377_abnormal_hair_follicle	1.31085261
43	MP0010678_abnormal_skin_adnexa	1.30870501
44	MP0002098_abnormal_vibrissa_morphology	1.26301037
45	MP0001873_stomach_inflammation	1.25639601
46	MP0001849_ear_inflammation	1.24216584
47	MP0009931_abnormal_skin_appearance	1.18091853
48	MP0009840_abnormal_foam_cell	1.18071730
49	MP0004947_skin_inflammation	1.16640745
50	MP0003950_abnormal_plasma_membrane	1.15614695
51	MP0002877_abnormal_melanocyte_morpholog	1.15382259
52	MP0001502_abnormal_circadian_rhythm	1.15122950
53	MP0000538_abnormal_urinary_bladder	1.14756743
54	MP0004957_abnormal_blastocyst_morpholog	1.13983100
55	MP0005410_abnormal_fertilization	1.13494180
56	MP0002160_abnormal_reproductive_system	1.12387593
57	MP0009780_abnormal_chondrocyte_physiolo	1.12239660
58	MP0000367_abnormal_coat/_hair	1.10579599
59	MP0001765_abnormal_ion_homeostasis	1.09897552
60	MP0004185_abnormal_adipocyte_glucose	1.04471316
61	MP0005375_adipose_tissue_phenotype	1.03367281
62	MP0000566_synostosis	1.01846476
63	MP0000358_abnormal_cell_content/	1.00255597
64	MP0002139_abnormal_hepatobiliary_system	0.99564350
65	MP0005360_urolithiasis	0.97820750
66	MP0002234_abnormal_pharynx_morphology	0.96185923
67	MP0003111_abnormal_nucleus_morphology	0.94902470
68	MP0001188_hyperpigmentation	0.94488314
69	MP0001919_abnormal_reproductive_system	0.91571830
70	MP0000383_abnormal_hair_follicle	0.90862583
71	MP0001191_abnormal_skin_condition	0.90838832
72	MP0004019_abnormal_vitamin_homeostasis	0.90690679
73	MP0003315_abnormal_perineum_morphology	0.89657050
74	MP0000470_abnormal_stomach_morphology	0.89506324
75	MP0000627_abnormal_mammary_gland	0.88289258
76	MP0009643_abnormal_urine_homeostasis	0.88281776
77	MP0005666_abnormal_adipose_tissue	0.88194109
78	MP0003448_altered_tumor_morphology	0.87308922
79	MP0000490_abnormal_crypts_of	0.84382763
80	MP0005584_abnormal_enzyme/coenzyme_acti	0.83264600
81	MP0000427_abnormal_hair_cycle	0.81905444
82	MP0005451_abnormal_body_composition	0.80010230
83	MP0005332_abnormal_amino_acid	0.79844077
84	MP0001243_abnormal_dermal_layer	0.79130293
85	MP0003077_abnormal_cell_cycle	0.78067926
86	MP0010030_abnormal_orbit_morphology	0.77817196
87	MP0004233_abnormal_muscle_weight	0.77280041
88	MP0001881_abnormal_mammary_gland	0.77076380
89	MP0002332_abnormal_exercise_endurance	0.76083397
90	MP0000747_muscle_weakness	0.74555717
91	MP0000015_abnormal_ear_pigmentation	0.72795810
92	MP0004272_abnormal_basement_membrane	0.71759836
93	MP0001340_abnormal_eyelid_morphology	0.68139758
94	MP0001958_emphysema	0.68062952
95	MP0002136_abnormal_kidney_physiology	0.66525990
96	MP0004197_abnormal_fetal_growth/weight/	0.66127641
97	MP0003656_abnormal_erythrocyte_physiolo	0.65526227
98	MP0002086_abnormal_extraembryonic_tissu	0.64925628
99	MP0005621_abnormal_cell_physiology	0.64618114
100	MP0000678_abnormal_parathyroid_gland	0.63729665

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	5.91118087
2	Popliteal pterygium (HP:0009756)	5.46261900
3	Poikiloderma (HP:0001029)	5.30929363
4	Ulnar bowing (HP:0003031)	4.69438723
5	Rib fusion (HP:0000902)	4.42096497
6	Thin bony cortex (HP:0002753)	4.39567075
7	Dyschromatopsia (HP:0007641)	4.04257043
8	Hypotrichosis (HP:0001006)	3.98643132
9	Abnormality of the intrinsic pathway (HP:0010989)	3.98336253
10	Nail dystrophy (HP:0008404)	3.89930615
11	Pterygium (HP:0001059)	3.78247400
12	Onycholysis (HP:0001806)	3.72753628
13	Amniotic constriction ring (HP:0009775)	3.66594296
14	Abnormality of placental membranes (HP:0011409)	3.66594296
15	Mesangial abnormality (HP:0001966)	3.63870837
16	Milia (HP:0001056)	3.45732375
17	Akinesia (HP:0002304)	3.42200484
18	Choroideremia (HP:0001139)	3.40756369
19	Attenuation of retinal blood vessels (HP:0007843)	3.37182900
20	Annular pancreas (HP:0001734)	3.33690749
21	Facial hemangioma (HP:0000329)	3.30016473
22	Increased hepatocellular lipid droplets (HP:0006565)	3.25690551
23	Atrioventricular block (HP:0001678)	3.25642830
24	Renal Fanconi syndrome (HP:0001994)	3.24890840
25	Brittle hair (HP:0002299)	3.24147117
26	Hemorrhage of the eye (HP:0011885)	3.21265549
27	Prolonged partial thromboplastin time (HP:0003645)	3.21240373
28	Short chin (HP:0000331)	3.21209582
29	Facial diplegia (HP:0001349)	3.18964832
30	Squamous cell carcinoma (HP:0002860)	3.17614633
31	Abnormal albumin level (HP:0012116)	3.15321172
32	Hypoalbuminemia (HP:0003073)	3.15321172
33	Coronal craniosynostosis (HP:0004440)	3.11289958
34	Turricephaly (HP:0000262)	3.09523851
35	Aplasia of the musculature (HP:0100854)	3.06998084
36	Lipid accumulation in hepatocytes (HP:0006561)	3.05800249
37	Atrophic scars (HP:0001075)	3.04613390
38	Bowed forearm bones (HP:0003956)	3.00591203
39	Bowing of the arm (HP:0006488)	3.00591203
40	Joint hemorrhage (HP:0005261)	2.97207953
41	Pili torti (HP:0003777)	2.96092302
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.93739855
43	Cheilitis (HP:0100825)	2.88180705
44	Rectal fistula (HP:0100590)	2.81467633
45	Rectovaginal fistula (HP:0000143)	2.81467633
46	Vaginal fistula (HP:0004320)	2.80463336
47	Abnormality of nail color (HP:0100643)	2.78172983
48	Plantar hyperkeratosis (HP:0007556)	2.74508803
49	Fetal akinesia sequence (HP:0001989)	2.70383132
50	Intestinal fistula (HP:0100819)	2.63001389
51	Delayed epiphyseal ossification (HP:0002663)	2.62604409
52	Chorioretinal atrophy (HP:0000533)	2.59597451
53	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.59233259
54	Cervical subluxation (HP:0003308)	2.56737761
55	Neonatal respiratory distress (HP:0002643)	2.53466470
56	Zonular cataract (HP:0010920)	2.45515246
57	Broad face (HP:0000283)	2.40759915
58	Abnormality of the neuromuscular junction (HP:0003398)	2.35291522
59	Fatigable weakness (HP:0003473)	2.35291522
60	Anteriorly placed anus (HP:0001545)	2.35047751
61	Abnormality of the costochondral junction (HP:0000919)	2.32322806
62	Fragile nails (HP:0001808)	2.29989763
63	Neonatal onset (HP:0003623)	2.29133111
64	Joint stiffness (HP:0001387)	2.28763825
65	Diminished movement (HP:0002374)	2.26610709
66	Lip pit (HP:0100267)	2.25000050
67	Tibial bowing (HP:0002982)	2.24205773
68	Increased intramyocellular lipid droplets (HP:0012240)	2.21034400
69	Enlarged epiphyses (HP:0010580)	2.20692008
70	Decreased central vision (HP:0007663)	2.19304378
71	Short humerus (HP:0005792)	2.18912132
72	Abnormal atrioventricular conduction (HP:0005150)	2.18101761
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15447433
74	Vertebral clefting (HP:0008428)	2.13389868
75	Increased muscle lipid content (HP:0009058)	2.12665115
76	Right ventricular cardiomyopathy (HP:0011663)	2.12396811
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08393315
78	Abnormal hair laboratory examination (HP:0003328)	2.07576832
79	Hypophosphatemic rickets (HP:0004912)	2.07498279
80	Capillary hemangiomas (HP:0005306)	2.06114338
81	Fused cervical vertebrae (HP:0002949)	2.05390209
82	Bony spicule pigmentary retinopathy (HP:0007737)	2.01851108
83	Aplasia/hypoplasia of the humerus (HP:0006507)	2.01544925
84	Palmoplantar hyperkeratosis (HP:0000972)	2.01470575
85	Ridged nail (HP:0001807)	1.99337145
86	Absent thumb (HP:0009777)	1.95790823
87	Abnormality of renal resorption (HP:0011038)	1.95373265
88	Widely patent fontanelles and sutures (HP:0004492)	1.92674581
89	Myotonia (HP:0002486)	1.92284585
90	Heart block (HP:0012722)	1.91556230
91	Abnormality of the common coagulation pathway (HP:0010990)	1.90536654
92	Bifid uvula (HP:0000193)	1.89939287
93	Patellar aplasia (HP:0006443)	1.88810450
94	Hypoplasia of dental enamel (HP:0006297)	1.87819883
95	Fragile skin (HP:0001030)	1.87440973
96	Thick nail (HP:0001805)	1.87144169
97	Flat occiput (HP:0005469)	1.86901496
98	Hypoplasia of the uterus (HP:0000013)	1.86679773
99	Congenital stationary night blindness (HP:0007642)	1.84620178
100	Aplasia/Hypoplasia of the patella (HP:0006498)	1.84343152

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.85759252
2	MAPK15	4.99556882
3	MST1R	4.71229625
4	MET	3.33519274
5	ARAF	2.96583076
6	LMTK2	2.95249182
7	NME2	2.84817402
8	TESK2	2.81119544
9	MAP3K9	2.32477918
10	ERN1	2.31068579
11	TRIB3	2.28462125
12	IRAK3	2.28066356
13	MUSK	2.20810204
14	TESK1	1.91829372
15	PTK2	1.83059470
16	SIK1	1.75875798
17	EPHB1	1.69253928
18	FLT3	1.62919982
19	PIM2	1.58472537
20	PAK4	1.57801657
21	NTRK1	1.52446814
22	TTN	1.48207656
23	WNK4	1.47847075
24	EPHB2	1.44144318
25	SIK3	1.37873132
26	LIMK1	1.21034137
27	BMX	1.08538055
28	MAP3K13	1.07777807
29	LATS2	1.07587743
30	PHKG2	1.04376422
31	PHKG1	1.04376422
32	PDGFRA	0.99655368
33	MAPKAPK3	0.98336315
34	TGFBR2	0.90638044
35	TBK1	0.88205770
36	STK16	0.88203661
37	TLK1	0.82595163
38	ERBB4	0.81797213
39	MOS	0.81789711
40	MAP3K3	0.80476652
41	PRKD2	0.80305638
42	SMG1	0.79818375
43	LATS1	0.79291356
44	BUB1	0.75625105
45	STK10	0.74648699
46	ICK	0.73624703
47	RAF1	0.70897726
48	MAP3K12	0.70787341
49	STK38	0.70459649
50	ADRBK1	0.69517932
51	PBK	0.67931020
52	PRKCI	0.67570396
53	MAP3K14	0.66770359
54	PKN2	0.66053373
55	PDPK1	0.65916307
56	ILK	0.65688014
57	IRAK2	0.64659481
58	MAPK11	0.64051826
59	TRIM28	0.61563359
60	NEK1	0.60773660
61	AURKA	0.60689725
62	ABL2	0.59844145
63	EIF2AK1	0.59173003
64	RIPK1	0.58979985
65	GRK6	0.58078720
66	BRAF	0.57336711
67	ZAP70	0.56990528
68	CDK12	0.56651092
69	MTOR	0.54058218
70	RPS6KA2	0.52146142
71	PAK1	0.51446827
72	PTK6	0.50172446
73	CCNB1	0.49895921
74	KSR1	0.43314092
75	IKBKB	0.43204683
76	CDK6	0.41156355
77	CDK18	0.40534432
78	SIK2	0.40258922
79	MAP2K2	0.39603304
80	TRPM7	0.39215763
81	CDK15	0.38453479
82	CDC42BPA	0.37527998
83	MAPKAPK2	0.36813287
84	CDK8	0.35925311
85	MAP2K1	0.34755487
86	CHUK	0.33570169
87	CDK11A	0.33117925
88	MELK	0.32807370
89	BLK	0.31217164
90	RPS6KB2	0.29992825
91	VRK2	0.29349899
92	MAP3K8	0.28932024
93	PRKD1	0.26526726
94	MATK	0.26526157
95	PDGFRB	0.26494739
96	CDK4	0.25780638
97	PTK2B	0.25381183
98	MST4	0.25284616
99	KSR2	0.23936277
100	NEK2	0.23840988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	5.70039445
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	5.03551857
3	Sulfur relay system_Homo sapiens_hsa04122	4.14999186
4	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.35193465
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.19753600
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.50424713
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.41850427
8	Galactose metabolism_Homo sapiens_hsa00052	1.97411718
9	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.94473017
10	Sphingolipid metabolism_Homo sapiens_hsa00600	1.92418351
11	Circadian rhythm_Homo sapiens_hsa04710	1.83657593
12	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.60463674
13	Bladder cancer_Homo sapiens_hsa05219	1.57427231
14	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.55567979
15	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.35522442
16	Hippo signaling pathway_Homo sapiens_hsa04390	1.33199164
17	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.33081126
18	Small cell lung cancer_Homo sapiens_hsa05222	1.31366979
19	ECM-receptor interaction_Homo sapiens_hsa04512	1.28361092
20	Sulfur metabolism_Homo sapiens_hsa00920	1.26197490
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22252811
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.21856321
23	Glutathione metabolism_Homo sapiens_hsa00480	1.21854081
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17355928
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13335009
26	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.06729182
27	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.01065814
28	Focal adhesion_Homo sapiens_hsa04510	1.00396402
29	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.97415796
30	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.96790085
31	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96766056
32	Endocytosis_Homo sapiens_hsa04144	0.96425927
33	Pyruvate metabolism_Homo sapiens_hsa00620	0.96229023
34	Pentose phosphate pathway_Homo sapiens_hsa00030	0.95733543
35	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.95628298
36	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.87340432
37	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86490296
38	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.85551487
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83605660
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83535434
41	Apoptosis_Homo sapiens_hsa04210	0.82572251
42	Hepatitis C_Homo sapiens_hsa05160	0.80035102
43	p53 signaling pathway_Homo sapiens_hsa04115	0.79232849
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78697975
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78466789
46	VEGF signaling pathway_Homo sapiens_hsa04370	0.78009510
47	Shigellosis_Homo sapiens_hsa05131	0.76955019
48	Notch signaling pathway_Homo sapiens_hsa04330	0.74135859
49	Insulin resistance_Homo sapiens_hsa04931	0.74099267
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70138285
51	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.68332060
52	Axon guidance_Homo sapiens_hsa04360	0.67869774
53	Proteoglycans in cancer_Homo sapiens_hsa05205	0.67640474
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66639364
55	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.65036274
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.64700633
57	Pancreatic cancer_Homo sapiens_hsa05212	0.63904462
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63855636
59	RNA polymerase_Homo sapiens_hsa03020	0.61311166
60	Thyroid cancer_Homo sapiens_hsa05216	0.61173507
61	TNF signaling pathway_Homo sapiens_hsa04668	0.60660226
62	mTOR signaling pathway_Homo sapiens_hsa04150	0.58924040
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56435033
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56232033
65	Adherens junction_Homo sapiens_hsa04520	0.53973531
66	ErbB signaling pathway_Homo sapiens_hsa04012	0.48530437
67	Base excision repair_Homo sapiens_hsa03410	0.47455680
68	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.46689074
69	Tight junction_Homo sapiens_hsa04530	0.43549051
70	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.43429863
71	Salmonella infection_Homo sapiens_hsa05132	0.43284701
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41854422
73	Lysosome_Homo sapiens_hsa04142	0.40673403
74	Histidine metabolism_Homo sapiens_hsa00340	0.40057430
75	Other glycan degradation_Homo sapiens_hsa00511	0.39454998
76	Endometrial cancer_Homo sapiens_hsa05213	0.36284871
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.36018809
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.35349501
79	MicroRNAs in cancer_Homo sapiens_hsa05206	0.35000150
80	Cell cycle_Homo sapiens_hsa04110	0.34907971
81	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33986386
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33898882
83	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.33686314
84	Mineral absorption_Homo sapiens_hsa04978	0.32546809
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32462344
86	Metabolic pathways_Homo sapiens_hsa01100	0.32019363
87	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.31743642
88	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30650001
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29999100
90	Amoebiasis_Homo sapiens_hsa05146	0.29690246
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29439203
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.29423921
93	Lysine degradation_Homo sapiens_hsa00310	0.28538586
94	Fanconi anemia pathway_Homo sapiens_hsa03460	0.27134569
95	Pathways in cancer_Homo sapiens_hsa05200	0.26793115
96	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.26647364
97	Arginine biosynthesis_Homo sapiens_hsa00220	0.26076880
98	Non-small cell lung cancer_Homo sapiens_hsa05223	0.25714078
99	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.24920874
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.24858877

KRT87P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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