KRT87P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.94597481
2GDP-mannose metabolic process (GO:0019673)7.45088632
3desmosome organization (GO:0002934)7.01587369
4negative regulation of cell aging (GO:0090344)6.30471180
5G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.76382745
6protein carboxylation (GO:0018214)5.24182416
7peptidyl-glutamic acid carboxylation (GO:0017187)5.24182416
8nucleotide-sugar biosynthetic process (GO:0009226)5.19501252
9cellular response to ATP (GO:0071318)5.12448949
10DNA strand renaturation (GO:0000733)5.06096656
11mitotic cell cycle arrest (GO:0071850)5.01414549
12polyketide metabolic process (GO:0030638)4.91514674
13doxorubicin metabolic process (GO:0044598)4.91514674
14daunorubicin metabolic process (GO:0044597)4.91514674
15regulation of skeletal muscle contraction (GO:0014819)4.82383493
16type B pancreatic cell proliferation (GO:0044342)4.75637160
17positive regulation of keratinocyte differentiation (GO:0045618)4.69688549
18lens fiber cell differentiation (GO:0070306)4.61794491
19semaphorin-plexin signaling pathway (GO:0071526)4.39510427
20cell-substrate junction assembly (GO:0007044)4.38230144
21aminoglycoside antibiotic metabolic process (GO:0030647)4.36203655
22positive regulation of epidermal cell differentiation (GO:0045606)4.34081974
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.24154284
24cellular response to vitamin D (GO:0071305)4.14275847
25adenosine receptor signaling pathway (GO:0001973)4.11780431
26meiotic chromosome segregation (GO:0045132)4.05674509
27regulation of cytokine production involved in inflammatory response (GO:1900015)4.05047526
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.98652452
29protein retention in ER lumen (GO:0006621)3.98428282
30purinergic nucleotide receptor signaling pathway (GO:0035590)3.81340148
31sphingosine metabolic process (GO:0006670)3.77243917
32activation of Rac GTPase activity (GO:0032863)3.72651256
33adenine nucleotide transport (GO:0051503)3.71316579
34proline biosynthetic process (GO:0006561)3.63420792
35regulation of translational fidelity (GO:0006450)3.62482769
36positive regulation of epidermis development (GO:0045684)3.61208844
37transepithelial transport (GO:0070633)3.55788054
38purine ribonucleotide transport (GO:0015868)3.53799249
39regulation of cell aging (GO:0090342)3.50741488
40regulation of synapse structural plasticity (GO:0051823)3.46511297
41G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.46227359
42diol metabolic process (GO:0034311)3.45639822
43bundle of His cell to Purkinje myocyte communication (GO:0086069)3.43588151
44cell-substrate adherens junction assembly (GO:0007045)3.43050939
45focal adhesion assembly (GO:0048041)3.43050939
46regulation of water loss via skin (GO:0033561)3.38885023
47estrogen biosynthetic process (GO:0006703)3.36291754
48response to gravity (GO:0009629)3.32911296
49rRNA methylation (GO:0031167)3.31591160
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.28815124
51establishment of skin barrier (GO:0061436)3.27137428
52negative regulation of keratinocyte proliferation (GO:0010839)3.26198125
53COPI coating of Golgi vesicle (GO:0048205)3.25291772
54Golgi transport vesicle coating (GO:0048200)3.25291772
55keratinocyte development (GO:0003334)3.24207163
56protein hydroxylation (GO:0018126)3.22392056
57sphingomyelin metabolic process (GO:0006684)3.22211573
58UV protection (GO:0009650)3.21101575
59actin filament bundle organization (GO:0061572)3.21050786
60actin filament bundle assembly (GO:0051017)3.21050786
61folic acid metabolic process (GO:0046655)3.18214050
62phosphate ion transmembrane transport (GO:0035435)3.16616371
63regulation of phospholipid biosynthetic process (GO:0071071)3.14276824
64rRNA modification (GO:0000154)3.08981127
65cell adhesion mediated by integrin (GO:0033627)3.05719771
66cellular response to vitamin (GO:0071295)3.03423907
67cyclooxygenase pathway (GO:0019371)3.01833392
68endocytic recycling (GO:0032456)3.00287179
69cellular response to virus (GO:0098586)2.99639388
70mammary gland epithelial cell proliferation (GO:0033598)2.97193227
71sensory perception of taste (GO:0050909)2.97139865
72membrane raft organization (GO:0031579)2.91771541
73sphingoid metabolic process (GO:0046519)2.91531944
74regulation of apoptotic process involved in morphogenesis (GO:1902337)2.88249275
75epithelial cell-cell adhesion (GO:0090136)2.86979026
76atrioventricular valve morphogenesis (GO:0003181)2.86073536
77regulation of hippo signaling (GO:0035330)2.85721351
78peptidyl-proline hydroxylation (GO:0019511)2.85661847
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80669092
80purinergic receptor signaling pathway (GO:0035587)2.76663873
81protein localization to endosome (GO:0036010)2.76525274
82morphogenesis of embryonic epithelium (GO:0016331)2.76205301
83adherens junction assembly (GO:0034333)2.76109723
84negative regulation of interleukin-8 production (GO:0032717)2.75657272
85nuclear envelope reassembly (GO:0031468)2.75039418
86mitotic nuclear envelope reassembly (GO:0007084)2.75039418
87purine nucleotide transport (GO:0015865)2.74484302
88positive regulation of pseudopodium assembly (GO:0031274)2.74318044
89regulation of keratinocyte differentiation (GO:0045616)2.73885222
90regulation of vitamin metabolic process (GO:0030656)2.73818939
91surfactant homeostasis (GO:0043129)2.73350319
92endothelial cell chemotaxis (GO:0035767)2.71637876
93nucleotide transmembrane transport (GO:1901679)2.66994932
94response to ATP (GO:0033198)2.66064920
95negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63272517
96regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.62130005
97activation of NF-kappaB-inducing kinase activity (GO:0007250)2.58225089
98deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.56607888
99primary alcohol catabolic process (GO:0034310)2.56344987
100positive regulation of heat generation (GO:0031652)2.55382542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.76275252
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.46249454
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.28537841
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.89672866
5VDR_21846776_ChIP-Seq_THP-1_Human2.84049117
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66526033
7RACK7_27058665_Chip-Seq_MCF-7_Human2.55168204
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46497438
9LXR_22292898_ChIP-Seq_THP-1_Human2.45093176
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.35658415
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34603086
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.28753396
13P68_20966046_ChIP-Seq_HELA_Human2.17699531
14ATF3_27146783_Chip-Seq_COLON_Human2.15815247
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.01865125
16XRN2_22483619_ChIP-Seq_HELA_Human1.98226960
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88903474
18TP53_22127205_ChIP-Seq_IMR90_Human1.85156400
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78986564
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78986564
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.76255532
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76179172
23UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69404581
24UBF1/2_26484160_Chip-Seq_HMECs_Human1.65782033
25E2F1_20622854_ChIP-Seq_HELA_Human1.64630406
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63526612
27BCOR_27268052_Chip-Seq_Bcells_Human1.63404336
28P63_26484246_Chip-Seq_KERATINOCYTES_Human1.63299657
29ZNF263_19887448_ChIP-Seq_K562_Human1.63223533
30CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.61679389
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.61182789
32CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58150106
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57254508
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56452355
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.55716266
36MAF_26560356_Chip-Seq_TH2_Human1.55460470
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.51867561
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48924489
39SMC4_20622854_ChIP-Seq_HELA_Human1.48545210
40RARB_24833708_ChIP-Seq_LIVER_Mouse1.47957489
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46123074
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45442675
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45317792
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45247266
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45147427
46BCL6_27268052_Chip-Seq_Bcells_Human1.44346412
47RARA_24833708_ChIP-Seq_LIVER_Mouse1.41916733
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.40595833
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39457577
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39418649
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38811249
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37414104
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37369882
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.36827866
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35955371
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35207237
57MAF_26560356_Chip-Seq_TH1_Human1.34718687
58MYC_22102868_ChIP-Seq_BL_Human1.31887727
59CTCF_27219007_Chip-Seq_Bcells_Human1.30663374
60PHF8_20622854_ChIP-Seq_HELA_Human1.30601866
61CREB1_26743006_Chip-Seq_LNCaP_Human1.28449021
62VDR_24763502_ChIP-Seq_THP-1_Human1.28044348
63DCP1A_22483619_ChIP-Seq_HELA_Human1.27421921
64FOXP1_21924763_ChIP-Seq_HESCs_Human1.27157447
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27016067
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25334871
67CTCF_21964334_Chip-Seq_Bcells_Human1.24773075
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24322640
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22142108
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21880176
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21434698
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20353658
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19802844
74KDM2B_26808549_Chip-Seq_DND41_Human1.18471881
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18221165
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18216081
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18060933
78SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17646050
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15854791
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14638172
81TCF7_22412390_ChIP-Seq_EML_Mouse1.12017022
82TP63_22573176_ChIP-Seq_HFKS_Human1.11033850
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.10865605
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10735275
85CTCF_20526341_ChIP-Seq_ESCs_Human1.10009804
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08120669
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.06962175
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06831322
89FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06261348
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05954989
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04802137
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01943357
93GATA6_25053715_ChIP-Seq_YYC3_Human1.00749603
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98089601
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97492797
96GABP_19822575_ChIP-Seq_HepG2_Human0.96026594
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95885001
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95883416
99RXR_22158963_ChIP-Seq_LIVER_Mouse0.95505811
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95337149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.20153823
2MP0010234_abnormal_vibrissa_follicle3.47488351
3MP0005174_abnormal_tail_pigmentation3.35322872
4MP0003705_abnormal_hypodermis_morpholog3.21976795
5MP0003453_abnormal_keratinocyte_physiol3.18204780
6MP0000579_abnormal_nail_morphology3.01542656
7MP0001986_abnormal_taste_sensitivity2.90251701
8MP0003566_abnormal_cell_adhesion2.89538202
9MP0005083_abnormal_biliary_tract2.81656753
10MP0005501_abnormal_skin_physiology2.78274404
11MP0008875_abnormal_xenobiotic_pharmacok2.76615116
12MP0005423_abnormal_somatic_nervous2.73121206
13MP0001661_extended_life_span2.53351920
14MP0002796_impaired_skin_barrier2.45486868
15MP0005409_darkened_coat_color2.45373754
16MP0002060_abnormal_skin_morphology2.36198837
17MP0000751_myopathy2.35006960
18MP0005023_abnormal_wound_healing2.25625265
19MP0005330_cardiomyopathy2.24320681
20MP0003806_abnormal_nucleotide_metabolis2.19652891
21MP0001216_abnormal_epidermal_layer2.14845437
22MP0000013_abnormal_adipose_tissue2.14372025
23MP0000750_abnormal_muscle_regeneration1.90205530
24MP0004782_abnormal_surfactant_physiolog1.89836080
25MP0003091_abnormal_cell_migration1.85913249
26MP0000762_abnormal_tongue_morphology1.85364920
27MP0003941_abnormal_skin_development1.78996436
28MP0010771_integument_phenotype1.74096541
29MP0005076_abnormal_cell_differentiation1.73121819
30MP0000467_abnormal_esophagus_morphology1.70899136
31MP0005257_abnormal_intraocular_pressure1.68478725
32MP0004381_abnormal_hair_follicle1.61967724
33MP0000003_abnormal_adipose_tissue1.57955660
34MP0009053_abnormal_anal_canal1.52840122
35MP0003136_yellow_coat_color1.49370503
36MP0001756_abnormal_urination1.42042378
37MP0000537_abnormal_urethra_morphology1.41107147
38MP0003191_abnormal_cellular_cholesterol1.36421318
39MP0001348_abnormal_lacrimal_gland1.35985023
40MP0000858_altered_metastatic_potential1.35331103
41MP0005248_abnormal_Harderian_gland1.33235650
42MP0000377_abnormal_hair_follicle1.31085261
43MP0010678_abnormal_skin_adnexa1.30870501
44MP0002098_abnormal_vibrissa_morphology1.26301037
45MP0001873_stomach_inflammation1.25639601
46MP0001849_ear_inflammation1.24216584
47MP0009931_abnormal_skin_appearance1.18091853
48MP0009840_abnormal_foam_cell1.18071730
49MP0004947_skin_inflammation1.16640745
50MP0003950_abnormal_plasma_membrane1.15614695
51MP0002877_abnormal_melanocyte_morpholog1.15382259
52MP0001502_abnormal_circadian_rhythm1.15122950
53MP0000538_abnormal_urinary_bladder1.14756743
54MP0004957_abnormal_blastocyst_morpholog1.13983100
55MP0005410_abnormal_fertilization1.13494180
56MP0002160_abnormal_reproductive_system1.12387593
57MP0009780_abnormal_chondrocyte_physiolo1.12239660
58MP0000367_abnormal_coat/_hair1.10579599
59MP0001765_abnormal_ion_homeostasis1.09897552
60MP0004185_abnormal_adipocyte_glucose1.04471316
61MP0005375_adipose_tissue_phenotype1.03367281
62MP0000566_synostosis1.01846476
63MP0000358_abnormal_cell_content/1.00255597
64MP0002139_abnormal_hepatobiliary_system0.99564350
65MP0005360_urolithiasis0.97820750
66MP0002234_abnormal_pharynx_morphology0.96185923
67MP0003111_abnormal_nucleus_morphology0.94902470
68MP0001188_hyperpigmentation0.94488314
69MP0001919_abnormal_reproductive_system0.91571830
70MP0000383_abnormal_hair_follicle0.90862583
71MP0001191_abnormal_skin_condition0.90838832
72MP0004019_abnormal_vitamin_homeostasis0.90690679
73MP0003315_abnormal_perineum_morphology0.89657050
74MP0000470_abnormal_stomach_morphology0.89506324
75MP0000627_abnormal_mammary_gland0.88289258
76MP0009643_abnormal_urine_homeostasis0.88281776
77MP0005666_abnormal_adipose_tissue0.88194109
78MP0003448_altered_tumor_morphology0.87308922
79MP0000490_abnormal_crypts_of0.84382763
80MP0005584_abnormal_enzyme/coenzyme_acti0.83264600
81MP0000427_abnormal_hair_cycle0.81905444
82MP0005451_abnormal_body_composition0.80010230
83MP0005332_abnormal_amino_acid0.79844077
84MP0001243_abnormal_dermal_layer0.79130293
85MP0003077_abnormal_cell_cycle0.78067926
86MP0010030_abnormal_orbit_morphology0.77817196
87MP0004233_abnormal_muscle_weight0.77280041
88MP0001881_abnormal_mammary_gland0.77076380
89MP0002332_abnormal_exercise_endurance0.76083397
90MP0000747_muscle_weakness0.74555717
91MP0000015_abnormal_ear_pigmentation0.72795810
92MP0004272_abnormal_basement_membrane0.71759836
93MP0001340_abnormal_eyelid_morphology0.68139758
94MP0001958_emphysema0.68062952
95MP0002136_abnormal_kidney_physiology0.66525990
96MP0004197_abnormal_fetal_growth/weight/0.66127641
97MP0003656_abnormal_erythrocyte_physiolo0.65526227
98MP0002086_abnormal_extraembryonic_tissu0.64925628
99MP0005621_abnormal_cell_physiology0.64618114
100MP0000678_abnormal_parathyroid_gland0.63729665

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)5.91118087
2Popliteal pterygium (HP:0009756)5.46261900
3Poikiloderma (HP:0001029)5.30929363
4Ulnar bowing (HP:0003031)4.69438723
5Rib fusion (HP:0000902)4.42096497
6Thin bony cortex (HP:0002753)4.39567075
7Dyschromatopsia (HP:0007641)4.04257043
8Hypotrichosis (HP:0001006)3.98643132
9Abnormality of the intrinsic pathway (HP:0010989)3.98336253
10Nail dystrophy (HP:0008404)3.89930615
11Pterygium (HP:0001059)3.78247400
12Onycholysis (HP:0001806)3.72753628
13Abnormality of placental membranes (HP:0011409)3.66594296
14Amniotic constriction ring (HP:0009775)3.66594296
15Mesangial abnormality (HP:0001966)3.63870837
16Milia (HP:0001056)3.45732375
17Akinesia (HP:0002304)3.42200484
18Choroideremia (HP:0001139)3.40756369
19Attenuation of retinal blood vessels (HP:0007843)3.37182900
20Annular pancreas (HP:0001734)3.33690749
21Facial hemangioma (HP:0000329)3.30016473
22Increased hepatocellular lipid droplets (HP:0006565)3.25690551
23Atrioventricular block (HP:0001678)3.25642830
24Renal Fanconi syndrome (HP:0001994)3.24890840
25Brittle hair (HP:0002299)3.24147117
26Hemorrhage of the eye (HP:0011885)3.21265549
27Prolonged partial thromboplastin time (HP:0003645)3.21240373
28Short chin (HP:0000331)3.21209582
29Facial diplegia (HP:0001349)3.18964832
30Squamous cell carcinoma (HP:0002860)3.17614633
31Hypoalbuminemia (HP:0003073)3.15321172
32Abnormal albumin level (HP:0012116)3.15321172
33Coronal craniosynostosis (HP:0004440)3.11289958
34Turricephaly (HP:0000262)3.09523851
35Aplasia of the musculature (HP:0100854)3.06998084
36Lipid accumulation in hepatocytes (HP:0006561)3.05800249
37Atrophic scars (HP:0001075)3.04613390
38Bowed forearm bones (HP:0003956)3.00591203
39Bowing of the arm (HP:0006488)3.00591203
40Joint hemorrhage (HP:0005261)2.97207953
41Pili torti (HP:0003777)2.96092302
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93739855
43Cheilitis (HP:0100825)2.88180705
44Rectal fistula (HP:0100590)2.81467633
45Rectovaginal fistula (HP:0000143)2.81467633
46Vaginal fistula (HP:0004320)2.80463336
47Abnormality of nail color (HP:0100643)2.78172983
48Plantar hyperkeratosis (HP:0007556)2.74508803
49Fetal akinesia sequence (HP:0001989)2.70383132
50Intestinal fistula (HP:0100819)2.63001389
51Delayed epiphyseal ossification (HP:0002663)2.62604409
52Chorioretinal atrophy (HP:0000533)2.59597451
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59233259
54Cervical subluxation (HP:0003308)2.56737761
55Neonatal respiratory distress (HP:0002643)2.53466470
56Zonular cataract (HP:0010920)2.45515246
57Broad face (HP:0000283)2.40759915
58Abnormality of the neuromuscular junction (HP:0003398)2.35291522
59Fatigable weakness (HP:0003473)2.35291522
60Anteriorly placed anus (HP:0001545)2.35047751
61Abnormality of the costochondral junction (HP:0000919)2.32322806
62Fragile nails (HP:0001808)2.29989763
63Neonatal onset (HP:0003623)2.29133111
64Joint stiffness (HP:0001387)2.28763825
65Diminished movement (HP:0002374)2.26610709
66Lip pit (HP:0100267)2.25000050
67Tibial bowing (HP:0002982)2.24205773
68Increased intramyocellular lipid droplets (HP:0012240)2.21034400
69Enlarged epiphyses (HP:0010580)2.20692008
70Decreased central vision (HP:0007663)2.19304378
71Short humerus (HP:0005792)2.18912132
72Abnormal atrioventricular conduction (HP:0005150)2.18101761
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15447433
74Vertebral clefting (HP:0008428)2.13389868
75Increased muscle lipid content (HP:0009058)2.12665115
76Right ventricular cardiomyopathy (HP:0011663)2.12396811
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08393315
78Abnormal hair laboratory examination (HP:0003328)2.07576832
79Hypophosphatemic rickets (HP:0004912)2.07498279
80Capillary hemangiomas (HP:0005306)2.06114338
81Fused cervical vertebrae (HP:0002949)2.05390209
82Bony spicule pigmentary retinopathy (HP:0007737)2.01851108
83Aplasia/hypoplasia of the humerus (HP:0006507)2.01544925
84Palmoplantar hyperkeratosis (HP:0000972)2.01470575
85Ridged nail (HP:0001807)1.99337145
86Absent thumb (HP:0009777)1.95790823
87Abnormality of renal resorption (HP:0011038)1.95373265
88Widely patent fontanelles and sutures (HP:0004492)1.92674581
89Myotonia (HP:0002486)1.92284585
90Heart block (HP:0012722)1.91556230
91Abnormality of the common coagulation pathway (HP:0010990)1.90536654
92Bifid uvula (HP:0000193)1.89939287
93Patellar aplasia (HP:0006443)1.88810450
94Hypoplasia of dental enamel (HP:0006297)1.87819883
95Fragile skin (HP:0001030)1.87440973
96Thick nail (HP:0001805)1.87144169
97Flat occiput (HP:0005469)1.86901496
98Hypoplasia of the uterus (HP:0000013)1.86679773
99Congenital stationary night blindness (HP:0007642)1.84620178
100Aplasia/Hypoplasia of the patella (HP:0006498)1.84343152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.85759252
2MAPK154.99556882
3MST1R4.71229625
4MET3.33519274
5ARAF2.96583076
6LMTK22.95249182
7NME22.84817402
8TESK22.81119544
9MAP3K92.32477918
10ERN12.31068579
11TRIB32.28462125
12IRAK32.28066356
13MUSK2.20810204
14TESK11.91829372
15PTK21.83059470
16SIK11.75875798
17EPHB11.69253928
18FLT31.62919982
19PIM21.58472537
20PAK41.57801657
21NTRK11.52446814
22TTN1.48207656
23WNK41.47847075
24EPHB21.44144318
25SIK31.37873132
26LIMK11.21034137
27BMX1.08538055
28MAP3K131.07777807
29LATS21.07587743
30PHKG11.04376422
31PHKG21.04376422
32PDGFRA0.99655368
33MAPKAPK30.98336315
34TGFBR20.90638044
35TBK10.88205770
36STK160.88203661
37TLK10.82595163
38ERBB40.81797213
39MOS0.81789711
40MAP3K30.80476652
41PRKD20.80305638
42SMG10.79818375
43LATS10.79291356
44BUB10.75625105
45STK100.74648699
46ICK0.73624703
47RAF10.70897726
48MAP3K120.70787341
49STK380.70459649
50ADRBK10.69517932
51PBK0.67931020
52PRKCI0.67570396
53MAP3K140.66770359
54PKN20.66053373
55PDPK10.65916307
56ILK0.65688014
57IRAK20.64659481
58MAPK110.64051826
59TRIM280.61563359
60NEK10.60773660
61AURKA0.60689725
62ABL20.59844145
63EIF2AK10.59173003
64RIPK10.58979985
65GRK60.58078720
66BRAF0.57336711
67ZAP700.56990528
68CDK120.56651092
69MTOR0.54058218
70RPS6KA20.52146142
71PAK10.51446827
72PTK60.50172446
73CCNB10.49895921
74KSR10.43314092
75IKBKB0.43204683
76CDK60.41156355
77CDK180.40534432
78SIK20.40258922
79MAP2K20.39603304
80TRPM70.39215763
81CDK150.38453479
82CDC42BPA0.37527998
83MAPKAPK20.36813287
84CDK80.35925311
85MAP2K10.34755487
86CHUK0.33570169
87CDK11A0.33117925
88MELK0.32807370
89BLK0.31217164
90RPS6KB20.29992825
91VRK20.29349899
92MAP3K80.28932024
93PRKD10.26526726
94MATK0.26526157
95PDGFRB0.26494739
96CDK40.25780638
97PTK2B0.25381183
98MST40.25284616
99KSR20.23936277
100NEK20.23840988

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.70039445
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.03551857
3Sulfur relay system_Homo sapiens_hsa041224.14999186
4Fructose and mannose metabolism_Homo sapiens_hsa000513.35193465
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.19753600
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.50424713
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.41850427
8Galactose metabolism_Homo sapiens_hsa000521.97411718
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.94473017
10Sphingolipid metabolism_Homo sapiens_hsa006001.92418351
11Circadian rhythm_Homo sapiens_hsa047101.83657593
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60463674
13Bladder cancer_Homo sapiens_hsa052191.57427231
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55567979
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35522442
16Hippo signaling pathway_Homo sapiens_hsa043901.33199164
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.33081126
18Small cell lung cancer_Homo sapiens_hsa052221.31366979
19ECM-receptor interaction_Homo sapiens_hsa045121.28361092
20Sulfur metabolism_Homo sapiens_hsa009201.26197490
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22252811
22Phenylalanine metabolism_Homo sapiens_hsa003601.21856321
23Glutathione metabolism_Homo sapiens_hsa004801.21854081
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17355928
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13335009
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06729182
27N-Glycan biosynthesis_Homo sapiens_hsa005101.01065814
28Focal adhesion_Homo sapiens_hsa045101.00396402
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97415796
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96790085
31Pyrimidine metabolism_Homo sapiens_hsa002400.96766056
32Endocytosis_Homo sapiens_hsa041440.96425927
33Pyruvate metabolism_Homo sapiens_hsa006200.96229023
34Pentose phosphate pathway_Homo sapiens_hsa000300.95733543
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95628298
36Chronic myeloid leukemia_Homo sapiens_hsa052200.87340432
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86490296
38Biosynthesis of amino acids_Homo sapiens_hsa012300.85551487
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83605660
40Hedgehog signaling pathway_Homo sapiens_hsa043400.83535434
41Apoptosis_Homo sapiens_hsa042100.82572251
42Hepatitis C_Homo sapiens_hsa051600.80035102
43p53 signaling pathway_Homo sapiens_hsa041150.79232849
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78697975
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78466789
46VEGF signaling pathway_Homo sapiens_hsa043700.78009510
47Shigellosis_Homo sapiens_hsa051310.76955019
48Notch signaling pathway_Homo sapiens_hsa043300.74135859
49Insulin resistance_Homo sapiens_hsa049310.74099267
50Glycerolipid metabolism_Homo sapiens_hsa005610.70138285
51Inositol phosphate metabolism_Homo sapiens_hsa005620.68332060
52Axon guidance_Homo sapiens_hsa043600.67869774
53Proteoglycans in cancer_Homo sapiens_hsa052050.67640474
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.66639364
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65036274
56Vitamin digestion and absorption_Homo sapiens_hsa049770.64700633
57Pancreatic cancer_Homo sapiens_hsa052120.63904462
58Ovarian steroidogenesis_Homo sapiens_hsa049130.63855636
59RNA polymerase_Homo sapiens_hsa030200.61311166
60Thyroid cancer_Homo sapiens_hsa052160.61173507
61TNF signaling pathway_Homo sapiens_hsa046680.60660226
62mTOR signaling pathway_Homo sapiens_hsa041500.58924040
63Chemical carcinogenesis_Homo sapiens_hsa052040.56435033
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56232033
65Adherens junction_Homo sapiens_hsa045200.53973531
66ErbB signaling pathway_Homo sapiens_hsa040120.48530437
67Base excision repair_Homo sapiens_hsa034100.47455680
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46689074
69Tight junction_Homo sapiens_hsa045300.43549051
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43429863
71Salmonella infection_Homo sapiens_hsa051320.43284701
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41854422
73Lysosome_Homo sapiens_hsa041420.40673403
74Histidine metabolism_Homo sapiens_hsa003400.40057430
75Other glycan degradation_Homo sapiens_hsa005110.39454998
76Endometrial cancer_Homo sapiens_hsa052130.36284871
77Steroid biosynthesis_Homo sapiens_hsa001000.36018809
78Basal cell carcinoma_Homo sapiens_hsa052170.35349501
79MicroRNAs in cancer_Homo sapiens_hsa052060.35000150
80Cell cycle_Homo sapiens_hsa041100.34907971
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33986386
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.33898882
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33686314
84Mineral absorption_Homo sapiens_hsa049780.32546809
85Arginine and proline metabolism_Homo sapiens_hsa003300.32462344
86Metabolic pathways_Homo sapiens_hsa011000.32019363
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.31743642
88Acute myeloid leukemia_Homo sapiens_hsa052210.30650001
89Vitamin B6 metabolism_Homo sapiens_hsa007500.29999100
90Amoebiasis_Homo sapiens_hsa051460.29690246
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29439203
92Tyrosine metabolism_Homo sapiens_hsa003500.29423921
93Lysine degradation_Homo sapiens_hsa003100.28538586
94Fanconi anemia pathway_Homo sapiens_hsa034600.27134569
95Pathways in cancer_Homo sapiens_hsa052000.26793115
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26647364
97Arginine biosynthesis_Homo sapiens_hsa002200.26076880
98Non-small cell lung cancer_Homo sapiens_hsa052230.25714078
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.24920874
100Insulin signaling pathway_Homo sapiens_hsa049100.24858877

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