KRT89P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)9.46293595
2regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00437.46601365
3regulation of RIG-I signaling pathway (GO:0039535)6.97713839
4positive regulation of hormone biosynthetic process (GO:0046886)6.53131784
5positive regulation of hormone metabolic process (GO:0032352)6.08202100
6regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)6.07070365
7sleep (GO:0030431)5.88591726
8positive regulation of protein sumoylation (GO:0033235)5.49654116
9regulation of interleukin-13 production (GO:0032656)5.21319500
10mRNA transcription from RNA polymerase II promoter (GO:0042789)5.01916422
11chaperone mediated protein folding requiring cofactor (GO:0051085)4.95708203
12tolerance induction (GO:0002507)4.66616464
13positive regulation of T cell cytokine production (GO:0002726)4.62722716
14negative regulation of heart rate (GO:0010459)4.62094910
15negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.42874317
16negative regulation of T cell mediated immunity (GO:0002710)4.36140325
17regulation of establishment of cell polarity (GO:2000114)4.33434976
18negative regulation of interleukin-2 production (GO:0032703)4.31097927
19regulation of leukocyte mediated cytotoxicity (GO:0001910)4.30346354
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.29071240
21positive regulation of glycolytic process (GO:0045821)4.28174105
22adenosine metabolic process (GO:0046085)4.26856024
23positive regulation of T-helper 1 type immune response (GO:0002827)4.24571711
24regulation of glomerular filtration (GO:0003093)4.23744498
25positive regulation of defense response to virus by host (GO:0002230)4.21078806
26mRNA transcription (GO:0009299)4.17733491
27positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.17507682
28cellular response to interleukin-15 (GO:0071350)4.16873015
29positive regulation of natural killer cell mediated immunity (GO:0002717)4.12297151
30CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.09003532
31T-helper cell differentiation (GO:0042093)4.09003532
32regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.04710622
33regulation of natural killer cell mediated immunity (GO:0002715)4.04710622
34regulation of T cell mediated cytotoxicity (GO:0001914)3.97892621
35regulation of interleukin-5 production (GO:0032674)3.89625641
36regulation of protein sumoylation (GO:0033233)3.89296372
37positive regulation of T cell mediated cytotoxicity (GO:0001916)3.87606570
38regulation of establishment or maintenance of cell polarity (GO:0032878)3.81218313
39negative regulation of reactive oxygen species metabolic process (GO:2000378)3.77751079
40regulation of cell killing (GO:0031341)3.77403329
41L-fucose catabolic process (GO:0042355)3.70345859
42fucose catabolic process (GO:0019317)3.70345859
43L-fucose metabolic process (GO:0042354)3.70345859
44positive regulation of cell killing (GO:0031343)3.65526404
45natural killer cell activation involved in immune response (GO:0002323)3.61635449
46positive regulation of circadian rhythm (GO:0042753)3.61503375
47positive regulation of fibroblast migration (GO:0010763)3.56253699
48response to testosterone (GO:0033574)3.51965411
49T cell differentiation involved in immune response (GO:0002292)3.51797722
50alpha-beta T cell differentiation involved in immune response (GO:0002293)3.51797722
51alpha-beta T cell activation involved in immune response (GO:0002287)3.51797722
52regulation of T cell chemotaxis (GO:0010819)3.50849828
53positive regulation of T cell chemotaxis (GO:0010820)3.50849828
54regulation of T-helper 1 type immune response (GO:0002825)3.50771777
55cellular response to nicotine (GO:0071316)3.48849669
56regulation of germinal center formation (GO:0002634)3.43809855
57mast cell activation involved in immune response (GO:0002279)3.42685849
58mast cell degranulation (GO:0043303)3.42685849
59positive regulation of prostaglandin secretion (GO:0032308)3.41986110
60positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.39489733
61lymph node development (GO:0048535)3.37729658
62response to misfolded protein (GO:0051788)3.34290047
63tumor necrosis factor-mediated signaling pathway (GO:0033209)3.29519992
64mRNA cleavage (GO:0006379)3.29100596
65cellular response to interleukin-4 (GO:0071353)3.25907205
66protein deneddylation (GO:0000338)3.25675841
67response to interleukin-15 (GO:0070672)3.22626377
68negative regulation of multicellular organism growth (GO:0040015)3.20789153
69leukocyte degranulation (GO:0043299)3.20400023
70folic acid-containing compound biosynthetic process (GO:0009396)3.16347587
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13744554
72negative regulation of cell killing (GO:0031342)3.13744554
73macroautophagy (GO:0016236)3.11961957
74NIK/NF-kappaB signaling (GO:0038061)3.10175348
75positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.10118185
76positive regulation of cell fate commitment (GO:0010455)3.07821564
77positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.07655282
78nucleoside diphosphate catabolic process (GO:0009134)3.05213663
79L-alpha-amino acid transmembrane transport (GO:1902475)3.03356362
80trivalent inorganic anion homeostasis (GO:0072506)3.03070518
81phosphate ion homeostasis (GO:0055062)3.03070518
82N-glycan processing (GO:0006491)3.00645406
83positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.00563955
84regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.00082732
85regulation of T cell cytokine production (GO:0002724)2.99800015
86positive regulation of heat generation (GO:0031652)2.98235864
87positive regulation of osteoclast differentiation (GO:0045672)2.96548956
88regulation of defense response to virus by host (GO:0050691)2.94124466
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92485343
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92422697
91positive regulation of erythrocyte differentiation (GO:0045648)2.90902595
92regulation of activation of Janus kinase activity (GO:0010533)2.90352879
93protein polyglutamylation (GO:0018095)2.86549988
94positive regulation vascular endothelial growth factor production (GO:0010575)2.86187293
95cytoplasmic mRNA processing body assembly (GO:0033962)2.85746509
96termination of RNA polymerase I transcription (GO:0006363)2.85073779
97hepatocyte apoptotic process (GO:0097284)2.84907262
98regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.82650264
99positive regulation of T cell mediated immunity (GO:0002711)2.82331166
100renal system process involved in regulation of blood volume (GO:0001977)2.81601157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human6.05257023
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.95908484
3IRF1_19129219_ChIP-ChIP_H3396_Human3.38857850
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.36942684
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33743028
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.10834641
7GATA1_22025678_ChIP-Seq_K562_Human3.05500355
8FLI1_27457419_Chip-Seq_LIVER_Mouse3.01459727
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35709813
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28686925
11TDRD3_21172665_ChIP-Seq_MCF-7_Human2.21882301
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.07733774
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.04187077
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02161947
15AHR_22903824_ChIP-Seq_MCF-7_Human1.99388854
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95400440
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.90428600
18MYB_26560356_Chip-Seq_TH2_Human1.88492937
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84635018
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82992274
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.75696774
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.74537305
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70510232
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69952560
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67638607
26VDR_23849224_ChIP-Seq_CD4+_Human1.67055570
27RUNX_20019798_ChIP-Seq_JUKART_Human1.66000248
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65042089
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59932391
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56128299
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.55149423
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46772845
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46673353
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41297918
35GATA3_26560356_Chip-Seq_TH2_Human1.40660799
36ERA_21632823_ChIP-Seq_H3396_Human1.39124255
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37800846
38ER_23166858_ChIP-Seq_MCF-7_Human1.37257646
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.35793420
40FOXP3_21729870_ChIP-Seq_TREG_Human1.31601024
41STAT1_20625510_ChIP-Seq_HELA_Human1.31233359
42PHF8_20622854_ChIP-Seq_HELA_Human1.30719742
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28932876
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28166825
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27894711
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26270416
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25957945
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23827127
49P68_20966046_ChIP-Seq_HELA_Human1.17716461
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16714751
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.15528569
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15092651
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.14867129
54GATA3_27048872_Chip-Seq_THYMUS_Human1.12944558
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12835342
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11900844
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11375699
58SPI1_23547873_ChIP-Seq_NB4_Human1.10639331
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10060152
60GATA6_25053715_ChIP-Seq_YYC3_Human1.09201482
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.08844962
62P53_21459846_ChIP-Seq_SAOS-2_Human1.07907040
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07827357
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06780702
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06234522
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05146382
67HOXB7_26014856_ChIP-Seq_BT474_Human1.05111319
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05003038
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04921559
70NANOG_20526341_ChIP-Seq_ESCs_Human1.04635801
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04146699
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03563242
73BCOR_27268052_Chip-Seq_Bcells_Human1.01947860
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.01494394
75MAF_26560356_Chip-Seq_TH2_Human1.00092501
76E2F1_20622854_ChIP-Seq_HELA_Human0.99927329
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98590325
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97370349
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96970366
80ELK1_19687146_ChIP-ChIP_HELA_Human0.96625270
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96566488
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94454725
83MYC_18940864_ChIP-ChIP_HL60_Human0.94225975
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93474939
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93411634
86OCT4_20526341_ChIP-Seq_ESCs_Human0.91942258
87MAF_26560356_Chip-Seq_TH1_Human0.91105459
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.89814573
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89014038
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88735306
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87867058
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86967817
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86893279
94TP53_22573176_ChIP-Seq_HFKS_Human0.86567255
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86137294
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85229482
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84920317
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84648507
99GATA4_25053715_ChIP-Seq_YYC3_Human0.83762106
100CTCF_20526341_ChIP-Seq_ESCs_Human0.82885223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005075_abnormal_melanosome_morpholog5.95144205
2MP0002877_abnormal_melanocyte_morpholog4.56604120
3MP0002796_impaired_skin_barrier3.90511278
4MP0004381_abnormal_hair_follicle3.30679699
5MP0005671_abnormal_response_to3.23642009
6MP0003878_abnormal_ear_physiology2.89874338
7MP0005377_hearing/vestibular/ear_phenot2.89874338
8MP0003724_increased_susceptibility_to2.85487266
9MP0004264_abnormal_extraembryonic_tissu2.79970126
10MP0004147_increased_porphyrin_level2.32399046
11MP0005501_abnormal_skin_physiology2.23784318
12MP0001790_abnormal_immune_system2.16280902
13MP0005387_immune_system_phenotype2.16280902
14MP0000465_gastrointestinal_hemorrhage2.14088135
15MP0000372_irregular_coat_pigmentation2.13176726
16MP0001881_abnormal_mammary_gland2.00339945
17MP0002736_abnormal_nociception_after1.99098815
18MP0000685_abnormal_immune_system1.98115474
19MP0003638_abnormal_response/metabolism_1.79211105
20MP0003763_abnormal_thymus_physiology1.79082366
21MP0005174_abnormal_tail_pigmentation1.77247634
22MP0003195_calcinosis1.76401064
23MP0004885_abnormal_endolymph1.66933587
24MP0000371_diluted_coat_color1.66192349
25MP0001853_heart_inflammation1.64121312
26MP0001873_stomach_inflammation1.63849609
27MP0000383_abnormal_hair_follicle1.60282925
28MP0000627_abnormal_mammary_gland1.57268744
29MP0003011_delayed_dark_adaptation1.52395143
30MP0005000_abnormal_immune_tolerance1.49388633
31MP0003828_pulmonary_edema1.45778390
32MP0002102_abnormal_ear_morphology1.43735193
33MP0003879_abnormal_hair_cell1.39451757
34MP0004043_abnormal_pH_regulation1.39109790
35MP0004947_skin_inflammation1.38315300
36MP0003303_peritoneal_inflammation1.37164939
37MP0008872_abnormal_physiological_respon1.36224608
38MP0003252_abnormal_bile_duct1.34046155
39MP0009780_abnormal_chondrocyte_physiolo1.31002096
40MP0000569_abnormal_digit_pigmentation1.29281896
41MP0001800_abnormal_humoral_immune1.29027297
42MP0001968_abnormal_touch/_nociception1.28420750
43MP0002723_abnormal_immune_serum1.26599896
44MP0008875_abnormal_xenobiotic_pharmacok1.25560816
45MP0001819_abnormal_immune_cell1.25455561
46MP0003453_abnormal_keratinocyte_physiol1.25417338
47MP0002098_abnormal_vibrissa_morphology1.25053340
48MP0001216_abnormal_epidermal_layer1.22644997
49MP0002420_abnormal_adaptive_immunity1.22248389
50MP0005408_hypopigmentation1.20717718
51MP0000427_abnormal_hair_cycle1.11810732
52MP0001835_abnormal_antigen_presentation1.11641465
53MP0003866_abnormal_defecation1.11325045
54MP0010771_integument_phenotype1.10307639
55MP0001188_hyperpigmentation1.09189417
56MP0002452_abnormal_antigen_presenting1.09020452
57MP0002876_abnormal_thyroid_physiology1.08722396
58MP0003806_abnormal_nucleotide_metabolis1.08044242
59MP0002722_abnormal_immune_system1.07334737
60MP0002933_joint_inflammation1.03682735
61MP0000367_abnormal_coat/_hair1.00800560
62MP0000377_abnormal_hair_follicle1.00191735
63MP0000716_abnormal_immune_system1.00187009
64MP0003936_abnormal_reproductive_system0.99659404
65MP0002405_respiratory_system_inflammati0.98751145
66MP0001664_abnormal_digestion0.97029482
67MP0002148_abnormal_hypersensitivity_rea0.95247497
68MP0001529_abnormal_vocalization0.94532552
69MP0000609_abnormal_liver_physiology0.93543806
70MP0001485_abnormal_pinna_reflex0.91962972
71MP0005410_abnormal_fertilization0.90734049
72MP0002938_white_spotting0.90302318
73MP0003786_premature_aging0.90163241
74MP0000689_abnormal_spleen_morphology0.89717198
75MP0002075_abnormal_coat/hair_pigmentati0.89610359
76MP0010678_abnormal_skin_adnexa0.89173018
77MP0002429_abnormal_blood_cell0.88837559
78MP0006035_abnormal_mitochondrial_morpho0.85842026
79MP0001905_abnormal_dopamine_level0.81748418
80MP0000703_abnormal_thymus_morphology0.80733573
81MP0002398_abnormal_bone_marrow0.79891620
82MP0008874_decreased_physiological_sensi0.79049814
83MP0006072_abnormal_retinal_apoptosis0.77580857
84MP0002138_abnormal_hepatobiliary_system0.77370942
85MP0001845_abnormal_inflammatory_respons0.76765587
86MP0003172_abnormal_lysosome_physiology0.76181656
87MP0000015_abnormal_ear_pigmentation0.74806067
88MP0008789_abnormal_olfactory_epithelium0.74675675
89MP0006036_abnormal_mitochondrial_physio0.74273488
90MP0000538_abnormal_urinary_bladder0.73347858
91MP0001851_eye_inflammation0.72952876
92MP0002277_abnormal_respiratory_mucosa0.71008182
93MP0004019_abnormal_vitamin_homeostasis0.70291943
94MP0001765_abnormal_ion_homeostasis0.69056648
95MP0000358_abnormal_cell_content/0.69001174
96MP0008260_abnormal_autophagy0.67712170
97MP0005076_abnormal_cell_differentiation0.66565664
98MP0000462_abnormal_digestive_system0.66331656
99MP0005360_urolithiasis0.65848795
100MP0001727_abnormal_embryo_implantation0.65177834

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)5.90557572
2Hypotrichosis (HP:0001006)5.88169378
3Genetic anticipation (HP:0003743)4.68183261
4Abnormality of dental color (HP:0011073)4.01083914
5Dysmetric saccades (HP:0000641)3.99719398
6Anhidrosis (HP:0000970)3.89970058
7Slow saccadic eye movements (HP:0000514)3.72378122
8Prostate neoplasm (HP:0100787)3.48331888
9Severe combined immunodeficiency (HP:0004430)3.41009325
10Slow-growing hair (HP:0002217)3.27889760
11Abnormality of hair growth rate (HP:0011363)3.27889760
12Abnormality of eosinophils (HP:0001879)3.13124730
13Conical tooth (HP:0000698)3.12843478
14IgG deficiency (HP:0004315)2.98637897
15Progressive cerebellar ataxia (HP:0002073)2.96335789
16Hypophosphatemic rickets (HP:0004912)2.93640303
17Nail dystrophy (HP:0008404)2.86258311
18Facial shape deformation (HP:0011334)2.83700188
19Potter facies (HP:0002009)2.83700188
20Optic neuritis (HP:0100653)2.79792370
21Retrobulbar optic neuritis (HP:0100654)2.79792370
22T lymphocytopenia (HP:0005403)2.76567952
23Renal cortical cysts (HP:0000803)2.74184603
24Progressive muscle weakness (HP:0003323)2.62140735
25J-shaped sella turcica (HP:0002680)2.61607448
26Abnormality of the frontal sinuses (HP:0002687)2.60950455
273-Methylglutaconic aciduria (HP:0003535)2.60439351
28Pili torti (HP:0003777)2.58376510
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55203083
30Combined immunodeficiency (HP:0005387)2.49252739
31Abnormality of T cell number (HP:0011839)2.47099049
32Abnormality of T cells (HP:0002843)2.45897531
33Bulbar palsy (HP:0001283)2.44903270
34Abnormality of the renal cortex (HP:0011035)2.44677883
35Rhinitis (HP:0012384)2.44259144
36Onycholysis (HP:0001806)2.40369351
37Molar tooth sign on MRI (HP:0002419)2.40350400
38Abnormality of midbrain morphology (HP:0002418)2.40350400
39Gastrointestinal stroma tumor (HP:0100723)2.39779057
40Abnormality of liposaccharide metabolism (HP:0010968)2.31887692
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.31887692
42Abnormality of glycolipid metabolism (HP:0010969)2.31887692
43B lymphocytopenia (HP:0010976)2.31763122
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30911532
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30911532
46Abnormality of polysaccharide metabolism (HP:0011012)2.30911532
47Chromsome breakage (HP:0040012)2.28541306
48Acute encephalopathy (HP:0006846)2.28170406
49Neoplasm of the peripheral nervous system (HP:0100007)2.27106199
50Recurrent bronchitis (HP:0002837)2.26288034
51Gaze-evoked nystagmus (HP:0000640)2.22923224
52Increased density of long bones (HP:0006392)2.19181597
53Impaired proprioception (HP:0010831)2.19064055
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16882127
55Abnormal protein N-linked glycosylation (HP:0012347)2.16882127
56Abnormal protein glycosylation (HP:0012346)2.16882127
57Abnormal glycosylation (HP:0012345)2.16882127
58Tubular atrophy (HP:0000092)2.16617039
59Hyperammonemia (HP:0001987)2.12906012
60Abolished electroretinogram (ERG) (HP:0000550)2.12029798
61Chorioretinal atrophy (HP:0000533)2.09593395
62Abnormality of T cell physiology (HP:0011840)2.08997225
63Germ cell neoplasia (HP:0100728)2.07551666
64Abnormality of oral frenula (HP:0000190)2.07312723
65Orchitis (HP:0100796)2.07100073
66Clitoromegaly (HP:0000057)2.06839879
67Abnormal respiratory motile cilium morphology (HP:0005938)2.06737958
68Abnormal respiratory epithelium morphology (HP:0012253)2.06737958
69Limb ataxia (HP:0002070)2.06644254
70Abnormality of B cell number (HP:0010975)2.06348493
71Bilateral sensorineural hearing impairment (HP:0008619)2.03531590
72Dysostosis multiplex (HP:0000943)2.02183650
73Duplicated collecting system (HP:0000081)1.99394893
74Poor head control (HP:0002421)1.99001658
75Absent/shortened dynein arms (HP:0200106)1.98975648
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.98975648
77Horseshoe kidney (HP:0000085)1.98879428
78Bronchitis (HP:0012387)1.98834228
79Supernumerary bones of the axial skeleton (HP:0009144)1.98287353
80Aplasia/hypoplasia of the uterus (HP:0008684)1.97526106
81Abnormal hair laboratory examination (HP:0003328)1.95708731
82Arterial thrombosis (HP:0004420)1.95124850
83Abnormal ciliary motility (HP:0012262)1.93022240
84Abnormality of the prostate (HP:0008775)1.93009843
85Vertigo (HP:0002321)1.91852408
86Abnormality of the renal collecting system (HP:0004742)1.91658296
87Nephronophthisis (HP:0000090)1.89424128
88Micronodular cirrhosis (HP:0001413)1.87467439
89Hypergonadotropic hypogonadism (HP:0000815)1.87272907
90Urinary glycosaminoglycan excretion (HP:0003541)1.84864017
91Mucopolysacchariduria (HP:0008155)1.84864017
92Hypoplasia of the uterus (HP:0000013)1.84496736
93Anorexia (HP:0002039)1.83200650
94Abnormality of the pons (HP:0007361)1.83080764
95Amelogenesis imperfecta (HP:0000705)1.82750516
96Abnormal respiratory motile cilium physiology (HP:0012261)1.81659904
97Thyroiditis (HP:0100646)1.81601415
98Hypophosphatemia (HP:0002148)1.80003672
99Gonadal dysgenesis (HP:0000133)1.79445630
100Abnormality of the umbilical cord (HP:0010881)1.78275493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.36089310
2MUSK5.12656216
3MATK4.03842846
4MAPKAPK33.68243859
5FES3.15011072
6TXK2.99301892
7GRK62.94834832
8MAP3K112.45797483
9TAOK12.33096109
10NTRK12.19372396
11MST42.12394385
12TAOK21.96066581
13MAP2K21.93215396
14MAP3K141.90268573
15VRK21.78353477
16NEK61.77632359
17PIK3CA1.65761585
18MARK31.63857232
19MAP3K31.51163579
20KIT1.49478928
21IRAK31.44168886
22PINK11.43165072
23FER1.38929574
24CSK1.29913234
25RPS6KB21.29497177
26TLK11.29038513
27IKBKB1.26661294
28SIK31.23481883
29TIE11.20779248
30TBK11.15687174
31BMPR21.15159600
32MAP3K121.13240351
33IKBKE1.11659048
34PHKG21.08031016
35PHKG11.08031016
36NUAK11.05320276
37EIF2AK21.04318397
38GRK11.03512272
39STK101.03228719
40TESK21.01197491
41ALK1.00890616
42ZAK0.99172885
43NLK0.97963024
44OXSR10.89755192
45EIF2AK10.88917305
46MAP4K10.88775384
47KDR0.77040845
48EPHA20.76214760
49NEK10.74468138
50MAP4K20.70923982
51SIK10.68864688
52PRKD20.68574455
53CSNK1G30.68197984
54JAK10.66924882
55WNK40.65879227
56LMTK20.64374229
57CHUK0.62034899
58DAPK10.60685966
59MAPKAPK20.59866377
60LCK0.56225248
61CHEK20.56074659
62CSNK1A1L0.56071308
63SMG10.50942045
64ADRBK20.48848075
65ILK0.46535002
66MAP2K30.46091273
67MAP3K10.43064413
68FRK0.42556846
69CDK30.41907325
70SRPK10.40782193
71MAP3K50.40300573
72PRKCQ0.38956537
73TYRO30.38884675
74INSR0.38337238
75PRKCI0.37127211
76CDK70.36589125
77CDK190.35153109
78JAK30.32574817
79CSNK1G20.32027374
80ERBB30.30326505
81MAP3K70.29624531
82CDK40.29391220
83ARAF0.27260047
84ERBB20.27200522
85STK390.26596257
86IGF1R0.26369946
87CSNK1G10.26073924
88TESK10.25298892
89FGR0.24729677
90MAP2K10.24354917
91LYN0.23475444
92PIM10.22599327
93VRK10.21220553
94PDK10.20871021
95FYN0.20819258
96CSNK1D0.18179521
97ADRBK10.17580787
98RPS6KA10.16821283
99MYLK0.16330091
100TTK0.16163446

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.65389139
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.09650508
3One carbon pool by folate_Homo sapiens_hsa006702.87832904
4Primary immunodeficiency_Homo sapiens_hsa053402.74785706
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59965684
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50209305
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.48913622
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.45740024
9Chemical carcinogenesis_Homo sapiens_hsa052042.26794638
10RNA polymerase_Homo sapiens_hsa030202.15857759
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.12813026
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95200398
13Thyroid cancer_Homo sapiens_hsa052161.89204891
14Basal transcription factors_Homo sapiens_hsa030221.87799905
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.87352083
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.83576871
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79853361
18Phenylalanine metabolism_Homo sapiens_hsa003601.77669980
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77018865
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73411150
21Arachidonic acid metabolism_Homo sapiens_hsa005901.68340628
22Tryptophan metabolism_Homo sapiens_hsa003801.64751667
23Caffeine metabolism_Homo sapiens_hsa002321.60358697
24Regulation of autophagy_Homo sapiens_hsa041401.55469494
25T cell receptor signaling pathway_Homo sapiens_hsa046601.51383791
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49005630
27Fatty acid elongation_Homo sapiens_hsa000621.48900669
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.47534029
29N-Glycan biosynthesis_Homo sapiens_hsa005101.45924255
30Pyrimidine metabolism_Homo sapiens_hsa002401.42205857
31Nucleotide excision repair_Homo sapiens_hsa034201.37336189
32Base excision repair_Homo sapiens_hsa034101.29140438
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.26027739
34Malaria_Homo sapiens_hsa051441.21307442
35Purine metabolism_Homo sapiens_hsa002301.17731125
36Acute myeloid leukemia_Homo sapiens_hsa052211.16544130
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12456201
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08810383
39Apoptosis_Homo sapiens_hsa042101.07709627
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05351852
41Tyrosine metabolism_Homo sapiens_hsa003501.04342872
42Selenocompound metabolism_Homo sapiens_hsa004501.02689978
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01714390
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.99717840
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.98432675
46Linoleic acid metabolism_Homo sapiens_hsa005910.97145936
47Renal cell carcinoma_Homo sapiens_hsa052110.96222650
48Nitrogen metabolism_Homo sapiens_hsa009100.96140577
49Lysosome_Homo sapiens_hsa041420.96075174
50Homologous recombination_Homo sapiens_hsa034400.93603045
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91197327
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89235787
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.88455378
54Phototransduction_Homo sapiens_hsa047440.87252825
55Sphingolipid metabolism_Homo sapiens_hsa006000.82911567
56Ether lipid metabolism_Homo sapiens_hsa005650.82666758
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.79755966
58Graft-versus-host disease_Homo sapiens_hsa053320.79208139
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77738238
60Proteasome_Homo sapiens_hsa030500.76478761
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75475934
62Herpes simplex infection_Homo sapiens_hsa051680.74621946
63Retinol metabolism_Homo sapiens_hsa008300.63605384
64Fanconi anemia pathway_Homo sapiens_hsa034600.60903448
65Propanoate metabolism_Homo sapiens_hsa006400.59835118
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.59040576
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59034455
68TNF signaling pathway_Homo sapiens_hsa046680.56331887
69Ribosome_Homo sapiens_hsa030100.56037150
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55890689
71Mineral absorption_Homo sapiens_hsa049780.54987802
72Fat digestion and absorption_Homo sapiens_hsa049750.54473761
73RNA degradation_Homo sapiens_hsa030180.52655165
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49208224
75Endocytosis_Homo sapiens_hsa041440.48241362
76beta-Alanine metabolism_Homo sapiens_hsa004100.47928654
77Spliceosome_Homo sapiens_hsa030400.45691443
78Peroxisome_Homo sapiens_hsa041460.45446453
79Metabolic pathways_Homo sapiens_hsa011000.44929215
80Chemokine signaling pathway_Homo sapiens_hsa040620.43934201
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41296745
82Other glycan degradation_Homo sapiens_hsa005110.38446579
83Measles_Homo sapiens_hsa051620.37178721
84Starch and sucrose metabolism_Homo sapiens_hsa005000.35136165
85MAPK signaling pathway_Homo sapiens_hsa040100.33560861
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32155263
87Non-homologous end-joining_Homo sapiens_hsa034500.31904955
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30507875
89Viral carcinogenesis_Homo sapiens_hsa052030.29949184
90Autoimmune thyroid disease_Homo sapiens_hsa053200.29189012
91Glutathione metabolism_Homo sapiens_hsa004800.26026013
92Vitamin digestion and absorption_Homo sapiens_hsa049770.25436108
93Ovarian steroidogenesis_Homo sapiens_hsa049130.24375852
94B cell receptor signaling pathway_Homo sapiens_hsa046620.23092587
95Legionellosis_Homo sapiens_hsa051340.22519278
96Fatty acid metabolism_Homo sapiens_hsa012120.19118973
97Renin-angiotensin system_Homo sapiens_hsa046140.19094426
98Circadian rhythm_Homo sapiens_hsa047100.19018455
99Oxidative phosphorylation_Homo sapiens_hsa001900.18244451
100HIF-1 signaling pathway_Homo sapiens_hsa040660.16692268

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