ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	otic vesicle formation (GO:0030916)	9.29141385
2	chaperone-mediated protein transport (GO:0072321)	7.58345262
3	artery smooth muscle contraction (GO:0014824)	7.00525710
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.95846167
5	tonic smooth muscle contraction (GO:0014820)	5.96320667
6	peptidyl-histidine modification (GO:0018202)	5.43173275
7	inner mitochondrial membrane organization (GO:0007007)	5.38318233
8	ribosomal small subunit assembly (GO:0000028)	5.36313425
9	regulation of mitochondrial translation (GO:0070129)	4.92927371
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.71567238
11	maturation of SSU-rRNA (GO:0030490)	4.66993926
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.62550512
13	ATP synthesis coupled proton transport (GO:0015986)	4.62550512
14	intestinal epithelial cell development (GO:0060576)	4.53131184
15	phasic smooth muscle contraction (GO:0014821)	4.24949063
16	proteasome assembly (GO:0043248)	4.14349431
17	primary alcohol catabolic process (GO:0034310)	4.07699350
18	regulation of mitotic spindle checkpoint (GO:1903504)	4.05484321
19	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.05484321
20	respiratory electron transport chain (GO:0022904)	4.04933294
21	forebrain morphogenesis (GO:0048853)	4.01008050
22	electron transport chain (GO:0022900)	3.94178100
23	daunorubicin metabolic process (GO:0044597)	3.88940763
24	polyketide metabolic process (GO:0030638)	3.88940763
25	doxorubicin metabolic process (GO:0044598)	3.88940763
26	prostaglandin biosynthetic process (GO:0001516)	3.87587461
27	prostanoid biosynthetic process (GO:0046457)	3.87587461
28	vascular smooth muscle contraction (GO:0014829)	3.80975531
29	ribosomal large subunit biogenesis (GO:0042273)	3.69666478
30	translational termination (GO:0006415)	3.69630204
31	GDP-mannose metabolic process (GO:0019673)	3.68415523
32	viral transcription (GO:0019083)	3.66709738
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57697958
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57697958
35	NADH dehydrogenase complex assembly (GO:0010257)	3.57697958
36	energy homeostasis (GO:0097009)	3.56333177
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.55126917
38	synaptonemal complex assembly (GO:0007130)	3.55030976
39	protein complex biogenesis (GO:0070271)	3.45609761
40	aminoglycoside antibiotic metabolic process (GO:0030647)	3.45556053
41	protein maturation by protein folding (GO:0022417)	3.42499350
42	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.39785524
43	pseudouridine synthesis (GO:0001522)	3.36681996
44	membrane budding (GO:0006900)	3.36528276
45	serotonin receptor signaling pathway (GO:0007210)	3.35720559
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.32160044
47	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.30609752
48	termination of RNA polymerase III transcription (GO:0006386)	3.29947596
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.29947596
50	vasoconstriction (GO:0042310)	3.29902565
51	negative regulation of telomerase activity (GO:0051974)	3.17614951
52	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.14789625
53	cotranslational protein targeting to membrane (GO:0006613)	3.11865385
54	translational elongation (GO:0006414)	3.10704503
55	quinone metabolic process (GO:1901661)	3.10095952
56	rRNA modification (GO:0000154)	3.09330567
57	prostaglandin metabolic process (GO:0006693)	3.06295009
58	prostanoid metabolic process (GO:0006692)	3.06295009
59	protein-cofactor linkage (GO:0018065)	3.05931538
60	synaptonemal complex organization (GO:0070193)	3.04904212
61	paraxial mesoderm development (GO:0048339)	3.04799072
62	protein targeting to ER (GO:0045047)	3.03898758
63	ethanol oxidation (GO:0006069)	3.02988011
64	peroxisome fission (GO:0016559)	3.00963331
65	protein localization to endoplasmic reticulum (GO:0070972)	2.98870196
66	cellular glucuronidation (GO:0052695)	2.97951182
67	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.97940212
68	intracellular protein transmembrane import (GO:0044743)	2.97329681
69	outer ear morphogenesis (GO:0042473)	2.95782045
70	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.93876716
71	regulation of cellular amino acid metabolic process (GO:0006521)	2.93524493
72	viral life cycle (GO:0019058)	2.93305500
73	glucuronate metabolic process (GO:0019585)	2.93080846
74	uronic acid metabolic process (GO:0006063)	2.93080846
75	negative regulation of ligase activity (GO:0051352)	2.91645917
76	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.91645917
77	hydrogen ion transmembrane transport (GO:1902600)	2.91213953
78	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.91075594
79	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.90276383
80	mitochondrial RNA metabolic process (GO:0000959)	2.89210985
81	translational initiation (GO:0006413)	2.86950047
82	ribosomal small subunit biogenesis (GO:0042274)	2.86519390
83	cellular protein complex disassembly (GO:0043624)	2.85418968
84	ethanol metabolic process (GO:0006067)	2.84886134
85	nucleoside transmembrane transport (GO:1901642)	2.84276805
86	inositol phosphate-mediated signaling (GO:0048016)	2.84260798
87	cellular component biogenesis (GO:0044085)	2.81326101
88	reciprocal DNA recombination (GO:0035825)	2.80856284
89	reciprocal meiotic recombination (GO:0007131)	2.80856284
90	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.79124461
91	DNA ligation (GO:0006266)	2.72856683
92	rRNA processing (GO:0006364)	2.70147571
93	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.68051371
94	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67436323
95	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67436323
96	response to redox state (GO:0051775)	2.66648706
97	maturation of 5.8S rRNA (GO:0000460)	2.65996199
98	establishment of integrated proviral latency (GO:0075713)	2.65801219
99	regulation of spindle checkpoint (GO:0090231)	2.64289622
100	pteridine-containing compound biosynthetic process (GO:0042559)	2.62803334

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.98129226
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.22941340
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.00815278
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.62120025
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59732012
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.40941694
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.26842532
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.24367749
9	MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.03211739
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.75541000
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.74230650
12	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.72706128
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.69730755
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63100378
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.58886801
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.54529263
17	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.35977633
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.33758574
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.33088986
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.32718225
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.23359398
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21379344
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.12774426
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.10434508
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.06232853
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.99965205
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97777302
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.95949743
29	XRN2_22483619_ChIP-Seq_HELA_Human	1.84774536
30	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.80194708
31	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.80194708
32	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.80194708
33	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.80073899
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.75827316
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.74328336
36	ZNF263_19887448_ChIP-Seq_K562_Human	1.71733627
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69409494
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.69197046
39	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.68222002
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.67448246
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.66169378
42	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.61940199
43	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.56993765
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.55292392
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51672658
46	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.50694298
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.49887055
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43932682
49	AR_21909140_ChIP-Seq_LNCAP_Human	1.41961445
50	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.41599048
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.38289901
52	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.33912271
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.33705471
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33626167
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.33389448
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29498764
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.29356354
58	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.28000572
59	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.26220926
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24432092
61	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.24305855
62	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.23662064
63	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.22300374
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21241692
65	ELF5_23300383_ChIP-Seq_T47D_Human	1.20447213
66	EOMES_21245162_ChIP-Seq_HESCs_Human	1.20288038
67	NANOG_18692474_ChIP-Seq_MEFs_Mouse	1.18709720
68	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.16254021
69	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16235731
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.15998277
71	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.14448367
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13435589
73	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.12491077
74	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.12125124
75	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.11022330
76	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.10793642
77	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.10395342
78	GATA4_25053715_ChIP-Seq_YYC3_Human	1.08425342
79	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.08217067
80	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.04937720
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03956974
82	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00733755
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.00389641
84	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.99646225
85	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.98874968
86	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.98611939
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97903368
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96152274
89	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95787471
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93677735
91	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93076626
92	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.92921628
93	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.92787832
94	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.89069856
95	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88952813
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.88758244
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88243977
98	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.87977179
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.87576537
100	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.86880233

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	9.33193193
2	MP0003136_yellow_coat_color	6.67468333
3	MP0002277_abnormal_respiratory_mucosa	5.38162421
4	MP0001293_anophthalmia	2.98265270
5	MP0003693_abnormal_embryo_hatching	2.39512292
6	MP0000372_irregular_coat_pigmentation	2.35241630
7	MP0001485_abnormal_pinna_reflex	2.32356679
8	MP0003011_delayed_dark_adaptation	2.25537786
9	MP0009379_abnormal_foot_pigmentation	2.21161074
10	MP0003938_abnormal_ear_development	2.21152567
11	MP0000647_abnormal_sebaceous_gland	2.12517275
12	MP0001299_abnormal_eye_distance/	2.06085313
13	MP0001666_abnormal_nutrient_absorption	2.05871893
14	MP0003878_abnormal_ear_physiology	2.05131568
15	MP0005377_hearing/vestibular/ear_phenot	2.05131568
16	MP0002132_abnormal_respiratory_system	1.90652190
17	MP0004264_abnormal_extraembryonic_tissu	1.89883925
18	MP0004957_abnormal_blastocyst_morpholog	1.86187811
19	MP0004019_abnormal_vitamin_homeostasis	1.83994616
20	MP0003186_abnormal_redox_activity	1.77015302
21	MP0002163_abnormal_gland_morphology	1.73351445
22	MP0006035_abnormal_mitochondrial_morpho	1.72749411
23	MP0004381_abnormal_hair_follicle	1.63443012
24	MP0001529_abnormal_vocalization	1.46334503
25	MP0003077_abnormal_cell_cycle	1.40115918
26	MP0003880_abnormal_central_pattern	1.37831485
27	MP0002736_abnormal_nociception_after	1.37356964
28	MP0002233_abnormal_nose_morphology	1.37343574
29	MP0002254_reproductive_system_inflammat	1.37218437
30	MP0003567_abnormal_fetal_cardiomyocyte	1.34504732
31	MP0004885_abnormal_endolymph	1.34397453
32	MP0002796_impaired_skin_barrier	1.25432314
33	MP0005058_abnormal_lysosome_morphology	1.24383226
34	MP0003806_abnormal_nucleotide_metabolis	1.17723196
35	MP0008872_abnormal_physiological_respon	1.16370401
36	MP0009840_abnormal_foam_cell	1.16167619
37	MP0005379_endocrine/exocrine_gland_phen	1.16027739
38	MP0002697_abnormal_eye_size	1.12986453
39	MP0003111_abnormal_nucleus_morphology	1.11773331
40	MP0000631_abnormal_neuroendocrine_gland	1.10419639
41	MP0002090_abnormal_vision	1.10128286
42	MP0005365_abnormal_bile_salt	1.09576476
43	MP0001286_abnormal_eye_development	1.07805885
44	MP0005187_abnormal_penis_morphology	1.06544037
45	MP0000358_abnormal_cell_content/	1.05994671
46	MP0006036_abnormal_mitochondrial_physio	1.01064153
47	MP0003718_maternal_effect	1.00997905
48	MP0010094_abnormal_chromosome_stability	0.99242925
49	MP0005075_abnormal_melanosome_morpholog	0.98806017
50	MP0002092_abnormal_eye_morphology	0.94452173
51	MP0005332_abnormal_amino_acid	0.92262744
52	MP0005670_abnormal_white_adipose	0.90562612
53	MP0002653_abnormal_ependyma_morphology	0.89794390
54	MP0000467_abnormal_esophagus_morphology	0.89188348
55	MP0008875_abnormal_xenobiotic_pharmacok	0.87798851
56	MP0001986_abnormal_taste_sensitivity	0.82703136
57	MP0005085_abnormal_gallbladder_physiolo	0.81516594
58	MP0008932_abnormal_embryonic_tissue	0.80975851
59	MP0000428_abnormal_craniofacial_morphol	0.80935969
60	MP0000613_abnormal_salivary_gland	0.80484649
61	MP0000490_abnormal_crypts_of	0.80006268
62	MP0001672_abnormal_embryogenesis/_devel	0.79898123
63	MP0005380_embryogenesis_phenotype	0.79898123
64	MP0003195_calcinosis	0.77880264
65	MP0001663_abnormal_digestive_system	0.75292172
66	MP0005636_abnormal_mineral_homeostasis	0.75094053
67	MP0001968_abnormal_touch/_nociception	0.72751994
68	MP0005381_digestive/alimentary_phenotyp	0.72204200
69	MP0004147_increased_porphyrin_level	0.71538586
70	MP0002139_abnormal_hepatobiliary_system	0.71424161
71	MP0002938_white_spotting	0.71351050
72	MP0002210_abnormal_sex_determination	0.70724621
73	MP0008057_abnormal_DNA_replication	0.70434403
74	MP0002085_abnormal_embryonic_tissue	0.69576410
75	MP0008775_abnormal_heart_ventricle	0.68199936
76	MP0000462_abnormal_digestive_system	0.68173014
77	MP0003890_abnormal_embryonic-extraembry	0.67939820
78	MP0006072_abnormal_retinal_apoptosis	0.66622414
79	MP0002102_abnormal_ear_morphology	0.66293866
80	MP0001764_abnormal_homeostasis	0.66122853
81	MP0010352_gastrointestinal_tract_polyps	0.65898128
82	MP0010030_abnormal_orbit_morphology	0.65122004
83	MP0009697_abnormal_copulation	0.65011626
84	MP0005391_vision/eye_phenotype	0.64061410
85	MP0001873_stomach_inflammation	0.62322981
86	MP0003786_premature_aging	0.61934490
87	MP0010386_abnormal_urinary_bladder	0.61670674
88	MP0003566_abnormal_cell_adhesion	0.60757220
89	MP0001849_ear_inflammation	0.59810290
90	MP0005330_cardiomyopathy	0.58629120
91	MP0002088_abnormal_embryonic_growth/wei	0.58235563
92	MP0008058_abnormal_DNA_repair	0.57963201
93	MP0003984_embryonic_growth_retardation	0.57470960
94	MP0001346_abnormal_lacrimal_gland	0.56527762
95	MP0002060_abnormal_skin_morphology	0.56422977
96	MP0003941_abnormal_skin_development	0.56019033
97	MP0000653_abnormal_sex_gland	0.55958712
98	MP0005266_abnormal_metabolism	0.55569890
99	MP0010771_integument_phenotype	0.53653928
100	MP0008004_abnormal_stomach_pH	0.53653877

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	9.85796120
2	Maternal diabetes (HP:0009800)	6.00634827
3	Optic nerve hypoplasia (HP:0000609)	5.71781976
4	Absent septum pellucidum (HP:0001331)	5.35701956
5	Abnormality of the septum pellucidum (HP:0007375)	4.98297136
6	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	4.97718552
7	Acute necrotizing encephalopathy (HP:0006965)	3.74720824
8	Generalized aminoaciduria (HP:0002909)	3.67438899
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.63057302
10	Hepatic necrosis (HP:0002605)	3.54171303
11	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	3.48783664
12	Acute encephalopathy (HP:0006846)	3.41770324
13	Concave nail (HP:0001598)	3.41003945
14	Hypoglycemic coma (HP:0001325)	3.25718652
15	Hepatocellular necrosis (HP:0001404)	3.21382334
16	Progressive macrocephaly (HP:0004481)	3.10731053
17	Mitochondrial inheritance (HP:0001427)	3.06822916
18	Hydroxyprolinuria (HP:0003080)	3.04470427
19	Abnormality of proline metabolism (HP:0010907)	3.04470427
20	Increased CSF lactate (HP:0002490)	2.87248926
21	Cerebral edema (HP:0002181)	2.86972714
22	Abnormal number of erythroid precursors (HP:0012131)	2.71007825
23	Primary adrenal insufficiency (HP:0008207)	2.69975927
24	Rectovaginal fistula (HP:0000143)	2.64309803
25	Rectal fistula (HP:0100590)	2.64309803
26	Breast aplasia (HP:0100783)	2.63369192
27	Abnormality of cells of the erythroid lineage (HP:0012130)	2.62519842
28	Stenosis of the external auditory canal (HP:0000402)	2.57107127
29	Prenatal maternal abnormality (HP:0002686)	2.56092637
30	Amelogenesis imperfecta (HP:0000705)	2.54970558
31	Vaginal fistula (HP:0004320)	2.41763182
32	Absent eyebrow (HP:0002223)	2.41244234
33	Aplasia/Hypoplasia of the breasts (HP:0010311)	2.40689302
34	Septate vagina (HP:0001153)	2.39046534
35	Sparse eyelashes (HP:0000653)	2.36943656
36	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.36389247
37	Reduced antithrombin III activity (HP:0001976)	2.32819009
38	Abnormal number of incisors (HP:0011064)	2.32581396
39	Bilateral microphthalmos (HP:0007633)	2.32493654
40	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.32356445
41	Partial duplication of thumb phalanx (HP:0009944)	2.30318890
42	Hypoplasia of the pons (HP:0012110)	2.29595445
43	Villous atrophy (HP:0011473)	2.28187215
44	Abnormality of small intestinal villus morphology (HP:0011472)	2.28187215
45	Oral leukoplakia (HP:0002745)	2.21116100
46	Sensory axonal neuropathy (HP:0003390)	2.16852769
47	Growth hormone deficiency (HP:0000824)	2.14817730
48	Type I transferrin isoform profile (HP:0003642)	2.14764422
49	Respiratory difficulties (HP:0002880)	2.13516020
50	Optic disc pallor (HP:0000543)	2.08782690
51	Type II lissencephaly (HP:0007260)	2.08074263
52	Erectile abnormalities (HP:0100639)	2.07937705
53	Macrocytic anemia (HP:0001972)	2.06615539
54	Hypohidrosis (HP:0000966)	2.06208992
55	Pendular nystagmus (HP:0012043)	2.06023202
56	Abnormality of the pons (HP:0007361)	2.05405295
57	Intestinal fistula (HP:0100819)	2.04665477
58	Increased serum lactate (HP:0002151)	2.02940346
59	Testicular atrophy (HP:0000029)	2.02582254
60	Proximal tubulopathy (HP:0000114)	2.02301780
61	Median cleft lip (HP:0000161)	1.97715354
62	Increased serum pyruvate (HP:0003542)	1.96155761
63	Nausea (HP:0002018)	1.93312736
64	Reticulocytopenia (HP:0001896)	1.91128481
65	Partial duplication of the phalanx of hand (HP:0009999)	1.89655951
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.89437965
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.89437965
68	Lactic acidosis (HP:0003128)	1.89045852
69	Rough bone trabeculation (HP:0100670)	1.88571253
70	Tracheoesophageal fistula (HP:0002575)	1.85811399
71	Lethargy (HP:0001254)	1.84641464
72	Adrenal hypoplasia (HP:0000835)	1.84524021
73	Lipid accumulation in hepatocytes (HP:0006561)	1.82538386
74	Abnormality of fatty-acid metabolism (HP:0004359)	1.81775074
75	Right ventricular cardiomyopathy (HP:0011663)	1.81542904
76	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.81005995
77	Abnormality of placental membranes (HP:0011409)	1.80982473
78	Amniotic constriction ring (HP:0009775)	1.80982473
79	Microretrognathia (HP:0000308)	1.80876050
80	Renal cortical cysts (HP:0000803)	1.78870720
81	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78020263
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.78020263
83	Abnormal protein glycosylation (HP:0012346)	1.78020263
84	Abnormal glycosylation (HP:0012345)	1.78020263
85	Female pseudohermaphroditism (HP:0010458)	1.77994237
86	Brittle hair (HP:0002299)	1.77592701
87	Abnormality of the parietal bone (HP:0002696)	1.77432613
88	Abnormality of glycolysis (HP:0004366)	1.76409950
89	Truncus arteriosus (HP:0001660)	1.76187941
90	Decreased subcutaneous fat (HP:0001002)	1.73018185
91	Vascular calcification (HP:0004934)	1.72028004
92	Increased hepatocellular lipid droplets (HP:0006565)	1.71584988
93	Poor suck (HP:0002033)	1.71409582
94	Pili torti (HP:0003777)	1.71362241
95	Prolonged partial thromboplastin time (HP:0003645)	1.70475003
96	Congenital, generalized hypertrichosis (HP:0004540)	1.69666808
97	Leukodystrophy (HP:0002415)	1.69323128
98	Abnormal trabecular bone morphology (HP:0100671)	1.69079766
99	Gynecomastia (HP:0000771)	1.68541681
100	Abolished electroretinogram (ERG) (HP:0000550)	1.65266339

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	5.03790876
2	EPHA4	4.86737031
3	CASK	4.25846881
4	SRPK1	3.65287491
5	EPHA2	3.34123743
6	STK39	3.13502840
7	MST4	2.66321779
8	TRIM28	2.57902182
9	TAF1	2.48842546
10	OXSR1	2.46144683
11	BUB1	2.41822501
12	PDK2	2.23673894
13	WNK4	2.20574573
14	NEK1	2.05726089
15	TNIK	1.90568596
16	LATS1	1.80540981
17	RPS6KB2	1.80035829
18	VRK2	1.78639509
19	LIMK1	1.77858220
20	TESK1	1.59013010
21	PLK4	1.56422556
22	GRK1	1.56316591
23	TLK1	1.45259406
24	BCKDK	1.44767743
25	NME2	1.34948371
26	TTK	1.33343474
27	MAPKAPK3	1.17975715
28	PAK4	1.17285630
29	MAP3K12	1.14738269
30	ZAK	1.13239473
31	ABL2	1.10731003
32	DAPK1	1.06490045
33	MST1R	1.02750095
34	STK16	0.94855560
35	GRK6	0.94797791
36	NME1	0.93710074
37	NEK2	0.89276321
38	ERBB4	0.89154594
39	ILK	0.88034546
40	EIF2AK3	0.85897766
41	NUAK1	0.85771906
42	PRKG2	0.83731980
43	AURKB	0.82902401
44	STK4	0.82507442
45	PRKCI	0.80639505
46	PRKCE	0.80601022
47	WEE1	0.78759694
48	AURKA	0.78528355
49	FGFR1	0.77928248
50	TBK1	0.75621189
51	EIF2AK1	0.74497899
52	CHEK2	0.73989122
53	MAP2K6	0.73698417
54	MYLK	0.71607370
55	TSSK6	0.71276576
56	STK38L	0.71151181
57	PLK1	0.68780991
58	LATS2	0.64574475
59	NTRK3	0.64564303
60	WNK3	0.63754154
61	CDC7	0.63743523
62	MUSK	0.62510656
63	DYRK2	0.60489057
64	CSNK2A1	0.58033437
65	LMTK2	0.57180686
66	CSNK2A2	0.56604929
67	CAMK2G	0.47486702
68	MATK	0.46999801
69	ALK	0.45742930
70	CAMK2B	0.45725919
71	MKNK1	0.45193252
72	MAP2K4	0.45139681
73	DAPK3	0.44868382
74	MKNK2	0.43316625
75	MAP2K1	0.43198373
76	BMX	0.42190776
77	PLK3	0.41722077
78	CSNK1A1	0.41573047
79	TESK2	0.41288846
80	PTK2	0.41184317
81	KDR	0.40674084
82	TRPM7	0.37182428
83	EPHB2	0.36934703
84	CSNK1E	0.36725711
85	PINK1	0.35722565
86	BRSK2	0.33601151
87	MAPK12	0.32259453
88	CDK7	0.31438741
89	BMPR1B	0.30926980
90	CAMK2D	0.28556822
91	AKT2	0.25431191
92	VRK1	0.24692476
93	EGFR	0.24524447
94	PIM2	0.24433882
95	PAK1	0.23927658
96	CDK9	0.23047853
97	MET	0.22041681
98	EPHB1	0.21779858
99	IRAK4	0.21700787
100	PRKCA	0.21424722

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.78572795
2	Ribosome_Homo sapiens_hsa03010	3.73456381
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.68228407
4	Parkinsons disease_Homo sapiens_hsa05012	3.03214881
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.84184827
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.68597679
7	Huntingtons disease_Homo sapiens_hsa05016	2.28329721
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.22469037
9	Alzheimers disease_Homo sapiens_hsa05010	2.04129215
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.98660852
11	Mismatch repair_Homo sapiens_hsa03430	1.95966368
12	Homologous recombination_Homo sapiens_hsa03440	1.95413755
13	Folate biosynthesis_Homo sapiens_hsa00790	1.93486639
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.84874883
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.80210768
16	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.76333749
17	Retinol metabolism_Homo sapiens_hsa00830	1.67456803
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.63786865
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59921177
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.59130019
21	DNA replication_Homo sapiens_hsa03030	1.58287641
22	RNA polymerase_Homo sapiens_hsa03020	1.55095723
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.54982393
24	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.54522618
25	Base excision repair_Homo sapiens_hsa03410	1.50417922
26	Sulfur metabolism_Homo sapiens_hsa00920	1.49630059
27	Basal transcription factors_Homo sapiens_hsa03022	1.46666715
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45410200
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.40080279
30	Glutathione metabolism_Homo sapiens_hsa00480	1.38552327
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31547905
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.28181048
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27437993
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26663419
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26119052
36	Protein digestion and absorption_Homo sapiens_hsa04974	1.24277091
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23259095
38	Pancreatic secretion_Homo sapiens_hsa04972	1.22397533
39	Tyrosine metabolism_Homo sapiens_hsa00350	1.20739203
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.18608816
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.17416636
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.17261215
43	Spliceosome_Homo sapiens_hsa03040	1.07940446
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.07769830
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.07348280
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06249748
47	RNA transport_Homo sapiens_hsa03013	1.05759774
48	Pyruvate metabolism_Homo sapiens_hsa00620	1.04841174
49	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04554362
50	Propanoate metabolism_Homo sapiens_hsa00640	1.00989267
51	Renin-angiotensin system_Homo sapiens_hsa04614	0.96581082
52	Fatty acid degradation_Homo sapiens_hsa00071	0.96456074
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94284328
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.92873581
55	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.90886435
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90619811
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.90134657
58	Fatty acid elongation_Homo sapiens_hsa00062	0.90108106
59	Metabolic pathways_Homo sapiens_hsa01100	0.89865516
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89719868
61	Carbon metabolism_Homo sapiens_hsa01200	0.88585754
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86616803
63	Galactose metabolism_Homo sapiens_hsa00052	0.86196183
64	Peroxisome_Homo sapiens_hsa04146	0.85667204
65	RNA degradation_Homo sapiens_hsa03018	0.84632595
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.83932262
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80359349
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.72645004
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72331156
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71494385
71	Tight junction_Homo sapiens_hsa04530	0.70015435
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67656210
73	Purine metabolism_Homo sapiens_hsa00230	0.67600843
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63480588
75	Arginine biosynthesis_Homo sapiens_hsa00220	0.62573717
76	Histidine metabolism_Homo sapiens_hsa00340	0.61337429
77	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.59264287
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56547442
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.55941214
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.55141044
81	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.48266071
82	Cell cycle_Homo sapiens_hsa04110	0.46619517
83	Sulfur relay system_Homo sapiens_hsa04122	0.46489523
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45681849
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.43735106
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.43193915
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41265609
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40190648
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.39737325
90	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.39188109
91	One carbon pool by folate_Homo sapiens_hsa00670	0.37988882
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37356635
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36342663
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34833141
95	Taste transduction_Homo sapiens_hsa04742	0.33362917
96	Protein export_Homo sapiens_hsa03060	0.24809935
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.24066151
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23322090
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.23154343
100	Thyroid cancer_Homo sapiens_hsa05216	0.21616347

KRT8P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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