ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.62958159
2	glucuronate metabolic process (GO:0019585)	4.48798255
3	uronic acid metabolic process (GO:0006063)	4.48798255
4	cellular glucuronidation (GO:0052695)	4.47948822
5	response to food (GO:0032094)	4.28102994
6	desmosome organization (GO:0002934)	4.21187424
7	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.00238970
8	intestinal absorption (GO:0050892)	3.88977943
9	daunorubicin metabolic process (GO:0044597)	3.81783614
10	polyketide metabolic process (GO:0030638)	3.81783614
11	doxorubicin metabolic process (GO:0044598)	3.81783614
12	flavonoid metabolic process (GO:0009812)	3.74031897
13	GDP-mannose metabolic process (GO:0019673)	3.67914225
14	nucleotide-sugar biosynthetic process (GO:0009226)	3.60752987
15	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.57710945
16	sulfur amino acid catabolic process (GO:0000098)	3.53384229
17	NADH metabolic process (GO:0006734)	3.50968669
18	phenylpropanoid metabolic process (GO:0009698)	3.47924009
19	cysteine metabolic process (GO:0006534)	3.47234366
20	vitamin transmembrane transport (GO:0035461)	3.36876845
21	regulation of guanylate cyclase activity (GO:0031282)	3.36373823
22	aminoglycoside antibiotic metabolic process (GO:0030647)	3.34339033
23	growth hormone secretion (GO:0030252)	3.31352412
24	quinone biosynthetic process (GO:1901663)	3.30263721
25	antibacterial humoral response (GO:0019731)	3.24337339
26	epoxygenase P450 pathway (GO:0019373)	3.22742456
27	bile acid and bile salt transport (GO:0015721)	3.15107940
28	homocysteine metabolic process (GO:0050667)	3.14834032
29	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.14756242
30	notochord development (GO:0030903)	3.14477468
31	cobalamin metabolic process (GO:0009235)	3.12656064
32	positive regulation of glycoprotein metabolic process (GO:1903020)	3.11221881
33	regulation of viral release from host cell (GO:1902186)	3.09021787
34	primary alcohol catabolic process (GO:0034310)	3.07195594
35	galactose catabolic process (GO:0019388)	3.00398938
36	respiratory tube development (GO:0030323)	2.98907098
37	ribosome assembly (GO:0042255)	2.98866488
38	formation of translation preinitiation complex (GO:0001731)	2.98001023
39	protein autoprocessing (GO:0016540)	2.97100280
40	antimicrobial humoral response (GO:0019730)	2.96739994
41	lung epithelium development (GO:0060428)	2.96511312
42	proline biosynthetic process (GO:0006561)	2.95640284
43	proline metabolic process (GO:0006560)	2.95300162
44	intestinal epithelial cell development (GO:0060576)	2.94381902
45	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.94360833
46	glucose 6-phosphate metabolic process (GO:0051156)	2.94149373
47	renal system process involved in regulation of blood volume (GO:0001977)	2.93450550
48	urate metabolic process (GO:0046415)	2.92520559
49	quinone metabolic process (GO:1901661)	2.91108578
50	cyclooxygenase pathway (GO:0019371)	2.90593046
51	L-serine metabolic process (GO:0006563)	2.86311880
52	L-phenylalanine metabolic process (GO:0006558)	2.85907165
53	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.85907165
54	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.84439039
55	regulation of cellular respiration (GO:0043457)	2.79609318
56	positive regulation of pseudopodium assembly (GO:0031274)	2.78782040
57	digestion (GO:0007586)	2.77636071
58	serine family amino acid biosynthetic process (GO:0009070)	2.77320787
59	drug transmembrane transport (GO:0006855)	2.76842772
60	proteasome assembly (GO:0043248)	2.75483076
61	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.74837940
62	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.74837940
63	endocrine process (GO:0050886)	2.74837940
64	regulation of cardioblast differentiation (GO:0051890)	2.73659405
65	Golgi transport vesicle coating (GO:0048200)	2.73340817
66	COPI coating of Golgi vesicle (GO:0048205)	2.73340817
67	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.72688972
68	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.72688972
69	lung-associated mesenchyme development (GO:0060484)	2.71763617
70	ubiquinone biosynthetic process (GO:0006744)	2.69643079
71	tight junction assembly (GO:0070830)	2.68751361
72	nuclear envelope reassembly (GO:0031468)	2.67543650
73	mitotic nuclear envelope reassembly (GO:0007084)	2.67543650
74	serine family amino acid metabolic process (GO:0009069)	2.66122607
75	urea cycle (GO:0000050)	2.65916334
76	sperm capacitation (GO:0048240)	2.65801301
77	prostanoid metabolic process (GO:0006692)	2.65417767
78	prostaglandin metabolic process (GO:0006693)	2.65417767
79	glycoside metabolic process (GO:0016137)	2.62433174
80	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.62338818
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.60856616
82	regulation of systemic arterial blood pressure (GO:0003073)	2.58153385
83	prostaglandin biosynthetic process (GO:0001516)	2.56639082
84	prostanoid biosynthetic process (GO:0046457)	2.56639082
85	sulfate transport (GO:0008272)	2.55960429
86	sulfur compound transport (GO:0072348)	2.54691065
87	urea metabolic process (GO:0019627)	2.53032627
88	arginine metabolic process (GO:0006525)	2.51250983
89	tricarboxylic acid cycle (GO:0006099)	2.51193052
90	ribosomal large subunit biogenesis (GO:0042273)	2.47814022
91	cellular response to pH (GO:0071467)	2.47598626
92	tRNA methylation (GO:0030488)	2.45893843
93	vitamin biosynthetic process (GO:0009110)	2.45527653
94	glutathione biosynthetic process (GO:0006750)	2.45261728
95	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.43485319
96	hepatocyte apoptotic process (GO:0097284)	2.42887730
97	sulfate transmembrane transport (GO:1902358)	2.42421832
98	nonribosomal peptide biosynthetic process (GO:0019184)	2.42142556
99	regulation of viral entry into host cell (GO:0046596)	2.42084862
100	phosphate ion transmembrane transport (GO:0035435)	2.41889142

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.88906943
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.66083234
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.57517800
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.55729195
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.52781643
6	ZNF263_19887448_ChIP-Seq_K562_Human	2.51752545
7	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.34196879
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.32403746
9	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.29766347
10	GATA6_25053715_ChIP-Seq_YYC3_Human	2.28408517
11	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.24662902
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.21917660
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21742079
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16965049
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.15149634
16	GATA4_25053715_ChIP-Seq_YYC3_Human	2.10960145
17	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.09286356
18	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.07901316
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05308687
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99183373
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.98108216
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91507122
23	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.85984411
24	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.83454228
25	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.78275148
26	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.76161012
27	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.74133570
28	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.71998499
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.71542436
30	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.70260515
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.67529333
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.66564621
33	AR_21909140_ChIP-Seq_LNCAP_Human	1.65887274
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.65806264
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.65115921
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.64269047
37	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.62308028
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62167610
39	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.61544168
40	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.61468386
41	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59895522
42	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.59107685
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.58152609
44	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57330464
45	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.55958779
46	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52896844
47	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.51857868
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51734011
49	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.50434034
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.48658942
51	SOX2_20726797_ChIP-Seq_SW620_Human	1.47235207
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42280916
53	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.42025959
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.40602582
55	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.40554198
56	ATF3_27146783_Chip-Seq_COLON_Human	1.40176606
57	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.38795072
58	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.34845022
59	TTF2_22483619_ChIP-Seq_HELA_Human	1.33895885
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33019707
61	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.32929684
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.30720335
63	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.28429202
64	P68_20966046_ChIP-Seq_HELA_Human	1.26967157
65	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.26337315
66	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.24382211
67	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.23517333
68	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.23267763
69	ELF5_23300383_ChIP-Seq_T47D_Human	1.22985813
70	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.22695436
71	RACK7_27058665_Chip-Seq_MCF-7_Human	1.21463717
72	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19590625
73	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.18112343
74	E2F1_20622854_ChIP-Seq_HELA_Human	1.17790456
75	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.17781077
76	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.17318168
77	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.16591284
78	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.16220130
79	PHF8_20622854_ChIP-Seq_HELA_Human	1.15015503
80	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.14554861
81	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.12914250
82	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11567456
83	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11251773
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10917428
85	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.09422659
86	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08463688
87	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.06982948
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05893417
89	BCOR_27268052_Chip-Seq_Bcells_Human	1.04692971
90	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.03986094
91	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02744042
92	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00578550
93	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.98364229
94	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.94666247
95	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.92875629
96	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.92475259
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91819193
98	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91612337
99	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91612163
100	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.91483893

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	4.84973183
2	MP0005360_urolithiasis	4.48863696
3	MP0002139_abnormal_hepatobiliary_system	4.35330376
4	MP0002138_abnormal_hepatobiliary_system	4.18651943
5	MP0003693_abnormal_embryo_hatching	3.66919423
6	MP0004264_abnormal_extraembryonic_tissu	3.39575567
7	MP0001666_abnormal_nutrient_absorption	3.08226581
8	MP0002796_impaired_skin_barrier	2.91876895
9	MP0004147_increased_porphyrin_level	2.77798590
10	MP0008875_abnormal_xenobiotic_pharmacok	2.74788579
11	MP0010030_abnormal_orbit_morphology	2.72972347
12	MP0005085_abnormal_gallbladder_physiolo	2.52214624
13	MP0003806_abnormal_nucleotide_metabolis	2.50464889
14	MP0005365_abnormal_bile_salt	2.38145985
15	MP0004957_abnormal_blastocyst_morpholog	2.16022653
16	MP0004019_abnormal_vitamin_homeostasis	2.13389917
17	MP0008872_abnormal_physiological_respon	2.10346575
18	MP0003868_abnormal_feces_composition	2.07010066
19	MP0000537_abnormal_urethra_morphology	2.02517611
20	MP0005451_abnormal_body_composition	2.02252752
21	MP0010352_gastrointestinal_tract_polyps	1.96334972
22	MP0009379_abnormal_foot_pigmentation	1.95248165
23	MP0005501_abnormal_skin_physiology	1.76873385
24	MP0009840_abnormal_foam_cell	1.63933869
25	MP0000490_abnormal_crypts_of	1.63723762
26	MP0009643_abnormal_urine_homeostasis	1.58259224
27	MP0002098_abnormal_vibrissa_morphology	1.54964426
28	MP0004782_abnormal_surfactant_physiolog	1.54652823
29	MP0003866_abnormal_defecation	1.53625589
30	MP0002876_abnormal_thyroid_physiology	1.50303076
31	MP0005332_abnormal_amino_acid	1.50183421
32	MP0004858_abnormal_nervous_system	1.48325881
33	MP0001664_abnormal_digestion	1.41536455
34	MP0000566_synostosis	1.32139277
35	MP0000477_abnormal_intestine_morphology	1.30955281
36	MP0010678_abnormal_skin_adnexa	1.29561571
37	MP0000462_abnormal_digestive_system	1.27707214
38	MP0005636_abnormal_mineral_homeostasis	1.27676919
39	MP0001346_abnormal_lacrimal_gland	1.27494760
40	MP0008932_abnormal_embryonic_tissue	1.22611056
41	MP0001765_abnormal_ion_homeostasis	1.20042985
42	MP0004043_abnormal_pH_regulation	1.14766407
43	MP0001663_abnormal_digestive_system	1.13912506
44	MP0001873_stomach_inflammation	1.13849946
45	MP0005220_abnormal_exocrine_pancreas	1.12768212
46	MP0003119_abnormal_digestive_system	1.11152948
47	MP0000678_abnormal_parathyroid_gland	1.11093838
48	MP0005083_abnormal_biliary_tract	1.11038025
49	MP0001764_abnormal_homeostasis	1.10400035
50	MP0005248_abnormal_Harderian_gland	1.09939818
51	MP0005381_digestive/alimentary_phenotyp	1.06429872
52	MP0001727_abnormal_embryo_implantation	1.00545538
53	MP0003566_abnormal_cell_adhesion	0.99732446
54	MP0010094_abnormal_chromosome_stability	0.98155129
55	MP0005075_abnormal_melanosome_morpholog	0.98067149
56	MP0001730_embryonic_growth_arrest	0.96924153
57	MP0001216_abnormal_epidermal_layer	0.94300259
58	MP0003638_abnormal_response/metabolism_	0.92579379
59	MP0003195_calcinosis	0.88014242
60	MP0010155_abnormal_intestine_physiology	0.87586287
61	MP0006036_abnormal_mitochondrial_physio	0.86724466
62	MP0000377_abnormal_hair_follicle	0.86484714
63	MP0003984_embryonic_growth_retardation	0.85447243
64	MP0010329_abnormal_lipoprotein_level	0.84983743
65	MP0003186_abnormal_redox_activity	0.83726861
66	MP0003959_abnormal_lean_body	0.83468227
67	MP0003315_abnormal_perineum_morphology	0.82550831
68	MP0002088_abnormal_embryonic_growth/wei	0.82527455
69	MP0005670_abnormal_white_adipose	0.82130565
70	MP0002136_abnormal_kidney_physiology	0.82105051
71	MP0005380_embryogenesis_phenotype	0.82012995
72	MP0001672_abnormal_embryogenesis/_devel	0.82012995
73	MP0003941_abnormal_skin_development	0.79754262
74	MP0003718_maternal_effect	0.77841820
75	MP0003111_abnormal_nucleus_morphology	0.77624285
76	MP0000762_abnormal_tongue_morphology	0.77284693
77	MP0002163_abnormal_gland_morphology	0.76970102
78	MP0001756_abnormal_urination	0.75422873
79	MP0002111_abnormal_tail_morphology	0.75109092
80	MP0005167_abnormal_blood-brain_barrier	0.74597146
81	MP0001849_ear_inflammation	0.74028238
82	MP0000538_abnormal_urinary_bladder	0.73910500
83	MP0000383_abnormal_hair_follicle	0.73824488
84	MP0000467_abnormal_esophagus_morphology	0.73723742
85	MP0003879_abnormal_hair_cell	0.73498306
86	MP0000427_abnormal_hair_cycle	0.73453433
87	MP0004381_abnormal_hair_follicle	0.73253327
88	MP0000609_abnormal_liver_physiology	0.72239644
89	MP0003183_abnormal_peptide_metabolism	0.72142743
90	MP0005058_abnormal_lysosome_morphology	0.70757259
91	MP0000647_abnormal_sebaceous_gland	0.68098705
92	MP0005319_abnormal_enzyme/_coenzyme	0.68042789
93	MP0002102_abnormal_ear_morphology	0.67868890
94	MP0006035_abnormal_mitochondrial_morpho	0.67718415
95	MP0002118_abnormal_lipid_homeostasis	0.67411743
96	MP0000627_abnormal_mammary_gland	0.66996120
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.66754126
98	MP0001697_abnormal_embryo_size	0.66611470
99	MP0010771_integument_phenotype	0.65809879
100	MP0001881_abnormal_mammary_gland	0.64762450

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.90660886
2	Abnormality of alanine metabolism (HP:0010916)	4.13176030
3	Hyperalaninemia (HP:0003348)	4.13176030
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.13176030
5	Abnormality of proline metabolism (HP:0010907)	4.06229565
6	Hydroxyprolinuria (HP:0003080)	4.06229565
7	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.69386223
8	Proximal tubulopathy (HP:0000114)	3.33762391
9	Alkalosis (HP:0001948)	3.29491984
10	Hyperactive renin-angiotensin system (HP:0000841)	3.23582733
11	Right ventricular cardiomyopathy (HP:0011663)	3.23287720
12	Hyperammonemia (HP:0001987)	3.12909180
13	Amelogenesis imperfecta (HP:0000705)	3.10823932
14	Delayed CNS myelination (HP:0002188)	3.07696776
15	Abnormality of glycine metabolism (HP:0010895)	3.01790445
16	Abnormality of serine family amino acid metabolism (HP:0010894)	3.01790445
17	Flat acetabular roof (HP:0003180)	2.98943438
18	Abnormality of serum amino acid levels (HP:0003112)	2.94366019
19	Generalized aminoaciduria (HP:0002909)	2.87053010
20	Hyperglycinuria (HP:0003108)	2.86023172
21	Abnormality of renin-angiotensin system (HP:0000847)	2.85524151
22	Rough bone trabeculation (HP:0100670)	2.82753525
23	Confusion (HP:0001289)	2.80728178
24	Hyperglycinemia (HP:0002154)	2.69797364
25	Abnormal trabecular bone morphology (HP:0100671)	2.69736973
26	Malnutrition (HP:0004395)	2.68901801
27	Microretrognathia (HP:0000308)	2.68542720
28	Decreased circulating renin level (HP:0003351)	2.67051245
29	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.61647136
30	Abnormality of pyrimidine metabolism (HP:0004353)	2.61142451
31	Abnormality of urine glucose concentration (HP:0011016)	2.58285205
32	Glycosuria (HP:0003076)	2.58285205
33	Ileus (HP:0002595)	2.57425812
34	Intrahepatic cholestasis (HP:0001406)	2.57343388
35	Vacuolated lymphocytes (HP:0001922)	2.54824623
36	Late onset (HP:0003584)	2.54580915
37	Hypoglycemic coma (HP:0001325)	2.51728844
38	Abdominal distention (HP:0003270)	2.50192660
39	Fat malabsorption (HP:0002630)	2.49493841
40	Cone-rod dystrophy (HP:0000548)	2.48474189
41	Metabolic alkalosis (HP:0200114)	2.47952857
42	Abnormal tarsal ossification (HP:0008369)	2.42548297
43	Abnormality of vitamin B metabolism (HP:0004340)	2.41496503
44	Steatorrhea (HP:0002570)	2.36533648
45	Micronodular cirrhosis (HP:0001413)	2.30095366
46	Renal tubular acidosis (HP:0001947)	2.28790648
47	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.25922996
48	Lethargy (HP:0001254)	2.23796491
49	Ureteral duplication (HP:0000073)	2.22450454
50	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.19674566
51	Cerebellar dysplasia (HP:0007033)	2.18653089
52	Abnormality of vitamin metabolism (HP:0100508)	2.17066118
53	Pili torti (HP:0003777)	2.15969625
54	Rectal prolapse (HP:0002035)	2.13243302
55	Hepatic necrosis (HP:0002605)	2.12629777
56	Nausea (HP:0002018)	2.12158182
57	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.10778240
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.09154997
59	Dicarboxylic aciduria (HP:0003215)	2.09154997
60	Cervical subluxation (HP:0003308)	2.05958610
61	Metabolic acidosis (HP:0001942)	2.04515301
62	Oral leukoplakia (HP:0002745)	2.03938407
63	Abnormality of magnesium homeostasis (HP:0004921)	2.01656184
64	Increased serum lactate (HP:0002151)	1.97210544
65	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.97146524
66	Renal tubular dysfunction (HP:0000124)	1.93879153
67	Abnormality of dental color (HP:0011073)	1.92263048
68	Birth length less than 3rd percentile (HP:0003561)	1.91471167
69	Hypobetalipoproteinemia (HP:0003563)	1.91260023
70	Cerebral palsy (HP:0100021)	1.89213255
71	Type II lissencephaly (HP:0007260)	1.87626093
72	Lipid accumulation in hepatocytes (HP:0006561)	1.87062478
73	Abnormality of the umbilical cord (HP:0010881)	1.85588930
74	Abnormality of fatty-acid metabolism (HP:0004359)	1.82904840
75	Abnormal hair laboratory examination (HP:0003328)	1.80923617
76	Reduced subcutaneous adipose tissue (HP:0003758)	1.79235121
77	Widely patent fontanelles and sutures (HP:0004492)	1.78467192
78	Biliary tract neoplasm (HP:0100574)	1.77339334
79	Abnormal umbilical cord blood vessels (HP:0011403)	1.75904518
80	Single umbilical artery (HP:0001195)	1.75904518
81	Abnormality of the fetal cardiovascular system (HP:0010948)	1.75904518
82	Abnormal biliary tract morphology (HP:0012440)	1.75507865
83	Hyperphosphaturia (HP:0003109)	1.75066889
84	Increased serum pyruvate (HP:0003542)	1.72795731
85	Multiple enchondromatosis (HP:0005701)	1.71939649
86	Abnormality of nucleobase metabolism (HP:0010932)	1.71733187
87	Abnormality of carpal bone ossification (HP:0006257)	1.69966376
88	Death in infancy (HP:0001522)	1.69509307
89	Microvesicular hepatic steatosis (HP:0001414)	1.69472126
90	Unilateral renal agenesis (HP:0000122)	1.69310243
91	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.68971486
92	Lactic acidosis (HP:0003128)	1.68636897
93	Double outlet right ventricle (HP:0001719)	1.67226103
94	Congenital malformation of the right heart (HP:0011723)	1.67226103
95	Dehydration (HP:0001944)	1.67198223
96	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.66861296
97	Megaloblastic anemia (HP:0001889)	1.66108469
98	Abnormality of glycolysis (HP:0004366)	1.65118029
99	Brushfield spots (HP:0001088)	1.63963408
100	Hepatocellular necrosis (HP:0001404)	1.63904803

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.99097790
2	MST1R	4.80860059
3	MST4	3.31575216
4	VRK2	2.92524101
5	WNK4	2.57106436
6	TLK1	2.51448622
7	MET	2.45214979
8	STK39	2.40825560
9	ACVR1B	2.27798508
10	MAP3K12	2.26366090
11	PBK	2.25754105
12	NME2	2.22575719
13	EIF2AK1	1.87591271
14	PAK4	1.84665110
15	NEK1	1.81480059
16	TRIB3	1.78087103
17	RPS6KB2	1.72601473
18	PDK2	1.71761008
19	LMTK2	1.68986622
20	INSRR	1.67503193
21	PIK3CA	1.64970206
22	OXSR1	1.59990709
23	TESK1	1.52978604
24	PTK6	1.49589471
25	LIMK1	1.34962057
26	NME1	1.31254779
27	SRPK1	1.21851416
28	ABL2	1.21440330
29	SMG1	1.20744695
30	PRKCI	1.20273687
31	STK16	1.19403478
32	EIF2AK3	1.14581086
33	AURKB	1.07998751
34	ILK	1.07535105
35	ADRBK2	1.06186340
36	PRKG2	1.05591955
37	DAPK1	1.02157401
38	CDK19	0.99646550
39	GRK1	0.98989996
40	MAP3K8	0.98442747
41	SCYL2	0.98067304
42	IRAK3	0.96527600
43	CDK9	0.96479962
44	FER	0.95321420
45	ZAK	0.94058764
46	TRIM28	0.93630640
47	EPHB2	0.91876090
48	CAMK2D	0.90663522
49	MAPKAPK3	0.89607371
50	MAP2K2	0.86728497
51	BUB1	0.85869488
52	TSSK6	0.84392341
53	BCKDK	0.81748249
54	VRK1	0.78734728
55	CAMK2G	0.78403692
56	ERBB4	0.78126533
57	NUAK1	0.73569348
58	PTK2	0.71168889
59	NEK2	0.69155095
60	LATS1	0.68112545
61	DAPK3	0.67422712
62	MAP3K9	0.66279861
63	MYLK	0.65659961
64	ERN1	0.62982758
65	AKT2	0.61210975
66	CAMK2B	0.58852321
67	TIE1	0.57210041
68	MAP2K7	0.56650277
69	CDK7	0.56276214
70	RIPK1	0.55860462
71	TTK	0.55859445
72	PLK1	0.52394802
73	STK24	0.52229258
74	RPS6KA5	0.51469960
75	PLK4	0.51040179
76	CHUK	0.49890046
77	MAP2K1	0.49289333
78	CDK12	0.48958896
79	SIK1	0.48663793
80	TAF1	0.48641639
81	CDK8	0.47935967
82	TESK2	0.47788100
83	PKN2	0.42124062
84	PASK	0.40354118
85	ARAF	0.38522418
86	MAP3K13	0.36768980
87	BRSK1	0.35840086
88	RPS6KA4	0.35382886
89	MELK	0.35315531
90	MAP2K6	0.34175772
91	PIM2	0.33158734
92	MAP3K11	0.32903493
93	MATK	0.32683127
94	CSNK1G3	0.32327511
95	BRSK2	0.32100040
96	AURKA	0.31999673
97	PDPK1	0.30579600
98	CSNK2A1	0.29117108
99	STK3	0.29078418
100	LRRK2	0.28765266

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	3.81907100
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.10513296
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.75140225
4	Sulfur relay system_Homo sapiens_hsa04122	2.67652721
5	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.48198547
6	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.21465235
7	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.21086600
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.20131491
9	Fat digestion and absorption_Homo sapiens_hsa04975	2.10208267
10	Galactose metabolism_Homo sapiens_hsa00052	1.93705300
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.87893366
12	Arginine and proline metabolism_Homo sapiens_hsa00330	1.86393987
13	Proteasome_Homo sapiens_hsa03050	1.79873687
14	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.78563309
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.76250570
16	Glutathione metabolism_Homo sapiens_hsa00480	1.75308630
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.70865433
18	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.69941665
19	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.69351631
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.59231619
21	Retinol metabolism_Homo sapiens_hsa00830	1.58556380
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57046351
23	Chemical carcinogenesis_Homo sapiens_hsa05204	1.56475719
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.55293189
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.52821384
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52028064
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.49625937
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.47452956
29	Fatty acid elongation_Homo sapiens_hsa00062	1.46491283
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46465651
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.39133584
32	DNA replication_Homo sapiens_hsa03030	1.36884886
33	Ribosome_Homo sapiens_hsa03010	1.36294103
34	Bile secretion_Homo sapiens_hsa04976	1.35514898
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34543125
36	Histidine metabolism_Homo sapiens_hsa00340	1.34393756
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.33392094
38	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.33064247
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33015782
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.31735306
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.29684581
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.29410745
43	Mineral absorption_Homo sapiens_hsa04978	1.28098709
44	Carbon metabolism_Homo sapiens_hsa01200	1.27975123
45	Peroxisome_Homo sapiens_hsa04146	1.23573784
46	Renin-angiotensin system_Homo sapiens_hsa04614	1.21899575
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.19270551
48	Protein digestion and absorption_Homo sapiens_hsa04974	1.18088276
49	Fatty acid degradation_Homo sapiens_hsa00071	1.15881313
50	Tryptophan metabolism_Homo sapiens_hsa00380	1.09290597
51	Butanoate metabolism_Homo sapiens_hsa00650	1.07467447
52	Folate biosynthesis_Homo sapiens_hsa00790	1.06439420
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00018778
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98855353
55	Mismatch repair_Homo sapiens_hsa03430	0.96172731
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95858387
57	Phenylalanine metabolism_Homo sapiens_hsa00360	0.95678281
58	Caffeine metabolism_Homo sapiens_hsa00232	0.93386807
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91976947
60	Oxidative phosphorylation_Homo sapiens_hsa00190	0.89024321
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88133622
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.87366558
63	RNA polymerase_Homo sapiens_hsa03020	0.85780212
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85758314
65	Pancreatic secretion_Homo sapiens_hsa04972	0.82874011
66	Vibrio cholerae infection_Homo sapiens_hsa05110	0.80825684
67	One carbon pool by folate_Homo sapiens_hsa00670	0.79932877
68	Propanoate metabolism_Homo sapiens_hsa00640	0.78530639
69	Metabolic pathways_Homo sapiens_hsa01100	0.78183366
70	Other glycan degradation_Homo sapiens_hsa00511	0.77492862
71	Base excision repair_Homo sapiens_hsa03410	0.75600508
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75040184
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73759063
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71947613
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69325296
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69178051
77	Basal transcription factors_Homo sapiens_hsa03022	0.68369177
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68111172
79	Tight junction_Homo sapiens_hsa04530	0.67771140
80	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.65100293
81	Pentose phosphate pathway_Homo sapiens_hsa00030	0.63355876
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.62696531
83	Purine metabolism_Homo sapiens_hsa00230	0.62584780
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.60662029
85	Homologous recombination_Homo sapiens_hsa03440	0.60452092
86	Spliceosome_Homo sapiens_hsa03040	0.55243983
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.55029904
88	Parkinsons disease_Homo sapiens_hsa05012	0.51998652
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.51389728
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.50772343
91	RNA transport_Homo sapiens_hsa03013	0.50459667
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.47595146
93	Huntingtons disease_Homo sapiens_hsa05016	0.47374774
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46966957
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.40831908
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37856793
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36654043
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36633333
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34375196
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32040176

KRT8P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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