KRT8P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)4.62958159
2glucuronate metabolic process (GO:0019585)4.48798255
3uronic acid metabolic process (GO:0006063)4.48798255
4cellular glucuronidation (GO:0052695)4.47948822
5response to food (GO:0032094)4.28102994
6desmosome organization (GO:0002934)4.21187424
7bundle of His cell to Purkinje myocyte communication (GO:0086069)4.00238970
8intestinal absorption (GO:0050892)3.88977943
9daunorubicin metabolic process (GO:0044597)3.81783614
10polyketide metabolic process (GO:0030638)3.81783614
11doxorubicin metabolic process (GO:0044598)3.81783614
12flavonoid metabolic process (GO:0009812)3.74031897
13GDP-mannose metabolic process (GO:0019673)3.67914225
14nucleotide-sugar biosynthetic process (GO:0009226)3.60752987
15calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.57710945
16sulfur amino acid catabolic process (GO:0000098)3.53384229
17NADH metabolic process (GO:0006734)3.50968669
18phenylpropanoid metabolic process (GO:0009698)3.47924009
19cysteine metabolic process (GO:0006534)3.47234366
20vitamin transmembrane transport (GO:0035461)3.36876845
21regulation of guanylate cyclase activity (GO:0031282)3.36373823
22aminoglycoside antibiotic metabolic process (GO:0030647)3.34339033
23growth hormone secretion (GO:0030252)3.31352412
24quinone biosynthetic process (GO:1901663)3.30263721
25antibacterial humoral response (GO:0019731)3.24337339
26epoxygenase P450 pathway (GO:0019373)3.22742456
27bile acid and bile salt transport (GO:0015721)3.15107940
28homocysteine metabolic process (GO:0050667)3.14834032
29positive regulation of Cdc42 GTPase activity (GO:0043089)3.14756242
30notochord development (GO:0030903)3.14477468
31cobalamin metabolic process (GO:0009235)3.12656064
32positive regulation of glycoprotein metabolic process (GO:1903020)3.11221881
33regulation of viral release from host cell (GO:1902186)3.09021787
34primary alcohol catabolic process (GO:0034310)3.07195594
35galactose catabolic process (GO:0019388)3.00398938
36respiratory tube development (GO:0030323)2.98907098
37ribosome assembly (GO:0042255)2.98866488
38formation of translation preinitiation complex (GO:0001731)2.98001023
39protein autoprocessing (GO:0016540)2.97100280
40antimicrobial humoral response (GO:0019730)2.96739994
41lung epithelium development (GO:0060428)2.96511312
42proline biosynthetic process (GO:0006561)2.95640284
43proline metabolic process (GO:0006560)2.95300162
44intestinal epithelial cell development (GO:0060576)2.94381902
45positive regulation of glycoprotein biosynthetic process (GO:0010560)2.94360833
46glucose 6-phosphate metabolic process (GO:0051156)2.94149373
47renal system process involved in regulation of blood volume (GO:0001977)2.93450550
48urate metabolic process (GO:0046415)2.92520559
49quinone metabolic process (GO:1901661)2.91108578
50cyclooxygenase pathway (GO:0019371)2.90593046
51L-serine metabolic process (GO:0006563)2.86311880
52L-phenylalanine metabolic process (GO:0006558)2.85907165
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85907165
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84439039
55regulation of cellular respiration (GO:0043457)2.79609318
56positive regulation of pseudopodium assembly (GO:0031274)2.78782040
57digestion (GO:0007586)2.77636071
58serine family amino acid biosynthetic process (GO:0009070)2.77320787
59drug transmembrane transport (GO:0006855)2.76842772
60proteasome assembly (GO:0043248)2.75483076
61regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.74837940
62endocrine process (GO:0050886)2.74837940
63regulation of systemic arterial blood pressure by hormone (GO:0001990)2.74837940
64regulation of cardioblast differentiation (GO:0051890)2.73659405
65COPI coating of Golgi vesicle (GO:0048205)2.73340817
66Golgi transport vesicle coating (GO:0048200)2.73340817
67purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.72688972
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.72688972
69lung-associated mesenchyme development (GO:0060484)2.71763617
70ubiquinone biosynthetic process (GO:0006744)2.69643079
71tight junction assembly (GO:0070830)2.68751361
72nuclear envelope reassembly (GO:0031468)2.67543650
73mitotic nuclear envelope reassembly (GO:0007084)2.67543650
74serine family amino acid metabolic process (GO:0009069)2.66122607
75urea cycle (GO:0000050)2.65916334
76sperm capacitation (GO:0048240)2.65801301
77prostaglandin metabolic process (GO:0006693)2.65417767
78prostanoid metabolic process (GO:0006692)2.65417767
79glycoside metabolic process (GO:0016137)2.62433174
80UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62338818
81water-soluble vitamin biosynthetic process (GO:0042364)2.60856616
82regulation of systemic arterial blood pressure (GO:0003073)2.58153385
83prostaglandin biosynthetic process (GO:0001516)2.56639082
84prostanoid biosynthetic process (GO:0046457)2.56639082
85sulfate transport (GO:0008272)2.55960429
86sulfur compound transport (GO:0072348)2.54691065
87urea metabolic process (GO:0019627)2.53032627
88arginine metabolic process (GO:0006525)2.51250983
89tricarboxylic acid cycle (GO:0006099)2.51193052
90ribosomal large subunit biogenesis (GO:0042273)2.47814022
91cellular response to pH (GO:0071467)2.47598626
92tRNA methylation (GO:0030488)2.45893843
93vitamin biosynthetic process (GO:0009110)2.45527653
94glutathione biosynthetic process (GO:0006750)2.45261728
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.43485319
96hepatocyte apoptotic process (GO:0097284)2.42887730
97sulfate transmembrane transport (GO:1902358)2.42421832
98nonribosomal peptide biosynthetic process (GO:0019184)2.42142556
99regulation of viral entry into host cell (GO:0046596)2.42084862
100phosphate ion transmembrane transport (GO:0035435)2.41889142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88906943
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66083234
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.57517800
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.55729195
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52781643
6ZNF263_19887448_ChIP-Seq_K562_Human2.51752545
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.34196879
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32403746
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.29766347
10GATA6_25053715_ChIP-Seq_YYC3_Human2.28408517
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24662902
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21917660
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21742079
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16965049
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15149634
16GATA4_25053715_ChIP-Seq_YYC3_Human2.10960145
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09286356
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.07901316
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.05308687
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99183373
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98108216
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.91507122
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85984411
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83454228
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78275148
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76161012
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.74133570
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.71998499
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71542436
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70260515
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67529333
32DCP1A_22483619_ChIP-Seq_HELA_Human1.66564621
33AR_21909140_ChIP-Seq_LNCAP_Human1.65887274
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65806264
35XRN2_22483619_ChIP-Seq_HELA_Human1.65115921
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64269047
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.62308028
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62167610
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61544168
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61468386
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59895522
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59107685
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58152609
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57330464
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.55958779
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52896844
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.51857868
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51734011
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50434034
50GABP_19822575_ChIP-Seq_HepG2_Human1.48658942
51SOX2_20726797_ChIP-Seq_SW620_Human1.47235207
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42280916
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42025959
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.40602582
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.40554198
56ATF3_27146783_Chip-Seq_COLON_Human1.40176606
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.38795072
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34845022
59TTF2_22483619_ChIP-Seq_HELA_Human1.33895885
60KDM5A_27292631_Chip-Seq_BREAST_Human1.33019707
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32929684
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30720335
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28429202
64P68_20966046_ChIP-Seq_HELA_Human1.26967157
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26337315
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24382211
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23517333
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23267763
69ELF5_23300383_ChIP-Seq_T47D_Human1.22985813
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22695436
71RACK7_27058665_Chip-Seq_MCF-7_Human1.21463717
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19590625
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18112343
74E2F1_20622854_ChIP-Seq_HELA_Human1.17790456
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17781077
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.17318168
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16591284
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16220130
79PHF8_20622854_ChIP-Seq_HELA_Human1.15015503
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14554861
81RARA_24833708_ChIP-Seq_LIVER_Mouse1.12914250
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11567456
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.11251773
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.10917428
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09422659
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08463688
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06982948
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05893417
89BCOR_27268052_Chip-Seq_Bcells_Human1.04692971
90TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.03986094
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02744042
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00578550
93RUNX1_27514584_Chip-Seq_MCF-7_Human0.98364229
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94666247
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92875629
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92475259
97FOXP3_21729870_ChIP-Seq_TREG_Human0.91819193
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91612337
99LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91612163
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.91483893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.84973183
2MP0005360_urolithiasis4.48863696
3MP0002139_abnormal_hepatobiliary_system4.35330376
4MP0002138_abnormal_hepatobiliary_system4.18651943
5MP0003693_abnormal_embryo_hatching3.66919423
6MP0004264_abnormal_extraembryonic_tissu3.39575567
7MP0001666_abnormal_nutrient_absorption3.08226581
8MP0002796_impaired_skin_barrier2.91876895
9MP0004147_increased_porphyrin_level2.77798590
10MP0008875_abnormal_xenobiotic_pharmacok2.74788579
11MP0010030_abnormal_orbit_morphology2.72972347
12MP0005085_abnormal_gallbladder_physiolo2.52214624
13MP0003806_abnormal_nucleotide_metabolis2.50464889
14MP0005365_abnormal_bile_salt2.38145985
15MP0004957_abnormal_blastocyst_morpholog2.16022653
16MP0004019_abnormal_vitamin_homeostasis2.13389917
17MP0008872_abnormal_physiological_respon2.10346575
18MP0003868_abnormal_feces_composition2.07010066
19MP0000537_abnormal_urethra_morphology2.02517611
20MP0005451_abnormal_body_composition2.02252752
21MP0010352_gastrointestinal_tract_polyps1.96334972
22MP0009379_abnormal_foot_pigmentation1.95248165
23MP0005501_abnormal_skin_physiology1.76873385
24MP0009840_abnormal_foam_cell1.63933869
25MP0000490_abnormal_crypts_of1.63723762
26MP0009643_abnormal_urine_homeostasis1.58259224
27MP0002098_abnormal_vibrissa_morphology1.54964426
28MP0004782_abnormal_surfactant_physiolog1.54652823
29MP0003866_abnormal_defecation1.53625589
30MP0002876_abnormal_thyroid_physiology1.50303076
31MP0005332_abnormal_amino_acid1.50183421
32MP0004858_abnormal_nervous_system1.48325881
33MP0001664_abnormal_digestion1.41536455
34MP0000566_synostosis1.32139277
35MP0000477_abnormal_intestine_morphology1.30955281
36MP0010678_abnormal_skin_adnexa1.29561571
37MP0000462_abnormal_digestive_system1.27707214
38MP0005636_abnormal_mineral_homeostasis1.27676919
39MP0001346_abnormal_lacrimal_gland1.27494760
40MP0008932_abnormal_embryonic_tissue1.22611056
41MP0001765_abnormal_ion_homeostasis1.20042985
42MP0004043_abnormal_pH_regulation1.14766407
43MP0001663_abnormal_digestive_system1.13912506
44MP0001873_stomach_inflammation1.13849946
45MP0005220_abnormal_exocrine_pancreas1.12768212
46MP0003119_abnormal_digestive_system1.11152948
47MP0000678_abnormal_parathyroid_gland1.11093838
48MP0005083_abnormal_biliary_tract1.11038025
49MP0001764_abnormal_homeostasis1.10400035
50MP0005248_abnormal_Harderian_gland1.09939818
51MP0005381_digestive/alimentary_phenotyp1.06429872
52MP0001727_abnormal_embryo_implantation1.00545538
53MP0003566_abnormal_cell_adhesion0.99732446
54MP0010094_abnormal_chromosome_stability0.98155129
55MP0005075_abnormal_melanosome_morpholog0.98067149
56MP0001730_embryonic_growth_arrest0.96924153
57MP0001216_abnormal_epidermal_layer0.94300259
58MP0003638_abnormal_response/metabolism_0.92579379
59MP0003195_calcinosis0.88014242
60MP0010155_abnormal_intestine_physiology0.87586287
61MP0006036_abnormal_mitochondrial_physio0.86724466
62MP0000377_abnormal_hair_follicle0.86484714
63MP0003984_embryonic_growth_retardation0.85447243
64MP0010329_abnormal_lipoprotein_level0.84983743
65MP0003186_abnormal_redox_activity0.83726861
66MP0003959_abnormal_lean_body0.83468227
67MP0003315_abnormal_perineum_morphology0.82550831
68MP0002088_abnormal_embryonic_growth/wei0.82527455
69MP0005670_abnormal_white_adipose0.82130565
70MP0002136_abnormal_kidney_physiology0.82105051
71MP0005380_embryogenesis_phenotype0.82012995
72MP0001672_abnormal_embryogenesis/_devel0.82012995
73MP0003941_abnormal_skin_development0.79754262
74MP0003718_maternal_effect0.77841820
75MP0003111_abnormal_nucleus_morphology0.77624285
76MP0000762_abnormal_tongue_morphology0.77284693
77MP0002163_abnormal_gland_morphology0.76970102
78MP0001756_abnormal_urination0.75422873
79MP0002111_abnormal_tail_morphology0.75109092
80MP0005167_abnormal_blood-brain_barrier0.74597146
81MP0001849_ear_inflammation0.74028238
82MP0000538_abnormal_urinary_bladder0.73910500
83MP0000383_abnormal_hair_follicle0.73824488
84MP0000467_abnormal_esophagus_morphology0.73723742
85MP0003879_abnormal_hair_cell0.73498306
86MP0000427_abnormal_hair_cycle0.73453433
87MP0004381_abnormal_hair_follicle0.73253327
88MP0000609_abnormal_liver_physiology0.72239644
89MP0003183_abnormal_peptide_metabolism0.72142743
90MP0005058_abnormal_lysosome_morphology0.70757259
91MP0000647_abnormal_sebaceous_gland0.68098705
92MP0005319_abnormal_enzyme/_coenzyme0.68042789
93MP0002102_abnormal_ear_morphology0.67868890
94MP0006035_abnormal_mitochondrial_morpho0.67718415
95MP0002118_abnormal_lipid_homeostasis0.67411743
96MP0000627_abnormal_mammary_gland0.66996120
97MP0005584_abnormal_enzyme/coenzyme_acti0.66754126
98MP0001697_abnormal_embryo_size0.66611470
99MP0010771_integument_phenotype0.65809879
100MP0001881_abnormal_mammary_gland0.64762450

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.90660886
2Abnormality of alanine metabolism (HP:0010916)4.13176030
3Hyperalaninemia (HP:0003348)4.13176030
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.13176030
5Abnormality of proline metabolism (HP:0010907)4.06229565
6Hydroxyprolinuria (HP:0003080)4.06229565
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.69386223
8Proximal tubulopathy (HP:0000114)3.33762391
9Alkalosis (HP:0001948)3.29491984
10Hyperactive renin-angiotensin system (HP:0000841)3.23582733
11Right ventricular cardiomyopathy (HP:0011663)3.23287720
12Hyperammonemia (HP:0001987)3.12909180
13Amelogenesis imperfecta (HP:0000705)3.10823932
14Delayed CNS myelination (HP:0002188)3.07696776
15Abnormality of serine family amino acid metabolism (HP:0010894)3.01790445
16Abnormality of glycine metabolism (HP:0010895)3.01790445
17Flat acetabular roof (HP:0003180)2.98943438
18Abnormality of serum amino acid levels (HP:0003112)2.94366019
19Generalized aminoaciduria (HP:0002909)2.87053010
20Hyperglycinuria (HP:0003108)2.86023172
21Abnormality of renin-angiotensin system (HP:0000847)2.85524151
22Rough bone trabeculation (HP:0100670)2.82753525
23Confusion (HP:0001289)2.80728178
24Hyperglycinemia (HP:0002154)2.69797364
25Abnormal trabecular bone morphology (HP:0100671)2.69736973
26Malnutrition (HP:0004395)2.68901801
27Microretrognathia (HP:0000308)2.68542720
28Decreased circulating renin level (HP:0003351)2.67051245
29Abnormality of the vitamin B12 metabolism (HP:0004341)2.61647136
30Abnormality of pyrimidine metabolism (HP:0004353)2.61142451
31Glycosuria (HP:0003076)2.58285205
32Abnormality of urine glucose concentration (HP:0011016)2.58285205
33Ileus (HP:0002595)2.57425812
34Intrahepatic cholestasis (HP:0001406)2.57343388
35Vacuolated lymphocytes (HP:0001922)2.54824623
36Late onset (HP:0003584)2.54580915
37Hypoglycemic coma (HP:0001325)2.51728844
38Abdominal distention (HP:0003270)2.50192660
39Fat malabsorption (HP:0002630)2.49493841
40Cone-rod dystrophy (HP:0000548)2.48474189
41Metabolic alkalosis (HP:0200114)2.47952857
42Abnormal tarsal ossification (HP:0008369)2.42548297
43Abnormality of vitamin B metabolism (HP:0004340)2.41496503
44Steatorrhea (HP:0002570)2.36533648
45Micronodular cirrhosis (HP:0001413)2.30095366
46Renal tubular acidosis (HP:0001947)2.28790648
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.25922996
48Lethargy (HP:0001254)2.23796491
49Ureteral duplication (HP:0000073)2.22450454
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19674566
51Cerebellar dysplasia (HP:0007033)2.18653089
52Abnormality of vitamin metabolism (HP:0100508)2.17066118
53Pili torti (HP:0003777)2.15969625
54Rectal prolapse (HP:0002035)2.13243302
55Hepatic necrosis (HP:0002605)2.12629777
56Nausea (HP:0002018)2.12158182
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10778240
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09154997
59Dicarboxylic aciduria (HP:0003215)2.09154997
60Cervical subluxation (HP:0003308)2.05958610
61Metabolic acidosis (HP:0001942)2.04515301
62Oral leukoplakia (HP:0002745)2.03938407
63Abnormality of magnesium homeostasis (HP:0004921)2.01656184
64Increased serum lactate (HP:0002151)1.97210544
65Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97146524
66Renal tubular dysfunction (HP:0000124)1.93879153
67Abnormality of dental color (HP:0011073)1.92263048
68Birth length less than 3rd percentile (HP:0003561)1.91471167
69Hypobetalipoproteinemia (HP:0003563)1.91260023
70Cerebral palsy (HP:0100021)1.89213255
71Type II lissencephaly (HP:0007260)1.87626093
72Lipid accumulation in hepatocytes (HP:0006561)1.87062478
73Abnormality of the umbilical cord (HP:0010881)1.85588930
74Abnormality of fatty-acid metabolism (HP:0004359)1.82904840
75Abnormal hair laboratory examination (HP:0003328)1.80923617
76Reduced subcutaneous adipose tissue (HP:0003758)1.79235121
77Widely patent fontanelles and sutures (HP:0004492)1.78467192
78Biliary tract neoplasm (HP:0100574)1.77339334
79Abnormality of the fetal cardiovascular system (HP:0010948)1.75904518
80Abnormal umbilical cord blood vessels (HP:0011403)1.75904518
81Single umbilical artery (HP:0001195)1.75904518
82Abnormal biliary tract morphology (HP:0012440)1.75507865
83Hyperphosphaturia (HP:0003109)1.75066889
84Increased serum pyruvate (HP:0003542)1.72795731
85Multiple enchondromatosis (HP:0005701)1.71939649
86Abnormality of nucleobase metabolism (HP:0010932)1.71733187
87Abnormality of carpal bone ossification (HP:0006257)1.69966376
88Death in infancy (HP:0001522)1.69509307
89Microvesicular hepatic steatosis (HP:0001414)1.69472126
90Unilateral renal agenesis (HP:0000122)1.69310243
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.68971486
92Lactic acidosis (HP:0003128)1.68636897
93Congenital malformation of the right heart (HP:0011723)1.67226103
94Double outlet right ventricle (HP:0001719)1.67226103
95Dehydration (HP:0001944)1.67198223
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66861296
97Megaloblastic anemia (HP:0001889)1.66108469
98Abnormality of glycolysis (HP:0004366)1.65118029
99Brushfield spots (HP:0001088)1.63963408
100Hepatocellular necrosis (HP:0001404)1.63904803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.99097790
2MST1R4.80860059
3MST43.31575216
4VRK22.92524101
5WNK42.57106436
6TLK12.51448622
7MET2.45214979
8STK392.40825560
9ACVR1B2.27798508
10MAP3K122.26366090
11PBK2.25754105
12NME22.22575719
13EIF2AK11.87591271
14PAK41.84665110
15NEK11.81480059
16TRIB31.78087103
17RPS6KB21.72601473
18PDK21.71761008
19LMTK21.68986622
20INSRR1.67503193
21PIK3CA1.64970206
22OXSR11.59990709
23TESK11.52978604
24PTK61.49589471
25LIMK11.34962057
26NME11.31254779
27SRPK11.21851416
28ABL21.21440330
29SMG11.20744695
30PRKCI1.20273687
31STK161.19403478
32EIF2AK31.14581086
33AURKB1.07998751
34ILK1.07535105
35ADRBK21.06186340
36PRKG21.05591955
37DAPK11.02157401
38CDK190.99646550
39GRK10.98989996
40MAP3K80.98442747
41SCYL20.98067304
42IRAK30.96527600
43CDK90.96479962
44FER0.95321420
45ZAK0.94058764
46TRIM280.93630640
47EPHB20.91876090
48CAMK2D0.90663522
49MAPKAPK30.89607371
50MAP2K20.86728497
51BUB10.85869488
52TSSK60.84392341
53BCKDK0.81748249
54VRK10.78734728
55CAMK2G0.78403692
56ERBB40.78126533
57NUAK10.73569348
58PTK20.71168889
59NEK20.69155095
60LATS10.68112545
61DAPK30.67422712
62MAP3K90.66279861
63MYLK0.65659961
64ERN10.62982758
65AKT20.61210975
66CAMK2B0.58852321
67TIE10.57210041
68MAP2K70.56650277
69CDK70.56276214
70RIPK10.55860462
71TTK0.55859445
72PLK10.52394802
73STK240.52229258
74RPS6KA50.51469960
75PLK40.51040179
76CHUK0.49890046
77MAP2K10.49289333
78CDK120.48958896
79SIK10.48663793
80TAF10.48641639
81CDK80.47935967
82TESK20.47788100
83PKN20.42124062
84PASK0.40354118
85ARAF0.38522418
86MAP3K130.36768980
87BRSK10.35840086
88RPS6KA40.35382886
89MELK0.35315531
90MAP2K60.34175772
91PIM20.33158734
92MAP3K110.32903493
93MATK0.32683127
94CSNK1G30.32327511
95BRSK20.32100040
96AURKA0.31999673
97PDPK10.30579600
98CSNK2A10.29117108
99STK30.29078418
100LRRK20.28765266

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.81907100
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.10513296
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75140225
4Sulfur relay system_Homo sapiens_hsa041222.67652721
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48198547
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21465235
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21086600
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20131491
9Fat digestion and absorption_Homo sapiens_hsa049752.10208267
10Galactose metabolism_Homo sapiens_hsa000521.93705300
11Nitrogen metabolism_Homo sapiens_hsa009101.87893366
12Arginine and proline metabolism_Homo sapiens_hsa003301.86393987
13Proteasome_Homo sapiens_hsa030501.79873687
14Fructose and mannose metabolism_Homo sapiens_hsa000511.78563309
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.76250570
16Glutathione metabolism_Homo sapiens_hsa004801.75308630
17Arginine biosynthesis_Homo sapiens_hsa002201.70865433
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.69941665
19Starch and sucrose metabolism_Homo sapiens_hsa005001.69351631
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59231619
21Retinol metabolism_Homo sapiens_hsa008301.58556380
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.57046351
23Chemical carcinogenesis_Homo sapiens_hsa052041.56475719
24Biosynthesis of amino acids_Homo sapiens_hsa012301.55293189
25Vitamin digestion and absorption_Homo sapiens_hsa049771.52821384
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.52028064
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49625937
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47452956
29Fatty acid elongation_Homo sapiens_hsa000621.46491283
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46465651
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39133584
32DNA replication_Homo sapiens_hsa030301.36884886
33Ribosome_Homo sapiens_hsa030101.36294103
34Bile secretion_Homo sapiens_hsa049761.35514898
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34543125
36Histidine metabolism_Homo sapiens_hsa003401.34393756
37Selenocompound metabolism_Homo sapiens_hsa004501.33392094
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33064247
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33015782
40Pyruvate metabolism_Homo sapiens_hsa006201.31735306
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29684581
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29410745
43Mineral absorption_Homo sapiens_hsa049781.28098709
44Carbon metabolism_Homo sapiens_hsa012001.27975123
45Peroxisome_Homo sapiens_hsa041461.23573784
46Renin-angiotensin system_Homo sapiens_hsa046141.21899575
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19270551
48Protein digestion and absorption_Homo sapiens_hsa049741.18088276
49Fatty acid degradation_Homo sapiens_hsa000711.15881313
50Tryptophan metabolism_Homo sapiens_hsa003801.09290597
51Butanoate metabolism_Homo sapiens_hsa006501.07467447
52Folate biosynthesis_Homo sapiens_hsa007901.06439420
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00018778
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98855353
55Mismatch repair_Homo sapiens_hsa034300.96172731
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95858387
57Phenylalanine metabolism_Homo sapiens_hsa003600.95678281
58Caffeine metabolism_Homo sapiens_hsa002320.93386807
59Pyrimidine metabolism_Homo sapiens_hsa002400.91976947
60Oxidative phosphorylation_Homo sapiens_hsa001900.89024321
61Collecting duct acid secretion_Homo sapiens_hsa049660.88133622
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87366558
63RNA polymerase_Homo sapiens_hsa030200.85780212
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.85758314
65Pancreatic secretion_Homo sapiens_hsa049720.82874011
66Vibrio cholerae infection_Homo sapiens_hsa051100.80825684
67One carbon pool by folate_Homo sapiens_hsa006700.79932877
68Propanoate metabolism_Homo sapiens_hsa006400.78530639
69Metabolic pathways_Homo sapiens_hsa011000.78183366
70Other glycan degradation_Homo sapiens_hsa005110.77492862
71Base excision repair_Homo sapiens_hsa034100.75600508
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75040184
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73759063
74Systemic lupus erythematosus_Homo sapiens_hsa053220.71947613
75beta-Alanine metabolism_Homo sapiens_hsa004100.69325296
76Linoleic acid metabolism_Homo sapiens_hsa005910.69178051
77Basal transcription factors_Homo sapiens_hsa030220.68369177
78Arachidonic acid metabolism_Homo sapiens_hsa005900.68111172
79Tight junction_Homo sapiens_hsa045300.67771140
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65100293
81Pentose phosphate pathway_Homo sapiens_hsa000300.63355876
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62696531
83Purine metabolism_Homo sapiens_hsa002300.62584780
84Nucleotide excision repair_Homo sapiens_hsa034200.60662029
85Homologous recombination_Homo sapiens_hsa034400.60452092
86Spliceosome_Homo sapiens_hsa030400.55243983
87Fatty acid metabolism_Homo sapiens_hsa012120.55029904
88Parkinsons disease_Homo sapiens_hsa050120.51998652
89Ether lipid metabolism_Homo sapiens_hsa005650.51389728
90PPAR signaling pathway_Homo sapiens_hsa033200.50772343
91RNA transport_Homo sapiens_hsa030130.50459667
92Tyrosine metabolism_Homo sapiens_hsa003500.47595146
93Huntingtons disease_Homo sapiens_hsa050160.47374774
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46966957
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40831908
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37856793
97N-Glycan biosynthesis_Homo sapiens_hsa005100.36654043
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36633333
99Sphingolipid metabolism_Homo sapiens_hsa006000.34375196
100Glycerolipid metabolism_Homo sapiens_hsa005610.32040176

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