KRT8P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-proline hydroxylation (GO:0019511)4.94836600
2neutrophil activation involved in immune response (GO:0002283)4.38302911
3protein hydroxylation (GO:0018126)4.30315841
4rRNA methylation (GO:0031167)4.09314201
5chromosome condensation (GO:0030261)4.04693701
6negative regulation of necroptotic process (GO:0060546)3.98543107
7fusion of sperm to egg plasma membrane (GO:0007342)3.98282231
8negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.98143168
9DNA packaging (GO:0006323)3.76504718
10rRNA modification (GO:0000154)3.69955723
11negative regulation of erythrocyte differentiation (GO:0045647)3.66034740
12regulation of T-helper 2 cell differentiation (GO:0045628)3.61914428
13response to peptidoglycan (GO:0032494)3.61605665
14positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.60382176
15regulation of mast cell degranulation (GO:0043304)3.43534695
16regulation of necroptotic process (GO:0060544)3.37287230
174-hydroxyproline metabolic process (GO:0019471)3.36584738
18regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.27373626
19carnitine transmembrane transport (GO:1902603)3.21342589
20pentose-phosphate shunt (GO:0006098)3.21201493
21skeletal muscle contraction (GO:0003009)3.20933786
22positive regulation of odontogenesis (GO:0042482)3.19389583
23response to muramyl dipeptide (GO:0032495)3.17931339
24positive regulation of myotube differentiation (GO:0010831)3.16023020
25acrosome reaction (GO:0007340)3.13963751
26sperm motility (GO:0030317)3.10239091
273-UTR-mediated mRNA stabilization (GO:0070935)3.06263541
28regulation of mast cell activation involved in immune response (GO:0033006)2.98336063
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93071406
30sperm capacitation (GO:0048240)2.88557551
31negative regulation of necrotic cell death (GO:0060547)2.88276651
32NIK/NF-kappaB signaling (GO:0038061)2.88061526
33cellular response to arsenic-containing substance (GO:0071243)2.84996703
34microtubule depolymerization (GO:0007019)2.82044272
35carnitine transport (GO:0015879)2.82018068
36amino-acid betaine transport (GO:0015838)2.82018068
37regulation of leukocyte degranulation (GO:0043300)2.82014978
38binding of sperm to zona pellucida (GO:0007339)2.81301529
39regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78711159
40positive regulation by symbiont of host defense response (GO:0052509)2.77642736
41modulation by symbiont of host defense response (GO:0052031)2.77642736
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77642736
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77642736
44positive regulation by organism of defense response of other organism involved in symbiotic interact2.77642736
45modulation by symbiont of host immune response (GO:0052553)2.77642736
46germinal center formation (GO:0002467)2.75558359
47membrane protein ectodomain proteolysis (GO:0006509)2.74302768
48purine nucleotide salvage (GO:0032261)2.72566237
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.71818199
50regulation of necrotic cell death (GO:0010939)2.70656637
51NADPH regeneration (GO:0006740)2.70222303
52cellular hyperosmotic response (GO:0071474)2.70006213
53autophagic vacuole fusion (GO:0000046)2.69393291
54cell wall macromolecule catabolic process (GO:0016998)2.67273429
55spermatid nucleus differentiation (GO:0007289)2.67217793
56plasma membrane fusion (GO:0045026)2.66688043
57pinocytosis (GO:0006907)2.64295773
58pentose metabolic process (GO:0019321)2.61047989
59lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60416086
60ether metabolic process (GO:0018904)2.58318675
61positive regulation of type 2 immune response (GO:0002830)2.56154147
62sexual reproduction (GO:0019953)2.56048448
63sperm-egg recognition (GO:0035036)2.55802215
64glucose catabolic process (GO:0006007)2.54823693
65negative regulation of granulocyte differentiation (GO:0030853)2.52760246
66spermatid development (GO:0007286)2.50863758
67glycerol ether metabolic process (GO:0006662)2.49340651
68motile cilium assembly (GO:0044458)2.47454596
69membrane protein intracellular domain proteolysis (GO:0031293)2.46444257
70centriole assembly (GO:0098534)2.45635335
71ribosome assembly (GO:0042255)2.45283470
72RNA methylation (GO:0001510)2.45265602
73spliceosomal tri-snRNP complex assembly (GO:0000244)2.45084106
74mitochondrial fusion (GO:0008053)2.42086730
75actin-myosin filament sliding (GO:0033275)2.41178009
76muscle filament sliding (GO:0030049)2.41178009
77positive regulation of mast cell activation involved in immune response (GO:0033008)2.41163049
78positive regulation of mast cell degranulation (GO:0043306)2.41163049
79response to thyroid hormone (GO:0097066)2.41147036
80positive regulation of digestive system process (GO:0060456)2.40838736
81positive regulation of Cdc42 GTPase activity (GO:0043089)2.40591014
82nucleotide salvage (GO:0043173)2.38589287
83negative regulation of cell size (GO:0045792)2.37482156
84definitive hemopoiesis (GO:0060216)2.37235861
85AMP metabolic process (GO:0046033)2.35691029
86amino sugar catabolic process (GO:0046348)2.35578203
87macrophage activation involved in immune response (GO:0002281)2.35029967
88toxin transport (GO:1901998)2.33491892
89poly(A)+ mRNA export from nucleus (GO:0016973)2.33040877
90peptide catabolic process (GO:0043171)2.32766979
91negative regulation of inclusion body assembly (GO:0090084)2.32252836
92regulation of monocyte differentiation (GO:0045655)2.30628070
93antigen processing and presentation of endogenous antigen (GO:0019883)2.30407976
94detection of other organism (GO:0098543)2.29012171
95regulation of skeletal muscle contraction (GO:0014819)2.28775142
96cellular response to thyroid hormone stimulus (GO:0097067)2.28563778
97chaperone mediated protein folding requiring cofactor (GO:0051085)2.24936130
98organelle membrane fusion (GO:0090174)2.24637737
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.24144819
100skeletal muscle adaptation (GO:0043501)2.23985162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human2.65163276
2MYC_22102868_ChIP-Seq_BL_Human2.55900568
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51629471
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.50311921
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46908188
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35838925
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33132739
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.29676672
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08806003
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97405660
11SCL_19346495_ChIP-Seq_HPC-7_Human1.89228459
12E2F7_22180533_ChIP-Seq_HELA_Human1.87637218
13EGR1_19374776_ChIP-ChIP_THP-1_Human1.82965282
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.81120350
15LXR_22292898_ChIP-Seq_THP-1_Human1.81058270
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77379913
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75686821
18VDR_24763502_ChIP-Seq_THP-1_Human1.73634722
19SPI1_23547873_ChIP-Seq_NB4_Human1.72736588
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72609075
21MAF_26560356_Chip-Seq_TH1_Human1.70947943
22TCF7_22412390_ChIP-Seq_EML_Mouse1.70064875
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67730533
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66546744
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65996221
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64738063
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61823273
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61676639
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60381607
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.60375130
31TFEB_21752829_ChIP-Seq_HELA_Human1.58425160
32KDM2B_26808549_Chip-Seq_DND41_Human1.55700960
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.51159878
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50155550
35UTX_26944678_Chip-Seq_JUKART_Human1.49394512
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49206147
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48443817
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47172618
39MAF_26560356_Chip-Seq_TH2_Human1.47158408
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.46421004
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44040479
42SPI1_23127762_ChIP-Seq_K562_Human1.42881612
43RACK7_27058665_Chip-Seq_MCF-7_Human1.42339891
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.40251642
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39383300
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.38320279
47BCL6_27268052_Chip-Seq_Bcells_Human1.37957384
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37343520
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35922394
50NCOR1_26117541_ChIP-Seq_K562_Human1.35396557
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33435452
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32944400
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31967480
54GATA1_22025678_ChIP-Seq_K562_Human1.30650559
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28953952
56P68_20966046_ChIP-Seq_HELA_Human1.28706538
57BCOR_27268052_Chip-Seq_Bcells_Human1.28203994
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27867471
59MYB_26560356_Chip-Seq_TH2_Human1.27776283
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23860883
61CTCF_21964334_Chip-Seq_Bcells_Human1.22939142
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21427403
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20783427
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20619567
65MYB_26560356_Chip-Seq_TH1_Human1.20349352
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.19343783
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18640956
68SMC4_20622854_ChIP-Seq_HELA_Human1.17224280
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.16722238
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16528738
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16007654
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15308916
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15306399
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14415482
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.13571291
76ZNF263_19887448_ChIP-Seq_K562_Human1.12989537
77CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12781317
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12761375
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10841888
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10540193
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10106353
82ATF3_27146783_Chip-Seq_COLON_Human1.10038359
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.09366057
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09324104
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08067304
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07126676
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06452458
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.06306512
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.06237333
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06044804
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05314182
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03823957
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03667211
94CLOCK_20551151_ChIP-Seq_293T_Human1.01349001
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00816909
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.00748668
97GATA1_19941826_ChIP-Seq_K562_Human1.00741505
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00287925
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00276662
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99838780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.76146541
2MP0005410_abnormal_fertilization3.24408440
3MP0009278_abnormal_bone_marrow3.16496633
4MP0003806_abnormal_nucleotide_metabolis3.08319774
5MP0002132_abnormal_respiratory_system2.80880736
6MP0004233_abnormal_muscle_weight2.51925433
7MP0008260_abnormal_autophagy2.38680627
8MP0001835_abnormal_antigen_presentation2.33281538
9MP0005397_hematopoietic_system_phenotyp2.27282981
10MP0001545_abnormal_hematopoietic_system2.27282981
11MP0003646_muscle_fatigue2.27185790
12MP0005058_abnormal_lysosome_morphology2.25261374
13MP0003303_peritoneal_inflammation2.16599772
14MP0003436_decreased_susceptibility_to1.99861381
15MP0005464_abnormal_platelet_physiology1.98572885
16MP0000749_muscle_degeneration1.76589805
17MP0005083_abnormal_biliary_tract1.73556618
18MP0003828_pulmonary_edema1.72953130
19MP0000751_myopathy1.66374808
20MP0006036_abnormal_mitochondrial_physio1.64404465
21MP0002419_abnormal_innate_immunity1.59995466
22MP0001661_extended_life_span1.51791024
23MP0003724_increased_susceptibility_to1.49697030
24MP0002332_abnormal_exercise_endurance1.48521723
25MP0009333_abnormal_splenocyte_physiolog1.47557898
26MP0005330_cardiomyopathy1.43634049
27MP0000678_abnormal_parathyroid_gland1.43165751
28MP0004087_abnormal_muscle_fiber1.40683290
29MP0005670_abnormal_white_adipose1.38229204
30MP0002269_muscular_atrophy1.38144384
31MP0003191_abnormal_cellular_cholesterol1.37974684
32MP0004484_altered_response_of1.36845855
33MP0000747_muscle_weakness1.35012253
34MP0004036_abnormal_muscle_relaxation1.34740690
35MP0004808_abnormal_hematopoietic_stem1.34598361
36MP0000750_abnormal_muscle_regeneration1.34302554
37MP0004510_myositis1.32675317
38MP0002396_abnormal_hematopoietic_system1.32192123
39MP0000759_abnormal_skeletal_muscle1.31724108
40MP0003221_abnormal_cardiomyocyte_apopto1.31162239
41MP0005000_abnormal_immune_tolerance1.31032733
42MP0000858_altered_metastatic_potential1.28657039
43MP0000343_altered_response_to1.27759362
44MP0002148_abnormal_hypersensitivity_rea1.24118107
45MP0005025_abnormal_response_to1.22776563
46MP0003656_abnormal_erythrocyte_physiolo1.22571402
47MP0002452_abnormal_antigen_presenting1.20797004
48MP0005076_abnormal_cell_differentiation1.20116192
49MP0000465_gastrointestinal_hemorrhage1.17154616
50MP0010630_abnormal_cardiac_muscle1.16717638
51MP0001849_ear_inflammation1.16300669
52MP0002723_abnormal_immune_serum1.12045001
53MP0001853_heart_inflammation1.11642112
54MP0002420_abnormal_adaptive_immunity1.10250716
55MP0001819_abnormal_immune_cell1.09954419
56MP0002398_abnormal_bone_marrow1.09192835
57MP0002722_abnormal_immune_system1.08244924
58MP0004947_skin_inflammation1.07415352
59MP0009785_altered_susceptibility_to1.07412831
60MP0004185_abnormal_adipocyte_glucose1.05579168
61MP0000685_abnormal_immune_system1.04071782
62MP0005666_abnormal_adipose_tissue1.03908632
63MP0002106_abnormal_muscle_physiology1.03384109
64MP0001533_abnormal_skeleton_physiology1.03233650
65MP0000689_abnormal_spleen_morphology1.02417149
66MP0003091_abnormal_cell_migration1.02101236
67MP0001929_abnormal_gametogenesis1.02075343
68MP0000681_abnormal_thyroid_gland0.99737953
69MP0003705_abnormal_hypodermis_morpholog0.99116177
70MP0003172_abnormal_lysosome_physiology0.97796173
71MP0009840_abnormal_foam_cell0.97030081
72MP0002127_abnormal_cardiovascular_syste0.94725040
73MP0000716_abnormal_immune_system0.94704491
74MP0002429_abnormal_blood_cell0.92569527
75MP0003698_abnormal_male_reproductive0.92475255
76MP0005164_abnormal_response_to0.92274693
77MP0005310_abnormal_salivary_gland0.91389468
78MP0002998_abnormal_bone_remodeling0.91375040
79MP0000703_abnormal_thymus_morphology0.90111138
80MP0008469_abnormal_protein_level0.89222797
81MP0003077_abnormal_cell_cycle0.89175087
82MP0005375_adipose_tissue_phenotype0.87871094
83MP0008007_abnormal_cellular_replicative0.87839646
84MP0001845_abnormal_inflammatory_respons0.87484301
85MP0010155_abnormal_intestine_physiology0.86932061
86MP0000733_abnormal_muscle_development0.86407896
87MP0005165_increased_susceptibility_to0.86359087
88MP0001800_abnormal_humoral_immune0.85742755
89MP0000003_abnormal_adipose_tissue0.84451504
90MP0002405_respiratory_system_inflammati0.84169015
91MP0003300_gastrointestinal_ulcer0.83109357
92MP0006082_CNS_inflammation0.81690757
93MP0002971_abnormal_brown_adipose0.80760865
94MP0003763_abnormal_thymus_physiology0.80737344
95MP0000490_abnormal_crypts_of0.80709242
96MP0002019_abnormal_tumor_incidence0.80668224
97MP0003111_abnormal_nucleus_morphology0.79742640
98MP0006035_abnormal_mitochondrial_morpho0.79661966
99MP0003453_abnormal_keratinocyte_physiol0.79298608
100MP0001790_abnormal_immune_system0.75850200

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)4.92612489
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.85904498
3Nemaline bodies (HP:0003798)4.71804441
4Asymmetric septal hypertrophy (HP:0001670)4.21972609
5Exercise-induced myalgia (HP:0003738)4.14513111
6Centrally nucleated skeletal muscle fibers (HP:0003687)3.96042638
7Distal lower limb muscle weakness (HP:0009053)3.78773793
8Rhabdomyolysis (HP:0003201)3.68588742
9Myoglobinuria (HP:0002913)3.63700947
10Myopathic facies (HP:0002058)3.55912019
11Loss of speech (HP:0002371)3.33774713
12Bulbar palsy (HP:0001283)3.27544469
13EMG: myopathic abnormalities (HP:0003458)3.26488416
14Rimmed vacuoles (HP:0003805)3.23169381
15Increased connective tissue (HP:0009025)3.19328559
16Fatigue (HP:0012378)3.14101456
17Distal lower limb amyotrophy (HP:0008944)3.07977918
18Ragged-red muscle fibers (HP:0003200)3.06661203
19Type 1 muscle fiber predominance (HP:0003803)2.97070937
20Exercise-induced muscle cramps (HP:0003710)2.92878984
21Abnormality of liposaccharide metabolism (HP:0010968)2.84365659
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.84365659
23Abnormality of glycolipid metabolism (HP:0010969)2.84365659
24Progressive muscle weakness (HP:0003323)2.82693462
25Nasal polyposis (HP:0100582)2.82229816
26Polycythemia (HP:0001901)2.79752490
27Vertebral compression fractures (HP:0002953)2.75353796
28Muscle fiber splitting (HP:0003555)2.67684423
29Testicular neoplasm (HP:0010788)2.56241881
30Neck muscle weakness (HP:0000467)2.54973665
31Elevated erythrocyte sedimentation rate (HP:0003565)2.54152399
32Abnormality of skeletal muscle fiber size (HP:0012084)2.51879070
33Abnormality of macrophages (HP:0004311)2.50374356
34Hyporeflexia of lower limbs (HP:0002600)2.48849060
35Abnormality of the nasal mucosa (HP:0000433)2.47616091
36Male infertility (HP:0003251)2.45586279
37Myositis (HP:0100614)2.44600284
38Difficulty climbing stairs (HP:0003551)2.44079744
39Cholecystitis (HP:0001082)2.37649629
40Abnormal gallbladder physiology (HP:0012438)2.37649629
41Gonadal dysgenesis (HP:0000133)2.36680763
42Obstructive lung disease (HP:0006536)2.31897916
43Chronic obstructive pulmonary disease (HP:0006510)2.31897916
44Increased cerebral lipofuscin (HP:0011813)2.25933768
45Cone-rod dystrophy (HP:0000548)2.24945058
46Resting tremor (HP:0002322)2.16964980
47Distal arthrogryposis (HP:0005684)2.15329955
48Muscle stiffness (HP:0003552)2.14161292
49Ulnar deviation of the wrist (HP:0003049)2.08935536
50Upper motor neuron abnormality (HP:0002127)2.08920794
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.08018960
52Absent/shortened dynein arms (HP:0200106)2.08018960
53Gastrointestinal inflammation (HP:0004386)2.07586018
54Hepatosplenomegaly (HP:0001433)2.01021883
55Shoulder girdle muscle weakness (HP:0003547)2.00984283
56Hypertensive crisis (HP:0100735)1.99830030
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98435714
58Aplasia/Hypoplasia of the thymus (HP:0010515)1.97293279
59Mediastinal lymphadenopathy (HP:0100721)1.96429172
60Recurrent abscess formation (HP:0002722)1.95379950
61Prolonged bleeding time (HP:0003010)1.94144681
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94079483
63Easy fatigability (HP:0003388)1.93567727
64Increased neuronal autofluorescent lipopigment (HP:0002074)1.93409510
65Ventricular tachycardia (HP:0004756)1.92226759
66Increased variability in muscle fiber diameter (HP:0003557)1.91926596
67Colitis (HP:0002583)1.91117109
68Increased serum ferritin (HP:0003281)1.91083670
69Abnormality of lateral ventricle (HP:0030047)1.89834589
70Epistaxis (HP:0000421)1.88668756
71Malignant hyperthermia (HP:0002047)1.88356292
72Inflammation of the large intestine (HP:0002037)1.87649203
73Abnormal large intestine physiology (HP:0012700)1.83220737
74Hypertriglyceridemia (HP:0002155)1.83147079
75Muscle hypertrophy of the lower extremities (HP:0008968)1.82927208
76Foot dorsiflexor weakness (HP:0009027)1.82734511
77Bowel incontinence (HP:0002607)1.82160663
78Reduced antithrombin III activity (HP:0001976)1.82028377
79Eczematoid dermatitis (HP:0000976)1.81863890
80Scapular winging (HP:0003691)1.81612585
81Severe visual impairment (HP:0001141)1.81476209
82Chest pain (HP:0100749)1.78414836
83Pelvic girdle muscle weakness (HP:0003749)1.75748780
84Short nail (HP:0001799)1.74478658
85Trismus (HP:0000211)1.74404299
86Mildly elevated creatine phosphokinase (HP:0008180)1.74056051
87Areflexia of lower limbs (HP:0002522)1.73517538
88Orchitis (HP:0100796)1.73177502
89Petechiae (HP:0000967)1.72887953
90Multiple enchondromatosis (HP:0005701)1.72512029
91Achilles tendon contracture (HP:0001771)1.71652768
92Difficulty running (HP:0009046)1.71000819
93Acute hepatic failure (HP:0006554)1.70654941
94Abnormality of the costochondral junction (HP:0000919)1.70297920
95Purpura (HP:0000979)1.69377498
96Granulocytopenia (HP:0001913)1.68896226
97Cellulitis (HP:0100658)1.68684970
98Generalized muscle weakness (HP:0003324)1.68202729
99Thrombocytosis (HP:0001894)1.66682512
100Abnormality of the foot musculature (HP:0001436)1.65111338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K34.00243132
2PBK3.43378477
3SCYL22.99921551
4IRAK32.71148913
5PLK42.60047582
6TRIB32.57208619
7ERN12.49722236
8NME22.35556975
9TTN2.35371809
10OBSCN2.31255808
11TESK12.01442984
12TBK12.00279765
13PRPF4B1.75151288
14CCNB11.72366205
15MAP4K11.67513321
16RIPK41.64747987
17TESK21.59316971
18MAP3K141.58256274
19MAP3K131.56936254
20MAP3K11.52301128
21TAOK21.51761533
22SMG11.46962206
23TAOK31.41700681
24MAP3K31.40765396
25MAP3K61.37862243
26NEK91.33394050
27ICK1.30955612
28MOS1.30792941
29PAK41.29792121
30ARAF1.24292078
31MAP3K111.22551738
32JAK31.21550734
33ZAP701.10490110
34EPHB11.06922798
35KSR21.06784428
36CDK41.05434926
37PDPK11.05097336
38PIK3CG1.04856531
39IRAK41.04735302
40RPS6KB21.03096877
41TGFBR21.02619469
42EPHA21.00583571
43GRK60.98594391
44BMPR20.97955247
45BCKDK0.95528298
46MST1R0.94957399
47IRAK20.91940209
48MAP2K60.85039805
49TNK20.85029591
50TYK20.84587278
51CDK70.83297587
52VRK20.81720332
53MAP3K50.80970752
54KIT0.79864854
55BLK0.78875565
56CDK120.77507974
57DDR20.76171784
58PRKD30.74696324
59PDK10.74400781
60MAP2K40.73883339
61NEK60.73652735
62IKBKB0.67474584
63STK100.67048351
64PIM20.66881284
65MARK30.65189799
66BTK0.64547744
67RPS6KC10.63461489
68RPS6KL10.63461489
69SIK10.63295230
70MAP3K80.62879325
71AKT20.62837125
72PKN20.61756735
73FLT30.61136574
74CSF1R0.59695310
75TAOK10.59496778
76MAPK70.58914334
77CDK60.58524965
78STK380.57682010
79FGR0.56899569
80CSK0.56723332
81IKBKE0.55451055
82BMX0.54740794
83MAP2K20.54224176
84MTOR0.53401298
85PDK20.52404502
86EIF2AK10.48420542
87PTK60.45434768
88CDK80.45003499
89MAPK110.44714744
90RET0.44251081
91MAP3K70.42880113
92RPS6KA40.42479030
93MAPK120.41218037
94PAK10.41161638
95SIK30.41003016
96RPS6KA60.40225659
97DYRK1B0.39924244
98MATK0.38571460
99PRKG20.37925584
100MAPKAPK30.35019003

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.52441558
2Pentose phosphate pathway_Homo sapiens_hsa000302.37768507
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.16145522
4Acute myeloid leukemia_Homo sapiens_hsa052211.93366170
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87991459
6Osteoclast differentiation_Homo sapiens_hsa043801.86180305
7Leishmaniasis_Homo sapiens_hsa051401.82855682
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76796888
9DNA replication_Homo sapiens_hsa030301.71395956
10Lysosome_Homo sapiens_hsa041421.69357574
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62890200
12Carbon metabolism_Homo sapiens_hsa012001.61100340
13Fructose and mannose metabolism_Homo sapiens_hsa000511.60588619
14B cell receptor signaling pathway_Homo sapiens_hsa046621.56080988
15Base excision repair_Homo sapiens_hsa034101.51340900
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49510648
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44356402
18Legionellosis_Homo sapiens_hsa051341.40970512
19Influenza A_Homo sapiens_hsa051641.37961317
20Fatty acid biosynthesis_Homo sapiens_hsa000611.35414661
21Shigellosis_Homo sapiens_hsa051311.34842486
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.31516853
23Tuberculosis_Homo sapiens_hsa051521.30064764
24TNF signaling pathway_Homo sapiens_hsa046681.29372567
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29206674
26Antigen processing and presentation_Homo sapiens_hsa046121.26729649
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26447733
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25038330
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.22818427
30Herpes simplex infection_Homo sapiens_hsa051681.21528580
31Biosynthesis of amino acids_Homo sapiens_hsa012301.20957212
32Pyrimidine metabolism_Homo sapiens_hsa002401.20858655
33Pancreatic cancer_Homo sapiens_hsa052121.20301469
34Viral myocarditis_Homo sapiens_hsa054161.19214517
35Toxoplasmosis_Homo sapiens_hsa051451.17048010
36Chronic myeloid leukemia_Homo sapiens_hsa052201.15098346
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12876289
38Non-small cell lung cancer_Homo sapiens_hsa052231.12768521
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.11008929
40Apoptosis_Homo sapiens_hsa042101.07044135
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98780219
42Bladder cancer_Homo sapiens_hsa052190.97879736
43Galactose metabolism_Homo sapiens_hsa000520.97338783
44Hepatitis B_Homo sapiens_hsa051610.97300213
45VEGF signaling pathway_Homo sapiens_hsa043700.95778499
46Measles_Homo sapiens_hsa051620.95320443
47Platelet activation_Homo sapiens_hsa046110.94865446
48Epstein-Barr virus infection_Homo sapiens_hsa051690.94313642
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.92675637
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92497235
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90735306
52Insulin signaling pathway_Homo sapiens_hsa049100.88508605
53RNA transport_Homo sapiens_hsa030130.88225561
54N-Glycan biosynthesis_Homo sapiens_hsa005100.87583970
55Fatty acid elongation_Homo sapiens_hsa000620.86178911
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.85932912
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85761784
58Glutathione metabolism_Homo sapiens_hsa004800.83143168
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82903661
60Insulin resistance_Homo sapiens_hsa049310.82230787
61Viral carcinogenesis_Homo sapiens_hsa052030.82046344
62Endocytosis_Homo sapiens_hsa041440.81873164
63Thyroid cancer_Homo sapiens_hsa052160.80995049
64HTLV-I infection_Homo sapiens_hsa051660.80585169
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80539290
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.80075300
67HIF-1 signaling pathway_Homo sapiens_hsa040660.79134582
68Renal cell carcinoma_Homo sapiens_hsa052110.78967311
69Hematopoietic cell lineage_Homo sapiens_hsa046400.78554596
70Spliceosome_Homo sapiens_hsa030400.77891333
71mTOR signaling pathway_Homo sapiens_hsa041500.77305261
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76013860
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.75178095
74Salmonella infection_Homo sapiens_hsa051320.74416018
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73667803
76Hepatitis C_Homo sapiens_hsa051600.72004606
77Phenylalanine metabolism_Homo sapiens_hsa003600.71191673
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69231148
79Nucleotide excision repair_Homo sapiens_hsa034200.68976781
80Allograft rejection_Homo sapiens_hsa053300.68487682
81Inositol phosphate metabolism_Homo sapiens_hsa005620.67760590
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.67236518
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65808199
84Staphylococcus aureus infection_Homo sapiens_hsa051500.63404901
85Phagosome_Homo sapiens_hsa041450.62823560
86Malaria_Homo sapiens_hsa051440.61845173
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61766231
88mRNA surveillance pathway_Homo sapiens_hsa030150.59985843
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59834724
90Fanconi anemia pathway_Homo sapiens_hsa034600.58154955
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55994530
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55375842
93T cell receptor signaling pathway_Homo sapiens_hsa046600.55025058
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.54407856
95Endometrial cancer_Homo sapiens_hsa052130.53710396
96Prolactin signaling pathway_Homo sapiens_hsa049170.53020796
97Notch signaling pathway_Homo sapiens_hsa043300.52395620
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.51170197
99Graft-versus-host disease_Homo sapiens_hsa053320.50742761
100Pertussis_Homo sapiens_hsa051330.49232844

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