ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	artery smooth muscle contraction (GO:0014824)	6.20695831
2	daunorubicin metabolic process (GO:0044597)	5.88548039
3	polyketide metabolic process (GO:0030638)	5.88548039
4	doxorubicin metabolic process (GO:0044598)	5.88548039
5	tonic smooth muscle contraction (GO:0014820)	5.43464747
6	aminoglycoside antibiotic metabolic process (GO:0030647)	5.19852192
7	prostanoid biosynthetic process (GO:0046457)	5.04751571
8	prostaglandin biosynthetic process (GO:0001516)	5.04751571
9	nucleotide-sugar biosynthetic process (GO:0009226)	4.59821588
10	cobalamin metabolic process (GO:0009235)	4.26753330
11	ribosome assembly (GO:0042255)	4.22779676
12	prostanoid metabolic process (GO:0006692)	4.16874566
13	prostaglandin metabolic process (GO:0006693)	4.16874566
14	xenobiotic catabolic process (GO:0042178)	4.15961319
15	desmosome organization (GO:0002934)	4.11897327
16	cyclooxygenase pathway (GO:0019371)	4.04603197
17	establishment of integrated proviral latency (GO:0075713)	3.99890129
18	GDP-mannose metabolic process (GO:0019673)	3.96091434
19	proteasome assembly (GO:0043248)	3.86800364
20	establishment of viral latency (GO:0019043)	3.84212247
21	glycoside metabolic process (GO:0016137)	3.75174080
22	protein retention in ER lumen (GO:0006621)	3.69856606
23	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.54043292
24	energy homeostasis (GO:0097009)	3.52281730
25	digestion (GO:0007586)	3.52215618
26	female gonad development (GO:0008585)	3.42280188
27	regulation of cellular amino acid metabolic process (GO:0006521)	3.41272960
28	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.39988574
29	inositol phosphate-mediated signaling (GO:0048016)	3.35681405
30	quinone metabolic process (GO:1901661)	3.29762971
31	intestinal epithelial cell development (GO:0060576)	3.27462098
32	interferon-gamma secretion (GO:0072643)	3.26209125
33	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.20555814
34	regulation of mitochondrial translation (GO:0070129)	3.19672977
35	vascular smooth muscle contraction (GO:0014829)	3.12207304
36	fatty acid elongation (GO:0030497)	3.10282838
37	glutathione derivative biosynthetic process (GO:1901687)	3.07419020
38	glutathione derivative metabolic process (GO:1901685)	3.07419020
39	peroxisome fission (GO:0016559)	3.05372602
40	epoxygenase P450 pathway (GO:0019373)	3.02000763
41	primary alcohol catabolic process (GO:0034310)	3.01035984
42	macrophage chemotaxis (GO:0048246)	2.95541150
43	negative regulation of epidermal cell differentiation (GO:0045605)	2.95527361
44	axon ensheathment in central nervous system (GO:0032291)	2.95195198
45	central nervous system myelination (GO:0022010)	2.95195198
46	positive regulation of cellular amine metabolic process (GO:0033240)	2.92312825
47	phenylpropanoid metabolic process (GO:0009698)	2.91033330
48	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.90808898
49	diterpenoid biosynthetic process (GO:0016102)	2.90769362
50	NADH metabolic process (GO:0006734)	2.90697944
51	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.89915068
52	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.89418836
53	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84158338
54	mitotic nuclear envelope reassembly (GO:0007084)	2.83276614
55	nuclear envelope reassembly (GO:0031468)	2.83276614
56	negative regulation of keratinocyte proliferation (GO:0010839)	2.82115220
57	positive regulation of pseudopodium assembly (GO:0031274)	2.81623631
58	protein maturation by protein folding (GO:0022417)	2.81528502
59	otic vesicle formation (GO:0030916)	2.80998281
60	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.78800043
61	COPI coating of Golgi vesicle (GO:0048205)	2.77328958
62	Golgi transport vesicle coating (GO:0048200)	2.77328958
63	nucleotide-sugar metabolic process (GO:0009225)	2.76222207
64	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.73696733
65	regulation of cardioblast differentiation (GO:0051890)	2.72963618
66	regulation of cellular amine metabolic process (GO:0033238)	2.68748923
67	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.67099604
68	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.67099604
69	regulation of keratinocyte proliferation (GO:0010837)	2.66945300
70	membrane budding (GO:0006900)	2.66752667
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.65180709
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.65180709
73	glycolipid catabolic process (GO:0019377)	2.64706552
74	intestinal cholesterol absorption (GO:0030299)	2.63949499
75	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.63378403
76	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.63378403
77	endocrine process (GO:0050886)	2.63378403
78	intestinal absorption (GO:0050892)	2.62512925
79	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.61488642
80	negative regulation of ligase activity (GO:0051352)	2.60689133
81	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.60689133
82	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.60246346
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.60246346
84	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.60246346
85	nucleoside diphosphate biosynthetic process (GO:0009133)	2.60041328
86	nucleobase-containing small molecule interconversion (GO:0015949)	2.59584665
87	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.58111363
88	positive regulation of actin filament depolymerization (GO:0030836)	2.56976049
89	glucuronate metabolic process (GO:0019585)	2.54556889
90	uronic acid metabolic process (GO:0006063)	2.54556889
91	parturition (GO:0007567)	2.53334636
92	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.53272295
93	regulation of guanylate cyclase activity (GO:0031282)	2.52384967
94	lipopolysaccharide biosynthetic process (GO:0009103)	2.51021111
95	renal system process involved in regulation of blood volume (GO:0001977)	2.50622585
96	cellular glucuronidation (GO:0052695)	2.49354137
97	polyamine biosynthetic process (GO:0006596)	2.48691357
98	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.48203634
99	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.47783009
100	phasic smooth muscle contraction (GO:0014821)	2.47467587

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.40350512
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.34810055
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.49335090
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.41413285
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02548214
6	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.87791739
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.82032360
8	DCP1A_22483619_ChIP-Seq_HELA_Human	2.70376988
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.68362775
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.64473762
11	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.48955878
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.36500029
13	ZNF263_19887448_ChIP-Seq_K562_Human	2.36313957
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.25878174
15	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.24161063
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22893008
17	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.20968219
18	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.18182757
19	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.15880575
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.09727994
21	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.04441773
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.97928689
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.93299407
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90846767
25	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.90356828
26	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.87807633
27	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.83645167
28	GATA4_25053715_ChIP-Seq_YYC3_Human	1.83356232
29	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.82277599
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80393400
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78199024
32	AR_21909140_ChIP-Seq_LNCAP_Human	1.78151004
33	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.78053369
34	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.78015932
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.77236407
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.74080026
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.73635366
38	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.71486400
39	GATA6_25053715_ChIP-Seq_YYC3_Human	1.70353444
40	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.66590284
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.66534520
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62353714
43	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.59408197
44	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.56556183
45	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54796657
46	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.53916204
47	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.51641567
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.50066919
49	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.44077207
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.43573400
51	SOX2_20726797_ChIP-Seq_SW620_Human	1.42706305
52	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.38986404
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.34773679
54	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.34292246
55	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.33386383
56	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.33386383
57	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.30149893
58	ATF3_27146783_Chip-Seq_COLON_Human	1.29763634
59	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.29219906
60	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.28615940
61	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.26263978
62	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.25799726
63	ELF5_23300383_ChIP-Seq_T47D_Human	1.21950237
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21395403
65	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.20528487
66	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.20503859
67	EOMES_21245162_ChIP-Seq_HESCs_Human	1.19006882
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.18428925
69	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.18169154
70	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17971986
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17544352
72	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.17370758
73	RACK7_27058665_Chip-Seq_MCF-7_Human	1.16620407
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.16420315
75	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.15438904
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.13583323
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.12450435
78	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11282005
79	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10253394
80	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.09158628
81	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.07522609
82	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.06385095
83	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.05848935
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05750731
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.03199829
86	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.01186817
87	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.01107175
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.00503232
89	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.00241296
90	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.99429221
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.98438970
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97548407
93	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.94697119
94	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.92578923
95	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91148964
96	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.90436865
97	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90041732
98	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.89858855
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.88947106
100	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.88378792

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001666_abnormal_nutrient_absorption	4.03627905
2	MP0010234_abnormal_vibrissa_follicle	3.60407303
3	MP0002822_catalepsy	3.42828258
4	MP0002796_impaired_skin_barrier	3.42527893
5	MP0004264_abnormal_extraembryonic_tissu	3.41470033
6	MP0005360_urolithiasis	3.09597587
7	MP0003693_abnormal_embryo_hatching	2.80719665
8	MP0003806_abnormal_nucleotide_metabolis	2.76982625
9	MP0000537_abnormal_urethra_morphology	2.63437815
10	MP0005646_abnormal_pituitary_gland	2.42351559
11	MP0005501_abnormal_skin_physiology	2.40593747
12	MP0003123_paternal_imprinting	2.36640840
13	MP0005365_abnormal_bile_salt	2.32564681
14	MP0003718_maternal_effect	2.30918985
15	MP0003315_abnormal_perineum_morphology	2.22541515
16	MP0000566_synostosis	2.19197612
17	MP0001529_abnormal_vocalization	2.06702122
18	MP0001727_abnormal_embryo_implantation	2.00941736
19	MP0008260_abnormal_autophagy	1.99541742
20	MP0010030_abnormal_orbit_morphology	1.99405348
21	MP0003191_abnormal_cellular_cholesterol	1.99207445
22	MP0008875_abnormal_xenobiotic_pharmacok	1.96088641
23	MP0009840_abnormal_foam_cell	1.93600291
24	MP0003950_abnormal_plasma_membrane	1.76379794
25	MP0004957_abnormal_blastocyst_morpholog	1.75728157
26	MP0010678_abnormal_skin_adnexa	1.73274360
27	MP0001905_abnormal_dopamine_level	1.62712906
28	MP0004019_abnormal_vitamin_homeostasis	1.61047124
29	MP0009697_abnormal_copulation	1.60612462
30	MP0004147_increased_porphyrin_level	1.60184144
31	MP0000383_abnormal_hair_follicle	1.58408746
32	MP0002098_abnormal_vibrissa_morphology	1.57263391
33	MP0000647_abnormal_sebaceous_gland	1.55882367
34	MP0000538_abnormal_urinary_bladder	1.54808141
35	MP0005083_abnormal_biliary_tract	1.53995449
36	MP0001919_abnormal_reproductive_system	1.43830900
37	MP0010386_abnormal_urinary_bladder	1.41526583
38	MP0005367_renal/urinary_system_phenotyp	1.40707903
39	MP0000516_abnormal_urinary_system	1.40707903
40	MP0000627_abnormal_mammary_gland	1.37720269
41	MP0008872_abnormal_physiological_respon	1.35851903
42	MP0000462_abnormal_digestive_system	1.34480807
43	MP0009780_abnormal_chondrocyte_physiolo	1.32530049
44	MP0005332_abnormal_amino_acid	1.29961593
45	MP0001764_abnormal_homeostasis	1.24930822
46	MP0002139_abnormal_hepatobiliary_system	1.24796622
47	MP0008932_abnormal_embryonic_tissue	1.20903829
48	MP0000747_muscle_weakness	1.19311996
49	MP0003186_abnormal_redox_activity	1.17332519
50	MP0010771_integument_phenotype	1.14906525
51	MP0003868_abnormal_feces_composition	1.12578538
52	MP0005085_abnormal_gallbladder_physiolo	1.10381661
53	MP0001216_abnormal_epidermal_layer	1.09020721
54	MP0003936_abnormal_reproductive_system	1.07511636
55	MP0000762_abnormal_tongue_morphology	1.07216893
56	MP0004782_abnormal_surfactant_physiolog	1.05488984
57	MP0000427_abnormal_hair_cycle	1.03635071
58	MP0003941_abnormal_skin_development	1.02291268
59	MP0003880_abnormal_central_pattern	0.99780306
60	MP0005670_abnormal_white_adipose	0.97645914
61	MP0000490_abnormal_crypts_of	0.94258272
62	MP0001765_abnormal_ion_homeostasis	0.93912083
63	MP0006035_abnormal_mitochondrial_morpho	0.92862143
64	MP0004272_abnormal_basement_membrane	0.91828762
65	MP0004270_analgesia	0.91674761
66	MP0000467_abnormal_esophagus_morphology	0.88417370
67	MP0000377_abnormal_hair_follicle	0.88359772
68	MP0003938_abnormal_ear_development	0.85671589
69	MP0002277_abnormal_respiratory_mucosa	0.85615788
70	MP0010352_gastrointestinal_tract_polyps	0.83904527
71	MP0005636_abnormal_mineral_homeostasis	0.83616791
72	MP0008058_abnormal_DNA_repair	0.83138815
73	MP0001730_embryonic_growth_arrest	0.82747286
74	MP0000477_abnormal_intestine_morphology	0.81471745
75	MP0005451_abnormal_body_composition	0.80062836
76	MP0006036_abnormal_mitochondrial_physio	0.78274126
77	MP0000613_abnormal_salivary_gland	0.78031790
78	MP0009643_abnormal_urine_homeostasis	0.76624448
79	MP0003878_abnormal_ear_physiology	0.76047974
80	MP0005377_hearing/vestibular/ear_phenot	0.76047974
81	MP0000920_abnormal_myelination	0.73642925
82	MP0005389_reproductive_system_phenotype	0.73182099
83	MP0002210_abnormal_sex_determination	0.70120340
84	MP0008775_abnormal_heart_ventricle	0.69379963
85	MP0005395_other_phenotype	0.69362857
86	MP0005408_hypopigmentation	0.67765292
87	MP0001664_abnormal_digestion	0.65875585
88	MP0006276_abnormal_autonomic_nervous	0.65787257
89	MP0005257_abnormal_intraocular_pressure	0.64806743
90	MP0003329_amyloid_beta_deposits	0.63906767
91	MP0003077_abnormal_cell_cycle	0.63815850
92	MP0010329_abnormal_lipoprotein_level	0.63402452
93	MP0001145_abnormal_male_reproductive	0.62184161
94	MP0000534_abnormal_ureter_morphology	0.61743169
95	MP0001346_abnormal_lacrimal_gland	0.61452962
96	MP0002653_abnormal_ependyma_morphology	0.60652586
97	MP0005410_abnormal_fertilization	0.60629778
98	MP0003699_abnormal_female_reproductive	0.60027782
99	MP0005319_abnormal_enzyme/_coenzyme	0.58953992
100	MP0001881_abnormal_mammary_gland	0.58744115

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatic necrosis (HP:0002605)	4.11421889
2	Hepatocellular necrosis (HP:0001404)	3.83619262
3	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.68743522
4	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.68743522
5	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.60664824
6	Hypoglycemic coma (HP:0001325)	3.49607394
7	Steatorrhea (HP:0002570)	3.37600161
8	Hydroxyprolinuria (HP:0003080)	3.30138798
9	Abnormality of proline metabolism (HP:0010907)	3.30138798
10	Vascular calcification (HP:0004934)	3.27765010
11	Tetraparesis (HP:0002273)	3.17020134
12	Proximal tubulopathy (HP:0000114)	3.01673827
13	Abnormality of the corticospinal tract (HP:0002492)	3.01479315
14	Right ventricular cardiomyopathy (HP:0011663)	2.95840909
15	Type I transferrin isoform profile (HP:0003642)	2.95397245
16	Generalized aminoaciduria (HP:0002909)	2.91391911
17	Pili torti (HP:0003777)	2.89698682
18	Mitochondrial inheritance (HP:0001427)	2.89122314
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88786688
20	Microvesicular hepatic steatosis (HP:0001414)	2.85041919
21	Acute necrotizing encephalopathy (HP:0006965)	2.81717863
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.78843291
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.78843291
24	Cardiovascular calcification (HP:0011915)	2.75751973
25	Fat malabsorption (HP:0002630)	2.75281272
26	Increased CSF lactate (HP:0002490)	2.74689273
27	Glycosuria (HP:0003076)	2.73644741
28	Abnormality of urine glucose concentration (HP:0011016)	2.73644741
29	Upper limb muscle weakness (HP:0003484)	2.73460258
30	Nausea (HP:0002018)	2.71142378
31	Alacrima (HP:0000522)	2.70686110
32	Limb-girdle muscle atrophy (HP:0003797)	2.68912696
33	CNS demyelination (HP:0007305)	2.65568784
34	Acute encephalopathy (HP:0006846)	2.63276324
35	Reduced antithrombin III activity (HP:0001976)	2.59892530
36	Paraparesis (HP:0002385)	2.55103356
37	Secondary amenorrhea (HP:0000869)	2.49687846
38	Increased serum lactate (HP:0002151)	2.47258646
39	Microretrognathia (HP:0000308)	2.42567403
40	Vertebral compression fractures (HP:0002953)	2.42253707
41	Micronodular cirrhosis (HP:0001413)	2.41447488
42	Rough bone trabeculation (HP:0100670)	2.40539418
43	Microglossia (HP:0000171)	2.40382593
44	Shoulder girdle muscle weakness (HP:0003547)	2.39508177
45	Decreased lacrimation (HP:0000633)	2.37992544
46	Distal lower limb muscle weakness (HP:0009053)	2.36129708
47	Sparse eyelashes (HP:0000653)	2.33246506
48	Lethargy (HP:0001254)	2.29125855
49	Glucose intolerance (HP:0000833)	2.28006241
50	Progressive macrocephaly (HP:0004481)	2.26394734
51	Emotional lability (HP:0000712)	2.24826158
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.21391882
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.21391882
54	Abnormal protein glycosylation (HP:0012346)	2.21391882
55	Abnormal glycosylation (HP:0012345)	2.21391882
56	Lactic acidosis (HP:0003128)	2.19029004
57	Termporal pattern (HP:0011008)	2.19022957
58	Insidious onset (HP:0003587)	2.19022957
59	Cerebral hypomyelination (HP:0006808)	2.18512358
60	Congenital ichthyosiform erythroderma (HP:0007431)	2.17286150
61	Tongue fasciculations (HP:0001308)	2.15783645
62	Prolonged neonatal jaundice (HP:0006579)	2.14202614
63	Leukodystrophy (HP:0002415)	2.14111800
64	Oral leukoplakia (HP:0002745)	2.13804094
65	Lipid accumulation in hepatocytes (HP:0006561)	2.13555001
66	Scanning speech (HP:0002168)	2.13167690
67	Abnormal trabecular bone morphology (HP:0100671)	2.12786430
68	Opisthotonus (HP:0002179)	2.11506709
69	Renal cortical cysts (HP:0000803)	2.10652969
70	Short nail (HP:0001799)	2.08623780
71	Adrenal hypoplasia (HP:0000835)	2.07907469
72	Cerebral edema (HP:0002181)	2.07818384
73	Abnormality of the hip-girdle musculature (HP:0001445)	2.05257393
74	Abnormality of the musculature of the pelvis (HP:0001469)	2.05257393
75	Distal lower limb amyotrophy (HP:0008944)	2.04384817
76	Autoamputation (HP:0001218)	2.03859223
77	Abnormality of magnesium homeostasis (HP:0004921)	2.03775542
78	Alopecia of scalp (HP:0002293)	2.03310438
79	Amelogenesis imperfecta (HP:0000705)	1.98036124
80	CNS hypomyelination (HP:0003429)	1.98006098
81	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.97590241
82	Abnormal hair laboratory examination (HP:0003328)	1.95654019
83	Abnormality of fatty-acid metabolism (HP:0004359)	1.95053135
84	Stenosis of the external auditory canal (HP:0000402)	1.91644381
85	Dicarboxylic aciduria (HP:0003215)	1.90459702
86	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.90459702
87	Pelvic girdle muscle weakness (HP:0003749)	1.90343806
88	Respiratory failure (HP:0002878)	1.89629466
89	Increased muscle lipid content (HP:0009058)	1.89581253
90	Confusion (HP:0001289)	1.88436952
91	Hypoglycemic seizures (HP:0002173)	1.88137809
92	Exercise intolerance (HP:0003546)	1.86554429
93	Late onset (HP:0003584)	1.86486600
94	Hyperammonemia (HP:0001987)	1.85880361
95	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.85661535
96	Morphological abnormality of the pyramidal tract (HP:0002062)	1.85630610
97	Spastic paraparesis (HP:0002313)	1.83503798
98	Ureteral duplication (HP:0000073)	1.82884097
99	Abnormality of renal resorption (HP:0011038)	1.82813112
100	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82514232

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	6.29500499
2	MST4	4.06135212
3	PBK	4.00971101
4	TESK1	3.35950283
5	VRK2	3.25746541
6	PDK2	2.87486687
7	TESK2	2.51347946
8	MST1R	2.36517355
9	NME2	2.33321338
10	LIMK1	2.20892888
11	MAP3K12	2.06304298
12	TRIM28	1.81104924
13	STK39	1.70939706
14	TNIK	1.67318294
15	MAPKAPK3	1.62754732
16	BCR	1.62127652
17	SCYL2	1.58232905
18	STK16	1.56754326
19	NEK1	1.52202721
20	RPS6KB2	1.51255972
21	PAK4	1.49949159
22	MET	1.48568242
23	LMTK2	1.47331209
24	MYLK	1.45094816
25	EIF2AK1	1.40663610
26	WNK3	1.35013668
27	DAPK1	1.31070122
28	ILK	1.30283060
29	SIK3	1.24841824
30	EIF2AK3	1.24780892
31	EPHB2	1.23440032
32	BUB1	1.23077880
33	MAP2K7	1.22377475
34	DAPK3	1.17163065
35	TLK1	1.13620230
36	NEK2	1.12693832
37	OXSR1	1.10620835
38	PRKCI	1.09690387
39	CAMK2G	1.02535090
40	CASK	1.01196461
41	NME1	0.96420456
42	PAK2	0.94593470
43	ERBB4	0.92768454
44	FER	0.92746146
45	LATS2	0.91696890
46	TSSK6	0.89320315
47	BCKDK	0.87650050
48	ABL2	0.87624528
49	SRPK1	0.84038339
50	EPHA4	0.83825150
51	PIM2	0.83750271
52	VRK1	0.75695626
53	PTK2	0.71798148
54	AURKB	0.71580301
55	RPS6KA4	0.71351568
56	WEE1	0.70106521
57	SIK1	0.67351223
58	PRKG2	0.66867651
59	CAMK2B	0.66601687
60	CAMK2D	0.65456215
61	STK10	0.65245513
62	GRK1	0.65010826
63	PAK1	0.64455442
64	ARAF	0.62761376
65	AKT2	0.61923406
66	ZAK	0.61527987
67	IRAK3	0.61162011
68	STK38L	0.59532163
69	PLK1	0.59049035
70	MAP3K3	0.58040145
71	PTK2B	0.54404626
72	AURKA	0.54324457
73	PHKG1	0.51892873
74	PHKG2	0.51892873
75	CCNB1	0.51864547
76	CSNK1G3	0.50809953
77	CSNK1A1	0.50318126
78	GRK5	0.47953991
79	INSRR	0.45554584
80	CSNK1A1L	0.44898475
81	MAP3K8	0.44646621
82	SMG1	0.42689896
83	ERN1	0.42686029
84	PRKCE	0.41320843
85	NUAK1	0.39476057
86	DMPK	0.37950137
87	ROCK2	0.37186313
88	MAP2K2	0.35982482
89	CDK7	0.35153676
90	TBK1	0.34551085
91	ERBB3	0.33623492
92	EIF2AK2	0.33608387
93	CSNK1G2	0.32093085
94	BMPR1B	0.30629638
95	EGFR	0.30611989
96	NEK6	0.29931681
97	CSNK2A2	0.28734573
98	TAOK2	0.28402051
99	STK38	0.28224961
100	PTK6	0.28123329

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.74674928
2	Sulfur relay system_Homo sapiens_hsa04122	3.40441046
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.57949000
4	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.45463445
5	Fat digestion and absorption_Homo sapiens_hsa04975	2.42444710
6	Folate biosynthesis_Homo sapiens_hsa00790	2.35269598
7	Glutathione metabolism_Homo sapiens_hsa00480	2.21489721
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.17538255
9	Fatty acid elongation_Homo sapiens_hsa00062	2.10572526
10	Pancreatic secretion_Homo sapiens_hsa04972	2.07051169
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.96479227
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.89180710
13	Sulfur metabolism_Homo sapiens_hsa00920	1.87586774
14	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.82306888
15	Protein digestion and absorption_Homo sapiens_hsa04974	1.80834565
16	Vibrio cholerae infection_Homo sapiens_hsa05110	1.74910107
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.72391353
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.69645481
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.62723426
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.60528547
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.58630515
22	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.58178667
23	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.53439895
24	Parkinsons disease_Homo sapiens_hsa05012	1.46739351
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.46584722
26	Arginine and proline metabolism_Homo sapiens_hsa00330	1.45183348
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.44282795
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.40442097
29	Pentose phosphate pathway_Homo sapiens_hsa00030	1.39658825
30	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.39063831
31	Galactose metabolism_Homo sapiens_hsa00052	1.37225295
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34300022
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.30995381
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.29945518
35	Histidine metabolism_Homo sapiens_hsa00340	1.26653773
36	Carbon metabolism_Homo sapiens_hsa01200	1.26164724
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.20283775
38	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.16831388
39	Protein export_Homo sapiens_hsa03060	1.15994534
40	Glycerolipid metabolism_Homo sapiens_hsa00561	1.15970888
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12560523
42	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.09033537
43	Huntingtons disease_Homo sapiens_hsa05016	1.06280799
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02033621
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00371328
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99549074
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99421183
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98134893
49	RNA polymerase_Homo sapiens_hsa03020	0.97175734
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.96924834
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96196667
52	Arginine biosynthesis_Homo sapiens_hsa00220	0.94250750
53	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.92638447
54	Renin-angiotensin system_Homo sapiens_hsa04614	0.91302756
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89996914
56	DNA replication_Homo sapiens_hsa03030	0.89118766
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88636604
58	Alzheimers disease_Homo sapiens_hsa05010	0.87120322
59	Peroxisome_Homo sapiens_hsa04146	0.86044219
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85747478
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85234787
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85162058
63	Metabolic pathways_Homo sapiens_hsa01100	0.85119567
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83711537
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.83643667
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82495476
67	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.81836369
68	Mineral absorption_Homo sapiens_hsa04978	0.79821753
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.77780967
70	Tight junction_Homo sapiens_hsa04530	0.77609742
71	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.75886139
72	Mismatch repair_Homo sapiens_hsa03430	0.73091936
73	RNA transport_Homo sapiens_hsa03013	0.71370147
74	Base excision repair_Homo sapiens_hsa03410	0.69380303
75	Purine metabolism_Homo sapiens_hsa00230	0.68426316
76	Propanoate metabolism_Homo sapiens_hsa00640	0.66533222
77	Ribosome_Homo sapiens_hsa03010	0.66465283
78	Retinol metabolism_Homo sapiens_hsa00830	0.65965695
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.64231238
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.60224394
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.60220999
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60013611
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57017871
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56005298
85	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55010699
86	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51495491
87	Fatty acid degradation_Homo sapiens_hsa00071	0.51426985
88	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.51317997
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47302317
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47108866
91	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.46847180
92	Thyroid cancer_Homo sapiens_hsa05216	0.45522006
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44737545
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.44543243
95	Bile secretion_Homo sapiens_hsa04976	0.43622041
96	Spliceosome_Homo sapiens_hsa03040	0.43185986
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.42553304
98	Lysosome_Homo sapiens_hsa04142	0.41332861
99	Homologous recombination_Homo sapiens_hsa03440	0.34952252
100	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30875068

KRT8P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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