KRT8P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)4.92405992
2regulation of mitochondrial translation (GO:0070129)4.88856794
3proteasome assembly (GO:0043248)4.80865211
4COPI coating of Golgi vesicle (GO:0048205)4.42916182
5Golgi transport vesicle coating (GO:0048200)4.42916182
6protein retention in ER lumen (GO:0006621)4.38857057
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.37149295
8cell adhesion mediated by integrin (GO:0033627)3.72025252
9regulation of cellular amino acid metabolic process (GO:0006521)3.69010224
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60718756
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58982738
12GDP-mannose metabolic process (GO:0019673)3.58824901
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53145956
14L-phenylalanine metabolic process (GO:0006558)3.53145956
15GTP biosynthetic process (GO:0006183)3.44662942
16UTP biosynthetic process (GO:0006228)3.42911581
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37385521
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36900386
19negative regulation of ligase activity (GO:0051352)3.36900386
20regulation of metalloenzyme activity (GO:0048552)3.36507679
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32739413
22negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.26732171
23ribosome assembly (GO:0042255)3.26564289
24nucleotide-sugar biosynthetic process (GO:0009226)3.22051345
25signal transduction involved in DNA damage checkpoint (GO:0072422)3.19016449
26signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19016449
27mitotic nuclear envelope reassembly (GO:0007084)3.18303454
28nuclear envelope reassembly (GO:0031468)3.18303454
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14828228
30artery smooth muscle contraction (GO:0014824)3.14081529
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13055888
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13055888
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.11307465
34desmosome organization (GO:0002934)3.10347204
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08670222
36signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08670222
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08670222
38ribosome biogenesis (GO:0042254)3.07942946
39tonic smooth muscle contraction (GO:0014820)3.07503496
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06109601
41UTP metabolic process (GO:0046051)3.03367735
42xenobiotic catabolic process (GO:0042178)3.02825203
43prostaglandin biosynthetic process (GO:0001516)3.02701960
44prostanoid biosynthetic process (GO:0046457)3.02701960
45basement membrane organization (GO:0071711)3.01794587
46nucleobase-containing small molecule interconversion (GO:0015949)3.00946936
47glutamine family amino acid biosynthetic process (GO:0009084)2.99475600
48guanosine-containing compound biosynthetic process (GO:1901070)2.99393184
49pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.95369186
50pyrimidine-containing compound transmembrane transport (GO:0072531)2.94209083
51positive regulation of ligase activity (GO:0051351)2.94107344
52CTP metabolic process (GO:0046036)2.93808830
53CTP biosynthetic process (GO:0006241)2.93808830
54ER overload response (GO:0006983)2.92261095
55pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91907151
56negative regulation of B cell apoptotic process (GO:0002903)2.89570168
57ribosomal large subunit biogenesis (GO:0042273)2.89457695
58regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.86058030
59cobalamin metabolic process (GO:0009235)2.85887758
60protein heterotetramerization (GO:0051290)2.85205418
61formation of translation preinitiation complex (GO:0001731)2.85038290
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77972758
63mitotic metaphase plate congression (GO:0007080)2.77340759
64positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.76156602
65endothelial cell morphogenesis (GO:0001886)2.74611947
66atrioventricular valve morphogenesis (GO:0003181)2.71539711
67galactose catabolic process (GO:0019388)2.70770531
68calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.70455647
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69567550
70pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.68733847
71regulation of cardioblast differentiation (GO:0051890)2.68585267
72actin filament depolymerization (GO:0030042)2.68162477
73establishment of integrated proviral latency (GO:0075713)2.68038180
74pteridine-containing compound biosynthetic process (GO:0042559)2.67198847
75positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.66719675
76water-soluble vitamin biosynthetic process (GO:0042364)2.66151771
77regulation of cellular amine metabolic process (GO:0033238)2.65429007
78pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.65323540
79regulation of ubiquitin-protein transferase activity (GO:0051438)2.65137853
80mitotic sister chromatid segregation (GO:0000070)2.64650183
81positive regulation of osteoblast proliferation (GO:0033690)2.63847158
82skin morphogenesis (GO:0043589)2.61136728
83doxorubicin metabolic process (GO:0044598)2.61127098
84daunorubicin metabolic process (GO:0044597)2.61127098
85polyketide metabolic process (GO:0030638)2.61127098
86regulation of gonadotropin secretion (GO:0032276)2.60468181
87DNA unwinding involved in DNA replication (GO:0006268)2.60460219
88positive regulation of cell cycle arrest (GO:0071158)2.60184584
89pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.57213718
90regulation of ligase activity (GO:0051340)2.56844894
91tRNA methylation (GO:0030488)2.56213844
92pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.55984213
93nucleoside transmembrane transport (GO:1901642)2.55632741
94pseudouridine synthesis (GO:0001522)2.55440371
95response to gravity (GO:0009629)2.55076275
96pentose-phosphate shunt (GO:0006098)2.54201504
97ncRNA 3-end processing (GO:0043628)2.51718409
98positive regulation of pseudopodium assembly (GO:0031274)2.50772234
99dicarboxylic acid biosynthetic process (GO:0043650)2.50260453
100pentose metabolic process (GO:0019321)2.48190101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.02752613
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.48192794
3E2F7_22180533_ChIP-Seq_HELA_Human3.33076704
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21022219
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11890740
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.83732225
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80682748
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72901899
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64665481
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64537175
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61535197
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50639394
13AR_21909140_ChIP-Seq_LNCAP_Human2.41124329
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.37229389
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36367557
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30385579
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20026721
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13792537
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.12049944
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05458656
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04353525
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.01881124
23HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.01724907
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01071272
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99830460
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99087155
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.91070742
28DCP1A_22483619_ChIP-Seq_HELA_Human1.88878553
29ZNF263_19887448_ChIP-Seq_K562_Human1.80514096
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.76565981
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74198892
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73244944
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70196515
34GABP_19822575_ChIP-Seq_HepG2_Human1.68414412
35XRN2_22483619_ChIP-Seq_HELA_Human1.65821186
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.65483800
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64506647
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64001719
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59683326
40ATF3_27146783_Chip-Seq_COLON_Human1.59366315
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55753034
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54018641
43* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.51426310
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50975620
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50922302
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50631805
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50631805
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.50482228
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49190395
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48681376
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46522708
52RACK7_27058665_Chip-Seq_MCF-7_Human1.41990277
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40478119
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.40099523
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38922669
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38545756
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34778853
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34187103
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32798398
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31326324
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.31320365
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.29236908
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27412360
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.25280991
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25135928
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24694514
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.23988722
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.21075162
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20958220
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.20874253
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19026983
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19025964
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17393182
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17060701
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16694961
76GATA6_25053715_ChIP-Seq_YYC3_Human1.15990078
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15885232
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.14341167
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10706684
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10531436
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09999655
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09607886
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.08915484
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08612144
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07836350
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04085491
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04028144
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03739148
89TTF2_22483619_ChIP-Seq_HELA_Human1.03616283
90GATA4_25053715_ChIP-Seq_YYC3_Human1.03294612
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02744940
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01112362
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.00436017
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00286370
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.00188588
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99795220
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98902544
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94799273
99TP53_22127205_ChIP-Seq_IMR90_Human0.94658047
100KDM5A_27292631_Chip-Seq_BREAST_Human0.93875226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.54429044
2MP0003950_abnormal_plasma_membrane3.81733831
3MP0008438_abnormal_cutaneous_collagen3.51683044
4MP0000537_abnormal_urethra_morphology3.10511961
5MP0005360_urolithiasis3.08526040
6MP0010352_gastrointestinal_tract_polyps3.07819350
7MP0004272_abnormal_basement_membrane2.63785191
8MP0003566_abnormal_cell_adhesion2.57408374
9MP0001853_heart_inflammation2.34387958
10MP0008875_abnormal_xenobiotic_pharmacok2.26274588
11MP0003693_abnormal_embryo_hatching2.21221174
12MP0002877_abnormal_melanocyte_morpholog2.19935674
13MP0005451_abnormal_body_composition2.01664715
14MP0001666_abnormal_nutrient_absorption1.81442122
15MP0002796_impaired_skin_barrier1.80181166
16MP0000751_myopathy1.77969706
17MP0004957_abnormal_blastocyst_morpholog1.74549086
18MP0005058_abnormal_lysosome_morphology1.72395155
19MP0003806_abnormal_nucleotide_metabolis1.67592048
20MP0010030_abnormal_orbit_morphology1.66988124
21MP0005623_abnormal_meninges_morphology1.64439727
22MP0002060_abnormal_skin_morphology1.62229509
23MP0005023_abnormal_wound_healing1.61146062
24MP0006054_spinal_hemorrhage1.58265858
25MP0010386_abnormal_urinary_bladder1.56811665
26MP0000462_abnormal_digestive_system1.52014161
27MP0002163_abnormal_gland_morphology1.50783118
28MP0005501_abnormal_skin_physiology1.50687091
29MP0005670_abnormal_white_adipose1.45047109
30MP0003191_abnormal_cellular_cholesterol1.42220651
31MP0005365_abnormal_bile_salt1.41744575
32MP0003315_abnormal_perineum_morphology1.37929142
33MP0001958_emphysema1.37673450
34MP0000647_abnormal_sebaceous_gland1.36855639
35MP0005257_abnormal_intraocular_pressure1.36705897
36MP0000538_abnormal_urinary_bladder1.34358178
37MP0001661_extended_life_span1.32280295
38MP0009780_abnormal_chondrocyte_physiolo1.23226746
39MP0000613_abnormal_salivary_gland1.22744088
40MP0004782_abnormal_surfactant_physiolog1.22644538
41MP0009697_abnormal_copulation1.22021282
42MP0005083_abnormal_biliary_tract1.21250071
43MP0003300_gastrointestinal_ulcer1.20414237
44MP0004233_abnormal_muscle_weight1.18998170
45MP0008260_abnormal_autophagy1.17716011
46MP0008932_abnormal_embryonic_tissue1.16334203
47MP0003111_abnormal_nucleus_morphology1.16021171
48MP0003786_premature_aging1.15591572
49MP0001216_abnormal_epidermal_layer1.14419199
50MP0001730_embryonic_growth_arrest1.13322207
51MP0001849_ear_inflammation1.10448953
52MP0002139_abnormal_hepatobiliary_system1.10324803
53MP0003705_abnormal_hypodermis_morpholog1.09554367
54MP0000749_muscle_degeneration1.06201747
55MP0005084_abnormal_gallbladder_morpholo1.06043293
56MP0003941_abnormal_skin_development1.05189061
57MP0000467_abnormal_esophagus_morphology1.04305777
58MP0009840_abnormal_foam_cell1.04101934
59MP0003123_paternal_imprinting1.03058456
60MP0010771_integument_phenotype1.01499579
61MP0005330_cardiomyopathy1.00426554
62MP0004185_abnormal_adipocyte_glucose0.99720168
63MP0003718_maternal_effect0.98165113
64MP0002098_abnormal_vibrissa_morphology0.97951531
65MP0004264_abnormal_extraembryonic_tissu0.97704566
66MP0000358_abnormal_cell_content/0.94608254
67MP0009384_cardiac_valve_regurgitation0.94214682
68MP0000490_abnormal_crypts_of0.91656537
69MP0010094_abnormal_chromosome_stability0.89681188
70MP0010678_abnormal_skin_adnexa0.89444362
71MP0000534_abnormal_ureter_morphology0.88755474
72MP0008775_abnormal_heart_ventricle0.88647740
73MP0000858_altered_metastatic_potential0.87970485
74MP0002089_abnormal_postnatal_growth/wei0.86515140
75MP0005319_abnormal_enzyme/_coenzyme0.86514784
76MP0003077_abnormal_cell_cycle0.83307675
77MP0001542_abnormal_bone_strength0.82735958
78MP0003453_abnormal_keratinocyte_physiol0.82699921
79MP0001243_abnormal_dermal_layer0.80005934
80MP0009053_abnormal_anal_canal0.79176255
81MP0000604_amyloidosis0.78900514
82MP0005165_increased_susceptibility_to0.78802550
83MP0000747_muscle_weakness0.78332196
84MP0002080_prenatal_lethality0.77331440
85MP0000627_abnormal_mammary_gland0.76087364
86MP0001529_abnormal_vocalization0.75260947
87MP0002837_dystrophic_cardiac_calcinosis0.74487998
88MP0001764_abnormal_homeostasis0.73866248
89MP0001672_abnormal_embryogenesis/_devel0.73252605
90MP0005380_embryogenesis_phenotype0.73252605
91MP0005332_abnormal_amino_acid0.72979699
92MP0001756_abnormal_urination0.72819392
93MP0001697_abnormal_embryo_size0.72478113
94MP0008007_abnormal_cellular_replicative0.72208395
95MP0002086_abnormal_extraembryonic_tissu0.71151148
96MP0005395_other_phenotype0.70953492
97MP0005220_abnormal_exocrine_pancreas0.70161388
98MP0000465_gastrointestinal_hemorrhage0.69874201
99MP0003646_muscle_fatigue0.69041168
100MP0001727_abnormal_embryo_implantation0.68475996

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.50235348
2Vascular calcification (HP:0004934)4.46821202
3Cardiovascular calcification (HP:0011915)4.29991267
4Cutaneous melanoma (HP:0012056)4.15628406
5Back pain (HP:0003418)3.42960724
6Trismus (HP:0000211)3.15207722
7Micronodular cirrhosis (HP:0001413)3.07898203
8Vertebral compression fractures (HP:0002953)2.98903414
9Reduced subcutaneous adipose tissue (HP:0003758)2.92126083
10Short nail (HP:0001799)2.84125398
11Limb-girdle muscle atrophy (HP:0003797)2.81827539
12Distal upper limb amyotrophy (HP:0007149)2.74420600
13Upper limb amyotrophy (HP:0009129)2.74420600
14Abnormality of the Achilles tendon (HP:0005109)2.71954273
15Distal lower limb muscle weakness (HP:0009053)2.68452644
16Abnormality of the distal phalanges of the toes (HP:0010182)2.65954672
17Ankle contracture (HP:0006466)2.63084998
18Glucose intolerance (HP:0000833)2.62629774
19Hand muscle atrophy (HP:0009130)2.60180251
20Sparse eyelashes (HP:0000653)2.57338752
21Abnormality of the umbilical cord (HP:0010881)2.54607287
22Rough bone trabeculation (HP:0100670)2.53795600
23J-shaped sella turcica (HP:0002680)2.47122022
24Generalized amyotrophy (HP:0003700)2.46331667
25Mildly elevated creatine phosphokinase (HP:0008180)2.42490337
26Microvesicular hepatic steatosis (HP:0001414)2.41713531
27Ileus (HP:0002595)2.41513448
28Abnormality of placental membranes (HP:0011409)2.41193856
29Amniotic constriction ring (HP:0009775)2.41193856
30Achilles tendon contracture (HP:0001771)2.41018689
31Distal lower limb amyotrophy (HP:0008944)2.38908803
32Abnormalities of placenta or umbilical cord (HP:0001194)2.38216277
33Ureteral duplication (HP:0000073)2.37313539
34Spastic diplegia (HP:0001264)2.33515963
35Increased serum pyruvate (HP:0003542)2.33259869
36Abnormality of glycolysis (HP:0004366)2.31410855
37Congenital ichthyosiform erythroderma (HP:0007431)2.29837305
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29447324
39Protrusio acetabuli (HP:0003179)2.22950914
40Follicular hyperkeratosis (HP:0007502)2.22627551
41Intrahepatic cholestasis (HP:0001406)2.21936474
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18957685
43Popliteal pterygium (HP:0009756)2.16619645
44Hyperammonemia (HP:0001987)2.16473587
45Renal tubular acidosis (HP:0001947)2.15566684
46Acanthosis nigricans (HP:0000956)2.13675477
47Type I transferrin isoform profile (HP:0003642)2.13352481
48Osteolytic defects of the hand bones (HP:0009699)2.12178995
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.12178995
50Mitral stenosis (HP:0001718)2.10904431
51Upper limb muscle weakness (HP:0003484)2.10593522
52Elbow flexion contracture (HP:0002987)2.10225727
53Hyperglycinemia (HP:0002154)2.10088760
54Prolonged neonatal jaundice (HP:0006579)2.09732712
55Entropion (HP:0000621)2.08938590
56Spastic paraparesis (HP:0002313)2.04051143
57Abnormal trabecular bone morphology (HP:0100671)2.01714675
58Hypokinesia (HP:0002375)2.01206338
59Right ventricular cardiomyopathy (HP:0011663)2.00340813
60Lipid accumulation in hepatocytes (HP:0006561)1.99021247
61Unilateral renal agenesis (HP:0000122)1.95891144
62Hepatocellular carcinoma (HP:0001402)1.95403286
63Abdominal distention (HP:0003270)1.95111851
64Cervical subluxation (HP:0003308)1.87455022
65Subacute progressive viral hepatitis (HP:0006572)1.85768088
66Microretrognathia (HP:0000308)1.85059323
67Progressive sensorineural hearing impairment (HP:0000408)1.84556338
68Aortic dissection (HP:0002647)1.83673855
69Testicular atrophy (HP:0000029)1.83582054
70Paraparesis (HP:0002385)1.83073064
71Decreased subcutaneous fat (HP:0001002)1.82909842
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82419849
73Spinal rigidity (HP:0003306)1.82044396
74Aplasia of the musculature (HP:0100854)1.81641923
75Abnormality of subcutaneous fat tissue (HP:0001001)1.81322064
76Renal Fanconi syndrome (HP:0001994)1.80587972
77Shoulder girdle muscle weakness (HP:0003547)1.79431110
78Opisthotonus (HP:0002179)1.79201043
79Hypoalphalipoproteinemia (HP:0003233)1.77781560
80Vacuolated lymphocytes (HP:0001922)1.76074129
81Atrophic scars (HP:0001075)1.75851170
82Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75490489
83Fragile skin (HP:0001030)1.74872851
84Fat malabsorption (HP:0002630)1.73498853
85Slender build (HP:0001533)1.73490048
86Sparse lateral eyebrow (HP:0005338)1.72951142
87Abnormal mitochondria in muscle tissue (HP:0008316)1.71388349
88Increased hepatocellular lipid droplets (HP:0006565)1.71310518
89Gastrointestinal dysmotility (HP:0002579)1.71005202
90Parakeratosis (HP:0001036)1.71000883
91Difficulty climbing stairs (HP:0003551)1.70451863
92Insulin resistance (HP:0000855)1.70212503
93Increased connective tissue (HP:0009025)1.70072415
94Deep venous thrombosis (HP:0002625)1.70008334
95Hypolipoproteinemia (HP:0010981)1.69272623
96Ulnar deviation of the wrist (HP:0003049)1.69216754
97Pterygium (HP:0001059)1.69185762
98Pelvic girdle muscle weakness (HP:0003749)1.69037908
99Abnormal glycosylation (HP:0012345)1.67726092
100Abnormal protein N-linked glycosylation (HP:0012347)1.67726092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.55788010
2LMTK24.02629888
3BUB13.60611624
4MST1R3.20750859
5PBK3.13022660
6PAK43.06252990
7TLK12.95398191
8TESK12.84712258
9NME22.84013629
10ZAK2.78254017
11SMG12.55543481
12VRK22.53721042
13LIMK12.26902832
14MYLK1.99577010
15IRAK31.99451414
16MAP3K121.89579989
17TESK21.83776480
18PDK21.77991501
19SCYL21.68034395
20MET1.63992302
21ERN11.56248749
22RPS6KB21.52406263
23VRK11.46811324
24PTK21.37457586
25MST41.33100368
26NEK11.28384319
27AURKA1.23586615
28EIF2AK11.17492307
29BCKDK1.14311684
30DAPK31.13937309
31ABL21.07807964
32MAP3K81.03052363
33MAP3K31.01370135
34AURKB1.00607551
35SIK11.00263214
36CSNK1A1L0.99712913
37CDK90.98687256
38CSNK1G30.95745274
39TIE10.93360452
40PRKG20.93192039
41CDK80.92123560
42MAPKAPK30.91697496
43ILK0.89050526
44PIM20.88486033
45ERBB40.87512968
46STK100.84885024
47AKT20.83138843
48DAPK10.81367220
49FER0.79362816
50CAMK2G0.79248316
51PTK60.78773648
52STK40.78276955
53PLK10.78266680
54EPHB20.74637080
55CCNB10.73205819
56PAK10.69836105
57ROCK10.68626435
58STK160.67215887
59RPS6KA50.65767087
60CDK70.62184464
61TTN0.58269810
62MAP4K20.57904536
63ICK0.56776410
64TAOK20.56384538
65NEK20.55559059
66PRKCI0.54725050
67NME10.53747762
68EIF2AK30.51602905
69LATS20.51574144
70MUSK0.51367294
71CSNK1G10.51054034
72WEE10.49923887
73CAMK2D0.49700487
74MAP3K130.49238675
75TAF10.47706028
76MELK0.46418275
77SRPK10.46307417
78FGFR40.45446355
79MOS0.44904763
80TTK0.43830162
81CSNK1G20.41960768
82MAP2K20.41567443
83PLK30.41228093
84PAK20.41181780
85MAP2K70.40507073
86EIF2AK20.38573956
87BRSK10.38433071
88CAMK2B0.38420752
89CHEK20.37748594
90GRK10.36221066
91CHUK0.35928424
92LATS10.33643381
93ARAF0.33613246
94CDC70.31211713
95TSSK60.30951301
96ROCK20.30231425
97MAP2K10.29687735
98PRKD30.27893946
99STK390.27740196
100MAP3K110.25701192

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.63615301
2Sulfur metabolism_Homo sapiens_hsa009203.02963229
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90676891
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73267538
5DNA replication_Homo sapiens_hsa030302.39035663
6Systemic lupus erythematosus_Homo sapiens_hsa053222.36977030
7Sulfur relay system_Homo sapiens_hsa041222.25422468
8Glutathione metabolism_Homo sapiens_hsa004802.11393582
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05064841
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00671862
11Arginine biosynthesis_Homo sapiens_hsa002201.91017992
12Fatty acid elongation_Homo sapiens_hsa000621.88627804
13Pyrimidine metabolism_Homo sapiens_hsa002401.85998043
14Biosynthesis of amino acids_Homo sapiens_hsa012301.81831678
15Vibrio cholerae infection_Homo sapiens_hsa051101.79533907
16Alcoholism_Homo sapiens_hsa050341.78424115
17Pentose phosphate pathway_Homo sapiens_hsa000301.76958207
18Base excision repair_Homo sapiens_hsa034101.74487153
19Carbon metabolism_Homo sapiens_hsa012001.73823645
20Folate biosynthesis_Homo sapiens_hsa007901.60122679
21N-Glycan biosynthesis_Homo sapiens_hsa005101.57712355
22Fructose and mannose metabolism_Homo sapiens_hsa000511.57454666
23Nucleotide excision repair_Homo sapiens_hsa034201.53871089
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50866937
25Galactose metabolism_Homo sapiens_hsa000521.47883312
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47564655
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.46444673
28RNA polymerase_Homo sapiens_hsa030201.41256187
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37799687
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36709678
31Mismatch repair_Homo sapiens_hsa034301.34000562
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33213553
33Vitamin digestion and absorption_Homo sapiens_hsa049771.23165131
34Fat digestion and absorption_Homo sapiens_hsa049751.19499497
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18003561
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17311998
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.17309738
38Oxidative phosphorylation_Homo sapiens_hsa001901.13140298
39Pyruvate metabolism_Homo sapiens_hsa006201.12461854
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.08769658
41Spliceosome_Homo sapiens_hsa030401.08108739
42Other glycan degradation_Homo sapiens_hsa005111.04874395
43Arginine and proline metabolism_Homo sapiens_hsa003301.03410174
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01590854
45RNA transport_Homo sapiens_hsa030130.95878565
46Phenylalanine metabolism_Homo sapiens_hsa003600.93301659
47Viral carcinogenesis_Homo sapiens_hsa052030.90901390
48Ribosome_Homo sapiens_hsa030100.90462669
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89770947
50One carbon pool by folate_Homo sapiens_hsa006700.89710944
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89490095
52Steroid biosynthesis_Homo sapiens_hsa001000.86279148
53Renin-angiotensin system_Homo sapiens_hsa046140.84348215
54Protein digestion and absorption_Homo sapiens_hsa049740.84335697
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81802288
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81720488
57Tight junction_Homo sapiens_hsa045300.80844701
58Huntingtons disease_Homo sapiens_hsa050160.79682616
59ECM-receptor interaction_Homo sapiens_hsa045120.77047364
60Thyroid cancer_Homo sapiens_hsa052160.76154750
61Parkinsons disease_Homo sapiens_hsa050120.74769051
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74185116
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.73536219
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72236398
65Peroxisome_Homo sapiens_hsa041460.71736757
66Cell cycle_Homo sapiens_hsa041100.71511082
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71242020
68Nitrogen metabolism_Homo sapiens_hsa009100.69058505
69Purine metabolism_Homo sapiens_hsa002300.68910435
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68239424
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67533180
72Metabolic pathways_Homo sapiens_hsa011000.66678383
73Bladder cancer_Homo sapiens_hsa052190.65150937
74Selenocompound metabolism_Homo sapiens_hsa004500.63939851
75Tyrosine metabolism_Homo sapiens_hsa003500.63394258
76Hippo signaling pathway_Homo sapiens_hsa043900.62881218
77Basal transcription factors_Homo sapiens_hsa030220.60956006
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57241466
79p53 signaling pathway_Homo sapiens_hsa041150.56490358
80Homologous recombination_Homo sapiens_hsa034400.56353998
81Fatty acid metabolism_Homo sapiens_hsa012120.54493019
82Alzheimers disease_Homo sapiens_hsa050100.54405786
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.52606542
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52022177
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50832560
86Fatty acid biosynthesis_Homo sapiens_hsa000610.50738135
87Chemical carcinogenesis_Homo sapiens_hsa052040.50582124
88Fatty acid degradation_Homo sapiens_hsa000710.50244691
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47135138
90Starch and sucrose metabolism_Homo sapiens_hsa005000.45560009
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45285600
92Lysosome_Homo sapiens_hsa041420.44155211
93Pancreatic secretion_Homo sapiens_hsa049720.43100538
94Focal adhesion_Homo sapiens_hsa045100.41898275
95Fanconi anemia pathway_Homo sapiens_hsa034600.40299880
96TGF-beta signaling pathway_Homo sapiens_hsa043500.40275449
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.39293053
98Non-homologous end-joining_Homo sapiens_hsa034500.38993151
99Protein export_Homo sapiens_hsa030600.38656959
100Glycerolipid metabolism_Homo sapiens_hsa005610.38369139

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