KRT8P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1platelet dense granule organization (GO:0060155)7.47611442
2fucose metabolic process (GO:0006004)7.18244836
3fucosylation (GO:0036065)7.09785797
4female mating behavior (GO:0060180)6.65099628
5mitochondrial fragmentation involved in apoptotic process (GO:0043653)5.91242981
6cell wall macromolecule catabolic process (GO:0016998)5.85377528
7cellular response to interferon-beta (GO:0035458)5.24686105
8multicellular organismal reproductive behavior (GO:0033057)4.93787931
9response to pheromone (GO:0019236)4.92013952
10cell wall macromolecule metabolic process (GO:0044036)4.84779769
11mannose metabolic process (GO:0006013)4.78754858
12urinary tract smooth muscle contraction (GO:0014848)4.76449355
13cellular ketone body metabolic process (GO:0046950)4.72295233
14L-fucose catabolic process (GO:0042355)4.70968815
15fucose catabolic process (GO:0019317)4.70968815
16L-fucose metabolic process (GO:0042354)4.70968815
17positive regulation of mRNA catabolic process (GO:0061014)4.68571971
18proline transport (GO:0015824)4.59528779
19inositol phosphate-mediated signaling (GO:0048016)4.58263796
20tachykinin receptor signaling pathway (GO:0007217)4.54647413
21neuron remodeling (GO:0016322)4.41338043
22endosome to pigment granule transport (GO:0043485)4.20720089
23endosome to melanosome transport (GO:0035646)4.20720089
24regulation of RIG-I signaling pathway (GO:0039535)4.20047389
25mitotic cell cycle arrest (GO:0071850)4.17059676
26ketone body metabolic process (GO:1902224)4.15550614
27cellular response to nicotine (GO:0071316)4.04807516
28carnitine shuttle (GO:0006853)4.03878076
29fatty acid elongation (GO:0030497)4.02478793
30fatty acid transmembrane transport (GO:1902001)4.01560889
31regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.99177964
32maternal behavior (GO:0042711)3.98630878
33regulation of pigment cell differentiation (GO:0050932)3.94326847
34DNA strand renaturation (GO:0000733)3.93421836
35regulation of mRNA catabolic process (GO:0061013)3.92246629
36response to methylmercury (GO:0051597)3.90097384
37GDP-mannose metabolic process (GO:0019673)3.89820473
38parental behavior (GO:0060746)3.89414778
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.87603983
40melanosome organization (GO:0032438)3.86519096
41regulation of glucokinase activity (GO:0033131)3.84191029
42regulation of hexokinase activity (GO:1903299)3.84191029
43anterograde synaptic vesicle transport (GO:0048490)3.74225963
44cellular response to dsRNA (GO:0071359)3.71283020
45cellular response to exogenous dsRNA (GO:0071360)3.66366114
46regulation of histone deacetylation (GO:0031063)3.64626558
47positive regulation of guanylate cyclase activity (GO:0031284)3.61839685
48outer ear morphogenesis (GO:0042473)3.57578997
49pigment granule organization (GO:0048753)3.56484577
50multi-organism reproductive behavior (GO:0044705)3.52799968
51inner mitochondrial membrane organization (GO:0007007)3.46810212
52positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.42591257
53lipopolysaccharide biosynthetic process (GO:0009103)3.39964953
54carnitine transmembrane transport (GO:1902603)3.39189299
55C4-dicarboxylate transport (GO:0015740)3.37914802
56thrombin receptor signaling pathway (GO:0070493)3.35963058
57regulation of guanylate cyclase activity (GO:0031282)3.35709076
58positive regulation of action potential (GO:0045760)3.32584843
59negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.32131435
60mitochondrion degradation (GO:0000422)3.30576620
61type B pancreatic cell proliferation (GO:0044342)3.29461245
62secretory granule organization (GO:0033363)3.28996493
63positive regulation of digestive system process (GO:0060456)3.26486115
64alanine transport (GO:0032328)3.25717691
65reproductive behavior (GO:0019098)3.25208593
66behavioral response to nicotine (GO:0035095)3.24323568
67heparin biosynthetic process (GO:0030210)3.23279242
68heparin metabolic process (GO:0030202)3.23279242
69alkaloid metabolic process (GO:0009820)3.23278545
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.21276000
71aggressive behavior (GO:0002118)3.20145456
72arginine catabolic process (GO:0006527)3.14819875
73mitochondrial fission (GO:0000266)3.11916257
74amino-acid betaine transport (GO:0015838)3.08405978
75carnitine transport (GO:0015879)3.08405978
76glutamate receptor signaling pathway (GO:0007215)3.07642880
77response to insecticide (GO:0017085)2.98463666
78cellular anion homeostasis (GO:0030002)2.90957263
79regulation of developmental pigmentation (GO:0048070)2.89428860
80lipopolysaccharide metabolic process (GO:0008653)2.84511913
81protein autoprocessing (GO:0016540)2.83944463
82response to interferon-beta (GO:0035456)2.83657582
83ADP metabolic process (GO:0046031)2.83533931
84photoreceptor cell maintenance (GO:0045494)2.82929731
85positive regulation of vascular permeability (GO:0043117)2.77518680
86positive regulation of interferon-alpha production (GO:0032727)2.76892569
87tyrosine metabolic process (GO:0006570)2.71419033
88protein import into peroxisome matrix (GO:0016558)2.71103396
89phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.70106999
90cellular response to alkaloid (GO:0071312)2.69797124
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68878758
92positive regulation of uterine smooth muscle contraction (GO:0070474)2.67490287
93nephron epithelium morphogenesis (GO:0072088)2.67397345
94nephron tubule morphogenesis (GO:0072078)2.67397345
95regulation of interferon-alpha production (GO:0032647)2.64109760
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.62954889
97positive regulation of histone deacetylation (GO:0031065)2.59712503
98replication fork processing (GO:0031297)2.59058157
99behavioral response to ethanol (GO:0048149)2.58594372
100nonmotile primary cilium assembly (GO:0035058)2.58464507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.23987439
2GBX2_23144817_ChIP-Seq_PC3_Human3.67059123
3VDR_22108803_ChIP-Seq_LS180_Human3.48862244
4TAF15_26573619_Chip-Seq_HEK293_Human3.17621865
5ZNF274_21170338_ChIP-Seq_K562_Hela3.11561340
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23154134
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14661975
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.05364542
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02123871
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00774258
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.00774258
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00025889
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97854537
14TCF4_22108803_ChIP-Seq_LS180_Human1.93500260
15TP53_22573176_ChIP-Seq_HFKS_Human1.92911368
16EWS_26573619_Chip-Seq_HEK293_Human1.84490682
17DROSHA_22980978_ChIP-Seq_HELA_Human1.82309101
18P300_19829295_ChIP-Seq_ESCs_Human1.81249905
19BCAT_22108803_ChIP-Seq_LS180_Human1.79824958
20STAT3_23295773_ChIP-Seq_U87_Human1.74376034
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66322145
22FUS_26573619_Chip-Seq_HEK293_Human1.63126893
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62828191
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.61813438
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61431879
26ER_23166858_ChIP-Seq_MCF-7_Human1.60493863
27REST_21632747_ChIP-Seq_MESCs_Mouse1.60051486
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50711418
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49278055
30IRF1_19129219_ChIP-ChIP_H3396_Human1.48331629
31AR_25329375_ChIP-Seq_VCAP_Human1.47185536
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46893836
33E2F7_22180533_ChIP-Seq_HELA_Human1.46558281
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46248214
35SMAD4_21799915_ChIP-Seq_A2780_Human1.42374958
36KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37910055
37TP53_16413492_ChIP-PET_HCT116_Human1.37664142
38RNF2_27304074_Chip-Seq_NSC_Mouse1.34299577
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33237864
40CBP_20019798_ChIP-Seq_JUKART_Human1.32707309
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32707309
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32307813
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31960249
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31960249
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30738271
46TCF4_23295773_ChIP-Seq_U87_Human1.29793992
47RXR_22108803_ChIP-Seq_LS180_Human1.29457179
48CDX2_22108803_ChIP-Seq_LS180_Human1.28688866
49EZH2_22144423_ChIP-Seq_EOC_Human1.27511568
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27358156
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26906753
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25584472
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.25440294
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25195272
55RUNX2_22187159_ChIP-Seq_PCA_Human1.24443109
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23830973
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22912497
58SOX2_19829295_ChIP-Seq_ESCs_Human1.22881429
59NANOG_19829295_ChIP-Seq_ESCs_Human1.22881429
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19608732
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17796542
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17660758
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.17382430
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17245175
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17185606
66AR_21572438_ChIP-Seq_LNCaP_Human1.15821524
67JUN_21703547_ChIP-Seq_K562_Human1.15796163
68NANOG_20526341_ChIP-Seq_ESCs_Human1.15023472
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.12230427
70P53_22387025_ChIP-Seq_ESCs_Mouse1.10720250
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.10623878
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10426128
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09386979
74ERA_21632823_ChIP-Seq_H3396_Human1.08891288
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06185605
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.05020930
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03518395
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02943083
79HOXB7_26014856_ChIP-Seq_BT474_Human1.02163856
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00501407
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00338262
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.00013543
83SMAD4_21741376_ChIP-Seq_EPCs_Human0.99930986
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99073266
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.98523054
86OCT4_20526341_ChIP-Seq_ESCs_Human0.97520964
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95405320
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.95114673
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94902117
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94847464
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94081633
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93294772
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92025274
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.91536344
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91525814
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91473464
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90927207
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.89675442
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89675442
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89418246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.37369774
2MP0001968_abnormal_touch/_nociception3.97746640
3MP0003195_calcinosis3.63906717
4MP0002254_reproductive_system_inflammat3.48027733
5MP0000569_abnormal_digit_pigmentation3.33812103
6MP0008875_abnormal_xenobiotic_pharmacok3.32088838
7MP0002736_abnormal_nociception_after3.29925888
8MP0000015_abnormal_ear_pigmentation3.22985597
9MP0002837_dystrophic_cardiac_calcinosis3.14265730
10MP0002876_abnormal_thyroid_physiology2.71139238
11MP0005174_abnormal_tail_pigmentation2.69088498
12MP0001188_hyperpigmentation2.48091856
13MP0005167_abnormal_blood-brain_barrier2.46476674
14MP0002735_abnormal_chemical_nociception2.42320690
15MP0005409_darkened_coat_color2.24470342
16MP0009046_muscle_twitch2.21264643
17MP0004885_abnormal_endolymph2.18200845
18MP0006054_spinal_hemorrhage2.10154404
19MP0004142_abnormal_muscle_tone2.04017014
20MP0004264_abnormal_extraembryonic_tissu1.97932294
21MP0005551_abnormal_eye_electrophysiolog1.89134336
22MP0001529_abnormal_vocalization1.82025893
23MP0005310_abnormal_salivary_gland1.78926670
24MP0009697_abnormal_copulation1.73635135
25MP0000383_abnormal_hair_follicle1.68674176
26MP0002272_abnormal_nervous_system1.67491529
27MP0000013_abnormal_adipose_tissue1.62605813
28MP0002653_abnormal_ependyma_morphology1.58652351
29MP0002095_abnormal_skin_pigmentation1.57854741
30MP0009745_abnormal_behavioral_response1.54836194
31MP0008877_abnormal_DNA_methylation1.52492679
32MP0003646_muscle_fatigue1.52050722
33MP0005647_abnormal_sex_gland1.45188705
34MP0003718_maternal_effect1.44601467
35MP0010386_abnormal_urinary_bladder1.44468880
36MP0003656_abnormal_erythrocyte_physiolo1.40053772
37MP0004924_abnormal_behavior1.35273139
38MP0005386_behavior/neurological_phenoty1.35273139
39MP0002638_abnormal_pupillary_reflex1.29033033
40MP0004782_abnormal_surfactant_physiolog1.27800862
41MP0001905_abnormal_dopamine_level1.25905466
42MP0000427_abnormal_hair_cycle1.25341624
43MP0000538_abnormal_urinary_bladder1.24560711
44MP0005395_other_phenotype1.20026567
45MP0005075_abnormal_melanosome_morpholog1.17925113
46MP0001486_abnormal_startle_reflex1.16796440
47MP0002168_other_aberrant_phenotype1.14684253
48MP0005410_abnormal_fertilization1.14360134
49MP0008872_abnormal_physiological_respon1.10478733
50MP0005085_abnormal_gallbladder_physiolo1.10223336
51MP0002064_seizures1.07957073
52MP0004043_abnormal_pH_regulation1.07189334
53MP0003880_abnormal_central_pattern1.06674717
54MP0002067_abnormal_sensory_capabilities1.06253629
55MP0004145_abnormal_muscle_electrophysio1.05068144
56MP0001501_abnormal_sleep_pattern1.04420624
57MP0009278_abnormal_bone_marrow1.03606014
58MP0003631_nervous_system_phenotype1.00169795
59MP0002572_abnormal_emotion/affect_behav0.99515554
60MP0010368_abnormal_lymphatic_system0.97990297
61MP0002734_abnormal_mechanical_nocicepti0.97913366
62MP0003172_abnormal_lysosome_physiology0.97842973
63MP0005253_abnormal_eye_physiology0.97553540
64MP0001970_abnormal_pain_threshold0.94865755
65MP0003635_abnormal_synaptic_transmissio0.94803440
66MP0002229_neurodegeneration0.94694757
67MP0005464_abnormal_platelet_physiology0.94109514
68MP0001485_abnormal_pinna_reflex0.92935514
69MP0003632_abnormal_nervous_system0.92692019
70MP0003950_abnormal_plasma_membrane0.92334678
71MP0001986_abnormal_taste_sensitivity0.91767265
72MP0002277_abnormal_respiratory_mucosa0.90922178
73MP0005645_abnormal_hypothalamus_physiol0.90552655
74MP0003633_abnormal_nervous_system0.90245722
75MP0003186_abnormal_redox_activity0.87686497
76MP0002177_abnormal_outer_ear0.84961986
77MP0003937_abnormal_limbs/digits/tail_de0.83923922
78MP0010678_abnormal_skin_adnexa0.83729677
79MP0004215_abnormal_myocardial_fiber0.83225079
80MP0004484_altered_response_of0.79491832
81MP0005397_hematopoietic_system_phenotyp0.79422092
82MP0001545_abnormal_hematopoietic_system0.79422092
83MP0004133_heterotaxia0.78411051
84MP0002063_abnormal_learning/memory/cond0.76320037
85MP0002733_abnormal_thermal_nociception0.75717867
86MP0001666_abnormal_nutrient_absorption0.75282549
87MP0002160_abnormal_reproductive_system0.73964916
88MP0002693_abnormal_pancreas_physiology0.72867734
89MP0002933_joint_inflammation0.72030773
90MP0004270_analgesia0.71997886
91MP0004883_abnormal_blood_vessel0.71011350
92MP0002557_abnormal_social/conspecific_i0.70180285
93MP0008770_decreased_survivor_rate0.70175617
94MP0006072_abnormal_retinal_apoptosis0.67630990
95MP0001177_atelectasis0.64868406
96MP0005365_abnormal_bile_salt0.63020085
97MP0006276_abnormal_autonomic_nervous0.62016367
98MP0000003_abnormal_adipose_tissue0.60050346
99MP0001929_abnormal_gametogenesis0.59918782
100MP0008775_abnormal_heart_ventricle0.59763079

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)4.95797563
2Abnormal biliary tract physiology (HP:0012439)4.73585755
3Bile duct proliferation (HP:0001408)4.73585755
4Abnormality of macular pigmentation (HP:0008002)4.69786009
5Pancreatic fibrosis (HP:0100732)4.69218949
6True hermaphroditism (HP:0010459)4.68362462
7Abnormality of midbrain morphology (HP:0002418)4.68340366
8Molar tooth sign on MRI (HP:0002419)4.68340366
9Pancreatic cysts (HP:0001737)4.28313211
10Optic nerve coloboma (HP:0000588)3.96503955
11Cupped ear (HP:0000378)3.78994139
12Chronic hepatic failure (HP:0100626)3.55245735
13Rectal prolapse (HP:0002035)3.50702603
14Facial hemangioma (HP:0000329)3.45358786
15Cystic liver disease (HP:0006706)3.42160530
16Sclerocornea (HP:0000647)3.38864641
17Scanning speech (HP:0002168)3.30887006
18Nephronophthisis (HP:0000090)3.17412665
19Furrowed tongue (HP:0000221)3.09586094
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05551251
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.92936396
22Aplasia/Hypoplasia of the tongue (HP:0010295)2.83469339
23Choroideremia (HP:0001139)2.75421002
24Conjunctival telangiectasia (HP:0000524)2.74071560
25Male pseudohermaphroditism (HP:0000037)2.70758226
26Abnormal rod and cone electroretinograms (HP:0008323)2.64978732
27Upper motor neuron abnormality (HP:0002127)2.63098662
28Abnormality of the axillary hair (HP:0100134)2.59620431
29Abnormality of secondary sexual hair (HP:0009888)2.59620431
30Abnormality of abdominal situs (HP:0011620)2.58962765
31Abdominal situs inversus (HP:0003363)2.58962765
32Abolished electroretinogram (ERG) (HP:0000550)2.57408435
33Large for gestational age (HP:0001520)2.55015236
34Pheochromocytoma (HP:0002666)2.54877621
35Esophageal neoplasm (HP:0100751)2.53911420
36Neoplasm of head and neck (HP:0012288)2.53911420
37Preaxial hand polydactyly (HP:0001177)2.53368633
38Cerebral hemorrhage (HP:0001342)2.51010517
39Supernumerary nipples (HP:0002558)2.48780038
40Sex reversal (HP:0012245)2.48512407
41Abnormal sex determination (HP:0012244)2.48512407
42Anencephaly (HP:0002323)2.45749628
43Gait imbalance (HP:0002141)2.44679039
44Intrahepatic cholestasis (HP:0001406)2.41502015
45Pendular nystagmus (HP:0012043)2.39973481
46Tachypnea (HP:0002789)2.39299060
47Abnormality of the renal medulla (HP:0100957)2.37704253
48Distal lower limb muscle weakness (HP:0009053)2.35720143
49Decreased central vision (HP:0007663)2.33137453
50Medial flaring of the eyebrow (HP:0010747)2.32754593
51Bifid tongue (HP:0010297)2.30980734
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29622635
53Congenital hepatic fibrosis (HP:0002612)2.29114421
54Morphological abnormality of the pyramidal tract (HP:0002062)2.28577988
55Colon cancer (HP:0003003)2.27779682
56Postaxial hand polydactyly (HP:0001162)2.26470237
57Congenital stationary night blindness (HP:0007642)2.25372755
58Hyperglycinuria (HP:0003108)2.25068426
59Hydroureter (HP:0000072)2.22070377
60Retinal dysplasia (HP:0007973)2.21546704
61Ulnar claw (HP:0001178)2.21265663
62Vascular calcification (HP:0004934)2.19746255
63Megalencephaly (HP:0001355)2.18581797
64Congenital primary aphakia (HP:0007707)2.17555804
65Neuroendocrine neoplasm (HP:0100634)2.11973291
66Postaxial foot polydactyly (HP:0001830)2.10849620
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07169888
68Occipital encephalocele (HP:0002085)2.04039076
69Type 2 muscle fiber atrophy (HP:0003554)2.02784413
70Posterior subcapsular cataract (HP:0007787)1.99379401
71Neoplasm of the adrenal gland (HP:0100631)1.99359185
72Gonadal dysgenesis (HP:0000133)1.97241374
73Attenuation of retinal blood vessels (HP:0007843)1.96429548
74Impaired smooth pursuit (HP:0007772)1.95107099
75Confusion (HP:0001289)1.94917784
76Conjunctival hamartoma (HP:0100780)1.94704582
77Abnormality of the gallbladder (HP:0005264)1.93800258
78Keratoconus (HP:0000563)1.93475733
79Increased corneal curvature (HP:0100692)1.93475733
80Hyperventilation (HP:0002883)1.91576485
81Hypokinesia (HP:0002375)1.90293774
82Nephrogenic diabetes insipidus (HP:0009806)1.89172864
83Palpitations (HP:0001962)1.87449497
84Tubular atrophy (HP:0000092)1.85760411
85Abnormal gallbladder morphology (HP:0012437)1.85759531
86Concave nail (HP:0001598)1.84090795
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83409603
88Cardiovascular calcification (HP:0011915)1.80746662
89Chronic mucocutaneous candidiasis (HP:0002728)1.79390744
90Recurrent cutaneous fungal infections (HP:0011370)1.79390744
91Hemiparesis (HP:0001269)1.76979418
92Anophthalmia (HP:0000528)1.76756779
93Spastic tetraparesis (HP:0001285)1.76344098
94Pulmonary artery stenosis (HP:0004415)1.75886677
95Hyperammonemia (HP:0001987)1.72130237
96Amyloidosis (HP:0011034)1.71373105
97Type I transferrin isoform profile (HP:0003642)1.70067380
98Type II lissencephaly (HP:0007260)1.69189737
99Narrow forehead (HP:0000341)1.69169973
100Hamartoma of the eye (HP:0010568)1.68357695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF6.60053263
2PIM24.60139285
3TAF12.89760770
4EIF2AK12.88039754
5TIE12.84583265
6EIF2AK32.81555809
7FRK2.61231284
8VRK22.55258451
9BRAF2.42538670
10WNK42.25964584
11TEC2.14182819
12MAP4K22.13800873
13MAP2K62.00477314
14PTK2B1.98283109
15MAP3K11.96500653
16MAPK131.83528537
17ADRBK21.79927310
18NTRK31.78033471
19MAPKAPK51.76080926
20RAF11.73329191
21NEK11.62695937
22DAPK21.62278126
23PLK21.57665737
24EIF2AK21.44546270
25GRK51.42424361
26ACVR1B1.39854685
27BCKDK1.37311847
28MAPK121.28676382
29STK391.28379366
30WNK31.22794849
31NUAK11.19095021
32PRKCI1.18001129
33INSRR1.12905760
34BMPR1B1.12277720
35WNK11.10236135
36MARK11.08824757
37TNIK1.04178031
38SIK31.02766421
39PRKCE0.97083404
40TRIM280.96685139
41PKN10.94522517
42CSNK1G20.93236227
43BCR0.89074982
44ITK0.88337439
45PIK3CA0.87926347
46STK38L0.87431387
47OXSR10.86986349
48CSNK1G30.84579319
49ADRBK10.83476085
50PRKG20.82544797
51KDR0.81909802
52PAK10.79784805
53CSNK1A1L0.76909379
54PHKG10.75808448
55PHKG20.75808448
56SMG10.75015669
57VRK10.74077189
58DYRK20.73719792
59MAP3K40.72279524
60BTK0.65601190
61DYRK1A0.63347710
62CSNK1G10.61686743
63RPS6KA50.57542342
64PIK3CG0.57236947
65RPS6KA20.56102705
66AKT20.54934616
67MAP2K40.54481670
68ABL20.53233614
69PAK30.51739726
70CAMK2G0.49673842
71CAMK2A0.48703089
72GRK10.48574817
73ERBB20.48392997
74PRKAA20.45003451
75CAMK2B0.43262953
76CAMK2D0.42682743
77RPS6KA60.40764245
78WEE10.39352271
79CDK90.39268544
80MINK10.38562720
81PDK10.37625007
82CDK50.36915931
83MAP2K70.34542879
84FER0.33450378
85CAMKK20.32515680
86CASK0.32412163
87PRKCQ0.31753090
88RPS6KL10.30527408
89RPS6KC10.30527408
90PRKAA10.30223870
91SYK0.30044947
92CHEK20.29155799
93PRKCZ0.28726666
94TAOK30.28389387
95BRSK20.27346385
96STK380.27246188
97NME10.26044256
98TGFBR10.25874162
99PRKCG0.25856031
100MAPK80.24518325

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.69355215
2Butanoate metabolism_Homo sapiens_hsa006503.79789323
3Regulation of autophagy_Homo sapiens_hsa041403.44139300
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.76179566
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.61019539
6Fatty acid elongation_Homo sapiens_hsa000622.52535308
7ABC transporters_Homo sapiens_hsa020102.41886826
8Linoleic acid metabolism_Homo sapiens_hsa005912.40492831
9Fatty acid metabolism_Homo sapiens_hsa012122.14363973
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11343178
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.08964530
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01402346
13Homologous recombination_Homo sapiens_hsa034401.94515958
14Caffeine metabolism_Homo sapiens_hsa002321.88294315
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86378210
16Sulfur relay system_Homo sapiens_hsa041221.75855217
17Fatty acid degradation_Homo sapiens_hsa000711.63038738
18Glutamatergic synapse_Homo sapiens_hsa047241.54578072
19Tryptophan metabolism_Homo sapiens_hsa003801.50024462
20Basal transcription factors_Homo sapiens_hsa030221.44031771
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43590237
22African trypanosomiasis_Homo sapiens_hsa051431.42089105
23Nitrogen metabolism_Homo sapiens_hsa009101.41591296
24Arginine biosynthesis_Homo sapiens_hsa002201.39985559
25Taste transduction_Homo sapiens_hsa047421.39383345
26Fructose and mannose metabolism_Homo sapiens_hsa000511.38025572
27Propanoate metabolism_Homo sapiens_hsa006401.27542547
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25832853
29Ether lipid metabolism_Homo sapiens_hsa005651.25735095
30Base excision repair_Homo sapiens_hsa034101.23025671
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.21134330
32Long-term depression_Homo sapiens_hsa047301.18767268
33Calcium signaling pathway_Homo sapiens_hsa040201.17853904
34Arginine and proline metabolism_Homo sapiens_hsa003301.17785817
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17459104
36Insulin secretion_Homo sapiens_hsa049111.15424219
37Chemical carcinogenesis_Homo sapiens_hsa052041.12001324
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10056165
39Pancreatic secretion_Homo sapiens_hsa049721.08567049
40Arachidonic acid metabolism_Homo sapiens_hsa005901.07820027
41Sulfur metabolism_Homo sapiens_hsa009201.05105635
42Salivary secretion_Homo sapiens_hsa049701.01342986
43VEGF signaling pathway_Homo sapiens_hsa043700.99934367
44Fat digestion and absorption_Homo sapiens_hsa049750.96627135
45Steroid biosynthesis_Homo sapiens_hsa001000.94835682
46Phototransduction_Homo sapiens_hsa047440.94589117
47Nicotine addiction_Homo sapiens_hsa050330.92186240
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91721381
49Histidine metabolism_Homo sapiens_hsa003400.91710124
50GnRH signaling pathway_Homo sapiens_hsa049120.90490437
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89842620
52Vitamin digestion and absorption_Homo sapiens_hsa049770.87935713
53Circadian entrainment_Homo sapiens_hsa047130.87056092
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84582747
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78075777
56Dopaminergic synapse_Homo sapiens_hsa047280.72735518
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70355415
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.70053723
59Lysine degradation_Homo sapiens_hsa003100.66297399
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.66181124
61Retinol metabolism_Homo sapiens_hsa008300.65590570
62Peroxisome_Homo sapiens_hsa041460.64797039
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64002326
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63790397
65Mismatch repair_Homo sapiens_hsa034300.63051599
66Starch and sucrose metabolism_Homo sapiens_hsa005000.62936378
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61648394
68RNA polymerase_Homo sapiens_hsa030200.59354893
69Olfactory transduction_Homo sapiens_hsa047400.59294807
70Serotonergic synapse_Homo sapiens_hsa047260.58110727
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57920107
72Amphetamine addiction_Homo sapiens_hsa050310.57356346
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56374588
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54874139
75Metabolic pathways_Homo sapiens_hsa011000.52490973
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52197693
77beta-Alanine metabolism_Homo sapiens_hsa004100.51886270
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51606346
79Renin secretion_Homo sapiens_hsa049240.51566625
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50195307
81One carbon pool by folate_Homo sapiens_hsa006700.49759156
82Tyrosine metabolism_Homo sapiens_hsa003500.48987348
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47213950
84Fanconi anemia pathway_Homo sapiens_hsa034600.46831730
85Gastric acid secretion_Homo sapiens_hsa049710.46337101
86Huntingtons disease_Homo sapiens_hsa050160.45998414
87Renin-angiotensin system_Homo sapiens_hsa046140.44029314
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.43806113
89Platelet activation_Homo sapiens_hsa046110.43785993
90Pyrimidine metabolism_Homo sapiens_hsa002400.43567329
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43360301
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41406658
93Morphine addiction_Homo sapiens_hsa050320.41081075
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41013033
95Ovarian steroidogenesis_Homo sapiens_hsa049130.39780248
96p53 signaling pathway_Homo sapiens_hsa041150.39704885
97PPAR signaling pathway_Homo sapiens_hsa033200.37827001
98Inositol phosphate metabolism_Homo sapiens_hsa005620.37673214
99Asthma_Homo sapiens_hsa053100.36814880
100Alzheimers disease_Homo sapiens_hsa050100.36604124

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