KRT8P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)9.55723311
2positive regulation of growth hormone secretion (GO:0060124)7.80451791
3positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-5.46205075
4regulation of growth hormone secretion (GO:0060123)4.76252885
5daunorubicin metabolic process (GO:0044597)4.36637814
6polyketide metabolic process (GO:0030638)4.36637814
7doxorubicin metabolic process (GO:0044598)4.36637814
8GTP biosynthetic process (GO:0006183)4.33891919
9proteasome assembly (GO:0043248)4.25205222
10protein maturation by protein folding (GO:0022417)4.13177114
11UTP biosynthetic process (GO:0006228)4.09426347
12ribosome assembly (GO:0042255)4.09288383
13fat-soluble vitamin biosynthetic process (GO:0042362)4.05554236
14aminoglycoside antibiotic metabolic process (GO:0030647)4.02957410
15mitochondrial calcium ion transport (GO:0006851)4.01224468
16artery smooth muscle contraction (GO:0014824)3.95931511
17pyrimidine-containing compound transmembrane transport (GO:0072531)3.87746594
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.85428534
19vitamin transmembrane transport (GO:0035461)3.84122255
20regulation of cellular amino acid metabolic process (GO:0006521)3.78678958
21UTP metabolic process (GO:0046051)3.78474085
22DNA replication-dependent nucleosome organization (GO:0034723)3.74345647
23DNA replication-dependent nucleosome assembly (GO:0006335)3.74345647
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.69637910
25guanosine-containing compound biosynthetic process (GO:1901070)3.64872163
26ubiquinone biosynthetic process (GO:0006744)3.64666964
27deoxyribose phosphate biosynthetic process (GO:0046385)3.63061676
282-deoxyribonucleotide biosynthetic process (GO:0009265)3.63061676
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57408990
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57408990
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57189988
32hair cycle (GO:0042633)3.55968802
33molting cycle (GO:0042303)3.55968802
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53130039
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53130039
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53130039
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49509831
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47916856
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.47916856
40tonic smooth muscle contraction (GO:0014820)3.47271800
41cellular ketone body metabolic process (GO:0046950)3.46891786
42CTP metabolic process (GO:0046036)3.44384430
43CTP biosynthetic process (GO:0006241)3.44384430
44cobalamin metabolic process (GO:0009235)3.43718726
45quinone biosynthetic process (GO:1901663)3.43062410
46L-serine transport (GO:0015825)3.40089771
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.39790713
48pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.39623522
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34445623
50pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.31687488
51antibacterial humoral response (GO:0019731)3.31223748
52vitamin biosynthetic process (GO:0009110)3.22658765
53pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21345170
54deoxyribonucleotide biosynthetic process (GO:0009263)3.19558968
55serine transport (GO:0032329)3.18677608
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16622839
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14975626
58pentose metabolic process (GO:0019321)3.13508548
59pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.12972077
60alanine transport (GO:0032328)3.11618319
61ubiquinone metabolic process (GO:0006743)3.11066170
62cullin deneddylation (GO:0010388)3.10189571
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07240505
64quinone metabolic process (GO:1901661)3.06082315
65nucleoside salvage (GO:0043174)3.05782858
66positive regulation of ligase activity (GO:0051351)3.05180657
67GDP-mannose metabolic process (GO:0019673)3.02862922
68ketone body metabolic process (GO:1902224)3.00951526
69antimicrobial humoral response (GO:0019730)2.99387506
70ATP synthesis coupled proton transport (GO:0015986)2.94076568
71energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94076568
72protein deneddylation (GO:0000338)2.93327307
73retina homeostasis (GO:0001895)2.90941857
74photoreceptor cell differentiation (GO:0046530)2.89116635
75eye photoreceptor cell differentiation (GO:0001754)2.89116635
76positive regulation of cell cycle arrest (GO:0071158)2.85116941
77Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84967261
78C4-dicarboxylate transport (GO:0015740)2.84865794
79calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.79895286
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78293448
81mitochondrial RNA metabolic process (GO:0000959)2.77954389
82spliceosomal snRNP assembly (GO:0000387)2.77847929
83purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77048196
84ribosomal large subunit biogenesis (GO:0042273)2.76975080
85DNA replication checkpoint (GO:0000076)2.76489709
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75751943
87negative regulation of ligase activity (GO:0051352)2.75751943
88NADH metabolic process (GO:0006734)2.74878081
89desmosome organization (GO:0002934)2.74681102
90regulation of cellular amine metabolic process (GO:0033238)2.74588819
91peptidyl-arginine omega-N-methylation (GO:0035247)2.70635498
92dicarboxylic acid catabolic process (GO:0043649)2.66813835
93pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.64125593
94GMP metabolic process (GO:0046037)2.63064173
95nucleobase biosynthetic process (GO:0046112)2.61538245
96DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.60946564
97digestion (GO:0007586)2.60608006
98L-fucose catabolic process (GO:0042355)2.59784369
99fucose catabolic process (GO:0019317)2.59784369
100L-fucose metabolic process (GO:0042354)2.59784369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.70016007
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68348070
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21631493
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.14560319
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93062554
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.74621396
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59205253
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54992539
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52742084
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45552708
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45205776
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41880966
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.28380579
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27683935
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.23548451
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06583409
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat10.5352062
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97511352
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.90837730
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84282467
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84026836
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.83338262
23PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.82894161
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82051562
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75987875
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68763836
27DCP1A_22483619_ChIP-Seq_HELA_Human1.67476776
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.67292350
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65410186
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62878354
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62785851
32VDR_23849224_ChIP-Seq_CD4+_Human1.59054837
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.54052315
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53109940
35VDR_22108803_ChIP-Seq_LS180_Human1.48341672
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37283537
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36830809
38BCOR_27268052_Chip-Seq_Bcells_Human1.31894122
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28798470
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.27041399
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26372389
42GABP_19822575_ChIP-Seq_HepG2_Human1.22651683
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21560612
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19394882
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18620970
46FOXP3_21729870_ChIP-Seq_TREG_Human1.18329349
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.17103991
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14873215
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14524412
50GATA4_25053715_ChIP-Seq_YYC3_Human1.12810397
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12417666
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12252324
53KDM5A_27292631_Chip-Seq_BREAST_Human1.10360119
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09324894
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07582258
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.07236021
57XRN2_22483619_ChIP-Seq_HELA_Human1.07057480
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06948648
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06791833
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06197515
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05919482
62AR_20517297_ChIP-Seq_VCAP_Human1.05726256
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05671591
64E2F1_20622854_ChIP-Seq_HELA_Human1.05464131
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05204532
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.05032655
67PHF8_20622854_ChIP-Seq_HELA_Human1.01455047
68E2F7_22180533_ChIP-Seq_HELA_Human1.00175612
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00168557
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99575128
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98930827
72GATA6_25053715_ChIP-Seq_YYC3_Human0.98501671
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98184437
74P300_27268052_Chip-Seq_Bcells_Human0.96533472
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96477811
76IRF1_19129219_ChIP-ChIP_H3396_Human0.95993782
77SOX2_21211035_ChIP-Seq_LN229_Human0.95503051
78CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95457415
79IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94791790
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94311234
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93938210
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93329137
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92702064
84BCL6_27268052_Chip-Seq_Bcells_Human0.92144452
85CSB_26484114_Chip-Seq_FIBROBLAST_Human0.91318936
86ELK1_19687146_ChIP-ChIP_HELA_Human0.90732436
87NANOG_20526341_ChIP-Seq_ESCs_Human0.89689828
88TTF2_22483619_ChIP-Seq_HELA_Human0.87689072
89STAT1_20625510_ChIP-Seq_HELA_Human0.86954705
90PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86214257
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85531599
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85189045
93CTCF_20526341_ChIP-Seq_ESCs_Human0.84379785
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.84201725
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.83141037
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82364914
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82342625
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.82210892
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81234655
100ATF3_27146783_Chip-Seq_COLON_Human0.80490787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005379_endocrine/exocrine_gland_phen6.37491301
2MP0003806_abnormal_nucleotide_metabolis4.02304301
3MP0000647_abnormal_sebaceous_gland3.06545440
4MP0003878_abnormal_ear_physiology3.06353493
5MP0005377_hearing/vestibular/ear_phenot3.06353493
6MP0000613_abnormal_salivary_gland2.87838682
7MP0005360_urolithiasis2.85768669
8MP0001984_abnormal_olfaction2.52977318
9MP0001348_abnormal_lacrimal_gland2.27974964
10MP0001666_abnormal_nutrient_absorption2.11229112
11MP0010234_abnormal_vibrissa_follicle2.09954839
12MP0002163_abnormal_gland_morphology10.4885687
13MP0003315_abnormal_perineum_morphology1.97743299
14MP0003693_abnormal_embryo_hatching1.95511024
15MP0008875_abnormal_xenobiotic_pharmacok1.91198563
16MP0010352_gastrointestinal_tract_polyps1.89700026
17MP0004147_increased_porphyrin_level1.83958508
18MP0003718_maternal_effect1.69190238
19MP0005645_abnormal_hypothalamus_physiol1.65232214
20MP0001764_abnormal_homeostasis1.64559372
21MP0001529_abnormal_vocalization1.61996232
22MP0002102_abnormal_ear_morphology1.57276464
23MP0003941_abnormal_skin_development1.49917054
24MP0002098_abnormal_vibrissa_morphology1.45909715
25MP0002132_abnormal_respiratory_system1.44243256
26MP0003195_calcinosis1.42252934
27MP0000639_abnormal_adrenal_gland1.41668374
28MP0005085_abnormal_gallbladder_physiolo1.40567460
29MP0002277_abnormal_respiratory_mucosa1.36209169
30MP0004264_abnormal_extraembryonic_tissu1.35520256
31MP0005410_abnormal_fertilization1.33782111
32MP0008872_abnormal_physiological_respon1.32433555
33MP0004019_abnormal_vitamin_homeostasis1.29652212
34MP0000537_abnormal_urethra_morphology1.25306862
35MP0000538_abnormal_urinary_bladder1.22841730
36MP0005332_abnormal_amino_acid1.22162946
37MP0005084_abnormal_gallbladder_morpholo1.20270399
38MP0005670_abnormal_white_adipose1.17963415
39MP0010386_abnormal_urinary_bladder1.17623263
40MP0000462_abnormal_digestive_system1.15760431
41MP0002796_impaired_skin_barrier1.14899496
42MP0005365_abnormal_bile_salt1.12635411
43MP0001664_abnormal_digestion1.09665753
44MP0008260_abnormal_autophagy1.07910439
45MP0004381_abnormal_hair_follicle1.07265553
46MP0008058_abnormal_DNA_repair1.04915410
47MP0010094_abnormal_chromosome_stability1.02594470
48MP0003136_yellow_coat_color1.02212656
49MP0006036_abnormal_mitochondrial_physio1.01910010
50MP0002139_abnormal_hepatobiliary_system0.99742461
51MP0001243_abnormal_dermal_layer0.99297703
52MP0003300_gastrointestinal_ulcer0.98111541
53MP0002653_abnormal_ependyma_morphology0.98064521
54MP0000013_abnormal_adipose_tissue0.95488706
55MP0003646_muscle_fatigue0.93788794
56MP0005501_abnormal_skin_physiology0.93785153
57MP0003950_abnormal_plasma_membrane0.91771640
58MP0000372_irregular_coat_pigmentation0.90669234
59MP0009840_abnormal_foam_cell0.89201760
60MP0004957_abnormal_blastocyst_morpholog0.85078267
61MP0010329_abnormal_lipoprotein_level0.83259261
62MP0009643_abnormal_urine_homeostasis0.81954656
63MP0002138_abnormal_hepatobiliary_system0.80353595
64MP0010155_abnormal_intestine_physiology0.80289377
65MP0006035_abnormal_mitochondrial_morpho0.80096942
66MP0005187_abnormal_penis_morphology0.77769416
67MP0000579_abnormal_nail_morphology0.75123747
68MP0005075_abnormal_melanosome_morpholog0.74914250
69MP0003936_abnormal_reproductive_system0.73387845
70MP0001756_abnormal_urination0.69852239
71MP0000627_abnormal_mammary_gland0.69688244
72MP0005083_abnormal_biliary_tract0.68395751
73MP0005451_abnormal_body_composition0.66428279
74MP0005636_abnormal_mineral_homeostasis0.65884631
75MP0005330_cardiomyopathy0.65767938
76MP0003111_abnormal_nucleus_morphology0.65676222
77MP0003868_abnormal_feces_composition0.65145748
78MP0001216_abnormal_epidermal_layer0.64642865
79MP0005023_abnormal_wound_healing0.60913311
80MP0002693_abnormal_pancreas_physiology0.60866311
81MP0001963_abnormal_hearing_physiology0.60055384
82MP0001485_abnormal_pinna_reflex0.59591596
83MP0005319_abnormal_enzyme/_coenzyme0.55519152
84MP0010678_abnormal_skin_adnexa0.55404158
85MP0001765_abnormal_ion_homeostasis0.53947703
86MP0003786_premature_aging0.53559825
87MP0010771_integument_phenotype0.53117782
88MP0002210_abnormal_sex_determination0.52659194
89MP0005551_abnormal_eye_electrophysiolog0.51895386
90MP0000477_abnormal_intestine_morphology0.50779673
91MP0002136_abnormal_kidney_physiology0.50143566
92MP0005220_abnormal_exocrine_pancreas0.49687687
93MP0000377_abnormal_hair_follicle0.49108465
94MP0005584_abnormal_enzyme/coenzyme_acti0.48779652
95MP0003252_abnormal_bile_duct0.48772484
96MP0005266_abnormal_metabolism0.48180307
97MP0000026_abnormal_inner_ear0.47844892
98MP0005395_other_phenotype0.47516007
99MP0000367_abnormal_coat/_hair0.46892996
100MP0001730_embryonic_growth_arrest0.46322440

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)4.89179901
2Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95213371
3Hypotrichosis (HP:0001006)3.73022129
4Abnormality of sulfur amino acid metabolism (HP:0004339)3.65293172
5Abnormality of methionine metabolism (HP:0010901)3.65240572
6Steatorrhea (HP:0002570)3.61695397
7Abnormality of aspartate family amino acid metabolism (HP:0010899)3.51511813
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.49967871
9Absent/shortened dynein arms (HP:0200106)3.49967871
10Hydroxyprolinuria (HP:0003080)3.39408691
11Abnormality of proline metabolism (HP:0010907)3.39408691
12Anosmia (HP:0000458)3.37270222
13Ileus (HP:0002595)3.24992768
14Pigmentary retinal degeneration (HP:0001146)3.13696885
15Type I transferrin isoform profile (HP:0003642)3.10727295
16Hypokinesia (HP:0002375)3.04804809
17Fat malabsorption (HP:0002630)2.93502437
18Mitochondrial inheritance (HP:0001427)2.81646016
19Acute necrotizing encephalopathy (HP:0006965)2.80644997
20Acute encephalopathy (HP:0006846)2.80087080
21Aplastic anemia (HP:0001915)2.79492463
22Hypoproteinemia (HP:0003075)2.69046749
23Abnormal mitochondria in muscle tissue (HP:0008316)2.65600631
24Trismus (HP:0000211)2.65074366
25Entropion (HP:0000621)2.61796268
26Amelogenesis imperfecta (HP:0000705)2.61334570
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58054619
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58054619
29Rectal prolapse (HP:0002035)2.56958924
30Reduced antithrombin III activity (HP:0001976)2.56384503
31Sparse eyelashes (HP:0000653)2.55217818
32Abnormal hair laboratory examination (HP:0003328)2.51523198
33Tongue fasciculations (HP:0001308)2.50502238
34Hyperammonemia (HP:0001987)2.50262530
35Intrahepatic cholestasis (HP:0001406)2.48914723
36Unilateral renal agenesis (HP:0000122)2.48249111
37Male infertility (HP:0003251)2.47404665
38Confusion (HP:0001289)2.41672663
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37095082
40Abnormal protein N-linked glycosylation (HP:0012347)2.37095082
41Abnormal protein glycosylation (HP:0012346)2.37095082
42Abnormal glycosylation (HP:0012345)2.37095082
43Abnormality of purine metabolism (HP:0004352)2.35323329
44Lethargy (HP:0001254)2.34101009
45Increased CSF lactate (HP:0002490)2.33722323
46Paraparesis (HP:0002385)2.30585083
47Muscle fibrillation (HP:0010546)2.30258433
48Lactic acidosis (HP:0003128)2.28160483
49Cerebral edema (HP:0002181)2.24336727
50Decreased subcutaneous fat (HP:0001002)2.24118836
51Lipid accumulation in hepatocytes (HP:0006561)2.22315183
52Hepatocellular necrosis (HP:0001404)2.21786506
53Erythema (HP:0010783)2.21598023
54Vascular calcification (HP:0004934)2.21154042
55Abnormal number of erythroid precursors (HP:0012131)2.19302582
56Nail dystrophy (HP:0008404)2.19071328
57Abnormality of nucleobase metabolism (HP:0010932)2.16062778
58Aqueductal stenosis (HP:0002410)2.14849448
59Abnormality of homocysteine metabolism (HP:0010919)2.14214107
60Homocystinuria (HP:0002156)2.14214107
61Abnormality of vitamin metabolism (HP:0100508)2.10064127
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10049905
633-Methylglutaconic aciduria (HP:0003535)2.08782308
64Opisthotonus (HP:0002179)2.08719890
65Congenital ichthyosiform erythroderma (HP:0007431)2.08661227
66Vacuolated lymphocytes (HP:0001922)2.08591313
67Hepatic necrosis (HP:0002605)2.07535871
68Chronic otitis media (HP:0000389)2.05958648
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05393539
70Abnormality of the right ventricle (HP:0001707)2.03239625
71True hermaphroditism (HP:0010459)2.03018005
72Progressive macrocephaly (HP:0004481)2.02967794
73Abnormality of vitamin B metabolism (HP:0004340)2.01013016
74Abnormality of the distal phalanges of the toes (HP:0010182)1.99657990
75Absent thumb (HP:0009777)1.98171168
76Abnormality of serum amino acid levels (HP:0003112)1.97998077
77Septate vagina (HP:0001153)1.97617726
78Dry hair (HP:0011359)1.97400141
79Dicarboxylic aciduria (HP:0003215)1.96833991
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96833991
81Tetraparesis (HP:0002273)1.96291215
82Cerebral palsy (HP:0100021)1.95872532
83Spastic paraparesis (HP:0002313)1.95768138
84Aplasia cutis congenita (HP:0001057)1.95146077
85Abnormal spermatogenesis (HP:0008669)1.94960635
86Palpitations (HP:0001962)1.94473717
87Hypogonadotrophic hypogonadism (HP:0000044)1.94405406
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.94311334
89Mutism (HP:0002300)1.91676452
90Large for gestational age (HP:0001520)1.89487811
91Increased serum lactate (HP:0002151)1.88581315
92Partial agenesis of the corpus callosum (HP:0001338)1.87625984
93Upper limb amyotrophy (HP:0009129)1.86727922
94Distal upper limb amyotrophy (HP:0007149)1.86727922
95Concave nail (HP:0001598)1.85156491
96Increased hepatocellular lipid droplets (HP:0006565)1.84944223
97Exocrine pancreatic insufficiency (HP:0001738)1.81940288
98Rough bone trabeculation (HP:0100670)1.81778206
99Progressive sensorineural hearing impairment (HP:0000408)1.81438222
100Nausea (HP:0002018)1.78519838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.57176437
2ZAK5.46877890
3LMTK25.07529323
4EPHA24.70997456
5BUB13.95976871
6NEK13.54177095
7MAP3K123.08666082
8TXK3.07518115
9SCYL22.71961205
10VRK12.45774366
11PBK2.19734204
12STK162.17030989
13MST1R2.15569308
14SMG12.15208039
15VRK21.94642388
16TESK11.68720304
17ADRBK21.59079060
18MST41.57037391
19MAP3K31.55082496
20PASK1.46778141
21MYLK1.44319705
22LIMK11.42453384
23TAF11.23004744
24TESK21.17586888
25NLK1.15788589
26AURKA1.15363170
27PDK21.05215791
28KDR1.05022613
29RPS6KB21.01595954
30FER1.01106847
31BLK0.99415156
32DAPK30.98349101
33PRKG20.96276617
34EIF2AK30.95922556
35MAP3K110.94254375
36MAPKAPK30.86511722
37MET0.85721216
38NUAK10.85604554
39PAK40.80651152
40GRK10.78481137
41RPS6KA50.74979159
42BCKDK0.73562086
43EPHA30.70674244
44STK390.70413762
45ROCK10.68824815
46DAPK10.66342548
47STK100.65283563
48CDK90.61152152
49RPS6KA40.58326520
50GRK70.55239079
51WNK40.54408155
52PIM20.53616387
53RIPK40.53224488
54ARAF0.51881101
55CCNB10.50769186
56ABL20.50720122
57AKT20.50384994
58TSSK60.48209544
59AURKB0.47257660
60PAK10.45553264
61EPHB10.45185976
62EPHA40.40516840
63NME20.38363801
64OXSR10.37473811
65PTK60.37167944
66MAP3K10.36818775
67TNIK0.35990344
68ITK0.35511821
69PLK10.35247791
70STK40.35189518
71PTK2B0.34988177
72PTK20.34762642
73MAP2K70.34341554
74PRKCI0.32874985
75EIF2AK10.31492414
76PRKCQ0.30900239
77MAP3K80.30388614
78DYRK20.29674020
79PKN10.27990723
80ADRBK10.27854496
81MAPKAPK50.27628391
82CDC70.27181570
83IKBKE0.27139946
84CHEK20.26607792
85MAP2K30.25371210
86CAMK2G0.24341078
87BRSK10.21327624
88CSNK1G30.21104548
89TBK10.20321354
90EIF2AK20.18774411
91CDK190.18093924
92PHKG20.17772553
93PHKG10.17772553
94ILK0.17034952
95WEE10.16581928
96GRK50.16192993
97PRKCA0.15415099
98CAMK2D0.14897816
99CDK80.14661090
100MAP2K10.14286285

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.61837398
2Systemic lupus erythematosus_Homo sapiens_hsa053223.37227725
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.65491447
4Fatty acid elongation_Homo sapiens_hsa000622.39869733
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36463425
6Fat digestion and absorption_Homo sapiens_hsa049752.28963675
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19981480
8Vitamin digestion and absorption_Homo sapiens_hsa049772.17530141
9Sulfur metabolism_Homo sapiens_hsa009202.08200999
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03397008
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97751821
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96278398
13Arginine biosynthesis_Homo sapiens_hsa002201.85444889
14One carbon pool by folate_Homo sapiens_hsa006701.81385965
15Alcoholism_Homo sapiens_hsa050341.80973666
16Vibrio cholerae infection_Homo sapiens_hsa051101.80008814
17Biosynthesis of amino acids_Homo sapiens_hsa012301.75221929
18Fructose and mannose metabolism_Homo sapiens_hsa000511.73977959
19Oxidative phosphorylation_Homo sapiens_hsa001901.69525560
20Glutathione metabolism_Homo sapiens_hsa004801.63916395
21Pentose phosphate pathway_Homo sapiens_hsa000301.61522484
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55071276
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.52952287
24Selenocompound metabolism_Homo sapiens_hsa004501.40508058
25Carbon metabolism_Homo sapiens_hsa012001.36494689
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34632671
27Ribosome_Homo sapiens_hsa030101.31838760
28Chemical carcinogenesis_Homo sapiens_hsa052041.29733466
29Parkinsons disease_Homo sapiens_hsa050121.29703806
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29180117
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27976728
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24974111
33Pancreatic secretion_Homo sapiens_hsa049721.21478571
34Pyrimidine metabolism_Homo sapiens_hsa002401.19915135
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19085135
36RNA polymerase_Homo sapiens_hsa030201.18508458
37Galactose metabolism_Homo sapiens_hsa000521.15999838
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15969437
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15112022
40Nitrogen metabolism_Homo sapiens_hsa009101.14240601
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.13670573
42Sulfur relay system_Homo sapiens_hsa041221.13408383
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.11330320
44Butanoate metabolism_Homo sapiens_hsa006501.10458035
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04565223
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03558378
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.02373093
48Starch and sucrose metabolism_Homo sapiens_hsa005000.99423603
49Arginine and proline metabolism_Homo sapiens_hsa003300.98987312
50Purine metabolism_Homo sapiens_hsa002300.98540634
51Caffeine metabolism_Homo sapiens_hsa002320.95657929
52Protein digestion and absorption_Homo sapiens_hsa049740.93030442
53Glycerolipid metabolism_Homo sapiens_hsa005610.93017273
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91356836
55Renin-angiotensin system_Homo sapiens_hsa046140.89981010
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88763160
57DNA replication_Homo sapiens_hsa030300.88344942
58Spliceosome_Homo sapiens_hsa030400.87055654
59Pyruvate metabolism_Homo sapiens_hsa006200.86964978
60Huntingtons disease_Homo sapiens_hsa050160.85902341
61Nucleotide excision repair_Homo sapiens_hsa034200.85349089
62Mismatch repair_Homo sapiens_hsa034300.82025611
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80497344
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80368926
65Viral carcinogenesis_Homo sapiens_hsa052030.78567409
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77097631
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76745675
68Fatty acid metabolism_Homo sapiens_hsa012120.76729726
69Alzheimers disease_Homo sapiens_hsa050100.76352713
70Metabolic pathways_Homo sapiens_hsa011000.75585947
71Fatty acid biosynthesis_Homo sapiens_hsa000610.75556390
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.74839785
73Arachidonic acid metabolism_Homo sapiens_hsa005900.72400807
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71889966
75Tight junction_Homo sapiens_hsa045300.71570258
76Phototransduction_Homo sapiens_hsa047440.66486456
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64287884
78Phenylalanine metabolism_Homo sapiens_hsa003600.63995462
79Peroxisome_Homo sapiens_hsa041460.62600028
80Basal transcription factors_Homo sapiens_hsa030220.57071411
81ABC transporters_Homo sapiens_hsa020100.56985452
82Retinol metabolism_Homo sapiens_hsa008300.55427440
83Tyrosine metabolism_Homo sapiens_hsa003500.52186059
84Tryptophan metabolism_Homo sapiens_hsa003800.49003975
85Bile secretion_Homo sapiens_hsa049760.48680489
86Base excision repair_Homo sapiens_hsa034100.48223548
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47811729
88Mineral absorption_Homo sapiens_hsa049780.46757444
89Collecting duct acid secretion_Homo sapiens_hsa049660.46001235
90Histidine metabolism_Homo sapiens_hsa003400.45933307
91Steroid biosynthesis_Homo sapiens_hsa001000.44727400
92Other glycan degradation_Homo sapiens_hsa005110.43073622
93Folate biosynthesis_Homo sapiens_hsa007900.42726081
94Fatty acid degradation_Homo sapiens_hsa000710.42094131
95Primary immunodeficiency_Homo sapiens_hsa053400.41680259
96Homologous recombination_Homo sapiens_hsa034400.41187634
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38729935
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35082964
99RNA transport_Homo sapiens_hsa030130.34789334
100RNA degradation_Homo sapiens_hsa030180.34630975

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