

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of gonadotropin secretion (GO:0032276) | 9.55723311 |
| 2 | positive regulation of growth hormone secretion (GO:0060124) | 7.80451791 |
| 3 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G- | 5.46205075 |
| 4 | regulation of growth hormone secretion (GO:0060123) | 4.76252885 |
| 5 | daunorubicin metabolic process (GO:0044597) | 4.36637814 |
| 6 | polyketide metabolic process (GO:0030638) | 4.36637814 |
| 7 | doxorubicin metabolic process (GO:0044598) | 4.36637814 |
| 8 | GTP biosynthetic process (GO:0006183) | 4.33891919 |
| 9 | proteasome assembly (GO:0043248) | 4.25205222 |
| 10 | protein maturation by protein folding (GO:0022417) | 4.13177114 |
| 11 | UTP biosynthetic process (GO:0006228) | 4.09426347 |
| 12 | ribosome assembly (GO:0042255) | 4.09288383 |
| 13 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.05554236 |
| 14 | aminoglycoside antibiotic metabolic process (GO:0030647) | 4.02957410 |
| 15 | mitochondrial calcium ion transport (GO:0006851) | 4.01224468 |
| 16 | artery smooth muscle contraction (GO:0014824) | 3.95931511 |
| 17 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 3.87746594 |
| 18 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.85428534 |
| 19 | vitamin transmembrane transport (GO:0035461) | 3.84122255 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.78678958 |
| 21 | UTP metabolic process (GO:0046051) | 3.78474085 |
| 22 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.74345647 |
| 23 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.74345647 |
| 24 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.69637910 |
| 25 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.64872163 |
| 26 | ubiquinone biosynthetic process (GO:0006744) | 3.64666964 |
| 27 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.63061676 |
| 28 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.63061676 |
| 29 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.57408990 |
| 30 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.57408990 |
| 31 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.57189988 |
| 32 | hair cycle (GO:0042633) | 3.55968802 |
| 33 | molting cycle (GO:0042303) | 3.55968802 |
| 34 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.53130039 |
| 35 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.53130039 |
| 36 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.53130039 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.49509831 |
| 38 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.47916856 |
| 39 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.47916856 |
| 40 | tonic smooth muscle contraction (GO:0014820) | 3.47271800 |
| 41 | cellular ketone body metabolic process (GO:0046950) | 3.46891786 |
| 42 | CTP metabolic process (GO:0046036) | 3.44384430 |
| 43 | CTP biosynthetic process (GO:0006241) | 3.44384430 |
| 44 | cobalamin metabolic process (GO:0009235) | 3.43718726 |
| 45 | quinone biosynthetic process (GO:1901663) | 3.43062410 |
| 46 | L-serine transport (GO:0015825) | 3.40089771 |
| 47 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.39790713 |
| 48 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.39623522 |
| 49 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.34445623 |
| 50 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.31687488 |
| 51 | antibacterial humoral response (GO:0019731) | 3.31223748 |
| 52 | vitamin biosynthetic process (GO:0009110) | 3.22658765 |
| 53 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.21345170 |
| 54 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.19558968 |
| 55 | serine transport (GO:0032329) | 3.18677608 |
| 56 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.16622839 |
| 57 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14975626 |
| 58 | pentose metabolic process (GO:0019321) | 3.13508548 |
| 59 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.12972077 |
| 60 | alanine transport (GO:0032328) | 3.11618319 |
| 61 | ubiquinone metabolic process (GO:0006743) | 3.11066170 |
| 62 | cullin deneddylation (GO:0010388) | 3.10189571 |
| 63 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.07240505 |
| 64 | quinone metabolic process (GO:1901661) | 3.06082315 |
| 65 | nucleoside salvage (GO:0043174) | 3.05782858 |
| 66 | positive regulation of ligase activity (GO:0051351) | 3.05180657 |
| 67 | GDP-mannose metabolic process (GO:0019673) | 3.02862922 |
| 68 | ketone body metabolic process (GO:1902224) | 3.00951526 |
| 69 | antimicrobial humoral response (GO:0019730) | 2.99387506 |
| 70 | ATP synthesis coupled proton transport (GO:0015986) | 2.94076568 |
| 71 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.94076568 |
| 72 | protein deneddylation (GO:0000338) | 2.93327307 |
| 73 | retina homeostasis (GO:0001895) | 2.90941857 |
| 74 | photoreceptor cell differentiation (GO:0046530) | 2.89116635 |
| 75 | eye photoreceptor cell differentiation (GO:0001754) | 2.89116635 |
| 76 | positive regulation of cell cycle arrest (GO:0071158) | 2.85116941 |
| 77 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.84967261 |
| 78 | C4-dicarboxylate transport (GO:0015740) | 2.84865794 |
| 79 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 2.79895286 |
| 80 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.78293448 |
| 81 | mitochondrial RNA metabolic process (GO:0000959) | 2.77954389 |
| 82 | spliceosomal snRNP assembly (GO:0000387) | 2.77847929 |
| 83 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.77048196 |
| 84 | ribosomal large subunit biogenesis (GO:0042273) | 2.76975080 |
| 85 | DNA replication checkpoint (GO:0000076) | 2.76489709 |
| 86 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.75751943 |
| 87 | negative regulation of ligase activity (GO:0051352) | 2.75751943 |
| 88 | NADH metabolic process (GO:0006734) | 2.74878081 |
| 89 | desmosome organization (GO:0002934) | 2.74681102 |
| 90 | regulation of cellular amine metabolic process (GO:0033238) | 2.74588819 |
| 91 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.70635498 |
| 92 | dicarboxylic acid catabolic process (GO:0043649) | 2.66813835 |
| 93 | pyrimidine ribonucleoside biosynthetic process (GO:0046132) | 2.64125593 |
| 94 | GMP metabolic process (GO:0046037) | 2.63064173 |
| 95 | nucleobase biosynthetic process (GO:0046112) | 2.61538245 |
| 96 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.60946564 |
| 97 | digestion (GO:0007586) | 2.60608006 |
| 98 | L-fucose catabolic process (GO:0042355) | 2.59784369 |
| 99 | fucose catabolic process (GO:0019317) | 2.59784369 |
| 100 | L-fucose metabolic process (GO:0042354) | 2.59784369 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 5.70016007 |
| 2 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.68348070 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.21631493 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.14560319 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.93062554 |
| 6 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.74621396 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.59205253 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.54992539 |
| 9 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.52742084 |
| 10 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.45552708 |
| 11 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 2.45205776 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.41880966 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.28380579 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.27683935 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.23548451 |
| 16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.06583409 |
| 17 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 10.5352062 |
| 18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.97511352 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.90837730 |
| 20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.84282467 |
| 21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.84026836 |
| 22 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.83338262 |
| 23 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.82894161 |
| 24 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.82051562 |
| 25 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.75987875 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68763836 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.67476776 |
| 28 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.67292350 |
| 29 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.65410186 |
| 30 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.62878354 |
| 31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.62785851 |
| 32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.59054837 |
| 33 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.54052315 |
| 34 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.53109940 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.48341672 |
| 36 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.37283537 |
| 37 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.36830809 |
| 38 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.31894122 |
| 39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.28798470 |
| 40 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.27041399 |
| 41 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26372389 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.22651683 |
| 43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21560612 |
| 44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.19394882 |
| 45 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.18620970 |
| 46 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.18329349 |
| 47 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.17103991 |
| 48 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.14873215 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.14524412 |
| 50 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.12810397 |
| 51 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.12417666 |
| 52 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.12252324 |
| 53 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.10360119 |
| 54 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09324894 |
| 55 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.07582258 |
| 56 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.07236021 |
| 57 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.07057480 |
| 58 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.06948648 |
| 59 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.06791833 |
| 60 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.06197515 |
| 61 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.05919482 |
| 62 | AR_20517297_ChIP-Seq_VCAP_Human | 1.05726256 |
| 63 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.05671591 |
| 64 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.05464131 |
| 65 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.05204532 |
| 66 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.05032655 |
| 67 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.01455047 |
| 68 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.00175612 |
| 69 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.00168557 |
| 70 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.99575128 |
| 71 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.98930827 |
| 72 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.98501671 |
| 73 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.98184437 |
| 74 | P300_27268052_Chip-Seq_Bcells_Human | 0.96533472 |
| 75 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.96477811 |
| 76 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.95993782 |
| 77 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.95503051 |
| 78 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.95457415 |
| 79 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.94791790 |
| 80 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.94311234 |
| 81 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93938210 |
| 82 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93329137 |
| 83 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.92702064 |
| 84 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.92144452 |
| 85 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.91318936 |
| 86 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.90732436 |
| 87 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.89689828 |
| 88 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.87689072 |
| 89 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.86954705 |
| 90 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.86214257 |
| 91 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.85531599 |
| 92 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.85189045 |
| 93 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.84379785 |
| 94 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.84201725 |
| 95 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.83141037 |
| 96 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.82364914 |
| 97 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.82342625 |
| 98 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.82210892 |
| 99 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.81234655 |
| 100 | ATF3_27146783_Chip-Seq_COLON_Human | 0.80490787 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005379_endocrine/exocrine_gland_phen | 6.37491301 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 4.02304301 |
| 3 | MP0000647_abnormal_sebaceous_gland | 3.06545440 |
| 4 | MP0003878_abnormal_ear_physiology | 3.06353493 |
| 5 | MP0005377_hearing/vestibular/ear_phenot | 3.06353493 |
| 6 | MP0000613_abnormal_salivary_gland | 2.87838682 |
| 7 | MP0005360_urolithiasis | 2.85768669 |
| 8 | MP0001984_abnormal_olfaction | 2.52977318 |
| 9 | MP0001348_abnormal_lacrimal_gland | 2.27974964 |
| 10 | MP0001666_abnormal_nutrient_absorption | 2.11229112 |
| 11 | MP0010234_abnormal_vibrissa_follicle | 2.09954839 |
| 12 | MP0002163_abnormal_gland_morphology | 10.4885687 |
| 13 | MP0003315_abnormal_perineum_morphology | 1.97743299 |
| 14 | MP0003693_abnormal_embryo_hatching | 1.95511024 |
| 15 | MP0008875_abnormal_xenobiotic_pharmacok | 1.91198563 |
| 16 | MP0010352_gastrointestinal_tract_polyps | 1.89700026 |
| 17 | MP0004147_increased_porphyrin_level | 1.83958508 |
| 18 | MP0003718_maternal_effect | 1.69190238 |
| 19 | MP0005645_abnormal_hypothalamus_physiol | 1.65232214 |
| 20 | MP0001764_abnormal_homeostasis | 1.64559372 |
| 21 | MP0001529_abnormal_vocalization | 1.61996232 |
| 22 | MP0002102_abnormal_ear_morphology | 1.57276464 |
| 23 | MP0003941_abnormal_skin_development | 1.49917054 |
| 24 | MP0002098_abnormal_vibrissa_morphology | 1.45909715 |
| 25 | MP0002132_abnormal_respiratory_system | 1.44243256 |
| 26 | MP0003195_calcinosis | 1.42252934 |
| 27 | MP0000639_abnormal_adrenal_gland | 1.41668374 |
| 28 | MP0005085_abnormal_gallbladder_physiolo | 1.40567460 |
| 29 | MP0002277_abnormal_respiratory_mucosa | 1.36209169 |
| 30 | MP0004264_abnormal_extraembryonic_tissu | 1.35520256 |
| 31 | MP0005410_abnormal_fertilization | 1.33782111 |
| 32 | MP0008872_abnormal_physiological_respon | 1.32433555 |
| 33 | MP0004019_abnormal_vitamin_homeostasis | 1.29652212 |
| 34 | MP0000537_abnormal_urethra_morphology | 1.25306862 |
| 35 | MP0000538_abnormal_urinary_bladder | 1.22841730 |
| 36 | MP0005332_abnormal_amino_acid | 1.22162946 |
| 37 | MP0005084_abnormal_gallbladder_morpholo | 1.20270399 |
| 38 | MP0005670_abnormal_white_adipose | 1.17963415 |
| 39 | MP0010386_abnormal_urinary_bladder | 1.17623263 |
| 40 | MP0000462_abnormal_digestive_system | 1.15760431 |
| 41 | MP0002796_impaired_skin_barrier | 1.14899496 |
| 42 | MP0005365_abnormal_bile_salt | 1.12635411 |
| 43 | MP0001664_abnormal_digestion | 1.09665753 |
| 44 | MP0008260_abnormal_autophagy | 1.07910439 |
| 45 | MP0004381_abnormal_hair_follicle | 1.07265553 |
| 46 | MP0008058_abnormal_DNA_repair | 1.04915410 |
| 47 | MP0010094_abnormal_chromosome_stability | 1.02594470 |
| 48 | MP0003136_yellow_coat_color | 1.02212656 |
| 49 | MP0006036_abnormal_mitochondrial_physio | 1.01910010 |
| 50 | MP0002139_abnormal_hepatobiliary_system | 0.99742461 |
| 51 | MP0001243_abnormal_dermal_layer | 0.99297703 |
| 52 | MP0003300_gastrointestinal_ulcer | 0.98111541 |
| 53 | MP0002653_abnormal_ependyma_morphology | 0.98064521 |
| 54 | MP0000013_abnormal_adipose_tissue | 0.95488706 |
| 55 | MP0003646_muscle_fatigue | 0.93788794 |
| 56 | MP0005501_abnormal_skin_physiology | 0.93785153 |
| 57 | MP0003950_abnormal_plasma_membrane | 0.91771640 |
| 58 | MP0000372_irregular_coat_pigmentation | 0.90669234 |
| 59 | MP0009840_abnormal_foam_cell | 0.89201760 |
| 60 | MP0004957_abnormal_blastocyst_morpholog | 0.85078267 |
| 61 | MP0010329_abnormal_lipoprotein_level | 0.83259261 |
| 62 | MP0009643_abnormal_urine_homeostasis | 0.81954656 |
| 63 | MP0002138_abnormal_hepatobiliary_system | 0.80353595 |
| 64 | MP0010155_abnormal_intestine_physiology | 0.80289377 |
| 65 | MP0006035_abnormal_mitochondrial_morpho | 0.80096942 |
| 66 | MP0005187_abnormal_penis_morphology | 0.77769416 |
| 67 | MP0000579_abnormal_nail_morphology | 0.75123747 |
| 68 | MP0005075_abnormal_melanosome_morpholog | 0.74914250 |
| 69 | MP0003936_abnormal_reproductive_system | 0.73387845 |
| 70 | MP0001756_abnormal_urination | 0.69852239 |
| 71 | MP0000627_abnormal_mammary_gland | 0.69688244 |
| 72 | MP0005083_abnormal_biliary_tract | 0.68395751 |
| 73 | MP0005451_abnormal_body_composition | 0.66428279 |
| 74 | MP0005636_abnormal_mineral_homeostasis | 0.65884631 |
| 75 | MP0005330_cardiomyopathy | 0.65767938 |
| 76 | MP0003111_abnormal_nucleus_morphology | 0.65676222 |
| 77 | MP0003868_abnormal_feces_composition | 0.65145748 |
| 78 | MP0001216_abnormal_epidermal_layer | 0.64642865 |
| 79 | MP0005023_abnormal_wound_healing | 0.60913311 |
| 80 | MP0002693_abnormal_pancreas_physiology | 0.60866311 |
| 81 | MP0001963_abnormal_hearing_physiology | 0.60055384 |
| 82 | MP0001485_abnormal_pinna_reflex | 0.59591596 |
| 83 | MP0005319_abnormal_enzyme/_coenzyme | 0.55519152 |
| 84 | MP0010678_abnormal_skin_adnexa | 0.55404158 |
| 85 | MP0001765_abnormal_ion_homeostasis | 0.53947703 |
| 86 | MP0003786_premature_aging | 0.53559825 |
| 87 | MP0010771_integument_phenotype | 0.53117782 |
| 88 | MP0002210_abnormal_sex_determination | 0.52659194 |
| 89 | MP0005551_abnormal_eye_electrophysiolog | 0.51895386 |
| 90 | MP0000477_abnormal_intestine_morphology | 0.50779673 |
| 91 | MP0002136_abnormal_kidney_physiology | 0.50143566 |
| 92 | MP0005220_abnormal_exocrine_pancreas | 0.49687687 |
| 93 | MP0000377_abnormal_hair_follicle | 0.49108465 |
| 94 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.48779652 |
| 95 | MP0003252_abnormal_bile_duct | 0.48772484 |
| 96 | MP0005266_abnormal_metabolism | 0.48180307 |
| 97 | MP0000026_abnormal_inner_ear | 0.47844892 |
| 98 | MP0005395_other_phenotype | 0.47516007 |
| 99 | MP0000367_abnormal_coat/_hair | 0.46892996 |
| 100 | MP0001730_embryonic_growth_arrest | 0.46322440 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Brittle hair (HP:0002299) | 4.89179901 |
| 2 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.95213371 |
| 3 | Hypotrichosis (HP:0001006) | 3.73022129 |
| 4 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.65293172 |
| 5 | Abnormality of methionine metabolism (HP:0010901) | 3.65240572 |
| 6 | Steatorrhea (HP:0002570) | 3.61695397 |
| 7 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.51511813 |
| 8 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.49967871 |
| 9 | Absent/shortened dynein arms (HP:0200106) | 3.49967871 |
| 10 | Hydroxyprolinuria (HP:0003080) | 3.39408691 |
| 11 | Abnormality of proline metabolism (HP:0010907) | 3.39408691 |
| 12 | Anosmia (HP:0000458) | 3.37270222 |
| 13 | Ileus (HP:0002595) | 3.24992768 |
| 14 | Pigmentary retinal degeneration (HP:0001146) | 3.13696885 |
| 15 | Type I transferrin isoform profile (HP:0003642) | 3.10727295 |
| 16 | Hypokinesia (HP:0002375) | 3.04804809 |
| 17 | Fat malabsorption (HP:0002630) | 2.93502437 |
| 18 | Mitochondrial inheritance (HP:0001427) | 2.81646016 |
| 19 | Acute necrotizing encephalopathy (HP:0006965) | 2.80644997 |
| 20 | Acute encephalopathy (HP:0006846) | 2.80087080 |
| 21 | Aplastic anemia (HP:0001915) | 2.79492463 |
| 22 | Hypoproteinemia (HP:0003075) | 2.69046749 |
| 23 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.65600631 |
| 24 | Trismus (HP:0000211) | 2.65074366 |
| 25 | Entropion (HP:0000621) | 2.61796268 |
| 26 | Amelogenesis imperfecta (HP:0000705) | 2.61334570 |
| 27 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.58054619 |
| 28 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.58054619 |
| 29 | Rectal prolapse (HP:0002035) | 2.56958924 |
| 30 | Reduced antithrombin III activity (HP:0001976) | 2.56384503 |
| 31 | Sparse eyelashes (HP:0000653) | 2.55217818 |
| 32 | Abnormal hair laboratory examination (HP:0003328) | 2.51523198 |
| 33 | Tongue fasciculations (HP:0001308) | 2.50502238 |
| 34 | Hyperammonemia (HP:0001987) | 2.50262530 |
| 35 | Intrahepatic cholestasis (HP:0001406) | 2.48914723 |
| 36 | Unilateral renal agenesis (HP:0000122) | 2.48249111 |
| 37 | Male infertility (HP:0003251) | 2.47404665 |
| 38 | Confusion (HP:0001289) | 2.41672663 |
| 39 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.37095082 |
| 40 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.37095082 |
| 41 | Abnormal protein glycosylation (HP:0012346) | 2.37095082 |
| 42 | Abnormal glycosylation (HP:0012345) | 2.37095082 |
| 43 | Abnormality of purine metabolism (HP:0004352) | 2.35323329 |
| 44 | Lethargy (HP:0001254) | 2.34101009 |
| 45 | Increased CSF lactate (HP:0002490) | 2.33722323 |
| 46 | Paraparesis (HP:0002385) | 2.30585083 |
| 47 | Muscle fibrillation (HP:0010546) | 2.30258433 |
| 48 | Lactic acidosis (HP:0003128) | 2.28160483 |
| 49 | Cerebral edema (HP:0002181) | 2.24336727 |
| 50 | Decreased subcutaneous fat (HP:0001002) | 2.24118836 |
| 51 | Lipid accumulation in hepatocytes (HP:0006561) | 2.22315183 |
| 52 | Hepatocellular necrosis (HP:0001404) | 2.21786506 |
| 53 | Erythema (HP:0010783) | 2.21598023 |
| 54 | Vascular calcification (HP:0004934) | 2.21154042 |
| 55 | Abnormal number of erythroid precursors (HP:0012131) | 2.19302582 |
| 56 | Nail dystrophy (HP:0008404) | 2.19071328 |
| 57 | Abnormality of nucleobase metabolism (HP:0010932) | 2.16062778 |
| 58 | Aqueductal stenosis (HP:0002410) | 2.14849448 |
| 59 | Abnormality of homocysteine metabolism (HP:0010919) | 2.14214107 |
| 60 | Homocystinuria (HP:0002156) | 2.14214107 |
| 61 | Abnormality of vitamin metabolism (HP:0100508) | 2.10064127 |
| 62 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.10049905 |
| 63 | 3-Methylglutaconic aciduria (HP:0003535) | 2.08782308 |
| 64 | Opisthotonus (HP:0002179) | 2.08719890 |
| 65 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.08661227 |
| 66 | Vacuolated lymphocytes (HP:0001922) | 2.08591313 |
| 67 | Hepatic necrosis (HP:0002605) | 2.07535871 |
| 68 | Chronic otitis media (HP:0000389) | 2.05958648 |
| 69 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.05393539 |
| 70 | Abnormality of the right ventricle (HP:0001707) | 2.03239625 |
| 71 | True hermaphroditism (HP:0010459) | 2.03018005 |
| 72 | Progressive macrocephaly (HP:0004481) | 2.02967794 |
| 73 | Abnormality of vitamin B metabolism (HP:0004340) | 2.01013016 |
| 74 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.99657990 |
| 75 | Absent thumb (HP:0009777) | 1.98171168 |
| 76 | Abnormality of serum amino acid levels (HP:0003112) | 1.97998077 |
| 77 | Septate vagina (HP:0001153) | 1.97617726 |
| 78 | Dry hair (HP:0011359) | 1.97400141 |
| 79 | Dicarboxylic aciduria (HP:0003215) | 1.96833991 |
| 80 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.96833991 |
| 81 | Tetraparesis (HP:0002273) | 1.96291215 |
| 82 | Cerebral palsy (HP:0100021) | 1.95872532 |
| 83 | Spastic paraparesis (HP:0002313) | 1.95768138 |
| 84 | Aplasia cutis congenita (HP:0001057) | 1.95146077 |
| 85 | Abnormal spermatogenesis (HP:0008669) | 1.94960635 |
| 86 | Palpitations (HP:0001962) | 1.94473717 |
| 87 | Hypogonadotrophic hypogonadism (HP:0000044) | 1.94405406 |
| 88 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.94311334 |
| 89 | Mutism (HP:0002300) | 1.91676452 |
| 90 | Large for gestational age (HP:0001520) | 1.89487811 |
| 91 | Increased serum lactate (HP:0002151) | 1.88581315 |
| 92 | Partial agenesis of the corpus callosum (HP:0001338) | 1.87625984 |
| 93 | Upper limb amyotrophy (HP:0009129) | 1.86727922 |
| 94 | Distal upper limb amyotrophy (HP:0007149) | 1.86727922 |
| 95 | Concave nail (HP:0001598) | 1.85156491 |
| 96 | Increased hepatocellular lipid droplets (HP:0006565) | 1.84944223 |
| 97 | Exocrine pancreatic insufficiency (HP:0001738) | 1.81940288 |
| 98 | Rough bone trabeculation (HP:0100670) | 1.81778206 |
| 99 | Progressive sensorineural hearing impairment (HP:0000408) | 1.81438222 |
| 100 | Nausea (HP:0002018) | 1.78519838 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TLK1 | 5.57176437 |
| 2 | ZAK | 5.46877890 |
| 3 | LMTK2 | 5.07529323 |
| 4 | EPHA2 | 4.70997456 |
| 5 | BUB1 | 3.95976871 |
| 6 | NEK1 | 3.54177095 |
| 7 | MAP3K12 | 3.08666082 |
| 8 | TXK | 3.07518115 |
| 9 | SCYL2 | 2.71961205 |
| 10 | VRK1 | 2.45774366 |
| 11 | PBK | 2.19734204 |
| 12 | STK16 | 2.17030989 |
| 13 | MST1R | 2.15569308 |
| 14 | SMG1 | 2.15208039 |
| 15 | VRK2 | 1.94642388 |
| 16 | TESK1 | 1.68720304 |
| 17 | ADRBK2 | 1.59079060 |
| 18 | MST4 | 1.57037391 |
| 19 | MAP3K3 | 1.55082496 |
| 20 | PASK | 1.46778141 |
| 21 | MYLK | 1.44319705 |
| 22 | LIMK1 | 1.42453384 |
| 23 | TAF1 | 1.23004744 |
| 24 | TESK2 | 1.17586888 |
| 25 | NLK | 1.15788589 |
| 26 | AURKA | 1.15363170 |
| 27 | PDK2 | 1.05215791 |
| 28 | KDR | 1.05022613 |
| 29 | RPS6KB2 | 1.01595954 |
| 30 | FER | 1.01106847 |
| 31 | BLK | 0.99415156 |
| 32 | DAPK3 | 0.98349101 |
| 33 | PRKG2 | 0.96276617 |
| 34 | EIF2AK3 | 0.95922556 |
| 35 | MAP3K11 | 0.94254375 |
| 36 | MAPKAPK3 | 0.86511722 |
| 37 | MET | 0.85721216 |
| 38 | NUAK1 | 0.85604554 |
| 39 | PAK4 | 0.80651152 |
| 40 | GRK1 | 0.78481137 |
| 41 | RPS6KA5 | 0.74979159 |
| 42 | BCKDK | 0.73562086 |
| 43 | EPHA3 | 0.70674244 |
| 44 | STK39 | 0.70413762 |
| 45 | ROCK1 | 0.68824815 |
| 46 | DAPK1 | 0.66342548 |
| 47 | STK10 | 0.65283563 |
| 48 | CDK9 | 0.61152152 |
| 49 | RPS6KA4 | 0.58326520 |
| 50 | GRK7 | 0.55239079 |
| 51 | WNK4 | 0.54408155 |
| 52 | PIM2 | 0.53616387 |
| 53 | RIPK4 | 0.53224488 |
| 54 | ARAF | 0.51881101 |
| 55 | CCNB1 | 0.50769186 |
| 56 | ABL2 | 0.50720122 |
| 57 | AKT2 | 0.50384994 |
| 58 | TSSK6 | 0.48209544 |
| 59 | AURKB | 0.47257660 |
| 60 | PAK1 | 0.45553264 |
| 61 | EPHB1 | 0.45185976 |
| 62 | EPHA4 | 0.40516840 |
| 63 | NME2 | 0.38363801 |
| 64 | OXSR1 | 0.37473811 |
| 65 | PTK6 | 0.37167944 |
| 66 | MAP3K1 | 0.36818775 |
| 67 | TNIK | 0.35990344 |
| 68 | ITK | 0.35511821 |
| 69 | PLK1 | 0.35247791 |
| 70 | STK4 | 0.35189518 |
| 71 | PTK2B | 0.34988177 |
| 72 | PTK2 | 0.34762642 |
| 73 | MAP2K7 | 0.34341554 |
| 74 | PRKCI | 0.32874985 |
| 75 | EIF2AK1 | 0.31492414 |
| 76 | PRKCQ | 0.30900239 |
| 77 | MAP3K8 | 0.30388614 |
| 78 | DYRK2 | 0.29674020 |
| 79 | PKN1 | 0.27990723 |
| 80 | ADRBK1 | 0.27854496 |
| 81 | MAPKAPK5 | 0.27628391 |
| 82 | CDC7 | 0.27181570 |
| 83 | IKBKE | 0.27139946 |
| 84 | CHEK2 | 0.26607792 |
| 85 | MAP2K3 | 0.25371210 |
| 86 | CAMK2G | 0.24341078 |
| 87 | BRSK1 | 0.21327624 |
| 88 | CSNK1G3 | 0.21104548 |
| 89 | TBK1 | 0.20321354 |
| 90 | EIF2AK2 | 0.18774411 |
| 91 | CDK19 | 0.18093924 |
| 92 | PHKG2 | 0.17772553 |
| 93 | PHKG1 | 0.17772553 |
| 94 | ILK | 0.17034952 |
| 95 | WEE1 | 0.16581928 |
| 96 | GRK5 | 0.16192993 |
| 97 | PRKCA | 0.15415099 |
| 98 | CAMK2D | 0.14897816 |
| 99 | CDK8 | 0.14661090 |
| 100 | MAP2K1 | 0.14286285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.61837398 |
| 2 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 3.37227725 |
| 3 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 2.65491447 |
| 4 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.39869733 |
| 5 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.36463425 |
| 6 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.28963675 |
| 7 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.19981480 |
| 8 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.17530141 |
| 9 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.08200999 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.03397008 |
| 11 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.97751821 |
| 12 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.96278398 |
| 13 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.85444889 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.81385965 |
| 15 | Alcoholism_Homo sapiens_hsa05034 | 1.80973666 |
| 16 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.80008814 |
| 17 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.75221929 |
| 18 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.73977959 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.69525560 |
| 20 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.63916395 |
| 21 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.61522484 |
| 22 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.55071276 |
| 23 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.52952287 |
| 24 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.40508058 |
| 25 | Carbon metabolism_Homo sapiens_hsa01200 | 1.36494689 |
| 26 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.34632671 |
| 27 | Ribosome_Homo sapiens_hsa03010 | 1.31838760 |
| 28 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.29733466 |
| 29 | Parkinsons disease_Homo sapiens_hsa05012 | 1.29703806 |
| 30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.29180117 |
| 31 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.27976728 |
| 32 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.24974111 |
| 33 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.21478571 |
| 34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.19915135 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.19085135 |
| 36 | RNA polymerase_Homo sapiens_hsa03020 | 1.18508458 |
| 37 | Galactose metabolism_Homo sapiens_hsa00052 | 1.15999838 |
| 38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.15969437 |
| 39 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.15112022 |
| 40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.14240601 |
| 41 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.13670573 |
| 42 | Sulfur relay system_Homo sapiens_hsa04122 | 1.13408383 |
| 43 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.11330320 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.10458035 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.04565223 |
| 46 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.03558378 |
| 47 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.02373093 |
| 48 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.99423603 |
| 49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.98987312 |
| 50 | Purine metabolism_Homo sapiens_hsa00230 | 0.98540634 |
| 51 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.95657929 |
| 52 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.93030442 |
| 53 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.93017273 |
| 54 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.91356836 |
| 55 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.89981010 |
| 56 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.88763160 |
| 57 | DNA replication_Homo sapiens_hsa03030 | 0.88344942 |
| 58 | Spliceosome_Homo sapiens_hsa03040 | 0.87055654 |
| 59 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.86964978 |
| 60 | Huntingtons disease_Homo sapiens_hsa05016 | 0.85902341 |
| 61 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.85349089 |
| 62 | Mismatch repair_Homo sapiens_hsa03430 | 0.82025611 |
| 63 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.80497344 |
| 64 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.80368926 |
| 65 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.78567409 |
| 66 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.77097631 |
| 67 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.76745675 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.76729726 |
| 69 | Alzheimers disease_Homo sapiens_hsa05010 | 0.76352713 |
| 70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75585947 |
| 71 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.75556390 |
| 72 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.74839785 |
| 73 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.72400807 |
| 74 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.71889966 |
| 75 | Tight junction_Homo sapiens_hsa04530 | 0.71570258 |
| 76 | Phototransduction_Homo sapiens_hsa04744 | 0.66486456 |
| 77 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.64287884 |
| 78 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.63995462 |
| 79 | Peroxisome_Homo sapiens_hsa04146 | 0.62600028 |
| 80 | Basal transcription factors_Homo sapiens_hsa03022 | 0.57071411 |
| 81 | ABC transporters_Homo sapiens_hsa02010 | 0.56985452 |
| 82 | Retinol metabolism_Homo sapiens_hsa00830 | 0.55427440 |
| 83 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.52186059 |
| 84 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.49003975 |
| 85 | Bile secretion_Homo sapiens_hsa04976 | 0.48680489 |
| 86 | Base excision repair_Homo sapiens_hsa03410 | 0.48223548 |
| 87 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47811729 |
| 88 | Mineral absorption_Homo sapiens_hsa04978 | 0.46757444 |
| 89 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.46001235 |
| 90 | Histidine metabolism_Homo sapiens_hsa00340 | 0.45933307 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.44727400 |
| 92 | Other glycan degradation_Homo sapiens_hsa00511 | 0.43073622 |
| 93 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.42726081 |
| 94 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.42094131 |
| 95 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.41680259 |
| 96 | Homologous recombination_Homo sapiens_hsa03440 | 0.41187634 |
| 97 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.38729935 |
| 98 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35082964 |
| 99 | RNA transport_Homo sapiens_hsa03013 | 0.34789334 |
| 100 | RNA degradation_Homo sapiens_hsa03018 | 0.34630975 |

