KRT8P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.35982750
2desmosome organization (GO:0002934)5.53756226
3protein maturation by protein folding (GO:0022417)5.18148517
4nuclear envelope reassembly (GO:0031468)4.99815017
5mitotic nuclear envelope reassembly (GO:0007084)4.99815017
6COPI coating of Golgi vesicle (GO:0048205)4.75756064
7Golgi transport vesicle coating (GO:0048200)4.75756064
8establishment of integrated proviral latency (GO:0075713)4.37641617
9establishment of viral latency (GO:0019043)4.29346271
10proteasome assembly (GO:0043248)3.88065712
11regulation of translational termination (GO:0006449)3.87441284
12positive regulation of epidermal cell differentiation (GO:0045606)3.75868135
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.73463220
14deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.71619812
15bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67553763
16AMP metabolic process (GO:0046033)3.65654418
17membrane raft organization (GO:0031579)3.55451304
18regulation of metalloenzyme activity (GO:0048552)3.54938573
19positive regulation of actin filament depolymerization (GO:0030836)3.54290095
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52405573
21protein retention in ER lumen (GO:0006621)3.43768002
22positive regulation of pseudopodium assembly (GO:0031274)3.43218466
23GDP-mannose metabolic process (GO:0019673)3.38391492
24hair cycle (GO:0042633)3.31144711
25molting cycle (GO:0042303)3.31144711
26ADP metabolic process (GO:0046031)3.29914183
27galactose catabolic process (GO:0019388)3.27662874
28polyketide metabolic process (GO:0030638)3.27495699
29doxorubicin metabolic process (GO:0044598)3.27495699
30daunorubicin metabolic process (GO:0044597)3.27495699
31muscle cell migration (GO:0014812)3.25693309
32nucleobase-containing small molecule interconversion (GO:0015949)3.23023328
33galactose metabolic process (GO:0006012)3.20267950
34pyrimidine nucleoside salvage (GO:0043097)3.14042068
35pyrimidine-containing compound salvage (GO:0008655)3.14042068
36prostaglandin biosynthetic process (GO:0001516)3.13839131
37prostanoid biosynthetic process (GO:0046457)3.13839131
38positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.12605620
39negative regulation of keratinocyte proliferation (GO:0010839)3.10966712
40regulation of cellular amino acid metabolic process (GO:0006521)3.09167502
41actin filament depolymerization (GO:0030042)3.08672651
42morphogenesis of an endothelium (GO:0003159)3.06836124
43endothelial tube morphogenesis (GO:0061154)3.06836124
44lipopolysaccharide biosynthetic process (GO:0009103)3.05490246
45regulation of water loss via skin (GO:0033561)3.02093692
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.01092468
47protein heterotetramerization (GO:0051290)3.00838674
48regulation of pseudopodium assembly (GO:0031272)2.98553785
49positive regulation of epidermis development (GO:0045684)2.98402200
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94424896
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93522398
52L-phenylalanine metabolic process (GO:0006558)2.93522398
53ribosome assembly (GO:0042255)2.93242089
54mesonephros development (GO:0001823)2.92151364
55establishment of skin barrier (GO:0061436)2.89939502
56aminoglycoside antibiotic metabolic process (GO:0030647)2.86321156
57protein autoprocessing (GO:0016540)2.85894306
58protein localization to endosome (GO:0036010)2.83878552
59type B pancreatic cell proliferation (GO:0044342)2.83362442
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83310384
61cell adhesion mediated by integrin (GO:0033627)2.80375283
62negative regulation of ligase activity (GO:0051352)2.76554380
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76554380
64nucleoside salvage (GO:0043174)2.75851306
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.74995213
66negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.71926826
67cyclooxygenase pathway (GO:0019371)2.71106077
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70988060
69cell-substrate junction assembly (GO:0007044)2.70184051
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69566799
71glucose catabolic process (GO:0006007)2.66048101
72tRNA methylation (GO:0030488)2.65710621
73nucleotide-sugar biosynthetic process (GO:0009226)2.64908815
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64726576
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63815108
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63815108
77signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63483045
78signal transduction involved in DNA damage checkpoint (GO:0072422)2.63483045
79DNA unwinding involved in DNA replication (GO:0006268)2.62726405
80positive regulation of DNA-dependent DNA replication (GO:2000105)2.60307230
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59344905
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59344905
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59344905
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58940148
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.55549512
86negative regulation of T cell differentiation in thymus (GO:0033085)2.55412223
87regulation of mitochondrial translation (GO:0070129)2.54639053
88pentose-phosphate shunt (GO:0006098)2.54023541
89regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.52210556
90mesodermal cell differentiation (GO:0048333)2.52075160
91cellular copper ion homeostasis (GO:0006878)2.51941651
92membrane budding (GO:0006900)2.51253349
93hepatocyte apoptotic process (GO:0097284)2.50787061
94negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.46433548
95barbed-end actin filament capping (GO:0051016)2.44391942
96activation of Rac GTPase activity (GO:0032863)2.43684540
97cobalamin metabolic process (GO:0009235)2.43413148
98cellular response to virus (GO:0098586)2.41061249
99xenobiotic catabolic process (GO:0042178)2.40678604
100ribosomal large subunit biogenesis (GO:0042273)2.39522035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.65900704
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.59040714
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.62997813
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.47830567
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93027726
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89962243
7ZNF263_19887448_ChIP-Seq_K562_Human2.55981060
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42519621
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.29856370
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27009291
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26074072
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17858394
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11394414
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08360429
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07348168
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07348168
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04184252
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04074375
19ATF3_27146783_Chip-Seq_COLON_Human2.03597933
20ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.90556382
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87616037
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86478411
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82465478
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.80885510
25DCP1A_22483619_ChIP-Seq_HELA_Human1.79480441
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.76960203
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75146032
28RACK7_27058665_Chip-Seq_MCF-7_Human1.75126171
29HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.73570844
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71663110
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.70618180
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69784814
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.66904008
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62468208
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60684111
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60055676
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.59432623
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.58117176
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58072930
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.56348769
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50218189
42XRN2_22483619_ChIP-Seq_HELA_Human1.48651563
43AR_21909140_ChIP-Seq_LNCAP_Human1.43544129
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41688089
45GABP_19822575_ChIP-Seq_HepG2_Human1.40205911
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38843570
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38284353
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37510342
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36388271
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.36339271
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36316836
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34862014
53GATA6_25053715_ChIP-Seq_YYC3_Human1.34805421
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34013704
55SOX2_20726797_ChIP-Seq_SW620_Human1.33587689
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32127350
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31690953
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31237090
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28828495
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28533816
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27749996
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26037206
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25757662
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.25246135
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23985692
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.23875466
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.23537154
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23175397
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21512142
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21468635
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21462556
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21423415
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18147215
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17406928
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16398542
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14566292
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14369476
78LXR_22292898_ChIP-Seq_THP-1_Human1.14307711
79E2F7_22180533_ChIP-Seq_HELA_Human1.12404777
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12353254
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12185898
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11806456
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.11109269
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.08930225
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08333585
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08267648
87GATA4_25053715_ChIP-Seq_YYC3_Human1.06973136
88* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04943402
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02453667
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01780749
91CLOCK_20551151_ChIP-Seq_293T_Human1.00578347
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.00264056
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00236628
94ELF5_23300383_ChIP-Seq_T47D_Human0.99218030
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98126296
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97994625
97KDM5A_27292631_Chip-Seq_BREAST_Human0.97970088
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96901503
99P68_20966046_ChIP-Seq_HELA_Human0.93079322
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92494224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.30291182
2MP0002877_abnormal_melanocyte_morpholog3.98675589
3MP0003950_abnormal_plasma_membrane3.54185827
4MP0000579_abnormal_nail_morphology3.33667046
5MP0003806_abnormal_nucleotide_metabolis3.17448079
6MP0003566_abnormal_cell_adhesion3.16474071
7MP0003191_abnormal_cellular_cholesterol2.65910895
8MP0010030_abnormal_orbit_morphology2.62772474
9MP0002796_impaired_skin_barrier2.52718014
10MP0005451_abnormal_body_composition2.46087010
11MP0000762_abnormal_tongue_morphology2.36133732
12MP0000537_abnormal_urethra_morphology2.34632302
13MP0001216_abnormal_epidermal_layer2.18839649
14MP0005501_abnormal_skin_physiology2.18270874
15MP0005360_urolithiasis2.17564346
16MP0003315_abnormal_perineum_morphology2.07688818
17MP0002060_abnormal_skin_morphology2.07170338
18MP0004272_abnormal_basement_membrane2.04808759
19MP0005257_abnormal_intraocular_pressure1.99299604
20MP0010352_gastrointestinal_tract_polyps1.98659812
21MP0005023_abnormal_wound_healing1.98098021
22MP0005083_abnormal_biliary_tract1.97590137
23MP0009053_abnormal_anal_canal1.96898442
24MP0002098_abnormal_vibrissa_morphology1.90804747
25MP0003941_abnormal_skin_development1.84450464
26MP0003453_abnormal_keratinocyte_physiol1.84236625
27MP0000858_altered_metastatic_potential1.79576097
28MP0008875_abnormal_xenobiotic_pharmacok1.74368402
29MP0000467_abnormal_esophagus_morphology1.71842165
30MP0003693_abnormal_embryo_hatching1.69360488
31MP0000750_abnormal_muscle_regeneration1.65397378
32MP0009840_abnormal_foam_cell1.63625529
33MP0009780_abnormal_chondrocyte_physiolo1.59961291
34MP0002234_abnormal_pharynx_morphology1.52914108
35MP0010771_integument_phenotype1.52698913
36MP0004957_abnormal_blastocyst_morpholog1.47395754
37MP0005165_increased_susceptibility_to1.46416455
38MP0000566_synostosis1.46155685
39MP0010678_abnormal_skin_adnexa1.45837781
40MP0001849_ear_inflammation1.35579575
41MP0008260_abnormal_autophagy1.32292469
42MP0004264_abnormal_extraembryonic_tissu1.30890001
43MP0005330_cardiomyopathy1.28114189
44MP0001666_abnormal_nutrient_absorption1.27073059
45MP0003195_calcinosis1.26219863
46MP0003705_abnormal_hypodermis_morpholog1.22905504
47MP0005623_abnormal_meninges_morphology1.19580009
48MP0003786_premature_aging1.17955250
49MP0001243_abnormal_dermal_layer1.14512162
50MP0000627_abnormal_mammary_gland1.09639305
51MP0003111_abnormal_nucleus_morphology1.08983425
52MP0000377_abnormal_hair_follicle1.08024631
53MP0000613_abnormal_salivary_gland1.06170128
54MP0000751_myopathy1.05035541
55MP0000462_abnormal_digestive_system1.03584353
56MP0000003_abnormal_adipose_tissue1.01687220
57MP0000358_abnormal_cell_content/1.00964206
58MP0003638_abnormal_response/metabolism_0.99747037
59MP0008932_abnormal_embryonic_tissue0.98946939
60MP0008775_abnormal_heart_ventricle0.98138569
61MP0006054_spinal_hemorrhage0.97159013
62MP0000749_muscle_degeneration0.96677437
63MP0000490_abnormal_crypts_of0.96441599
64MP0010368_abnormal_lymphatic_system0.95684274
65MP0001542_abnormal_bone_strength0.95260236
66MP0005197_abnormal_uvea_morphology0.92744407
67MP0003186_abnormal_redox_activity0.91804407
68MP0004947_skin_inflammation0.89417945
69MP0002163_abnormal_gland_morphology0.88835507
70MP0008007_abnormal_cellular_replicative0.88672137
71MP0000383_abnormal_hair_follicle0.88593685
72MP0002282_abnormal_trachea_morphology0.88111923
73MP0001340_abnormal_eyelid_morphology0.86614975
74MP0001881_abnormal_mammary_gland0.85626862
75MP0009931_abnormal_skin_appearance0.83358773
76MP0003077_abnormal_cell_cycle0.81877612
77MP0001730_embryonic_growth_arrest0.79247286
78MP0005058_abnormal_lysosome_morphology0.78645848
79MP0009643_abnormal_urine_homeostasis0.78458990
80MP0004019_abnormal_vitamin_homeostasis0.77502533
81MP0009333_abnormal_splenocyte_physiolog0.77170530
82MP0000367_abnormal_coat/_hair0.76607536
83MP0000350_abnormal_cell_proliferation0.73691198
84MP0005584_abnormal_enzyme/coenzyme_acti0.73396821
85MP0005084_abnormal_gallbladder_morpholo0.71578819
86MP0000013_abnormal_adipose_tissue0.70153167
87MP0000647_abnormal_sebaceous_gland0.69314249
88MP0005275_abnormal_skin_tensile0.69289047
89MP0008438_abnormal_cutaneous_collagen0.68329750
90MP0001661_extended_life_span0.67925679
91MP0000747_muscle_weakness0.67301174
92MP0010094_abnormal_chromosome_stability0.64935607
93MP0003123_paternal_imprinting0.63987208
94MP0002080_prenatal_lethality0.63953662
95MP0002177_abnormal_outer_ear0.63583702
96MP0003866_abnormal_defecation0.63178856
97MP0005332_abnormal_amino_acid0.62014658
98MP0005408_hypopigmentation0.61263192
99MP0005395_other_phenotype0.60133768
100MP0003075_altered_response_to0.59939948

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.00538992
2Nail dystrophy (HP:0008404)4.18968379
3Vascular calcification (HP:0004934)4.17483037
4Fragile nails (HP:0001808)3.98363700
5Milia (HP:0001056)3.92217366
6Atrophic scars (HP:0001075)3.90865812
7Sparse eyelashes (HP:0000653)3.84306973
8Right ventricular cardiomyopathy (HP:0011663)3.73111363
9Abnormality of the distal phalanges of the toes (HP:0010182)3.71526015
10Cardiovascular calcification (HP:0011915)3.68880116
11Pili torti (HP:0003777)3.59869610
12Plantar hyperkeratosis (HP:0007556)3.54810403
13Short nail (HP:0001799)3.53962061
14Glucose intolerance (HP:0000833)3.30436818
15Abnormal hair laboratory examination (HP:0003328)3.26948606
16Premature rupture of membranes (HP:0001788)3.25253748
17Hypotrichosis (HP:0001006)3.23492091
18Reduced subcutaneous adipose tissue (HP:0003758)3.21724052
19Distal lower limb muscle weakness (HP:0009053)3.18073224
20Rough bone trabeculation (HP:0100670)3.13259073
21Brittle hair (HP:0002299)2.96243802
22Alopecia of scalp (HP:0002293)2.88646716
23Upper limb muscle weakness (HP:0003484)2.86990345
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.82536243
25Osteolytic defects of the hand bones (HP:0009699)2.82536243
26Trismus (HP:0000211)2.79718882
27Ileus (HP:0002595)2.71477866
28Glomerulosclerosis (HP:0000096)2.70414224
29Thick nail (HP:0001805)2.69602806
30Distal lower limb amyotrophy (HP:0008944)2.68375662
31Focal segmental glomerulosclerosis (HP:0000097)2.60745967
32Hepatocellular necrosis (HP:0001404)2.55641818
33Abnormal blistering of the skin (HP:0008066)2.53766534
34Hepatic necrosis (HP:0002605)2.52600123
35Micronodular cirrhosis (HP:0001413)2.45812444
36Acanthosis nigricans (HP:0000956)2.45639795
37Natal tooth (HP:0000695)2.44852202
38Limb-girdle muscle atrophy (HP:0003797)2.37608910
39Palmoplantar hyperkeratosis (HP:0000972)2.36855476
40Selective tooth agenesis (HP:0001592)2.34985113
41Abnormal trabecular bone morphology (HP:0100671)2.34675432
42Adrenal hypoplasia (HP:0000835)2.29199775
43Vertebral compression fractures (HP:0002953)2.21220290
44Entropion (HP:0000621)2.18822944
45Abnormality of glycolysis (HP:0004366)2.16688843
46Testicular atrophy (HP:0000029)2.15836094
47Insulin resistance (HP:0000855)2.14456519
48Cholecystitis (HP:0001082)2.13788851
49Abnormal gallbladder physiology (HP:0012438)2.13788851
50Palpitations (HP:0001962)2.13095317
51Palmar hyperkeratosis (HP:0010765)2.12935256
52Lower limb amyotrophy (HP:0007210)2.12061029
53Abnormal glucose tolerance (HP:0001952)2.10394792
54Abnormality of the umbilical cord (HP:0010881)2.09736741
55Hypoplasia of the uterus (HP:0000013)2.08685893
56Hyperuricemia (HP:0002149)2.03348580
57Increased purine levels (HP:0004368)2.03348580
58Type I transferrin isoform profile (HP:0003642)2.02986431
59Achilles tendon contracture (HP:0001771)2.02653480
60Increased serum pyruvate (HP:0003542)2.01129219
61Fragile skin (HP:0001030)1.99768748
62Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99316832
63Abnormalities of placenta or umbilical cord (HP:0001194)1.97917394
64Secondary amenorrhea (HP:0000869)1.97501157
65Increased connective tissue (HP:0009025)1.97428120
66Difficulty climbing stairs (HP:0003551)1.97014076
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96126385
68Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96126385
69Abnormality of nail color (HP:0100643)1.95123506
70Congenital, generalized hypertrichosis (HP:0004540)1.93899052
71Death in infancy (HP:0001522)1.93024919
72Congenital ichthyosiform erythroderma (HP:0007431)1.92150971
73Hypokinesia (HP:0002375)1.89539636
74Ridged nail (HP:0001807)1.89119750
75Hyperacusis (HP:0010780)1.89006725
76Hypoplasia of dental enamel (HP:0006297)1.87496940
77Amyloidosis (HP:0011034)1.87462583
78Interstitial pulmonary disease (HP:0006530)1.86660160
79Axonal loss (HP:0003447)1.86285495
80Myocardial infarction (HP:0001658)1.85667756
81Neoplasm of head and neck (HP:0012288)1.85638704
82Esophageal neoplasm (HP:0100751)1.85638704
83Ureteral duplication (HP:0000073)1.84385366
84Abnormality of proline metabolism (HP:0010907)1.84317229
85Hydroxyprolinuria (HP:0003080)1.84317229
86Prolonged neonatal jaundice (HP:0006579)1.84058119
87Abnormality of the Achilles tendon (HP:0005109)1.83061289
88Hypophosphatemic rickets (HP:0004912)1.83039334
89Distal upper limb amyotrophy (HP:0007149)1.82924299
90Upper limb amyotrophy (HP:0009129)1.82924299
91Abnormal mitochondria in muscle tissue (HP:0008316)1.82796024
92Microglossia (HP:0000171)1.81825801
93Deviation of the thumb (HP:0009603)1.80953924
94Unilateral renal agenesis (HP:0000122)1.79987061
95Renal Fanconi syndrome (HP:0001994)1.78626811
96Mitochondrial inheritance (HP:0001427)1.78414766
97Delayed CNS myelination (HP:0002188)1.78187857
98Progressive muscle weakness (HP:0003323)1.78128766
99Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77562127
100Erythema (HP:0010783)1.76545716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.34679267
2VRK24.02469627
3MST1R3.97786360
4TESK13.85553743
5NME23.76295640
6LIMK13.02327369
7TESK22.81293438
8LMTK22.65318331
9BUB12.61176615
10ARAF2.56619130
11IRAK32.42983547
12PAK42.36936277
13MET2.17340587
14EPHB12.01973687
15MAP3K121.93427516
16NEK11.80361315
17MST41.69716580
18SMG11.68722342
19PIM21.67876813
20PTK21.66389151
21ERN11.60576400
22PBK1.39488012
23SIK31.35754690
24ERBB41.35245675
25DAPK11.22773932
26ILK1.20184562
27MAPKAPK31.16985670
28EPHB21.14423442
29BCKDK1.11679656
30VRK11.09051034
31STK101.08251733
32RPS6KB21.02676780
33MYLK0.98197644
34MAP3K30.98078820
35ABL20.95001189
36TRIB30.94816846
37FER0.92307841
38SIK10.89825681
39PRKCI0.86140430
40SCYL20.83829219
41STK160.81520049
42PTK60.80974971
43CSNK1G30.79149735
44AURKA0.78672067
45CSNK1A1L0.76817575
46BRSK10.76490688
47MAP3K90.76199196
48PHKG20.75182128
49PHKG10.75182128
50EPHA30.74092023
51TAF10.72153591
52CDK80.71076061
53KDR0.69708222
54AURKB0.68538502
55SRPK10.68307331
56EIF2AK10.67585133
57BRAF0.67293144
58NME10.66190792
59TAOK20.65270262
60TRIM280.65070735
61TTN0.64343431
62DAPK30.62186173
63CAMK2G0.59670156
64FLT30.58828067
65MAP3K80.58120066
66PDK20.52431823
67MOS0.51241396
68RPS6KA40.50222802
69TLK10.50067299
70PAK10.50030180
71MAP2K70.49137729
72CSNK1G10.46469370
73HIPK20.46448531
74NTRK10.45889285
75CDK70.44463175
76PRKG20.44385054
77PTK2B0.44161692
78RIPK10.43186234
79MAPKAPK20.39283485
80TBK10.38994487
81STK380.38037746
82NEK20.37934812
83LRRK20.31557425
84AKT20.31013560
85IKBKB0.30268955
86CSNK1G20.28833219
87GRK50.27986333
88CDK90.27617550
89MAPK110.26826184
90CAMK2B0.26625681
91FGFR40.26625566
92LATS20.26455079
93MAP3K10.25925547
94PLK30.24246365
95PLK10.24238489
96TSSK60.23843816
97CAMK2D0.23674294
98MAP3K110.23282242
99MAP3K20.21412175
100ROCK20.21179897

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28124785
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.88110243
3DNA replication_Homo sapiens_hsa030302.81766369
4Galactose metabolism_Homo sapiens_hsa000522.50693777
5Pyrimidine metabolism_Homo sapiens_hsa002402.20215435
6Pentose phosphate pathway_Homo sapiens_hsa000302.19213151
7Biosynthesis of amino acids_Homo sapiens_hsa012302.17251978
8Sulfur relay system_Homo sapiens_hsa041222.15640191
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14925365
10Glutathione metabolism_Homo sapiens_hsa004801.94565337
11N-Glycan biosynthesis_Homo sapiens_hsa005101.89823239
12Sulfur metabolism_Homo sapiens_hsa009201.89547520
13Fructose and mannose metabolism_Homo sapiens_hsa000511.89433114
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.76334503
15Folate biosynthesis_Homo sapiens_hsa007901.74272306
16Mismatch repair_Homo sapiens_hsa034301.74262737
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70028600
18Base excision repair_Homo sapiens_hsa034101.69365673
19Fatty acid elongation_Homo sapiens_hsa000621.69006211
20Carbon metabolism_Homo sapiens_hsa012001.68919747
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67392663
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.66706814
23Vibrio cholerae infection_Homo sapiens_hsa051101.62959084
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62513551
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57622671
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54275196
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.46108203
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43689083
29Oxidative phosphorylation_Homo sapiens_hsa001901.42472832
30Pyruvate metabolism_Homo sapiens_hsa006201.40766755
31Nucleotide excision repair_Homo sapiens_hsa034201.40422574
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36196722
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33968716
34Ribosome_Homo sapiens_hsa030101.29238064
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28715210
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25393583
37Phenylalanine metabolism_Homo sapiens_hsa003601.24107067
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.18932723
39RNA polymerase_Homo sapiens_hsa030201.16812964
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13278397
41Shigellosis_Homo sapiens_hsa051311.12346079
42Starch and sucrose metabolism_Homo sapiens_hsa005001.09861007
43Parkinsons disease_Homo sapiens_hsa050121.07809559
44Thyroid cancer_Homo sapiens_hsa052161.06123781
45Chemical carcinogenesis_Homo sapiens_hsa052041.04403976
46Bladder cancer_Homo sapiens_hsa052191.03286730
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03216314
48Huntingtons disease_Homo sapiens_hsa050160.97550848
49Homologous recombination_Homo sapiens_hsa034400.96820610
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91458742
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90831747
52Renin-angiotensin system_Homo sapiens_hsa046140.90168029
53Alzheimers disease_Homo sapiens_hsa050100.90087389
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.89915486
55Small cell lung cancer_Homo sapiens_hsa052220.89387315
56Purine metabolism_Homo sapiens_hsa002300.89157894
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89006333
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87926067
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82254237
60Tight junction_Homo sapiens_hsa045300.81456963
61Tyrosine metabolism_Homo sapiens_hsa003500.81155308
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.80215054
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75754506
64Vitamin digestion and absorption_Homo sapiens_hsa049770.74423642
65Metabolic pathways_Homo sapiens_hsa011000.72356039
66One carbon pool by folate_Homo sapiens_hsa006700.72311743
67Spliceosome_Homo sapiens_hsa030400.71468988
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69158729
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67729623
70ECM-receptor interaction_Homo sapiens_hsa045120.65642200
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63686402
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62769493
73p53 signaling pathway_Homo sapiens_hsa041150.62610845
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62020093
75Apoptosis_Homo sapiens_hsa042100.61164719
76Selenocompound metabolism_Homo sapiens_hsa004500.59772809
77RNA transport_Homo sapiens_hsa030130.59402538
78Hepatitis C_Homo sapiens_hsa051600.56102037
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51946382
80Cell cycle_Homo sapiens_hsa041100.51559895
81Focal adhesion_Homo sapiens_hsa045100.51536445
82Steroid biosynthesis_Homo sapiens_hsa001000.50805105
83Arginine biosynthesis_Homo sapiens_hsa002200.49273447
84Hippo signaling pathway_Homo sapiens_hsa043900.48311802
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47087916
86Viral carcinogenesis_Homo sapiens_hsa052030.43733144
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.42716813
88Arginine and proline metabolism_Homo sapiens_hsa003300.40736340
89Lysosome_Homo sapiens_hsa041420.40011017
90Histidine metabolism_Homo sapiens_hsa003400.38161253
91Arachidonic acid metabolism_Homo sapiens_hsa005900.36505370
92Pancreatic cancer_Homo sapiens_hsa052120.35693692
93Fat digestion and absorption_Homo sapiens_hsa049750.35330136
94Protein digestion and absorption_Homo sapiens_hsa049740.34781495
95Proteoglycans in cancer_Homo sapiens_hsa052050.34490131
96Salmonella infection_Homo sapiens_hsa051320.34267021
97Endocytosis_Homo sapiens_hsa041440.33425249
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.33190858
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32938360
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32583803

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