ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	9.79895575
2	opioid receptor signaling pathway (GO:0038003)	9.16123255
3	negative regulation of cAMP-mediated signaling (GO:0043951)	8.79418228
4	ether lipid metabolic process (GO:0046485)	8.02055063
5	regulation of translational termination (GO:0006449)	7.59802690
6	behavioral response to ethanol (GO:0048149)	6.97875710
7	regulation of acrosome reaction (GO:0060046)	6.84505283
8	adult feeding behavior (GO:0008343)	6.71509925
9	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	6.47459105
10	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	6.43173535
11	thrombin receptor signaling pathway (GO:0070493)	6.22793610
12	regulation of protein glycosylation (GO:0060049)	6.19850293
13	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.86057581
14	positive regulation of cAMP-mediated signaling (GO:0043950)	5.79890946
15	piRNA metabolic process (GO:0034587)	5.62647702
16	negative regulation of nitric oxide biosynthetic process (GO:0045019)	5.17564142
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	5.15210720
18	glycerol ether metabolic process (GO:0006662)	5.15199227
19	sphingosine metabolic process (GO:0006670)	4.82407587
20	sphingoid metabolic process (GO:0046519)	4.78229069
21	ether metabolic process (GO:0018904)	4.74764824
22	negative regulation of glycoprotein biosynthetic process (GO:0010561)	4.71744509
23	diol metabolic process (GO:0034311)	4.56071085
24	notochord development (GO:0030903)	4.39145681
25	pyrimidine dimer repair (GO:0006290)	4.32517342
26	DNA replication-dependent nucleosome assembly (GO:0006335)	4.21182769
27	DNA replication-dependent nucleosome organization (GO:0034723)	4.21182769
28	transepithelial transport (GO:0070633)	3.83048073
29	mRNA cleavage (GO:0006379)	3.81719159
30	negative regulation of glycoprotein metabolic process (GO:1903019)	3.61828673
31	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.61050539
32	interferon-gamma secretion (GO:0072643)	3.59228509
33	regulation of translational elongation (GO:0006448)	3.56853917
34	aldehyde catabolic process (GO:0046185)	3.53468325
35	iron ion import (GO:0097286)	3.51462299
36	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.50641277
37	glutathione derivative metabolic process (GO:1901685)	3.48579088
38	glutathione derivative biosynthetic process (GO:1901687)	3.48579088
39	positive regulation of icosanoid secretion (GO:0032305)	3.47580474
40	vitamin catabolic process (GO:0009111)	3.43436705
41	fat-soluble vitamin catabolic process (GO:0042363)	3.43436705
42	xenobiotic catabolic process (GO:0042178)	3.40156166
43	regulation of cAMP-mediated signaling (GO:0043949)	3.36823392
44	positive regulation of fatty acid transport (GO:2000193)	3.36081222
45	cellular response to ammonium ion (GO:0071242)	3.35600206
46	chemical homeostasis within a tissue (GO:0048875)	3.32368454
47	replication fork processing (GO:0031297)	3.31157014
48	ncRNA catabolic process (GO:0034661)	3.16802462
49	protein heterotetramerization (GO:0051290)	3.16625843
50	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.15259363
51	coenzyme catabolic process (GO:0009109)	3.11252813
52	molting cycle (GO:0042303)	3.07255352
53	hair cycle (GO:0042633)	3.07255352
54	positive regulation of prostaglandin secretion (GO:0032308)	3.00214595
55	cellular ketone body metabolic process (GO:0046950)	3.00161462
56	signal complex assembly (GO:0007172)	2.95924937
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.95505948
58	glucosamine-containing compound catabolic process (GO:1901072)	2.93728690
59	glyoxylate metabolic process (GO:0046487)	2.92754071
60	cellular response to alkaloid (GO:0071312)	2.92688120
61	inner ear receptor cell development (GO:0060119)	2.92067915
62	glomerular visceral epithelial cell development (GO:0072015)	2.86608581
63	behavioral response to cocaine (GO:0048148)	2.83721644
64	DNA deamination (GO:0045006)	2.82974492
65	dopamine transport (GO:0015872)	2.80510198
66	wound healing, spreading of epidermal cells (GO:0035313)	2.79796610
67	ER overload response (GO:0006983)	2.79204004
68	glycosphingolipid metabolic process (GO:0006687)	2.78360202
69	proteasome assembly (GO:0043248)	2.75107820
70	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.72866717
71	dicarboxylic acid biosynthetic process (GO:0043650)	2.70681830
72	ovulation from ovarian follicle (GO:0001542)	2.70591049
73	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.68372278
74	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.65722239
75	DNA synthesis involved in DNA repair (GO:0000731)	2.65387112
76	regulation of glutamate receptor signaling pathway (GO:1900449)	2.64931975
77	placenta development (GO:0001890)	2.64796277
78	lactate metabolic process (GO:0006089)	2.61713799
79	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58757235
80	ketone body metabolic process (GO:1902224)	2.58139263
81	regulation of proton transport (GO:0010155)	2.58004019
82	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.57736687
83	sodium-independent organic anion transport (GO:0043252)	2.53833085
84	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.53147095
85	positive regulation of protein complex disassembly (GO:0043243)	2.53004410
86	detection of mechanical stimulus (GO:0050982)	2.51876347
87	ribonucleoprotein complex disassembly (GO:0032988)	2.51147800
88	serine family amino acid biosynthetic process (GO:0009070)	2.51125983
89	regulation of cellular amino acid metabolic process (GO:0006521)	2.49473729
90	negative regulation of adenylate cyclase activity (GO:0007194)	2.48884148
91	nephron epithelium morphogenesis (GO:0072088)	2.46714250
92	nephron tubule morphogenesis (GO:0072078)	2.46714250
93	negative regulation of cell-matrix adhesion (GO:0001953)	2.46524952
94	positive regulation of nitric oxide biosynthetic process (GO:0045429)	2.44387233
95	response to morphine (GO:0043278)	2.44301329
96	glycolipid metabolic process (GO:0006664)	2.44127439
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.44054267
98	urate metabolic process (GO:0046415)	2.43071912
99	dicarboxylic acid catabolic process (GO:0043649)	2.42794051
100	glomerular epithelial cell development (GO:0072310)	2.41264885

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.78852151
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.19586907
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.15592248
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.97250996
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91216156
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.79764033
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.77099446
8	RXR_22108803_ChIP-Seq_LS180_Human	2.71239017
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62734682
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.51915436
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.29056027
12	HTT_18923047_ChIP-ChIP_STHdh_Human	2.19125108
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.07886007
14	EGR1_19032775_ChIP-ChIP_M12_Human	2.05309856
15	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.00777432
16	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.98247293
17	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.96577437
18	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.95597877
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.87904048
20	NANOG_19829295_ChIP-Seq_ESCs_Human	1.87253162
21	SOX2_19829295_ChIP-Seq_ESCs_Human	1.87253162
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.85575184
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84318333
24	CDX2_22108803_ChIP-Seq_LS180_Human	1.80142827
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.79331106
26	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.76999336
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68581385
28	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.67482633
29	ELF5_23300383_ChIP-Seq_T47D_Human	1.66603544
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.65865499
31	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.65761980
32	GATA4_25053715_ChIP-Seq_YYC3_Human	1.64121167
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63822628
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63822628
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63600973
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.58269599
37	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.57059329
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56647429
39	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.56254510
40	TCF4_23295773_ChIP-Seq_U87_Human	1.48346383
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45642482
42	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.45531535
43	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.44880630
44	TP53_16413492_ChIP-PET_HCT116_Human	1.43233212
45	CBP_21632823_ChIP-Seq_H3396_Human	1.43129547
46	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.42960793
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.42076144
48	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.39710060
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.39659003
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.39536917
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39380659
52	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.38782708
53	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37200702
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36054977
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35255065
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.32522005
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32522005
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.32214019
59	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.27344705
60	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25102169
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24411323
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24411323
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23447790
64	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.22984076
65	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.17826109
66	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17700097
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.15673831
68	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.15329092
69	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14141124
70	GATA6_25053715_ChIP-Seq_YYC3_Human	1.11181266
71	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.10127559
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09449976
73	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07477872
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.05558430
75	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05285555
76	AR_20517297_ChIP-Seq_VCAP_Human	1.05264410
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.05000239
78	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.03221552
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02299433
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01833087
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01380010
82	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01176623
83	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.00903710
84	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00846966
85	STAT3_23295773_ChIP-Seq_U87_Human	0.99247653
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97311252
87	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.96391464
88	CJUN_26792858_Chip-Seq_BT549_Human	0.96294437
89	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.96207324
90	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.96073801
91	ERA_21632823_ChIP-Seq_H3396_Human	0.95745371
92	AHR_22903824_ChIP-Seq_MCF-7_Human	0.95524053
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95412406
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95116954
95	AR_21909140_ChIP-Seq_LNCAP_Human	0.94065631
96	GBX2_23144817_ChIP-Seq_PC3_Human	0.93305985
97	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.93115912
98	RAC3_21632823_ChIP-Seq_H3396_Human	0.92968614
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91010149
100	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90913887

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	7.70706147
2	MP0002876_abnormal_thyroid_physiology	5.42041046
3	MP0009278_abnormal_bone_marrow	3.78732808
4	MP0005360_urolithiasis	2.96638811
5	MP0000678_abnormal_parathyroid_gland	2.94766272
6	MP0005646_abnormal_pituitary_gland	2.92403750
7	MP0008057_abnormal_DNA_replication	2.76581342
8	MP0004147_increased_porphyrin_level	2.73033153
9	MP0001968_abnormal_touch/_nociception	2.70238981
10	MP0005503_abnormal_tendon_morphology	2.65822345
11	MP0003941_abnormal_skin_development	2.62787930
12	MP0009764_decreased_sensitivity_to	2.48448965
13	MP0001485_abnormal_pinna_reflex	2.32553620
14	MP0004381_abnormal_hair_follicle	2.24989726
15	MP0002254_reproductive_system_inflammat	2.14920590
16	MP0008875_abnormal_xenobiotic_pharmacok	2.12113868
17	MP0006035_abnormal_mitochondrial_morpho	2.04133354
18	MP0000681_abnormal_thyroid_gland	1.96915801
19	MP0005551_abnormal_eye_electrophysiolog	1.93511442
20	MP0008872_abnormal_physiological_respon	1.85845385
21	MP0000427_abnormal_hair_cycle	1.83046985
22	MP0005645_abnormal_hypothalamus_physiol	1.79196671
23	MP0009697_abnormal_copulation	1.76055439
24	MP0003045_fibrosis	1.72602307
25	MP0003868_abnormal_feces_composition	1.72449264
26	MP0003195_calcinosis	1.72239265
27	MP0004043_abnormal_pH_regulation	1.68604886
28	MP0003638_abnormal_response/metabolism_	1.63782495
29	MP0005083_abnormal_biliary_tract	1.63502178
30	MP0003950_abnormal_plasma_membrane	1.62053877
31	MP0005310_abnormal_salivary_gland	1.59095429
32	MP0004264_abnormal_extraembryonic_tissu	1.58875624
33	MP0003880_abnormal_central_pattern	1.56086434
34	MP0005377_hearing/vestibular/ear_phenot	1.53242237
35	MP0003878_abnormal_ear_physiology	1.53242237
36	MP0005397_hematopoietic_system_phenotyp	1.50043041
37	MP0001545_abnormal_hematopoietic_system	1.50043041
38	MP0009333_abnormal_splenocyte_physiolog	1.46826704
39	MP0001501_abnormal_sleep_pattern	1.38626358
40	MP0001881_abnormal_mammary_gland	1.31455217
41	MP0002796_impaired_skin_barrier	1.26396474
42	MP0006072_abnormal_retinal_apoptosis	1.25860522
43	MP0003959_abnormal_lean_body	1.25025640
44	MP0009046_muscle_twitch	1.24415180
45	MP0003786_premature_aging	1.20491871
46	MP0005451_abnormal_body_composition	1.20035069
47	MP0003191_abnormal_cellular_cholesterol	1.17945492
48	MP0000358_abnormal_cell_content/	1.16714547
49	MP0003646_muscle_fatigue	1.10045737
50	MP0003633_abnormal_nervous_system	1.05360457
51	MP0010771_integument_phenotype	1.03337936
52	MP0001664_abnormal_digestion	1.03014422
53	MP0002148_abnormal_hypersensitivity_rea	0.98750374
54	MP0010234_abnormal_vibrissa_follicle	0.97589334
55	MP0000465_gastrointestinal_hemorrhage	0.97311862
56	MP0005670_abnormal_white_adipose	0.92476372
57	MP0002108_abnormal_muscle_morphology	0.92354434
58	MP0005636_abnormal_mineral_homeostasis	0.86350131
59	MP0001765_abnormal_ion_homeostasis	0.85664899
60	MP0000749_muscle_degeneration	0.82665425
61	MP0005501_abnormal_skin_physiology	0.80851849
62	MP0008995_early_reproductive_senescence	0.80713683
63	MP0002693_abnormal_pancreas_physiology	0.80334895
64	MP0000647_abnormal_sebaceous_gland	0.80150598
65	MP0000627_abnormal_mammary_gland	0.79658394
66	MP0003936_abnormal_reproductive_system	0.78361118
67	MP0009765_abnormal_xenobiotic_induced	0.77815545
68	MP0001849_ear_inflammation	0.77254630
69	MP0002060_abnormal_skin_morphology	0.76941804
70	MP0005452_abnormal_adipose_tissue	0.75336733
71	MP0002168_other_aberrant_phenotype	0.73457246
72	MP0000230_abnormal_systemic_arterial	0.73173473
73	MP0008775_abnormal_heart_ventricle	0.69225126
74	MP0002557_abnormal_social/conspecific_i	0.68400982
75	MP0001873_stomach_inflammation	0.67336838
76	MP0001486_abnormal_startle_reflex	0.67264141
77	MP0010329_abnormal_lipoprotein_level	0.66298839
78	MP0003567_abnormal_fetal_cardiomyocyte	0.66028948
79	MP0001666_abnormal_nutrient_absorption	0.65639126
80	MP0009643_abnormal_urine_homeostasis	0.64448811
81	MP0002098_abnormal_vibrissa_morphology	0.63909722
82	MP0002229_neurodegeneration	0.63875563
83	MP0001963_abnormal_hearing_physiology	0.63300546
84	MP0005253_abnormal_eye_physiology	0.63240551
85	MP0001919_abnormal_reproductive_system	0.62998093
86	MP0002160_abnormal_reproductive_system	0.62760744
87	MP0002970_abnormal_white_adipose	0.62583854
88	MP0005085_abnormal_gallbladder_physiolo	0.62090823
89	MP0010155_abnormal_intestine_physiology	0.61426357
90	MP0003718_maternal_effect	0.60997762
91	MP0005332_abnormal_amino_acid	0.59489378
92	MP0001764_abnormal_homeostasis	0.58198632
93	MP0008058_abnormal_DNA_repair	0.56279986
94	MP0005395_other_phenotype	0.56062083
95	MP0003631_nervous_system_phenotype	0.55991166
96	MP0006036_abnormal_mitochondrial_physio	0.55480685
97	MP0002733_abnormal_thermal_nociception	0.53364760
98	MP0002090_abnormal_vision	0.53088547
99	MP0009745_abnormal_behavioral_response	0.53080996
100	MP0003938_abnormal_ear_development	0.52588405

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	9.84662972
2	Pancreatic islet-cell hyperplasia (HP:0004510)	5.98615607
3	Abnormality of endocrine pancreas physiology (HP:0012093)	5.49342225
4	Abnormality of the pancreatic islet cells (HP:0006476)	5.49342225
5	Volvulus (HP:0002580)	5.15049423
6	Congenital ichthyosiform erythroderma (HP:0007431)	4.52455304
7	Large for gestational age (HP:0001520)	4.50334709
8	Intestinal atresia (HP:0011100)	4.27179889
9	Abnormality of the aortic arch (HP:0012303)	4.14981426
10	Chronic hepatic failure (HP:0100626)	3.99554993
11	Mesangial abnormality (HP:0001966)	3.89267482
12	Abnormality of the ileum (HP:0001549)	3.89039615
13	Large eyes (HP:0001090)	3.83743567
14	11 pairs of ribs (HP:0000878)	3.68051571
15	Poor head control (HP:0002421)	3.59305129
16	Broad alveolar ridges (HP:0000187)	3.32352577
17	Oligodontia (HP:0000677)	3.23100400
18	Gaze-evoked nystagmus (HP:0000640)	3.03778614
19	Autoimmune hemolytic anemia (HP:0001890)	2.96693251
20	Agitation (HP:0000713)	2.96356724
21	Thickened helices (HP:0000391)	2.84967130
22	Keratoconus (HP:0000563)	2.79078975
23	Increased corneal curvature (HP:0100692)	2.79078975
24	Entropion (HP:0000621)	2.77686017
25	Hydroxyprolinuria (HP:0003080)	2.75317127
26	Abnormality of proline metabolism (HP:0010907)	2.75317127
27	Ectropion (HP:0000656)	2.72525714
28	Hypoproteinemia (HP:0003075)	2.70868911
29	Abnormal pupillary function (HP:0007686)	2.59632433
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.49232790
31	Tubular atrophy (HP:0000092)	2.47387797
32	Abnormal tarsal ossification (HP:0008369)	2.43832824
33	Cerebellar dysplasia (HP:0007033)	2.42111688
34	Attenuation of retinal blood vessels (HP:0007843)	2.42087893
35	Type II lissencephaly (HP:0007260)	2.35754296
36	Pendular nystagmus (HP:0012043)	2.32618904
37	Focal motor seizures (HP:0011153)	2.30839976
38	Poikiloderma (HP:0001029)	2.28130223
39	Orchitis (HP:0100796)	2.25786695
40	Myositis (HP:0100614)	2.22575260
41	Pili torti (HP:0003777)	2.22417517
42	Severe muscular hypotonia (HP:0006829)	2.19207443
43	Chromsome breakage (HP:0040012)	2.19082461
44	Abnormality of macular pigmentation (HP:0008002)	2.17934767
45	Areflexia of lower limbs (HP:0002522)	2.08175078
46	Abnormal foot bone ossification (HP:0010675)	2.06793181
47	Meckel diverticulum (HP:0002245)	2.06702762
48	Concave nail (HP:0001598)	2.06128118
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03752808
50	Carpal bone hypoplasia (HP:0001498)	2.03196868
51	Hypothermia (HP:0002045)	2.02589398
52	Tented upper lip vermilion (HP:0010804)	2.02103170
53	Optic nerve hypoplasia (HP:0000609)	2.01949374
54	Increased CSF lactate (HP:0002490)	2.01567470
55	Progressive inability to walk (HP:0002505)	1.96950948
56	Ketoacidosis (HP:0001993)	1.96852370
57	Severe visual impairment (HP:0001141)	1.96133591
58	Ileus (HP:0002595)	1.90954844
59	Acute encephalopathy (HP:0006846)	1.90735282
60	Epiphyseal stippling (HP:0010655)	1.89288768
61	Breast carcinoma (HP:0003002)	1.83602391
62	Nephroblastoma (Wilms tumor) (HP:0002667)	1.82673750
63	Abnormality of glycolysis (HP:0004366)	1.81674904
64	Hyporeflexia of lower limbs (HP:0002600)	1.80284833
65	Hypohidrosis (HP:0000966)	1.78894795
66	Keratitis (HP:0000491)	1.78253261
67	Hyperventilation (HP:0002883)	1.77208131
68	Flared iliac wings (HP:0002869)	1.76194040
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75891466
70	Gastrointestinal atresia (HP:0002589)	1.74598492
71	Abnormal hair laboratory examination (HP:0003328)	1.73744262
72	Abnormality of the alveolar ridges (HP:0006477)	1.73398192
73	Abnormal pancreas size (HP:0012094)	1.72332115
74	Abnormality of nail color (HP:0100643)	1.72112789
75	Broad-based gait (HP:0002136)	1.71813090
76	Chorioretinal atrophy (HP:0000533)	1.71341992
77	Pancreatic cysts (HP:0001737)	1.70698558
78	Hypoplasia of the odontoid process (HP:0003311)	1.70096469
79	Cone-rod dystrophy (HP:0000548)	1.68247738
80	Central scotoma (HP:0000603)	1.67172823
81	Congenital stationary night blindness (HP:0007642)	1.66836485
82	Curly hair (HP:0002212)	1.66279195
83	Embryonal renal neoplasm (HP:0011794)	1.65111412
84	Poor speech (HP:0002465)	1.64509233
85	Vascular calcification (HP:0004934)	1.63524727
86	Non-midline cleft lip (HP:0100335)	1.63191483
87	Late onset (HP:0003584)	1.63171557
88	Episodic fever (HP:0001954)	1.62847222
89	Lissencephaly (HP:0001339)	1.62349085
90	Neoplasm of the lung (HP:0100526)	1.61266399
91	Acute necrotizing encephalopathy (HP:0006965)	1.61048508
92	Amelogenesis imperfecta (HP:0000705)	1.60293651
93	Focal seizures (HP:0007359)	1.59107988
94	Small epiphyses (HP:0010585)	1.58143584
95	Selective tooth agenesis (HP:0001592)	1.58115156
96	Hyperlipoproteinemia (HP:0010980)	1.57864780
97	Goiter (HP:0000853)	1.56919055
98	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.56423014
99	Facial diplegia (HP:0001349)	1.56085245
100	Abnormal rod and cone electroretinograms (HP:0008323)	1.55815761

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	6.28691016
2	STK39	6.07481531
3	MST4	5.19085969
4	OXSR1	5.01899147
5	EIF2AK3	4.88920051
6	FRK	3.41729019
7	MAP3K12	3.19596980
8	ERN1	2.72152634
9	PINK1	2.50257366
10	ACVR1B	2.31010393
11	FER	2.11627013
12	ADRBK1	1.87282160
13	PRKCI	1.86513650
14	NEK1	1.67779199
15	PAK3	1.64655533
16	MST1R	1.54443999
17	IRAK3	1.51172969
18	STK10	1.30104645
19	GRK1	1.24763636
20	MAPKAPK3	1.24002391
21	VRK2	1.23826096
22	PRKCE	1.20857621
23	BMPR1B	1.15096311
24	PBK	1.15050829
25	TLK1	1.14895121
26	ZAK	1.13534768
27	CLK1	1.08879249
28	PDK2	1.05639030
29	EPHA2	0.96658179
30	MELK	0.96485484
31	FGFR1	0.91894861
32	IRAK1	0.91527956
33	BMX	0.90340262
34	MAP3K11	0.88910836
35	NME2	0.88181551
36	TGFBR1	0.85261482
37	MAP2K1	0.84203210
38	MAPK11	0.81728449
39	PRKCG	0.74372280
40	EIF2AK1	0.74056711
41	AKT2	0.71123070
42	MAPKAPK5	0.67106787
43	NME1	0.63506101
44	BCKDK	0.62296393
45	PHKG1	0.57655899
46	PHKG2	0.57655899
47	DAPK1	0.55358780
48	RPS6KB2	0.54072262
49	MAP3K5	0.52670771
50	WNK4	0.48102627
51	JAK1	0.46798126
52	PTK2	0.45286742
53	MET	0.42622444
54	BCR	0.40057790
55	CAMK2A	0.38382588
56	STK16	0.36670095
57	MYLK	0.36586987
58	PNCK	0.35535149
59	INSRR	0.35171791
60	ATR	0.33544333
61	EIF2AK2	0.32462877
62	PLK2	0.31483034
63	ABL1	0.30060922
64	VRK1	0.29814493
65	STK38L	0.29564850
66	PTK2B	0.29528382
67	CHUK	0.28868169
68	GRK5	0.28632682
69	LRRK2	0.27538558
70	AKT3	0.27506099
71	AURKA	0.26355325
72	STK38	0.25302341
73	BUB1	0.24702174
74	CAMK4	0.24057571
75	EEF2K	0.20987903
76	MAP2K6	0.20926078
77	ERBB2	0.20556139
78	PAK1	0.20433396
79	MAP3K8	0.19429983
80	CSNK2A2	0.18536895
81	CSNK1A1L	0.17523334
82	TYRO3	0.17473960
83	IKBKE	0.16645998
84	IKBKB	0.15440196
85	SGK1	0.15172462
86	TNK2	0.14946811
87	TRPM7	0.14728535
88	EPHA3	0.14719701
89	TIE1	0.14391414
90	LMTK2	0.14354385
91	IGF1R	0.13862129
92	AKT1	0.13847907
93	SGK2	0.13637163
94	RPS6KB1	0.11940047
95	STK3	0.11300405
96	CSNK1A1	0.10315219
97	PRKCA	0.10065506
98	CSNK1G3	0.10050094
99	LIMK1	0.09197030
100	DYRK3	0.06879201

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.66676814
2	Proteasome_Homo sapiens_hsa03050	3.21867006
3	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.78292139
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.48267048
5	Caffeine metabolism_Homo sapiens_hsa00232	2.39671716
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.29670616
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.23718868
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06436950
9	Sulfur relay system_Homo sapiens_hsa04122	2.02400581
10	Glutathione metabolism_Homo sapiens_hsa00480	1.97778437
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97626605
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.96229300
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.93679301
14	Butanoate metabolism_Homo sapiens_hsa00650	1.91875818
15	Phototransduction_Homo sapiens_hsa04744	1.85497724
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.84225535
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.81362636
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81041931
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.78726811
20	Peroxisome_Homo sapiens_hsa04146	1.76308522
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.76190920
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.75096453
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70326611
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.68509945
25	Homologous recombination_Homo sapiens_hsa03440	1.63623783
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.61188263
27	ABC transporters_Homo sapiens_hsa02010	1.58681756
28	RNA polymerase_Homo sapiens_hsa03020	1.54059925
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.50292536
30	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.46163145
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.41821838
32	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.34950700
33	Parkinsons disease_Homo sapiens_hsa05012	1.31494733
34	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.30999996
35	Retinol metabolism_Homo sapiens_hsa00830	1.30805163
36	Folate biosynthesis_Homo sapiens_hsa00790	1.29605192
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.28034805
38	Propanoate metabolism_Homo sapiens_hsa00640	1.26497850
39	Protein export_Homo sapiens_hsa03060	1.26150206
40	Pentose phosphate pathway_Homo sapiens_hsa00030	1.25093601
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.18593566
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16895116
43	Mineral absorption_Homo sapiens_hsa04978	1.14983424
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.13683131
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13066643
46	Olfactory transduction_Homo sapiens_hsa04740	1.12502357
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.11076591
48	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10031855
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08482875
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07481881
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06675692
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06621536
53	Arginine biosynthesis_Homo sapiens_hsa00220	1.05767648
54	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05265040
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02362907
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.01126217
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.99900180
58	Huntingtons disease_Homo sapiens_hsa05016	0.99522318
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.99366618
60	Fatty acid elongation_Homo sapiens_hsa00062	0.98534701
61	Metabolic pathways_Homo sapiens_hsa01100	0.94812355
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94798618
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.91538154
64	DNA replication_Homo sapiens_hsa03030	0.90580481
65	Alzheimers disease_Homo sapiens_hsa05010	0.88551954
66	Sulfur metabolism_Homo sapiens_hsa00920	0.87989729
67	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.86741410
68	Fatty acid degradation_Homo sapiens_hsa00071	0.86309928
69	Pancreatic secretion_Homo sapiens_hsa04972	0.86021603
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83911702
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83171128
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.79958677
73	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.78877069
74	Complement and coagulation cascades_Homo sapiens_hsa04610	0.74725266
75	One carbon pool by folate_Homo sapiens_hsa00670	0.64078660
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.62936582
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.62660074
78	Purine metabolism_Homo sapiens_hsa00230	0.61930906
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57299884
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57275640
81	Base excision repair_Homo sapiens_hsa03410	0.56048459
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47632574
83	Salivary secretion_Homo sapiens_hsa04970	0.47077664
84	Lysosome_Homo sapiens_hsa04142	0.45798800
85	RNA degradation_Homo sapiens_hsa03018	0.45627496
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40405452
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40266916
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39906133
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37280867
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36927622
91	Morphine addiction_Homo sapiens_hsa05032	0.36219753
92	Vibrio cholerae infection_Homo sapiens_hsa05110	0.35858704
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35139443
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.34145702
95	RNA transport_Homo sapiens_hsa03013	0.33334795
96	p53 signaling pathway_Homo sapiens_hsa04115	0.33133269
97	Carbon metabolism_Homo sapiens_hsa01200	0.31243455
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.30512493
99	Taste transduction_Homo sapiens_hsa04742	0.27649143
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.26950424

KRT8P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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