ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	bundle of His cell to Purkinje myocyte communication (GO:0086069)	9.84821955
2	icosanoid biosynthetic process (GO:0046456)	8.95752939
3	fatty acid derivative biosynthetic process (GO:1901570)	8.95752939
4	glutathione metabolic process (GO:0006749)	8.02606447
5	cysteine metabolic process (GO:0006534)	7.46319047
6	unsaturated fatty acid biosynthetic process (GO:0006636)	7.34844886
7	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	6.84261374
8	mitochondrial calcium ion transport (GO:0006851)	5.70141323
9	icosanoid metabolic process (GO:0006690)	5.36633921
10	fatty acid derivative metabolic process (GO:1901568)	5.36633921
11	polyketide metabolic process (GO:0030638)	5.11174908
12	doxorubicin metabolic process (GO:0044598)	5.11174908
13	daunorubicin metabolic process (GO:0044597)	5.11174908
14	peptide catabolic process (GO:0043171)	5.06158245
15	unsaturated fatty acid metabolic process (GO:0033559)	4.85103410
16	serine family amino acid biosynthetic process (GO:0009070)	4.60223945
17	artery smooth muscle contraction (GO:0014824)	4.58496449
18	aminoglycoside antibiotic metabolic process (GO:0030647)	4.52974127
19	mitochondrion distribution (GO:0048311)	4.51765935
20	glutathione derivative biosynthetic process (GO:1901687)	4.29773034
21	glutathione derivative metabolic process (GO:1901685)	4.29773034
22	hepatocyte apoptotic process (GO:0097284)	4.26153936
23	xenobiotic catabolic process (GO:0042178)	4.21179702
24	glutathione biosynthetic process (GO:0006750)	4.17516247
25	peptide metabolic process (GO:0006518)	4.01785352
26	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.83862847
27	androgen biosynthetic process (GO:0006702)	3.80277263
28	glutamate metabolic process (GO:0006536)	3.76817261
29	tonic smooth muscle contraction (GO:0014820)	3.74602166
30	nonribosomal peptide biosynthetic process (GO:0019184)	3.69294011
31	NADH metabolic process (GO:0006734)	3.65812548
32	regulation of bile acid biosynthetic process (GO:0070857)	3.61420342
33	fatty acid biosynthetic process (GO:0006633)	3.60219153
34	regulation of triglyceride catabolic process (GO:0010896)	3.57217884
35	GTP biosynthetic process (GO:0006183)	3.51118140
36	prostanoid metabolic process (GO:0006692)	3.45772340
37	prostaglandin metabolic process (GO:0006693)	3.45772340
38	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.43294736
39	inositol phosphate-mediated signaling (GO:0048016)	3.42389452
40	energy homeostasis (GO:0097009)	3.39517779
41	primary alcohol catabolic process (GO:0034310)	3.38641600
42	cellular modified amino acid catabolic process (GO:0042219)	3.37823099
43	desmosome organization (GO:0002934)	3.36706671
44	UTP biosynthetic process (GO:0006228)	3.35972165
45	vitamin transmembrane transport (GO:0035461)	3.27363037
46	macroautophagy (GO:0016236)	3.26754698
47	glycoside metabolic process (GO:0016137)	3.18814129
48	prostanoid biosynthetic process (GO:0046457)	3.16783168
49	prostaglandin biosynthetic process (GO:0001516)	3.16783168
50	ketone biosynthetic process (GO:0042181)	3.16407176
51	regulation of oxidative phosphorylation (GO:0002082)	3.16238463
52	sulfur amino acid biosynthetic process (GO:0000097)	3.10313510
53	auditory receptor cell differentiation (GO:0042491)	3.09433455
54	L-phenylalanine metabolic process (GO:0006558)	3.06975880
55	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.06975880
56	UTP metabolic process (GO:0046051)	3.06570279
57	detection of molecule of bacterial origin (GO:0032490)	3.03447242
58	hair cell differentiation (GO:0035315)	3.02925044
59	nucleotide-sugar biosynthetic process (GO:0009226)	3.01201143
60	cellular amide metabolic process (GO:0043603)	3.01094751
61	epoxygenase P450 pathway (GO:0019373)	2.99232276
62	negative regulation of hormone metabolic process (GO:0032351)	2.97174129
63	cobalamin metabolic process (GO:0009235)	2.95959174
64	peptide biosynthetic process (GO:0043043)	2.93779999
65	flavonoid metabolic process (GO:0009812)	2.90705766
66	guanosine-containing compound biosynthetic process (GO:1901070)	2.89555180
67	urate metabolic process (GO:0046415)	2.88831472
68	drug transport (GO:0015893)	2.87474878
69	viral mRNA export from host cell nucleus (GO:0046784)	2.87035022
70	dicarboxylic acid biosynthetic process (GO:0043650)	2.86865227
71	digestion (GO:0007586)	2.82682160
72	intestinal absorption (GO:0050892)	2.80562955
73	phasic smooth muscle contraction (GO:0014821)	2.80468126
74	regulation of guanylate cyclase activity (GO:0031282)	2.80411267
75	phenylpropanoid metabolic process (GO:0009698)	2.73631233
76	L-alpha-amino acid transmembrane transport (GO:1902475)	2.71913592
77	serine family amino acid metabolic process (GO:0009069)	2.71838503
78	macrophage activation (GO:0042116)	2.70857924
79	L-ascorbic acid metabolic process (GO:0019852)	2.67745657
80	quinone metabolic process (GO:1901661)	2.66852161
81	COPI coating of Golgi vesicle (GO:0048205)	2.65871215
82	Golgi transport vesicle coating (GO:0048200)	2.65871215
83	intestinal epithelial cell development (GO:0060576)	2.64869204
84	glutamine family amino acid biosynthetic process (GO:0009084)	2.61927347
85	GDP-mannose metabolic process (GO:0019673)	2.59130347
86	cyclooxygenase pathway (GO:0019371)	2.58736140
87	peroxisome fission (GO:0016559)	2.57362478
88	urea cycle (GO:0000050)	2.57327825
89	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.56815463
90	CTP metabolic process (GO:0046036)	2.56147960
91	CTP biosynthetic process (GO:0006241)	2.56147960
92	glycolipid catabolic process (GO:0019377)	2.56134772
93	mitochondrial RNA metabolic process (GO:0000959)	2.56133596
94	drug transmembrane transport (GO:0006855)	2.50937118
95	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.50869250
96	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.50485321
97	toxin transport (GO:1901998)	2.50404097
98	glucuronate metabolic process (GO:0019585)	2.49017869
99	leukotriene biosynthetic process (GO:0019370)	14.1850092
100	leukotriene metabolic process (GO:0006691)	10.0104417

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.49318664
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.16643895
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.04037237
4	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.67218097
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.36943768
6	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	3.29833848
7	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.20896652
8	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.01390542
9	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.75229956
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.68371652
11	VDR_22108803_ChIP-Seq_LS180_Human	2.54166709
12	GATA6_25053715_ChIP-Seq_YYC3_Human	2.45191047
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.41053435
14	GATA4_25053715_ChIP-Seq_YYC3_Human	2.33111816
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.20219625
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.96131605
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91947250
18	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.87455695
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85525975
20	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.81583809
21	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.73996498
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72674029
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.71598238
24	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.68358327
25	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.64617469
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62798585
27	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.59057329
28	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.58892693
29	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.56856351
30	ZNF263_19887448_ChIP-Seq_K562_Human	1.54684221
31	SOX2_20726797_ChIP-Seq_SW620_Human	1.50536042
32	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.48785399
33	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.47160111
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.47157057
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.44528580
36	CDX2_22108803_ChIP-Seq_LS180_Human	1.42504111
37	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.40099889
38	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.39533427
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32832497
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32506134
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.30863781
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.28565904
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28144701
44	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.27730147
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27513407
46	AR_20517297_ChIP-Seq_VCAP_Human	1.25589684
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25554491
48	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.24989505
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24519777
50	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.24426442
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24362639
52	AR_21909140_ChIP-Seq_LNCAP_Human	1.22311278
53	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.21884755
54	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.21884755
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.20022009
56	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19554107
57	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.17636955
58	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.15720966
59	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12978692
60	STAT1_20625510_ChIP-Seq_HELA_Human	1.08646743
61	KDM5A_27292631_Chip-Seq_BREAST_Human	1.08267905
62	GABP_19822575_ChIP-Seq_HepG2_Human	1.05857877
63	KLF5_25053715_ChIP-Seq_YYC3_Human	1.04447606
64	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.03193913
65	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02078887
66	ATF3_27146783_Chip-Seq_COLON_Human	1.01716303
67	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.00648942
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99559493
69	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.99107146
70	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.98601420
71	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.97005491
72	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.94851461
73	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.93843504
74	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.93495045
75	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.92623297
76	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91578389
77	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.91380302
78	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.90043730
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89269441
80	CBP_20019798_ChIP-Seq_JUKART_Human	0.88291674
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88291674
82	TP53_22573176_ChIP-Seq_HFKS_Human	0.86561140
83	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.85902381
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.85808486
85	OCT4_20526341_ChIP-Seq_ESCs_Human	0.85293966
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84401771
87	NCOR_22424771_ChIP-Seq_293T_Human	0.84029642
88	PHF8_20622853_ChIP-Seq_HELA_Human	0.81798395
89	ELF5_23300383_ChIP-Seq_T47D_Human	0.81027011
90	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.80989045
91	PHF8_20622854_ChIP-Seq_HELA_Human	0.80151605
92	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.79790979
93	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.78936241
94	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.78375946
95	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.77313209
96	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.77125146
97	CEBPB_22108803_ChIP-Seq_LS180_Human	0.76836722
98	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.76159494
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.75661501
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.75661501

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	5.85072824
2	MP0005360_urolithiasis	4.46557458
3	MP0010234_abnormal_vibrissa_follicle	4.08272574
4	MP0005379_endocrine/exocrine_gland_phen	3.98945691
5	MP0003183_abnormal_peptide_metabolism	3.98902963
6	MP0000613_abnormal_salivary_gland	3.71120193
7	MP0002736_abnormal_nociception_after	3.22270802
8	MP0002139_abnormal_hepatobiliary_system	3.13753013
9	MP0001666_abnormal_nutrient_absorption	3.08199853
10	MP0003195_calcinosis	3.02287632
11	MP0005365_abnormal_bile_salt	2.80823458
12	MP0005220_abnormal_exocrine_pancreas	2.80334102
13	MP0003693_abnormal_embryo_hatching	2.79094496
14	MP0004019_abnormal_vitamin_homeostasis	2.73206551
15	MP0005085_abnormal_gallbladder_physiolo	2.49189726
16	MP0002822_catalepsy	2.42861272
17	MP0005451_abnormal_body_composition	2.40869238
18	MP0008875_abnormal_xenobiotic_pharmacok	2.36851986
19	MP0003806_abnormal_nucleotide_metabolis	2.32134933
20	MP0004264_abnormal_extraembryonic_tissu	2.12258183
21	MP0002089_abnormal_postnatal_growth/wei	2.10725765
22	MP0010352_gastrointestinal_tract_polyps	2.01873766
23	MP0005332_abnormal_amino_acid	1.92224609
24	MP0001968_abnormal_touch/_nociception	1.88401195
25	MP0003252_abnormal_bile_duct	1.69907450
26	MP0002132_abnormal_respiratory_system	1.66021449
27	MP0003868_abnormal_feces_composition	1.65723800
28	MP0010678_abnormal_skin_adnexa	1.51716835
29	MP0008872_abnormal_physiological_respon	1.51353545
30	MP0001764_abnormal_homeostasis	1.50486045
31	MP0002277_abnormal_respiratory_mucosa	1.47310536
32	MP0004957_abnormal_blastocyst_morpholog	1.44774238
33	MP0008260_abnormal_autophagy	1.43376741
34	MP0000647_abnormal_sebaceous_gland	1.40164633
35	MP0003786_premature_aging	1.34155643
36	MP0002138_abnormal_hepatobiliary_system	1.30727015
37	MP0001765_abnormal_ion_homeostasis	1.30534817
38	MP0000013_abnormal_adipose_tissue	1.28913836
39	MP0005319_abnormal_enzyme/_coenzyme	1.25501813
40	MP0000858_altered_metastatic_potential	1.24128739
41	MP0005084_abnormal_gallbladder_morpholo	1.20418482
42	MP0010329_abnormal_lipoprotein_level	1.19393694
43	MP0002877_abnormal_melanocyte_morpholog	1.18951312
44	MP0005408_hypopigmentation	1.18793269
45	MP0004147_increased_porphyrin_level	1.17026248
46	MP0009643_abnormal_urine_homeostasis	1.15607784
47	MP0005636_abnormal_mineral_homeostasis	1.14102537
48	MP0000383_abnormal_hair_follicle	1.13027715
49	MP0005584_abnormal_enzyme/coenzyme_acti	1.12596861
50	MP0001756_abnormal_urination	1.12198653
51	MP0002796_impaired_skin_barrier	1.11954417
52	MP0010386_abnormal_urinary_bladder	1.09716445
53	MP0000462_abnormal_digestive_system	1.08196716
54	MP0003191_abnormal_cellular_cholesterol	1.01131811
55	MP0000538_abnormal_urinary_bladder	1.00525636
56	MP0000015_abnormal_ear_pigmentation	1.00098501
57	MP0001944_abnormal_pancreas_morphology	0.97012262
58	MP0000371_diluted_coat_color	0.92671701
59	MP0000470_abnormal_stomach_morphology	0.92501464
60	MP0010771_integument_phenotype	0.91520574
61	MP0003959_abnormal_lean_body	0.89820612
62	MP0001873_stomach_inflammation	0.88438006
63	MP0002118_abnormal_lipid_homeostasis	0.88057314
64	MP0005248_abnormal_Harderian_gland	0.83502474
65	MP0006035_abnormal_mitochondrial_morpho	0.80949428
66	MP0002876_abnormal_thyroid_physiology	0.79071408
67	MP0006082_CNS_inflammation	0.78947613
68	MP0002909_abnormal_adrenal_gland	0.78435539
69	MP0000609_abnormal_liver_physiology	0.77763307
70	MP0001664_abnormal_digestion	0.77502802
71	MP0008995_early_reproductive_senescence	0.76989150
72	MP0005058_abnormal_lysosome_morphology	0.75624802
73	MP0000598_abnormal_liver_morphology	0.74286623
74	MP0005501_abnormal_skin_physiology	0.74011203
75	MP0002098_abnormal_vibrissa_morphology	0.73250603
76	MP0006054_spinal_hemorrhage	0.71146037
77	MP0001663_abnormal_digestive_system	0.69682826
78	MP0009379_abnormal_foot_pigmentation	0.69640579
79	MP0005166_decreased_susceptibility_to	0.68936108
80	MP0000358_abnormal_cell_content/	0.67892829
81	MP0000367_abnormal_coat/_hair	0.67136933
82	MP0003718_maternal_effect	0.65419469
83	MP0005083_abnormal_biliary_tract	0.62985635
84	MP0009840_abnormal_foam_cell	0.62916032
85	MP0003953_abnormal_hormone_level	0.62524520
86	MP0001216_abnormal_epidermal_layer	0.62379210
87	MP0000537_abnormal_urethra_morphology	0.62175933
88	MP0005409_darkened_coat_color	0.60468868
89	MP0009780_abnormal_chondrocyte_physiolo	0.58585380
90	MP0002693_abnormal_pancreas_physiology	0.58581298
91	MP0002078_abnormal_glucose_homeostasis	0.58363196
92	MP0002136_abnormal_kidney_physiology	0.57722470
93	MP0003172_abnormal_lysosome_physiology	0.56748099
94	MP0004484_altered_response_of	0.56687028
95	MP0005647_abnormal_sex_gland	0.56025026
96	MP0009642_abnormal_blood_homeostasis	0.54369804
97	MP0005381_digestive/alimentary_phenotyp	0.53712542
98	MP0000477_abnormal_intestine_morphology	0.52859541
99	MP0005448_abnormal_energy_balance	0.52155714
100	MP0000569_abnormal_digit_pigmentation	0.52072868

Predicted human phenotypes

Rank	Gene Set	Z-score
1	J-shaped sella turcica (HP:0002680)	5.77961223
2	Abnormality of liposaccharide metabolism (HP:0010968)	4.42088328
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.42088328
4	Abnormality of glycolipid metabolism (HP:0010969)	4.42088328
5	Tongue fasciculations (HP:0001308)	4.21414055
6	Malnutrition (HP:0004395)	4.08577025
7	Vascular calcification (HP:0004934)	4.01895016
8	Vertebral arch anomaly (HP:0008438)	3.82256220
9	Muscle fibrillation (HP:0010546)	3.75264029
10	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.64462408
11	Thoracolumbar scoliosis (HP:0002944)	3.42257848
12	Steatorrhea (HP:0002570)	3.39386653
13	Cardiovascular calcification (HP:0011915)	3.30812440
14	Nausea (HP:0002018)	3.28418039
15	Fat malabsorption (HP:0002630)	3.22317655
16	Proximal tubulopathy (HP:0000114)	3.17873612
17	Carpal bone hypoplasia (HP:0001498)	3.11549185
18	Hypobetalipoproteinemia (HP:0003563)	3.03252175
19	Hypoglycemic coma (HP:0001325)	3.01953777
20	Symptomatic seizures (HP:0011145)	2.85892971
21	Hydroxyprolinuria (HP:0003080)	2.84152815
22	Abnormality of proline metabolism (HP:0010907)	2.84152815
23	Hypomagnesemia (HP:0002917)	2.83233980
24	Abnormality of magnesium homeostasis (HP:0004921)	2.77090420
25	Deformed sella turcica (HP:0002681)	2.74512189
26	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.73320409
27	Abnormality of polysaccharide metabolism (HP:0011012)	2.73320409
28	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.73320409
29	Hypoglycemic seizures (HP:0002173)	2.71501117
30	Mucopolysacchariduria (HP:0008155)	2.69977691
31	Urinary glycosaminoglycan excretion (HP:0003541)	2.69977691
32	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.67270406
33	Congenital sensorineural hearing impairment (HP:0008527)	2.65734720
34	Ketoacidosis (HP:0001993)	2.62565361
35	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.59381651
36	Diastasis recti (HP:0001540)	2.59096873
37	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.55917152
38	Micronodular cirrhosis (HP:0001413)	2.55253476
39	Abnormality of methionine metabolism (HP:0010901)	2.54881243
40	Abdominal distention (HP:0003270)	2.54064421
41	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.53011467
42	Ileus (HP:0002595)	2.51424379
43	Flat acetabular roof (HP:0003180)	2.49508942
44	Unilateral renal agenesis (HP:0000122)	2.47989611
45	Tetraparesis (HP:0002273)	2.44454990
46	Beaking of vertebral bodies (HP:0004568)	2.40814879
47	Prolonged partial thromboplastin time (HP:0003645)	2.40462727
48	Hyperglycemia (HP:0003074)	2.39870991
49	Intrahepatic cholestasis (HP:0001406)	2.38720887
50	Hyperammonemia (HP:0001987)	2.38152890
51	Protuberant abdomen (HP:0001538)	2.34451208
52	Hyperinsulinemic hypoglycemia (HP:0000825)	2.33526273
53	Renal tubular acidosis (HP:0001947)	2.28103626
54	Congenital ichthyosiform erythroderma (HP:0007431)	2.28060560
55	Abnormality of the sella turcica (HP:0002679)	2.14326163
56	Vacuolated lymphocytes (HP:0001922)	2.13990806
57	Lethargy (HP:0001254)	2.10753241
58	Hypokinesia (HP:0002375)	2.10076085
59	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.09357082
60	Cardiomegaly (HP:0001640)	2.08979689
61	Abnormality of urine glucose concentration (HP:0011016)	2.06602008
62	Glycosuria (HP:0003076)	2.06602008
63	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.06393435
64	Hypoplastic scapulae (HP:0000882)	2.06393435
65	Amelogenesis imperfecta (HP:0000705)	2.00573060
66	Abnormal pancreas size (HP:0012094)	1.99384485
67	Type I transferrin isoform profile (HP:0003642)	1.97945696
68	Flared iliac wings (HP:0002869)	1.97178864
69	Hyperphosphatemia (HP:0002905)	1.94158259
70	Dicarboxylic aciduria (HP:0003215)	1.93748791
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.93748791
72	Right ventricular cardiomyopathy (HP:0011663)	1.93418483
73	Lipid accumulation in hepatocytes (HP:0006561)	1.93155267
74	Hypolipoproteinemia (HP:0010981)	1.92692541
75	Ketosis (HP:0001946)	1.92568925
76	Broad alveolar ridges (HP:0000187)	1.91805750
77	Secondary amenorrhea (HP:0000869)	1.90877775
78	Absent/shortened dynein arms (HP:0200106)	1.89753471
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89753471
80	Pathologic fracture (HP:0002756)	1.89402932
81	Thoracic kyphosis (HP:0002942)	1.84323989
82	Wide intermamillary distance (HP:0006610)	1.83740983
83	Death in childhood (HP:0003819)	1.81259009
84	Metabolic acidosis (HP:0001942)	1.81114246
85	Reduced antithrombin III activity (HP:0001976)	1.79419995
86	Tetany (HP:0001281)	1.77257143
87	Abnormality of small intestinal villus morphology (HP:0011472)	1.75518271
88	Villous atrophy (HP:0011473)	1.75518271
89	Prominent metopic ridge (HP:0005487)	1.75019051
90	Abnormality of the lumbar spine (HP:0100712)	1.73955821
91	Cone-rod dystrophy (HP:0000548)	1.73862453
92	Renal tubular dysfunction (HP:0000124)	1.72887393
93	Late onset (HP:0003584)	1.72338667
94	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.72076634
95	Abnormality of the pancreatic islet cells (HP:0006476)	1.71460951
96	Abnormality of endocrine pancreas physiology (HP:0012093)	1.71460951
97	Paraparesis (HP:0002385)	1.71377700
98	Palpebral edema (HP:0100540)	1.70602050
99	Gingival bleeding (HP:0000225)	1.68883637
100	Prolonged neonatal jaundice (HP:0006579)	1.68045190

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	5.18449414
2	EPHA2	5.07988812
3	TLK1	4.99565236
4	FRK	3.76575210
5	PDK2	3.69604205
6	LMTK2	3.39853538
7	MST4	3.03128639
8	MST1R	2.76988920
9	ZAK	2.71294216
10	BUB1	2.29520100
11	PBK	2.12030933
12	STK16	2.02815130
13	MAP3K12	2.02302389
14	MAP3K2	1.99948405
15	STK39	1.92063260
16	RPS6KB2	1.65028145
17	MAP3K3	1.54584868
18	MET	1.50605406
19	NEK1	1.46614597
20	STK4	1.46589564
21	OXSR1	1.32339427
22	SCYL2	1.29282227
23	NUAK1	1.24537287
24	VRK2	1.21013000
25	TNIK	1.19902716
26	GRK6	1.17489192
27	GRK5	1.16352030
28	STK10	1.09550059
29	EIF2AK1	1.08381752
30	VRK1	1.06368808
31	TAOK1	0.99263127
32	ERN1	0.98645329
33	STK24	0.97178191
34	CSNK1A1L	0.95253821
35	RPS6KA5	0.94821959
36	NME1	0.93864212
37	TESK1	0.88589881
38	EIF2AK3	0.87107557
39	TAOK3	0.82654567
40	GRK1	0.81936593
41	PAK4	0.81173028
42	PRKG2	0.80052962
43	CHUK	0.79861507
44	MAP2K2	0.78466743
45	MAP3K1	0.77582665
46	STK38L	0.77539338
47	PIK3CG	0.75628350
48	CSNK1G3	0.74550023
49	FER	0.72071309
50	TRIM28	0.71601531
51	DAPK3	0.71507235
52	PTK6	0.70416370
53	IKBKB	0.69651920
54	MAP2K6	0.69019055
55	CAMK4	0.65580109
56	TSSK6	0.64901736
57	CAMK2D	0.63457139
58	CDK3	0.63404276
59	GRK7	0.63051732
60	AURKB	0.62277669
61	MELK	0.60799024
62	MAP3K11	0.59351407
63	MAP3K13	0.59116119
64	CAMK2G	0.58759317
65	ACVR1B	0.57302078
66	NME2	0.55771849
67	AURKA	0.55174234
68	WNK4	0.54956609
69	TGFBR2	0.54667733
70	RPS6KA4	0.54156656
71	AKT2	0.52288084
72	TBK1	0.49963557
73	MAP3K8	0.47470211
74	ERBB2	0.46058114
75	MAP3K9	0.45670378
76	IKBKE	0.45669372
77	DAPK1	0.45394316
78	PIM1	0.45065772
79	FGR	0.44695347
80	DAPK2	0.44206732
81	BCKDK	0.44097692
82	PRKCE	0.43854436
83	CSNK1G1	0.42529560
84	MAP2K3	0.40923642
85	CAMK2B	0.40376877
86	CDK9	0.40192488
87	NEK6	0.38471780
88	TAF1	0.37778540
89	PIK3CA	0.37155096
90	MAP2K1	0.36843695
91	PRKCI	0.36673938
92	CSNK1A1	0.35287830
93	PTK2B	0.35280344
94	PLK1	0.35109403
95	EIF2AK2	0.34366190
96	ILK	0.31996486
97	SMG1	0.31021835
98	ADRBK2	0.29883070
99	EGFR	0.27799706
100	MATK	0.26362369

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	7.60904071
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.84589279
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.39401783
4	Glutathione metabolism_Homo sapiens_hsa00480	2.47678972
5	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.35453460
6	Fat digestion and absorption_Homo sapiens_hsa04975	2.24081214
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.00682543
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.00240446
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.97238975
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.96263837
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.92574203
12	Proteasome_Homo sapiens_hsa03050	1.82431857
13	Sulfur metabolism_Homo sapiens_hsa00920	1.74093970
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.65016902
15	Fatty acid degradation_Homo sapiens_hsa00071	1.62978347
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62448677
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.52804338
18	Fatty acid elongation_Homo sapiens_hsa00062	1.51210440
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.48426857
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.47267242
21	Pancreatic secretion_Homo sapiens_hsa04972	1.46587043
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.44484095
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.44007611
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.42002057
25	Vibrio cholerae infection_Homo sapiens_hsa05110	1.32186202
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30257935
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27494422
28	Folate biosynthesis_Homo sapiens_hsa00790	1.24744953
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.23524283
30	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.22986283
31	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.22501533
32	Histidine metabolism_Homo sapiens_hsa00340	1.22147405
33	Alcoholism_Homo sapiens_hsa05034	1.20357671
34	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.18749180
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.17279387
36	Protein digestion and absorption_Homo sapiens_hsa04974	1.16323003
37	Renin-angiotensin system_Homo sapiens_hsa04614	1.14137061
38	Peroxisome_Homo sapiens_hsa04146	1.10340711
39	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.09492003
40	Pentose phosphate pathway_Homo sapiens_hsa00030	1.08019025
41	Galactose metabolism_Homo sapiens_hsa00052	1.07624600
42	Glycerolipid metabolism_Homo sapiens_hsa00561	1.04877508
43	Sulfur relay system_Homo sapiens_hsa04122	1.04141958
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.00446278
45	Retinol metabolism_Homo sapiens_hsa00830	1.00154623
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.98612056
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98263400
48	Carbon metabolism_Homo sapiens_hsa01200	0.97376341
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.96986748
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.96597573
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95645634
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95081874
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.91686700
54	Bile secretion_Homo sapiens_hsa04976	0.91432068
55	Caffeine metabolism_Homo sapiens_hsa00232	0.90668355
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.88200825
57	Butanoate metabolism_Homo sapiens_hsa00650	0.84249473
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81693424
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81682410
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81390243
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.79764986
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.77657356
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76841462
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74084858
65	Phenylalanine metabolism_Homo sapiens_hsa00360	0.72723283
66	Mineral absorption_Homo sapiens_hsa04978	0.68083496
67	Metabolic pathways_Homo sapiens_hsa01100	0.64949392
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64401321
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58801390
70	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56873663
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56498606
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.56479162
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56005787
74	PPAR signaling pathway_Homo sapiens_hsa03320	0.53889574
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52546292
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51644118
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50878306
78	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50193297
79	Lysosome_Homo sapiens_hsa04142	0.48097375
80	Other glycan degradation_Homo sapiens_hsa00511	0.47403657
81	Parkinsons disease_Homo sapiens_hsa05012	0.41438538
82	Viral carcinogenesis_Homo sapiens_hsa05203	0.41320238
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.40821145
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39236099
85	One carbon pool by folate_Homo sapiens_hsa00670	0.38646874
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.37396051
87	Huntingtons disease_Homo sapiens_hsa05016	0.36416857
88	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.36081299
89	Propanoate metabolism_Homo sapiens_hsa00640	0.35835459
90	Thyroid cancer_Homo sapiens_hsa05216	0.33564728
91	Purine metabolism_Homo sapiens_hsa00230	0.33329099
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29261387
93	ABC transporters_Homo sapiens_hsa02010	0.28617636
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.28492431
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.27554862
96	Tight junction_Homo sapiens_hsa04530	0.27385182
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27096649
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.24022481
99	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.21723171
100	RNA transport_Homo sapiens_hsa03013	0.21650205

KRT8P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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