ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene biosynthetic process (GO:0019370)	8.62126710
2	cysteine metabolic process (GO:0006534)	7.49591105
3	fatty acid derivative biosynthetic process (GO:1901570)	5.98757427
4	icosanoid biosynthetic process (GO:0046456)	5.98757427
5	leukotriene metabolic process (GO:0006691)	5.83778510
6	glutathione metabolic process (GO:0006749)	5.41419983
7	unsaturated fatty acid biosynthetic process (GO:0006636)	4.96992120
8	peptide catabolic process (GO:0043171)	4.69505924
9	glutathione derivative metabolic process (GO:1901685)	4.31668919
10	glutathione derivative biosynthetic process (GO:1901687)	4.31668919
11	glutathione biosynthetic process (GO:0006750)	4.30310662
12	xenobiotic catabolic process (GO:0042178)	4.26345022
13	artery smooth muscle contraction (GO:0014824)	4.19535869
14	response to nitrosative stress (GO:0051409)	4.07059117
15	somite rostral/caudal axis specification (GO:0032525)	4.06359573
16	nonribosomal peptide biosynthetic process (GO:0019184)	4.03475098
17	proteasome assembly (GO:0043248)	3.80686554
18	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.78257073
19	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.78257073
20	prostaglandin biosynthetic process (GO:0001516)	3.75701392
21	prostanoid biosynthetic process (GO:0046457)	3.75701392
22	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.64865690
23	icosanoid metabolic process (GO:0006690)	3.61882893
24	fatty acid derivative metabolic process (GO:1901568)	3.61882893
25	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.60828727
26	tonic smooth muscle contraction (GO:0014820)	3.56691349
27	endosome to pigment granule transport (GO:0043485)	3.54349596
28	endosome to melanosome transport (GO:0035646)	3.54349596
29	copper ion homeostasis (GO:0055070)	3.51641726
30	cobalamin metabolic process (GO:0009235)	3.47021503
31	daunorubicin metabolic process (GO:0044597)	3.44641892
32	polyketide metabolic process (GO:0030638)	3.44641892
33	doxorubicin metabolic process (GO:0044598)	3.44641892
34	nucleotide transmembrane transport (GO:1901679)	3.36566069
35	epoxygenase P450 pathway (GO:0019373)	3.27304902
36	digestion (GO:0007586)	3.23757239
37	cAMP catabolic process (GO:0006198)	3.23346021
38	negative regulation of cAMP-mediated signaling (GO:0043951)	3.21698629
39	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.21546749
40	regulation of protein polyubiquitination (GO:1902914)	3.20418426
41	unsaturated fatty acid metabolic process (GO:0033559)	3.18640363
42	detection of light stimulus involved in visual perception (GO:0050908)	3.14492577
43	detection of light stimulus involved in sensory perception (GO:0050962)	3.14492577
44	organelle membrane fusion (GO:0090174)	3.13150902
45	fucose catabolic process (GO:0019317)	3.09270004
46	L-fucose metabolic process (GO:0042354)	3.09270004
47	L-fucose catabolic process (GO:0042355)	3.09270004
48	protein targeting to Golgi (GO:0000042)	3.06829095
49	aminoglycoside antibiotic metabolic process (GO:0030647)	3.06670910
50	establishment of protein localization to Golgi (GO:0072600)	3.05737934
51	pH reduction (GO:0045851)	3.03545073
52	autophagic vacuole fusion (GO:0000046)	3.02990453
53	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.01388062
54	intracellular pH reduction (GO:0051452)	2.98400201
55	prostaglandin metabolic process (GO:0006693)	2.98161401
56	prostanoid metabolic process (GO:0006692)	2.98161401
57	cyclic nucleotide catabolic process (GO:0009214)	2.98002680
58	peptide biosynthetic process (GO:0043043)	2.96364721
59	lipopolysaccharide biosynthetic process (GO:0009103)	2.95465851
60	sulfur amino acid biosynthetic process (GO:0000097)	2.95430120
61	quinone metabolic process (GO:1901661)	2.94961816
62	inositol phosphate-mediated signaling (GO:0048016)	2.93277904
63	energy homeostasis (GO:0097009)	2.90630910
64	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.88957363
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.88504083
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.88504083
67	primary alcohol catabolic process (GO:0034310)	2.84294607
68	platelet dense granule organization (GO:0060155)	2.83991991
69	protein heterotetramerization (GO:0051290)	2.83255341
70	phenylpropanoid metabolic process (GO:0009698)	2.80884365
71	GDP-mannose metabolic process (GO:0019673)	2.79853475
72	C-terminal protein lipidation (GO:0006501)	2.79806364
73	metallo-sulfur cluster assembly (GO:0031163)	2.79626015
74	iron-sulfur cluster assembly (GO:0016226)	2.79626015
75	morphogenesis of an endothelium (GO:0003159)	2.78923927
76	endothelial tube morphogenesis (GO:0061154)	2.78923927
77	pattern specification involved in kidney development (GO:0061004)	2.78529988
78	heme transport (GO:0015886)	2.76623501
79	quinone biosynthetic process (GO:1901663)	2.76145317
80	base-excision repair, AP site formation (GO:0006285)	2.75679894
81	peptide metabolic process (GO:0006518)	2.75002676
82	vascular smooth muscle contraction (GO:0014829)	2.73443778
83	fatty acid elongation (GO:0030497)	2.73367325
84	interferon-gamma secretion (GO:0072643)	2.70880683
85	fatty acid biosynthetic process (GO:0006633)	2.70154846
86	mannosylation (GO:0097502)	2.69516340
87	amino acid salvage (GO:0043102)	2.69434226
88	L-methionine salvage (GO:0071267)	2.69434226
89	L-methionine biosynthetic process (GO:0071265)	2.69434226
90	regulation of cellular respiration (GO:0043457)	2.68598175
91	intestinal epithelial cell development (GO:0060576)	2.67086550
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65016728
93	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.64618730
94	ATP synthesis coupled proton transport (GO:0015986)	2.63838949
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.63838949
96	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.61644704
97	intra-Golgi vesicle-mediated transport (GO:0006891)	2.61244095
98	sodium-independent organic anion transport (GO:0043252)	2.60446776
99	positive regulation of actin filament depolymerization (GO:0030836)	2.59359579
100	cyclooxygenase pathway (GO:0019371)	2.59097305

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	9.39205531
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.48601093
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.96474278
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.72362633
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40871673
6	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.39308995
7	EGR1_19032775_ChIP-ChIP_M12_Human	2.38566447
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.32279277
9	VDR_22108803_ChIP-Seq_LS180_Human	2.30291761
10	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.22947526
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06264324
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.04196997
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.96505958
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93299855
15	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.90755335
16	GATA4_25053715_ChIP-Seq_YYC3_Human	1.82439141
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82273747
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76438703
19	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.75051866
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74628448
21	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.72964086
22	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.64663541
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.61437933
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60478404
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.59610945
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59347247
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.57416913
28	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.54506592
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53747229
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.53747229
31	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.52808165
32	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.49258226
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48508063
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.45854038
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.42638393
36	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.41650752
37	CDX2_22108803_ChIP-Seq_LS180_Human	1.39574813
38	AR_20517297_ChIP-Seq_VCAP_Human	1.34666542
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32704645
40	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.30058106
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29030790
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29030790
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28767657
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.28275306
45	GATA6_25053715_ChIP-Seq_YYC3_Human	1.25090628
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22884814
47	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.22067238
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.21570420
49	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.21322265
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21189180
51	P300_19829295_ChIP-Seq_ESCs_Human	1.19293455
52	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.19269089
53	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.18511122
54	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.17988198
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16966226
56	CBP_21632823_ChIP-Seq_H3396_Human	1.15834538
57	GATA3_26560356_Chip-Seq_TH1_Human	1.12012639
58	SOX2_20726797_ChIP-Seq_SW620_Human	1.11046257
59	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.10720900
60	ZNF274_21170338_ChIP-Seq_K562_Hela	1.08330706
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08114069
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07278162
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06934059
64	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06091675
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05565861
66	EWS_26573619_Chip-Seq_HEK293_Human	1.04801650
67	CJUN_26792858_Chip-Seq_BT549_Human	1.03255708
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01421975
69	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01000047
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99762586
71	ERG_20517297_ChIP-Seq_VCAP_Human	0.97560255
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95758249
73	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95306388
74	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.94742059
75	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.93340002
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92450972
77	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.91721533
78	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.91091079
79	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.91079341
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89759258
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89617634
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89472798
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89472798
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89320405
85	EOMES_21245162_ChIP-Seq_HESCs_Human	0.89169938
86	RXR_22108803_ChIP-Seq_LS180_Human	0.89025403
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87875714
88	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.87472922
89	NCOR_22424771_ChIP-Seq_293T_Human	0.87193128
90	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.86817185
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.86743159
92	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.86583686
93	GABP_19822575_ChIP-Seq_HepG2_Human	0.85596855
94	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85163899
95	ELF5_23300383_ChIP-Seq_T47D_Human	0.84701577
96	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.84056478
97	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.83375257
98	FOXP3_21729870_ChIP-Seq_TREG_Human	0.83024720
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.82575796
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.82351683

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	4.91230891
2	MP0004019_abnormal_vitamin_homeostasis	4.62700242
3	MP0006054_spinal_hemorrhage	4.61711735
4	MP0002163_abnormal_gland_morphology	4.37707856
5	MP0008260_abnormal_autophagy	3.62496490
6	MP0001666_abnormal_nutrient_absorption	3.19632594
7	MP0005367_renal/urinary_system_phenotyp	2.96968634
8	MP0000516_abnormal_urinary_system	2.96968634
9	MP0005379_endocrine/exocrine_gland_phen	2.94651485
10	MP0000537_abnormal_urethra_morphology	2.88088940
11	MP0005085_abnormal_gallbladder_physiolo	2.77188153
12	MP0003806_abnormal_nucleotide_metabolis	2.63802212
13	MP0008872_abnormal_physiological_respon	2.50551902
14	MP0001756_abnormal_urination	2.45429658
15	MP0005365_abnormal_bile_salt	2.44783613
16	MP0004264_abnormal_extraembryonic_tissu	2.40533649
17	MP0003195_calcinosis	2.29318912
18	MP0008875_abnormal_xenobiotic_pharmacok	2.18586787
19	MP0010386_abnormal_urinary_bladder	2.14793262
20	MP0003191_abnormal_cellular_cholesterol	2.10635405
21	MP0010030_abnormal_orbit_morphology	1.98978650
22	MP0003693_abnormal_embryo_hatching	1.88769318
23	MP0005332_abnormal_amino_acid	1.80478586
24	MP0004142_abnormal_muscle_tone	1.78386624
25	MP0001529_abnormal_vocalization	1.71829364
26	MP0003252_abnormal_bile_duct	1.62088337
27	MP0002796_impaired_skin_barrier	1.61185470
28	MP0004147_increased_porphyrin_level	1.53616220
29	MP0002089_abnormal_postnatal_growth/wei	1.52432845
30	MP0000383_abnormal_hair_follicle	1.49821364
31	MP0003718_maternal_effect	1.49602865
32	MP0001764_abnormal_homeostasis	1.43800412
33	MP0000538_abnormal_urinary_bladder	1.42463331
34	MP0001765_abnormal_ion_homeostasis	1.39899672
35	MP0000613_abnormal_salivary_gland	1.37057823
36	MP0005377_hearing/vestibular/ear_phenot	1.35276048
37	MP0003878_abnormal_ear_physiology	1.35276048
38	MP0001881_abnormal_mammary_gland	1.32823688
39	MP0005360_urolithiasis	1.30925035
40	MP0009643_abnormal_urine_homeostasis	1.25134825
41	MP0003567_abnormal_fetal_cardiomyocyte	1.24463460
42	MP0009764_decreased_sensitivity_to	1.17711028
43	MP0010678_abnormal_skin_adnexa	1.17313740
44	MP0003315_abnormal_perineum_morphology	1.15553425
45	MP0010234_abnormal_vibrissa_follicle	1.14893559
46	MP0005584_abnormal_enzyme/coenzyme_acti	1.14442126
47	MP0006035_abnormal_mitochondrial_morpho	1.11636770
48	MP0003959_abnormal_lean_body	1.11239365
49	MP0002098_abnormal_vibrissa_morphology	1.09015822
50	MP0005551_abnormal_eye_electrophysiolog	1.08893288
51	MP0002102_abnormal_ear_morphology	1.08143963
52	MP0005501_abnormal_skin_physiology	1.06761326
53	MP0005319_abnormal_enzyme/_coenzyme	1.06567842
54	MP0003186_abnormal_redox_activity	1.05535975
55	MP0004957_abnormal_blastocyst_morpholog	1.04943362
56	MP0008775_abnormal_heart_ventricle	1.04904202
57	MP0002277_abnormal_respiratory_mucosa	1.03384502
58	MP0004484_altered_response_of	1.03088652
59	MP0002136_abnormal_kidney_physiology	1.02507950
60	MP0000358_abnormal_cell_content/	1.02371517
61	MP0005166_decreased_susceptibility_to	1.01340055
62	MP0000163_abnormal_cartilage_morphology	1.01004003
63	MP0000647_abnormal_sebaceous_gland	0.99110953
64	MP0000534_abnormal_ureter_morphology	0.98995834
65	MP0000427_abnormal_hair_cycle	0.93139631
66	MP0004272_abnormal_basement_membrane	0.87230383
67	MP0002166_altered_tumor_susceptibility	0.77848735
68	MP0002006_tumorigenesis	0.77699937
69	MP0004742_abnormal_vestibular_system	0.77124502
70	MP0002009_preneoplasia	0.73199415
71	MP0009379_abnormal_foot_pigmentation	0.72589856
72	MP0003638_abnormal_response/metabolism_	0.69770687
73	MP0003936_abnormal_reproductive_system	0.65630713
74	MP0004215_abnormal_myocardial_fiber	0.65438024
75	MP0008789_abnormal_olfactory_epithelium	0.61776968
76	MP0003795_abnormal_bone_structure	0.61682167
77	MP0006036_abnormal_mitochondrial_physio	0.61594933
78	MP0005220_abnormal_exocrine_pancreas	0.61390997
79	MP0000627_abnormal_mammary_gland	0.60467798
80	MP0005666_abnormal_adipose_tissue	0.59748518
81	MP0002118_abnormal_lipid_homeostasis	0.56691499
82	MP0005645_abnormal_hypothalamus_physiol	0.56437679
83	MP0008877_abnormal_DNA_methylation	0.56283865
84	MP0000462_abnormal_digestive_system	0.55714034
85	MP0000026_abnormal_inner_ear	0.54881465
86	MP0005395_other_phenotype	0.54345571
87	MP0001963_abnormal_hearing_physiology	0.53343125
88	MP0003866_abnormal_defecation	0.52407235
89	MP0010352_gastrointestinal_tract_polyps	0.51602294
90	MP0000639_abnormal_adrenal_gland	0.51549307
91	MP0002115_abnormal_skeleton_extremities	0.51127567
92	MP0010155_abnormal_intestine_physiology	0.50646612
93	MP0008469_abnormal_protein_level	0.50559895
94	MP0003950_abnormal_plasma_membrane	0.50442116
95	MP0005330_cardiomyopathy	0.49824543
96	MP0002932_abnormal_joint_morphology	0.49802274
97	MP0010329_abnormal_lipoprotein_level	0.49608454
98	MP0001485_abnormal_pinna_reflex	0.46446868
99	MP0005257_abnormal_intraocular_pressure	0.45066300
100	MP0001905_abnormal_dopamine_level	0.44801180

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.64024946
2	Hypoplasia of the fovea (HP:0007750)	5.64024946
3	Abnormality of the fovea (HP:0000493)	5.41561267
4	Central scotoma (HP:0000603)	4.79067478
5	Abnormality of macular pigmentation (HP:0008002)	4.56895872
6	Congenital stationary night blindness (HP:0007642)	4.46804853
7	Abnormality of alanine metabolism (HP:0010916)	4.16090819
8	Hyperalaninemia (HP:0003348)	4.16090819
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.16090819
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.80933312
11	Severe visual impairment (HP:0001141)	3.65759310
12	Scotoma (HP:0000575)	3.60643527
13	Abnormality of glycolipid metabolism (HP:0010969)	3.58767836
14	Abnormality of liposaccharide metabolism (HP:0010968)	3.58767836
15	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.58767836
16	Aplasia/Hypoplasia of the macula (HP:0008059)	3.48119358
17	Congenital, generalized hypertrichosis (HP:0004540)	3.43228120
18	J-shaped sella turcica (HP:0002680)	3.28896098
19	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.23124545
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.07786422
21	Rib fusion (HP:0000902)	2.95273197
22	Carpal bone hypoplasia (HP:0001498)	2.93549738
23	Tongue fasciculations (HP:0001308)	2.82924035
24	Anomalous pulmonary venous return (HP:0010772)	2.81397570
25	Broad alveolar ridges (HP:0000187)	2.78968553
26	Hepatic necrosis (HP:0002605)	2.78460973
27	Steatorrhea (HP:0002570)	2.75293144
28	Fat malabsorption (HP:0002630)	2.74516283
29	Short tibia (HP:0005736)	2.72994609
30	Type I transferrin isoform profile (HP:0003642)	2.61139585
31	Hepatocellular necrosis (HP:0001404)	2.56954620
32	Microglossia (HP:0000171)	2.55912211
33	Microretrognathia (HP:0000308)	2.52822550
34	Vascular calcification (HP:0004934)	2.50283145
35	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.49905319
36	Vertebral arch anomaly (HP:0008438)	2.43803026
37	Abnormality of the pulmonary veins (HP:0011718)	2.39018485
38	Nonprogressive disorder (HP:0003680)	2.38705568
39	Broad ribs (HP:0000885)	2.35463665
40	Abnormality of the sella turcica (HP:0002679)	2.35164099
41	Tetraparesis (HP:0002273)	2.32374041
42	Muscle fibrillation (HP:0010546)	2.29167267
43	Nausea (HP:0002018)	2.28685659
44	CNS demyelination (HP:0007305)	2.27812119
45	Intrahepatic cholestasis (HP:0001406)	2.21712877
46	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.21234375
47	Lipid accumulation in hepatocytes (HP:0006561)	2.17149197
48	Increased serum ferritin (HP:0003281)	2.16114188
49	Conjugated hyperbilirubinemia (HP:0002908)	2.14261303
50	Beaking of vertebral bodies (HP:0004568)	2.13956663
51	Abnormality of urine glucose concentration (HP:0011016)	2.12771377
52	Glycosuria (HP:0003076)	2.12771377
53	Abnormality of proline metabolism (HP:0010907)	2.12683428
54	Hydroxyprolinuria (HP:0003080)	2.12683428
55	Abnormality of the lumbar spine (HP:0100712)	2.12270730
56	Diastasis recti (HP:0001540)	2.08552212
57	Opisthotonus (HP:0002179)	2.08545440
58	Adrenal hypoplasia (HP:0000835)	2.04494565
59	Pancreatitis (HP:0001733)	2.04234857
60	Proximal tubulopathy (HP:0000114)	2.01991778
61	Thickened calvaria (HP:0002684)	2.01695665
62	Renal tubular acidosis (HP:0001947)	2.01115826
63	Cardiovascular calcification (HP:0011915)	1.99069470
64	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.95979142
65	Generalized aminoaciduria (HP:0002909)	1.94433863
66	Increased hepatocellular lipid droplets (HP:0006565)	1.94281544
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.94073072
68	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.94073072
69	Genetic anticipation (HP:0003743)	1.94063262
70	Abnormality of renal resorption (HP:0011038)	1.93462070
71	Abnormality of polysaccharide metabolism (HP:0011012)	1.93047095
72	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.93047095
73	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.93047095
74	Facial diplegia (HP:0001349)	1.93022732
75	Flared iliac wings (HP:0002869)	1.91789347
76	Renal Fanconi syndrome (HP:0001994)	1.91501095
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90092994
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.90092994
79	Abnormal protein glycosylation (HP:0012346)	1.90092994
80	Abnormal glycosylation (HP:0012345)	1.90092994
81	Increased serum lactate (HP:0002151)	1.87635597
82	Abnormality of serum amino acid levels (HP:0003112)	1.87196971
83	Urinary glycosaminoglycan excretion (HP:0003541)	1.86196600
84	Mucopolysacchariduria (HP:0008155)	1.86196600
85	Reduced subcutaneous adipose tissue (HP:0003758)	1.85936228
86	Abnormality of pyrimidine metabolism (HP:0004353)	1.85536596
87	Thoracic kyphosis (HP:0002942)	1.85516080
88	Prolonged neonatal jaundice (HP:0006579)	1.85458429
89	Pustule (HP:0200039)	1.84848139
90	Toxemia of pregnancy (HP:0100603)	1.84309037
91	Mitochondrial inheritance (HP:0001427)	1.83207912
92	Increased CSF lactate (HP:0002490)	1.82284534
93	Recurrent bronchitis (HP:0002837)	1.78923155
94	Abnormality of iron homeostasis (HP:0011031)	1.78399825
95	Lethargy (HP:0001254)	1.78243298
96	Back pain (HP:0003418)	1.75798571
97	Renal tubular dysfunction (HP:0000124)	1.75734145
98	Hypoplastic pelvis (HP:0008839)	1.75549154
99	Deformed sella turcica (HP:0002681)	1.74505591
100	Hypoplasia of the odontoid process (HP:0003311)	1.73375721

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.54670428
2	VRK2	3.42692780
3	FRK	3.26940397
4	MAP3K12	2.88386674
5	MST4	2.83115142
6	TESK1	2.62529152
7	YES1	2.60401594
8	BCKDK	2.55908639
9	LIMK1	2.48506569
10	WNK4	2.27504116
11	TAF1	2.22352388
12	NME2	2.19355766
13	TESK2	2.15407578
14	CAMKK2	2.06769496
15	BMPR2	1.94669001
16	PDK2	1.86713642
17	PTK2B	1.81061356
18	ERBB3	1.79730171
19	MAP3K2	1.70602193
20	MAPKAPK3	1.66490035
21	MAP4K2	1.65720358
22	STK16	1.43804442
23	PAK4	1.39755015
24	MYLK	1.37934173
25	AKT2	1.37704272
26	DAPK1	1.32251474
27	GRK1	1.29086669
28	STK39	1.26937030
29	OXSR1	1.24243753
30	NEK1	1.22298573
31	CSNK1G3	1.20462596
32	RPS6KB2	1.17769789
33	CDK19	1.16476331
34	ACVR1B	1.14174821
35	ABL2	1.13992510
36	CSNK1A1L	1.10831114
37	MST1R	1.10138371
38	MET	1.09343413
39	SRPK1	1.05532630
40	LMTK2	1.03486183
41	VRK1	1.02853770
42	CSNK1G1	0.99729554
43	DYRK1B	0.94535253
44	CSNK1G2	0.93148829
45	FER	0.89565188
46	NME1	0.88577463
47	GRK6	0.85665431
48	TRIM28	0.84744504
49	NUAK1	0.84082566
50	ADRBK1	0.82717505
51	CAMK4	0.82465375
52	MAP2K7	0.82408987
53	PIM2	0.82113051
54	HIPK2	0.77534694
55	GRK5	0.77141353
56	NLK	0.76520937
57	EPHB2	0.76307127
58	RIPK4	0.72735869
59	RPS6KA4	0.71276870
60	KDR	0.70699452
61	IRAK3	0.70077324
62	MUSK	0.64100138
63	DAPK3	0.62972414
64	ADRBK2	0.61466089
65	MAP3K3	0.58969981
66	CAMK2G	0.57682488
67	ERBB4	0.55740040
68	INSRR	0.52972099
69	PIM1	0.52541357
70	TNIK	0.52375573
71	IKBKB	0.52174477
72	ERBB2	0.51577714
73	CLK1	0.50938181
74	ZAK	0.49452588
75	CAMK2D	0.48985337
76	CAMK2A	0.48931777
77	RPS6KA6	0.47690893
78	WNK3	0.47224220
79	MAP2K2	0.45717091
80	EPHA4	0.42681617
81	TSSK6	0.42304349
82	FLT3	0.42226896
83	MAP3K5	0.42169047
84	STK38L	0.41360513
85	CAMK1	0.40343345
86	ILK	0.38894306
87	WEE1	0.36265283
88	PRKCE	0.36194356
89	BLK	0.35948663
90	FGR	0.35828448
91	AURKB	0.35818738
92	CSNK1A1	0.34999938
93	CDK6	0.34799621
94	UHMK1	0.34241006
95	BUB1	0.33519578
96	PLK2	0.33129731
97	ROCK1	0.32700596
98	PRKG1	0.30997540
99	PRKCA	0.28670140
100	RPS6KA5	0.28103997

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	6.45415929
2	Proteasome_Homo sapiens_hsa03050	3.41196303
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.32880058
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.56304790
5	Sulfur relay system_Homo sapiens_hsa04122	2.43163564
6	Fat digestion and absorption_Homo sapiens_hsa04975	2.37607608
7	Glutathione metabolism_Homo sapiens_hsa00480	2.26732315
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.17496486
9	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.90407868
10	Nitrogen metabolism_Homo sapiens_hsa00910	1.84603488
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79024970
12	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.74822580
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.73806775
14	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.73202355
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.69593957
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67230974
17	Ribosome_Homo sapiens_hsa03010	1.64507351
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.63785834
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63751104
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.63201636
21	Alzheimers disease_Homo sapiens_hsa05010	1.60338872
22	Parkinsons disease_Homo sapiens_hsa05012	1.59089068
23	Protein digestion and absorption_Homo sapiens_hsa04974	1.58201594
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.53997644
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.52946675
26	Fatty acid elongation_Homo sapiens_hsa00062	1.51115111
27	Pancreatic secretion_Homo sapiens_hsa04972	1.49840584
28	Caffeine metabolism_Homo sapiens_hsa00232	1.39832681
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.38166486
30	Huntingtons disease_Homo sapiens_hsa05016	1.36341979
31	Regulation of autophagy_Homo sapiens_hsa04140	1.35863723
32	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.19773029
33	Renin-angiotensin system_Homo sapiens_hsa04614	1.19210494
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14781153
35	Folate biosynthesis_Homo sapiens_hsa00790	1.11666054
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11466008
37	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.04924849
38	RNA polymerase_Homo sapiens_hsa03020	1.02737403
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01856827
40	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.99995567
41	Base excision repair_Homo sapiens_hsa03410	0.99410855
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97960091
43	Purine metabolism_Homo sapiens_hsa00230	0.97439436
44	Sulfur metabolism_Homo sapiens_hsa00920	0.97286925
45	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.96292690
46	Protein export_Homo sapiens_hsa03060	0.92935598
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91886533
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.91659501
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.90100891
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85010301
51	Fatty acid degradation_Homo sapiens_hsa00071	0.82966850
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82515079
53	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.82349851
54	Retinol metabolism_Homo sapiens_hsa00830	0.81627024
55	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81284611
56	Galactose metabolism_Homo sapiens_hsa00052	0.80623374
57	Renin secretion_Homo sapiens_hsa04924	0.80442593
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80199311
59	Peroxisome_Homo sapiens_hsa04146	0.77531021
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74896211
61	Histidine metabolism_Homo sapiens_hsa00340	0.74114117
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.74103503
63	Metabolic pathways_Homo sapiens_hsa01100	0.72312971
64	Basal transcription factors_Homo sapiens_hsa03022	0.71400379
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69624506
66	Propanoate metabolism_Homo sapiens_hsa00640	0.69355079
67	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69184242
68	Phototransduction_Homo sapiens_hsa04744	0.67993056
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67731052
70	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67211729
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.66542211
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.65815911
73	Homologous recombination_Homo sapiens_hsa03440	0.63728017
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62847211
75	Mineral absorption_Homo sapiens_hsa04978	0.61211528
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.57063977
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55928790
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.54706342
79	Salivary secretion_Homo sapiens_hsa04970	0.54577044
80	RNA transport_Homo sapiens_hsa03013	0.51204863
81	Amphetamine addiction_Homo sapiens_hsa05031	0.47357085
82	DNA replication_Homo sapiens_hsa03030	0.44732541
83	Mismatch repair_Homo sapiens_hsa03430	0.44403376
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43950586
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.43454143
86	Carbon metabolism_Homo sapiens_hsa01200	0.42614127
87	Asthma_Homo sapiens_hsa05310	0.42136631
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40665157
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.37618610
90	Tight junction_Homo sapiens_hsa04530	0.33275105
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.32156715
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.31213423
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30375057
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29643883
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.27568123
96	Vibrio cholerae infection_Homo sapiens_hsa05110	0.25223287
97	Lysosome_Homo sapiens_hsa04142	0.24673131
98	Small cell lung cancer_Homo sapiens_hsa05222	0.24346505
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22402120
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.18931311

KRT8P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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