ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil chemotaxis (GO:0048245)	8.24592298
2	eosinophil migration (GO:0072677)	7.35222101
3	sulfation (GO:0051923)	6.95166069
4	protein K11-linked deubiquitination (GO:0035871)	6.45637034
5	flavonoid metabolic process (GO:0009812)	6.18559372
6	notochord development (GO:0030903)	5.91616660
7	positive regulation of cAMP-mediated signaling (GO:0043950)	5.46023471
8	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.95908378
9	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	4.79087073
10	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	4.79087073
11	cellular response to ethanol (GO:0071361)	4.50262521
12	inner ear receptor cell development (GO:0060119)	4.49137155
13	regulation of Cdc42 GTPase activity (GO:0043088)	4.45857819
14	peristalsis (GO:0030432)	4.27864473
15	phasic smooth muscle contraction (GO:0014821)	4.07067950
16	regulation of interferon-beta biosynthetic process (GO:0045357)	3.93072055
17	cellular response to exogenous dsRNA (GO:0071360)	3.89381850
18	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.77354946
19	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.77354946
20	modulation by symbiont of host immune response (GO:0052553)	3.77354946
21	positive regulation by symbiont of host defense response (GO:0052509)	3.77354946
22	modulation by symbiont of host defense response (GO:0052031)	3.77354946
23	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.77354946
24	ribonucleoside bisphosphate metabolic process (GO:0033875)	3.69777557
25	nucleoside bisphosphate metabolic process (GO:0033865)	3.69777557
26	purine nucleoside bisphosphate metabolic process (GO:0034032)	3.69777557
27	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.63135386
28	desmosome organization (GO:0002934)	3.60273800
29	vitamin transmembrane transport (GO:0035461)	3.56761670
30	multicellular organism reproduction (GO:0032504)	3.43556192
31	basic amino acid transport (GO:0015802)	3.38560064
32	regulation of mononuclear cell migration (GO:0071675)	3.35552299
33	regulation of integrin-mediated signaling pathway (GO:2001044)	3.33800260
34	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.25712517
35	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.24541535
36	urinary tract smooth muscle contraction (GO:0014848)	3.24521809
37	alanine transport (GO:0032328)	3.20660968
38	regulation of macrophage chemotaxis (GO:0010758)	3.18318908
39	positive regulation of growth hormone secretion (GO:0060124)	3.13224705
40	positive regulation of osteoblast proliferation (GO:0033690)	3.12763565
41	glycine transport (GO:0015816)	3.11774944
42	artery smooth muscle contraction (GO:0014824)	3.11326640
43	angiogenesis involved in wound healing (GO:0060055)	3.11217523
44	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.09528272
45	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.07706300
46	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.03600642
47	regulation of cAMP-mediated signaling (GO:0043949)	3.01132069
48	peptidyl-threonine dephosphorylation (GO:0035970)	3.00557515
49	autophagic vacuole fusion (GO:0000046)	2.99699836
50	cysteine metabolic process (GO:0006534)	2.96731080
51	response to host immune response (GO:0052572)	2.95970484
52	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.95970484
53	behavioral response to nicotine (GO:0035095)	2.94740959
54	reflex (GO:0060004)	2.94499723
55	serotonin receptor signaling pathway (GO:0007210)	2.90833830
56	regulation of cell proliferation involved in kidney development (GO:1901722)	2.90607077
57	energy homeostasis (GO:0097009)	2.86428947
58	omega-hydroxylase P450 pathway (GO:0097267)	2.85383080
59	striated muscle atrophy (GO:0014891)	2.84112532
60	regulation of establishment of cell polarity (GO:2000114)	2.82803279
61	interferon-gamma secretion (GO:0072643)	2.82790890
62	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.81909539
63	positive regulation of hair cycle (GO:0042635)	2.80996309
64	positive regulation of hair follicle development (GO:0051798)	2.80996309
65	negative regulation of metanephros development (GO:0072217)	2.76384264
66	hematopoietic stem cell proliferation (GO:0071425)	2.74870084
67	amino-acid betaine metabolic process (GO:0006577)	2.71583659
68	cellular glucuronidation (GO:0052695)	2.71411188
69	multicellular organismal movement (GO:0050879)	2.71226857
70	musculoskeletal movement (GO:0050881)	2.71226857
71	response to UV-C (GO:0010225)	2.70114614
72	glucuronate metabolic process (GO:0019585)	2.69801434
73	uronic acid metabolic process (GO:0006063)	2.69801434
74	coenzyme A metabolic process (GO:0015936)	2.66540793
75	response to defenses of other organism involved in symbiotic interaction (GO:0052173)	2.64901343
76	response to host (GO:0075136)	2.64901343
77	response to host defenses (GO:0052200)	2.64901343
78	biotin metabolic process (GO:0006768)	2.64347696
79	regulation of G0 to G1 transition (GO:0070316)	2.64065660
80	positive regulation of digestive system process (GO:0060456)	2.64024093
81	mesonephros development (GO:0001823)	2.60980149
82	tonic smooth muscle contraction (GO:0014820)	2.60941964
83	digestion (GO:0007586)	2.59935490
84	negative regulation of interleukin-8 production (GO:0032717)	2.59326389
85	glycerophospholipid catabolic process (GO:0046475)	2.58404678
86	carnitine transport (GO:0015879)	2.55514797
87	amino-acid betaine transport (GO:0015838)	2.55514797
88	xenobiotic catabolic process (GO:0042178)	2.52535993
89	regulation of posttranscriptional gene silencing (GO:0060147)	2.51944111
90	regulation of gene silencing by miRNA (GO:0060964)	2.51944111
91	regulation of gene silencing by RNA (GO:0060966)	2.51944111
92	negative regulation of hormone metabolic process (GO:0032351)	2.51741964
93	keratinocyte development (GO:0003334)	2.49894662
94	transepithelial transport (GO:0070633)	2.48612209
95	lytic vacuole organization (GO:0080171)	2.48507164
96	lysosome organization (GO:0007040)	2.48507164
97	regulation of hypersensitivity (GO:0002883)	2.46932069
98	endocardial cushion development (GO:0003197)	2.46779437
99	regulation of hippo signaling (GO:0035330)	2.46253646
100	nephron tubule formation (GO:0072079)	2.46065233

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.65214906
2	ESR1_21235772_ChIP-Seq_MCF-7_Human	4.37371010
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.78494166
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.57595592
5	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.34650214
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.28812566
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.99040874
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.65524500
9	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.55188913
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.42688464
11	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.19448114
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.99235095
13	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.98195318
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91619777
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90809855
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.80818311
17	ERA_21632823_ChIP-Seq_H3396_Human	1.79050088
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.78610644
19	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.71353236
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70871642
21	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.70244369
22	GATA4_25053715_ChIP-Seq_YYC3_Human	1.65479167
23	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.63806763
24	SOX2_20726797_ChIP-Seq_SW620_Human	1.59417328
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.57160826
26	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.49899417
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.42995078
28	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.41701498
29	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.38401591
30	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.36733588
31	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.34288215
32	GATA6_25053715_ChIP-Seq_YYC3_Human	1.32641740
33	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.28045458
34	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.27408482
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.27249226
36	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27002953
37	RAC3_21632823_ChIP-Seq_H3396_Human	1.25064207
38	DROSHA_22980978_ChIP-Seq_HELA_Human	1.23510280
39	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.23319398
40	STAT1_20625510_ChIP-Seq_HELA_Human	1.23259885
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.22588883
42	E2F1_20622854_ChIP-Seq_HELA_Human	1.22453388
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22363833
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22363833
45	HOXB7_26014856_ChIP-Seq_BT474_Human	1.21848229
46	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.21674533
47	GATA1_22025678_ChIP-Seq_K562_Human	1.18355950
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17503487
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15128072
50	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12964655
51	AHR_22903824_ChIP-Seq_MCF-7_Human	1.11928996
52	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.11744002
53	SPI1_20517297_ChIP-Seq_HL60_Human	1.11508858
54	CDX2_22108803_ChIP-Seq_LS180_Human	1.10613008
55	PHF8_20622853_ChIP-Seq_HELA_Human	1.10597073
56	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.10369483
57	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.09594806
58	TP53_16413492_ChIP-PET_HCT116_Human	1.09370914
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.08968276
60	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.06960648
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06345351
62	CTCF_20526341_ChIP-Seq_ESCs_Human	1.03856043
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.02057819
64	AR_25329375_ChIP-Seq_VCAP_Human	1.02036179
65	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01278962
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.01001928
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00165775
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.00165775
69	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.98331185
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97619802
71	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96913276
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.95909094
73	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.95853327
74	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.95147802
75	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.95129566
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93260617
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92165198
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91229494
79	PHF8_20622854_ChIP-Seq_HELA_Human	0.90858992
80	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.90682578
81	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90434090
82	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.90401840
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.89620648
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.89252310
85	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.89056888
86	ELF5_23300383_ChIP-Seq_T47D_Human	0.88575477
87	BCOR_27268052_Chip-Seq_Bcells_Human	0.88401823
88	NCOR_22424771_ChIP-Seq_293T_Human	0.88038908
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87831684
90	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87348104
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86594267
92	KDM5A_27292631_Chip-Seq_BREAST_Human	0.86585952
93	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.85235559
94	TP53_18474530_ChIP-ChIP_U2OS_Human	0.84655700
95	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.84402174
96	AR_20517297_ChIP-Seq_VCAP_Human	0.84212042
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.82910735
98	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.82863875
99	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.81591622
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.81571412

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	6.73200242
2	MP0008875_abnormal_xenobiotic_pharmacok	5.58799134
3	MP0002163_abnormal_gland_morphology	5.49947431
4	MP0003195_calcinosis	3.96365990
5	MP0002102_abnormal_ear_morphology	3.35823273
6	MP0005379_endocrine/exocrine_gland_phen	3.34587906
7	MP0005377_hearing/vestibular/ear_phenot	3.06984108
8	MP0003878_abnormal_ear_physiology	3.06984108
9	MP0003806_abnormal_nucleotide_metabolis	2.93758357
10	MP0003950_abnormal_plasma_membrane	2.67776169
11	MP0002277_abnormal_respiratory_mucosa	2.48964692
12	MP0008872_abnormal_physiological_respon	2.44925298
13	MP0002139_abnormal_hepatobiliary_system	2.40261872
14	MP0010386_abnormal_urinary_bladder	2.15028206
15	MP0000613_abnormal_salivary_gland	2.13863628
16	MP0002148_abnormal_hypersensitivity_rea	2.13565632
17	MP0005551_abnormal_eye_electrophysiolog	1.97055765
18	MP0004043_abnormal_pH_regulation	1.81219770
19	MP0005360_urolithiasis	1.70807652
20	MP0001666_abnormal_nutrient_absorption	1.62623858
21	MP0003191_abnormal_cellular_cholesterol	1.53981029
22	MP0005670_abnormal_white_adipose	1.53430031
23	MP0005410_abnormal_fertilization	1.43164092
24	MP0005084_abnormal_gallbladder_morpholo	1.42864693
25	MP0005671_abnormal_response_to	1.34652434
26	MP0005332_abnormal_amino_acid	1.31540070
27	MP0009780_abnormal_chondrocyte_physiolo	1.29228287
28	MP0005365_abnormal_bile_salt	1.28365532
29	MP0001485_abnormal_pinna_reflex	1.28359602
30	MP0002089_abnormal_postnatal_growth/wei	1.23982098
31	MP0004233_abnormal_muscle_weight	1.19884560
32	MP0003315_abnormal_perineum_morphology	1.18123957
33	MP0001986_abnormal_taste_sensitivity	1.17328525
34	MP0006082_CNS_inflammation	1.17026733
35	MP0003936_abnormal_reproductive_system	1.16399606
36	MP0004147_increased_porphyrin_level	1.14769937
37	MP0000750_abnormal_muscle_regeneration	1.14577885
38	MP0003959_abnormal_lean_body	1.13636803
39	MP0000538_abnormal_urinary_bladder	1.12957030
40	MP0004134_abnormal_chest_morphology	1.09723628
41	MP0002138_abnormal_hepatobiliary_system	1.08747025
42	MP0005167_abnormal_blood-brain_barrier	1.05996841
43	MP0005647_abnormal_sex_gland	1.03868757
44	MP0005310_abnormal_salivary_gland	1.02754727
45	MP0001501_abnormal_sleep_pattern	1.01047894
46	MP0001324_abnormal_eye_pigmentation	1.00319594
47	MP0005319_abnormal_enzyme/_coenzyme	0.99923147
48	MP0004185_abnormal_adipocyte_glucose	0.99121297
49	MP0002098_abnormal_vibrissa_morphology	0.98689069
50	MP0009785_altered_susceptibility_to	0.98432214
51	MP0009643_abnormal_urine_homeostasis	0.98202745
52	MP0009840_abnormal_foam_cell	0.97292633
53	MP0000920_abnormal_myelination	0.96416035
54	MP0001968_abnormal_touch/_nociception	0.95243978
55	MP0002909_abnormal_adrenal_gland	0.94633395
56	MP0005451_abnormal_body_composition	0.92856609
57	MP0004130_abnormal_muscle_cell	0.91546224
58	MP0000427_abnormal_hair_cycle	0.90483660
59	MP0003693_abnormal_embryo_hatching	0.89869284
60	MP0008469_abnormal_protein_level	0.86257936
61	MP0000015_abnormal_ear_pigmentation	0.85977074
62	MP0002136_abnormal_kidney_physiology	0.85857083
63	MP0002254_reproductive_system_inflammat	0.85815497
64	MP0000462_abnormal_digestive_system	0.84197228
65	MP0002160_abnormal_reproductive_system	0.83645283
66	MP0005389_reproductive_system_phenotype	0.82659301
67	MP0005058_abnormal_lysosome_morphology	0.80732813
68	MP0004381_abnormal_hair_follicle	0.80421618
69	MP0002118_abnormal_lipid_homeostasis	0.79848098
70	MP0001800_abnormal_humoral_immune	0.79137520
71	MP0005584_abnormal_enzyme/coenzyme_acti	0.79032667
72	MP0001765_abnormal_ion_homeostasis	0.78706704
73	MP0002452_abnormal_antigen_presenting	0.78555138
74	MP0004019_abnormal_vitamin_homeostasis	0.78503520
75	MP0000230_abnormal_systemic_arterial	0.72632153
76	MP0005000_abnormal_immune_tolerance	0.71755076
77	MP0005025_abnormal_response_to	0.71540882
78	MP0002733_abnormal_thermal_nociception	0.70778041
79	MP0005085_abnormal_gallbladder_physiolo	0.70508526
80	MP0008874_decreased_physiological_sensi	0.69342679
81	MP0002723_abnormal_immune_serum	0.68977908
82	MP0001845_abnormal_inflammatory_respons	0.67391617
83	MP0000647_abnormal_sebaceous_gland	0.67171017
84	MP0000749_muscle_degeneration	0.67028917
85	MP0010329_abnormal_lipoprotein_level	0.65473377
86	MP0000358_abnormal_cell_content/	0.63658482
87	MP0000383_abnormal_hair_follicle	0.61142202
88	MP0005164_abnormal_response_to	0.61127169
89	MP0002876_abnormal_thyroid_physiology	0.59257779
90	MP0001970_abnormal_pain_threshold	0.57477592
91	MP0003718_maternal_effect	0.56923846
92	MP0000627_abnormal_mammary_gland	0.56056067
93	MP0009642_abnormal_blood_homeostasis	0.56005550
94	MP0001835_abnormal_antigen_presentation	0.55686311
95	MP0009764_decreased_sensitivity_to	0.54239166
96	MP0009333_abnormal_splenocyte_physiolog	0.51889849
97	MP0001873_stomach_inflammation	0.51503018
98	MP0001919_abnormal_reproductive_system	0.51488359
99	MP0005195_abnormal_posterior_eye	0.51380449
100	MP0000537_abnormal_urethra_morphology	0.50689564

Predicted human phenotypes

Rank	Gene Set	Z-score
1	J-shaped sella turcica (HP:0002680)	5.05661631
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.77731967
3	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	4.12082937
4	Abolished electroretinogram (ERG) (HP:0000550)	4.07924566
5	Increased cerebral lipofuscin (HP:0011813)	3.97743297
6	Abnormality of proline metabolism (HP:0010907)	3.94334679
7	Hydroxyprolinuria (HP:0003080)	3.94334679
8	True hermaphroditism (HP:0010459)	3.82334315
9	Abnormality of liposaccharide metabolism (HP:0010968)	3.60832405
10	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.60832405
11	Abnormality of glycolipid metabolism (HP:0010969)	3.60832405
12	Tinnitus (HP:0000360)	3.33432838
13	Abnormality of the odontoid process (HP:0003310)	3.23999828
14	Clumsiness (HP:0002312)	3.13249904
15	Abnormality of the fetal cardiovascular system (HP:0010948)	3.07167703
16	Abnormal umbilical cord blood vessels (HP:0011403)	3.07167703
17	Single umbilical artery (HP:0001195)	3.07167703
18	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.90421099
19	Attenuation of retinal blood vessels (HP:0007843)	2.88854022
20	Abnormality of polysaccharide metabolism (HP:0011012)	2.85871297
21	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.85871297
22	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.85871297
23	Urinary glycosaminoglycan excretion (HP:0003541)	2.82775906
24	Mucopolysacchariduria (HP:0008155)	2.82775906
25	Unilateral renal agenesis (HP:0000122)	2.79034960
26	Pancreatic cysts (HP:0001737)	2.78545904
27	Hypoplasia of the odontoid process (HP:0003311)	2.76225413
28	Pancreatic fibrosis (HP:0100732)	2.75813735
29	Macular degeneration (HP:0000608)	2.68052935
30	Absent speech (HP:0001344)	2.67276085
31	Vacuolated lymphocytes (HP:0001922)	2.65519587
32	Cheilitis (HP:0100825)	2.64140045
33	Decreased central vision (HP:0007663)	2.62227694
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59998679
35	Abnormality of alanine metabolism (HP:0010916)	2.59998679
36	Hyperalaninemia (HP:0003348)	2.59998679
37	Chorioretinal atrophy (HP:0000533)	2.59427688
38	Amelogenesis imperfecta (HP:0000705)	2.58131670
39	Carpal bone hypoplasia (HP:0001498)	2.56309993
40	Deformed sella turcica (HP:0002681)	2.56187432
41	Furrowed tongue (HP:0000221)	2.55576357
42	Bilateral sensorineural hearing impairment (HP:0008619)	2.54940193
43	Hyperglycinuria (HP:0003108)	2.53373171
44	Anomalous pulmonary venous return (HP:0010772)	2.52447226
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46234225
46	Dysostosis multiplex (HP:0000943)	2.43298179
47	Abnormality of the umbilical cord (HP:0010881)	2.43057075
48	Severe muscular hypotonia (HP:0006829)	2.40130356
49	Esophageal neoplasm (HP:0100751)	2.38241319
50	Neoplasm of head and neck (HP:0012288)	2.38241319
51	Systemic lupus erythematosus (HP:0002725)	2.37787611
52	Poikiloderma (HP:0001029)	2.36184595
53	Abnormality of the sella turcica (HP:0002679)	2.35912051
54	Confusion (HP:0001289)	2.29568704
55	Abnormality of dental color (HP:0011073)	2.27424032
56	Vascular calcification (HP:0004934)	2.26980681
57	Cystic liver disease (HP:0006706)	2.22347203
58	Glomerulosclerosis (HP:0000096)	2.18761199
59	Recurrent pneumonia (HP:0006532)	2.18024453
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17239491
61	Congenital sensorineural hearing impairment (HP:0008527)	2.13934915
62	Ovoid vertebral bodies (HP:0003300)	2.13874839
63	Ileus (HP:0002595)	2.13686835
64	Large for gestational age (HP:0001520)	2.13049508
65	Abnormality of the lumbar spine (HP:0100712)	2.12956868
66	Hypoplastic pelvis (HP:0008839)	2.11933572
67	Palpebral edema (HP:0100540)	2.11643280
68	Concave nail (HP:0001598)	2.09119977
69	Hypotrichosis (HP:0001006)	2.08894746
70	Prostate neoplasm (HP:0100787)	2.08801956
71	Abnormality of the pulmonary veins (HP:0011718)	2.07805828
72	Severe visual impairment (HP:0001141)	2.06081961
73	Flared iliac wings (HP:0002869)	2.05909477
74	Hyperventilation (HP:0002883)	2.05841287
75	Diastasis recti (HP:0001540)	2.02162579
76	Genetic anticipation (HP:0003743)	2.01372000
77	Focal segmental glomerulosclerosis (HP:0000097)	2.00802886
78	Beaking of vertebral bodies (HP:0004568)	1.99252794
79	Hyperammonemia (HP:0001987)	1.94699136
80	Abnormality of the renal cortex (HP:0011035)	1.94607653
81	Conical tooth (HP:0000698)	1.92992031
82	Bundle branch block (HP:0011710)	1.92519934
83	Cardiovascular calcification (HP:0011915)	1.91877897
84	Inability to walk (HP:0002540)	1.89040953
85	Thoracic kyphosis (HP:0002942)	1.88876909
86	Flat acetabular roof (HP:0003180)	1.85873308
87	Tubular atrophy (HP:0000092)	1.85111805
88	Constricted visual fields (HP:0001133)	1.84850367
89	Nephronophthisis (HP:0000090)	1.84228465
90	Widely spaced teeth (HP:0000687)	1.82567888
91	Protuberant abdomen (HP:0001538)	1.81427121
92	Azoospermia (HP:0000027)	1.81353186
93	Late onset (HP:0003584)	1.80736928
94	Thoracolumbar scoliosis (HP:0002944)	1.78957678
95	Rough bone trabeculation (HP:0100670)	1.78694965
96	Stage 5 chronic kidney disease (HP:0003774)	1.78564656
97	Abnormality of chloride homeostasis (HP:0011422)	1.75311152
98	Hypoplastic ischia (HP:0003175)	1.73174110
99	Abnormality of midbrain morphology (HP:0002418)	1.72431006
100	Molar tooth sign on MRI (HP:0002419)	1.72431006

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	6.90313532
2	ADRBK2	4.87523415
3	NME1	3.81437293
4	LMTK2	3.61929638
5	FRK	3.56392312
6	TLK1	3.39172059
7	EPHA2	3.01955032
8	MAP3K12	2.96777738
9	TXK	2.73846262
10	MAPKAPK3	2.34816491
11	GRK1	2.26360326
12	WNK4	1.99080871
13	LIMK1	1.96898547
14	ZAK	1.96849071
15	MYLK	1.44680604
16	TESK2	1.43335815
17	NEK2	1.38659413
18	DAPK1	1.36979248
19	TRIB3	1.35089068
20	EIF2AK3	1.34522991
21	BUB1	1.28750154
22	NEK1	1.26022970
23	BCKDK	1.21523412
24	VRK2	1.20844230
25	PDK2	1.16771654
26	MST1R	1.15577465
27	ADRBK1	1.11992713
28	STK39	1.08015090
29	FER	1.07184483
30	WNK3	1.06056483
31	MST4	1.02120534
32	BRSK2	1.00607041
33	RPS6KB2	1.00426520
34	TAF1	0.96138327
35	PINK1	0.93781781
36	MAPKAPK5	0.92488672
37	CDK12	0.86802123
38	VRK1	0.82791587
39	PIK3CA	0.82314079
40	TESK1	0.77282732
41	ILK	0.74499201
42	NEK6	0.74003550
43	GRK6	0.73407916
44	DAPK3	0.72654821
45	PBK	0.72410298
46	MET	0.71541265
47	MAP3K4	0.67590964
48	IRAK4	0.67534815
49	SYK	0.66412950
50	OXSR1	0.63100164
51	PAK4	0.63041277
52	NUAK1	0.62908703
53	CAMKK2	0.61386137
54	CAMK2G	0.58861998
55	MAP4K1	0.58003698
56	AKT2	0.55248991
57	EPHB2	0.54253568
58	PTK2B	0.53341931
59	ERBB2	0.53169109
60	MAP4K2	0.52118093
61	AURKA	0.51619546
62	RPS6KA5	0.50827704
63	KIT	0.50517008
64	TRPM7	0.49726103
65	KDR	0.49217036
66	IKBKB	0.48533530
67	EIF2AK2	0.48290375
68	PRKG2	0.47077682
69	CAMK2B	0.42826313
70	MAP2K1	0.42672136
71	FLT3	0.40142200
72	PRKCI	0.39868145
73	ROCK1	0.39641775
74	IGF1R	0.39286137
75	CDK9	0.39195612
76	EEF2K	0.37478634
77	TBK1	0.36355334
78	PRKCA	0.36024771
79	PDK1	0.35010471
80	MATK	0.34756510
81	LYN	0.34343636
82	YES1	0.34213259
83	DDR2	0.33860696
84	DAPK2	0.32993253
85	STK10	0.32896662
86	MAP2K6	0.32557434
87	PKN1	0.30626986
88	OBSCN	0.29306725
89	EGFR	0.28886089
90	RPS6KA4	0.28702142
91	CAMK2D	0.28545061
92	PRKCE	0.27836142
93	PRKCQ	0.27805602
94	CSK	0.27714866
95	MAPK11	0.27674783
96	JAK1	0.27395162
97	AURKB	0.27349818
98	BRSK1	0.27188106
99	CSF1R	0.26165548
100	CSNK1A1L	0.26035892

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.21377561
2	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.89869845
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.46364521
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.45695665
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.26839282
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.23543829
7	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.16070638
8	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.11776945
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.10112426
10	Asthma_Homo sapiens_hsa05310	2.09883894
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.08990200
12	Histidine metabolism_Homo sapiens_hsa00340	2.04001633
13	Proteasome_Homo sapiens_hsa03050	2.03005280
14	Tryptophan metabolism_Homo sapiens_hsa00380	2.01533652
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.99124917
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.96467918
17	Caffeine metabolism_Homo sapiens_hsa00232	1.94213460
18	Homologous recombination_Homo sapiens_hsa03440	1.93097460
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.90067496
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78626150
21	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.71161947
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67922671
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.63398444
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55847557
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.53420878
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.44045158
27	Pancreatic secretion_Homo sapiens_hsa04972	1.43017791
28	Sulfur metabolism_Homo sapiens_hsa00920	1.42403771
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38597335
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.38497693
31	Phototransduction_Homo sapiens_hsa04744	1.38428109
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.33594042
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.32713582
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.30849526
35	Protein digestion and absorption_Homo sapiens_hsa04974	1.29406657
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.29142095
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27081865
38	Lysosome_Homo sapiens_hsa04142	1.26601021
39	Allograft rejection_Homo sapiens_hsa05330	1.24828019
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.23947448
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.21044991
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.21043367
43	Vibrio cholerae infection_Homo sapiens_hsa05110	1.16255285
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.12499077
45	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07529134
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04468973
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04094391
48	Butanoate metabolism_Homo sapiens_hsa00650	1.04039352
49	Complement and coagulation cascades_Homo sapiens_hsa04610	1.03939928
50	Glutathione metabolism_Homo sapiens_hsa00480	1.01069498
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99001360
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96776112
53	Sulfur relay system_Homo sapiens_hsa04122	0.93077815
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89558714
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88453164
56	Fatty acid degradation_Homo sapiens_hsa00071	0.87900380
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.85420638
58	Tight junction_Homo sapiens_hsa04530	0.82646354
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82325174
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.81678817
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80419108
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.80307287
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79107685
64	Peroxisome_Homo sapiens_hsa04146	0.77115035
65	Phenylalanine metabolism_Homo sapiens_hsa00360	0.77002592
66	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76923254
67	Retinol metabolism_Homo sapiens_hsa00830	0.72618950
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.69119389
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.65649507
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64929322
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62313033
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.61925549
73	Bile secretion_Homo sapiens_hsa04976	0.61334774
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57204837
75	Influenza A_Homo sapiens_hsa05164	0.56925789
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56532993
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.56520798
78	Morphine addiction_Homo sapiens_hsa05032	0.54907546
79	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.52355205
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49793900
81	Folate biosynthesis_Homo sapiens_hsa00790	0.48451522
82	Galactose metabolism_Homo sapiens_hsa00052	0.48393323
83	Nicotine addiction_Homo sapiens_hsa05033	0.47395814
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.44201460
85	Metabolic pathways_Homo sapiens_hsa01100	0.43788638
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43719216
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43663080
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42753437
89	Base excision repair_Homo sapiens_hsa03410	0.42178478
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.41533505
91	Phagosome_Homo sapiens_hsa04145	0.40270684
92	ABC transporters_Homo sapiens_hsa02010	0.39858066
93	Fanconi anemia pathway_Homo sapiens_hsa03460	0.39555788
94	DNA replication_Homo sapiens_hsa03030	0.38976948
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.38122359
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37554090
97	Fatty acid elongation_Homo sapiens_hsa00062	0.36724530
98	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.33903430
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.33453560
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33452793

KRT8P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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