KRT8P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)6.31815252
2antibacterial humoral response (GO:0019731)6.17659956
3antimicrobial humoral response (GO:0019730)6.03298504
4positive regulation of pseudopodium assembly (GO:0031274)5.88609447
5positive regulation of respiratory burst (GO:0060267)5.74408896
6angiotensin maturation (GO:0002003)5.43760055
7regulation of cellular extravasation (GO:0002691)5.38732791
8regulation of pseudopodium assembly (GO:0031272)5.28224223
9fructose metabolic process (GO:0006000)5.17258693
10positive regulation of guanylate cyclase activity (GO:0031284)5.03405264
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01780502
12antigen processing and presentation of endogenous antigen (GO:0019883)4.90983327
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88356432
14NADH metabolic process (GO:0006734)4.82477310
15eosinophil chemotaxis (GO:0048245)4.63295123
16killing of cells of other organism (GO:0031640)4.35030351
17disruption of cells of other organism (GO:0044364)4.35030351
18fat-soluble vitamin biosynthetic process (GO:0042362)4.27724657
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20858679
20glomerular filtration (GO:0003094)4.17244969
21eosinophil migration (GO:0072677)4.13239102
22defense response to fungus (GO:0050832)4.08002443
23negative regulation of epidermal cell differentiation (GO:0045605)4.04427201
24GDP-mannose metabolic process (GO:0019673)4.01958206
25regulation of respiratory burst (GO:0060263)4.01025736
26regulation of cGMP biosynthetic process (GO:0030826)3.85567504
27renal filtration (GO:0097205)3.73461805
28diacylglycerol metabolic process (GO:0046339)3.70453605
29regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.61598861
30complement activation, classical pathway (GO:0006958)3.53524122
31detection of bacterium (GO:0016045)3.46512861
32detection of other organism (GO:0098543)3.46092627
33intestinal absorption (GO:0050892)3.34081338
34alkaloid metabolic process (GO:0009820)3.32302752
35chronic inflammatory response (GO:0002544)3.29345638
36vitamin A metabolic process (GO:0006776)3.25085965
37maintenance of gastrointestinal epithelium (GO:0030277)3.24121061
38glycolipid catabolic process (GO:0019377)3.19046156
39lipoprotein transport (GO:0042953)3.18658895
40regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17775697
41regulation of cGMP metabolic process (GO:0030823)3.17271837
42cytidine metabolic process (GO:0046087)3.17211859
43cytidine catabolic process (GO:0006216)3.17211859
44cytidine deamination (GO:0009972)3.17211859
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16728452
46negative regulation of cell killing (GO:0031342)3.16728452
47leukotriene metabolic process (GO:0006691)3.14900826
48cyclooxygenase pathway (GO:0019371)3.13108242
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.12935581
50nucleoside diphosphate biosynthetic process (GO:0009133)3.12257525
51response to fungus (GO:0009620)3.10959167
52epoxygenase P450 pathway (GO:0019373)3.08185177
53negative regulation of leukocyte chemotaxis (GO:0002689)3.04143051
54negative regulation of epidermis development (GO:0045683)3.02945942
55digestion (GO:0007586)3.00783239
56L-ascorbic acid metabolic process (GO:0019852)2.95517936
57positive regulation of glycoprotein biosynthetic process (GO:0010560)2.93550746
58positive regulation of cGMP biosynthetic process (GO:0030828)2.93414303
59cellular response to cadmium ion (GO:0071276)2.93251096
60urea cycle (GO:0000050)2.92308276
61oligosaccharide catabolic process (GO:0009313)2.90618924
62complement activation (GO:0006956)2.89363961
63immunoglobulin mediated immune response (GO:0016064)2.86695429
64vitamin transport (GO:0051180)2.86454465
65cellular response to zinc ion (GO:0071294)2.86136538
66calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.85163783
67glycosphingolipid catabolic process (GO:0046479)2.82771717
68T-helper 1 type immune response (GO:0042088)2.82464042
69negative regulation of leukocyte migration (GO:0002686)2.81302310
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80815049
71vitamin transmembrane transport (GO:0035461)2.80809613
72pyrimidine ribonucleoside catabolic process (GO:0046133)2.80226330
73sulfur amino acid catabolic process (GO:0000098)2.79260902
74receptor guanylyl cyclase signaling pathway (GO:0007168)2.79141300
75detection of external biotic stimulus (GO:0098581)2.78509630
76positive regulation of glycoprotein metabolic process (GO:1903020)2.76867213
77regulation of systemic arterial blood pressure by hormone (GO:0001990)2.76698343
78regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.76698343
79endocrine process (GO:0050886)2.76698343
80urea metabolic process (GO:0019627)2.74230865
81auditory receptor cell differentiation (GO:0042491)2.73171519
82regulation of triglyceride catabolic process (GO:0010896)2.69962812
83sulfation (GO:0051923)2.69430078
84phosphatidylinositol acyl-chain remodeling (GO:0036149)2.69282149
85peptide catabolic process (GO:0043171)2.68913226
86regulation of protein glycosylation (GO:0060049)2.66849324
87positive regulation of antigen processing and presentation (GO:0002579)2.66529260
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64084671
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.64084671
90modulation by symbiont of host immune response (GO:0052553)2.64084671
91positive regulation by symbiont of host defense response (GO:0052509)2.64084671
92modulation by symbiont of host defense response (GO:0052031)2.64084671
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64084671
94sphingolipid catabolic process (GO:0030149)2.63286601
95membrane lipid catabolic process (GO:0046466)2.62981897
96phosphatidylserine acyl-chain remodeling (GO:0036150)2.59744042
97drug metabolic process (GO:0017144)2.58731850
98transcytosis (GO:0045056)2.58729928
99fucosylation (GO:0036065)2.57730572
100phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.57680299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.52658715
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.40684892
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.83041479
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.82574864
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.59394671
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53657938
7LXR_22292898_ChIP-Seq_THP-1_Human2.30541192
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.29928928
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.23838231
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20756566
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12896452
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05142989
13RXR_22158963_ChIP-Seq_LIVER_Mouse1.87290213
14PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85320879
15BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.75357380
16VDR_21846776_ChIP-Seq_THP-1_Human1.72248772
17SA1_27219007_Chip-Seq_Bcells_Human1.68464060
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.67027430
19GATA4_25053715_ChIP-Seq_YYC3_Human1.66036682
20VDR_24763502_ChIP-Seq_THP-1_Human1.66016375
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62789342
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62759349
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62653921
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61284850
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61263319
26BCOR_27268052_Chip-Seq_Bcells_Human1.58480390
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55240083
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54208984
29BCL6_27268052_Chip-Seq_Bcells_Human1.52349283
30RACK7_27058665_Chip-Seq_MCF-7_Human1.52240238
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45588118
32SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45330736
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45192698
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44720871
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44466568
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44446884
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.43409528
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40533085
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37833238
40SOX2_20726797_ChIP-Seq_SW620_Human1.37657124
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36224352
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.35056390
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33878569
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.33477825
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.33184577
46GATA6_25053715_ChIP-Seq_YYC3_Human1.32232309
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31741144
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31289361
49STAT1_20625510_ChIP-Seq_HELA_Human1.30757815
50SPI1_23127762_ChIP-Seq_K562_Human1.30266373
51CTCF_27219007_Chip-Seq_Bcells_Human1.29849028
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27510708
53DROSHA_22980978_ChIP-Seq_HELA_Human1.26350744
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.26043859
55EGR1_19032775_ChIP-ChIP_M12_Human1.25171986
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24686019
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23199508
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22873759
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22289970
60CTCF_20526341_ChIP-Seq_ESCs_Human1.22052305
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20127122
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15224519
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.14763721
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.13953368
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13626107
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11934538
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11378002
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10054235
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09038904
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08916509
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08315142
72JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06935842
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.05897384
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05749107
75RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05613023
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04637410
77E2F1_20622854_ChIP-Seq_HELA_Human1.04511734
78TP63_22573176_ChIP-Seq_HFKS_Human1.03348011
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03146075
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01934283
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00990828
82P68_20966046_ChIP-Seq_HELA_Human1.00609351
83SPI1_23547873_ChIP-Seq_NB4_Human1.00058290
84SMC4_20622854_ChIP-Seq_HELA_Human0.99976807
85NANOG_20526341_ChIP-Seq_ESCs_Human0.99667392
86TCF7_22412390_ChIP-Seq_EML_Mouse0.98721277
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97728348
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95603227
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.95218715
90UTX_26944678_Chip-Seq_JUKART_Human0.92078921
91SOX2_21211035_ChIP-Seq_LN229_Human0.91941705
92SCL_19346495_ChIP-Seq_HPC-7_Human0.91564510
93STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91115397
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89802182
95P300_27268052_Chip-Seq_Bcells_Human0.88712183
96PHF8_20622854_ChIP-Seq_HELA_Human0.88646767
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.87615993
98MAF_26560356_Chip-Seq_TH1_Human0.87095881
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.86995956
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86703403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.31897016
2MP0001666_abnormal_nutrient_absorption3.77390376
3MP0010155_abnormal_intestine_physiology3.56337735
4MP0003724_increased_susceptibility_to3.20003429
5MP0002139_abnormal_hepatobiliary_system3.18531285
6MP0004019_abnormal_vitamin_homeostasis2.96184724
7MP0009379_abnormal_foot_pigmentation2.93808164
8MP0005085_abnormal_gallbladder_physiolo2.63883562
9MP0010234_abnormal_vibrissa_follicle2.34635318
10MP0003436_decreased_susceptibility_to2.32191703
11MP0003183_abnormal_peptide_metabolism2.23462131
12MP0009840_abnormal_foam_cell2.20331560
13MP0003879_abnormal_hair_cell2.10892105
14MP0005365_abnormal_bile_salt2.04960342
15MP0003303_peritoneal_inflammation2.04634460
16MP0004858_abnormal_nervous_system2.02112916
17MP0006082_CNS_inflammation1.98742753
18MP0003866_abnormal_defecation1.98502355
19MP0005166_decreased_susceptibility_to1.96333365
20MP0001835_abnormal_antigen_presentation1.92236079
21MP0001790_abnormal_immune_system1.88803266
22MP0005387_immune_system_phenotype1.88803266
23MP0000490_abnormal_crypts_of1.88244155
24MP0003191_abnormal_cellular_cholesterol1.87132878
25MP0005409_darkened_coat_color1.78561424
26MP0005645_abnormal_hypothalamus_physiol1.77569922
27MP0001664_abnormal_digestion1.75804432
28MP0005025_abnormal_response_to1.75432417
29MP0002876_abnormal_thyroid_physiology1.71156806
30MP0009785_altered_susceptibility_to1.69059982
31MP0008260_abnormal_autophagy1.66752548
32MP0010329_abnormal_lipoprotein_level1.65389247
33MP0002419_abnormal_innate_immunity1.58487779
34MP0000013_abnormal_adipose_tissue1.55879208
35MP0001533_abnormal_skeleton_physiology1.55853574
36MP0001845_abnormal_inflammatory_respons1.55157141
37MP0003806_abnormal_nucleotide_metabolis1.44146518
38MP0003075_altered_response_to1.43976454
39MP0002148_abnormal_hypersensitivity_rea1.43788812
40MP0005451_abnormal_body_composition1.43520541
41MP0010352_gastrointestinal_tract_polyps1.41459224
42MP0000678_abnormal_parathyroid_gland1.38374181
43MP0001663_abnormal_digestive_system1.37956952
44MP0009764_decreased_sensitivity_to1.32339836
45MP0001873_stomach_inflammation1.31436856
46MP0009643_abnormal_urine_homeostasis1.29301740
47MP0001765_abnormal_ion_homeostasis1.29238186
48MP0000477_abnormal_intestine_morphology1.27521160
49MP0000685_abnormal_immune_system1.26373075
50MP0005000_abnormal_immune_tolerance1.23646488
51MP0003329_amyloid_beta_deposits1.22440860
52MP0005174_abnormal_tail_pigmentation1.20405159
53MP0004264_abnormal_extraembryonic_tissu1.20269176
54MP0001800_abnormal_humoral_immune1.16975724
55MP0005058_abnormal_lysosome_morphology1.14326011
56MP0001819_abnormal_immune_cell1.13534354
57MP0005535_abnormal_body_temperature1.12947822
58MP0002420_abnormal_adaptive_immunity1.11698122
59MP0004147_increased_porphyrin_level1.09834571
60MP0000538_abnormal_urinary_bladder1.08243559
61MP0001756_abnormal_urination1.07834031
62MP0002118_abnormal_lipid_homeostasis1.07616568
63MP0001501_abnormal_sleep_pattern1.04998458
64MP0005381_digestive/alimentary_phenotyp1.04315447
65MP0002796_impaired_skin_barrier1.04190873
66MP0002723_abnormal_immune_serum1.03970431
67MP0002452_abnormal_antigen_presenting1.02930664
68MP0000465_gastrointestinal_hemorrhage1.01894196
69MP0005332_abnormal_amino_acid1.00435512
70MP0002136_abnormal_kidney_physiology0.98228409
71MP0003718_maternal_effect0.98175840
72MP0005671_abnormal_response_to0.98129357
73MP0002166_altered_tumor_susceptibility0.97952143
74MP0008469_abnormal_protein_level0.96552110
75MP0003252_abnormal_bile_duct0.93599778
76MP0000681_abnormal_thyroid_gland0.93477093
77MP0000604_amyloidosis0.92993324
78MP0008004_abnormal_stomach_pH0.91066629
79MP0005464_abnormal_platelet_physiology0.89917356
80MP0002998_abnormal_bone_remodeling0.85686618
81MP0002396_abnormal_hematopoietic_system0.83937057
82MP0004782_abnormal_surfactant_physiolog0.82809516
83MP0001764_abnormal_homeostasis0.80944714
84MP0005448_abnormal_energy_balance0.80741234
85MP0005319_abnormal_enzyme/_coenzyme0.80432682
86MP0005165_increased_susceptibility_to0.79930684
87MP0003045_fibrosis0.79746789
88MP0009278_abnormal_bone_marrow0.78885007
89MP0009780_abnormal_chondrocyte_physiolo0.77718301
90MP0000462_abnormal_digestive_system0.77141752
91MP0005310_abnormal_salivary_gland0.76746080
92MP0002971_abnormal_brown_adipose0.76572340
93MP0005584_abnormal_enzyme/coenzyme_acti0.76242567
94MP0003638_abnormal_response/metabolism_0.73004755
95MP0004947_skin_inflammation0.72534565
96MP0005636_abnormal_mineral_homeostasis0.72304127
97MP0004484_altered_response_of0.70180910
98MP0000716_abnormal_immune_system0.68985695
99MP0002277_abnormal_respiratory_mucosa0.68566621
100MP0004270_analgesia0.67851917

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)6.77076912
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.57071045
3Systemic lupus erythematosus (HP:0002725)5.04449215
4Eczematoid dermatitis (HP:0000976)4.17378607
5Recurrent bacterial skin infections (HP:0005406)3.80428679
6Recurrent abscess formation (HP:0002722)3.76327785
7Abnormality of proline metabolism (HP:0010907)3.69707552
8Hydroxyprolinuria (HP:0003080)3.69707552
9Myositis (HP:0100614)3.68092093
10Chronic otitis media (HP:0000389)3.41346504
11Proximal tubulopathy (HP:0000114)3.32866019
12Orchitis (HP:0100796)3.30755670
13Elevated erythrocyte sedimentation rate (HP:0003565)3.27531309
14Nausea (HP:0002018)3.26868452
15Abnormality of macrophages (HP:0004311)3.09106132
16Glomerulonephritis (HP:0000099)3.08026826
17Confusion (HP:0001289)2.98961821
18Chronic diarrhea (HP:0002028)2.89288082
19Abnormality of the vitamin B12 metabolism (HP:0004341)2.79550783
20Abnormality of complement system (HP:0005339)2.76476081
21Abnormality of vitamin B metabolism (HP:0004340)2.74108981
22Pustule (HP:0200039)2.73910678
23Stridor (HP:0010307)2.67675345
24Gastrointestinal infarctions (HP:0005244)2.65562910
25Congenital sensorineural hearing impairment (HP:0008527)2.64907569
26Muscle fibrillation (HP:0010546)2.62659637
27Meningitis (HP:0001287)2.60290754
28Absent/shortened dynein arms (HP:0200106)2.58800952
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.58800952
30Abnormality of urine glucose concentration (HP:0011016)2.57814969
31Glycosuria (HP:0003076)2.57814969
32Amyloidosis (HP:0011034)2.56678203
33Obstructive lung disease (HP:0006536)2.55044542
34Chronic obstructive pulmonary disease (HP:0006510)2.55044542
35Ankle clonus (HP:0011448)2.54662507
36Nephritis (HP:0000123)2.52237100
37Posterior subcapsular cataract (HP:0007787)2.51750587
38Retrobulbar optic neuritis (HP:0100654)2.50381270
39Optic neuritis (HP:0100653)2.50381270
40Abnormality of purine metabolism (HP:0004352)2.47740520
41Alkalosis (HP:0001948)2.46013807
42Gingivitis (HP:0000230)2.45787250
43Complement deficiency (HP:0004431)2.42026372
44Loss of speech (HP:0002371)2.41652220
45Cellulitis (HP:0100658)2.41530556
46Recurrent skin infections (HP:0001581)2.39807985
47Hypobetalipoproteinemia (HP:0003563)2.38064858
48Metabolic alkalosis (HP:0200114)2.37998099
49Increased CSF protein (HP:0002922)2.37405185
50Petechiae (HP:0000967)2.36676170
51Encephalitis (HP:0002383)2.34660386
52Tongue fasciculations (HP:0001308)2.34593342
53Widely patent fontanelles and sutures (HP:0004492)2.32696198
54Myopathic facies (HP:0002058)2.27885660
55Fat malabsorption (HP:0002630)2.26647158
56Decreased circulating renin level (HP:0003351)2.26447068
57Hypophosphatemia (HP:0002148)2.26081572
58Recurrent gram-negative bacterial infections (HP:0005420)2.24618422
59Recurrent sinusitis (HP:0011108)2.23300429
60Abnormality of the nasal mucosa (HP:0000433)2.22921994
61Hemoptysis (HP:0002105)2.22337703
62Abnormality of nucleobase metabolism (HP:0010932)2.22040512
63Vasculitis (HP:0002633)2.20482888
64Nasal polyposis (HP:0100582)2.19618666
65Increased IgE level (HP:0003212)2.17526788
66Increased purine levels (HP:0004368)2.17397219
67Hyperuricemia (HP:0002149)2.17397219
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.15117493
69Xanthomatosis (HP:0000991)2.14331742
70Recurrent fungal infections (HP:0002841)2.12469323
71Prolonged partial thromboplastin time (HP:0003645)2.11955380
72Abnormality of vitamin metabolism (HP:0100508)2.08775736
73Mediastinal lymphadenopathy (HP:0100721)2.06914579
74Agammaglobulinemia (HP:0004432)2.05822689
75Pancreatitis (HP:0001733)2.05161756
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04645426
77Skin rash (HP:0000988)2.04237636
78Keratoconjunctivitis sicca (HP:0001097)2.03425891
79Ileus (HP:0002595)2.03395200
80Pigmentary retinal degeneration (HP:0001146)2.02562272
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02138550
82Dicarboxylic aciduria (HP:0003215)2.02138550
83Hyperphosphaturia (HP:0003109)2.01137166
84Hemiplegia (HP:0002301)2.00868570
85Urticaria (HP:0001025)2.00416572
86Growth hormone excess (HP:0000845)2.00021632
87Premature loss of primary teeth (HP:0006323)1.96613943
88Abnormal hair laboratory examination (HP:0003328)1.96471523
89Abnormal urine phosphate concentration (HP:0012599)1.92876531
90Vacuolated lymphocytes (HP:0001922)1.92766530
91Pulmonary infiltrates (HP:0002113)1.92342325
92Peritonitis (HP:0002586)1.89610784
93Increased cerebral lipofuscin (HP:0011813)1.89263776
94Steatorrhea (HP:0002570)1.88325182
95Polygenic inheritance (HP:0010982)1.87443055
96Thin bony cortex (HP:0002753)1.86979752
97Increased neuronal autofluorescent lipopigment (HP:0002074)1.86623063
98Paresthesia (HP:0003401)1.85380521
99Abnormal albumin level (HP:0012116)1.84584154
100Hypoalbuminemia (HP:0003073)1.84584154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.80356113
2ERN14.79432121
3RIPK42.96886712
4STK242.45458705
5TYK22.31161083
6PRKG22.26746429
7GRK62.18190629
8PRKD32.16279099
9EPHB12.11593765
10PTK62.03669189
11MAP4K11.99808616
12MAP3K111.79588972
13EPHA41.76742229
14IRAK41.75534025
15MAP3K121.71644319
16BLK1.71154185
17TESK21.68800956
18DAPK21.63169826
19KIT1.59228478
20TNK21.59186045
21ZAP701.55648506
22EPHA21.49854592
23MAP2K21.49074533
24FGFR41.48212791
25RIPK11.45684411
26TBK11.43264738
27MAP3K11.41783781
28EPHA31.32066906
29BTK1.24289930
30MYLK1.23837713
31TAOK11.21677277
32STK161.21644408
33MST1R1.19350456
34PRKD21.15656818
35GRK11.15439014
36CSK1.14889304
37SIK31.12495249
38SYK1.12352476
39JAK21.09193344
40PDPK11.08279425
41MAP2K30.97630099
42KSR20.96482989
43EPHB20.96229967
44PRPF4B0.93712548
45MAP2K60.93290434
46CDK190.93002066
47JAK30.92547487
48IRAK10.91884002
49IKBKE0.91692300
50ITK0.90150331
51FES0.88876830
52TEC0.87727207
53ILK0.87691740
54MAP3K20.87182574
55PRKCZ0.85353406
56OXSR10.84897390
57LYN0.83824381
58MAP3K30.78489733
59ABL20.74956403
60MATK0.74876060
61HCK0.74422426
62JAK10.72887904
63SMG10.72568327
64MAPKAPK30.72151903
65BMX0.71281121
66DDR20.68809099
67TRIB30.67524204
68TESK10.65371200
69FGFR30.65095344
70TXK0.62692737
71PDK10.61623994
72PRKCQ0.61451808
73SIK10.61188499
74ERBB20.58660208
75LCK0.57968992
76PAK60.57820586
77ADRBK20.56530735
78DAPK10.55255907
79FER0.54940045
80LRRK20.54454942
81PRKCA0.52508032
82FGR0.50529786
83SRC0.49543535
84BMPR20.49038746
85RPS6KA20.46683097
86CSF1R0.46421849
87CDC42BPA0.46392322
88ADRBK10.44898611
89DYRK1B0.44726435
90HIPK20.43447820
91PRKCD0.42912391
92PAK40.42876088
93PTK2B0.42659046
94RPS6KL10.42591927
95RPS6KC10.42591927
96PRKACG0.42112698
97TAOK20.41540359
98TNIK0.38885363
99RPS6KA60.38345479
100FYN0.38333375

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.13155965
2Fat digestion and absorption_Homo sapiens_hsa049753.77907375
3Vitamin digestion and absorption_Homo sapiens_hsa049773.56335435
4Sulfur metabolism_Homo sapiens_hsa009203.14056196
5Fructose and mannose metabolism_Homo sapiens_hsa000512.73574526
6Asthma_Homo sapiens_hsa053102.53690486
7Arginine biosynthesis_Homo sapiens_hsa002202.32213391
8Staphylococcus aureus infection_Homo sapiens_hsa051502.23974993
9Renin-angiotensin system_Homo sapiens_hsa046142.13079731
10Mineral absorption_Homo sapiens_hsa049781.99787414
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.88137216
12Allograft rejection_Homo sapiens_hsa053301.84414147
13Protein digestion and absorption_Homo sapiens_hsa049741.82866967
14Autoimmune thyroid disease_Homo sapiens_hsa053201.78496768
15Arachidonic acid metabolism_Homo sapiens_hsa005901.71989301
16Graft-versus-host disease_Homo sapiens_hsa053321.71001040
17Histidine metabolism_Homo sapiens_hsa003401.66167198
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64659473
19Chemical carcinogenesis_Homo sapiens_hsa052041.57637671
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55540001
21Leishmaniasis_Homo sapiens_hsa051401.49149887
22Linoleic acid metabolism_Homo sapiens_hsa005911.47528074
23Type I diabetes mellitus_Homo sapiens_hsa049401.47525350
24Glycerolipid metabolism_Homo sapiens_hsa005611.46728350
25Glutathione metabolism_Homo sapiens_hsa004801.36666983
26Other glycan degradation_Homo sapiens_hsa005111.30457264
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26015434
28Bile secretion_Homo sapiens_hsa049761.25825954
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25111411
30Caffeine metabolism_Homo sapiens_hsa002321.23999050
31Pancreatic secretion_Homo sapiens_hsa049721.20770424
32PPAR signaling pathway_Homo sapiens_hsa033201.18615747
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10373896
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09800312
35Antigen processing and presentation_Homo sapiens_hsa046121.07310978
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02758912
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94025767
38Ether lipid metabolism_Homo sapiens_hsa005650.89495838
39Tuberculosis_Homo sapiens_hsa051520.87899671
40Fatty acid degradation_Homo sapiens_hsa000710.84828339
41Starch and sucrose metabolism_Homo sapiens_hsa005000.83018605
42Chemokine signaling pathway_Homo sapiens_hsa040620.82806643
43Retinol metabolism_Homo sapiens_hsa008300.81759977
44Pentose phosphate pathway_Homo sapiens_hsa000300.80722561
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79805320
46Arginine and proline metabolism_Homo sapiens_hsa003300.78925814
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78448666
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76625646
49Sulfur relay system_Homo sapiens_hsa041220.76384086
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.74879609
51Galactose metabolism_Homo sapiens_hsa000520.74738590
52Pertussis_Homo sapiens_hsa051330.73692196
53Osteoclast differentiation_Homo sapiens_hsa043800.72821630
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.72623858
55Viral myocarditis_Homo sapiens_hsa054160.68457314
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66731003
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64216951
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62571043
59Phagosome_Homo sapiens_hsa041450.61266167
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60045756
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.58882054
62Hepatitis C_Homo sapiens_hsa051600.57494809
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55955807
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53056010
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52319052
66Hematopoietic cell lineage_Homo sapiens_hsa046400.51650103
67Sphingolipid metabolism_Homo sapiens_hsa006000.50159851
68Toxoplasmosis_Homo sapiens_hsa051450.50098535
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.47585262
70Rheumatoid arthritis_Homo sapiens_hsa053230.46983109
71Thyroid hormone synthesis_Homo sapiens_hsa049180.45789429
72Influenza A_Homo sapiens_hsa051640.45754438
73Complement and coagulation cascades_Homo sapiens_hsa046100.45752845
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44513266
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43420620
76Prion diseases_Homo sapiens_hsa050200.42191122
77Insulin secretion_Homo sapiens_hsa049110.40520797
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40361975
79African trypanosomiasis_Homo sapiens_hsa051430.37823116
80Primary immunodeficiency_Homo sapiens_hsa053400.36913536
81Tryptophan metabolism_Homo sapiens_hsa003800.35570826
82Lysosome_Homo sapiens_hsa041420.33279988
83GnRH signaling pathway_Homo sapiens_hsa049120.32176828
84Fatty acid metabolism_Homo sapiens_hsa012120.31767212
85Renin secretion_Homo sapiens_hsa049240.31329952
86Regulation of autophagy_Homo sapiens_hsa041400.30450228
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29983569
88Phenylalanine metabolism_Homo sapiens_hsa003600.29628900
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28697099
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26580136
91B cell receptor signaling pathway_Homo sapiens_hsa046620.25876621
92Amoebiasis_Homo sapiens_hsa051460.25847773
93Salmonella infection_Homo sapiens_hsa051320.25805358
94Peroxisome_Homo sapiens_hsa041460.25384412
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.24696868
96Salivary secretion_Homo sapiens_hsa049700.24519062
97Endocytosis_Homo sapiens_hsa041440.23616294
98Folate biosynthesis_Homo sapiens_hsa007900.23073568
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.22431674
100Ovarian steroidogenesis_Homo sapiens_hsa049130.22253133

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