ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of guanylate cyclase activity (GO:0031282)	6.31815252
2	antibacterial humoral response (GO:0019731)	6.17659956
3	antimicrobial humoral response (GO:0019730)	6.03298504
4	positive regulation of pseudopodium assembly (GO:0031274)	5.88609447
5	positive regulation of respiratory burst (GO:0060267)	5.74408896
6	angiotensin maturation (GO:0002003)	5.43760055
7	regulation of cellular extravasation (GO:0002691)	5.38732791
8	regulation of pseudopodium assembly (GO:0031272)	5.28224223
9	fructose metabolic process (GO:0006000)	5.17258693
10	positive regulation of guanylate cyclase activity (GO:0031284)	5.03405264
11	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	5.01780502
12	antigen processing and presentation of endogenous antigen (GO:0019883)	4.90983327
13	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	4.88356432
14	NADH metabolic process (GO:0006734)	4.82477310
15	eosinophil chemotaxis (GO:0048245)	4.63295123
16	disruption of cells of other organism (GO:0044364)	4.35030351
17	killing of cells of other organism (GO:0031640)	4.35030351
18	fat-soluble vitamin biosynthetic process (GO:0042362)	4.27724657
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.20858679
20	glomerular filtration (GO:0003094)	4.17244969
21	eosinophil migration (GO:0072677)	4.13239102
22	defense response to fungus (GO:0050832)	4.08002443
23	negative regulation of epidermal cell differentiation (GO:0045605)	4.04427201
24	GDP-mannose metabolic process (GO:0019673)	4.01958206
25	regulation of respiratory burst (GO:0060263)	4.01025736
26	regulation of cGMP biosynthetic process (GO:0030826)	3.85567504
27	renal filtration (GO:0097205)	3.73461805
28	diacylglycerol metabolic process (GO:0046339)	3.70453605
29	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.61598861
30	complement activation, classical pathway (GO:0006958)	3.53524122
31	detection of bacterium (GO:0016045)	3.46512861
32	detection of other organism (GO:0098543)	3.46092627
33	intestinal absorption (GO:0050892)	3.34081338
34	alkaloid metabolic process (GO:0009820)	3.32302752
35	chronic inflammatory response (GO:0002544)	3.29345638
36	vitamin A metabolic process (GO:0006776)	3.25085965
37	maintenance of gastrointestinal epithelium (GO:0030277)	3.24121061
38	glycolipid catabolic process (GO:0019377)	3.19046156
39	lipoprotein transport (GO:0042953)	3.18658895
40	regulation of dendritic cell antigen processing and presentation (GO:0002604)	3.17775697
41	regulation of cGMP metabolic process (GO:0030823)	3.17271837
42	cytidine metabolic process (GO:0046087)	3.17211859
43	cytidine catabolic process (GO:0006216)	3.17211859
44	cytidine deamination (GO:0009972)	3.17211859
45	negative regulation of cell killing (GO:0031342)	3.16728452
46	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.16728452
47	leukotriene metabolic process (GO:0006691)	3.14900826
48	cyclooxygenase pathway (GO:0019371)	3.13108242
49	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.12935581
50	nucleoside diphosphate biosynthetic process (GO:0009133)	3.12257525
51	response to fungus (GO:0009620)	3.10959167
52	epoxygenase P450 pathway (GO:0019373)	3.08185177
53	negative regulation of leukocyte chemotaxis (GO:0002689)	3.04143051
54	negative regulation of epidermis development (GO:0045683)	3.02945942
55	digestion (GO:0007586)	3.00783239
56	L-ascorbic acid metabolic process (GO:0019852)	2.95517936
57	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.93550746
58	positive regulation of cGMP biosynthetic process (GO:0030828)	2.93414303
59	cellular response to cadmium ion (GO:0071276)	2.93251096
60	urea cycle (GO:0000050)	2.92308276
61	oligosaccharide catabolic process (GO:0009313)	2.90618924
62	complement activation (GO:0006956)	2.89363961
63	immunoglobulin mediated immune response (GO:0016064)	2.86695429
64	vitamin transport (GO:0051180)	2.86454465
65	cellular response to zinc ion (GO:0071294)	2.86136538
66	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.85163783
67	glycosphingolipid catabolic process (GO:0046479)	2.82771717
68	T-helper 1 type immune response (GO:0042088)	2.82464042
69	negative regulation of leukocyte migration (GO:0002686)	2.81302310
70	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.80815049
71	vitamin transmembrane transport (GO:0035461)	2.80809613
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.80226330
73	sulfur amino acid catabolic process (GO:0000098)	2.79260902
74	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.79141300
75	detection of external biotic stimulus (GO:0098581)	2.78509630
76	positive regulation of glycoprotein metabolic process (GO:1903020)	2.76867213
77	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.76698343
78	endocrine process (GO:0050886)	2.76698343
79	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.76698343
80	urea metabolic process (GO:0019627)	2.74230865
81	auditory receptor cell differentiation (GO:0042491)	2.73171519
82	regulation of triglyceride catabolic process (GO:0010896)	2.69962812
83	sulfation (GO:0051923)	2.69430078
84	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.69282149
85	peptide catabolic process (GO:0043171)	2.68913226
86	regulation of protein glycosylation (GO:0060049)	2.66849324
87	positive regulation of antigen processing and presentation (GO:0002579)	2.66529260
88	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.64084671
89	modulation by symbiont of host immune response (GO:0052553)	2.64084671
90	positive regulation by symbiont of host defense response (GO:0052509)	2.64084671
91	modulation by symbiont of host defense response (GO:0052031)	2.64084671
92	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.64084671
93	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.64084671
94	sphingolipid catabolic process (GO:0030149)	2.63286601
95	membrane lipid catabolic process (GO:0046466)	2.62981897
96	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.59744042
97	drug metabolic process (GO:0017144)	2.58731850
98	transcytosis (GO:0045056)	2.58729928
99	fucosylation (GO:0036065)	2.57730572
100	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.57680299

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.52658715
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.40684892
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.83041479
4	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.82574864
5	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.59394671
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.53657938
7	LXR_22292898_ChIP-Seq_THP-1_Human	2.30541192
8	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.29928928
9	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.23838231
10	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.20756566
11	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.12896452
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.05142989
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.87290213
14	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.85320879
15	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.75357380
16	VDR_21846776_ChIP-Seq_THP-1_Human	1.72248772
17	SA1_27219007_Chip-Seq_Bcells_Human	1.68464060
18	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.67027430
19	GATA4_25053715_ChIP-Seq_YYC3_Human	1.66036682
20	VDR_24763502_ChIP-Seq_THP-1_Human	1.66016375
21	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.62789342
22	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.62759349
23	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.62653921
24	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.61284850
25	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.61263319
26	BCOR_27268052_Chip-Seq_Bcells_Human	1.58480390
27	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.55240083
28	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.54208984
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.52349283
30	RACK7_27058665_Chip-Seq_MCF-7_Human	1.52240238
31	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.45588118
32	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.45330736
33	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.45192698
34	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.44720871
35	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.44466568
36	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.44446884
37	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.43409528
38	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.40533085
39	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.37833238
40	SOX2_20726797_ChIP-Seq_SW620_Human	1.37657124
41	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.36224352
42	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.35056390
43	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.33878569
44	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.33477825
45	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.33184577
46	GATA6_25053715_ChIP-Seq_YYC3_Human	1.32232309
47	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.31741144
48	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.31289361
49	STAT1_20625510_ChIP-Seq_HELA_Human	1.30757815
50	SPI1_23127762_ChIP-Seq_K562_Human	1.30266373
51	CTCF_27219007_Chip-Seq_Bcells_Human	1.29849028
52	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.27510708
53	DROSHA_22980978_ChIP-Seq_HELA_Human	1.26350744
54	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.26043859
55	EGR1_19032775_ChIP-ChIP_M12_Human	1.25171986
56	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.24686019
57	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.23199508
58	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.22873759
59	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.22289970
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.22052305
61	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.20127122
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15224519
63	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.14763721
64	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.13953368
65	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13626107
66	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11934538
67	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.11378002
68	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.10054235
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09038904
70	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.08916509
71	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.08315142
72	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.06935842
73	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.05897384
74	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.05749107
75	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.05613023
76	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.04637410
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.04511734
78	TP63_22573176_ChIP-Seq_HFKS_Human	1.03348011
79	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.03146075
80	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.01934283
81	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.00990828
82	P68_20966046_ChIP-Seq_HELA_Human	1.00609351
83	SPI1_23547873_ChIP-Seq_NB4_Human	1.00058290
84	SMC4_20622854_ChIP-Seq_HELA_Human	0.99976807
85	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99667392
86	TCF7_22412390_ChIP-Seq_EML_Mouse	0.98721277
87	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97728348
88	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.95603227
89	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.95218715
90	UTX_26944678_Chip-Seq_JUKART_Human	0.92078921
91	SOX2_21211035_ChIP-Seq_LN229_Human	0.91941705
92	SCL_19346495_ChIP-Seq_HPC-7_Human	0.91564510
93	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.91115397
94	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89802182
95	P300_27268052_Chip-Seq_Bcells_Human	0.88712183
96	PHF8_20622854_ChIP-Seq_HELA_Human	0.88646767
97	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.87615993
98	MAF_26560356_Chip-Seq_TH1_Human	0.87095881
99	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.86995956
100	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.86703403

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.31897016
2	MP0001666_abnormal_nutrient_absorption	3.77390376
3	MP0010155_abnormal_intestine_physiology	3.56337735
4	MP0003724_increased_susceptibility_to	3.20003429
5	MP0002139_abnormal_hepatobiliary_system	3.18531285
6	MP0004019_abnormal_vitamin_homeostasis	2.96184724
7	MP0009379_abnormal_foot_pigmentation	2.93808164
8	MP0005085_abnormal_gallbladder_physiolo	2.63883562
9	MP0010234_abnormal_vibrissa_follicle	2.34635318
10	MP0003436_decreased_susceptibility_to	2.32191703
11	MP0003183_abnormal_peptide_metabolism	2.23462131
12	MP0009840_abnormal_foam_cell	2.20331560
13	MP0003879_abnormal_hair_cell	2.10892105
14	MP0005365_abnormal_bile_salt	2.04960342
15	MP0003303_peritoneal_inflammation	2.04634460
16	MP0004858_abnormal_nervous_system	2.02112916
17	MP0006082_CNS_inflammation	1.98742753
18	MP0003866_abnormal_defecation	1.98502355
19	MP0005166_decreased_susceptibility_to	1.96333365
20	MP0001835_abnormal_antigen_presentation	1.92236079
21	MP0005387_immune_system_phenotype	1.88803266
22	MP0001790_abnormal_immune_system	1.88803266
23	MP0000490_abnormal_crypts_of	1.88244155
24	MP0003191_abnormal_cellular_cholesterol	1.87132878
25	MP0005409_darkened_coat_color	1.78561424
26	MP0005645_abnormal_hypothalamus_physiol	1.77569922
27	MP0001664_abnormal_digestion	1.75804432
28	MP0005025_abnormal_response_to	1.75432417
29	MP0002876_abnormal_thyroid_physiology	1.71156806
30	MP0009785_altered_susceptibility_to	1.69059982
31	MP0008260_abnormal_autophagy	1.66752548
32	MP0010329_abnormal_lipoprotein_level	1.65389247
33	MP0002419_abnormal_innate_immunity	1.58487779
34	MP0000013_abnormal_adipose_tissue	1.55879208
35	MP0001533_abnormal_skeleton_physiology	1.55853574
36	MP0001845_abnormal_inflammatory_respons	1.55157141
37	MP0003806_abnormal_nucleotide_metabolis	1.44146518
38	MP0003075_altered_response_to	1.43976454
39	MP0002148_abnormal_hypersensitivity_rea	1.43788812
40	MP0005451_abnormal_body_composition	1.43520541
41	MP0010352_gastrointestinal_tract_polyps	1.41459224
42	MP0000678_abnormal_parathyroid_gland	1.38374181
43	MP0001663_abnormal_digestive_system	1.37956952
44	MP0009764_decreased_sensitivity_to	1.32339836
45	MP0001873_stomach_inflammation	1.31436856
46	MP0009643_abnormal_urine_homeostasis	1.29301740
47	MP0001765_abnormal_ion_homeostasis	1.29238186
48	MP0000477_abnormal_intestine_morphology	1.27521160
49	MP0000685_abnormal_immune_system	1.26373075
50	MP0005000_abnormal_immune_tolerance	1.23646488
51	MP0003329_amyloid_beta_deposits	1.22440860
52	MP0005174_abnormal_tail_pigmentation	1.20405159
53	MP0004264_abnormal_extraembryonic_tissu	1.20269176
54	MP0001800_abnormal_humoral_immune	1.16975724
55	MP0005058_abnormal_lysosome_morphology	1.14326011
56	MP0001819_abnormal_immune_cell	1.13534354
57	MP0005535_abnormal_body_temperature	1.12947822
58	MP0002420_abnormal_adaptive_immunity	1.11698122
59	MP0004147_increased_porphyrin_level	1.09834571
60	MP0000538_abnormal_urinary_bladder	1.08243559
61	MP0001756_abnormal_urination	1.07834031
62	MP0002118_abnormal_lipid_homeostasis	1.07616568
63	MP0001501_abnormal_sleep_pattern	1.04998458
64	MP0005381_digestive/alimentary_phenotyp	1.04315447
65	MP0002796_impaired_skin_barrier	1.04190873
66	MP0002723_abnormal_immune_serum	1.03970431
67	MP0002452_abnormal_antigen_presenting	1.02930664
68	MP0000465_gastrointestinal_hemorrhage	1.01894196
69	MP0005332_abnormal_amino_acid	1.00435512
70	MP0002136_abnormal_kidney_physiology	0.98228409
71	MP0003718_maternal_effect	0.98175840
72	MP0005671_abnormal_response_to	0.98129357
73	MP0002166_altered_tumor_susceptibility	0.97952143
74	MP0008469_abnormal_protein_level	0.96552110
75	MP0003252_abnormal_bile_duct	0.93599778
76	MP0000681_abnormal_thyroid_gland	0.93477093
77	MP0000604_amyloidosis	0.92993324
78	MP0008004_abnormal_stomach_pH	0.91066629
79	MP0005464_abnormal_platelet_physiology	0.89917356
80	MP0002998_abnormal_bone_remodeling	0.85686618
81	MP0002396_abnormal_hematopoietic_system	0.83937057
82	MP0004782_abnormal_surfactant_physiolog	0.82809516
83	MP0001764_abnormal_homeostasis	0.80944714
84	MP0005448_abnormal_energy_balance	0.80741234
85	MP0005319_abnormal_enzyme/_coenzyme	0.80432682
86	MP0005165_increased_susceptibility_to	0.79930684
87	MP0003045_fibrosis	0.79746789
88	MP0009278_abnormal_bone_marrow	0.78885007
89	MP0009780_abnormal_chondrocyte_physiolo	0.77718301
90	MP0000462_abnormal_digestive_system	0.77141752
91	MP0005310_abnormal_salivary_gland	0.76746080
92	MP0002971_abnormal_brown_adipose	0.76572340
93	MP0005584_abnormal_enzyme/coenzyme_acti	0.76242567
94	MP0003638_abnormal_response/metabolism_	0.73004755
95	MP0004947_skin_inflammation	0.72534565
96	MP0005636_abnormal_mineral_homeostasis	0.72304127
97	MP0004484_altered_response_of	0.70180910
98	MP0000716_abnormal_immune_system	0.68985695
99	MP0002277_abnormal_respiratory_mucosa	0.68566621
100	MP0004270_analgesia	0.67851917

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Malnutrition (HP:0004395)	6.77076912
2	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.57071045
3	Systemic lupus erythematosus (HP:0002725)	5.04449215
4	Eczematoid dermatitis (HP:0000976)	4.17378607
5	Recurrent bacterial skin infections (HP:0005406)	3.80428679
6	Recurrent abscess formation (HP:0002722)	3.76327785
7	Abnormality of proline metabolism (HP:0010907)	3.69707552
8	Hydroxyprolinuria (HP:0003080)	3.69707552
9	Myositis (HP:0100614)	3.68092093
10	Chronic otitis media (HP:0000389)	3.41346504
11	Proximal tubulopathy (HP:0000114)	3.32866019
12	Orchitis (HP:0100796)	3.30755670
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.27531309
14	Nausea (HP:0002018)	3.26868452
15	Abnormality of macrophages (HP:0004311)	3.09106132
16	Glomerulonephritis (HP:0000099)	3.08026826
17	Confusion (HP:0001289)	2.98961821
18	Chronic diarrhea (HP:0002028)	2.89288082
19	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.79550783
20	Abnormality of complement system (HP:0005339)	2.76476081
21	Abnormality of vitamin B metabolism (HP:0004340)	2.74108981
22	Pustule (HP:0200039)	2.73910678
23	Stridor (HP:0010307)	2.67675345
24	Gastrointestinal infarctions (HP:0005244)	2.65562910
25	Congenital sensorineural hearing impairment (HP:0008527)	2.64907569
26	Muscle fibrillation (HP:0010546)	2.62659637
27	Meningitis (HP:0001287)	2.60290754
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.58800952
29	Absent/shortened dynein arms (HP:0200106)	2.58800952
30	Glycosuria (HP:0003076)	2.57814969
31	Abnormality of urine glucose concentration (HP:0011016)	2.57814969
32	Amyloidosis (HP:0011034)	2.56678203
33	Chronic obstructive pulmonary disease (HP:0006510)	2.55044542
34	Obstructive lung disease (HP:0006536)	2.55044542
35	Ankle clonus (HP:0011448)	2.54662507
36	Nephritis (HP:0000123)	2.52237100
37	Posterior subcapsular cataract (HP:0007787)	2.51750587
38	Retrobulbar optic neuritis (HP:0100654)	2.50381270
39	Optic neuritis (HP:0100653)	2.50381270
40	Abnormality of purine metabolism (HP:0004352)	2.47740520
41	Alkalosis (HP:0001948)	2.46013807
42	Gingivitis (HP:0000230)	2.45787250
43	Complement deficiency (HP:0004431)	2.42026372
44	Loss of speech (HP:0002371)	2.41652220
45	Cellulitis (HP:0100658)	2.41530556
46	Recurrent skin infections (HP:0001581)	2.39807985
47	Hypobetalipoproteinemia (HP:0003563)	2.38064858
48	Metabolic alkalosis (HP:0200114)	2.37998099
49	Increased CSF protein (HP:0002922)	2.37405185
50	Petechiae (HP:0000967)	2.36676170
51	Encephalitis (HP:0002383)	2.34660386
52	Tongue fasciculations (HP:0001308)	2.34593342
53	Widely patent fontanelles and sutures (HP:0004492)	2.32696198
54	Myopathic facies (HP:0002058)	2.27885660
55	Fat malabsorption (HP:0002630)	2.26647158
56	Decreased circulating renin level (HP:0003351)	2.26447068
57	Hypophosphatemia (HP:0002148)	2.26081572
58	Recurrent gram-negative bacterial infections (HP:0005420)	2.24618422
59	Recurrent sinusitis (HP:0011108)	2.23300429
60	Abnormality of the nasal mucosa (HP:0000433)	2.22921994
61	Hemoptysis (HP:0002105)	2.22337703
62	Abnormality of nucleobase metabolism (HP:0010932)	2.22040512
63	Vasculitis (HP:0002633)	2.20482888
64	Nasal polyposis (HP:0100582)	2.19618666
65	Increased IgE level (HP:0003212)	2.17526788
66	Increased purine levels (HP:0004368)	2.17397219
67	Hyperuricemia (HP:0002149)	2.17397219
68	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.15117493
69	Xanthomatosis (HP:0000991)	2.14331742
70	Recurrent fungal infections (HP:0002841)	2.12469323
71	Prolonged partial thromboplastin time (HP:0003645)	2.11955380
72	Abnormality of vitamin metabolism (HP:0100508)	2.08775736
73	Mediastinal lymphadenopathy (HP:0100721)	2.06914579
74	Agammaglobulinemia (HP:0004432)	2.05822689
75	Pancreatitis (HP:0001733)	2.05161756
76	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.04645426
77	Skin rash (HP:0000988)	2.04237636
78	Keratoconjunctivitis sicca (HP:0001097)	2.03425891
79	Ileus (HP:0002595)	2.03395200
80	Pigmentary retinal degeneration (HP:0001146)	2.02562272
81	Dicarboxylic aciduria (HP:0003215)	2.02138550
82	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.02138550
83	Hyperphosphaturia (HP:0003109)	2.01137166
84	Hemiplegia (HP:0002301)	2.00868570
85	Urticaria (HP:0001025)	2.00416572
86	Growth hormone excess (HP:0000845)	2.00021632
87	Premature loss of primary teeth (HP:0006323)	1.96613943
88	Abnormal hair laboratory examination (HP:0003328)	1.96471523
89	Abnormal urine phosphate concentration (HP:0012599)	1.92876531
90	Vacuolated lymphocytes (HP:0001922)	1.92766530
91	Pulmonary infiltrates (HP:0002113)	1.92342325
92	Peritonitis (HP:0002586)	1.89610784
93	Increased cerebral lipofuscin (HP:0011813)	1.89263776
94	Steatorrhea (HP:0002570)	1.88325182
95	Polygenic inheritance (HP:0010982)	1.87443055
96	Thin bony cortex (HP:0002753)	1.86979752
97	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.86623063
98	Paresthesia (HP:0003401)	1.85380521
99	Abnormal albumin level (HP:0012116)	1.84584154
100	Hypoalbuminemia (HP:0003073)	1.84584154

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.80356113
2	ERN1	4.79432121
3	RIPK4	2.96886712
4	STK24	2.45458705
5	TYK2	2.31161083
6	PRKG2	2.26746429
7	GRK6	2.18190629
8	PRKD3	2.16279099
9	EPHB1	2.11593765
10	PTK6	2.03669189
11	MAP4K1	1.99808616
12	MAP3K11	1.79588972
13	EPHA4	1.76742229
14	IRAK4	1.75534025
15	MAP3K12	1.71644319
16	BLK	1.71154185
17	TESK2	1.68800956
18	DAPK2	1.63169826
19	KIT	1.59228478
20	TNK2	1.59186045
21	ZAP70	1.55648506
22	EPHA2	1.49854592
23	MAP2K2	1.49074533
24	FGFR4	1.48212791
25	RIPK1	1.45684411
26	TBK1	1.43264738
27	MAP3K1	1.41783781
28	EPHA3	1.32066906
29	BTK	1.24289930
30	MYLK	1.23837713
31	TAOK1	1.21677277
32	STK16	1.21644408
33	MST1R	1.19350456
34	PRKD2	1.15656818
35	GRK1	1.15439014
36	CSK	1.14889304
37	SIK3	1.12495249
38	SYK	1.12352476
39	JAK2	1.09193344
40	PDPK1	1.08279425
41	MAP2K3	0.97630099
42	KSR2	0.96482989
43	EPHB2	0.96229967
44	PRPF4B	0.93712548
45	MAP2K6	0.93290434
46	CDK19	0.93002066
47	JAK3	0.92547487
48	IRAK1	0.91884002
49	IKBKE	0.91692300
50	ITK	0.90150331
51	FES	0.88876830
52	TEC	0.87727207
53	ILK	0.87691740
54	MAP3K2	0.87182574
55	PRKCZ	0.85353406
56	OXSR1	0.84897390
57	LYN	0.83824381
58	MAP3K3	0.78489733
59	ABL2	0.74956403
60	MATK	0.74876060
61	HCK	0.74422426
62	JAK1	0.72887904
63	SMG1	0.72568327
64	MAPKAPK3	0.72151903
65	BMX	0.71281121
66	DDR2	0.68809099
67	TRIB3	0.67524204
68	TESK1	0.65371200
69	FGFR3	0.65095344
70	TXK	0.62692737
71	PDK1	0.61623994
72	PRKCQ	0.61451808
73	SIK1	0.61188499
74	ERBB2	0.58660208
75	LCK	0.57968992
76	PAK6	0.57820586
77	ADRBK2	0.56530735
78	DAPK1	0.55255907
79	FER	0.54940045
80	LRRK2	0.54454942
81	PRKCA	0.52508032
82	FGR	0.50529786
83	SRC	0.49543535
84	BMPR2	0.49038746
85	RPS6KA2	0.46683097
86	CSF1R	0.46421849
87	CDC42BPA	0.46392322
88	ADRBK1	0.44898611
89	DYRK1B	0.44726435
90	HIPK2	0.43447820
91	PRKCD	0.42912391
92	PAK4	0.42876088
93	PTK2B	0.42659046
94	RPS6KL1	0.42591927
95	RPS6KC1	0.42591927
96	PRKACG	0.42112698
97	TAOK2	0.41540359
98	TNIK	0.38885363
99	RPS6KA6	0.38345479
100	FYN	0.38333375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.13155965
2	Fat digestion and absorption_Homo sapiens_hsa04975	3.77907375
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.56335435
4	Sulfur metabolism_Homo sapiens_hsa00920	3.14056196
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.73574526
6	Asthma_Homo sapiens_hsa05310	2.53690486
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.32213391
8	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.23974993
9	Renin-angiotensin system_Homo sapiens_hsa04614	2.13079731
10	Mineral absorption_Homo sapiens_hsa04978	1.99787414
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.88137216
12	Allograft rejection_Homo sapiens_hsa05330	1.84414147
13	Protein digestion and absorption_Homo sapiens_hsa04974	1.82866967
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.78496768
15	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.71989301
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.71001040
17	Histidine metabolism_Homo sapiens_hsa00340	1.66167198
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64659473
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.57637671
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55540001
21	Leishmaniasis_Homo sapiens_hsa05140	1.49149887
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47528074
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.47525350
24	Glycerolipid metabolism_Homo sapiens_hsa00561	1.46728350
25	Glutathione metabolism_Homo sapiens_hsa00480	1.36666983
26	Other glycan degradation_Homo sapiens_hsa00511	1.30457264
27	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.26015434
28	Bile secretion_Homo sapiens_hsa04976	1.25825954
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25111411
30	Caffeine metabolism_Homo sapiens_hsa00232	1.23999050
31	Pancreatic secretion_Homo sapiens_hsa04972	1.20770424
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.18615747
33	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10373896
34	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.09800312
35	Antigen processing and presentation_Homo sapiens_hsa04612	1.07310978
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.02758912
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94025767
38	Ether lipid metabolism_Homo sapiens_hsa00565	0.89495838
39	Tuberculosis_Homo sapiens_hsa05152	0.87899671
40	Fatty acid degradation_Homo sapiens_hsa00071	0.84828339
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.83018605
42	Chemokine signaling pathway_Homo sapiens_hsa04062	0.82806643
43	Retinol metabolism_Homo sapiens_hsa00830	0.81759977
44	Pentose phosphate pathway_Homo sapiens_hsa00030	0.80722561
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79805320
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78925814
47	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.78448666
48	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.76625646
49	Sulfur relay system_Homo sapiens_hsa04122	0.76384086
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74879609
51	Galactose metabolism_Homo sapiens_hsa00052	0.74738590
52	Pertussis_Homo sapiens_hsa05133	0.73692196
53	Osteoclast differentiation_Homo sapiens_hsa04380	0.72821630
54	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72623858
55	Viral myocarditis_Homo sapiens_hsa05416	0.68457314
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66731003
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64216951
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62571043
59	Phagosome_Homo sapiens_hsa04145	0.61266167
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.60045756
61	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.58882054
62	Hepatitis C_Homo sapiens_hsa05160	0.57494809
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.55955807
64	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.53056010
65	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.52319052
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51650103
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50159851
68	Toxoplasmosis_Homo sapiens_hsa05145	0.50098535
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47585262
70	Rheumatoid arthritis_Homo sapiens_hsa05323	0.46983109
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.45789429
72	Influenza A_Homo sapiens_hsa05164	0.45754438
73	Complement and coagulation cascades_Homo sapiens_hsa04610	0.45752845
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44513266
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43420620
76	Prion diseases_Homo sapiens_hsa05020	0.42191122
77	Insulin secretion_Homo sapiens_hsa04911	0.40520797
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.40361975
79	African trypanosomiasis_Homo sapiens_hsa05143	0.37823116
80	Primary immunodeficiency_Homo sapiens_hsa05340	0.36913536
81	Tryptophan metabolism_Homo sapiens_hsa00380	0.35570826
82	Lysosome_Homo sapiens_hsa04142	0.33279988
83	GnRH signaling pathway_Homo sapiens_hsa04912	0.32176828
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.31767212
85	Renin secretion_Homo sapiens_hsa04924	0.31329952
86	Regulation of autophagy_Homo sapiens_hsa04140	0.30450228
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.29983569
88	Phenylalanine metabolism_Homo sapiens_hsa00360	0.29628900
89	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28697099
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26580136
91	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.25876621
92	Amoebiasis_Homo sapiens_hsa05146	0.25847773
93	Salmonella infection_Homo sapiens_hsa05132	0.25805358
94	Peroxisome_Homo sapiens_hsa04146	0.25384412
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.24696868
96	Salivary secretion_Homo sapiens_hsa04970	0.24519062
97	Endocytosis_Homo sapiens_hsa04144	0.23616294
98	Folate biosynthesis_Homo sapiens_hsa00790	0.23073568
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.22431674
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22253133

KRT8P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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