ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to ATP (GO:0071318)	9.41779922
2	negative regulation of cell aging (GO:0090344)	9.31428628
3	GDP-mannose metabolic process (GO:0019673)	9.18470155
4	DNA strand renaturation (GO:0000733)	9.13598931
5	meiotic chromosome segregation (GO:0045132)	9.06193493
6	rRNA methylation (GO:0031167)	8.26175793
7	rRNA modification (GO:0000154)	7.28755138
8	adenosine receptor signaling pathway (GO:0001973)	7.26166370
9	adenine nucleotide transport (GO:0051503)	6.98239130
10	regulation of skeletal muscle contraction (GO:0014819)	6.82966295
11	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	6.79059234
12	purinergic nucleotide receptor signaling pathway (GO:0035590)	6.78355611
13	purine ribonucleotide transport (GO:0015868)	6.65027432
14	nucleotide transmembrane transport (GO:1901679)	5.99433703
15	positive regulation of protein kinase C signaling (GO:0090037)	5.89043128
16	nucleoside transmembrane transport (GO:1901642)	5.84444154
17	DNA replication checkpoint (GO:0000076)	5.75685568
18	sensory perception of taste (GO:0050909)	5.70356159
19	purine nucleotide transport (GO:0015865)	5.53665878
20	behavioral response to nicotine (GO:0035095)	5.46025725
21	urinary tract smooth muscle contraction (GO:0014848)	5.45476333
22	peristalsis (GO:0030432)	5.37098410
23	lens fiber cell differentiation (GO:0070306)	5.32886441
24	regulation of protein kinase A signaling (GO:0010738)	5.14745008
25	response to ATP (GO:0033198)	4.99605624
26	regulation of synapse structural plasticity (GO:0051823)	4.91280068
27	histone phosphorylation (GO:0016572)	4.90819524
28	purinergic receptor signaling pathway (GO:0035587)	4.76461705
29	sex determination (GO:0007530)	4.59287192
30	melanin biosynthetic process (GO:0042438)	4.51318726
31	regulation of cell aging (GO:0090342)	4.46295852
32	nucleotide-sugar biosynthetic process (GO:0009226)	4.29872772
33	protein carboxylation (GO:0018214)	4.23394051
34	peptidyl-glutamic acid carboxylation (GO:0017187)	4.23394051
35	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	4.23207862
36	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	4.23207862
37	tRNA modification (GO:0006400)	4.22576440
38	melanin metabolic process (GO:0006582)	4.16370686
39	nucleoside transport (GO:0015858)	4.16322740
40	sialylation (GO:0097503)	4.10177600
41	UV protection (GO:0009650)	4.04553537
42	neuromuscular synaptic transmission (GO:0007274)	4.00576661
43	positive regulation of catecholamine secretion (GO:0033605)	3.93001320
44	gonadal mesoderm development (GO:0007506)	3.81802282
45	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.81280778
46	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.78002289
47	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.78002289
48	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.78002289
49	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.75954516
50	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.74445795
51	secondary metabolite biosynthetic process (GO:0044550)	3.65316668
52	mitochondrion distribution (GO:0048311)	3.60105424
53	detection of light stimulus involved in visual perception (GO:0050908)	3.57252397
54	detection of light stimulus involved in sensory perception (GO:0050962)	3.57252397
55	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.56844007
56	protein import into peroxisome matrix (GO:0016558)	3.55504409
57	reciprocal meiotic recombination (GO:0007131)	3.54504945
58	reciprocal DNA recombination (GO:0035825)	3.54504945
59	grooming behavior (GO:0007625)	3.52951866
60	snRNA transcription (GO:0009301)	3.43546468
61	regulation of phospholipid biosynthetic process (GO:0071071)	3.43509124
62	cilium or flagellum-dependent cell motility (GO:0001539)	3.41904608
63	activation of adenylate cyclase activity (GO:0007190)	3.34311287
64	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.31549873
65	regulation of heat generation (GO:0031650)	3.27997014
66	positive regulation of heat generation (GO:0031652)	3.26544953
67	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.23165256
68	regulation of action potential (GO:0098900)	3.20665385
69	nucleotide transport (GO:0006862)	3.20640263
70	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.19656072
71	mitotic cell cycle arrest (GO:0071850)	3.16063328
72	anatomical structure regression (GO:0060033)	3.05822857
73	glutathione metabolic process (GO:0006749)	3.04696154
74	transepithelial transport (GO:0070633)	3.04452365
75	keratinocyte development (GO:0003334)	3.03952354
76	estrogen biosynthetic process (GO:0006703)	2.96138042
77	phasic smooth muscle contraction (GO:0014821)	2.95787626
78	leukotriene biosynthetic process (GO:0019370)	2.94413012
79	RNA methylation (GO:0001510)	2.88688461
80	mismatch repair (GO:0006298)	2.88416770
81	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.87606165
82	urogenital system development (GO:0001655)	2.87245870
83	positive regulation of adenylate cyclase activity (GO:0045762)	2.86230862
84	DNA duplex unwinding (GO:0032508)	2.84550358
85	folic acid metabolic process (GO:0046655)	2.84409854
86	RNA modification (GO:0009451)	2.83595873
87	phosphatidylglycerol biosynthetic process (GO:0006655)	2.83088578
88	DNA geometric change (GO:0032392)	2.79914809
89	water-soluble vitamin biosynthetic process (GO:0042364)	2.79200889
90	interferon-gamma production (GO:0032609)	2.78728808
91	sympathetic nervous system development (GO:0048485)	2.78323810
92	sphingomyelin metabolic process (GO:0006684)	2.75426902
93	phosphate ion transmembrane transport (GO:0035435)	2.73824043
94	muscle fiber development (GO:0048747)	2.68442744
95	cellular anion homeostasis (GO:0030002)	2.66531824
96	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.64808482
97	mRNA cleavage (GO:0006379)	2.62886018
98	synaptic transmission, cholinergic (GO:0007271)	2.62328487
99	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.60989676
100	positive regulation of cAMP biosynthetic process (GO:0030819)	2.60407058

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	4.60411725
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.28263904
3	XRN2_22483619_ChIP-Seq_HELA_Human	3.22162722
4	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.05281991
5	P68_20966046_ChIP-Seq_HELA_Human	2.93912790
6	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.80603809
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.70568882
8	MAF_26560356_Chip-Seq_TH2_Human	2.65748446
9	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.54630618
10	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.44154973
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.40162647
12	LXR_22292898_ChIP-Seq_THP-1_Human	2.39668133
13	E2F1_20622854_ChIP-Seq_HELA_Human	2.27723152
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24623155
15	CTCF_27219007_Chip-Seq_Bcells_Human	2.20576682
16	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.17080085
17	BCOR_27268052_Chip-Seq_Bcells_Human	2.15394432
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.12527072
19	PHF8_20622854_ChIP-Seq_HELA_Human	2.11653149
20	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.10152725
21	MAF_26560356_Chip-Seq_TH1_Human	2.04145579
22	BCL6_27268052_Chip-Seq_Bcells_Human	2.03938430
23	VDR_24763502_ChIP-Seq_THP-1_Human	2.02815550
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.02072965
25	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.01664888
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01360489
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.01273757
28	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.01063207
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.00698458
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.92231366
31	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.90916921
32	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.89444098
33	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.85669012
34	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.82059497
35	GATA1_22025678_ChIP-Seq_K562_Human	1.78351342
36	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.78310587
37	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.75843634
38	RACK7_27058665_Chip-Seq_MCF-7_Human	1.75088725
39	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.74472438
40	SMC4_20622854_ChIP-Seq_HELA_Human	1.72385380
41	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.72128791
42	CTCF_21964334_Chip-Seq_Bcells_Human	1.70143780
43	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.65865659
44	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.60982535
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58900003
46	ERA_21632823_ChIP-Seq_H3396_Human	1.53550843
47	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.52173719
48	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.50629725
49	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.48872572
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46163363
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.43971592
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.43335643
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.43175121
54	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42935940
55	GABP_19822575_ChIP-Seq_HepG2_Human	1.42640366
56	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.42576092
57	UTX_26944678_Chip-Seq_JUKART_Human	1.39951114
58	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.39608246
59	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.39438517
60	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39105603
61	CIITA_25753668_ChIP-Seq_RAJI_Human	1.36051410
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.35385701
63	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.35179292
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.34717739
65	MYC_22102868_ChIP-Seq_BL_Human	1.34632361
66	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.34083682
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.34038390
68	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.32159565
69	TP53_22127205_ChIP-Seq_IMR90_Human	1.31967624
70	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30852287
71	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30616792
72	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.30601032
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.30451902
74	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30350787
75	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.28203702
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27195923
77	SA1_27219007_Chip-Seq_Bcells_Human	1.25472414
78	CREB1_26743006_Chip-Seq_LNCaP_Human	1.23878068
79	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.23721660
80	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.22836674
81	OCT4_20526341_ChIP-Seq_ESCs_Human	1.21898373
82	KDM2B_26808549_Chip-Seq_DND41_Human	1.19605154
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.18549150
84	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.17162317
85	TTF2_22483619_ChIP-Seq_HELA_Human	1.15955758
86	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14244320
87	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.14177676
88	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.12454718
89	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.12247949
90	EWS_26573619_Chip-Seq_HEK293_Human	1.12207872
91	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11037705
92	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.06725426
93	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.05063198
94	TCF7_22412390_ChIP-Seq_EML_Mouse	1.05001222
95	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.04906801
96	NCOR1_26117541_ChIP-Seq_K562_Human	1.04499722
97	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03318399
98	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.02961311
99	ATF3_27146783_Chip-Seq_COLON_Human	1.02650604
100	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.02224231

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	7.56018820
2	MP0003136_yellow_coat_color	7.42183110
3	MP0001986_abnormal_taste_sensitivity	6.68839005
4	MP0005174_abnormal_tail_pigmentation	6.30947891
5	MP0005423_abnormal_somatic_nervous	6.01224673
6	MP0005409_darkened_coat_color	3.69457636
7	MP0005083_abnormal_biliary_tract	3.68559168
8	MP0001188_hyperpigmentation	3.60396174
9	MP0002638_abnormal_pupillary_reflex	3.19837094
10	MP0001968_abnormal_touch/_nociception	3.11670303
11	MP0004381_abnormal_hair_follicle	2.46909936
12	MP0002736_abnormal_nociception_after	2.46431640
13	MP0000015_abnormal_ear_pigmentation	2.38575539
14	MP0001756_abnormal_urination	1.97164863
15	MP0003111_abnormal_nucleus_morphology	1.91565929
16	MP0001502_abnormal_circadian_rhythm	1.66753982
17	MP0000013_abnormal_adipose_tissue	1.62140165
18	MP0003693_abnormal_embryo_hatching	1.59616458
19	MP0000538_abnormal_urinary_bladder	1.56996664
20	MP0010094_abnormal_chromosome_stability	1.53914340
21	MP0000751_myopathy	1.47616740
22	MP0008875_abnormal_xenobiotic_pharmacok	1.35353202
23	MP0005084_abnormal_gallbladder_morpholo	1.31748527
24	MP0000750_abnormal_muscle_regeneration	1.28947772
25	MP0008057_abnormal_DNA_replication	1.28117575
26	MP0010386_abnormal_urinary_bladder	1.24816954
27	MP0005220_abnormal_exocrine_pancreas	1.23895617
28	MP0004130_abnormal_muscle_cell	1.22473969
29	MP0002735_abnormal_chemical_nociception	1.20119266
30	MP0004043_abnormal_pH_regulation	1.18047304
31	MP0004957_abnormal_blastocyst_morpholog	1.14498848
32	MP0001661_extended_life_span	1.13521713
33	MP0000003_abnormal_adipose_tissue	1.07469821
34	MP0005551_abnormal_eye_electrophysiolog	1.06859732
35	MP0003705_abnormal_hypodermis_morpholog	1.04697401
36	MP0005332_abnormal_amino_acid	1.04229472
37	MP0003077_abnormal_cell_cycle	1.01885437
38	MP0005584_abnormal_enzyme/coenzyme_acti	1.01789203
39	MP0003453_abnormal_keratinocyte_physiol	1.00171275
40	MP0004019_abnormal_vitamin_homeostasis	0.87647585
41	MP0005076_abnormal_cell_differentiation	0.85383466
42	MP0001664_abnormal_digestion	0.84928370
43	MP0002160_abnormal_reproductive_system	0.80050313
44	MP0002075_abnormal_coat/hair_pigmentati	0.79376974
45	MP0001346_abnormal_lacrimal_gland	0.77053289
46	MP0001970_abnormal_pain_threshold	0.70205794
47	MP0004197_abnormal_fetal_growth/weight/	0.69841514
48	MP0005330_cardiomyopathy	0.69317755
49	MP0002019_abnormal_tumor_incidence	0.66129314
50	MP0002095_abnormal_skin_pigmentation	0.65555110
51	MP0001765_abnormal_ion_homeostasis	0.64808965
52	MP0000367_abnormal_coat/_hair	0.62882898
53	MP0000358_abnormal_cell_content/	0.61891814
54	MP0005365_abnormal_bile_salt	0.60993412
55	MP0000470_abnormal_stomach_morphology	0.55264764
56	MP0003632_abnormal_nervous_system	0.54973769
57	MP0002928_abnormal_bile_duct	0.54738103
58	MP0003878_abnormal_ear_physiology	0.54656317
59	MP0005377_hearing/vestibular/ear_phenot	0.54656317
60	MP0001186_pigmentation_phenotype	0.52251125
61	MP0001958_emphysema	0.52036145
62	MP0001905_abnormal_dopamine_level	0.50489170
63	MP0005501_abnormal_skin_physiology	0.47855764
64	MP0000427_abnormal_hair_cycle	0.46817364
65	MP0002909_abnormal_adrenal_gland	0.46755715
66	MP0002210_abnormal_sex_determination	0.46722966
67	MP0010771_integument_phenotype	0.45518967
68	MP0000371_diluted_coat_color	0.45210437
69	MP0005410_abnormal_fertilization	0.45174753
70	MP0009278_abnormal_bone_marrow	0.44648989
71	MP0000747_muscle_weakness	0.44479606
72	MP0004142_abnormal_muscle_tone	0.41875615
73	MP0004215_abnormal_myocardial_fiber	0.40656258
74	MP0002254_reproductive_system_inflammat	0.40475351
75	MP0003448_altered_tumor_morphology	0.40306802
76	MP0008770_decreased_survivor_rate	0.39776703
77	MP0009931_abnormal_skin_appearance	0.39719805
78	MP0001324_abnormal_eye_pigmentation	0.39682891
79	MP0004484_altered_response_of	0.39422171
80	MP0005253_abnormal_eye_physiology	0.36952760
81	MP0003091_abnormal_cell_migration	0.35552296
82	MP0002697_abnormal_eye_size	0.35264500
83	MP0003786_premature_aging	0.34561425
84	MP0009643_abnormal_urine_homeostasis	0.34101734
85	MP0003137_abnormal_impulse_conducting	0.34000648
86	MP0001873_stomach_inflammation	0.33815515
87	MP0002177_abnormal_outer_ear	0.33810894
88	MP0005085_abnormal_gallbladder_physiolo	0.33240044
89	MP0000778_abnormal_nervous_system	0.33236846
90	MP0003984_embryonic_growth_retardation	0.32854788
91	MP0003195_calcinosis	0.32456186
92	MP0008058_abnormal_DNA_repair	0.32087560
93	MP0003221_abnormal_cardiomyocyte_apopto	0.31879878
94	MP0002088_abnormal_embryonic_growth/wei	0.31252085
95	MP0002136_abnormal_kidney_physiology	0.31117844
96	MP0001191_abnormal_skin_condition	0.30889936
97	MP0001929_abnormal_gametogenesis	0.29725560
98	MP0006276_abnormal_autonomic_nervous	0.29652561
99	MP0002086_abnormal_extraembryonic_tissu	0.29511286
100	MP0004147_increased_porphyrin_level	0.28878473

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rib fusion (HP:0000902)	6.62694464
2	Rectovaginal fistula (HP:0000143)	5.93398023
3	Rectal fistula (HP:0100590)	5.93398023
4	Intestinal fistula (HP:0100819)	5.66793982
5	Testicular atrophy (HP:0000029)	5.43187349
6	Poikiloderma (HP:0001029)	5.34371877
7	Vaginal fistula (HP:0004320)	5.31929323
8	Attenuation of retinal blood vessels (HP:0007843)	5.10878943
9	Facial hemangioma (HP:0000329)	5.06246780
10	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.80665501
11	Congenital stationary night blindness (HP:0007642)	4.73896479
12	Annular pancreas (HP:0001734)	4.54248954
13	Thin bony cortex (HP:0002753)	4.53532896
14	Popliteal pterygium (HP:0009756)	4.28541958
15	Coronal craniosynostosis (HP:0004440)	4.26647082
16	Ulnar bowing (HP:0003031)	4.19673327
17	Facial diplegia (HP:0001349)	4.14168634
18	Chorioretinal atrophy (HP:0000533)	4.04247954
19	Short chin (HP:0000331)	4.04222207
20	Turricephaly (HP:0000262)	3.98826649
21	Bony spicule pigmentary retinopathy (HP:0007737)	3.97252062
22	Dyschromatopsia (HP:0007641)	3.95214926
23	Aplasia of the musculature (HP:0100854)	3.93287299
24	Akinesia (HP:0002304)	3.84656069
25	Squamous cell carcinoma (HP:0002860)	3.75970580
26	Abnormality of the intrinsic pathway (HP:0010989)	3.73224563
27	Anteriorly placed anus (HP:0001545)	3.68919275
28	Patellar aplasia (HP:0006443)	3.50712527
29	Capillary hemangiomas (HP:0005306)	3.45619520
30	Fetal akinesia sequence (HP:0001989)	3.43589028
31	Birth length less than 3rd percentile (HP:0003561)	3.43401577
32	Hypoplasia of the pons (HP:0012110)	3.38368734
33	Absent thumb (HP:0009777)	3.37287686
34	Aplasia/Hypoplasia of the patella (HP:0006498)	3.21395115
35	Delayed epiphyseal ossification (HP:0002663)	3.15933810
36	Abnormality of the pons (HP:0007361)	3.10166494
37	Absent radius (HP:0003974)	3.07228706
38	Amniotic constriction ring (HP:0009775)	3.06617684
39	Abnormality of placental membranes (HP:0011409)	3.06617684
40	Prolonged partial thromboplastin time (HP:0003645)	3.02166646
41	Abnormal albumin level (HP:0012116)	3.01404650
42	Hypoalbuminemia (HP:0003073)	3.01404650
43	Absent forearm bone (HP:0003953)	2.91519917
44	Aplasia involving forearm bones (HP:0009822)	2.91519917
45	Increased number of teeth (HP:0011069)	2.80051443
46	Enlarged epiphyses (HP:0010580)	2.78159869
47	Premature graying of hair (HP:0002216)	2.73450081
48	Male infertility (HP:0003251)	2.69656887
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.69521396
50	Reduced antithrombin III activity (HP:0001976)	2.69174107
51	Abnormality of the costochondral junction (HP:0000919)	2.65961416
52	Flat occiput (HP:0005469)	2.61554682
53	Basal cell carcinoma (HP:0002671)	2.60866225
54	Widely patent fontanelles and sutures (HP:0004492)	2.58181050
55	Joint hemorrhage (HP:0005261)	2.57646640
56	Choanal stenosis (HP:0000452)	2.56846579
57	Short thumb (HP:0009778)	2.55857303
58	Hypophosphatemic rickets (HP:0004912)	2.55286001
59	Short humerus (HP:0005792)	2.53749229
60	Myotonia (HP:0002486)	2.48310580
61	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.45466128
62	Thin ribs (HP:0000883)	2.45172488
63	Pendular nystagmus (HP:0012043)	2.37408057
64	Breast hypoplasia (HP:0003187)	2.35203138
65	Abnormality of homocysteine metabolism (HP:0010919)	2.28850446
66	Homocystinuria (HP:0002156)	2.28850446
67	Aplasia/hypoplasia of the humerus (HP:0006507)	2.25898082
68	Abnormal drinking behavior (HP:0030082)	2.21573657
69	Polydipsia (HP:0001959)	2.21573657
70	Decreased circulating renin level (HP:0003351)	2.16488502
71	Hemorrhage of the eye (HP:0011885)	2.15947932
72	Narrow nasal bridge (HP:0000446)	2.15702122
73	Malignant hyperthermia (HP:0002047)	2.14281070
74	Choroideremia (HP:0001139)	2.11906001
75	Neonatal respiratory distress (HP:0002643)	2.09032561
76	Microvesicular hepatic steatosis (HP:0001414)	2.08752042
77	Zonular cataract (HP:0010920)	2.07165336
78	Small hand (HP:0200055)	2.05971561
79	Hyperinsulinemic hypoglycemia (HP:0000825)	2.05496101
80	Atrioventricular block (HP:0001678)	2.04377461
81	Abnormality of the hepatic vasculature (HP:0006707)	2.03149712
82	Bowed forearm bones (HP:0003956)	2.02373812
83	Bowing of the arm (HP:0006488)	2.02373812
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.01093162
85	Joint stiffness (HP:0001387)	2.00201507
86	Cystic hygroma (HP:0000476)	2.00108193
87	Tubular atrophy (HP:0000092)	1.96155469
88	Pterygium (HP:0001059)	1.92596005
89	Duplicated collecting system (HP:0000081)	1.91573800
90	Myopathic facies (HP:0002058)	1.91016532
91	Abnormal epiphyseal ossification (HP:0010656)	1.90997577
92	Type I transferrin isoform profile (HP:0003642)	1.88667220
93	Type 2 muscle fiber atrophy (HP:0003554)	1.86764725
94	Hypoplasia of the radius (HP:0002984)	1.84581305
95	Decreased central vision (HP:0007663)	1.81566968
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80750632
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.80343227
98	Abnormality of the neuromuscular junction (HP:0003398)	1.77624562
99	Fatigable weakness (HP:0003473)	1.77624562
100	Hypoplasia of the ulna (HP:0003022)	1.77334087

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	7.61170750
2	WNK4	4.94203903
3	TLK1	3.74033446
4	BLK	3.70922687
5	ZAK	3.21042554
6	ACVR1B	3.01476128
7	STK16	2.90786475
8	MUSK	2.65995566
9	TESK2	2.56034845
10	GRK6	2.48980525
11	BRD4	2.48207638
12	SIK2	1.92987242
13	CDK12	1.92268846
14	BMPR1B	1.88918523
15	PDK2	1.88312898
16	FRK	1.86661598
17	PKN2	1.74486253
18	CCNB1	1.62937351
19	MAP2K3	1.45686161
20	ADRBK1	1.45237295
21	MAPK11	1.27687456
22	NEK2	1.25303329
23	IRAK2	1.24818550
24	PIM2	1.20285383
25	MELK	1.17499555
26	STK39	1.12406953
27	WNK1	1.11622774
28	ATR	1.10160495
29	BRSK2	1.09910878
30	ADRBK2	1.06020326
31	CDK4	1.02469792
32	RAF1	1.00088009
33	RPS6KA5	0.97506775
34	MAP2K6	0.97095014
35	TRIM28	0.95236333
36	CHEK2	0.90804821
37	DYRK3	0.87494644
38	ZAP70	0.85085403
39	MST1R	0.83721953
40	CDK6	0.80557428
41	PDPK1	0.79776663
42	TGFBR1	0.77704808
43	SIK1	0.76508161
44	PBK	0.74287797
45	OXSR1	0.73350703
46	STK11	0.71810312
47	PINK1	0.66225257
48	CDK15	0.65807003
49	MET	0.65668792
50	PLK1	0.65145383
51	CDK18	0.62691507
52	CSNK1D	0.62247553
53	TRIB3	0.60909629
54	RPS6KA6	0.60144932
55	FLT3	0.58114016
56	CDK11A	0.58097892
57	MAPK12	0.54102658
58	ICK	0.52041788
59	DYRK1B	0.51848303
60	DYRK2	0.51254432
61	MAP2K4	0.50504770
62	PIM1	0.49846726
63	CAMKK2	0.49625953
64	MKNK2	0.48502016
65	SGK494	0.48326784
66	SGK223	0.48326784
67	PRKAA1	0.47090246
68	MAPK8	0.44800022
69	AURKA	0.44231872
70	DAPK2	0.44157997
71	IKBKE	0.43765239
72	RPS6KA2	0.43450397
73	CSNK1A1L	0.42872895
74	CDK8	0.42641109
75	GRK1	0.42550675
76	PRKD1	0.39890796
77	RPS6KC1	0.38429721
78	RPS6KL1	0.38429721
79	RPS6KB1	0.35616723
80	MTOR	0.35261488
81	KSR2	0.32417861
82	NUAK1	0.32199171
83	NEK9	0.31330666
84	STK4	0.29218631
85	CDK14	0.28743588
86	MAP3K7	0.28306886
87	BMX	0.27013023
88	AKT2	0.24859995
89	CDK2	0.24723492
90	NEK6	0.24245404
91	AKT3	0.24170380
92	ERN1	0.23978274
93	CDK1	0.23737354
94	MAP3K2	0.23124101
95	SRPK1	0.23003620
96	EPHA2	0.21801016
97	VRK1	0.20273149
98	RPS6KA1	0.18446468
99	CHUK	0.17617710
100	ATM	0.16741385

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	7.86501209
2	Sulfur relay system_Homo sapiens_hsa04122	6.18861588
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.23783836
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.22722736
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.27325658
6	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.91398743
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61960488
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.54595179
9	Taste transduction_Homo sapiens_hsa04742	2.00783151
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.92308285
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91306573
12	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.75894468
13	Circadian rhythm_Homo sapiens_hsa04710	1.71052855
14	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.68126056
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58457150
16	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.56939389
17	Nicotine addiction_Homo sapiens_hsa05033	1.50118172
18	RNA polymerase_Homo sapiens_hsa03020	1.44159243
19	Homologous recombination_Homo sapiens_hsa03440	1.42050654
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33133119
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.31067146
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.20913761
23	Lysine degradation_Homo sapiens_hsa00310	1.17636996
24	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.13725962
25	Sphingolipid metabolism_Homo sapiens_hsa00600	1.11673994
26	Alcoholism_Homo sapiens_hsa05034	1.06628229
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97083327
28	Basal cell carcinoma_Homo sapiens_hsa05217	0.96573035
29	Hippo signaling pathway_Homo sapiens_hsa04390	0.89973171
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86948050
31	Selenocompound metabolism_Homo sapiens_hsa00450	0.81967357
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.80609765
33	Melanogenesis_Homo sapiens_hsa04916	0.78132899
34	Cell cycle_Homo sapiens_hsa04110	0.76323128
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76152115
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74892137
37	Nitrogen metabolism_Homo sapiens_hsa00910	0.73837320
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.70671234
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70643625
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68796790
41	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.67561316
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66928592
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.65824032
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65008180
45	Base excision repair_Homo sapiens_hsa03410	0.64093402
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63386407
47	Arginine biosynthesis_Homo sapiens_hsa00220	0.62491995
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.60440357
49	Basal transcription factors_Homo sapiens_hsa03022	0.58322793
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58321352
51	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58097457
52	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57118667
53	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.53798612
54	One carbon pool by folate_Homo sapiens_hsa00670	0.51427982
55	Bladder cancer_Homo sapiens_hsa05219	0.50410042
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.48359038
57	Cocaine addiction_Homo sapiens_hsa05030	0.47443957
58	Purine metabolism_Homo sapiens_hsa00230	0.46283371
59	ABC transporters_Homo sapiens_hsa02010	0.36267109
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35613885
61	Morphine addiction_Homo sapiens_hsa05032	0.31613367
62	RNA transport_Homo sapiens_hsa03013	0.30743467
63	mTOR signaling pathway_Homo sapiens_hsa04150	0.30451344
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.30360477
65	Metabolic pathways_Homo sapiens_hsa01100	0.29674525
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.28477858
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26386525
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25688269
69	FoxO signaling pathway_Homo sapiens_hsa04068	0.25681643
70	Other glycan degradation_Homo sapiens_hsa00511	0.25491519
71	Phototransduction_Homo sapiens_hsa04744	0.25083585
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.25000839
73	DNA replication_Homo sapiens_hsa03030	0.23527481
74	Fatty acid degradation_Homo sapiens_hsa00071	0.22020932
75	Lysosome_Homo sapiens_hsa04142	0.21723202
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20705036
77	Amphetamine addiction_Homo sapiens_hsa05031	0.20690014
78	Cholinergic synapse_Homo sapiens_hsa04725	0.19947085
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.16801670
80	Gap junction_Homo sapiens_hsa04540	0.16364519
81	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.16178729
82	Phenylalanine metabolism_Homo sapiens_hsa00360	0.15630810
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.15561673
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.15073754
85	Insulin resistance_Homo sapiens_hsa04931	0.15023761
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.14727484
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.14154244
88	RNA degradation_Homo sapiens_hsa03018	0.12851815
89	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.12442583
90	MAPK signaling pathway_Homo sapiens_hsa04010	0.11603609
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.11033661
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.10585424
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.08731246
94	Histidine metabolism_Homo sapiens_hsa00340	0.07783792
95	Mismatch repair_Homo sapiens_hsa03430	0.05084020
96	p53 signaling pathway_Homo sapiens_hsa04115	0.04592494
97	Glucagon signaling pathway_Homo sapiens_hsa04922	0.02846986
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.02653118
99	MicroRNAs in cancer_Homo sapiens_hsa05206	0.00788947
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	-0.0011077

KRT8P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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