ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	amino sugar catabolic process (GO:0046348)	8.57018800
2	proteasome assembly (GO:0043248)	6.15156866
3	glucosamine-containing compound metabolic process (GO:1901071)	5.46206036
4	opsonization (GO:0008228)	5.23172074
5	positive regulation of interleukin-1 beta secretion (GO:0050718)	4.75710733
6	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.71957806
7	cellular response to zinc ion (GO:0071294)	4.57873464
8	polysaccharide catabolic process (GO:0000272)	4.48082544
9	positive regulation of interleukin-1 secretion (GO:0050716)	4.47117325
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.45771112
11	ATP synthesis coupled proton transport (GO:0015986)	4.45771112
12	male meiosis I (GO:0007141)	4.45383596
13	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	4.40321691
14	peptidyl-histidine modification (GO:0018202)	4.39464408
15	regulation of interleukin-1 beta secretion (GO:0050706)	4.32130548
16	rhodopsin mediated signaling pathway (GO:0016056)	4.25943647
17	negative regulation of amino acid transport (GO:0051956)	3.97026008
18	nephron epithelium morphogenesis (GO:0072088)	3.92674699
19	nephron tubule morphogenesis (GO:0072078)	3.92674699
20	cornea development in camera-type eye (GO:0061303)	3.90250161
21	amino sugar metabolic process (GO:0006040)	3.86245228
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.84661388
23	rRNA modification (GO:0000154)	3.79844602
24	regulation of interleukin-1 secretion (GO:0050704)	3.78987802
25	lateral sprouting from an epithelium (GO:0060601)	3.69731806
26	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.64428244
27	positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	3.61771768
28	cilium or flagellum-dependent cell motility (GO:0001539)	3.49008092
29	meiosis I (GO:0007127)	3.48545640
30	transmission of nerve impulse (GO:0019226)	3.47061626
31	establishment of tissue polarity (GO:0007164)	3.45581779
32	establishment of planar polarity (GO:0001736)	3.45581779
33	positive regulation of interleukin-1 production (GO:0032732)	3.44919291
34	positive regulation of ERBB signaling pathway (GO:1901186)	3.44359991
35	activation of MAPKKK activity (GO:0000185)	3.43942076
36	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.42126486
37	regulation of histone H3-K9 methylation (GO:0051570)	3.40966545
38	protein localization to cilium (GO:0061512)	3.40762348
39	membrane tubulation (GO:0097320)	3.38741107
40	cellular ketone body metabolic process (GO:0046950)	3.35891165
41	sequestering of actin monomers (GO:0042989)	3.29999343
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24347945
43	ribosomal small subunit assembly (GO:0000028)	3.22613004
44	water-soluble vitamin biosynthetic process (GO:0042364)	3.19272482
45	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.16559813
46	sex differentiation (GO:0007548)	3.16199600
47	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.15514459
48	electron transport chain (GO:0022900)	3.12921572
49	positive regulation of cytokine secretion (GO:0050715)	3.12087312
50	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.11967292
51	chaperone-mediated protein transport (GO:0072321)	3.11526361
52	positive regulation of interleukin-1 beta production (GO:0032731)	3.10474632
53	response to fungus (GO:0009620)	3.07340532
54	respiratory electron transport chain (GO:0022904)	3.05762375
55	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	3.02225541
56	rRNA methylation (GO:0031167)	3.00780472
57	ribonucleoprotein complex disassembly (GO:0032988)	3.00427356
58	glycerophospholipid catabolic process (GO:0046475)	2.99245878
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97960347
60	digestion (GO:0007586)	2.97539355
61	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.97401941
62	ketone body metabolic process (GO:1902224)	2.97163718
63	phosphate ion homeostasis (GO:0055062)	2.96911778
64	trivalent inorganic anion homeostasis (GO:0072506)	2.96911778
65	kinetochore assembly (GO:0051382)	2.91724624
66	cerebellar Purkinje cell layer development (GO:0021680)	2.89515502
67	regulation of glutamate secretion (GO:0014048)	2.86883101
68	artery smooth muscle contraction (GO:0014824)	2.84219066
69	microtubule severing (GO:0051013)	2.80804314
70	viral transcription (GO:0019083)	2.79812521
71	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.75812980
72	platelet dense granule organization (GO:0060155)	2.73151156
73	cellular anion homeostasis (GO:0030002)	2.73080169
74	collecting duct development (GO:0072044)	2.62703565
75	ATP biosynthetic process (GO:0006754)	2.62154138
76	retinal ganglion cell axon guidance (GO:0031290)	2.61474395
77	nephron tubule formation (GO:0072079)	2.61058796
78	regulation of autophagic vacuole assembly (GO:2000785)	2.60929726
79	positive regulation of chemokine production (GO:0032722)	2.60870922
80	translational termination (GO:0006415)	2.59644940
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59294034
82	termination of RNA polymerase III transcription (GO:0006386)	2.59294034
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.56296622
84	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.54658030
85	bicarbonate transport (GO:0015701)	2.54552614
86	axoneme assembly (GO:0035082)	2.49049027
87	oxidative phosphorylation (GO:0006119)	2.45787384
88	renal tubule morphogenesis (GO:0061333)	2.44088047
89	presynaptic membrane assembly (GO:0097105)	2.44043211
90	protein targeting to ER (GO:0045047)	2.43813490
91	vascular smooth muscle contraction (GO:0014829)	2.43095182
92	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.41950415
93	xenobiotic catabolic process (GO:0042178)	2.39315802
94	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.38851340
95	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.38509910
96	cell wall macromolecule metabolic process (GO:0044036)	17.9391658
97	glucosamine-containing compound catabolic process (GO:1901072)	14.2046795
98	production of molecular mediator involved in inflammatory response (GO:0002532)	12.4731216
99	positive regulation of chemokine secretion (GO:0090197)	12.2700883
100	regulation of chemokine secretion (GO:0090196)	11.2437337

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	8.72041268
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.99658083
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.59795400
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.33199524
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.21950694
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.72838589
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.67860985
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.50205416
9	VDR_22108803_ChIP-Seq_LS180_Human	2.45009768
10	BCAT_22108803_ChIP-Seq_LS180_Human	2.44528405
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40826972
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.35267369
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.30609915
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.28332358
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05082293
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99141408
17	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.93966236
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88649519
19	NCOR_22424771_ChIP-Seq_293T_Human	1.78531451
20	P300_19829295_ChIP-Seq_ESCs_Human	1.76031021
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67534429
22	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.60931630
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.54827762
24	ERG_20517297_ChIP-Seq_VCAP_Human	1.51909493
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.51074474
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.50224807
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48898246
28	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.46684615
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.45614868
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.44399774
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42775460
32	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.42196036
33	TCF4_22108803_ChIP-Seq_LS180_Human	1.39991772
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39469003
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.38263347
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38023672
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.37970694
38	HTT_18923047_ChIP-ChIP_STHdh_Human	1.30713731
39	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.30611357
40	EWS_26573619_Chip-Seq_HEK293_Human	1.29561251
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29052092
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28442625
43	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.26471902
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25077389
45	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24224963
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.22441198
47	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.20710255
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20601519
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18813849
50	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17676098
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16204604
52	RBPJ_21746931_ChIP-Seq_IB4_Human	1.13682530
53	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.11163570
54	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.09346381
55	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08968084
56	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08839283
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.08297444
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07984428
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05577780
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05030890
61	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03593967
62	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.02726892
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.02633583
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.02429045
65	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99742855
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99280889
67	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99183167
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97711619
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95733943
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95733943
71	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95640195
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94506385
73	PHF8_20622853_ChIP-Seq_HELA_Human	0.93732432
74	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93655208
75	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93047785
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.92366711
77	NFYB_21822215_ChIP-Seq_K562_Human	0.92321004
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90694349
79	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.90289470
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90090606
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.90045005
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90045005
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89835692
84	NFYA_21822215_ChIP-Seq_K562_Human	0.89290073
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88999843
86	GBX2_23144817_ChIP-Seq_PC3_Human	0.88616827
87	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.88111151
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87943469
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.87300093
90	AR_20517297_ChIP-Seq_VCAP_Human	0.87087102
91	ERA_21632823_ChIP-Seq_H3396_Human	0.86875018
92	IGF1R_20145208_ChIP-Seq_DFB_Human	0.86138191
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.85718517
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.85427103
95	ELK1_19687146_ChIP-ChIP_HELA_Human	0.85012265
96	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83527260
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.83491113
98	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.82660137
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.82470935
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.82470935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010030_abnormal_orbit_morphology	4.61456304
2	MP0001346_abnormal_lacrimal_gland	3.35289086
3	MP0005646_abnormal_pituitary_gland	3.04065404
4	MP0005551_abnormal_eye_electrophysiolog	2.76095317
5	MP0006292_abnormal_olfactory_placode	2.60104620
6	MP0005248_abnormal_Harderian_gland	2.51614873
7	MP0008872_abnormal_physiological_respon	2.49349671
8	MP0001764_abnormal_homeostasis	2.38651171
9	MP0000566_synostosis	2.37402897
10	MP0005377_hearing/vestibular/ear_phenot	2.34390843
11	MP0003878_abnormal_ear_physiology	2.34390843
12	MP0006276_abnormal_autonomic_nervous	2.31021445
13	MP0002822_catalepsy	2.20336235
14	MP0008260_abnormal_autophagy	1.99768457
15	MP0005171_absent_coat_pigmentation	1.96414970
16	MP0001293_anophthalmia	1.96387521
17	MP0000579_abnormal_nail_morphology	1.95473131
18	MP0001485_abnormal_pinna_reflex	1.91305076
19	MP0002735_abnormal_chemical_nociception	1.86975395
20	MP0000538_abnormal_urinary_bladder	1.86815215
21	MP0001542_abnormal_bone_strength	1.83570531
22	MP0005360_urolithiasis	1.80524657
23	MP0002837_dystrophic_cardiac_calcinosis	1.79852152
24	MP0002653_abnormal_ependyma_morphology	1.77225854
25	MP0004147_increased_porphyrin_level	1.73806435
26	MP0002277_abnormal_respiratory_mucosa	1.70162343
27	MP0005253_abnormal_eye_physiology	1.64937603
28	MP0003880_abnormal_central_pattern	1.63677334
29	MP0002938_white_spotting	1.63368311
30	MP0001663_abnormal_digestive_system	1.62536815
31	MP0008875_abnormal_xenobiotic_pharmacok	1.61580247
32	MP0001324_abnormal_eye_pigmentation	1.58426290
33	MP0001905_abnormal_dopamine_level	1.57557088
34	MP0000537_abnormal_urethra_morphology	1.56014172
35	MP0009379_abnormal_foot_pigmentation	1.49852445
36	MP0003936_abnormal_reproductive_system	1.47826421
37	MP0004133_heterotaxia	1.45859687
38	MP0002138_abnormal_hepatobiliary_system	1.44330285
39	MP0005257_abnormal_intraocular_pressure	1.43355453
40	MP0000516_abnormal_urinary_system	1.42507680
41	MP0005367_renal/urinary_system_phenotyp	1.42507680
42	MP0002736_abnormal_nociception_after	1.40082703
43	MP0005391_vision/eye_phenotype	1.35194936
44	MP0000751_myopathy	1.35070307
45	MP0010386_abnormal_urinary_bladder	1.31040892
46	MP0005645_abnormal_hypothalamus_physiol	1.30840317
47	MP0001919_abnormal_reproductive_system	1.30479266
48	MP0001968_abnormal_touch/_nociception	1.28544870
49	MP0002095_abnormal_skin_pigmentation	1.27994188
50	MP0002160_abnormal_reproductive_system	1.27323201
51	MP0002638_abnormal_pupillary_reflex	1.25197753
52	MP0000631_abnormal_neuroendocrine_gland	1.24936106
53	MP0000372_irregular_coat_pigmentation	1.24910534
54	MP0001529_abnormal_vocalization	1.24236768
55	MP0005381_digestive/alimentary_phenotyp	1.22902735
56	MP0009745_abnormal_behavioral_response	1.18998640
57	MP0005389_reproductive_system_phenotype	1.17130011
58	MP0005075_abnormal_melanosome_morpholog	1.11293460
59	MP0000026_abnormal_inner_ear	1.11116021
60	MP0002064_seizures	1.10770646
61	MP0000358_abnormal_cell_content/	1.09459687
62	MP0003890_abnormal_embryonic-extraembry	1.07852146
63	MP0005195_abnormal_posterior_eye	1.06589395
64	MP0001486_abnormal_startle_reflex	1.04982028
65	MP0005408_hypopigmentation	1.03984334
66	MP0001661_extended_life_span	1.03227872
67	MP0008789_abnormal_olfactory_epithelium	1.02633862
68	MP0005448_abnormal_energy_balance	1.00757142
69	MP0004215_abnormal_myocardial_fiber	1.00703984
70	MP0005636_abnormal_mineral_homeostasis	0.99429003
71	MP0001765_abnormal_ion_homeostasis	0.94543643
72	MP0002928_abnormal_bile_duct	0.94388404
73	MP0005499_abnormal_olfactory_system	0.92087890
74	MP0005394_taste/olfaction_phenotype	0.92087890
75	MP0002752_abnormal_somatic_nervous	0.88028515
76	MP0002233_abnormal_nose_morphology	0.87914932
77	MP0001835_abnormal_antigen_presentation	0.86950746
78	MP0003938_abnormal_ear_development	0.86173692
79	MP0002163_abnormal_gland_morphology	0.85968538
80	MP0001666_abnormal_nutrient_absorption	0.84101116
81	MP0002092_abnormal_eye_morphology	0.83527231
82	MP0005330_cardiomyopathy	0.81028652
83	MP0001970_abnormal_pain_threshold	0.80273827
84	MP0005670_abnormal_white_adipose	0.79410385
85	MP0004859_abnormal_synaptic_plasticity	0.76533581
86	MP0005085_abnormal_gallbladder_physiolo	0.74553638
87	MP0005197_abnormal_uvea_morphology	0.74536759
88	MP0004019_abnormal_vitamin_homeostasis	0.72855020
89	MP0005167_abnormal_blood-brain_barrier	0.72757593
90	MP0006036_abnormal_mitochondrial_physio	0.71847124
91	MP0003136_yellow_coat_color	0.71403209
92	MP0003635_abnormal_synaptic_transmissio	0.70149551
93	MP0003567_abnormal_fetal_cardiomyocyte	0.69589952
94	MP0000470_abnormal_stomach_morphology	0.69452487
95	MP0002697_abnormal_eye_size	0.68587258
96	MP0003119_abnormal_digestive_system	0.67772865
97	MP0002693_abnormal_pancreas_physiology	0.66781888
98	MP0002882_abnormal_neuron_morphology	0.66086193
99	MP0003959_abnormal_lean_body	0.65170139
100	MP0005671_abnormal_response_to	0.63844174

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	6.93515027
2	Lipid accumulation in hepatocytes (HP:0006561)	4.20769010
3	Increased hepatocellular lipid droplets (HP:0006565)	4.14011680
4	Hyperglycinemia (HP:0002154)	3.50947251
5	Optic disc pallor (HP:0000543)	3.44534445
6	Renal Fanconi syndrome (HP:0001994)	3.35474572
7	Acute encephalopathy (HP:0006846)	3.23152559
8	Chronic otitis media (HP:0000389)	3.23136502
9	Generalized aminoaciduria (HP:0002909)	3.21728390
10	Myelomeningocele (HP:0002475)	3.21697680
11	Decreased central vision (HP:0007663)	3.14933997
12	Genetic anticipation (HP:0003743)	3.13944009
13	Mitochondrial inheritance (HP:0001427)	2.97958375
14	Esophageal atresia (HP:0002032)	2.95686743
15	Abnormality of urine glucose concentration (HP:0011016)	2.92518114
16	Glycosuria (HP:0003076)	2.92518114
17	Pancreatic cysts (HP:0001737)	2.91588268
18	Acute necrotizing encephalopathy (HP:0006965)	2.90549991
19	Split foot (HP:0001839)	2.89487418
20	Pili torti (HP:0003777)	2.79407139
21	Septo-optic dysplasia (HP:0100842)	2.77100537
22	Abnormality of the hip-girdle musculature (HP:0001445)	2.69030304
23	Abnormality of the musculature of the pelvis (HP:0001469)	2.69030304
24	Increased CSF lactate (HP:0002490)	2.68385304
25	Microvesicular hepatic steatosis (HP:0001414)	2.67864568
26	Dry hair (HP:0011359)	2.67708098
27	Maternal diabetes (HP:0009800)	2.63878551
28	Limb-girdle muscle atrophy (HP:0003797)	2.63072400
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.62477799
30	Alacrima (HP:0000522)	2.56661869
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.52986432
32	Congenital sensorineural hearing impairment (HP:0008527)	2.44346812
33	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.43476795
34	Partial duplication of thumb phalanx (HP:0009944)	2.42808542
35	Urethral obstruction (HP:0000796)	2.42225419
36	Cerebral edema (HP:0002181)	2.40913869
37	Progressive macrocephaly (HP:0004481)	2.39394974
38	Progressive cerebellar ataxia (HP:0002073)	2.39130123
39	Abnormality of proline metabolism (HP:0010907)	2.36596649
40	Hydroxyprolinuria (HP:0003080)	2.36596649
41	Stenosis of the external auditory canal (HP:0000402)	2.35987443
42	Hypoglycemic coma (HP:0001325)	2.35961971
43	Cutaneous finger syndactyly (HP:0010554)	2.35155366
44	Chronic sinusitis (HP:0011109)	2.34844677
45	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.33853533
46	Short 4th metacarpal (HP:0010044)	2.33853533
47	Tetany (HP:0001281)	2.33843511
48	Hypothermia (HP:0002045)	2.29923060
49	Respiratory difficulties (HP:0002880)	2.28721762
50	Abnormality of renal resorption (HP:0011038)	2.28464782
51	Abnormality of serum amino acid levels (HP:0003112)	2.27930781
52	Hepatic necrosis (HP:0002605)	2.24759161
53	Increased intramyocellular lipid droplets (HP:0012240)	2.21448689
54	True hermaphroditism (HP:0010459)	2.18901763
55	Abnormality of DNA repair (HP:0003254)	2.15567953
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.12497232
57	Partial duplication of the phalanx of hand (HP:0009999)	2.10695987
58	Gastrointestinal atresia (HP:0002589)	2.08072674
59	Poor coordination (HP:0002370)	2.07166394
60	Abnormal pancreas size (HP:0012094)	2.06706157
61	Vaginal atresia (HP:0000148)	2.06133457
62	Increased muscle lipid content (HP:0009058)	2.04014381
63	Abnormality of the parietal bone (HP:0002696)	2.03603456
64	Abnormal hair laboratory examination (HP:0003328)	2.02756451
65	Hepatocellular necrosis (HP:0001404)	2.02620583
66	Exertional dyspnea (HP:0002875)	1.99862313
67	Hyperphosphatemia (HP:0002905)	1.99749250
68	Supernumerary bones of the axial skeleton (HP:0009144)	1.99491402
69	Increased serum pyruvate (HP:0003542)	1.99127777
70	Pelvic girdle muscle weakness (HP:0003749)	1.98831595
71	Optic nerve hypoplasia (HP:0000609)	1.97882865
72	Macrocytic anemia (HP:0001972)	1.94624131
73	Diastasis recti (HP:0001540)	1.93409567
74	Genital tract atresia (HP:0001827)	1.92789442
75	Abnormality of the septum pellucidum (HP:0007375)	1.92592968
76	Anophthalmia (HP:0000528)	1.92507951
77	Abnormality of glycolysis (HP:0004366)	1.91937688
78	Congenital, generalized hypertrichosis (HP:0004540)	1.90232059
79	Long foot (HP:0001833)	1.89752382
80	Stomach cancer (HP:0012126)	1.89496179
81	Abnormal number of erythroid precursors (HP:0012131)	1.88395067
82	Methylmalonic acidemia (HP:0002912)	1.88105129
83	Cystic liver disease (HP:0006706)	1.88000231
84	Abnormality of glycine metabolism (HP:0010895)	1.87154015
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87154015
86	Supernumerary ribs (HP:0005815)	1.85573247
87	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.85196814
88	Lethargy (HP:0001254)	1.85162578
89	Nephronophthisis (HP:0000090)	1.84043023
90	Entropion (HP:0000621)	1.82832850
91	Hyperglycinuria (HP:0003108)	1.82003359
92	Shoulder girdle muscle weakness (HP:0003547)	1.81312506
93	Median cleft lip (HP:0000161)	1.80144905
94	Partial agenesis of the corpus callosum (HP:0001338)	1.79640163
95	Rectal fistula (HP:0100590)	1.79371167
96	Rectovaginal fistula (HP:0000143)	1.79371167
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.78408697
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78408697
99	Sclerocornea (HP:0000647)	1.77490234
100	Hyperphosphaturia (HP:0003109)	1.76913834

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	7.02033534
2	MAP4K1	3.88476073
3	LIMK1	3.37321518
4	BCKDK	3.36337871
5	MAPKAPK3	3.14863641
6	FGFR2	2.89386434
7	ADRBK1	2.48783083
8	MST4	2.43718923
9	OXSR1	2.39705939
10	CDK19	2.21269894
11	MAP3K4	2.16406511
12	DYRK2	2.16008088
13	WNK4	2.12660260
14	MAP2K7	2.06174814
15	TLK1	2.01136458
16	BMPR1B	1.97951375
17	CAMKK2	1.96770629
18	PASK	1.93168563
19	MAP2K4	1.86513805
20	EPHA2	1.82163348
21	MAP3K5	1.80855790
22	TAOK2	1.75773540
23	MAP3K11	1.74903706
24	CAMKK1	1.56715591
25	EPHA3	1.53472391
26	CSF1R	1.52895338
27	NME1	1.46595042
28	TNIK	1.37594084
29	PIK3CG	1.35083212
30	SCYL2	1.32150213
31	TESK2	1.27972558
32	MAP4K2	1.26737021
33	DAPK1	1.24331800
34	GRK1	1.23286628
35	TESK1	1.22692082
36	PAK6	1.21976708
37	TGFBR1	1.14315680
38	STK39	1.13440978
39	BCR	1.08188580
40	PRPF4B	1.07863660
41	KDR	1.00155754
42	MYLK	0.95679070
43	ACVR1B	0.90124005
44	WNK3	0.88164047
45	FRK	0.82621507
46	CAMK2B	0.79901983
47	ERBB3	0.77148411
48	PBK	0.73927139
49	AKT3	0.72742626
50	MINK1	0.71890088
51	PDK1	0.69691849
52	FLT3	0.69468528
53	MAPK13	0.61884563
54	PKN2	0.60058782
55	PDK2	0.59513224
56	CAMK2D	0.59339870
57	PRKCQ	0.58397302
58	CAMK2G	0.56860552
59	ILK	0.54517334
60	PIM2	0.53324169
61	MAPK15	0.51718571
62	CSNK1G3	0.51062504
63	VRK2	0.51006109
64	PAK3	0.50782556
65	RPS6KB2	0.48355280
66	INSRR	0.47773971
67	DAPK3	0.46260949
68	TAOK3	0.44026392
69	CSNK1G1	0.43826501
70	CAMK1G	0.41995362
71	STK38L	0.40724930
72	STK4	0.40389168
73	TRIM28	0.39382893
74	CAMK2A	0.38331587
75	CSNK1G2	0.36808858
76	BMPR2	0.36418874
77	STK3	0.35772999
78	ERBB2	0.35169029
79	ADRBK2	0.35124791
80	PRKCE	0.33742809
81	FGFR1	0.33559499
82	CSNK1A1L	0.33005226
83	CAMK1	0.30914470
84	PRKD1	0.29636460
85	PNCK	0.27945842
86	CASK	0.27571399
87	EGFR	0.26783717
88	SRPK1	0.25541656
89	EPHA4	0.24757280
90	LMTK2	0.23816492
91	LCK	0.23218125
92	ABL2	0.22758500
93	PLK2	0.22361354
94	ERBB4	0.22048274
95	CAMK1D	0.19973817
96	GRK5	0.17362905
97	PRKCA	0.16985869
98	LRRK2	0.16141023
99	IRAK4	0.15832736
100	RPS6KA5	0.15807835

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	6.37784686
2	Ribosome_Homo sapiens_hsa03010	3.49694954
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.37948723
4	Proteasome_Homo sapiens_hsa03050	3.25514215
5	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	3.05363902
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.86594870
7	Parkinsons disease_Homo sapiens_hsa05012	2.51797678
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.50933878
9	Nicotine addiction_Homo sapiens_hsa05033	2.48303351
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.16803288
11	RNA polymerase_Homo sapiens_hsa03020	2.00293203
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92915880
13	Mineral absorption_Homo sapiens_hsa04978	1.91421599
14	Protein export_Homo sapiens_hsa03060	1.90223440
15	Huntingtons disease_Homo sapiens_hsa05016	1.74349497
16	Alzheimers disease_Homo sapiens_hsa05010	1.70719569
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.70084717
18	Sulfur metabolism_Homo sapiens_hsa00920	1.69773841
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.65802353
20	Basal cell carcinoma_Homo sapiens_hsa05217	1.65029723
21	Purine metabolism_Homo sapiens_hsa00230	1.46371193
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43279445
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.36363607
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32168844
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23295579
26	Circadian rhythm_Homo sapiens_hsa04710	1.20593470
27	Pancreatic secretion_Homo sapiens_hsa04972	1.16838706
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16668998
29	Propanoate metabolism_Homo sapiens_hsa00640	1.16077158
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.12425344
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.09850014
32	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09835498
33	Mismatch repair_Homo sapiens_hsa03430	1.08422099
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07902700
35	Sulfur relay system_Homo sapiens_hsa04122	0.98548522
36	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.97552040
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93581320
38	Regulation of autophagy_Homo sapiens_hsa04140	0.90303945
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89933821
40	Homologous recombination_Homo sapiens_hsa03440	0.88244463
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87634800
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.87319596
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85002719
44	Circadian entrainment_Homo sapiens_hsa04713	0.83388051
45	Protein digestion and absorption_Homo sapiens_hsa04974	0.79816482
46	GABAergic synapse_Homo sapiens_hsa04727	0.76527366
47	ABC transporters_Homo sapiens_hsa02010	0.75518591
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74512020
49	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.74384329
50	Fatty acid elongation_Homo sapiens_hsa00062	0.74164245
51	Cocaine addiction_Homo sapiens_hsa05030	0.73679625
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72603465
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72071650
54	Shigellosis_Homo sapiens_hsa05131	0.71106931
55	RNA degradation_Homo sapiens_hsa03018	0.68945858
56	Olfactory transduction_Homo sapiens_hsa04740	0.68802504
57	Morphine addiction_Homo sapiens_hsa05032	0.68429985
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.67459715
59	Metabolic pathways_Homo sapiens_hsa01100	0.66712835
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64874741
61	Taste transduction_Homo sapiens_hsa04742	0.63985630
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.62847372
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.62087048
64	Renin-angiotensin system_Homo sapiens_hsa04614	0.61712321
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61517347
66	Peroxisome_Homo sapiens_hsa04146	0.59115139
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.56443027
68	Salivary secretion_Homo sapiens_hsa04970	0.56041221
69	Amphetamine addiction_Homo sapiens_hsa05031	0.55494579
70	Butanoate metabolism_Homo sapiens_hsa00650	0.54931104
71	Wnt signaling pathway_Homo sapiens_hsa04310	0.54544875
72	Retinol metabolism_Homo sapiens_hsa00830	0.53864904
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53031346
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51681308
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50814177
76	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.50480082
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49968771
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47691343
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47090827
80	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.43876263
81	Base excision repair_Homo sapiens_hsa03410	0.42454196
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39691216
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39090887
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33279769
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.32335708
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31002040
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30372316
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.28967336
89	Serotonergic synapse_Homo sapiens_hsa04726	0.25322892
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24670546
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24217494
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.24168150
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23172623
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22559257
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.22306381
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.21998111
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.21500255
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20907313
99	Insulin secretion_Homo sapiens_hsa04911	0.19208482
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.18940268

KRT8P30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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