KRT8P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene biosynthetic process (GO:0019370)8.89856682
2leukotriene metabolic process (GO:0006691)6.97358287
3glutathione metabolic process (GO:0006749)6.06251032
4fatty acid derivative biosynthetic process (GO:1901570)5.67899699
5icosanoid biosynthetic process (GO:0046456)5.67899699
6peptide catabolic process (GO:0043171)5.45582174
7GDP-mannose metabolic process (GO:0019673)5.32113289
8unsaturated fatty acid biosynthetic process (GO:0006636)4.62758217
9NADH metabolic process (GO:0006734)4.45322931
10cysteine metabolic process (GO:0006534)4.29738329
11glutathione biosynthetic process (GO:0006750)4.13975955
12regulation of guanylate cyclase activity (GO:0031282)4.08140772
13mitochondrial calcium ion transport (GO:0006851)4.08024164
14dopamine transport (GO:0015872)4.06390936
15glutathione derivative biosynthetic process (GO:1901687)4.02851240
16glutathione derivative metabolic process (GO:1901685)4.02851240
17detection of molecule of bacterial origin (GO:0032490)4.01616197
18nonribosomal peptide biosynthetic process (GO:0019184)3.90632255
19icosanoid metabolic process (GO:0006690)3.89556533
20fatty acid derivative metabolic process (GO:1901568)3.89556533
21regulation of oxidative phosphorylation (GO:0002082)3.85773130
22proteasome assembly (GO:0043248)3.83304332
23angiotensin maturation (GO:0002003)3.83296492
24bundle of His cell to Purkinje myocyte communication (GO:0086069)3.74630684
25xenobiotic catabolic process (GO:0042178)3.64204728
26calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.63299989
27antibacterial humoral response (GO:0019731)3.61505855
28phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.57304533
29viral mRNA export from host cell nucleus (GO:0046784)3.55512895
30unsaturated fatty acid metabolic process (GO:0033559)3.50974462
31eosinophil chemotaxis (GO:0048245)3.49158285
32antimicrobial humoral response (GO:0019730)3.49000866
33peptide metabolic process (GO:0006518)3.37699806
34fructose metabolic process (GO:0006000)3.26569347
35positive regulation of guanylate cyclase activity (GO:0031284)3.21493674
36epoxygenase P450 pathway (GO:0019373)3.20947573
37carbohydrate phosphorylation (GO:0046835)3.20117983
38regulation of cellular amino acid metabolic process (GO:0006521)3.18222400
39hepatocyte apoptotic process (GO:0097284)3.18133553
40artery smooth muscle contraction (GO:0014824)3.17597536
41protein retention in ER lumen (GO:0006621)3.14631231
42daunorubicin metabolic process (GO:0044597)3.12886448
43polyketide metabolic process (GO:0030638)3.12886448
44doxorubicin metabolic process (GO:0044598)3.12886448
45L-ascorbic acid metabolic process (GO:0019852)3.12801314
46eosinophil migration (GO:0072677)3.09712829
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04705784
48regulation of metalloenzyme activity (GO:0048552)3.04252655
49positive regulation of pseudopodium assembly (GO:0031274)3.02603927
50regulation of mitochondrial translation (GO:0070129)2.99213710
51nucleotide-sugar biosynthetic process (GO:0009226)2.95649161
52regulation of vitamin metabolic process (GO:0030656)2.94845168
53energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94806683
54ATP synthesis coupled proton transport (GO:0015986)2.94806683
55cyclooxygenase pathway (GO:0019371)2.89782343
56peptide biosynthetic process (GO:0043043)2.84859377
57regulation of bile acid biosynthetic process (GO:0070857)2.81708167
58digestion (GO:0007586)2.81685268
59positive regulation of glycoprotein metabolic process (GO:1903020)2.80449955
60protein maturation by protein folding (GO:0022417)2.79917178
61negative regulation of epidermal cell differentiation (GO:0045605)2.79365951
62intestinal absorption (GO:0050892)2.79272435
63positive regulation of cellular amine metabolic process (GO:0033240)2.78140047
64positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77989938
65cobalamin metabolic process (GO:0009235)2.77903506
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77655296
67galactose catabolic process (GO:0019388)2.76273483
68aminoglycoside antibiotic metabolic process (GO:0030647)2.75382641
69synaptic transmission, dopaminergic (GO:0001963)2.74332044
70very-low-density lipoprotein particle assembly (GO:0034379)2.73550105
71regulation of cellular amine metabolic process (GO:0033238)2.70864657
72regulation of cellular extravasation (GO:0002691)2.68003738
73regulation of interleukin-6 biosynthetic process (GO:0045408)2.67982367
74regulation of pseudopodium assembly (GO:0031272)2.65563536
75GTP biosynthetic process (GO:0006183)2.65387581
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65052084
77glycoside metabolic process (GO:0016137)2.62848868
78macrophage activation (GO:0042116)2.62618407
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62096436
80oligosaccharide catabolic process (GO:0009313)2.61649119
81prostanoid biosynthetic process (GO:0046457)2.61612506
82prostaglandin biosynthetic process (GO:0001516)2.61612506
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61002856
84response to copper ion (GO:0046688)2.59302623
85regulation of cellular respiration (GO:0043457)2.58527383
86nucleoside diphosphate biosynthetic process (GO:0009133)2.58118717
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57927422
88tonic smooth muscle contraction (GO:0014820)2.57655964
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57369765
90regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.57266549
91regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.57266549
92prostanoid metabolic process (GO:0006692)2.54557870
93prostaglandin metabolic process (GO:0006693)2.54557870
94disruption of cells of other organism (GO:0044364)2.53377054
95killing of cells of other organism (GO:0031640)2.53377054
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52615440
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52615440
98regulation of systemic arterial blood pressure by hormone (GO:0001990)2.51900647
99regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.51900647
100endocrine process (GO:0050886)2.51900647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.34788048
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.75689586
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.85693481
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70447024
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.38422454
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.81877057
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.52217737
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.42808154
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38322188
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34620011
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33577103
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.33015055
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27399550
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13949860
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02965385
16GATA6_25053715_ChIP-Seq_YYC3_Human1.97824012
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90629589
18GATA4_25053715_ChIP-Seq_YYC3_Human1.88003886
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78739764
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77442201
21PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.71302941
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70664187
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64498226
24DCP1A_22483619_ChIP-Seq_HELA_Human1.62122524
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61261001
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57111752
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53863374
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52695147
29SOX2_20726797_ChIP-Seq_SW620_Human1.50882687
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50357916
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.49944754
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49817470
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48688148
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47706003
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.42681586
36IRF1_19129219_ChIP-ChIP_H3396_Human1.41383441
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41099652
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40957913
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.36035904
40VDR_23849224_ChIP-Seq_CD4+_Human1.34389809
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33944813
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31831607
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.30732427
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.28164368
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26894551
46CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23449178
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.23072999
48PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21778626
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20743220
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19539574
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18096348
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18090390
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17852849
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15207382
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14582104
56STAT1_20625510_ChIP-Seq_HELA_Human1.11515483
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.09527172
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.08892314
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.07746794
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07706517
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07672489
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06777148
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04085219
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03848607
65P300_27268052_Chip-Seq_Bcells_Human1.02775523
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02436525
67EGR1_19032775_ChIP-ChIP_M12_Human1.02365373
68FOXP3_21729870_ChIP-Seq_TREG_Human1.01787229
69BCL6_27268052_Chip-Seq_Bcells_Human0.98885603
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98520327
71NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97737662
72OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97482524
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97299515
74SOX2_21211035_ChIP-Seq_LN229_Human0.95122027
75AR_21909140_ChIP-Seq_LNCAP_Human0.94554721
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94531865
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.93953618
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93948359
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93400812
80ELF5_23300383_ChIP-Seq_T47D_Human0.93158446
81ERG_20517297_ChIP-Seq_VCAP_Human0.92970182
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92965221
83MYB_26560356_Chip-Seq_TH2_Human0.92824768
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92732015
85SA1_27219007_Chip-Seq_Bcells_Human0.91804555
86NANOG_20526341_ChIP-Seq_ESCs_Human0.91030514
87BCOR_27268052_Chip-Seq_Bcells_Human0.90319025
88GABP_19822575_ChIP-Seq_HepG2_Human0.89734140
89ATF3_27146783_Chip-Seq_COLON_Human0.89261462
90LXR_22158963_ChIP-Seq_LIVER_Mouse0.89036930
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88262834
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.88262834
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88122959
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87761813
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87717348
96XRN2_22483619_ChIP-Seq_HELA_Human0.86988949
97CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86933823
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86770522
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86658303
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86347361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism7.29127145
2MP0005360_urolithiasis4.83925368
3MP0002163_abnormal_gland_morphology4.72137677
4MP0002139_abnormal_hepatobiliary_system4.03746068
5MP0001666_abnormal_nutrient_absorption3.33526917
6MP0004019_abnormal_vitamin_homeostasis3.20582446
7MP0005379_endocrine/exocrine_gland_phen3.05923122
8MP0003806_abnormal_nucleotide_metabolis2.81579037
9MP0005085_abnormal_gallbladder_physiolo2.61436954
10MP0009379_abnormal_foot_pigmentation2.54904660
11MP0004264_abnormal_extraembryonic_tissu2.43921362
12MP0003693_abnormal_embryo_hatching2.21523572
13MP0005365_abnormal_bile_salt2.21187601
14MP0010234_abnormal_vibrissa_follicle2.16273365
15MP0003195_calcinosis2.02333719
16MP0005451_abnormal_body_composition1.99797715
17MP0008260_abnormal_autophagy1.89993817
18MP0003191_abnormal_cellular_cholesterol1.87139622
19MP0001764_abnormal_homeostasis1.87138444
20MP0010155_abnormal_intestine_physiology1.86383279
21MP0009785_altered_susceptibility_to1.84455183
22MP0000613_abnormal_salivary_gland1.79242023
23MP0004147_increased_porphyrin_level1.77676975
24MP0002277_abnormal_respiratory_mucosa1.74419119
25MP0008872_abnormal_physiological_respon1.70990241
26MP0003252_abnormal_bile_duct1.67649648
27MP0006082_CNS_inflammation1.53823412
28MP0001756_abnormal_urination1.53090086
29MP0005220_abnormal_exocrine_pancreas1.48537324
30MP0005584_abnormal_enzyme/coenzyme_acti1.46554105
31MP0009333_abnormal_splenocyte_physiolog1.35739315
32MP0005332_abnormal_amino_acid1.33975150
33MP0008875_abnormal_xenobiotic_pharmacok1.33562469
34MP0002796_impaired_skin_barrier1.31409787
35MP0009840_abnormal_foam_cell1.31070367
36MP0003724_increased_susceptibility_to1.30664110
37MP0003866_abnormal_defecation1.30325086
38MP0002089_abnormal_postnatal_growth/wei1.29472257
39MP0003959_abnormal_lean_body1.28574925
40MP0009643_abnormal_urine_homeostasis1.26880939
41MP0006054_spinal_hemorrhage1.25892549
42MP0005319_abnormal_enzyme/_coenzyme1.24927849
43MP0000538_abnormal_urinary_bladder1.22323427
44MP0004957_abnormal_blastocyst_morpholog1.21319008
45MP0005166_decreased_susceptibility_to1.21296014
46MP0001845_abnormal_inflammatory_respons1.13390790
47MP0001873_stomach_inflammation1.11824147
48MP0002148_abnormal_hypersensitivity_rea1.09659738
49MP0005058_abnormal_lysosome_morphology1.08870986
50MP0000490_abnormal_crypts_of1.08073273
51MP0005025_abnormal_response_to1.08055144
52MP0008469_abnormal_protein_level1.07866427
53MP0009764_decreased_sensitivity_to1.07570123
54MP0001664_abnormal_digestion1.04608002
55MP0010386_abnormal_urinary_bladder1.04201214
56MP0003300_gastrointestinal_ulcer1.03954362
57MP0000537_abnormal_urethra_morphology1.03384284
58MP0005670_abnormal_white_adipose1.02321566
59MP0002822_catalepsy1.01196003
60MP0001765_abnormal_ion_homeostasis1.01157278
61MP0005636_abnormal_mineral_homeostasis1.00808978
62MP0002138_abnormal_hepatobiliary_system1.00595859
63MP0001800_abnormal_humoral_immune0.98518145
64MP0001663_abnormal_digestive_system0.96791119
65MP0003718_maternal_effect0.95634444
66MP0010329_abnormal_lipoprotein_level0.95611208
67MP0008004_abnormal_stomach_pH0.91296955
68MP0001835_abnormal_antigen_presentation0.88542902
69MP0002736_abnormal_nociception_after0.88509263
70MP0002136_abnormal_kidney_physiology0.87285693
71MP0003186_abnormal_redox_activity0.87105182
72MP0002102_abnormal_ear_morphology0.84419372
73MP0006035_abnormal_mitochondrial_morpho0.84185464
74MP0003315_abnormal_perineum_morphology0.82087067
75MP0000477_abnormal_intestine_morphology0.81871687
76MP0000858_altered_metastatic_potential0.79622446
77MP0002452_abnormal_antigen_presenting0.79334702
78MP0002723_abnormal_immune_serum0.78659722
79MP0010352_gastrointestinal_tract_polyps0.77396433
80MP0005408_hypopigmentation0.74502477
81MP0000609_abnormal_liver_physiology0.70609083
82MP0005000_abnormal_immune_tolerance0.68558786
83MP0005376_homeostasis/metabolism_phenot0.67357176
84MP0002118_abnormal_lipid_homeostasis0.65784743
85MP0001819_abnormal_immune_cell0.64621228
86MP0001853_heart_inflammation0.64383034
87MP0003878_abnormal_ear_physiology0.64007111
88MP0005377_hearing/vestibular/ear_phenot0.64007111
89MP0002166_altered_tumor_susceptibility0.63952991
90MP0000516_abnormal_urinary_system0.63242883
91MP0005367_renal/urinary_system_phenotyp0.63242883
92MP0002420_abnormal_adaptive_immunity0.62182146
93MP0006036_abnormal_mitochondrial_physio0.61777413
94MP0005666_abnormal_adipose_tissue0.61712351
95MP0000015_abnormal_ear_pigmentation0.60833226
96MP0005381_digestive/alimentary_phenotyp0.59809848
97MP0005501_abnormal_skin_physiology0.59804120
98MP0002006_tumorigenesis0.59754758
99MP0002419_abnormal_innate_immunity0.58795288
100MP0005167_abnormal_blood-brain_barrier0.58266289

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.44681864
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.44681864
3Abnormality of glycolipid metabolism (HP:0010969)6.44681864
4J-shaped sella turcica (HP:0002680)6.19781467
5Carpal bone hypoplasia (HP:0001498)5.13786451
6Vertebral arch anomaly (HP:0008438)4.87814979
7Diastasis recti (HP:0001540)4.59940110
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02250080
9Thoracolumbar scoliosis (HP:0002944)3.95423122
10Flat acetabular roof (HP:0003180)3.88352862
11Abnormality of the lumbar spine (HP:0100712)3.75104068
12Nausea (HP:0002018)3.74089129
13Deformed sella turcica (HP:0002681)3.65757988
14Mucopolysacchariduria (HP:0008155)3.64388301
15Urinary glycosaminoglycan excretion (HP:0003541)3.64388301
16Beaking of vertebral bodies (HP:0004568)3.61744934
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.54364913
18Dysostosis multiplex (HP:0000943)3.53926032
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.44454054
20Abnormality of polysaccharide metabolism (HP:0011012)3.44454054
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.44454054
22Flared iliac wings (HP:0002869)3.42183881
23Broad alveolar ridges (HP:0000187)3.19806186
24Thoracic kyphosis (HP:0002942)3.18056730
25Recurrent bronchitis (HP:0002837)3.14632824
26Orthostatic hypotension (HP:0001278)3.01402407
27Abnormality of proline metabolism (HP:0010907)2.89733423
28Hydroxyprolinuria (HP:0003080)2.89733423
29Death in childhood (HP:0003819)2.76117959
30Tongue fasciculations (HP:0001308)2.73400957
31Broad ribs (HP:0000885)2.73015002
32Aortic regurgitation (HP:0001659)2.66236242
33Protuberant abdomen (HP:0001538)2.62815192
34Thickened calvaria (HP:0002684)2.60180166
35Fat malabsorption (HP:0002630)2.59821225
36Malnutrition (HP:0004395)2.59411371
37Abnormality of the sella turcica (HP:0002679)2.57985816
38Hepatocellular necrosis (HP:0001404)2.45331858
39Ileus (HP:0002595)2.44736339
40Hepatic necrosis (HP:0002605)2.43365422
41Abdominal distention (HP:0003270)2.41407312
42Abnormality of urine glucose concentration (HP:0011016)2.40021273
43Glycosuria (HP:0003076)2.40021273
44Proximal tubulopathy (HP:0000114)2.35257520
45Mitochondrial inheritance (HP:0001427)2.30543096
46Muscle fibrillation (HP:0010546)2.28753218
47Pathologic fracture (HP:0002756)2.18784095
48Type I transferrin isoform profile (HP:0003642)2.12588755
49Abnormal mitochondria in muscle tissue (HP:0008316)2.12513824
50Progressive neurologic deterioration (HP:0002344)2.12473931
51Prolonged neonatal jaundice (HP:0006579)2.11526701
52Hypoplasia of the odontoid process (HP:0003311)2.09786106
53Microretrognathia (HP:0000308)2.09549869
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09371881
55Chronic diarrhea (HP:0002028)2.08515895
56Acute necrotizing encephalopathy (HP:0006965)2.07931984
57Increased CSF lactate (HP:0002490)2.07722297
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07430351
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07430351
60Recurrent pneumonia (HP:0006532)2.04859842
61Renal tubular acidosis (HP:0001947)2.04784148
62Abnormality of the thoracic spine (HP:0100711)2.04272995
63Abnormality of the alveolar ridges (HP:0006477)2.03481525
64Slow saccadic eye movements (HP:0000514)1.99287173
65Acute encephalopathy (HP:0006846)1.97788178
66Anomalous pulmonary venous return (HP:0010772)1.97060962
67Pancreatitis (HP:0001733)1.95660702
68Vascular calcification (HP:0004934)1.95211007
69Steatorrhea (HP:0002570)1.94611854
70Systemic lupus erythematosus (HP:0002725)1.94187115
71Abnormality of the odontoid process (HP:0003310)1.93494088
72Bronchitis (HP:0012387)1.92976089
73Dysautonomia (HP:0002459)1.91037183
74Wide intermamillary distance (HP:0006610)1.90985690
75Late onset (HP:0003584)1.88392650
76Severe global developmental delay (HP:0011344)1.85888783
77Lethargy (HP:0001254)1.82962288
78Rough bone trabeculation (HP:0100670)1.82695743
79Ovoid vertebral bodies (HP:0003300)1.81240713
80Hypobetalipoproteinemia (HP:0003563)1.80173010
81Increased muscle lipid content (HP:0009058)1.80143653
82Cerebral edema (HP:0002181)1.79407296
83Abnormality of the pulmonary veins (HP:0011718)1.77871447
84Hoarse voice (HP:0001609)1.76531019
85Abnormal trabecular bone morphology (HP:0100671)1.76332491
86Increased intramyocellular lipid droplets (HP:0012240)1.75681485
87Intrahepatic cholestasis (HP:0001406)1.75457426
88Renal tubular dysfunction (HP:0000124)1.75005692
89Amyloidosis (HP:0011034)1.73365711
90Dicarboxylic aciduria (HP:0003215)1.71593816
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71593816
92Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69427076
93Acne (HP:0001061)1.69411616
94Hypotension (HP:0002615)1.69358517
95Palpebral edema (HP:0100540)1.68848302
96Abnormal autonomic nervous system physiology (HP:0012332)1.66384727
97Lactic acidosis (HP:0003128)1.65045371
98Hyperuricemia (HP:0002149)1.64728481
99Increased purine levels (HP:0004368)1.64728481
100Conjugated hyperbilirubinemia (HP:0002908)1.63980153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.07148146
2BLK3.92323533
3GRK63.08466601
4CAMKK22.83412565
5MST42.78442307
6TESK12.77468269
7TESK22.74620728
8VRK22.60084970
9ACVR1B2.58088579
10NME22.57402655
11MST1R2.55269312
12TAF12.52463046
13MAP3K122.44608325
14PDK22.14776203
15BCKDK2.03778007
16LMTK21.87685045
17ERN11.73578729
18SCYL21.66363004
19BUB11.58421522
20EIF2AK11.55910445
21TBK11.55910303
22RIPK11.44431073
23GRK51.43360647
24FRK1.42622917
25BRSK21.40283230
26MAP3K31.39468292
27TXK1.39029179
28NME11.36818202
29RIPK41.34089567
30RPS6KB21.34002302
31TYK21.33880750
32IKBKE1.29495509
33IRAK31.28400415
34STK41.28226401
35KDR1.22656734
36ABL21.20555453
37PBK1.18199434
38IRAK21.16769375
39TLK11.13346803
40DAPK11.09572829
41MAP3K21.08857793
42LIMK11.05922465
43PAK41.03132566
44PTK2B1.02556814
45BRSK10.97870355
46VRK10.97138047
47MYLK0.94230567
48MAP3K110.86280272
49PRPF4B0.85035617
50DAPK30.84918393
51GRK10.84046381
52PRKG20.81407544
53PIM20.78510005
54TAOK20.76173301
55CAMK40.76026970
56MAP3K10.74175443
57MATK0.73276294
58IKBKB0.68906121
59BMPR20.68143622
60TAOK30.67668032
61RPS6KA40.66410765
62IRAK40.65471633
63STK160.60443474
64MAP2K30.59762160
65FGR0.58447361
66AURKB0.57499845
67DAPK20.56703856
68IRAK10.55636737
69CAMK2D0.55618441
70STK100.55574071
71PIM10.54402927
72CAMK2G0.53910253
73MAP4K20.53094627
74CAMK2B0.52944062
75TNIK0.50172564
76YES10.49350993
77OXSR10.47777659
78RPS6KA50.46992491
79FES0.45275862
80TRIM280.44064511
81LYN0.43357793
82ADRBK10.43311789
83CSNK1G30.43151331
84MET0.43067296
85MAP3K80.42247908
86ADRBK20.41549141
87CSNK1A1L0.39760330
88EIF2AK30.39582781
89ZAK0.37847726
90LRRK20.37540328
91MAP2K20.37187197
92CDK190.37067839
93GRK70.35985673
94PLK10.34948627
95CHUK0.33284315
96FER0.33161884
97SYK0.29141617
98PRKCA0.26127376
99CSNK1A10.25960500
100STK390.25780678

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.99458966
2Proteasome_Homo sapiens_hsa030503.76206683
3Fat digestion and absorption_Homo sapiens_hsa049752.87530340
4Vitamin digestion and absorption_Homo sapiens_hsa049772.78859332
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.58182891
6Glutathione metabolism_Homo sapiens_hsa004802.56790307
7Fructose and mannose metabolism_Homo sapiens_hsa000512.31473928
8Oxidative phosphorylation_Homo sapiens_hsa001902.05251469
9Renin-angiotensin system_Homo sapiens_hsa046141.98837253
10Parkinsons disease_Homo sapiens_hsa050121.88137457
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.87731152
12Sulfur metabolism_Homo sapiens_hsa009201.75237372
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68353271
14Chemical carcinogenesis_Homo sapiens_hsa052041.62130667
15Fatty acid elongation_Homo sapiens_hsa000621.59746561
16Galactose metabolism_Homo sapiens_hsa000521.59468656
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57540664
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56066393
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51093742
20Arachidonic acid metabolism_Homo sapiens_hsa005901.38938273
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35834206
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32248205
23Mineral absorption_Homo sapiens_hsa049781.32221372
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29313026
25Alzheimers disease_Homo sapiens_hsa050101.27851740
26Protein digestion and absorption_Homo sapiens_hsa049741.24987719
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.23760810
28Pyrimidine metabolism_Homo sapiens_hsa002401.22882030
29Arginine biosynthesis_Homo sapiens_hsa002201.22293197
30Huntingtons disease_Homo sapiens_hsa050161.19401091
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18792431
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.11937836
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11557145
34DNA replication_Homo sapiens_hsa030301.11087865
35Systemic lupus erythematosus_Homo sapiens_hsa053221.08965439
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07012460
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05883568
38Asthma_Homo sapiens_hsa053101.02657780
39Histidine metabolism_Homo sapiens_hsa003400.97020227
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95794745
41Vibrio cholerae infection_Homo sapiens_hsa051100.94330568
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94261796
43Folate biosynthesis_Homo sapiens_hsa007900.93945957
44Sulfur relay system_Homo sapiens_hsa041220.93263818
45Pancreatic secretion_Homo sapiens_hsa049720.92445353
46Ribosome_Homo sapiens_hsa030100.92259966
47Pentose phosphate pathway_Homo sapiens_hsa000300.92259701
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90992542
49Phenylalanine metabolism_Homo sapiens_hsa003600.90824947
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89684197
51Glycerolipid metabolism_Homo sapiens_hsa005610.89662902
52Retinol metabolism_Homo sapiens_hsa008300.86705954
53RNA polymerase_Homo sapiens_hsa030200.84252428
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.83484737
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83079730
56Starch and sucrose metabolism_Homo sapiens_hsa005000.83067217
57Tryptophan metabolism_Homo sapiens_hsa003800.82983979
58Fatty acid degradation_Homo sapiens_hsa000710.80833938
59Caffeine metabolism_Homo sapiens_hsa002320.76474315
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.74399593
61Rheumatoid arthritis_Homo sapiens_hsa053230.74395044
62Mismatch repair_Homo sapiens_hsa034300.72383023
63Lysosome_Homo sapiens_hsa041420.71033188
64Leishmaniasis_Homo sapiens_hsa051400.70290245
65Tyrosine metabolism_Homo sapiens_hsa003500.67620564
66Peroxisome_Homo sapiens_hsa041460.65773422
67Carbon metabolism_Homo sapiens_hsa012000.65200488
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64624470
69Staphylococcus aureus infection_Homo sapiens_hsa051500.64421176
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63532995
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62554052
72Tuberculosis_Homo sapiens_hsa051520.62178587
73Metabolic pathways_Homo sapiens_hsa011000.61568363
74Collecting duct acid secretion_Homo sapiens_hsa049660.61047391
75Pyruvate metabolism_Homo sapiens_hsa006200.57662910
76Graft-versus-host disease_Homo sapiens_hsa053320.56899485
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54906043
78Base excision repair_Homo sapiens_hsa034100.53284973
79N-Glycan biosynthesis_Homo sapiens_hsa005100.53109086
80Purine metabolism_Homo sapiens_hsa002300.52443680
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.49346236
82Arginine and proline metabolism_Homo sapiens_hsa003300.47494745
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43557242
84Antigen processing and presentation_Homo sapiens_hsa046120.43459216
85Hepatitis C_Homo sapiens_hsa051600.43150995
86Alcoholism_Homo sapiens_hsa050340.41346591
87Protein export_Homo sapiens_hsa030600.40787031
88Biosynthesis of amino acids_Homo sapiens_hsa012300.40356155
89Legionellosis_Homo sapiens_hsa051340.39935508
90Allograft rejection_Homo sapiens_hsa053300.39758779
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39202337
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38351767
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36820351
94Bile secretion_Homo sapiens_hsa049760.34468525
95Salmonella infection_Homo sapiens_hsa051320.34369038
96Sphingolipid metabolism_Homo sapiens_hsa006000.33580457
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33485887
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32740518
99Autoimmune thyroid disease_Homo sapiens_hsa053200.31402829
100Amphetamine addiction_Homo sapiens_hsa050310.31214160

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