ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of guanylate cyclase activity (GO:0031282)	6.55513345
2	NADH metabolic process (GO:0006734)	6.50946631
3	antibacterial humoral response (GO:0019731)	6.03857066
4	antimicrobial humoral response (GO:0019730)	5.69016361
5	positive regulation of pseudopodium assembly (GO:0031274)	5.68215672
6	positive regulation of guanylate cyclase activity (GO:0031284)	5.40035877
7	fructose metabolic process (GO:0006000)	5.16208242
8	regulation of pseudopodium assembly (GO:0031272)	5.03456862
9	angiotensin maturation (GO:0002003)	4.91625126
10	GDP-mannose metabolic process (GO:0019673)	4.89865423
11	glutathione metabolic process (GO:0006749)	4.71835148
12	negative regulation of epidermal cell differentiation (GO:0045605)	4.62032806
13	intestinal absorption (GO:0050892)	4.53409077
14	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.45191413
15	positive regulation of respiratory burst (GO:0060267)	4.39101339
16	leukotriene biosynthetic process (GO:0019370)	4.37888842
17	cobalamin metabolic process (GO:0009235)	4.31785058
18	glutathione derivative biosynthetic process (GO:1901687)	4.15393668
19	glutathione derivative metabolic process (GO:1901685)	4.15393668
20	epoxygenase P450 pathway (GO:0019373)	4.10403674
21	eosinophil chemotaxis (GO:0048245)	3.96049737
22	leukotriene metabolic process (GO:0006691)	3.96012513
23	regulation of cellular extravasation (GO:0002691)	3.90671284
24	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.90494990
25	endocrine process (GO:0050886)	3.90494990
26	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.90494990
27	digestion (GO:0007586)	3.83318457
28	negative regulation of epidermis development (GO:0045683)	3.83046263
29	nucleoside diphosphate biosynthetic process (GO:0009133)	3.74474361
30	glutathione biosynthetic process (GO:0006750)	3.73018744
31	regulation of cGMP biosynthetic process (GO:0030826)	3.72743414
32	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.65517623
33	proteasome assembly (GO:0043248)	3.61621441
34	regulation of gonadotropin secretion (GO:0032276)	3.57655508
35	nucleotide-sugar biosynthetic process (GO:0009226)	3.51962092
36	urea cycle (GO:0000050)	3.51672453
37	glycolipid catabolic process (GO:0019377)	3.50139582
38	eosinophil migration (GO:0072677)	3.49981469
39	nonribosomal peptide biosynthetic process (GO:0019184)	3.49672757
40	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.49451767
41	regulation of systemic arterial blood pressure (GO:0003073)	3.43681567
42	artery smooth muscle contraction (GO:0014824)	3.39130823
43	icosanoid biosynthetic process (GO:0046456)	3.36717287
44	fatty acid derivative biosynthetic process (GO:1901570)	3.36717287
45	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.36712628
46	vitamin transport (GO:0051180)	3.36488719
47	polyketide metabolic process (GO:0030638)	3.35173526
48	doxorubicin metabolic process (GO:0044598)	3.35173526
49	daunorubicin metabolic process (GO:0044597)	3.35173526
50	chronic inflammatory response (GO:0002544)	3.31263399
51	cyclooxygenase pathway (GO:0019371)	3.31054941
52	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.30773836
53	urea metabolic process (GO:0019627)	3.27857943
54	vitamin transmembrane transport (GO:0035461)	3.27853583
55	regulation of mitochondrial translation (GO:0070129)	3.26242371
56	arginine metabolic process (GO:0006525)	3.22752479
57	xenobiotic catabolic process (GO:0042178)	3.22200193
58	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	3.21809558
59	regulation of cGMP metabolic process (GO:0030823)	3.20483857
60	regulation of triglyceride catabolic process (GO:0010896)	3.19465117
61	fat-soluble vitamin biosynthetic process (GO:0042362)	3.19363278
62	positive regulation of glycoprotein metabolic process (GO:1903020)	3.19265931
63	glomerular filtration (GO:0003094)	3.19155638
64	prostaglandin biosynthetic process (GO:0001516)	3.14933906
65	prostanoid biosynthetic process (GO:0046457)	3.14933906
66	positive regulation of growth hormone secretion (GO:0060124)	3.14484979
67	glycoside metabolic process (GO:0016137)	3.13315519
68	prostanoid metabolic process (GO:0006692)	3.12500505
69	prostaglandin metabolic process (GO:0006693)	3.12500505
70	regulation of bile acid biosynthetic process (GO:0070857)	3.09794372
71	L-ascorbic acid metabolic process (GO:0019852)	3.07499064
72	renal filtration (GO:0097205)	3.06691514
73	aminoglycoside antibiotic metabolic process (GO:0030647)	3.02011319
74	nitrogen cycle metabolic process (GO:0071941)	3.00060928
75	vitamin biosynthetic process (GO:0009110)	2.98395771
76	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.97648149
77	homocysteine metabolic process (GO:0050667)	2.96797028
78	unsaturated fatty acid biosynthetic process (GO:0006636)	2.94965558
79	retina homeostasis (GO:0001895)	2.93967986
80	keratinocyte development (GO:0003334)	2.93445960
81	ATP synthesis coupled proton transport (GO:0015986)	2.93138231
82	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.93138231
83	regulation of keratinocyte proliferation (GO:0010837)	2.92534278
84	peptide metabolic process (GO:0006518)	2.90863564
85	peptide catabolic process (GO:0043171)	2.88884517
86	renal system process involved in regulation of blood volume (GO:0001977)	2.88709369
87	positive regulation of cGMP biosynthetic process (GO:0030828)	2.86464409
88	very-low-density lipoprotein particle assembly (GO:0034379)	2.84961809
89	monosaccharide catabolic process (GO:0046365)	2.83318139
90	fatty acid derivative metabolic process (GO:1901568)	2.82769105
91	icosanoid metabolic process (GO:0006690)	2.82769105
92	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.81618383
93	tonic smooth muscle contraction (GO:0014820)	2.80690151
94	glutamine family amino acid biosynthetic process (GO:0009084)	2.80595660
95	primary alcohol catabolic process (GO:0034310)	2.80424676
96	water-soluble vitamin biosynthetic process (GO:0042364)	2.77428264
97	phasic smooth muscle contraction (GO:0014821)	2.77093634
98	drug metabolic process (GO:0017144)	2.76739225
99	positive regulation of triglyceride lipase activity (GO:0061365)	2.75654374
100	positive regulation of lipoprotein lipase activity (GO:0051006)	2.75654374

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.29556628
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.83553224
3	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.65164633
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.59720942
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.04588837
6	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.98694777
7	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.83414870
8	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.81160514
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.67821789
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40080026
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.32536017
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.32526298
13	AR_21909140_ChIP-Seq_LNCAP_Human	2.26024111
14	GATA4_25053715_ChIP-Seq_YYC3_Human	2.22276102
15	GATA6_25053715_ChIP-Seq_YYC3_Human	2.13209048
16	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.12753311
17	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.11865706
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.11203703
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.10057534
20	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.07229204
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00785820
22	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.97251826
23	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.93848142
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.91742116
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85949455
26	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.81823540
27	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.80065632
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77925072
29	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.76486706
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.73107744
31	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.72801465
32	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.72509118
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71022885
34	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.68385123
35	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.68049374
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.64882959
37	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.61421479
38	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.61302569
39	ZNF263_19887448_ChIP-Seq_K562_Human	1.58539414
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58412098
41	RACK7_27058665_Chip-Seq_MCF-7_Human	1.57987164
42	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.57643084
43	SOX2_20726797_ChIP-Seq_SW620_Human	1.56609107
44	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.50862978
45	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.47001580
46	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.44496967
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44260934
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42397490
49	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.40620149
50	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.38872470
51	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.37220019
52	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36989410
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.35450999
54	XRN2_22483619_ChIP-Seq_HELA_Human	1.33514196
55	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.31710365
56	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.31200047
57	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28776734
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.28558440
59	BCOR_27268052_Chip-Seq_Bcells_Human	1.27523061
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23539443
61	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.22776162
62	SA1_27219007_Chip-Seq_Bcells_Human	1.22717271
63	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.21629041
64	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.19748948
65	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.18250646
66	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.16861024
67	LXR_22292898_ChIP-Seq_THP-1_Human	1.15829333
68	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.15052406
69	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.14488484
70	ATF3_27146783_Chip-Seq_COLON_Human	1.12953086
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12716184
72	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12012825
73	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.09450878
74	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.08801816
75	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08645027
76	PHF8_20622854_ChIP-Seq_HELA_Human	1.07623124
77	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.07590769
78	BCL6_27268052_Chip-Seq_Bcells_Human	1.06759482
79	P68_20966046_ChIP-Seq_HELA_Human	1.06675783
80	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.06357544
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.06291946
82	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.04307707
83	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03885738
84	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.02981147
85	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02327891
86	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.01288098
87	CTCF_27219007_Chip-Seq_Bcells_Human	1.00898370
88	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.99703873
89	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.99000158
90	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.98364987
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.98122813
92	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.98111204
93	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.97784866
94	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.97620706
95	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96696854
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.96415608
97	GABP_19822575_ChIP-Seq_HepG2_Human	0.96276617
98	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.96110225
99	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.96079352
100	SOX2_21211035_ChIP-Seq_LN229_Human	0.95844791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.10051848
2	MP0001666_abnormal_nutrient_absorption	4.99740629
3	MP0002163_abnormal_gland_morphology	4.58563356
4	MP0009379_abnormal_foot_pigmentation	4.38891335
5	MP0010234_abnormal_vibrissa_follicle	4.13438609
6	MP0002139_abnormal_hepatobiliary_system	3.44321002
7	MP0004019_abnormal_vitamin_homeostasis	2.80437160
8	MP0000537_abnormal_urethra_morphology	2.72499834
9	MP0003693_abnormal_embryo_hatching	2.70000723
10	MP0005085_abnormal_gallbladder_physiolo	2.61934494
11	MP0005379_endocrine/exocrine_gland_phen	2.60563269
12	MP0004147_increased_porphyrin_level	2.59758535
13	MP0003718_maternal_effect	2.57530586
14	MP0009840_abnormal_foam_cell	2.52179043
15	MP0004264_abnormal_extraembryonic_tissu	2.49541255
16	MP0003806_abnormal_nucleotide_metabolis	2.43284213
17	MP0010352_gastrointestinal_tract_polyps	2.31595039
18	MP0000462_abnormal_digestive_system	2.31226174
19	MP0005365_abnormal_bile_salt	2.24152909
20	MP0000490_abnormal_crypts_of	2.06255038
21	MP0002796_impaired_skin_barrier	2.00021216
22	MP0010155_abnormal_intestine_physiology	1.88751560
23	MP0002277_abnormal_respiratory_mucosa	1.78377526
24	MP0005332_abnormal_amino_acid	1.77203746
25	MP0005451_abnormal_body_composition	1.77069523
26	MP0002138_abnormal_hepatobiliary_system	1.76549001
27	MP0001188_hyperpigmentation	1.73808532
28	MP0000678_abnormal_parathyroid_gland	1.68631376
29	MP0001664_abnormal_digestion	1.67147719
30	MP0000613_abnormal_salivary_gland	1.64120927
31	MP0003315_abnormal_perineum_morphology	1.55011269
32	MP0000477_abnormal_intestine_morphology	1.54955422
33	MP0002736_abnormal_nociception_after	1.54681614
34	MP0009643_abnormal_urine_homeostasis	1.54606726
35	MP0006292_abnormal_olfactory_placode	1.53793514
36	MP0008872_abnormal_physiological_respon	1.53282097
37	MP0003183_abnormal_peptide_metabolism	1.51490559
38	MP0000538_abnormal_urinary_bladder	1.51120866
39	MP0009697_abnormal_copulation	1.47084266
40	MP0001764_abnormal_homeostasis	1.46748751
41	MP0004957_abnormal_blastocyst_morpholog	1.45299882
42	MP0002098_abnormal_vibrissa_morphology	1.42678474
43	MP0010329_abnormal_lipoprotein_level	1.34066353
44	MP0002822_catalepsy	1.33589497
45	MP0005501_abnormal_skin_physiology	1.22498120
46	MP0008875_abnormal_xenobiotic_pharmacok	1.22288378
47	MP0000566_synostosis	1.19085186
48	MP0002089_abnormal_postnatal_growth/wei	1.09680114
49	MP0003941_abnormal_skin_development	1.09107095
50	MP0002938_white_spotting	1.08212709
51	MP0005636_abnormal_mineral_homeostasis	1.07564857
52	MP0004782_abnormal_surfactant_physiolog	1.07143144
53	MP0003866_abnormal_defecation	1.06268943
54	MP0001663_abnormal_digestive_system	1.05492166
55	MP0000013_abnormal_adipose_tissue	1.03885108
56	MP0005645_abnormal_hypothalamus_physiol	0.99613638
57	MP0005584_abnormal_enzyme/coenzyme_acti	0.98297391
58	MP0005381_digestive/alimentary_phenotyp	0.96733286
59	MP0005084_abnormal_gallbladder_morpholo	0.96399022
60	MP0002876_abnormal_thyroid_physiology	0.95421484
61	MP0001968_abnormal_touch/_nociception	0.95351009
62	MP0005166_decreased_susceptibility_to	0.91871576
63	MP0005409_darkened_coat_color	0.91776608
64	MP0010386_abnormal_urinary_bladder	0.86185499
65	MP0003878_abnormal_ear_physiology	0.85781578
66	MP0005377_hearing/vestibular/ear_phenot	0.85781578
67	MP0010678_abnormal_skin_adnexa	0.82908840
68	MP0001756_abnormal_urination	0.80972954
69	MP0003252_abnormal_bile_duct	0.80694533
70	MP0001765_abnormal_ion_homeostasis	0.79694288
71	MP0000647_abnormal_sebaceous_gland	0.79681245
72	MP0002136_abnormal_kidney_physiology	0.79613455
73	MP0001873_stomach_inflammation	0.78280023
74	MP0001730_embryonic_growth_arrest	0.77195820
75	MP0005670_abnormal_white_adipose	0.76601830
76	MP0005319_abnormal_enzyme/_coenzyme	0.75817439
77	MP0003938_abnormal_ear_development	0.73598437
78	MP0003119_abnormal_digestive_system	0.72607109
79	MP0010771_integument_phenotype	0.71456702
80	MP0000681_abnormal_thyroid_gland	0.71307989
81	MP0001216_abnormal_epidermal_layer	0.70778079
82	MP0002118_abnormal_lipid_homeostasis	0.70048236
83	MP0005083_abnormal_biliary_tract	0.69683601
84	MP0003191_abnormal_cellular_cholesterol	0.68982478
85	MP0002837_dystrophic_cardiac_calcinosis	0.65684826
86	MP0005395_other_phenotype	0.63650964
87	MP0009764_decreased_sensitivity_to	0.62266565
88	MP0003638_abnormal_response/metabolism_	0.62184423
89	MP0003186_abnormal_redox_activity	0.57267228
90	MP0003959_abnormal_lean_body	0.57242771
91	MP0004858_abnormal_nervous_system	0.56917295
92	MP0001727_abnormal_embryo_implantation	0.55794865
93	MP0008004_abnormal_stomach_pH	0.55353597
94	MP0000609_abnormal_liver_physiology	0.55093610
95	MP0003868_abnormal_feces_composition	0.54114519
96	MP0003890_abnormal_embryonic-extraembry	0.53994001
97	MP0001881_abnormal_mammary_gland	0.53671923
98	MP0005058_abnormal_lysosome_morphology	0.53123135
99	MP0003879_abnormal_hair_cell	0.51726305
100	MP0008932_abnormal_embryonic_tissue	0.51195101

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	7.16558610
2	Abnormality of proline metabolism (HP:0010907)	4.66426207
3	Hydroxyprolinuria (HP:0003080)	4.66426207
4	Malnutrition (HP:0004395)	4.59230075
5	Nausea (HP:0002018)	4.39959734
6	Ileus (HP:0002595)	4.11749406
7	Proximal tubulopathy (HP:0000114)	4.06891437
8	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.97760537
9	Abnormality of vitamin B metabolism (HP:0004340)	3.66451879
10	Dicarboxylic aciduria (HP:0003215)	3.64494200
11	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.64494200
12	Glycosuria (HP:0003076)	3.60706049
13	Abnormality of urine glucose concentration (HP:0011016)	3.60706049
14	Confusion (HP:0001289)	3.56518461
15	Hyperglycinemia (HP:0002154)	3.37758101
16	Systemic lupus erythematosus (HP:0002725)	3.36515861
17	Fat malabsorption (HP:0002630)	3.36113119
18	Lethargy (HP:0001254)	3.21704473
19	Hyperammonemia (HP:0001987)	3.21227884
20	Congenital sensorineural hearing impairment (HP:0008527)	3.19690353
21	Abnormality of glycine metabolism (HP:0010895)	3.16523819
22	Abnormality of serine family amino acid metabolism (HP:0010894)	3.16523819
23	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.12860542
24	Methylmalonic aciduria (HP:0012120)	3.10106626
25	Abnormality of vitamin metabolism (HP:0100508)	3.09606999
26	Steatorrhea (HP:0002570)	3.02530704
27	Hypobetalipoproteinemia (HP:0003563)	2.92036753
28	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.87703527
29	Chronic diarrhea (HP:0002028)	2.81227502
30	Abdominal distention (HP:0003270)	2.79076072
31	Hyperphosphaturia (HP:0003109)	2.72277029
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.71258015
33	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.71258015
34	Cutaneous melanoma (HP:0012056)	2.70236410
35	Increased purine levels (HP:0004368)	2.69466132
36	Hyperuricemia (HP:0002149)	2.69466132
37	Abnormal hair laboratory examination (HP:0003328)	2.68237646
38	Hepatic necrosis (HP:0002605)	2.62691959
39	Hyperglycinuria (HP:0003108)	2.52773330
40	Tongue fasciculations (HP:0001308)	2.45671936
41	Pili torti (HP:0003777)	2.44711629
42	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.44402963
43	Acute encephalopathy (HP:0006846)	2.44336826
44	Generalized aminoaciduria (HP:0002909)	2.38114517
45	Hypoglycemic coma (HP:0001325)	2.35725585
46	Megaloblastic anemia (HP:0001889)	2.34836801
47	Congenital ichthyosiform erythroderma (HP:0007431)	2.34477708
48	Abnormality of pyrimidine metabolism (HP:0004353)	2.32182967
49	Abnormality of nucleobase metabolism (HP:0010932)	2.31808251
50	Posterior subcapsular cataract (HP:0007787)	2.31740534
51	Abnormality of purine metabolism (HP:0004352)	2.31636506
52	Abnormal mitochondria in muscle tissue (HP:0008316)	2.31155501
53	Abnormal urine phosphate concentration (HP:0012599)	2.31109570
54	Metabolic acidosis (HP:0001942)	2.31015658
55	Hepatocellular necrosis (HP:0001404)	2.29965725
56	Widely patent fontanelles and sutures (HP:0004492)	2.29136560
57	Cerebral edema (HP:0002181)	2.26848442
58	Abnormality of serum amino acid levels (HP:0003112)	2.25940227
59	Cerebral palsy (HP:0100021)	2.22316792
60	Vascular calcification (HP:0004934)	2.20748357
61	Renal tubular acidosis (HP:0001947)	2.20233089
62	Microretrognathia (HP:0000308)	2.19498785
63	Myopathic facies (HP:0002058)	2.19237743
64	Alkalosis (HP:0001948)	2.18067681
65	Intrahepatic cholestasis (HP:0001406)	2.17963507
66	Hyperphosphatemia (HP:0002905)	2.16315547
67	Petechiae (HP:0000967)	2.15420047
68	Mitochondrial inheritance (HP:0001427)	2.14677938
69	Muscle fibrillation (HP:0010546)	2.14309091
70	Vomiting (HP:0002013)	2.09743087
71	Type I transferrin isoform profile (HP:0003642)	2.09058815
72	Acute necrotizing encephalopathy (HP:0006965)	2.07343071
73	Micronodular cirrhosis (HP:0001413)	2.05170702
74	Nephrolithiasis (HP:0000787)	2.03999725
75	Increased CSF lactate (HP:0002490)	2.02484855
76	Increased muscle lipid content (HP:0009058)	2.02349472
77	Upper limb amyotrophy (HP:0009129)	1.99505853
78	Distal upper limb amyotrophy (HP:0007149)	1.99505853
79	Abnormal trabecular bone morphology (HP:0100671)	1.99360022
80	Gout (HP:0001997)	1.96911704
81	Wide cranial sutures (HP:0010537)	1.96445126
82	Reticulocytopenia (HP:0001896)	1.94403333
83	Prolonged neonatal jaundice (HP:0006579)	1.94366858
84	Lactic acidosis (HP:0003128)	1.93914692
85	Subcapsular cataract (HP:0000523)	1.92388615
86	Patchy hypopigmentation of hair (HP:0011365)	1.92251836
87	Xanthomatosis (HP:0000991)	1.91656724
88	Methylmalonic acidemia (HP:0002912)	1.88565606
89	Renal tubular dysfunction (HP:0000124)	1.88010810
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87707141
91	White forelock (HP:0002211)	1.87665163
92	Hand muscle atrophy (HP:0009130)	1.85472518
93	Abnormality of small intestinal villus morphology (HP:0011472)	1.85363605
94	Villous atrophy (HP:0011473)	1.85363605
95	Brittle hair (HP:0002299)	1.85028329
96	Lipid accumulation in hepatocytes (HP:0006561)	1.84028459
97	Pancreatitis (HP:0001733)	1.83437078
98	Hypolipoproteinemia (HP:0010981)	1.82633182
99	Macrocytic anemia (HP:0001972)	1.80800960
100	Stridor (HP:0010307)	1.80599944

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.90463842
2	MST1R	4.14633058
3	ZAK	3.92997665
4	ACVR1B	3.64150361
5	BUB1	3.60556371
6	LMTK2	3.12950436
7	TLK1	3.12460603
8	VRK2	2.77243978
9	PBK	2.39355247
10	PRKG2	2.34168059
11	VRK1	2.34136603
12	MST4	2.28926167
13	TESK1	2.27237291
14	MAP3K12	2.22674308
15	NEK1	2.19076493
16	TAF1	2.02363221
17	ERN1	2.01908603
18	EPHB2	1.88002205
19	PDK2	1.85842162
20	SMG1	1.85466259
21	RPS6KB2	1.67779197
22	TESK2	1.61642739
23	MYLK	1.51639084
24	PTK6	1.48401755
25	PAK4	1.46515351
26	MET	1.42249062
27	TNIK	1.40930701
28	NME2	1.32301483
29	NME1	1.15644774
30	MAP2K2	1.14774081
31	TTK	1.08072757
32	BLK	1.07128067
33	CDK19	1.06870869
34	DAPK3	1.03234088
35	MAP3K11	1.02834837
36	NUAK1	1.02066874
37	GRK6	1.00986734
38	TRIM28	0.99183328
39	STK4	0.92148515
40	BCKDK	0.91595058
41	MATK	0.89322580
42	AURKB	0.88594282
43	MAP3K8	0.84327536
44	BRAF	0.83386178
45	EIF2AK1	0.79692203
46	STK16	0.75804846
47	PRKCI	0.70470605
48	ABL2	0.69465095
49	OXSR1	0.69290962
50	LIMK1	0.67183803
51	SCYL2	0.66373215
52	GRK1	0.64055015
53	ILK	0.63340897
54	AURKA	0.62763047
55	RPS6KA4	0.61245732
56	DAPK1	0.60867204
57	PLK1	0.59358113
58	TAOK1	0.58797967
59	CAMK2G	0.57978070
60	MAP3K1	0.57161683
61	MAP3K3	0.54163968
62	PTK2	0.52172611
63	TBK1	0.51217336
64	ARAF	0.51196979
65	BMX	0.50411439
66	PLK3	0.50300657
67	STK24	0.50165317
68	STK39	0.49977287
69	WEE1	0.45636581
70	MAP2K1	0.42188356
71	KDR	0.41534486
72	PAK1	0.40974035
73	BMPR1B	0.37425528
74	AKT2	0.36328125
75	STK10	0.35599415
76	MAP3K2	0.34660655
77	TSSK6	0.34623125
78	CAMK2D	0.33977570
79	RPS6KA5	0.33941216
80	PRKCD	0.33200792
81	PIM2	0.32648718
82	PRKCE	0.32504678
83	ERBB2	0.32075271
84	CAMK2B	0.30600176
85	MAPKAPK3	0.30280962
86	BCR	0.28994539
87	CSNK1A1	0.28820265
88	PRKCQ	0.28539948
89	CDK7	0.26911812
90	FGFR4	0.25858751
91	BRSK1	0.25520062
92	PRKCA	0.25307814
93	PRKCZ	0.24776219
94	CSNK2A1	0.24453980
95	SRPK1	0.23571248
96	DYRK2	0.22375151
97	GRK5	0.22040744
98	CSNK2A2	0.20505645
99	FER	0.19197884
100	ROCK1	0.17362876

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.50738815
2	Fat digestion and absorption_Homo sapiens_hsa04975	4.16691484
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.89947954
4	Sulfur metabolism_Homo sapiens_hsa00920	3.31580102
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.89288275
6	Proteasome_Homo sapiens_hsa03050	2.54487969
7	Glutathione metabolism_Homo sapiens_hsa00480	2.41780950
8	Sulfur relay system_Homo sapiens_hsa04122	2.33006022
9	Renin-angiotensin system_Homo sapiens_hsa04614	2.32469740
10	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.30151337
11	Arginine biosynthesis_Homo sapiens_hsa00220	2.14156238
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.88279640
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.87332851
14	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.83914637
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.76449044
16	Pentose phosphate pathway_Homo sapiens_hsa00030	1.69237477
17	Galactose metabolism_Homo sapiens_hsa00052	1.56504912
18	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.55658729
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.52552436
20	Protein digestion and absorption_Homo sapiens_hsa04974	1.48135079
21	Histidine metabolism_Homo sapiens_hsa00340	1.46870441
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.44282438
23	Mineral absorption_Homo sapiens_hsa04978	1.40583882
24	Folate biosynthesis_Homo sapiens_hsa00790	1.37033995
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.34944088
26	Retinol metabolism_Homo sapiens_hsa00830	1.34685080
27	Fatty acid degradation_Homo sapiens_hsa00071	1.34582365
28	Phenylalanine metabolism_Homo sapiens_hsa00360	1.30425399
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.28502761
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.28466192
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27992627
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25879088
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.24868453
34	Ribosome_Homo sapiens_hsa03010	1.24316980
35	Fatty acid elongation_Homo sapiens_hsa00062	1.23175862
36	Parkinsons disease_Homo sapiens_hsa05012	1.22867831
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22728372
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.11546614
39	Carbon metabolism_Homo sapiens_hsa01200	1.11285521
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.11079802
41	Caffeine metabolism_Homo sapiens_hsa00232	1.10619321
42	Vibrio cholerae infection_Homo sapiens_hsa05110	1.08643633
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.08226476
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08215677
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07932078
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04860059
47	Pancreatic secretion_Homo sapiens_hsa04972	1.04636361
48	Base excision repair_Homo sapiens_hsa03410	1.00083176
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98087038
50	Asthma_Homo sapiens_hsa05310	0.97764949
51	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.96879151
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93922612
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93384961
54	Huntingtons disease_Homo sapiens_hsa05016	0.91265519
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.88209533
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.86878817
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84771446
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84173157
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.81273275
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.77573404
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76149327
62	Bile secretion_Homo sapiens_hsa04976	0.74641291
63	Alcoholism_Homo sapiens_hsa05034	0.72298290
64	PPAR signaling pathway_Homo sapiens_hsa03320	0.72073622
65	Metabolic pathways_Homo sapiens_hsa01100	0.67955739
66	Peroxisome_Homo sapiens_hsa04146	0.66235553
67	Alzheimers disease_Homo sapiens_hsa05010	0.66130637
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.62776139
69	Mismatch repair_Homo sapiens_hsa03430	0.56731257
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.56053998
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55357652
72	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54053250
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51529613
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50972544
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50292219
76	Tight junction_Homo sapiens_hsa04530	0.49905902
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49606007
78	DNA replication_Homo sapiens_hsa03030	0.48933792
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48830553
80	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45554031
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.40936997
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39511183
83	Propanoate metabolism_Homo sapiens_hsa00640	0.38793862
84	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.37886263
85	Protein export_Homo sapiens_hsa03060	0.37274303
86	Butanoate metabolism_Homo sapiens_hsa00650	0.36035837
87	Spliceosome_Homo sapiens_hsa03040	0.35709356
88	Thyroid cancer_Homo sapiens_hsa05216	0.26799917
89	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.26601652
90	Purine metabolism_Homo sapiens_hsa00230	0.23537132
91	RNA polymerase_Homo sapiens_hsa03020	0.23316337
92	Other glycan degradation_Homo sapiens_hsa00511	0.22454088
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.19511563
94	Allograft rejection_Homo sapiens_hsa05330	0.18168292
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.16175173
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15456496
97	Viral carcinogenesis_Homo sapiens_hsa05203	0.15320328
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15318864
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.15197965
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.13999029

KRT8P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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