ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	GDP-mannose metabolic process (GO:0019673)	5.16346231
2	NADH metabolic process (GO:0006734)	4.74608053
3	angiotensin maturation (GO:0002003)	4.58205685
4	urea cycle (GO:0000050)	4.26408722
5	antibacterial humoral response (GO:0019731)	4.12509725
6	nitrogen cycle metabolic process (GO:0071941)	4.01910768
7	urea metabolic process (GO:0019627)	3.92691698
8	antimicrobial humoral response (GO:0019730)	3.92020421
9	hepatocyte apoptotic process (GO:0097284)	3.85018826
10	epoxygenase P450 pathway (GO:0019373)	3.66953295
11	positive regulation of pseudopodium assembly (GO:0031274)	3.66092650
12	regulation of guanylate cyclase activity (GO:0031282)	3.63790649
13	N-acetylneuraminate metabolic process (GO:0006054)	3.58036739
14	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.53511525
15	Golgi transport vesicle coating (GO:0048200)	3.51813622
16	COPI coating of Golgi vesicle (GO:0048205)	3.51813622
17	positive regulation of histone deacetylation (GO:0031065)	3.48768577
18	regulation of RNA export from nucleus (GO:0046831)	3.45940345
19	homocysteine metabolic process (GO:0050667)	3.25284446
20	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.23171685
21	regulation of pseudopodium assembly (GO:0031272)	3.09708722
22	protoporphyrinogen IX metabolic process (GO:0046501)	3.03071468
23	ribosomal small subunit biogenesis (GO:0042274)	3.02652920
24	regulation of cellular extravasation (GO:0002691)	3.00033322
25	regulation of bile acid biosynthetic process (GO:0070857)	2.99243316
26	nucleotide-sugar biosynthetic process (GO:0009226)	2.95806074
27	proteasome assembly (GO:0043248)	2.93621440
28	tolerance induction (GO:0002507)	2.91790310
29	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.91217337
30	positive regulation of protein deacetylation (GO:0090312)	2.89567699
31	amino sugar catabolic process (GO:0046348)	2.87722897
32	fructose metabolic process (GO:0006000)	2.86910339
33	base-excision repair, AP site formation (GO:0006285)	2.85949534
34	response to food (GO:0032094)	2.85115126
35	ncRNA 3-end processing (GO:0043628)	2.76948830
36	DNA replication initiation (GO:0006270)	2.73029312
37	regulation of nucleobase-containing compound transport (GO:0032239)	2.70198563
38	mitotic chromosome condensation (GO:0007076)	2.70132016
39	regulation of keratinocyte differentiation (GO:0045616)	2.66074504
40	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.65545722
41	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.65359747
42	positive regulation of guanylate cyclase activity (GO:0031284)	2.61780752
43	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.61623450
44	histone H3-K36 demethylation (GO:0070544)	2.59483771
45	purine deoxyribonucleotide catabolic process (GO:0009155)	2.57597127
46	actin nucleation (GO:0045010)	2.57506101
47	ribosome assembly (GO:0042255)	2.52155785
48	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.51876832
49	cellular response to cadmium ion (GO:0071276)	2.49658781
50	pyrimidine dimer repair (GO:0006290)	2.48816231
51	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.47952931
52	ER overload response (GO:0006983)	2.47695061
53	hemidesmosome assembly (GO:0031581)	2.45219315
54	negative regulation of epidermal cell differentiation (GO:0045605)	2.44544847
55	very-low-density lipoprotein particle assembly (GO:0034379)	2.44162156
56	sphingomyelin metabolic process (GO:0006684)	2.43284882
57	formation of translation preinitiation complex (GO:0001731)	2.38504850
58	defense response to fungus (GO:0050832)	2.38503930
59	regulation of histone H3-K27 methylation (GO:0061085)	2.37634694
60	rRNA methylation (GO:0031167)	2.37445126
61	cytokinetic process (GO:0032506)	2.35910355
62	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.34279477
63	viral mRNA export from host cell nucleus (GO:0046784)	2.33619243
64	UV protection (GO:0009650)	2.31939526
65	nucleoside diphosphate biosynthetic process (GO:0009133)	2.31932677
66	alkaloid metabolic process (GO:0009820)	2.30500850
67	ribosomal small subunit assembly (GO:0000028)	2.30045066
68	mRNA cleavage (GO:0006379)	2.28141445
69	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.28042836
70	intestinal absorption (GO:0050892)	2.26928932
71	positive regulation of glycoprotein metabolic process (GO:1903020)	2.25565466
72	mitotic G1/S transition checkpoint (GO:0044819)	2.25257683
73	DNA strand elongation involved in DNA replication (GO:0006271)	2.24990540
74	regulation of triglyceride catabolic process (GO:0010896)	2.24808242
75	negative regulation of DNA repair (GO:0045738)	2.23525578
76	DNA strand elongation (GO:0022616)	2.22813188
77	regulation of histone deacetylation (GO:0031063)	2.21383828
78	dosage compensation (GO:0007549)	2.18459268
79	monosaccharide catabolic process (GO:0046365)	2.17514397
80	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.17444781
81	ribonucleoprotein complex biogenesis (GO:0022613)	2.17331885
82	low-density lipoprotein particle remodeling (GO:0034374)	2.16847333
83	eosinophil chemotaxis (GO:0048245)	2.16516643
84	trophectodermal cell differentiation (GO:0001829)	2.16335624
85	regulation of cholesterol homeostasis (GO:2000188)	2.15371923
86	macrophage chemotaxis (GO:0048246)	2.14577151
87	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.14557935
88	endocrine process (GO:0050886)	2.14557935
89	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.14557935
90	positive regulation of RNA splicing (GO:0033120)	2.14266864
91	vitamin transport (GO:0051180)	2.13474662
92	diacylglycerol metabolic process (GO:0046339)	2.13169622
93	response to laminar fluid shear stress (GO:0034616)	2.12947715
94	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.11095337
95	nuclear pore complex assembly (GO:0051292)	2.10674873
96	response to UV-C (GO:0010225)	2.10121727
97	centriole replication (GO:0007099)	2.09887905
98	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.09740262
99	positive regulation of epidermal cell differentiation (GO:0045606)	2.09627299
100	ribosome biogenesis (GO:0042254)	2.09315253

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.79972395
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.49882244
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.47393054
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.46652910
5	MYC_22102868_ChIP-Seq_BL_Human	2.42215993
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.16209887
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.15771744
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.12379475
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.11587783
10	DCP1A_22483619_ChIP-Seq_HELA_Human	2.05099146
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02617457
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98013766
13	VDR_21846776_ChIP-Seq_THP-1_Human	1.94387044
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.92492697
15	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.82751667
16	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.81270831
17	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.73039192
18	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.70611152
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.69465455
20	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.66799418
21	XRN2_22483619_ChIP-Seq_HELA_Human	1.65774462
22	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.62318604
23	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.62023106
24	KDM5A_27292631_Chip-Seq_BREAST_Human	1.61187171
25	GATA6_25053715_ChIP-Seq_YYC3_Human	1.61017173
26	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.60636764
27	CIITA_25753668_ChIP-Seq_RAJI_Human	1.59708033
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.59324804
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.56551544
30	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.56432072
31	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.55708966
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.54521220
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53407338
34	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.48427402
35	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.45473128
36	RACK7_27058665_Chip-Seq_MCF-7_Human	1.44127086
37	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.41812754
38	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.39509505
39	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.37337573
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.37275969
41	MAF_26560356_Chip-Seq_TH1_Human	1.35887389
42	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.35176778
43	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.34423790
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33780856
45	MYB_26560356_Chip-Seq_TH1_Human	1.33232321
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.31916446
47	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.31713259
48	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.31688553
49	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.30495217
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.30380603
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28196164
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.26440135
53	ATF3_27146783_Chip-Seq_COLON_Human	1.25586558
54	MAF_26560356_Chip-Seq_TH2_Human	1.25325450
55	ZNF263_19887448_ChIP-Seq_K562_Human	1.25302115
56	BCOR_27268052_Chip-Seq_Bcells_Human	1.24959250
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24865440
58	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.24857622
59	MYB_26560356_Chip-Seq_TH2_Human	1.24252667
60	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.20825013
61	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.20494799
62	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19669022
63	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.19129698
64	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.19025939
65	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18803592
66	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.18037151
67	AR_21909140_ChIP-Seq_LNCAP_Human	1.17180020
68	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.16482995
69	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.15996272
70	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15881915
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15285991
72	P68_20966046_ChIP-Seq_HELA_Human	1.13820294
73	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.12909419
74	UTX_26944678_Chip-Seq_JUKART_Human	1.12608427
75	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.12480195
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12263507
77	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.11579434
78	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.10735803
79	GATA4_25053715_ChIP-Seq_YYC3_Human	1.10373910
80	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.09798845
81	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.08690467
82	LXR_22292898_ChIP-Seq_THP-1_Human	1.08539012
83	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.07803332
84	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.07726250
85	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.07425516
86	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06974696
87	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.05941449
88	TFEB_21752829_ChIP-Seq_HELA_Human	1.05925251
89	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.05770201
90	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.04999264
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04755854
92	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.04201625
93	BCL6_27268052_Chip-Seq_Bcells_Human	1.03346298
94	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.01748900
95	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.01676292
96	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.00679064
97	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00363639
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.99986993
99	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.99721028
100	NCOR1_26117541_ChIP-Seq_K562_Human	0.99499311

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.73960875
2	MP0005083_abnormal_biliary_tract	3.68892681
3	MP0005451_abnormal_body_composition	3.61080899
4	MP0001666_abnormal_nutrient_absorption	2.93264479
5	MP0003763_abnormal_thymus_physiology	2.79643458
6	MP0010352_gastrointestinal_tract_polyps	2.54994424
7	MP0003693_abnormal_embryo_hatching	2.54933291
8	MP0005085_abnormal_gallbladder_physiolo	2.54295882
9	MP0002139_abnormal_hepatobiliary_system	2.47947311
10	MP0010234_abnormal_vibrissa_follicle	2.43162322
11	MP0005365_abnormal_bile_salt	2.40522848
12	MP0001873_stomach_inflammation	2.40248604
13	MP0008057_abnormal_DNA_replication	2.35611480
14	MP0009840_abnormal_foam_cell	2.23374550
15	MP0004264_abnormal_extraembryonic_tissu	2.17271426
16	MP0002796_impaired_skin_barrier	2.12552238
17	MP0000490_abnormal_crypts_of	2.11065644
18	MP0010155_abnormal_intestine_physiology	2.06575889
19	MP0008961_abnormal_basal_metabolism	1.94144842
20	MP0008260_abnormal_autophagy	1.93200827
21	MP0004957_abnormal_blastocyst_morpholog	1.91468369
22	MP0003806_abnormal_nucleotide_metabolis	1.89444708
23	MP0008058_abnormal_DNA_repair	1.80954221
24	MP0005501_abnormal_skin_physiology	1.74874009
25	MP0003866_abnormal_defecation	1.70008361
26	MP0004019_abnormal_vitamin_homeostasis	1.66495843
27	MP0002163_abnormal_gland_morphology	1.66187342
28	MP0003252_abnormal_bile_duct	1.63401862
29	MP0003111_abnormal_nucleus_morphology	1.62389176
30	MP0009333_abnormal_splenocyte_physiolog	1.57233938
31	MP0000537_abnormal_urethra_morphology	1.53850459
32	MP0010094_abnormal_chromosome_stability	1.52671547
33	MP0003077_abnormal_cell_cycle	1.42250932
34	MP0000003_abnormal_adipose_tissue	1.41640038
35	MP0001730_embryonic_growth_arrest	1.39225931
36	MP0005058_abnormal_lysosome_morphology	1.38188247
37	MP0002138_abnormal_hepatobiliary_system	1.36710346
38	MP0003221_abnormal_cardiomyocyte_apopto	1.33637878
39	MP0009643_abnormal_urine_homeostasis	1.33021491
40	MP0005670_abnormal_white_adipose	1.31093836
41	MP0000477_abnormal_intestine_morphology	1.28495939
42	MP0002396_abnormal_hematopoietic_system	1.26808004
43	MP0009379_abnormal_foot_pigmentation	1.26365053
44	MP0003315_abnormal_perineum_morphology	1.25341868
45	MP0008007_abnormal_cellular_replicative	1.24446864
46	MP0006035_abnormal_mitochondrial_morpho	1.14848138
47	MP0003868_abnormal_feces_composition	1.11803107
48	MP0002166_altered_tumor_susceptibility	1.08682095
49	MP0001800_abnormal_humoral_immune	1.08254808
50	MP0010329_abnormal_lipoprotein_level	1.06357185
51	MP0005076_abnormal_cell_differentiation	1.05606417
52	MP0003786_premature_aging	1.05460388
53	MP0001764_abnormal_homeostasis	1.04491381
54	MP0000703_abnormal_thymus_morphology	1.04321974
55	MP0001243_abnormal_dermal_layer	1.03988903
56	MP0002970_abnormal_white_adipose	1.03780045
57	MP0005375_adipose_tissue_phenotype	1.03723497
58	MP0002722_abnormal_immune_system	1.00601865
59	MP0008875_abnormal_xenobiotic_pharmacok	0.96956670
60	MP0002019_abnormal_tumor_incidence	0.96319453
61	MP0000015_abnormal_ear_pigmentation	0.94584085
62	MP0000609_abnormal_liver_physiology	0.94558041
63	MP0003718_maternal_effect	0.94015474
64	MP0001845_abnormal_inflammatory_respons	0.92430323
65	MP0003436_decreased_susceptibility_to	0.91804288
66	MP0005409_darkened_coat_color	0.91585786
67	MP0002136_abnormal_kidney_physiology	0.90611235
68	MP0003959_abnormal_lean_body	0.87867665
69	MP0001819_abnormal_immune_cell	0.87834110
70	MP0002420_abnormal_adaptive_immunity	0.87376748
71	MP0009115_abnormal_fat_cell	0.86821283
72	MP0000689_abnormal_spleen_morphology	0.85066824
73	MP0003566_abnormal_cell_adhesion	0.84557705
74	MP0002398_abnormal_bone_marrow	0.84346701
75	MP0000716_abnormal_immune_system	0.83370282
76	MP0001216_abnormal_epidermal_layer	0.83303907
77	MP0002006_tumorigenesis	0.82862708
78	MP0004782_abnormal_surfactant_physiolog	0.82632810
79	MP0000350_abnormal_cell_proliferation	0.82598654
80	MP0002098_abnormal_vibrissa_morphology	0.82299232
81	MP0000598_abnormal_liver_morphology	0.81845151
82	MP0004947_skin_inflammation	0.81136117
83	MP0000538_abnormal_urinary_bladder	0.80958491
84	MP0005310_abnormal_salivary_gland	0.80814265
85	MP0000462_abnormal_digestive_system	0.80659702
86	MP0005666_abnormal_adipose_tissue	0.79996171
87	MP0005266_abnormal_metabolism	0.79665923
88	MP0002452_abnormal_antigen_presenting	0.79518568
89	MP0002877_abnormal_melanocyte_morpholog	0.79304931
90	MP0005332_abnormal_amino_acid	0.78720867
91	MP0003091_abnormal_cell_migration	0.78214340
92	MP0002429_abnormal_blood_cell	0.78181681
93	MP0005025_abnormal_response_to	0.76402181
94	MP0000313_abnormal_cell_death	0.76378438
95	MP0005334_abnormal_fat_pad	0.76218377
96	MP0009931_abnormal_skin_appearance	0.75620945
97	MP0004185_abnormal_adipocyte_glucose	0.74887713
98	MP0000858_altered_metastatic_potential	0.74348184
99	MP0002080_prenatal_lethality	0.73913199
100	MP0002086_abnormal_extraembryonic_tissu	0.73641171

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.93254491
2	Malnutrition (HP:0004395)	4.08084796
3	Alopecia of scalp (HP:0002293)	3.55299520
4	Microvesicular hepatic steatosis (HP:0001414)	3.44531799
5	Hypobetalipoproteinemia (HP:0003563)	3.09926945
6	Abnormality of pyrimidine metabolism (HP:0004353)	3.01114188
7	Upper limb amyotrophy (HP:0009129)	2.97961601
8	Distal upper limb amyotrophy (HP:0007149)	2.97961601
9	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.92308557
10	Pustule (HP:0200039)	2.85872875
11	Hand muscle atrophy (HP:0009130)	2.80000751
12	Abnormal tarsal ossification (HP:0008369)	2.74283474
13	Micronodular cirrhosis (HP:0001413)	2.73987635
14	Urethral obstruction (HP:0000796)	2.73911793
15	Increased connective tissue (HP:0009025)	2.60813719
16	Increased muscle lipid content (HP:0009058)	2.60772923
17	Flat acetabular roof (HP:0003180)	2.59075011
18	Ureteral stenosis (HP:0000071)	2.58090279
19	Nausea (HP:0002018)	2.53448054
20	Proximal tubulopathy (HP:0000114)	2.52992651
21	Increased intramyocellular lipid droplets (HP:0012240)	2.51138089
22	Chronic diarrhea (HP:0002028)	2.45415207
23	Renal tubular acidosis (HP:0001947)	2.44677413
24	Sparse lateral eyebrow (HP:0005338)	2.40982758
25	Abnormality of the distal phalanges of the toes (HP:0010182)	2.38337856
26	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.34052931
27	Abdominal distention (HP:0003270)	2.33020917
28	Reduced antithrombin III activity (HP:0001976)	2.29111837
29	Abnormal foot bone ossification (HP:0010675)	2.27456640
30	Eczematoid dermatitis (HP:0000976)	2.27123515
31	Difficulty climbing stairs (HP:0003551)	2.23092922
32	Villous atrophy (HP:0011473)	2.22835132
33	Abnormality of small intestinal villus morphology (HP:0011472)	2.22835132
34	Poikiloderma (HP:0001029)	2.21500635
35	Glycosuria (HP:0003076)	2.21177353
36	Abnormality of urine glucose concentration (HP:0011016)	2.21177353
37	Ureteral obstruction (HP:0006000)	2.20418180
38	Microretrognathia (HP:0000308)	2.20106299
39	IgM deficiency (HP:0002850)	2.15614171
40	Abnormal hair laboratory examination (HP:0003328)	2.15607942
41	Anteriorly placed anus (HP:0001545)	2.15145455
42	Subacute progressive viral hepatitis (HP:0006572)	2.14307661
43	Milia (HP:0001056)	2.13047550
44	Abnormal pancreas size (HP:0012094)	2.11669241
45	Alkalosis (HP:0001948)	2.10865567
46	IgA deficiency (HP:0002720)	2.10748489
47	Widely patent fontanelles and sutures (HP:0004492)	2.09361759
48	Hydroxyprolinuria (HP:0003080)	2.09249681
49	Abnormality of proline metabolism (HP:0010907)	2.09249681
50	Entropion (HP:0000621)	2.05757504
51	Abnormality of B cell number (HP:0010975)	2.05235471
52	Wide cranial sutures (HP:0010537)	2.02132706
53	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.01825480
54	Prolonged partial thromboplastin time (HP:0003645)	2.01793726
55	Back pain (HP:0003418)	2.00437543
56	Hyperammonemia (HP:0001987)	1.99746421
57	Thick nail (HP:0001805)	1.97394951
58	Hypoplasia of the thymus (HP:0000778)	1.95101077
59	B lymphocytopenia (HP:0010976)	1.94014868
60	Broad face (HP:0000283)	1.90438510
61	Progressive hearing impairment (HP:0001730)	1.90231234
62	Renal tubular dysfunction (HP:0000124)	1.86566245
63	Squamous cell carcinoma (HP:0002860)	1.86396284
64	Conjugated hyperbilirubinemia (HP:0002908)	1.85223215
65	Rhabdomyolysis (HP:0003201)	1.84479662
66	Recurrent bronchitis (HP:0002837)	1.82350567
67	Abnormality of the preputium (HP:0100587)	1.81880974
68	Birth length less than 3rd percentile (HP:0003561)	1.81801342
69	Neonatal respiratory distress (HP:0002643)	1.81776640
70	Ileus (HP:0002595)	1.80955716
71	Periodontitis (HP:0000704)	1.78277764
72	Fat malabsorption (HP:0002630)	1.77970156
73	Generalized hyperpigmentation (HP:0007440)	1.77729584
74	Hemorrhage of the eye (HP:0011885)	1.77454128
75	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.76905545
76	Dicarboxylic aciduria (HP:0003215)	1.76905545
77	Abnormality of the prostate (HP:0008775)	1.75473124
78	Abnormality of nucleobase metabolism (HP:0010932)	1.74888080
79	Pili torti (HP:0003777)	1.74592338
80	Autoimmune hemolytic anemia (HP:0001890)	1.74427190
81	Abnormality of T cells (HP:0002843)	1.73951381
82	Xanthomatosis (HP:0000991)	1.73841033
83	Right ventricular cardiomyopathy (HP:0011663)	1.73309145
84	Fragile skin (HP:0001030)	1.73267496
85	Hyperphosphaturia (HP:0003109)	1.72992238
86	Abnormal urine phosphate concentration (HP:0012599)	1.72209960
87	T lymphocytopenia (HP:0005403)	1.71786413
88	Long foot (HP:0001833)	1.71352967
89	Cutaneous photosensitivity (HP:0000992)	1.71127809
90	Flattened epiphyses (HP:0003071)	1.69404109
91	Abnormality of vitamin B metabolism (HP:0004340)	1.69357049
92	Hyperuricemia (HP:0002149)	1.69127855
93	Increased purine levels (HP:0004368)	1.69127855
94	Abnormality of T cell number (HP:0011839)	1.68937466
95	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.68851033
96	Metabolic acidosis (HP:0001942)	1.68040838
97	IgG deficiency (HP:0004315)	1.66426866
98	Severe combined immunodeficiency (HP:0004430)	1.65553715
99	External ophthalmoplegia (HP:0000544)	1.65503028
100	Megaloblastic anemia (HP:0001889)	1.65483436

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.38413494
2	SMG1	4.31020892
3	NEK2	4.29560240
4	MST1R	3.15303161
5	CDK12	2.92336742
6	ERN1	2.84909716
7	TESK2	2.67403403
8	CCNB1	2.56921202
9	VRK2	2.35742810
10	RPS6KB2	2.21277491
11	MAP4K1	1.93736546
12	TLK1	1.87588436
13	PDK2	1.72923616
14	EIF2AK3	1.69479757
15	EIF2AK1	1.67676306
16	PASK	1.61670226
17	MST4	1.58899175
18	CAMKK2	1.58544936
19	ACVR1B	1.58254967
20	PBK	1.55442147
21	FGFR4	1.41820323
22	GRK6	1.33082630
23	BUB1	1.32707176
24	ZAK	1.31478098
25	NME2	1.30210803
26	AURKB	1.30057405
27	PAK4	1.29643997
28	SIK3	1.27484270
29	TESK1	1.27396471
30	TRIB3	1.20406134
31	CDK9	1.19991048
32	STK10	1.19506375
33	ICK	1.19080070
34	MAPK11	1.18410326
35	MELK	1.17898227
36	PRPF4B	1.16733616
37	CHUK	1.14793610
38	MAP3K12	1.13723132
39	RPS6KA4	1.11262417
40	CAMK1D	1.09503766
41	LRRK2	1.08911570
42	SIK1	1.05782689
43	TAF1	0.99338409
44	SCYL2	0.95821501
45	MAP3K10	0.91083880
46	TBK1	0.87649789
47	MAP3K8	0.85980544
48	IRAK3	0.83239417
49	CHEK1	0.81766866
50	PRKG2	0.80511652
51	VRK1	0.79783769
52	ZAP70	0.79578473
53	CDK4	0.78129824
54	DAPK1	0.77763461
55	TXK	0.75608989
56	MAP2K2	0.74743868
57	PTK6	0.74227758
58	CAMKK1	0.72401768
59	AURKA	0.69784068
60	STK4	0.69591509
61	CDC7	0.69071200
62	CDK6	0.68046902
63	CDK7	0.66028782
64	MAP3K13	0.64082771
65	MYLK	0.61291655
66	DAPK3	0.58196205
67	RPS6KA5	0.56915370
68	MAP3K14	0.56228165
69	PIM2	0.55834570
70	KSR2	0.53721959
71	MET	0.53452766
72	MTOR	0.53204749
73	MAP3K3	0.51706892
74	ITK	0.51008647
75	BLK	0.50939553
76	WNK4	0.50739734
77	STK39	0.50457325
78	ATR	0.48559970
79	LMTK2	0.48252320
80	PIM1	0.47653885
81	MAP3K2	0.45036649
82	IKBKB	0.44614356
83	MAP3K7	0.43240867
84	IKBKE	0.42374056
85	EPHB1	0.41841807
86	LCK	0.40459828
87	AKT2	0.39312553
88	MAP3K1	0.38814102
89	PLK1	0.34150298
90	CHEK2	0.33587349
91	RIPK1	0.32655136
92	MAPKAPK3	0.32249878
93	CAMK4	0.31797305
94	CLK1	0.31296749
95	CDK8	0.30455403
96	BMPR2	0.30331543
97	CDK2	0.29643706
98	PAK2	0.29418046
99	PRKCI	0.27888352
100	CDK1	0.27071134

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.80130320
2	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.40006860
3	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.27851603
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.88278936
5	DNA replication_Homo sapiens_hsa03030	2.73672307
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.57739645
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.57652269
8	Sulfur relay system_Homo sapiens_hsa04122	2.45351577
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.31371229
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.16682789
11	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.10611994
12	Spliceosome_Homo sapiens_hsa03040	2.08151130
13	Base excision repair_Homo sapiens_hsa03410	1.98261391
14	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.91900888
15	Proteasome_Homo sapiens_hsa03050	1.88076418
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.66716702
17	Pentose phosphate pathway_Homo sapiens_hsa00030	1.65096514
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.63521709
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.52839531
20	Sulfur metabolism_Homo sapiens_hsa00920	1.50925544
21	Viral carcinogenesis_Homo sapiens_hsa05203	1.50708951
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.47650529
23	Glutathione metabolism_Homo sapiens_hsa00480	1.47217036
24	Galactose metabolism_Homo sapiens_hsa00052	1.47123751
25	Thyroid cancer_Homo sapiens_hsa05216	1.43032866
26	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.42479094
27	Mismatch repair_Homo sapiens_hsa03430	1.35321891
28	Caffeine metabolism_Homo sapiens_hsa00232	1.32461968
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.22959704
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18810000
31	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.17639062
32	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.17316323
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.11826669
34	Carbon metabolism_Homo sapiens_hsa01200	1.10456132
35	Alcoholism_Homo sapiens_hsa05034	1.10307464
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.09004974
37	Phenylalanine metabolism_Homo sapiens_hsa00360	1.07447832
38	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.04316047
39	RNA transport_Homo sapiens_hsa03013	1.04268797
40	Folate biosynthesis_Homo sapiens_hsa00790	1.02731247
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.02035702
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.01562187
43	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.00839885
44	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.93602282
45	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.89778187
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87671434
47	Ribosome_Homo sapiens_hsa03010	0.86375508
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86261298
49	Other glycan degradation_Homo sapiens_hsa00511	0.83904911
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82746427
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.81102979
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.81004372
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80522776
54	Cell cycle_Homo sapiens_hsa04110	0.80504317
55	Hepatitis C_Homo sapiens_hsa05160	0.80432506
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78406994
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78139367
58	Herpes simplex infection_Homo sapiens_hsa05168	0.76081781
59	Protein digestion and absorption_Homo sapiens_hsa04974	0.73296653
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71824237
61	p53 signaling pathway_Homo sapiens_hsa04115	0.69666921
62	Retinol metabolism_Homo sapiens_hsa00830	0.67519100
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66030496
64	Pancreatic cancer_Homo sapiens_hsa05212	0.62802737
65	Lysine degradation_Homo sapiens_hsa00310	0.61848449
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.61289101
67	Apoptosis_Homo sapiens_hsa04210	0.59635191
68	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.58096565
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.57608499
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.56532075
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56333951
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52564682
73	Vibrio cholerae infection_Homo sapiens_hsa05110	0.51994410
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.51727170
75	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51454923
76	Bile secretion_Homo sapiens_hsa04976	0.49798612
77	RNA polymerase_Homo sapiens_hsa03020	0.49538028
78	Acute myeloid leukemia_Homo sapiens_hsa05221	0.49155056
79	Mineral absorption_Homo sapiens_hsa04978	0.47974826
80	HTLV-I infection_Homo sapiens_hsa05166	0.47651536
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46893069
82	Homologous recombination_Homo sapiens_hsa03440	0.43099675
83	Bladder cancer_Homo sapiens_hsa05219	0.42156008
84	Histidine metabolism_Homo sapiens_hsa00340	0.40790957
85	Measles_Homo sapiens_hsa05162	0.39824328
86	Hepatitis B_Homo sapiens_hsa05161	0.38044538
87	Pancreatic secretion_Homo sapiens_hsa04972	0.37242847
88	Fatty acid degradation_Homo sapiens_hsa00071	0.37102768
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.37045646
90	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.36795573
91	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34508387
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.33975694
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33959698
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33227228
95	Non-small cell lung cancer_Homo sapiens_hsa05223	0.32143969
96	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.32078106
97	Metabolic pathways_Homo sapiens_hsa01100	0.31765502
98	Influenza A_Homo sapiens_hsa05164	0.31456854
99	Fatty acid elongation_Homo sapiens_hsa00062	0.31275890
100	Peroxisome_Homo sapiens_hsa04146	0.29500451

KRT8P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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