ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.72209960
2	regulation of isotype switching to IgG isotypes (GO:0048302)	6.12623777
3	regulation of regulatory T cell differentiation (GO:0045589)	5.83353622
4	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.73464359
5	negative regulation of B cell apoptotic process (GO:0002903)	5.11915501
6	positive regulation of interleukin-17 production (GO:0032740)	4.88943092
7	ribosome biogenesis (GO:0042254)	4.87456139
8	xenobiotic catabolic process (GO:0042178)	4.77903770
9	DNA unwinding involved in DNA replication (GO:0006268)	4.71131975
10	positive regulation of isotype switching (GO:0045830)	4.55484983
11	regulation of mitochondrial translation (GO:0070129)	4.45280287
12	regulation of immunoglobulin secretion (GO:0051023)	4.32210795
13	proteasome assembly (GO:0043248)	4.28836257
14	pseudouridine synthesis (GO:0001522)	4.17052084
15	regulation of interleukin-17 production (GO:0032660)	4.13540593
16	positive regulation of DNA recombination (GO:0045911)	4.08585855
17	daunorubicin metabolic process (GO:0044597)	4.08110075
18	polyketide metabolic process (GO:0030638)	4.08110075
19	doxorubicin metabolic process (GO:0044598)	4.08110075
20	ribonucleoprotein complex biogenesis (GO:0022613)	4.04439090
21	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.91840330
22	maturation of SSU-rRNA (GO:0030490)	3.87719754
23	signal peptide processing (GO:0006465)	3.84042556
24	cobalamin metabolic process (GO:0009235)	3.79118693
25	ribosomal small subunit assembly (GO:0000028)	3.78784029
26	DNA damage response, detection of DNA damage (GO:0042769)	3.76747285
27	artery smooth muscle contraction (GO:0014824)	3.75303314
28	GMP metabolic process (GO:0046037)	3.69693967
29	ncRNA 3-end processing (GO:0043628)	3.68884282
30	hepatocyte apoptotic process (GO:0097284)	3.67102868
31	aminoglycoside antibiotic metabolic process (GO:0030647)	3.59947736
32	regulation of B cell apoptotic process (GO:0002902)	3.54231774
33	interferon-gamma secretion (GO:0072643)	3.49819973
34	ribosome assembly (GO:0042255)	3.45765944
35	guanosine-containing compound biosynthetic process (GO:1901070)	3.40943620
36	cellular component biogenesis (GO:0044085)	3.36415316
37	ribosomal small subunit biogenesis (GO:0042274)	3.31441840
38	neutrophil mediated immunity (GO:0002446)	3.28161752
39	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.23488306
40	UMP biosynthetic process (GO:0006222)	3.23488306
41	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.23488306
42	UMP metabolic process (GO:0046049)	3.23488306
43	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.18166615
44	nucleoside salvage (GO:0043174)	3.13015124
45	GTP biosynthetic process (GO:0006183)	3.04769669
46	CTP metabolic process (GO:0046036)	3.03594003
47	CTP biosynthetic process (GO:0006241)	3.03594003
48	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.98019274
49	tonic smooth muscle contraction (GO:0014820)	2.97908349
50	protein maturation by protein folding (GO:0022417)	2.97535837
51	mitotic metaphase plate congression (GO:0007080)	2.96901974
52	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.93970751
53	negative regulation of T cell differentiation in thymus (GO:0033085)	2.90743723
54	ribosomal large subunit biogenesis (GO:0042273)	2.90103656
55	rRNA processing (GO:0006364)	2.89116247
56	macrophage chemotaxis (GO:0048246)	2.88823571
57	negative regulation of interleukin-17 production (GO:0032700)	2.81616456
58	inositol phosphate-mediated signaling (GO:0048016)	2.80116980
59	regulation of isotype switching (GO:0045191)	2.79668365
60	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.78887441
61	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.78809207
62	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.78051296
63	positive regulation of B cell mediated immunity (GO:0002714)	2.78051296
64	rRNA metabolic process (GO:0016072)	2.77411626
65	energy homeostasis (GO:0097009)	2.77338306
66	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.73355588
67	natural killer cell activation (GO:0030101)	2.73023529
68	spliceosomal snRNP assembly (GO:0000387)	2.71289259
69	purine nucleotide salvage (GO:0032261)	2.71193420
70	DNA catabolic process, exonucleolytic (GO:0000738)	2.71039817
71	UTP biosynthetic process (GO:0006228)	2.70361824
72	regulation of cellular amino acid metabolic process (GO:0006521)	2.68267752
73	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.67672838
74	inositol phosphate dephosphorylation (GO:0046855)	2.67672838
75	morphogenesis of an endothelium (GO:0003159)	2.66723447
76	endothelial tube morphogenesis (GO:0061154)	2.66723447
77	natural killer cell differentiation (GO:0001779)	2.65496791
78	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.64394715
79	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.63577619
80	transcription from mitochondrial promoter (GO:0006390)	2.63093106
81	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.62948118
82	response to host immune response (GO:0052572)	2.62948118
83	regulation of B cell receptor signaling pathway (GO:0050855)	2.62221139
84	positive regulation of activated T cell proliferation (GO:0042104)	2.61193881
85	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.60415225
86	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.60171494
87	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.60171494
88	quinone metabolic process (GO:1901661)	2.59977013
89	viral transcription (GO:0019083)	2.59705658
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.59100009
91	IMP biosynthetic process (GO:0006188)	2.57299157
92	myeloid leukocyte mediated immunity (GO:0002444)	2.56749041
93	regulation of interferon-beta biosynthetic process (GO:0045357)	2.56438107
94	translation (GO:0006412)	2.56235807
95	cellular response to dsRNA (GO:0071359)	2.55351106
96	positive regulation of immunoglobulin production (GO:0002639)	2.54194167
97	metaphase plate congression (GO:0051310)	2.52937889
98	prostanoid biosynthetic process (GO:0046457)	2.52278825
99	prostaglandin biosynthetic process (GO:0001516)	2.52278825
100	glycoside metabolic process (GO:0016137)	2.52201742

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.74504270
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.17335204
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10399247
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47645978
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.33482594
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.28725816
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.07825907
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.03025061
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.96149936
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.94316518
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.75334171
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.72585445
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72299574
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.62475315
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.61075224
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.39084178
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.37194657
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.36101428
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.32516570
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.30678115
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26985212
22	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.10781662
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.08806025
24	FOXP3_21729870_ChIP-Seq_TREG_Human	2.06894633
25	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.04338805
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.02579408
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.00960503
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99056371
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.96410572
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.91985321
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84940030
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.82180059
33	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.78926990
34	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.77348534
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.73066383
36	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.65538105
37	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.61954964
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.60177920
39	XRN2_22483619_ChIP-Seq_HELA_Human	1.59796304
40	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.59186372
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.58689291
42	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.54986800
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.52715733
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45559940
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44158921
46	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.39824654
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.38667535
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38096138
49	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.36879731
50	MYB_26560356_Chip-Seq_TH2_Human	1.35191251
51	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.33863713
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.32619880
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30411320
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.29920312
55	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.28729337
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.26711103
57	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.26649810
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26324233
59	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.25517310
60	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24529627
61	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.22692949
62	TFEB_21752829_ChIP-Seq_HELA_Human	1.20859475
63	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18930483
64	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.18097232
65	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17694052
66	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.17685440
67	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.17251520
68	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17034802
69	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.16874391
70	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.16356277
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11863561
72	GATA3_26560356_Chip-Seq_TH2_Human	1.10703329
73	SPI1_23547873_ChIP-Seq_NB4_Human	1.10054416
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09196974
75	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.07466924
76	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04324649
77	ZNF263_19887448_ChIP-Seq_K562_Human	1.04029495
78	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.03371444
79	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02420318
80	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01611040
81	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.99458873
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97450798
83	MYB_26560356_Chip-Seq_TH1_Human	0.96122911
84	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.94002357
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92617714
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91403341
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89869893
88	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.88069698
89	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87918828
90	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.87652158
91	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.87652158
92	BCOR_27268052_Chip-Seq_Bcells_Human	0.87214476
93	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.86932311
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.86139492
95	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.85463137
96	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.83972263
97	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83083984
98	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.83022786
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.80920388
100	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.78963428

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001853_heart_inflammation	4.59566632
2	MP0001835_abnormal_antigen_presentation	3.71555567
3	MP0003300_gastrointestinal_ulcer	3.28619449
4	MP0003763_abnormal_thymus_physiology	3.26478570
5	MP0000465_gastrointestinal_hemorrhage	3.00778565
6	MP0008260_abnormal_autophagy	2.95696654
7	MP0005083_abnormal_biliary_tract	2.52591399
8	MP0001666_abnormal_nutrient_absorption	2.40319359
9	MP0003786_premature_aging	2.35449877
10	MP0003693_abnormal_embryo_hatching	2.28810257
11	MP0000604_amyloidosis	2.14316162
12	MP0005671_abnormal_response_to	2.01092343
13	MP0003186_abnormal_redox_activity	1.94993872
14	MP0005257_abnormal_intraocular_pressure	1.92305612
15	MP0001800_abnormal_humoral_immune	1.92249350
16	MP0005451_abnormal_body_composition	1.88293537
17	MP0002148_abnormal_hypersensitivity_rea	1.87547442
18	MP0000516_abnormal_urinary_system	1.83729921
19	MP0005367_renal/urinary_system_phenotyp	1.83729921
20	MP0002139_abnormal_hepatobiliary_system	1.76804314
21	MP0010094_abnormal_chromosome_stability	1.75230416
22	MP0000685_abnormal_immune_system	1.74812957
23	MP0009333_abnormal_splenocyte_physiolog	1.70819858
24	MP0005084_abnormal_gallbladder_morpholo	1.67109551
25	MP0002723_abnormal_immune_serum	1.61188154
26	MP0002452_abnormal_antigen_presenting	1.56392371
27	MP0008875_abnormal_xenobiotic_pharmacok	1.53898865
28	MP0002420_abnormal_adaptive_immunity	1.53094114
29	MP0001790_abnormal_immune_system	1.51435660
30	MP0005387_immune_system_phenotype	1.51435660
31	MP0001819_abnormal_immune_cell	1.48883201
32	MP0002405_respiratory_system_inflammati	1.48327042
33	MP0010234_abnormal_vibrissa_follicle	1.47717980
34	MP0005000_abnormal_immune_tolerance	1.45536069
35	MP0002693_abnormal_pancreas_physiology	1.42461334
36	MP0006292_abnormal_olfactory_placode	1.41971525
37	MP0001845_abnormal_inflammatory_respons	1.40992085
38	MP0008057_abnormal_DNA_replication	1.40856131
39	MP0005365_abnormal_bile_salt	1.39285603
40	MP0009785_altered_susceptibility_to	1.36786452
41	MP0000689_abnormal_spleen_morphology	1.35403654
42	MP0003806_abnormal_nucleotide_metabolis	1.35187824
43	MP0002166_altered_tumor_susceptibility	1.33833758
44	MP0003868_abnormal_feces_composition	1.33401024
45	MP0002722_abnormal_immune_system	1.32206450
46	MP0005058_abnormal_lysosome_morphology	1.31578658
47	MP0002398_abnormal_bone_marrow	1.29745272
48	MP0005025_abnormal_response_to	1.29525241
49	MP0000716_abnormal_immune_system	1.25584140
50	MP0001764_abnormal_homeostasis	1.24143381
51	MP0004957_abnormal_blastocyst_morpholog	1.23559097
52	MP0004264_abnormal_extraembryonic_tissu	1.19429066
53	MP0005501_abnormal_skin_physiology	1.18786500
54	MP0004381_abnormal_hair_follicle	1.14909723
55	MP0008469_abnormal_protein_level	1.14681841
56	MP0002429_abnormal_blood_cell	1.13256990
57	MP0002837_dystrophic_cardiac_calcinosis	1.12668682
58	MP0002019_abnormal_tumor_incidence	1.10917522
59	MP0009697_abnormal_copulation	1.10218997
60	MP0003866_abnormal_defecation	1.09965877
61	MP0002006_tumorigenesis	1.09477526
62	MP0001919_abnormal_reproductive_system	1.08103777
63	MP0000703_abnormal_thymus_morphology	1.05519712
64	MP0008058_abnormal_DNA_repair	1.01778867
65	MP0005332_abnormal_amino_acid	0.96078986
66	MP0000858_altered_metastatic_potential	0.95205456
67	MP0001756_abnormal_urination	0.93621304
68	MP0003172_abnormal_lysosome_physiology	0.93181406
69	MP0010386_abnormal_urinary_bladder	0.92303034
70	MP0005330_cardiomyopathy	0.92255834
71	MP0003453_abnormal_keratinocyte_physiol	0.91731615
72	MP0003195_calcinosis	0.91156545
73	MP0002419_abnormal_innate_immunity	0.90938693
74	MP0005670_abnormal_white_adipose	0.89995935
75	MP0000490_abnormal_crypts_of	0.89441641
76	MP0001730_embryonic_growth_arrest	0.88344077
77	MP0000249_abnormal_blood_vessel	0.87798531
78	MP0009764_decreased_sensitivity_to	0.87634810
79	MP0003436_decreased_susceptibility_to	0.87083765
80	MP0002138_abnormal_hepatobiliary_system	0.86988674
81	MP0000609_abnormal_liver_physiology	0.86905044
82	MP0006054_spinal_hemorrhage	0.86300746
83	MP0005464_abnormal_platelet_physiology	0.86284861
84	MP0005319_abnormal_enzyme/_coenzyme	0.85568168
85	MP0010155_abnormal_intestine_physiology	0.84345617
86	MP0002796_impaired_skin_barrier	0.81287991
87	MP0008873_increased_physiological_sensi	0.80758502
88	MP0003656_abnormal_erythrocyte_physiolo	0.80173687
89	MP0008872_abnormal_physiological_respon	0.79992323
90	MP0005389_reproductive_system_phenotype	0.78772390
91	MP0000313_abnormal_cell_death	0.78710156
92	MP0005075_abnormal_melanosome_morpholog	0.78193632
93	MP0002177_abnormal_outer_ear	0.78106276
94	MP0006036_abnormal_mitochondrial_physio	0.77883063
95	MP0003315_abnormal_perineum_morphology	0.77457520
96	MP0005360_urolithiasis	0.76659271
97	MP0002136_abnormal_kidney_physiology	0.76480518
98	MP0006035_abnormal_mitochondrial_morpho	0.75380320
99	MP0003123_paternal_imprinting	0.74427449
100	MP0000647_abnormal_sebaceous_gland	0.73584470

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.73855463
2	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.73855463
3	Microretrognathia (HP:0000308)	3.70132617
4	Testicular atrophy (HP:0000029)	3.59550049
5	T lymphocytopenia (HP:0005403)	3.30953278
6	Steatorrhea (HP:0002570)	3.21274656
7	Glucose intolerance (HP:0000833)	3.20825844
8	Acute necrotizing encephalopathy (HP:0006965)	3.20264009
9	Microvesicular hepatic steatosis (HP:0001414)	3.15662881
10	Patent foramen ovale (HP:0001655)	3.15637109
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.09591340
12	Increased CSF lactate (HP:0002490)	3.01974265
13	Degeneration of anterior horn cells (HP:0002398)	2.99256808
14	Abnormality of the anterior horn cell (HP:0006802)	2.99256808
15	Amyloidosis (HP:0011034)	2.98427756
16	Abnormality of T cell number (HP:0011839)	2.94463532
17	Stomatitis (HP:0010280)	2.90031466
18	Progressive macrocephaly (HP:0004481)	2.88160067
19	Mitochondrial inheritance (HP:0001427)	2.87753378
20	Abnormality of small intestinal villus morphology (HP:0011472)	2.86070103
21	Villous atrophy (HP:0011473)	2.86070103
22	Elevated erythrocyte sedimentation rate (HP:0003565)	2.82534001
23	Opisthotonus (HP:0002179)	2.79492733
24	Conjunctival hamartoma (HP:0100780)	2.79202581
25	Type I transferrin isoform profile (HP:0003642)	2.78876840
26	Abnormality of alanine metabolism (HP:0010916)	2.73631511
27	Hyperalaninemia (HP:0003348)	2.73631511
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73631511
29	Hepatic necrosis (HP:0002605)	2.72345750
30	Acute encephalopathy (HP:0006846)	2.64907617
31	IgG deficiency (HP:0004315)	2.64092315
32	Hepatocellular necrosis (HP:0001404)	2.63060195
33	Progressive muscle weakness (HP:0003323)	2.57666157
34	Increased serum lactate (HP:0002151)	2.55678869
35	Medulloblastoma (HP:0002885)	2.52544234
36	IgA deficiency (HP:0002720)	2.50034169
37	Abnormality of methionine metabolism (HP:0010901)	2.47381575
38	Neuroendocrine neoplasm (HP:0100634)	2.45156566
39	Gastrointestinal stroma tumor (HP:0100723)	2.44931879
40	Poor speech (HP:0002465)	2.43837021
41	Fat malabsorption (HP:0002630)	2.41594624
42	Neoplasm of the peripheral nervous system (HP:0100007)	2.36956057
43	Megaloblastic anemia (HP:0001889)	2.36061343
44	Acute hepatic failure (HP:0006554)	2.32964729
45	Cerebral edema (HP:0002181)	2.32414927
46	Gout (HP:0001997)	2.32242497
47	Increased serum pyruvate (HP:0003542)	2.31463337
48	Lipid accumulation in hepatocytes (HP:0006561)	2.30714807
49	Cleft eyelid (HP:0000625)	2.29695463
50	J-shaped sella turcica (HP:0002680)	2.27736151
51	Increased intramyocellular lipid droplets (HP:0012240)	2.27267124
52	Macrocytic anemia (HP:0001972)	2.25957764
53	Abnormality of T cells (HP:0002843)	2.24227499
54	Respiratory difficulties (HP:0002880)	2.24196897
55	Increased hepatocellular lipid droplets (HP:0006565)	2.22938541
56	Dicarboxylic aciduria (HP:0003215)	2.21680829
57	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.21680829
58	Colitis (HP:0002583)	2.21200342
59	Methylmalonic acidemia (HP:0002912)	2.19946808
60	Methylmalonic aciduria (HP:0012120)	2.19517991
61	Abnormal glucose tolerance (HP:0001952)	2.19230664
62	Vacuolated lymphocytes (HP:0001922)	2.18911223
63	Respiratory failure (HP:0002878)	2.17624867
64	Cellular immunodeficiency (HP:0005374)	2.16839855
65	Palpitations (HP:0001962)	2.16629725
66	Reduced antithrombin III activity (HP:0001976)	2.14780790
67	Vascular calcification (HP:0004934)	2.13009633
68	Increased muscle lipid content (HP:0009058)	2.11912028
69	Pancytopenia (HP:0001876)	2.11634430
70	3-Methylglutaconic aciduria (HP:0003535)	2.10398127
71	IgM deficiency (HP:0002850)	2.08501369
72	Tinnitus (HP:0000360)	2.07879262
73	Progressive microcephaly (HP:0000253)	2.06244814
74	Abnormal protein N-linked glycosylation (HP:0012347)	2.05365400
75	Abnormal protein glycosylation (HP:0012346)	2.05365400
76	Abnormal glycosylation (HP:0012345)	2.05365400
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.05365400
78	Sparse eyelashes (HP:0000653)	2.03616364
79	Fatigue (HP:0012378)	2.01096060
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00283712
81	Papillary thyroid carcinoma (HP:0002895)	1.99965168
82	Lactic acidosis (HP:0003128)	1.98525270
83	Basal cell carcinoma (HP:0002671)	1.97415070
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97125716
85	Double outlet right ventricle (HP:0001719)	1.96281240
86	Congenital malformation of the right heart (HP:0011723)	1.96281240
87	Pheochromocytoma (HP:0002666)	1.93649090
88	Hypoproteinemia (HP:0003075)	1.91022989
89	Tongue fasciculations (HP:0001308)	1.90939744
90	Lymphopenia (HP:0001888)	1.90886609
91	Abnormality of glycolysis (HP:0004366)	1.90809432
92	Panhypogammaglobulinemia (HP:0003139)	1.89460338
93	Renal cortical cysts (HP:0000803)	1.88974748
94	Generalized aminoaciduria (HP:0002909)	1.87085331
95	Exertional dyspnea (HP:0002875)	1.86509475
96	Agammaglobulinemia (HP:0004432)	1.84179261
97	Exercise intolerance (HP:0003546)	1.83649383
98	Micronodular cirrhosis (HP:0001413)	1.82982667
99	Abnormality of vitamin B metabolism (HP:0004340)	1.82389566
100	Reduced subcutaneous adipose tissue (HP:0003758)	1.81142928

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	6.15424467
2	TESK2	4.30891304
3	NME2	4.15805991
4	TLK1	3.58211523
5	BUB1	2.90358129
6	EPHA2	2.58359275
7	FRK	2.50628900
8	SCYL2	2.41659942
9	IRAK3	2.30682126
10	TESK1	2.25420396
11	BLK	2.23488081
12	MST4	2.05467737
13	EIF2AK1	1.98605467
14	MAPKAPK3	1.86925432
15	IKBKE	1.83789464
16	ACVR1B	1.72567767
17	VRK2	1.71799034
18	TBK1	1.66812105
19	EIF2AK3	1.64968857
20	TEC	1.63306794
21	MELK	1.60156204
22	BMPR1B	1.53163745
23	NEK1	1.47968632
24	CSK	1.44673437
25	STK10	1.35267310
26	CSNK1A1L	1.32028602
27	LIMK1	1.28022240
28	CAMKK2	1.27654803
29	CSNK1G3	1.25255984
30	STK4	1.20029761
31	IKBKB	1.14046940
32	NEK6	1.10927389
33	SRPK1	1.09553994
34	MAP2K7	1.09097584
35	RPS6KB2	1.06623223
36	PAK4	1.05227856
37	PASK	1.04635673
38	PIM2	1.03467660
39	TAOK2	1.02933670
40	MAPK11	1.02686281
41	ITK	0.97098497
42	MAP3K3	0.96612884
43	ZAK	0.95274407
44	RPS6KA5	0.93810050
45	VRK1	0.92468764
46	TXK	0.85357262
47	MAP2K3	0.83580162
48	DAPK1	0.80318553
49	CSNK1G1	0.78664150
50	ICK	0.74896741
51	ERN1	0.72655293
52	GRK6	0.71909649
53	BTK	0.70139335
54	MAP3K5	0.69297491
55	ADRBK2	0.67956378
56	CCNB1	0.67567079
57	AURKB	0.66190997
58	CSNK1G2	0.64135183
59	JAK1	0.63657200
60	PLK1	0.62682789
61	GRK1	0.60564082
62	PIM1	0.56849034
63	PRKCQ	0.55305766
64	EGFR	0.54858626
65	GRK5	0.54755950
66	RPS6KA4	0.53239417
67	TAOK3	0.51431687
68	MAP4K1	0.50525375
69	PIK3CA	0.50456643
70	CHUK	0.47118711
71	MAP3K14	0.47071872
72	PIK3CG	0.46646021
73	LMTK2	0.45843803
74	NME1	0.44640665
75	CSF1R	0.43822947
76	CHEK1	0.43428035
77	CSNK2A2	0.43214179
78	MAP3K8	0.42817050
79	PBK	0.42725437
80	TNIK	0.41845846
81	MAP3K1	0.40705528
82	MAP2K6	0.40433683
83	SMG1	0.39928092
84	ATR	0.36350685
85	CSNK2A1	0.35419277
86	SYK	0.34957094
87	LYN	0.34550945
88	GRK7	0.33954939
89	LRRK2	0.33716061
90	NUAK1	0.33594709
91	LCK	0.32304611
92	AKT2	0.32031665
93	ABL2	0.31484395
94	EIF2AK2	0.30736254
95	RIPK4	0.30450261
96	BCKDK	0.30395389
97	AURKA	0.30160798
98	PTK2B	0.29725772
99	FGFR3	0.28012507
100	ABL1	0.27622523

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.09855822
2	Ribosome_Homo sapiens_hsa03010	3.78202987
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.97005412
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19821827
5	Homologous recombination_Homo sapiens_hsa03440	2.19332956
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.14199073
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.13065518
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.13040529
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10245438
10	Allograft rejection_Homo sapiens_hsa05330	2.02045375
11	Sulfur relay system_Homo sapiens_hsa04122	1.99968660
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.89277643
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.87142173
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.71593873
15	One carbon pool by folate_Homo sapiens_hsa00670	1.68938041
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.67130840
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.64068703
18	Spliceosome_Homo sapiens_hsa03040	1.62562584
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.61748055
20	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.60182685
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58318176
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.57821905
23	Folate biosynthesis_Homo sapiens_hsa00790	1.57527165
24	Other glycan degradation_Homo sapiens_hsa00511	1.55363524
25	DNA replication_Homo sapiens_hsa03030	1.54060340
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.53365693
27	RNA polymerase_Homo sapiens_hsa03020	1.51214574
28	Mismatch repair_Homo sapiens_hsa03430	1.50937620
29	Parkinsons disease_Homo sapiens_hsa05012	1.49280765
30	Asthma_Homo sapiens_hsa05310	1.46010902
31	Pancreatic secretion_Homo sapiens_hsa04972	1.37821557
32	Protein export_Homo sapiens_hsa03060	1.31322274
33	Glutathione metabolism_Homo sapiens_hsa00480	1.25198298
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.22733564
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20889290
36	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.19185497
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.17150436
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.16888848
39	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.15114536
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12937930
41	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.12866099
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.11552940
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03552252
44	Alzheimers disease_Homo sapiens_hsa05010	1.02497934
45	Alcoholism_Homo sapiens_hsa05034	1.01471118
46	RNA transport_Homo sapiens_hsa03013	0.99712143
47	Huntingtons disease_Homo sapiens_hsa05016	0.99387163
48	Basal transcription factors_Homo sapiens_hsa03022	0.99352114
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97618665
50	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.96854237
51	Peroxisome_Homo sapiens_hsa04146	0.96656997
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.96345165
53	Sulfur metabolism_Homo sapiens_hsa00920	0.94930586
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89573069
55	Measles_Homo sapiens_hsa05162	0.89296514
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83117283
57	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.82005535
58	Protein digestion and absorption_Homo sapiens_hsa04974	0.80793093
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80612482
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.80044805
61	Apoptosis_Homo sapiens_hsa04210	0.79691843
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79391417
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.77961462
64	Viral carcinogenesis_Homo sapiens_hsa05203	0.75933407
65	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74360902
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73320902
67	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.71397407
68	Base excision repair_Homo sapiens_hsa03410	0.70807482
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70008344
70	Rheumatoid arthritis_Homo sapiens_hsa05323	0.69857480
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68294858
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.66279463
73	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.64749073
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.64465869
75	Renin-angiotensin system_Homo sapiens_hsa04614	0.62544951
76	Fatty acid elongation_Homo sapiens_hsa00062	0.61097496
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.61020668
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60038851
79	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.59492869
80	Purine metabolism_Homo sapiens_hsa00230	0.57273285
81	Metabolic pathways_Homo sapiens_hsa01100	0.55541081
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55349633
83	Vibrio cholerae infection_Homo sapiens_hsa05110	0.55122653
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54618078
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52071540
86	Galactose metabolism_Homo sapiens_hsa00052	0.52000078
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.51248195
88	Carbon metabolism_Homo sapiens_hsa01200	0.51194952
89	RNA degradation_Homo sapiens_hsa03018	0.50719560
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.50518996
91	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.49118082
92	Legionellosis_Homo sapiens_hsa05134	0.47633795
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47517033
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46248953
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45962386
96	TNF signaling pathway_Homo sapiens_hsa04668	0.45716425
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42501239
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42371140
99	Herpes simplex infection_Homo sapiens_hsa05168	0.40863230
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.38486829

KRT8P34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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