ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	9.98137523
2	cysteine metabolic process (GO:0006534)	9.43368571
3	peptide catabolic process (GO:0043171)	8.18353132
4	icosanoid metabolic process (GO:0006690)	7.20302418
5	fatty acid derivative metabolic process (GO:1901568)	7.20302418
6	mitochondrial calcium ion transport (GO:0006851)	7.19193151
7	unsaturated fatty acid metabolic process (GO:0033559)	6.39617320
8	mitochondrion distribution (GO:0048311)	6.04277776
9	glutathione biosynthetic process (GO:0006750)	5.60108715
10	serine family amino acid biosynthetic process (GO:0009070)	5.32463691
11	peptide metabolic process (GO:0006518)	5.26871979
12	nonribosomal peptide biosynthetic process (GO:0019184)	5.22763793
13	detection of molecule of bacterial origin (GO:0032490)	4.89564822
14	fatty acid biosynthetic process (GO:0006633)	4.83563150
15	artery smooth muscle contraction (GO:0014824)	4.78429276
16	regulation of guanylate cyclase activity (GO:0031282)	4.42009962
17	glutathione derivative biosynthetic process (GO:1901687)	4.20856639
18	glutathione derivative metabolic process (GO:1901685)	4.20856639
19	hepatocyte apoptotic process (GO:0097284)	4.11979377
20	polyketide metabolic process (GO:0030638)	4.01936971
21	doxorubicin metabolic process (GO:0044598)	4.01936971
22	daunorubicin metabolic process (GO:0044597)	4.01936971
23	tonic smooth muscle contraction (GO:0014820)	3.99097048
24	cell communication involved in cardiac conduction (GO:0086065)	3.87360257
25	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.84973010
26	modulation by symbiont of host immune response (GO:0052553)	3.84973010
27	positive regulation by symbiont of host defense response (GO:0052509)	3.84973010
28	modulation by symbiont of host defense response (GO:0052031)	3.84973010
29	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.84973010
30	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.84973010
31	positive regulation of guanylate cyclase activity (GO:0031284)	3.83843910
32	macrophage activation (GO:0042116)	3.83825374
33	cellular modified amino acid catabolic process (GO:0042219)	3.80776846
34	energy homeostasis (GO:0097009)	3.76932104
35	phasic smooth muscle contraction (GO:0014821)	3.75559119
36	cellular amide metabolic process (GO:0043603)	3.72017620
37	regulation of triglyceride catabolic process (GO:0010896)	3.64224125
38	peptide biosynthetic process (GO:0043043)	3.60293596
39	androgen biosynthetic process (GO:0006702)	3.55262749
40	aminoglycoside antibiotic metabolic process (GO:0030647)	3.53551910
41	inositol phosphate-mediated signaling (GO:0048016)	3.52645365
42	prostanoid biosynthetic process (GO:0046457)	3.52080116
43	prostaglandin biosynthetic process (GO:0001516)	3.52080116
44	prostaglandin metabolic process (GO:0006693)	3.51465295
45	prostanoid metabolic process (GO:0006692)	3.51465295
46	neuronal action potential (GO:0019228)	3.50452086
47	glutamate metabolic process (GO:0006536)	3.50002012
48	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.49101069
49	microglial cell activation (GO:0001774)	3.42180111
50	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.41052061
51	primary alcohol catabolic process (GO:0034310)	3.33535027
52	protein ADP-ribosylation (GO:0006471)	3.32393975
53	ketone biosynthetic process (GO:0042181)	3.11367818
54	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.10077482
55	NADH metabolic process (GO:0006734)	3.09162604
56	vitamin transmembrane transport (GO:0035461)	3.08894299
57	digestion (GO:0007586)	3.06074200
58	monocarboxylic acid biosynthetic process (GO:0072330)	3.03371724
59	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.00159092
60	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.00159092
61	endocrine process (GO:0050886)	3.00159092
62	leukotriene biosynthetic process (GO:0019370)	20.0647412
63	interferon-gamma secretion (GO:0072643)	2.97634723
64	urate metabolic process (GO:0046415)	2.93610981
65	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.90059139
66	positive regulation of pseudopodium assembly (GO:0031274)	2.88119617
67	flavonoid metabolic process (GO:0009812)	2.86106720
68	regulation of oxidative phosphorylation (GO:0002082)	2.84548964
69	epoxygenase P450 pathway (GO:0019373)	2.84356114
70	cellular modified amino acid metabolic process (GO:0006575)	2.81986690
71	intestinal absorption (GO:0050892)	2.81252810
72	sulfur amino acid biosynthetic process (GO:0000097)	2.80767265
73	serine family amino acid metabolic process (GO:0009069)	2.76527103
74	arachidonic acid metabolic process (GO:0019369)	2.76458597
75	regulation of cellular respiration (GO:0043457)	2.75129170
76	macroautophagy (GO:0016236)	2.74576582
77	sulfation (GO:0051923)	2.74520769
78	negative regulation of epidermal cell differentiation (GO:0045605)	2.74275914
79	GDP-mannose metabolic process (GO:0019673)	2.73463697
80	cobalamin metabolic process (GO:0009235)	2.72185997
81	glycerol metabolic process (GO:0006071)	2.71632554
82	amide biosynthetic process (GO:0043604)	2.68797541
83	vascular smooth muscle contraction (GO:0014829)	2.67390418
84	macrophage chemotaxis (GO:0048246)	2.62675052
85	cyclooxygenase pathway (GO:0019371)	2.59989006
86	angiotensin maturation (GO:0002003)	2.57949954
87	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.56081254
88	response to food (GO:0032094)	2.55975372
89	glycoside metabolic process (GO:0016137)	2.55470908
90	fatty acid metabolic process (GO:0006631)	2.52727955
91	regulation of tumor necrosis factor biosynthetic process (GO:0042534)	2.52597649
92	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	2.52367996
93	intestinal epithelial cell development (GO:0060576)	2.51850629
94	regulation of pseudopodium assembly (GO:0031272)	2.50351646
95	leukotriene metabolic process (GO:0006691)	14.3496333
96	icosanoid biosynthetic process (GO:0046456)	12.2630120
97	fatty acid derivative biosynthetic process (GO:1901570)	12.2630120
98	bundle of His cell to Purkinje myocyte communication (GO:0086069)	11.7262699
99	glutathione metabolic process (GO:0006749)	10.5816535
100	unsaturated fatty acid biosynthetic process (GO:0006636)	10.2767827

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.12646500
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.13610726
3	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.08913739
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.03591416
5	GATA4_25053715_ChIP-Seq_YYC3_Human	2.97817000
6	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.94170570
7	GATA6_25053715_ChIP-Seq_YYC3_Human	2.90414726
8	VDR_22108803_ChIP-Seq_LS180_Human	2.88649146
9	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.87205975
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.58624823
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.55828969
12	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.49638454
13	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.44746590
14	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.30053976
15	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.27592891
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.26464030
17	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.26063494
18	TCF4_18268006_ChIP-ChIP_LS174T_Human	2.05095961
19	ZNF263_19887448_ChIP-Seq_K562_Human	1.91287478
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.91259735
21	CDX2_22108803_ChIP-Seq_LS180_Human	1.89412427
22	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.83147720
23	SOX2_20726797_ChIP-Seq_SW620_Human	1.72521258
24	KLF5_25053715_ChIP-Seq_YYC3_Human	1.70748999
25	STAT1_20625510_ChIP-Seq_HELA_Human	1.70567567
26	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.66825787
27	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.62738310
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59715156
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.59197103
30	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.49038098
31	OCT4_20526341_ChIP-Seq_ESCs_Human	1.47137975
32	HOXB7_26014856_ChIP-Seq_BT474_Human	1.45992498
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43733070
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.43733070
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.40222074
36	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.39087725
37	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.38985313
38	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.38506228
39	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.33897258
40	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.32856727
41	AR_20517297_ChIP-Seq_VCAP_Human	1.32299226
42	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.31131832
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29225150
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.28516452
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27575054
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27537825
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27119207
48	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.25970635
49	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.23761215
50	ERG_20517297_ChIP-Seq_VCAP_Human	1.21789842
51	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.21064401
52	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19447596
53	ELF5_23300383_ChIP-Seq_T47D_Human	1.17783300
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.14070244
55	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.13784465
56	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10800892
57	NCOR_22424771_ChIP-Seq_293T_Human	1.09876810
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09758048
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.09460801
60	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.09179324
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.07185018
62	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.06897087
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.06596805
64	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06577793
65	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05799855
66	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.04957482
67	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.04032143
68	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.02609602
69	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.01953844
70	AR_21909140_ChIP-Seq_LNCAP_Human	1.01127979
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00944364
72	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00585293
73	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.99236239
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98480036
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.98377580
76	P300_19829295_ChIP-Seq_ESCs_Human	0.98105013
77	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.98087619
78	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.95667099
79	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.94558271
80	CJUN_26792858_Chip-Seq_BT549_Human	0.94426040
81	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.93798165
82	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.93653556
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92066543
84	TP53_16413492_ChIP-PET_HCT116_Human	0.92034567
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.92026722
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.91631026
87	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90791653
88	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.89437754
89	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.88818832
90	ATF3_27146783_Chip-Seq_COLON_Human	0.88123555
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.87834658
92	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.87007467
93	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86010219
94	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.85391513
95	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.84291962
96	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.84291962
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.84149489
98	GATA3_26560356_Chip-Seq_TH1_Human	0.82391723
99	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.81952636
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.81503028

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	5.53123404
2	MP0002822_catalepsy	5.18082159
3	MP0002736_abnormal_nociception_after	5.14973237
4	MP0005360_urolithiasis	4.15384204
5	MP0001666_abnormal_nutrient_absorption	3.47859551
6	MP0002163_abnormal_gland_morphology	3.42046092
7	MP0000613_abnormal_salivary_gland	3.33952649
8	MP0003693_abnormal_embryo_hatching	3.21075337
9	MP0001968_abnormal_touch/_nociception	3.20948307
10	MP0004264_abnormal_extraembryonic_tissu	3.14807183
11	MP0005220_abnormal_exocrine_pancreas	3.02620219
12	MP0002089_abnormal_postnatal_growth/wei	2.83390930
13	MP0010234_abnormal_vibrissa_follicle	2.59502249
14	MP0005379_endocrine/exocrine_gland_phen	2.49023137
15	MP0002139_abnormal_hepatobiliary_system	2.47580159
16	MP0003195_calcinosis	2.41049965
17	MP0009379_abnormal_foot_pigmentation	2.40881291
18	MP0004019_abnormal_vitamin_homeostasis	2.25785579
19	MP0000569_abnormal_digit_pigmentation	2.22812431
20	MP0004147_increased_porphyrin_level	2.05525308
21	MP0010352_gastrointestinal_tract_polyps	2.00251869
22	MP0005085_abnormal_gallbladder_physiolo	1.94123539
23	MP0000371_diluted_coat_color	1.93827429
24	MP0000858_altered_metastatic_potential	1.91215794
25	MP0005332_abnormal_amino_acid	1.87283479
26	MP0008260_abnormal_autophagy	1.76015986
27	MP0002877_abnormal_melanocyte_morpholog	1.69810960
28	MP0002796_impaired_skin_barrier	1.62004269
29	MP0008872_abnormal_physiological_respon	1.60384601
30	MP0005408_hypopigmentation	1.56746790
31	MP0005365_abnormal_bile_salt	1.56348417
32	MP0005451_abnormal_body_composition	1.51278699
33	MP0004957_abnormal_blastocyst_morpholog	1.48305360
34	MP0008995_early_reproductive_senescence	1.45033319
35	MP0000015_abnormal_ear_pigmentation	1.36216325
36	MP0005584_abnormal_enzyme/coenzyme_acti	1.34679495
37	MP0002733_abnormal_thermal_nociception	1.34258080
38	MP0005174_abnormal_tail_pigmentation	1.20316882
39	MP0002277_abnormal_respiratory_mucosa	1.17868087
40	MP0005409_darkened_coat_color	1.16345250
41	MP0003252_abnormal_bile_duct	1.16265829
42	MP0010155_abnormal_intestine_physiology	1.15291018
43	MP0008875_abnormal_xenobiotic_pharmacok	1.15284683
44	MP0005636_abnormal_mineral_homeostasis	1.13553178
45	MP0003959_abnormal_lean_body	1.11346706
46	MP0000490_abnormal_crypts_of	1.10707206
47	MP0005319_abnormal_enzyme/_coenzyme	1.09953068
48	MP0002075_abnormal_coat/hair_pigmentati	1.09748079
49	MP0003806_abnormal_nucleotide_metabolis	1.08834489
50	MP0002138_abnormal_hepatobiliary_system	1.07333926
51	MP0001765_abnormal_ion_homeostasis	1.05876495
52	MP0003786_premature_aging	1.01202643
53	MP0009643_abnormal_urine_homeostasis	1.00313147
54	MP0001756_abnormal_urination	0.97612421
55	MP0001186_pigmentation_phenotype	0.96427941
56	MP0010771_integument_phenotype	0.96111226
57	MP0003866_abnormal_defecation	0.94484124
58	MP0001663_abnormal_digestive_system	0.92382321
59	MP0008877_abnormal_DNA_methylation	0.91437519
60	MP0002098_abnormal_vibrissa_morphology	0.90992748
61	MP0005075_abnormal_melanosome_morpholog	0.89322330
62	MP0000470_abnormal_stomach_morphology	0.89081181
63	MP0000013_abnormal_adipose_tissue	0.87820125
64	MP0006035_abnormal_mitochondrial_morpho	0.87114694
65	MP0000427_abnormal_hair_cycle	0.86685278
66	MP0003300_gastrointestinal_ulcer	0.86266718
67	MP0003191_abnormal_cellular_cholesterol	0.85256821
68	MP0005501_abnormal_skin_physiology	0.80758713
69	MP0001664_abnormal_digestion	0.76855900
70	MP0000477_abnormal_intestine_morphology	0.75323491
71	MP0003638_abnormal_response/metabolism_	0.74129848
72	MP0000538_abnormal_urinary_bladder	0.73676554
73	MP0001764_abnormal_homeostasis	0.73541009
74	MP0009764_decreased_sensitivity_to	0.70026492
75	MP0001970_abnormal_pain_threshold	0.69402681
76	MP0003718_maternal_effect	0.69103099
77	MP0006082_CNS_inflammation	0.69046912
78	MP0010678_abnormal_skin_adnexa	0.67835638
79	MP0003868_abnormal_feces_composition	0.67785019
80	MP0000647_abnormal_sebaceous_gland	0.67737345
81	MP0005448_abnormal_energy_balance	0.67485421
82	MP0002909_abnormal_adrenal_gland	0.67189855
83	MP0003878_abnormal_ear_physiology	0.63756168
84	MP0005377_hearing/vestibular/ear_phenot	0.63756168
85	MP0000367_abnormal_coat/_hair	0.63506440
86	MP0004381_abnormal_hair_follicle	0.62913238
87	MP0004858_abnormal_nervous_system	0.62220453
88	MP0003953_abnormal_hormone_level	0.61043657
89	MP0002166_altered_tumor_susceptibility	0.60335169
90	MP0010329_abnormal_lipoprotein_level	0.58640047
91	MP0004484_altered_response_of	0.57089110
92	MP0003890_abnormal_embryonic-extraembry	0.56978038
93	MP0005381_digestive/alimentary_phenotyp	0.55108017
94	MP0005058_abnormal_lysosome_morphology	0.54817483
95	MP0009785_altered_susceptibility_to	0.54519725
96	MP0002136_abnormal_kidney_physiology	0.53951801
97	MP0009333_abnormal_splenocyte_physiolog	0.53612895
98	MP0010386_abnormal_urinary_bladder	0.52978456
99	MP0000383_abnormal_hair_follicle	0.49705377
100	MP0001188_hyperpigmentation	0.49666593

Predicted human phenotypes

Rank	Gene Set	Z-score
1	J-shaped sella turcica (HP:0002680)	5.87411128
2	Carpal bone hypoplasia (HP:0001498)	4.92542809
3	Thoracolumbar scoliosis (HP:0002944)	4.89574513
4	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.58896581
5	Abnormality of liposaccharide metabolism (HP:0010968)	4.22899552
6	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.22899552
7	Abnormality of glycolipid metabolism (HP:0010969)	4.22899552
8	Flat acetabular roof (HP:0003180)	4.12518047
9	Vertebral arch anomaly (HP:0008438)	3.85679358
10	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.76281885
11	Nausea (HP:0002018)	3.65709758
12	Diastasis recti (HP:0001540)	3.61634225
13	Congenital sensorineural hearing impairment (HP:0008527)	3.56507888
14	Malnutrition (HP:0004395)	3.55472749
15	Absent/shortened dynein arms (HP:0200106)	3.52277821
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.52277821
17	Tongue fasciculations (HP:0001308)	3.47811486
18	Proximal tubulopathy (HP:0000114)	3.44967674
19	Abnormality of proline metabolism (HP:0010907)	3.44022862
20	Hydroxyprolinuria (HP:0003080)	3.44022862
21	Urinary glycosaminoglycan excretion (HP:0003541)	3.29846963
22	Mucopolysacchariduria (HP:0008155)	3.29846963
23	Abnormality of mucopolysaccharide metabolism (HP:0011020)	3.25942678
24	Abnormality of polysaccharide metabolism (HP:0011012)	3.25942678
25	Abnormality of glycosaminoglycan metabolism (HP:0004371)	3.25942678
26	Abnormality of the lumbar spine (HP:0100712)	3.18439470
27	Broad ribs (HP:0000885)	3.15696714
28	Muscle fibrillation (HP:0010546)	3.08705644
29	Thoracic kyphosis (HP:0002942)	2.98205836
30	Broad alveolar ridges (HP:0000187)	2.95554119
31	Thickened calvaria (HP:0002684)	2.91157840
32	Steatorrhea (HP:0002570)	2.90441151
33	Deformed sella turcica (HP:0002681)	2.88233504
34	Abdominal distention (HP:0003270)	2.87705060
35	Hyperphosphatemia (HP:0002905)	2.87261120
36	Fat malabsorption (HP:0002630)	2.82533829
37	Vascular calcification (HP:0004934)	2.80446358
38	Flared iliac wings (HP:0002869)	2.78576760
39	Protuberant abdomen (HP:0001538)	2.75320695
40	Tetraparesis (HP:0002273)	2.73303533
41	Cone-rod dystrophy (HP:0000548)	2.67143325
42	Beaking of vertebral bodies (HP:0004568)	2.66782715
43	Recurrent bronchitis (HP:0002837)	2.43385701
44	Palpebral edema (HP:0100540)	2.39923716
45	Amelogenesis imperfecta (HP:0000705)	2.36864631
46	Pathologic fracture (HP:0002756)	2.36085098
47	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.35358014
48	Nonprogressive disorder (HP:0003680)	2.33463077
49	Death in childhood (HP:0003819)	2.27590966
50	Hypobetalipoproteinemia (HP:0003563)	2.26159120
51	Abnormal trabecular bone morphology (HP:0100671)	2.23559534
52	Cardiovascular calcification (HP:0011915)	2.22880896
53	Esophageal varix (HP:0002040)	2.22708933
54	Widely patent fontanelles and sutures (HP:0004492)	2.18863229
55	Abnormality of dental color (HP:0011073)	2.16792257
56	Subcapsular cataract (HP:0000523)	2.16079864
57	Decreased circulating renin level (HP:0003351)	2.15700622
58	Clumsiness (HP:0002312)	2.15415235
59	Aortic regurgitation (HP:0001659)	2.12917273
60	Bronchitis (HP:0012387)	2.10243550
61	Renal tubular acidosis (HP:0001947)	2.07916007
62	Alkalosis (HP:0001948)	2.05127034
63	Dysostosis multiplex (HP:0000943)	2.04032131
64	Abnormality of magnesium homeostasis (HP:0004921)	2.03220988
65	Abnormality of the thoracic spine (HP:0100711)	1.98924584
66	Hyperactive renin-angiotensin system (HP:0000841)	1.98199644
67	Hypoplastic scapulae (HP:0000882)	1.96695247
68	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.96695247
69	Unilateral renal agenesis (HP:0000122)	1.95753089
70	Hand muscle atrophy (HP:0009130)	1.95065776
71	Hoarse voice (HP:0001609)	1.93462737
72	Orthostatic hypotension (HP:0001278)	1.89409638
73	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.87878146
74	Recurrent pneumonia (HP:0006532)	1.87448731
75	Chronic diarrhea (HP:0002028)	1.84466983
76	Hyperammonemia (HP:0001987)	1.83090080
77	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.81678317
78	Rough bone trabeculation (HP:0100670)	1.80737396
79	Congenital ichthyosiform erythroderma (HP:0007431)	1.79553762
80	Posterior subcapsular cataract (HP:0007787)	1.79054785
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78799494
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.78799494
83	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.76551561
84	Infertility (HP:0000789)	1.75995542
85	Wide intermamillary distance (HP:0006610)	1.75037806
86	Stenosis of the external auditory canal (HP:0000402)	1.74405771
87	Hypotension (HP:0002615)	1.73803655
88	Abnormality of the sella turcica (HP:0002679)	1.73110070
89	Pancreatitis (HP:0001733)	1.72750905
90	Paraparesis (HP:0002385)	1.71646382
91	Tinnitus (HP:0000360)	1.69531570
92	Increased purine levels (HP:0004368)	1.69178591
93	Hyperuricemia (HP:0002149)	1.69178591
94	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.68650631
95	Abnormal auditory evoked potentials (HP:0006958)	1.67768440
96	Abnormality of the odontoid process (HP:0003310)	1.67555632
97	Congenital malformation of the right heart (HP:0011723)	1.67284323
98	Double outlet right ventricle (HP:0001719)	1.67284323
99	Glycosuria (HP:0003076)	1.67061084
100	Abnormality of urine glucose concentration (HP:0011016)	1.67061084

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	5.00887666
2	EPHA2	4.48760129
3	MST4	3.96855864
4	MAP3K2	3.05255841
5	ACVR1B	2.79774694
6	GRK6	2.58766001
7	MAP3K12	2.52542065
8	ERN1	2.44508970
9	PDK2	2.42800504
10	EIF2AK1	2.17058346
11	RPS6KB2	2.16329329
12	MAP2K3	2.07901736
13	PIK3CA	2.07468503
14	GRK5	1.97101402
15	PBK	1.72607028
16	PIK3CG	1.70896310
17	MST1R	1.69058855
18	MAP3K3	1.68918816
19	RPS6KA4	1.60816466
20	IRAK4	1.54681404
21	FGR	1.50667179
22	TAOK1	1.49763767
23	TLK1	1.45277478
24	MAP3K11	1.36879827
25	STK38L	1.28342438
26	MAP3K1	1.27062543
27	MAP2K6	1.26929136
28	FRK	1.25760722
29	STK24	1.22753732
30	IKBKE	1.20951960
31	TRIM28	1.20790750
32	STK4	1.19742048
33	OXSR1	1.18080486
34	EIF2AK3	1.17693153
35	MATK	1.12994398
36	BUB1	1.08902956
37	MET	1.07649073
38	MAP3K13	1.05811762
39	CAMK4	1.04027896
40	YES1	1.02410952
41	CAMK2G	1.01544038
42	STK39	1.00288781
43	DYRK3	0.99038787
44	MAP2K2	0.98839420
45	IRAK2	0.93379710
46	TBK1	0.91325621
47	GRK1	0.89664304
48	CAMK2D	0.89019185
49	MAP3K8	0.88864249
50	MELK	0.88208417
51	ADRBK2	0.86414848
52	STK16	0.85909385
53	SCYL2	0.85271843
54	TIE1	0.85250761
55	ZAK	0.84991245
56	TSSK6	0.83759606
57	LATS1	0.83202420
58	CAMK2B	0.77931130
59	NUAK1	0.76561345
60	EPHB1	0.75825272
61	TAOK2	0.74115547
62	PIM1	0.73255785
63	PTK2B	0.72666411
64	NME1	0.72312687
65	TESK1	0.70740912
66	MAP3K5	0.65773554
67	IKBKB	0.64526817
68	BCKDK	0.64198558
69	PTK6	0.62276813
70	FER	0.61059175
71	CDK6	0.57206461
72	TAOK3	0.56672705
73	CDK19	0.55887961
74	IRAK1	0.55554112
75	PRKCI	0.54172332
76	NEK1	0.50387476
77	VRK2	0.50231197
78	TNIK	0.48539928
79	ADRBK1	0.48069889
80	AURKB	0.47998854
81	CSNK1A1	0.47576412
82	MAP2K1	0.47323275
83	NLK	0.47246145
84	CAMKK2	0.46150573
85	RPS6KA5	0.45943745
86	PRKG2	0.45902636
87	NME2	0.45010902
88	LMTK2	0.43877061
89	CHUK	0.43533173
90	GRK7	0.41049546
91	EGFR	0.39843744
92	LRRK2	0.39117443
93	SIK3	0.37331594
94	STK10	0.36105361
95	KDR	0.32411254
96	NEK6	0.31182020
97	BRSK2	0.24998226
98	PDPK1	0.24832544
99	PAK4	0.24420156
100	CAMK2A	0.23942655

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.16001656
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.32527920
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.50002557
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.49851277
5	Glutathione metabolism_Homo sapiens_hsa00480	2.38400551
6	Cyanoamino acid metabolism_Homo sapiens_hsa00460	10.9333603
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.90971347
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.80120538
9	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.73406242
10	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.63480822
11	Pancreatic secretion_Homo sapiens_hsa04972	1.62182938
12	Protein digestion and absorption_Homo sapiens_hsa04974	1.47974783
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44905242
14	Renin-angiotensin system_Homo sapiens_hsa04614	1.44226605
15	Histidine metabolism_Homo sapiens_hsa00340	1.40907131
16	Sulfur metabolism_Homo sapiens_hsa00920	1.35537887
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.35324421
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.34950760
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31876590
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.28409430
21	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.24117784
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.19815205
23	Sulfur relay system_Homo sapiens_hsa04122	1.11880567
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.09967567
25	Fatty acid degradation_Homo sapiens_hsa00071	1.09113580
26	Nicotine addiction_Homo sapiens_hsa05033	1.09067207
27	Folate biosynthesis_Homo sapiens_hsa00790	1.02415123
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.97496048
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96041678
30	Proteasome_Homo sapiens_hsa03050	0.93962667
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92345124
32	Retinol metabolism_Homo sapiens_hsa00830	0.91132369
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87661124
34	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87064758
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86888035
36	Vibrio cholerae infection_Homo sapiens_hsa05110	0.82562986
37	Galactose metabolism_Homo sapiens_hsa00052	0.80301884
38	Fatty acid elongation_Homo sapiens_hsa00062	0.79676923
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.78523763
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.77613098
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77241172
42	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.72490496
43	Taste transduction_Homo sapiens_hsa04742	0.71296028
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70412891
45	Mineral absorption_Homo sapiens_hsa04978	0.70215972
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.67187767
47	Peroxisome_Homo sapiens_hsa04146	0.66445165
48	Caffeine metabolism_Homo sapiens_hsa00232	0.63399666
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61753262
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.58353116
51	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.54906607
52	Cocaine addiction_Homo sapiens_hsa05030	0.48934179
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47671902
54	Tight junction_Homo sapiens_hsa04530	0.45080956
55	Bile secretion_Homo sapiens_hsa04976	0.44681580
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.43132796
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.42822900
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42708885
59	Thyroid cancer_Homo sapiens_hsa05216	0.42187676
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42035547
61	Hepatitis C_Homo sapiens_hsa05160	0.41946660
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39718598
63	Metabolic pathways_Homo sapiens_hsa01100	0.38094064
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36420125
65	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.35937341
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.33627505
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.33602380
68	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.33124554
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.32524354
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31873492
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30463422
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.28586657
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28299667
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26309187
75	Lysosome_Homo sapiens_hsa04142	0.26074907
76	Serotonergic synapse_Homo sapiens_hsa04726	0.25149309
77	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.25039351
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24951091
79	Carbon metabolism_Homo sapiens_hsa01200	0.23237744
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.23061219
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.22934464
82	Amphetamine addiction_Homo sapiens_hsa05031	0.21717440
83	Tuberculosis_Homo sapiens_hsa05152	0.21317056
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.19260530
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.14016248
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.13590232
87	Regulation of autophagy_Homo sapiens_hsa04140	0.13488399
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.12282420
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.11675658
90	Alcoholism_Homo sapiens_hsa05034	0.11472775
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.10281049
92	Parkinsons disease_Homo sapiens_hsa05012	0.09744429
93	Ribosome_Homo sapiens_hsa03010	0.09541623
94	Leishmaniasis_Homo sapiens_hsa05140	0.09503630
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.09164760
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.08987897
97	Influenza A_Homo sapiens_hsa05164	0.07029210
98	Morphine addiction_Homo sapiens_hsa05032	0.05599948
99	Huntingtons disease_Homo sapiens_hsa05016	0.04935463
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.04786598

KRT8P35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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