ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	NADH metabolic process (GO:0006734)	4.92349799
2	desmosome organization (GO:0002934)	4.69163369
3	protein maturation by protein folding (GO:0022417)	4.64243348
4	positive regulation of pseudopodium assembly (GO:0031274)	4.45206465
5	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.24311417
6	regulation of guanylate cyclase activity (GO:0031282)	4.03150515
7	proteasome assembly (GO:0043248)	3.94558268
8	nucleoside diphosphate biosynthetic process (GO:0009133)	3.92529812
9	establishment of integrated proviral latency (GO:0075713)	3.91135736
10	regulation of pseudopodium assembly (GO:0031272)	3.90322461
11	ribosome assembly (GO:0042255)	3.90302054
12	GDP-mannose metabolic process (GO:0019673)	3.81087259
13	nucleotide-sugar biosynthetic process (GO:0009226)	3.76355663
14	positive regulation of actin filament depolymerization (GO:0030836)	3.66821747
15	establishment of viral latency (GO:0019043)	3.62774852
16	polyketide metabolic process (GO:0030638)	3.59797889
17	doxorubicin metabolic process (GO:0044598)	3.59797889
18	daunorubicin metabolic process (GO:0044597)	3.59797889
19	Golgi transport vesicle coating (GO:0048200)	3.54570147
20	COPI coating of Golgi vesicle (GO:0048205)	3.54570147
21	intestinal absorption (GO:0050892)	3.54550055
22	positive regulation of glycoprotein metabolic process (GO:1903020)	3.42972740
23	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.39283069
24	mitotic nuclear envelope reassembly (GO:0007084)	3.35388602
25	nuclear envelope reassembly (GO:0031468)	3.35388602
26	cobalamin metabolic process (GO:0009235)	3.26488347
27	regulation of metalloenzyme activity (GO:0048552)	3.25771459
28	cyclooxygenase pathway (GO:0019371)	3.21811438
29	renal system process involved in regulation of blood volume (GO:0001977)	3.16852936
30	galactose catabolic process (GO:0019388)	3.16304178
31	aminoglycoside antibiotic metabolic process (GO:0030647)	3.14129154
32	actin filament depolymerization (GO:0030042)	3.05165651
33	angiotensin maturation (GO:0002003)	3.03815207
34	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.99523617
35	protein retention in ER lumen (GO:0006621)	2.99017120
36	glutathione biosynthetic process (GO:0006750)	2.98439786
37	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.96484739
38	positive regulation of guanylate cyclase activity (GO:0031284)	2.95488136
39	nonribosomal peptide biosynthetic process (GO:0019184)	2.94695861
40	tricarboxylic acid cycle (GO:0006099)	2.92485793
41	regulation of cellular amino acid metabolic process (GO:0006521)	2.91383816
42	membrane budding (GO:0006900)	2.89841384
43	nucleobase-containing small molecule interconversion (GO:0015949)	2.88692421
44	cellular glucuronidation (GO:0052695)	2.86549897
45	endothelial tube morphogenesis (GO:0061154)	2.86519503
46	morphogenesis of an endothelium (GO:0003159)	2.86519503
47	uronic acid metabolic process (GO:0006063)	2.85769287
48	glucuronate metabolic process (GO:0019585)	2.85769287
49	galactose metabolic process (GO:0006012)	2.84525420
50	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.84193473
51	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.84098507
52	primary alcohol catabolic process (GO:0034310)	2.83164815
53	prostanoid metabolic process (GO:0006692)	2.82886738
54	prostaglandin metabolic process (GO:0006693)	2.82886738
55	prostaglandin biosynthetic process (GO:0001516)	2.82553906
56	prostanoid biosynthetic process (GO:0046457)	2.82553906
57	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.82000426
58	proline biosynthetic process (GO:0006561)	2.81683822
59	glycoside metabolic process (GO:0016137)	2.81374754
60	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.80314057
61	regulation of mitochondrial translation (GO:0070129)	2.79410760
62	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.77447193
63	digestion (GO:0007586)	2.74768977
64	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.69739644
65	hexose catabolic process (GO:0019320)	2.66532452
66	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.66523706
67	glycolipid catabolic process (GO:0019377)	2.66476674
68	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.66394128
69	hepatocyte apoptotic process (GO:0097284)	2.64749424
70	negative regulation of ligase activity (GO:0051352)	2.64703576
71	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.64703576
72	monosaccharide catabolic process (GO:0046365)	2.61707267
73	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.61104444
74	heterochromatin organization (GO:0070828)	2.60177715
75	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.59746582
76	nucleoside transmembrane transport (GO:1901642)	2.57730343
77	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.52770570
78	interferon-gamma secretion (GO:0072643)	2.51772976
79	positive regulation of epidermal cell differentiation (GO:0045606)	2.51502962
80	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.51390150
81	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.51390150
82	glutathione derivative metabolic process (GO:1901685)	2.50537298
83	glutathione derivative biosynthetic process (GO:1901687)	2.50537298
84	mitotic metaphase plate congression (GO:0007080)	2.50141342
85	gap junction assembly (GO:0016264)	2.49832951
86	tight junction assembly (GO:0070830)	2.49762348
87	regulation of translational termination (GO:0006449)	2.49460029
88	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.49150261
89	protein targeting to mitochondrion (GO:0006626)	2.48611403
90	vitamin transmembrane transport (GO:0035461)	2.48590297
91	epithelial cell-cell adhesion (GO:0090136)	2.47192235
92	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.46535112
93	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.46535112
94	endocrine process (GO:0050886)	2.46535112
95	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.46291909
96	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.46291909
97	formation of translation preinitiation complex (GO:0001731)	2.45731346
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.43686034
99	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.43686034
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.43686034

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.68913599
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.06397825
3	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.90980991
4	AR_21909140_ChIP-Seq_LNCAP_Human	2.89908441
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.74453828
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.70009444
7	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.60390548
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.58476882
9	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.46451800
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.42746089
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.36035491
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.34995673
13	E2F7_22180533_ChIP-Seq_HELA_Human	2.34881247
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.31086637
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.30016348
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.26936830
17	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.15052209
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.08306615
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.00824268
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97860425
21	GATA6_25053715_ChIP-Seq_YYC3_Human	1.97571125
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.91953773
23	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.88249003
24	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.85723502
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.83816151
26	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.82076506
27	GATA4_25053715_ChIP-Seq_YYC3_Human	1.75621688
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.74941508
29	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.74627269
30	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.72333081
31	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.71916211
32	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.71053607
33	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.70801001
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.66707257
35	RACK7_27058665_Chip-Seq_MCF-7_Human	1.64817068
36	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.63645891
37	SOX2_20726797_ChIP-Seq_SW620_Human	1.61753983
38	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.61435605
39	ATF3_27146783_Chip-Seq_COLON_Human	1.59967094
40	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.56633655
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54088914
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51151886
43	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.50634485
44	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.50462903
45	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.49798127
46	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.49096408
47	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.48249411
48	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.47734162
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.46527412
50	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.42472117
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.42119426
52	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.41700306
53	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37998802
54	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.36795867
55	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.36795867
56	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35589305
57	GABP_19822575_ChIP-Seq_HepG2_Human	1.34676171
58	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.33565745
59	CLOCK_20551151_ChIP-Seq_293T_Human	1.32667187
60	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.30843800
61	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.30719766
62	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.30395697
63	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.26034136
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25977648
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25312559
66	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.22697050
67	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.22504540
68	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.21575336
69	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.21235639
70	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.20738069
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.18718741
72	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18156723
73	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.16694296
74	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.16674852
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16321723
76	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.16003620
77	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.15738645
78	ELF5_23300383_ChIP-Seq_T47D_Human	1.15652779
79	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.15179243
80	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.14624830
81	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13224964
82	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.12545839
83	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.12335047
84	TTF2_22483619_ChIP-Seq_HELA_Human	1.12100491
85	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.12049997
86	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.10340633
87	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.09576724
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08869961
89	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.08844616
90	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.08535220
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06328821
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04330389
93	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.02204415
94	EOMES_21245162_ChIP-Seq_HESCs_Human	1.01337408
95	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.99227694
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.98214597
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.97157137
98	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.97029168
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96374416
100	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.95476273

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	6.36562818
2	MP0001666_abnormal_nutrient_absorption	3.65854586
3	MP0003693_abnormal_embryo_hatching	3.42156323
4	MP0004264_abnormal_extraembryonic_tissu	3.35236282
5	MP0000537_abnormal_urethra_morphology	3.31840560
6	MP0005360_urolithiasis	3.22030679
7	MP0010352_gastrointestinal_tract_polyps	3.17532397
8	MP0002796_impaired_skin_barrier	2.66007454
9	MP0002139_abnormal_hepatobiliary_system	2.49797492
10	MP0004957_abnormal_blastocyst_morpholog	2.48220191
11	MP0003806_abnormal_nucleotide_metabolis	2.39782842
12	MP0005365_abnormal_bile_salt	2.29986313
13	MP0003123_paternal_imprinting	2.29340481
14	MP0005085_abnormal_gallbladder_physiolo	2.18581430
15	MP0004019_abnormal_vitamin_homeostasis	2.18014068
16	MP0005501_abnormal_skin_physiology	2.07746132
17	MP0003566_abnormal_cell_adhesion	2.00534061
18	MP0004858_abnormal_nervous_system	1.97374035
19	MP0003315_abnormal_perineum_morphology	1.91296725
20	MP0000490_abnormal_crypts_of	1.89221205
21	MP0005367_renal/urinary_system_phenotyp	1.85702770
22	MP0000516_abnormal_urinary_system	1.85702770
23	MP0005451_abnormal_body_composition	1.83568357
24	MP0002877_abnormal_melanocyte_morpholog	1.78139301
25	MP0005083_abnormal_biliary_tract	1.70909341
26	MP0005257_abnormal_intraocular_pressure	1.61417748
27	MP0002098_abnormal_vibrissa_morphology	1.56381777
28	MP0000477_abnormal_intestine_morphology	1.50791221
29	MP0003786_premature_aging	1.48940788
30	MP0009379_abnormal_foot_pigmentation	1.46916187
31	MP0010030_abnormal_orbit_morphology	1.45297985
32	MP0008932_abnormal_embryonic_tissue	1.40602258
33	MP0003718_maternal_effect	1.36664036
34	MP0005332_abnormal_amino_acid	1.36383673
35	MP0010678_abnormal_skin_adnexa	1.35221792
36	MP0009840_abnormal_foam_cell	1.34999210
37	MP0008260_abnormal_autophagy	1.33155651
38	MP0000462_abnormal_digestive_system	1.32152217
39	MP0000762_abnormal_tongue_morphology	1.27266272
40	MP0004147_increased_porphyrin_level	1.22020259
41	MP0001730_embryonic_growth_arrest	1.21520661
42	MP0005670_abnormal_white_adipose	1.21120396
43	MP0004272_abnormal_basement_membrane	1.18298240
44	MP0000678_abnormal_parathyroid_gland	1.17283425
45	MP0001216_abnormal_epidermal_layer	1.16844499
46	MP0002060_abnormal_skin_morphology	1.16365256
47	MP0003077_abnormal_cell_cycle	1.14682531
48	MP0009643_abnormal_urine_homeostasis	1.14476179
49	MP0003191_abnormal_cellular_cholesterol	1.14146204
50	MP0003941_abnormal_skin_development	1.11559550
51	MP0003111_abnormal_nucleus_morphology	1.10033685
52	MP0005165_increased_susceptibility_to	1.08561424
53	MP0003866_abnormal_defecation	1.08420949
54	MP0006036_abnormal_mitochondrial_physio	1.03063842
55	MP0001765_abnormal_ion_homeostasis	1.02089609
56	MP0000538_abnormal_urinary_bladder	1.01188598
57	MP0008007_abnormal_cellular_replicative	1.00729008
58	MP0004782_abnormal_surfactant_physiolog	0.99872207
59	MP0001664_abnormal_digestion	0.98736682
60	MP0003119_abnormal_digestive_system	0.97572280
61	MP0001756_abnormal_urination	0.96671755
62	MP0003868_abnormal_feces_composition	0.95896132
63	MP0001243_abnormal_dermal_layer	0.95008119
64	MP0002138_abnormal_hepatobiliary_system	0.94234960
65	MP0000627_abnormal_mammary_gland	0.93927209
66	MP0000377_abnormal_hair_follicle	0.92901888
67	MP0001881_abnormal_mammary_gland	0.92292936
68	MP0010155_abnormal_intestine_physiology	0.91868422
69	MP0010771_integument_phenotype	0.91475930
70	MP0003453_abnormal_keratinocyte_physiol	0.90853378
71	MP0008875_abnormal_xenobiotic_pharmacok	0.89424142
72	MP0005636_abnormal_mineral_homeostasis	0.88426614
73	MP0005166_decreased_susceptibility_to	0.87902625
74	MP0001764_abnormal_homeostasis	0.87731322
75	MP0001849_ear_inflammation	0.86969093
76	MP0005330_cardiomyopathy	0.85259239
77	MP0000467_abnormal_esophagus_morphology	0.84386940
78	MP0000647_abnormal_sebaceous_gland	0.84252298
79	MP0008775_abnormal_heart_ventricle	0.80423929
80	MP0000566_synostosis	0.79381537
81	MP0002086_abnormal_extraembryonic_tissu	0.79042734
82	MP0009697_abnormal_copulation	0.78704360
83	MP0001672_abnormal_embryogenesis/_devel	0.78549375
84	MP0005380_embryogenesis_phenotype	0.78549375
85	MP0003950_abnormal_plasma_membrane	0.78439580
86	MP0005395_other_phenotype	0.77572659
87	MP0002136_abnormal_kidney_physiology	0.77561947
88	MP0010094_abnormal_chromosome_stability	0.76878972
89	MP0005058_abnormal_lysosome_morphology	0.76766297
90	MP0000350_abnormal_cell_proliferation	0.75296870
91	MP0005023_abnormal_wound_healing	0.74197252
92	MP0000858_altered_metastatic_potential	0.73198933
93	MP0005319_abnormal_enzyme/_coenzyme	0.72555643
94	MP0003984_embryonic_growth_retardation	0.72442890
95	MP0001873_stomach_inflammation	0.72208057
96	MP0002088_abnormal_embryonic_growth/wei	0.70189179
97	MP0002080_prenatal_lethality	0.69465787
98	MP0000613_abnormal_salivary_gland	0.69005751
99	MP0003638_abnormal_response/metabolism_	0.66906064
100	MP0008438_abnormal_cutaneous_collagen	0.66764450

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Right ventricular cardiomyopathy (HP:0011663)	4.43663790
2	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.38741918
3	Abnormality of the distal phalanges of the toes (HP:0010182)	3.77940005
4	Pili torti (HP:0003777)	3.08471366
5	Abnormality of proline metabolism (HP:0010907)	3.08180093
6	Hydroxyprolinuria (HP:0003080)	3.08180093
7	Vascular calcification (HP:0004934)	2.99740687
8	Abnormal tarsal ossification (HP:0008369)	2.94798379
9	Malnutrition (HP:0004395)	2.88277979
10	Increased serum pyruvate (HP:0003542)	2.82117116
11	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.80688464
12	Osteolytic defects of the hand bones (HP:0009699)	2.80688464
13	Abnormal hair laboratory examination (HP:0003328)	2.79494783
14	Reduced subcutaneous adipose tissue (HP:0003758)	2.77151082
15	Gout (HP:0001997)	2.73302218
16	Abnormality of glycolysis (HP:0004366)	2.73036433
17	Cardiovascular calcification (HP:0011915)	2.72063838
18	Type I transferrin isoform profile (HP:0003642)	2.72034533
19	Micronodular cirrhosis (HP:0001413)	2.68840610
20	Rough bone trabeculation (HP:0100670)	2.68308045
21	Fat malabsorption (HP:0002630)	2.67659848
22	Sparse eyelashes (HP:0000653)	2.65570779
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.64797130
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.64797130
25	Hyperactive renin-angiotensin system (HP:0000841)	2.60205559
26	Palpitations (HP:0001962)	2.59705023
27	Steatorrhea (HP:0002570)	2.55139294
28	Glycosuria (HP:0003076)	2.52595991
29	Abnormality of urine glucose concentration (HP:0011016)	2.52595991
30	Adrenal hypoplasia (HP:0000835)	2.47658011
31	Abnormality of the umbilical cord (HP:0010881)	2.46827282
32	Hepatic necrosis (HP:0002605)	2.45300465
33	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.44173844
34	Intrahepatic cholestasis (HP:0001406)	2.44099643
35	Abnormal trabecular bone morphology (HP:0100671)	2.43148284
36	Abdominal distention (HP:0003270)	2.42387245
37	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.36836923
38	Nausea (HP:0002018)	2.36499003
39	Lethargy (HP:0001254)	2.33570800
40	Hyperammonemia (HP:0001987)	2.32841481
41	Premature rupture of membranes (HP:0001788)	2.28698061
42	Hepatocellular necrosis (HP:0001404)	2.28634696
43	Microretrognathia (HP:0000308)	2.26206258
44	Reduced antithrombin III activity (HP:0001976)	2.25211034
45	Short nail (HP:0001799)	2.25176021
46	Megaloblastic anemia (HP:0001889)	2.25139194
47	Renal tubular acidosis (HP:0001947)	2.24600978
48	Abnormality of magnesium homeostasis (HP:0004921)	2.23455555
49	Metabolic alkalosis (HP:0200114)	2.20815936
50	Congenital ichthyosiform erythroderma (HP:0007431)	2.19922058
51	Alkalosis (HP:0001948)	2.19800137
52	Abnormality of vitamin B metabolism (HP:0004340)	2.19489482
53	Tongue fasciculations (HP:0001308)	2.16024856
54	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.15695161
55	Trismus (HP:0000211)	2.15071248
56	Abnormalities of placenta or umbilical cord (HP:0001194)	2.13180733
57	Ileus (HP:0002595)	2.13128888
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.13018634
59	Dicarboxylic aciduria (HP:0003215)	2.13018634
60	Abnormality of small intestinal villus morphology (HP:0011472)	2.12268080
61	Villous atrophy (HP:0011473)	2.12268080
62	Secondary amenorrhea (HP:0000869)	2.10945360
63	Unilateral renal agenesis (HP:0000122)	2.10176183
64	Insulin resistance (HP:0000855)	2.08562231
65	Late onset (HP:0003584)	2.07978591
66	Abnormality of renin-angiotensin system (HP:0000847)	2.07842383
67	Abnormality of the 1st metacarpal (HP:0010009)	2.07459566
68	Multiple lipomas (HP:0001012)	2.04948145
69	Distal lower limb muscle weakness (HP:0009053)	2.04238021
70	Abnormal protein glycosylation (HP:0012346)	2.02614713
71	Abnormal glycosylation (HP:0012345)	2.02614713
72	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.02614713
73	Abnormal protein N-linked glycosylation (HP:0012347)	2.02614713
74	Cerebral edema (HP:0002181)	1.99318137
75	Hyperuricemia (HP:0002149)	1.98568710
76	Increased purine levels (HP:0004368)	1.98568710
77	Confusion (HP:0001289)	1.98384923
78	Proximal tubulopathy (HP:0000114)	1.98136613
79	Posterior subcapsular cataract (HP:0007787)	1.97884002
80	Ureteral duplication (HP:0000073)	1.97406374
81	Glomerulosclerosis (HP:0000096)	1.95598262
82	Acute encephalopathy (HP:0006846)	1.94101532
83	Alopecia of scalp (HP:0002293)	1.93458499
84	Hyperglycinuria (HP:0003108)	1.93246801
85	Proximal placement of thumb (HP:0009623)	1.91359319
86	Distal lower limb amyotrophy (HP:0008944)	1.91004437
87	Abnormality of glycine metabolism (HP:0010895)	1.90635470
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.90635470
89	Hypoglycemic coma (HP:0001325)	1.90076435
90	Abnormality of serum amino acid levels (HP:0003112)	1.89084944
91	Metabolic acidosis (HP:0001942)	1.88865954
92	Hypobetalipoproteinemia (HP:0003563)	1.88710858
93	Generalized aminoaciduria (HP:0002909)	1.88221420
94	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87906465
95	Deviation of the thumb (HP:0009603)	1.86806348
96	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.86790598
97	Short 1st metacarpal (HP:0010034)	1.86790598
98	Abnormal foot bone ossification (HP:0010675)	1.86087274
99	Decreased circulating renin level (HP:0003351)	1.85893825
100	Progressive hearing impairment (HP:0001730)	1.85809973

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	6.34863223
2	MST1R	4.49988302
3	TESK1	3.44515119
4	MST4	3.22750231
5	VRK2	3.09201391
6	NME2	3.03096817
7	BUB1	2.64160656
8	TESK2	2.64000018
9	LIMK1	2.59373995
10	PBK	2.57203927
11	PAK4	2.46402985
12	PDK2	2.19710881
13	MAP3K12	2.14943175
14	LMTK2	2.13024868
15	NEK1	2.00414969
16	MET	1.97158782
17	EIF2AK1	1.92515446
18	ERN1	1.79825731
19	STK39	1.75314191
20	ACVR1B	1.67246970
21	TRIM28	1.52012990
22	RPS6KB2	1.44322046
23	STK16	1.43998075
24	SMG1	1.43880099
25	TSSK6	1.39824736
26	PRKG2	1.38876998
27	IRAK3	1.36172549
28	DAPK1	1.30578938
29	OXSR1	1.26575585
30	PTK2	1.21860360
31	ERBB4	1.16170902
32	ABL2	1.16137873
33	MYLK	1.14826957
34	SRPK1	1.13538929
35	STK10	1.09304338
36	FER	1.04579908
37	PLK4	1.03354696
38	TTK	1.02423269
39	PTK6	1.02406865
40	ILK	1.01498153
41	TNIK	0.97504577
42	EPHB2	0.97197172
43	PRKCI	0.94691134
44	MAPKAPK3	0.93187497
45	MAP3K8	0.88596406
46	PIM2	0.85967718
47	SIK3	0.83399138
48	BCKDK	0.82832279
49	AURKB	0.77591744
50	PIK3CA	0.76938057
51	KDR	0.74003573
52	CSNK1G3	0.70620230
53	SCYL2	0.69024522
54	ARAF	0.67684787
55	WEE1	0.67584972
56	CAMK2G	0.66030013
57	CAMK2D	0.65519099
58	PLK1	0.65179824
59	BRSK1	0.64481426
60	PLK3	0.61996393
61	TAOK1	0.61329843
62	CSNK1A1L	0.59466116
63	LRRK2	0.57599014
64	TAF1	0.55402233
65	BCR	0.54617757
66	RPS6KA4	0.53281666
67	RIPK1	0.52095981
68	EPHB1	0.50391351
69	MAP3K3	0.48477084
70	PAK1	0.48407094
71	CSNK1G1	0.48217685
72	BRAF	0.45814671
73	MAP2K2	0.45502803
74	CDK7	0.43651733
75	STK4	0.41177160
76	AKT2	0.40867836
77	MAP3K2	0.38650128
78	TAOK2	0.38538777
79	NME1	0.37210353
80	CAMK2B	0.36828503
81	VRK1	0.36255740
82	DAPK3	0.33786511
83	BRSK2	0.33705199
84	TRIB3	0.33399583
85	PASK	0.32881268
86	STK38L	0.31530504
87	MAPKAPK2	0.31475251
88	AURKA	0.31235651
89	TGFBR2	0.29954132
90	TLK1	0.27172288
91	STK24	0.26647161
92	EIF2AK2	0.25996282
93	EIF2AK3	0.25473572
94	CSNK1A1	0.23268059
95	CSNK1G2	0.20628518
96	MAP2K6	0.20412470
97	MAP2K1	0.18699878
98	GRK5	0.18597943
99	ALK	0.18512331
100	CSNK2A2	0.18434001

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.49167355
2	Proteasome_Homo sapiens_hsa03050	3.22318660
3	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.07456744
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.88720073
5	Sulfur metabolism_Homo sapiens_hsa00920	2.84469983
6	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.61018055
7	Glutathione metabolism_Homo sapiens_hsa00480	2.30046773
8	Sulfur relay system_Homo sapiens_hsa04122	2.13155707
9	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.07113414
10	Fatty acid elongation_Homo sapiens_hsa00062	2.02774165
11	Galactose metabolism_Homo sapiens_hsa00052	2.02093097
12	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.01610293
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.83333809
14	DNA replication_Homo sapiens_hsa03030	1.76263019
15	Folate biosynthesis_Homo sapiens_hsa00790	1.73645136
16	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.73452806
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.66830563
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.63626049
19	Renin-angiotensin system_Homo sapiens_hsa04614	1.61264092
20	Protein digestion and absorption_Homo sapiens_hsa04974	1.58812114
21	Carbon metabolism_Homo sapiens_hsa01200	1.56096390
22	Pentose phosphate pathway_Homo sapiens_hsa00030	1.55434582
23	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.53675091
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.52639086
25	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.50558702
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.47953801
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.44735158
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.42877428
29	Pancreatic secretion_Homo sapiens_hsa04972	1.41924996
30	Mineral absorption_Homo sapiens_hsa04978	1.41614237
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.39126296
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.35537530
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34880664
34	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.32907638
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32531112
36	Mismatch repair_Homo sapiens_hsa03430	1.29087467
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28796794
38	Histidine metabolism_Homo sapiens_hsa00340	1.26045952
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25374771
40	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22349701
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21555458
42	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.21430474
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.14665067
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14335012
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.12820669
46	Fatty acid degradation_Homo sapiens_hsa00071	1.10561225
47	Vibrio cholerae infection_Homo sapiens_hsa05110	1.06389453
48	Phenylalanine metabolism_Homo sapiens_hsa00360	1.05721245
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03450458
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02333082
51	Base excision repair_Homo sapiens_hsa03410	1.01083139
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99862470
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96500021
54	Retinol metabolism_Homo sapiens_hsa00830	0.96304126
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95769275
56	Parkinsons disease_Homo sapiens_hsa05012	0.92835208
57	Caffeine metabolism_Homo sapiens_hsa00232	0.87315535
58	Propanoate metabolism_Homo sapiens_hsa00640	0.87045117
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.86007745
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85922412
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84443677
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.84216836
63	Ribosome_Homo sapiens_hsa03010	0.83916808
64	Other glycan degradation_Homo sapiens_hsa00511	0.83419863
65	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.81624608
66	Tight junction_Homo sapiens_hsa04530	0.80089041
67	Bile secretion_Homo sapiens_hsa04976	0.79488534
68	Huntingtons disease_Homo sapiens_hsa05016	0.77226957
69	Metabolic pathways_Homo sapiens_hsa01100	0.76347888
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.70673953
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.69873950
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68408171
73	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68381392
74	Purine metabolism_Homo sapiens_hsa00230	0.67171531
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66201196
76	RNA transport_Homo sapiens_hsa03013	0.64074412
77	Alzheimers disease_Homo sapiens_hsa05010	0.63966344
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.62730511
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.61237578
80	One carbon pool by folate_Homo sapiens_hsa00670	0.58495173
81	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.57523739
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54152846
83	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.53551728
84	Thyroid cancer_Homo sapiens_hsa05216	0.52191599
85	RNA polymerase_Homo sapiens_hsa03020	0.51613971
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48570375
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.47161985
88	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.46019856
89	Peroxisome_Homo sapiens_hsa04146	0.43908708
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43086611
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.42593340
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.40311779
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.39576123
94	Spliceosome_Homo sapiens_hsa03040	0.38952878
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38824527
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.38680780
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.35940867
98	Cell cycle_Homo sapiens_hsa04110	0.35566758
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35225197
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.34154912

KRT8P36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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