ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA replication checkpoint (GO:0000076)	4.93778410
2	CENP-A containing nucleosome assembly (GO:0034080)	4.50796299
3	chromatin remodeling at centromere (GO:0031055)	4.42279844
4	nuclear pore complex assembly (GO:0051292)	4.30896988
5	regulation of centriole replication (GO:0046599)	4.27384445
6	DNA replication-dependent nucleosome assembly (GO:0006335)	4.11546142
7	DNA replication-dependent nucleosome organization (GO:0034723)	4.11546142
8	protein localization to kinetochore (GO:0034501)	4.10376296
9	nuclear pore organization (GO:0006999)	4.04026905
10	mRNA cleavage (GO:0006379)	3.85015942
11	regulation of mitochondrial translation (GO:0070129)	3.82331961
12	response to food (GO:0032094)	3.78838039
13	mitotic sister chromatid cohesion (GO:0007064)	3.76067244
14	ribosome assembly (GO:0042255)	3.66989510
15	DNA replication-independent nucleosome assembly (GO:0006336)	3.65342794
16	DNA replication-independent nucleosome organization (GO:0034724)	3.65342794
17	DNA strand elongation (GO:0022616)	3.65006845
18	DNA ligation (GO:0006266)	3.63337466
19	transcription from mitochondrial promoter (GO:0006390)	3.59690963
20	telomere maintenance via semi-conservative replication (GO:0032201)	3.55985159
21	DNA strand elongation involved in DNA replication (GO:0006271)	3.54842760
22	histone exchange (GO:0043486)	3.54742376
23	telomere maintenance via recombination (GO:0000722)	3.45033375
24	mitochondrial RNA metabolic process (GO:0000959)	3.44834564
25	mitotic metaphase plate congression (GO:0007080)	3.43505861
26	sister chromatid segregation (GO:0000819)	3.34705706
27	non-recombinational repair (GO:0000726)	3.33643305
28	double-strand break repair via nonhomologous end joining (GO:0006303)	3.33643305
29	regulation of helicase activity (GO:0051095)	3.30333080
30	inner mitochondrial membrane organization (GO:0007007)	3.29927127
31	DNA double-strand break processing (GO:0000729)	3.29591312
32	pore complex assembly (GO:0046931)	3.29181604
33	metaphase plate congression (GO:0051310)	3.25605657
34	mitotic recombination (GO:0006312)	3.24377680
35	mitotic nuclear envelope disassembly (GO:0007077)	3.21091801
36	kinetochore organization (GO:0051383)	3.20251676
37	protein localization to chromosome, centromeric region (GO:0071459)	3.17399553
38	prenylation (GO:0097354)	3.12958837
39	protein prenylation (GO:0018342)	3.12958837
40	mitotic G2/M transition checkpoint (GO:0044818)	3.11488799
41	mitotic sister chromatid segregation (GO:0000070)	3.08760106
42	growth hormone secretion (GO:0030252)	3.08173004
43	regulation of mitotic spindle checkpoint (GO:1903504)	3.07574687
44	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.07574687
45	pseudouridine synthesis (GO:0001522)	3.04695990
46	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.01424844
47	mitotic chromosome condensation (GO:0007076)	3.00806081
48	meiotic chromosome segregation (GO:0045132)	2.99590392
49	establishment of integrated proviral latency (GO:0075713)	2.99205824
50	female gonad development (GO:0008585)	2.97827500
51	ribosomal large subunit biogenesis (GO:0042273)	2.97170717
52	pre-miRNA processing (GO:0031054)	2.97160951
53	maturation of 5.8S rRNA (GO:0000460)	2.93317931
54	proteasome assembly (GO:0043248)	2.91318370
55	regulation of centrosome cycle (GO:0046605)	2.91005178
56	DNA replication initiation (GO:0006270)	2.90897035
57	regulation of centrosome duplication (GO:0010824)	2.90766165
58	telomere maintenance via telomere lengthening (GO:0010833)	2.89508459
59	formation of translation preinitiation complex (GO:0001731)	2.88805117
60	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.88031429
61	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.88031429
62	ribosome biogenesis (GO:0042254)	2.86979078
63	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.84130716
64	centriole replication (GO:0007099)	2.83272003
65	telomere maintenance (GO:0000723)	2.80888630
66	chromatin assembly or disassembly (GO:0006333)	2.80271807
67	telomere organization (GO:0032200)	2.79782219
68	nuclear envelope disassembly (GO:0051081)	2.79607067
69	membrane disassembly (GO:0030397)	2.79607067
70	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.78393456
71	galactose catabolic process (GO:0019388)	2.78171853
72	IMP biosynthetic process (GO:0006188)	2.77075710
73	telomere maintenance via telomerase (GO:0007004)	2.76798808
74	folic acid-containing compound biosynthetic process (GO:0009396)	2.75069117
75	DNA damage response, detection of DNA damage (GO:0042769)	2.73163410
76	ribonucleoprotein complex biogenesis (GO:0022613)	2.71914181
77	kinetochore assembly (GO:0051382)	2.70559288
78	base-excision repair, AP site formation (GO:0006285)	2.68553737
79	DNA geometric change (GO:0032392)	2.68058370
80	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.67364593
81	DNA duplex unwinding (GO:0032508)	2.65551524
82	recombinational repair (GO:0000725)	2.65298629
83	pteridine-containing compound biosynthetic process (GO:0042559)	2.65028742
84	double-strand break repair via homologous recombination (GO:0000724)	2.64086988
85	negative regulation of DNA recombination (GO:0045910)	2.63248392
86	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.62008402
87	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.61636601
88	establishment of viral latency (GO:0019043)	2.61206945
89	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.58899758
90	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.58899758
91	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58819278
92	isotype switching (GO:0045190)	2.58819278
93	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58819278
94	respiratory chain complex IV assembly (GO:0008535)	2.58680812
95	termination of RNA polymerase I transcription (GO:0006363)	2.57551786
96	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.55016998
97	replication fork processing (GO:0031297)	2.54551626
98	regulation of DNA-dependent DNA replication (GO:0090329)	2.53821211
99	regulation of growth hormone secretion (GO:0060123)	2.53034306
100	positive regulation of chromosome segregation (GO:0051984)	2.52038970

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.34988272
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.84148112
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.24317399
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12561720
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.05292107
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.70407482
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22148942
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.21211226
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.19492994
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.91312123
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86331436
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.85105649
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.65858048
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.61817568
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.52868730
16	AR_21909140_ChIP-Seq_LNCAP_Human	2.52175255
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.41691457
18	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.41316079
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.41021203
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.37546868
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.31199845
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30160254
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.21127861
24	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.18502729
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14754367
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.14049372
27	VDR_23849224_ChIP-Seq_CD4+_Human	2.09965385
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.07433715
29	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.99395264
30	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.98690500
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.95480830
32	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.93053829
33	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.91377115
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91374416
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.89542717
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.85608744
37	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.85560207
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.84751451
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.81641981
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.77686479
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.75751230
42	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.71577921
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.70796361
44	KDM5A_27292631_Chip-Seq_BREAST_Human	1.66794928
45	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.65863835
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.63646657
47	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.61036282
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49668807
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48364402
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.47350351
51	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.47055614
52	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.44742663
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34770854
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33260761
55	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.31670820
56	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.29798899
57	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.27755235
58	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.24422346
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21701183
60	EWS_26573619_Chip-Seq_HEK293_Human	1.20845714
61	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.20658687
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.19695177
63	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.16854152
64	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.15737601
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.11374397
66	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.09732875
67	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.09590086
68	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.08159354
69	GATA6_25053715_ChIP-Seq_YYC3_Human	1.07240529
70	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.04076728
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.03805327
72	GATA1_22025678_ChIP-Seq_K562_Human	0.97450638
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96432100
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.94945943
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89703870
76	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.86269888
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.85703522
78	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.85373730
79	ZNF263_19887448_ChIP-Seq_K562_Human	0.84586236
80	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.83915025
81	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.83611858
82	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.82902736
83	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.80250312
84	ELF5_23300383_ChIP-Seq_T47D_Human	0.80037644
85	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.79234574
86	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.78757636
87	CHD1_26751641_Chip-Seq_LNCaP_Human	0.78578761
88	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.77006733
89	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.75864186
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.75025057
91	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.74962280
92	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.74559674
93	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.72996917
94	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.72053113
95	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.71982952
96	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.71745832
97	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.70841204
98	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.70066139
99	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.69844187
100	EOMES_21245162_ChIP-Seq_HESCs_Human	0.69748128

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.46974099
2	MP0010094_abnormal_chromosome_stability	4.35334109
3	MP0004957_abnormal_blastocyst_morpholog	3.62539567
4	MP0008057_abnormal_DNA_replication	3.43795024
5	MP0008058_abnormal_DNA_repair	3.31138270
6	MP0003941_abnormal_skin_development	3.25473988
7	MP0003111_abnormal_nucleus_morphology	2.99727560
8	MP0005083_abnormal_biliary_tract	2.89230818
9	MP0003890_abnormal_embryonic-extraembry	2.87982929
10	MP0003077_abnormal_cell_cycle	2.81786926
11	MP0001986_abnormal_taste_sensitivity	2.41296695
12	MP0002254_reproductive_system_inflammat	2.24387823
13	MP0002102_abnormal_ear_morphology	2.23323163
14	MP0002396_abnormal_hematopoietic_system	2.22405330
15	MP0002938_white_spotting	2.17795095
16	MP0008932_abnormal_embryonic_tissue	2.17453958
17	MP0006035_abnormal_mitochondrial_morpho	2.04587113
18	MP0003786_premature_aging	1.99033396
19	MP0008007_abnormal_cellular_replicative	1.91272250
20	MP0009697_abnormal_copulation	1.89246362
21	MP0003718_maternal_effect	1.82892243
22	MP0010352_gastrointestinal_tract_polyps	1.82721869
23	MP0002160_abnormal_reproductive_system	1.74334945
24	MP0001293_anophthalmia	1.71540452
25	MP0010234_abnormal_vibrissa_follicle	1.60529897
26	MP0004264_abnormal_extraembryonic_tissu	1.59360435
27	MP0003806_abnormal_nucleotide_metabolis	1.56825401
28	MP0001697_abnormal_embryo_size	1.55059361
29	MP0005076_abnormal_cell_differentiation	1.53193185
30	MP0001730_embryonic_growth_arrest	1.49629293
31	MP0001672_abnormal_embryogenesis/_devel	1.46856075
32	MP0005380_embryogenesis_phenotype	1.46856075
33	MP0003984_embryonic_growth_retardation	1.41545185
34	MP0002088_abnormal_embryonic_growth/wei	1.38315826
35	MP0001666_abnormal_nutrient_absorption	1.33267276
36	MP0003119_abnormal_digestive_system	1.32190763
37	MP0002084_abnormal_developmental_patter	1.30573892
38	MP0005220_abnormal_exocrine_pancreas	1.28999924
39	MP0006292_abnormal_olfactory_placode	1.27362567
40	MP0002111_abnormal_tail_morphology	1.26624987
41	MP0000358_abnormal_cell_content/	1.20790955
42	MP0004197_abnormal_fetal_growth/weight/	1.18462189
43	MP0001286_abnormal_eye_development	1.17049132
44	MP0009672_abnormal_birth_weight	1.16730418
45	MP0002080_prenatal_lethality	1.15568544
46	MP0002085_abnormal_embryonic_tissue	1.15525323
47	MP0000383_abnormal_hair_follicle	1.14684159
48	MP0000350_abnormal_cell_proliferation	1.13846144
49	MP0000537_abnormal_urethra_morphology	1.13672828
50	MP0002697_abnormal_eye_size	1.13611014
51	MP0002086_abnormal_extraembryonic_tissu	1.13505239
52	MP0010678_abnormal_skin_adnexa	1.13235305
53	MP0003937_abnormal_limbs/digits/tail_de	1.12154773
54	MP0006036_abnormal_mitochondrial_physio	1.10331130
55	MP0002796_impaired_skin_barrier	1.10239231
56	MP0008875_abnormal_xenobiotic_pharmacok	1.09738200
57	MP0005266_abnormal_metabolism	1.05652496
58	MP0003123_paternal_imprinting	1.05414951
59	MP0005501_abnormal_skin_physiology	1.05399966
60	MP0009703_decreased_birth_body	1.03500312
61	MP0008995_early_reproductive_senescence	1.02603594
62	MP0005367_renal/urinary_system_phenotyp	0.97485434
63	MP0000516_abnormal_urinary_system	0.97485434
64	MP0003567_abnormal_fetal_cardiomyocyte	0.95308473
65	MP0003136_yellow_coat_color	0.94860298
66	MP0001529_abnormal_vocalization	0.90899139
67	MP0001764_abnormal_homeostasis	0.90437840
68	MP0010030_abnormal_orbit_morphology	0.89464007
69	MP0005389_reproductive_system_phenotype	0.88207962
70	MP0004019_abnormal_vitamin_homeostasis	0.87906997
71	MP0003195_calcinosis	0.86881835
72	MP0002019_abnormal_tumor_incidence	0.85998001
73	MP0010307_abnormal_tumor_latency	0.85676323
74	MP0003303_peritoneal_inflammation	0.85650883
75	MP0004147_increased_porphyrin_level	0.85427006
76	MP0002060_abnormal_skin_morphology	0.85271070
77	MP0005174_abnormal_tail_pigmentation	0.83047053
78	MP0008877_abnormal_DNA_methylation	0.82772642
79	MP0001929_abnormal_gametogenesis	0.82466390
80	MP0000313_abnormal_cell_death	0.80461289
81	MP0002210_abnormal_sex_determination	0.80367940
82	MP0001145_abnormal_male_reproductive	0.80217519
83	MP0005499_abnormal_olfactory_system	0.79366299
84	MP0005394_taste/olfaction_phenotype	0.79366299
85	MP0000579_abnormal_nail_morphology	0.78609173
86	MP0001119_abnormal_female_reproductive	0.77887750
87	MP0001661_extended_life_span	0.76401935
88	MP0008789_abnormal_olfactory_epithelium	0.75228084
89	MP0002233_abnormal_nose_morphology	0.75087670
90	MP0000653_abnormal_sex_gland	0.74601555
91	MP0001485_abnormal_pinna_reflex	0.73692416
92	MP0001188_hyperpigmentation	0.73334689
93	MP0001270_distended_abdomen	0.73014801
94	MP0000015_abnormal_ear_pigmentation	0.71345373
95	MP0002177_abnormal_outer_ear	0.69988516
96	MP0000762_abnormal_tongue_morphology	0.69601997
97	MP0000428_abnormal_craniofacial_morphol	0.67732173
98	MP0005365_abnormal_bile_salt	0.67478492
99	MP0005075_abnormal_melanosome_morpholog	0.67325473
100	MP0004134_abnormal_chest_morphology	0.66988946

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	4.90971344
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.61809175
3	Abnormality of chromosome stability (HP:0003220)	3.64790798
4	Pancreatic islet-cell hyperplasia (HP:0004510)	3.24671929
5	Abnormality of the preputium (HP:0100587)	3.23077798
6	Meckel diverticulum (HP:0002245)	3.16816914
7	Birth length less than 3rd percentile (HP:0003561)	3.12547841
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.09719782
9	Abnormality of the ileum (HP:0001549)	3.02992751
10	Microvesicular hepatic steatosis (HP:0001414)	3.00651183
11	Hypoglycemic seizures (HP:0002173)	2.85470943
12	Bifid tongue (HP:0010297)	2.74200494
13	Anal stenosis (HP:0002025)	2.67269874
14	Bilateral microphthalmos (HP:0007633)	2.62222498
15	Abnormality of the pancreatic islet cells (HP:0006476)	2.58315028
16	Abnormality of endocrine pancreas physiology (HP:0012093)	2.58315028
17	Ectopic kidney (HP:0000086)	2.53382164
18	Hyperinsulinemic hypoglycemia (HP:0000825)	2.51750531
19	Abnormal pancreas size (HP:0012094)	2.49915848
20	Type I transferrin isoform profile (HP:0003642)	2.45390414
21	Sloping forehead (HP:0000340)	2.45304560
22	Clubbing of toes (HP:0100760)	2.42530828
23	Reduced antithrombin III activity (HP:0001976)	2.36448244
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.35533833
25	Lipid accumulation in hepatocytes (HP:0006561)	2.35313783
26	Premature ovarian failure (HP:0008209)	2.32023455
27	Abnormality of methionine metabolism (HP:0010901)	2.31262721
28	Reticulocytopenia (HP:0001896)	2.29961770
29	Enlarged kidneys (HP:0000105)	2.28483994
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.27416371
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.27416371
32	Abnormal protein glycosylation (HP:0012346)	2.27416371
33	Abnormal glycosylation (HP:0012345)	2.27416371
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26650755
35	Abnormality of alanine metabolism (HP:0010916)	2.26650755
36	Hyperalaninemia (HP:0003348)	2.26650755
37	Hypoglycemic coma (HP:0001325)	2.24346583
38	Prominent metopic ridge (HP:0005487)	2.21175172
39	Absent radius (HP:0003974)	2.20426215
40	Small intestinal stenosis (HP:0012848)	2.20203857
41	Duodenal stenosis (HP:0100867)	2.20203857
42	Abnormal lung lobation (HP:0002101)	2.15712667
43	Abnormality of the duodenum (HP:0002246)	2.15318863
44	Microretrognathia (HP:0000308)	2.14977118
45	Symptomatic seizures (HP:0011145)	2.12876129
46	Nephroblastoma (Wilms tumor) (HP:0002667)	2.11397212
47	Squamous cell carcinoma (HP:0002860)	2.10182024
48	Neoplasm of the adrenal cortex (HP:0100641)	2.10018451
49	Abnormality of DNA repair (HP:0003254)	2.09383748
50	Progressive muscle weakness (HP:0003323)	2.09113915
51	Epidermoid cyst (HP:0200040)	2.09004517
52	Intestinal atresia (HP:0011100)	2.08953552
53	Aplasia involving forearm bones (HP:0009822)	2.06034998
54	Absent forearm bone (HP:0003953)	2.06034998
55	Horseshoe kidney (HP:0000085)	2.05696364
56	Hypobetalipoproteinemia (HP:0003563)	2.05595564
57	Absent thumb (HP:0009777)	2.03856412
58	Embryonal renal neoplasm (HP:0011794)	2.03169939
59	Anophthalmia (HP:0000528)	2.02317709
60	Poikiloderma (HP:0001029)	2.01939750
61	Abnormality of serum amino acid levels (HP:0003112)	2.01880150
62	Multiple enchondromatosis (HP:0005701)	2.01464983
63	Abnormality of pyrimidine metabolism (HP:0004353)	2.01144473
64	Homocystinuria (HP:0002156)	2.00549043
65	Abnormality of homocysteine metabolism (HP:0010919)	2.00549043
66	Increased hepatocellular lipid droplets (HP:0006565)	2.00470876
67	Short thumb (HP:0009778)	1.97678890
68	Pendular nystagmus (HP:0012043)	1.96435015
69	Hypergonadotropic hypogonadism (HP:0000815)	1.95319846
70	Increased CSF lactate (HP:0002490)	1.94116546
71	Megaloblastic anemia (HP:0001889)	1.93630015
72	Volvulus (HP:0002580)	1.92565928
73	Hepatocellular necrosis (HP:0001404)	1.88539064
74	Abnormal biliary tract physiology (HP:0012439)	1.87710454
75	Bile duct proliferation (HP:0001408)	1.87710454
76	Abnormality of the carotid arteries (HP:0005344)	1.87301765
77	Abnormality of the metopic suture (HP:0005556)	1.86009629
78	Facial cleft (HP:0002006)	1.85713160
79	Triphalangeal thumb (HP:0001199)	1.85299168
80	Neoplasm of the adrenal gland (HP:0100631)	1.83164437
81	Small hand (HP:0200055)	1.83121329
82	Ependymoma (HP:0002888)	1.81363745
83	Cleft eyelid (HP:0000625)	1.80876817
84	Secondary amenorrhea (HP:0000869)	1.80480942
85	Methylmalonic aciduria (HP:0012120)	1.79497549
86	Myelodysplasia (HP:0002863)	1.79491444
87	Duplicated collecting system (HP:0000081)	1.79057298
88	Hypoplasia of the pons (HP:0012110)	1.77377536
89	Abnormality of the parathyroid morphology (HP:0011766)	1.76132512
90	Increased serum lactate (HP:0002151)	1.75285307
91	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74896571
92	Anal atresia (HP:0002023)	1.74463903
93	Abnormality of the lacrimal duct (HP:0011481)	1.74170634
94	Rib fusion (HP:0000902)	1.72727172
95	Proximal placement of thumb (HP:0009623)	1.72195788
96	Choanal atresia (HP:0000453)	1.69804929
97	Intestinal fistula (HP:0100819)	1.69691630
98	Abnormality of the nasal septum (HP:0000419)	1.68203050
99	Hepatic necrosis (HP:0002605)	1.66923719
100	Rectal fistula (HP:0100590)	1.66382677

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	3.82586374
2	LATS1	3.52375884
3	PDK2	3.36465195
4	CDC7	3.33807758
5	ACVR1B	3.12868282
6	NUAK1	3.09626266
7	PLK4	2.86361078
8	TLK1	2.60239651
9	ZAK	2.51915733
10	MST4	2.42269057
11	NEK1	2.39882786
12	TRIM28	2.22993971
13	MKNK2	2.19409124
14	TESK2	2.18221319
15	SRPK1	2.10877400
16	EIF2AK1	2.03195328
17	EPHA2	2.01537680
18	WEE1	1.95348754
19	EIF2AK3	1.94620169
20	STK16	1.89375691
21	RPS6KB2	1.77685375
22	TNIK	1.74848767
23	TTK	1.71815183
24	PIM2	1.68045452
25	MST1R	1.67808964
26	NEK2	1.66481869
27	BUB1	1.63015866
28	VRK2	1.54104315
29	FRK	1.53255656
30	NME1	1.45954606
31	TSSK6	1.44348763
32	MKNK1	1.44276919
33	BMPR1B	1.41285801
34	PLK1	1.39034302
35	VRK1	1.37047063
36	AURKB	1.27172104
37	MAP3K10	1.27162057
38	PLK3	1.14395305
39	CDK12	1.11667207
40	BRSK2	1.07998970
41	STK3	1.06915257
42	ATR	0.98409596
43	CHEK2	0.97333856
44	EIF2AK2	0.95177001
45	CDK7	0.94986992
46	STK39	0.93370533
47	BRD4	0.92314676
48	OXSR1	0.90600926
49	STK4	0.89491044
50	GRK1	0.87583037
51	CHEK1	0.85823613
52	SCYL2	0.84998716
53	CSNK1G1	0.84821855
54	PASK	0.81807098
55	SIK3	0.80145505
56	ERBB4	0.73955397
57	MELK	0.72877849
58	ATM	0.72175131
59	TAF1	0.71886525
60	NME2	0.71843505
61	MAP3K8	0.69067424
62	CLK1	0.67538943
63	RPS6KA5	0.65776870
64	NEK6	0.62525953
65	AURKA	0.57419841
66	TGFBR1	0.55745314
67	WNK4	0.53201152
68	CSNK1A1L	0.51167664
69	BRSK1	0.49896099
70	CSNK1G3	0.49816677
71	LMTK2	0.49259332
72	MET	0.48610863
73	PIM1	0.47293418
74	RPS6KA4	0.44606506
75	STK10	0.43414106
76	ERBB3	0.42651870
77	CDK1	0.42317441
78	BCKDK	0.41683625
79	CDK2	0.41471164
80	TIE1	0.40630436
81	MAPKAPK3	0.40503250
82	SIK1	0.40429910
83	NLK	0.38613437
84	PAK4	0.38004716
85	MTOR	0.36781315
86	WNK3	0.34047090
87	CDK3	0.33922945
88	FGFR2	0.33658388
89	CSNK2A2	0.33162518
90	CSNK1E	0.32734375
91	CSNK2A1	0.31421154
92	CAMK1G	0.28393449
93	FGFR1	0.26773885
94	ALK	0.26358660
95	PAK2	0.24397881
96	ICK	0.24280925
97	MATK	0.24251346
98	PRKAA1	0.22819589
99	PIK3CA	0.21356201
100	PRKCI	0.21303930

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.47972860
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.37260964
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.29535275
4	Mismatch repair_Homo sapiens_hsa03430	3.26386970
5	Homologous recombination_Homo sapiens_hsa03440	2.92702695
6	Proteasome_Homo sapiens_hsa03050	2.82439988
7	RNA polymerase_Homo sapiens_hsa03020	2.72423580
8	Base excision repair_Homo sapiens_hsa03410	2.49458007
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48582287
10	One carbon pool by folate_Homo sapiens_hsa00670	2.38751871
11	RNA transport_Homo sapiens_hsa03013	2.24088546
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.11502345
13	Ribosome_Homo sapiens_hsa03010	1.80338902
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.80044510
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.79167681
16	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.75714427
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71619385
18	Spliceosome_Homo sapiens_hsa03040	1.68801065
19	Glutathione metabolism_Homo sapiens_hsa00480	1.63539668
20	Cell cycle_Homo sapiens_hsa04110	1.58457607
21	RNA degradation_Homo sapiens_hsa03018	1.58240225
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.57341988
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.57109042
24	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.57066183
25	Folate biosynthesis_Homo sapiens_hsa00790	1.55890647
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.54877785
27	Fatty acid elongation_Homo sapiens_hsa00062	1.52347074
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37772939
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36828633
30	Propanoate metabolism_Homo sapiens_hsa00640	1.36304224
31	Basal transcription factors_Homo sapiens_hsa03022	1.35727395
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.34630904
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.28080316
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27243093
35	Caffeine metabolism_Homo sapiens_hsa00232	1.23092966
36	Galactose metabolism_Homo sapiens_hsa00052	1.21511250
37	Protein export_Homo sapiens_hsa03060	1.17966080
38	Purine metabolism_Homo sapiens_hsa00230	1.14626088
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.13375688
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.10858720
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.05505567
42	p53 signaling pathway_Homo sapiens_hsa04115	1.04079639
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.02262077
44	Lysine degradation_Homo sapiens_hsa00310	1.00323003
45	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.99237953
46	Sulfur relay system_Homo sapiens_hsa04122	0.98284933
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97477506
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.97063118
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.94937748
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90735133
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.89908610
52	Alcoholism_Homo sapiens_hsa05034	0.88792639
53	Peroxisome_Homo sapiens_hsa04146	0.84389314
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.83735612
55	Butanoate metabolism_Homo sapiens_hsa00650	0.75078608
56	Sulfur metabolism_Homo sapiens_hsa00920	0.74445692
57	Parkinsons disease_Homo sapiens_hsa05012	0.72309977
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71276368
59	Huntingtons disease_Homo sapiens_hsa05016	0.71196582
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71026510
61	Metabolic pathways_Homo sapiens_hsa01100	0.69194694
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66653477
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66329050
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65412758
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.64951281
66	Carbon metabolism_Homo sapiens_hsa01200	0.64101479
67	Thyroid cancer_Homo sapiens_hsa05216	0.61713060
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.61300880
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61293259
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60571900
71	Other glycan degradation_Homo sapiens_hsa00511	0.59720367
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58936159
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58384643
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.56819505
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.55544969
76	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.54970017
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52581798
78	Fatty acid degradation_Homo sapiens_hsa00071	0.51293851
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49118499
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.48752558
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46713748
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44999633
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.43467134
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.43266168
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41895958
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40600300
87	Retinol metabolism_Homo sapiens_hsa00830	0.40254873
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39773844
89	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38718601
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38589231
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38353040
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.38021310
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36567605
94	Pancreatic secretion_Homo sapiens_hsa04972	0.36340114
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.36287892
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36228956
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34663830
98	Alzheimers disease_Homo sapiens_hsa05010	0.31333533
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.31101097
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30861385

KRT8P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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