ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.73596791
2	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.28566893
3	DNA double-strand break processing (GO:0000729)	4.23407383
4	cullin deneddylation (GO:0010388)	4.19657252
5	coenzyme catabolic process (GO:0009109)	3.60721456
6	protein deneddylation (GO:0000338)	3.57136178
7	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.53409572
8	protein complex biogenesis (GO:0070271)	3.52190665
9	DNA deamination (GO:0045006)	3.50974703
10	growth hormone secretion (GO:0030252)	3.49148296
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.44573032
12	mannosylation (GO:0097502)	3.41775565
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.38214723
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.38214723
15	NADH dehydrogenase complex assembly (GO:0010257)	3.38214723
16	positive regulation of growth hormone secretion (GO:0060124)	3.33462768
17	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.22170150
18	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.21782676
19	rRNA modification (GO:0000154)	3.21177969
20	regulation of cellular amino acid metabolic process (GO:0006521)	3.20980032
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16860374
22	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.13772013
23	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.13772013
24	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.13269272
25	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.13269272
26	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.13269272
27	platelet dense granule organization (GO:0060155)	3.12078525
28	cytidine deamination (GO:0009972)	3.07743408
29	cytidine metabolic process (GO:0046087)	3.07743408
30	cytidine catabolic process (GO:0006216)	3.07743408
31	pyrimidine dimer repair (GO:0006290)	3.07222232
32	long term synaptic depression (GO:0060292)	3.04749496
33	xenobiotic catabolic process (GO:0042178)	3.02781274
34	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.01979612
35	deoxyribonucleotide catabolic process (GO:0009264)	3.00825609
36	regulation of cilium movement (GO:0003352)	3.00589338
37	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.00470853
38	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.00470853
39	purine deoxyribonucleotide catabolic process (GO:0009155)	2.98328941
40	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.97596186
41	aldehyde catabolic process (GO:0046185)	2.96170521
42	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.95612569
43	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.95240087
44	inositol phosphate catabolic process (GO:0071545)	2.93407145
45	cornea development in camera-type eye (GO:0061303)	2.84805060
46	negative regulation of ligase activity (GO:0051352)	2.84728156
47	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.84728156
48	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.82822527
49	deoxyribose phosphate catabolic process (GO:0046386)	2.79781967
50	DNA catabolic process, exonucleolytic (GO:0000738)	2.79646198
51	axoneme assembly (GO:0035082)	2.79572403
52	base-excision repair, AP site formation (GO:0006285)	2.78474953
53	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.78377568
54	lactate metabolic process (GO:0006089)	2.77364433
55	lung secretory cell differentiation (GO:0061140)	2.75700206
56	respiratory chain complex IV assembly (GO:0008535)	2.75664192
57	rRNA methylation (GO:0031167)	2.75384186
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.73353546
59	cellular ketone body metabolic process (GO:0046950)	2.73181405
60	tRNA aminoacylation for protein translation (GO:0006418)	2.73049540
61	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.71246787
62	otic vesicle formation (GO:0030916)	2.69841812
63	regulation of cofactor metabolic process (GO:0051193)	2.67211545
64	regulation of coenzyme metabolic process (GO:0051196)	2.67211545
65	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.66892408
66	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.66153441
67	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.65709123
68	GMP metabolic process (GO:0046037)	2.64099479
69	glutathione derivative biosynthetic process (GO:1901687)	2.63172831
70	glutathione derivative metabolic process (GO:1901685)	2.63172831
71	inositol phosphate dephosphorylation (GO:0046855)	2.59899391
72	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.59899391
73	tRNA aminoacylation (GO:0043039)	2.59494399
74	amino acid activation (GO:0043038)	2.59494399
75	positive regulation of ligase activity (GO:0051351)	2.59481206
76	ketone body metabolic process (GO:1902224)	2.58615698
77	negative regulation by host of viral transcription (GO:0043922)	2.55043851
78	synapsis (GO:0007129)	2.53146638
79	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.53146302
80	cytochrome complex assembly (GO:0017004)	2.52659818
81	nucleoside diphosphate catabolic process (GO:0009134)	2.52141729
82	glyoxylate metabolic process (GO:0046487)	2.50313516
83	purine deoxyribonucleotide metabolic process (GO:0009151)	2.49382411
84	negative regulation of telomere maintenance (GO:0032205)	2.48134558
85	tRNA metabolic process (GO:0006399)	2.47809589
86	pyrimidine nucleotide catabolic process (GO:0006244)	2.47612100
87	regulation of cholesterol esterification (GO:0010872)	2.46918558
88	positive regulation of cell cycle arrest (GO:0071158)	2.46457780
89	tRNA processing (GO:0008033)	2.46393451
90	deoxyribonucleotide metabolic process (GO:0009262)	2.46048232
91	transmission of nerve impulse (GO:0019226)	2.45647880
92	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.45610030
93	metallo-sulfur cluster assembly (GO:0031163)	2.45569000
94	iron-sulfur cluster assembly (GO:0016226)	2.45569000
95	dopamine transport (GO:0015872)	2.43854268
96	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.43594694
97	GPI anchor metabolic process (GO:0006505)	2.43381996
98	aspartate family amino acid catabolic process (GO:0009068)	2.43134549
99	DNA dealkylation (GO:0035510)	2.42056144
100	regulation of cellular amine metabolic process (GO:0033238)	2.41333765

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.89603791
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.74208006
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.47657765
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.79323726
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28800371
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.25568708
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99590915
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.94978057
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81413582
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.77131094
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.55792448
12	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.47830698
13	VDR_22108803_ChIP-Seq_LS180_Human	2.42960286
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30143666
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26169159
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.17229654
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15103168
18	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.10485191
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.05317167
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03654766
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.89932338
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.89666068
23	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.88548088
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.87314718
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.86650276
26	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.75712241
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72160221
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.65989611
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63149302
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.61828350
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.59468450
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.58519069
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58074598
34	FUS_26573619_Chip-Seq_HEK293_Human	1.56854113
35	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.46867706
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44859796
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.41989253
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.40430082
39	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.39461730
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.37097707
41	P300_19829295_ChIP-Seq_ESCs_Human	1.37062844
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.33927181
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.33132482
44	EWS_26573619_Chip-Seq_HEK293_Human	1.32521256
45	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.30965120
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29590252
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.29224958
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29224958
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26752579
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.23719184
51	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23446013
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17418139
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.16765849
54	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.15845727
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14520768
56	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.13006254
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12562139
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12451166
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.12193784
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11627289
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11355716
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10989983
63	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.10599825
64	PHF8_20622853_ChIP-Seq_HELA_Human	1.08718378
65	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05431130
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05315258
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05315258
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03861888
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.03759076
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03076835
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03030001
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.02911524
73	NCOR_22424771_ChIP-Seq_293T_Human	1.02827848
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01963723
75	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.01653567
76	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99246690
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99246690
78	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98958349
79	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.97620181
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95455166
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94743618
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.94718123
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94530689
84	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.94122699
85	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93944427
86	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.92554556
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92365501
88	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91563163
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90253782
90	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.89731692
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88686207
92	ETV1_20927104_ChIP-Seq_GIST48_Human	0.86552988
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.85822695
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.84736358
95	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.84733450
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.84609305
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.83428398
98	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.82685926
99	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.82610569
100	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.82161724

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.84619237
2	MP0000372_irregular_coat_pigmentation	3.45929361
3	MP0000516_abnormal_urinary_system	2.60195677
4	MP0005367_renal/urinary_system_phenotyp	2.60195677
5	MP0001984_abnormal_olfaction	2.53529939
6	MP0003786_premature_aging	2.52384037
7	MP0006035_abnormal_mitochondrial_morpho	2.34446391
8	MP0000015_abnormal_ear_pigmentation	2.32743759
9	MP0008058_abnormal_DNA_repair	2.16519677
10	MP0002254_reproductive_system_inflammat	2.14618126
11	MP0001968_abnormal_touch/_nociception	2.06431051
12	MP0008872_abnormal_physiological_respon	2.02859695
13	MP0003806_abnormal_nucleotide_metabolis	2.01610261
14	MP0005551_abnormal_eye_electrophysiolog	1.94064462
15	MP0005075_abnormal_melanosome_morpholog	1.89862521
16	MP0008789_abnormal_olfactory_epithelium	1.84896399
17	MP0002938_white_spotting	1.84247940
18	MP0001501_abnormal_sleep_pattern	1.75666589
19	MP0005408_hypopigmentation	1.72569801
20	MP0002102_abnormal_ear_morphology	1.70104515
21	MP0003718_maternal_effect	1.69711808
22	MP0003195_calcinosis	1.68848528
23	MP0001764_abnormal_homeostasis	1.68229183
24	MP0003186_abnormal_redox_activity	1.66795865
25	MP0008007_abnormal_cellular_replicative	1.64217239
26	MP0002736_abnormal_nociception_after	1.62288501
27	MP0008995_early_reproductive_senescence	1.62134351
28	MP0005646_abnormal_pituitary_gland	1.58207457
29	MP0005394_taste/olfaction_phenotype	1.58031485
30	MP0005499_abnormal_olfactory_system	1.58031485
31	MP0003011_delayed_dark_adaptation	1.56377234
32	MP0004147_increased_porphyrin_level	1.56334130
33	MP0003880_abnormal_central_pattern	1.54436013
34	MP0006276_abnormal_autonomic_nervous	1.53394314
35	MP0006292_abnormal_olfactory_placode	1.51277079
36	MP0002876_abnormal_thyroid_physiology	1.49829763
37	MP0002638_abnormal_pupillary_reflex	1.49641560
38	MP0002160_abnormal_reproductive_system	1.49581787
39	MP0008875_abnormal_xenobiotic_pharmacok	1.48458553
40	MP0005410_abnormal_fertilization	1.46482453
41	MP0005085_abnormal_gallbladder_physiolo	1.40746885
42	MP0003693_abnormal_embryo_hatching	1.40450161
43	MP0001929_abnormal_gametogenesis	1.39581377
44	MP0001986_abnormal_taste_sensitivity	1.39468362
45	MP0006036_abnormal_mitochondrial_physio	1.39299910
46	MP0001881_abnormal_mammary_gland	1.36124051
47	MP0010329_abnormal_lipoprotein_level	1.33442993
48	MP0003698_abnormal_male_reproductive	1.31554456
49	MP0005084_abnormal_gallbladder_morpholo	1.29290774
50	MP0006072_abnormal_retinal_apoptosis	1.28285870
51	MP0009697_abnormal_copulation	1.24948239
52	MP0001529_abnormal_vocalization	1.24880230
53	MP0002277_abnormal_respiratory_mucosa	1.23996157
54	MP0009780_abnormal_chondrocyte_physiolo	1.22905487
55	MP0001666_abnormal_nutrient_absorption	1.19787897
56	MP0002095_abnormal_skin_pigmentation	1.17428036
57	MP0000647_abnormal_sebaceous_gland	1.17003629
58	MP0006082_CNS_inflammation	1.14703604
59	MP0005171_absent_coat_pigmentation	1.14484964
60	MP0005174_abnormal_tail_pigmentation	1.12171913
61	MP0005365_abnormal_bile_salt	1.12000683
62	MP0005360_urolithiasis	1.08894796
63	MP0002909_abnormal_adrenal_gland	1.08411025
64	MP0005636_abnormal_mineral_homeostasis	1.06108702
65	MP0005253_abnormal_eye_physiology	1.05927559
66	MP0001119_abnormal_female_reproductive	1.05177551
67	MP0000631_abnormal_neuroendocrine_gland	1.04716087
68	MP0005389_reproductive_system_phenotype	1.03867362
69	MP0002210_abnormal_sex_determination	1.03227519
70	MP0005332_abnormal_amino_acid	1.02388170
71	MP0003787_abnormal_imprinting	1.00395012
72	MP0000653_abnormal_sex_gland	1.00305924
73	MP0004043_abnormal_pH_regulation	1.00283833
74	MP0010094_abnormal_chromosome_stability	0.97375378
75	MP0003567_abnormal_fetal_cardiomyocyte	0.96569429
76	MP0002229_neurodegeneration	0.94766399
77	MP0000358_abnormal_cell_content/	0.92530274
78	MP0001486_abnormal_startle_reflex	0.87927189
79	MP0005266_abnormal_metabolism	0.87510895
80	MP0001905_abnormal_dopamine_level	0.86158554
81	MP0004019_abnormal_vitamin_homeostasis	0.86054061
82	MP0003136_yellow_coat_color	0.85320656
83	MP0003183_abnormal_peptide_metabolism	0.83944724
84	MP0005670_abnormal_white_adipose	0.83405302
85	MP0000538_abnormal_urinary_bladder	0.83176323
86	MP0001145_abnormal_male_reproductive	0.80574726
87	MP0009046_muscle_twitch	0.80289540
88	MP0001324_abnormal_eye_pigmentation	0.77599821
89	MP0004957_abnormal_blastocyst_morpholog	0.75396844
90	MP0000678_abnormal_parathyroid_gland	0.74891986
91	MP0002751_abnormal_autonomic_nervous	0.72009048
92	MP0000427_abnormal_hair_cycle	0.70112628
93	MP0005395_other_phenotype	0.69576788
94	MP0003077_abnormal_cell_cycle	0.69404415
95	MP0008932_abnormal_embryonic_tissue	0.69334743
96	MP0004264_abnormal_extraembryonic_tissu	0.68742164
97	MP0000383_abnormal_hair_follicle	0.68561541
98	MP0002075_abnormal_coat/hair_pigmentati	0.67877964
99	MP0003252_abnormal_bile_duct	0.67336487
100	MP0002735_abnormal_chemical_nociception	0.66597066

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	3.41765735
2	Abnormality of glycolysis (HP:0004366)	3.40310219
3	Increased CSF lactate (HP:0002490)	3.35848369
4	Cholecystitis (HP:0001082)	3.29936406
5	Abnormal gallbladder physiology (HP:0012438)	3.29936406
6	Increased serum pyruvate (HP:0003542)	3.24491417
7	Acute encephalopathy (HP:0006846)	3.21596985
8	Acute necrotizing encephalopathy (HP:0006965)	3.21135651
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.12976626
10	Type I transferrin isoform profile (HP:0003642)	3.12827734
11	Cerebral hypomyelination (HP:0006808)	3.10428591
12	Hepatocellular necrosis (HP:0001404)	3.07760207
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.02959183
14	Abnormality of alanine metabolism (HP:0010916)	3.02959183
15	Hyperalaninemia (HP:0003348)	3.02959183
16	Mitochondrial inheritance (HP:0001427)	2.93024564
17	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.85978729
18	Abnormal protein N-linked glycosylation (HP:0012347)	2.85978729
19	Abnormal protein glycosylation (HP:0012346)	2.85978729
20	Abnormal glycosylation (HP:0012345)	2.85978729
21	Molar tooth sign on MRI (HP:0002419)	2.85867607
22	Abnormality of midbrain morphology (HP:0002418)	2.85867607
23	Progressive macrocephaly (HP:0004481)	2.75930397
24	Hepatic necrosis (HP:0002605)	2.70217855
25	Chronic hepatic failure (HP:0100626)	2.69487352
26	Progressive inability to walk (HP:0002505)	2.68722724
27	Sensory axonal neuropathy (HP:0003390)	2.68379275
28	Hyperglycinemia (HP:0002154)	2.57709258
29	True hermaphroditism (HP:0010459)	2.47959020
30	Abnormality of the renal cortex (HP:0011035)	2.44823620
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.42439457
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.42439457
33	Medial flaring of the eyebrow (HP:0010747)	2.40186844
34	Pancreatic cysts (HP:0001737)	2.39856628
35	Hyperglycinuria (HP:0003108)	2.38541672
36	Lactic acidosis (HP:0003128)	2.37372952
37	Abnormality of serum amino acid levels (HP:0003112)	2.36468841
38	Increased serum lactate (HP:0002151)	2.35714819
39	CNS hypomyelination (HP:0003429)	2.35549447
40	Nephrogenic diabetes insipidus (HP:0009806)	2.35135306
41	Abnormality of glycine metabolism (HP:0010895)	2.23659229
42	Abnormality of serine family amino acid metabolism (HP:0010894)	2.23659229
43	Pancreatic fibrosis (HP:0100732)	2.17719961
44	Cerebral edema (HP:0002181)	2.15173708
45	Hypoplasia of the fovea (HP:0007750)	2.14201878
46	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.14201878
47	Progressive microcephaly (HP:0000253)	2.11687750
48	Hypoproteinemia (HP:0003075)	2.11133333
49	Absent speech (HP:0001344)	2.06980348
50	Tubular atrophy (HP:0000092)	2.06717522
51	Congenital primary aphakia (HP:0007707)	2.06155597
52	Lethargy (HP:0001254)	2.03022353
53	Nephronophthisis (HP:0000090)	2.02900511
54	Abnormal drinking behavior (HP:0030082)	2.01488343
55	Polydipsia (HP:0001959)	2.01488343
56	Ragged-red muscle fibers (HP:0003200)	2.01481606
57	Poikiloderma (HP:0001029)	2.00752144
58	Ependymoma (HP:0002888)	1.98618084
59	Gait imbalance (HP:0002141)	1.98041569
60	Muscular hypotonia of the trunk (HP:0008936)	1.95736462
61	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.92278655
62	Abolished electroretinogram (ERG) (HP:0000550)	1.91512636
63	Cutaneous melanoma (HP:0012056)	1.91022023
64	Reduced antithrombin III activity (HP:0001976)	1.90872457
65	Abnormality of the fovea (HP:0000493)	1.89305663
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88719146
67	Emotional lability (HP:0000712)	1.88490933
68	Amyotrophic lateral sclerosis (HP:0007354)	1.87792850
69	Lipid accumulation in hepatocytes (HP:0006561)	1.87724652
70	Optic disc pallor (HP:0000543)	1.87556215
71	Neonatal respiratory distress (HP:0002643)	1.87298396
72	Abnormal albumin level (HP:0012116)	1.86507137
73	Hypoalbuminemia (HP:0003073)	1.86507137
74	CNS demyelination (HP:0007305)	1.85283603
75	Meckel diverticulum (HP:0002245)	1.84781927
76	Microvesicular hepatic steatosis (HP:0001414)	1.82313555
77	Hypothermia (HP:0002045)	1.81195302
78	Abnormality of the ileum (HP:0001549)	1.81172634
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80222414
80	Dicarboxylic aciduria (HP:0003215)	1.80222414
81	Bifid tongue (HP:0010297)	1.80084418
82	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.79081910
83	Genital tract atresia (HP:0001827)	1.78913702
84	Leukodystrophy (HP:0002415)	1.77675726
85	Increased hepatocellular lipid droplets (HP:0006565)	1.77007056
86	Methylmalonic acidemia (HP:0002912)	1.76122420
87	Retinal atrophy (HP:0001105)	1.75699420
88	Abnormality of the astrocytes (HP:0100707)	1.75201665
89	Astrocytoma (HP:0009592)	1.75201665
90	Renal cortical cysts (HP:0000803)	1.74409951
91	Vaginal atresia (HP:0000148)	1.74372925
92	Hypobetalipoproteinemia (HP:0003563)	1.73914705
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73816738
94	Hypoplastic pelvis (HP:0008839)	1.73304731
95	Delayed myelination (HP:0012448)	1.72264648
96	Short tibia (HP:0005736)	1.71842232
97	Glycosuria (HP:0003076)	1.71136352
98	Abnormality of urine glucose concentration (HP:0011016)	1.71136352
99	Retinitis pigmentosa (HP:0000510)	1.69862317
100	Chromsome breakage (HP:0040012)	1.69419223

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	3.95142763
2	WNK3	2.81045046
3	VRK2	2.79231777
4	TRIM28	2.66552901
5	KDR	2.64627586
6	TESK2	2.51484922
7	BUB1	2.46837032
8	EIF2AK1	2.41685092
9	BCR	2.38755581
10	FRK	2.37323538
11	EIF2AK3	2.22045788
12	PLK2	2.15751334
13	MAP3K12	2.09871072
14	VRK1	2.06092442
15	BCKDK	2.05142167
16	TESK1	2.03735724
17	ZAK	1.83992079
18	NUAK1	1.83833849
19	SRPK1	1.77169559
20	ERBB3	1.70067052
21	CDK19	1.66868384
22	BMPR1B	1.59353148
23	LIMK1	1.53735305
24	PNCK	1.51328416
25	MAP4K2	1.44020222
26	TNIK	1.43567254
27	MAPK13	1.34121056
28	FLT3	1.30300643
29	MAP3K4	1.29927120
30	PKN2	1.12206580
31	DAPK1	1.12091345
32	EPHA4	1.10581384
33	WEE1	1.10338866
34	CSNK1G3	1.04920637
35	CCNB1	1.02863947
36	PBK	1.01619763
37	OXSR1	1.00887637
38	EPHA3	0.99456689
39	CASK	0.97502535
40	RPS6KA4	0.96665218
41	PAK3	0.96605947
42	PLK3	0.96491156
43	ADRBK2	0.92992496
44	TSSK6	0.91813514
45	PRKCE	0.91495031
46	GRK1	0.91140928
47	PINK1	0.90360548
48	TLK1	0.89180348
49	EPHA2	0.89024682
50	INSRR	0.87266347
51	FER	0.87113495
52	PLK1	0.84317576
53	MAP2K7	0.81308878
54	FGFR1	0.80012365
55	CSNK1G1	0.76944223
56	EIF2AK2	0.76665562
57	DYRK2	0.76482734
58	PRKCI	0.76252925
59	STK39	0.75545851
60	CSNK1A1L	0.74131646
61	PTK2B	0.73980982
62	RPS6KA5	0.72880424
63	CSNK1G2	0.72751761
64	TXK	0.70162401
65	PLK4	0.67549600
66	MINK1	0.67088324
67	CAMKK2	0.65885671
68	AURKA	0.63133160
69	CSNK1A1	0.61686396
70	MARK1	0.61410531
71	ACVR1B	0.61305612
72	PRKCQ	0.59088869
73	PIM2	0.58969838
74	PRKCG	0.58939008
75	CDC7	0.58063236
76	ABL2	0.57007924
77	ATR	0.56868182
78	NEK1	0.55661813
79	MATK	0.53510220
80	MYLK	0.53112304
81	GRK5	0.53056053
82	NME1	0.51761757
83	WNK4	0.51651614
84	MST4	0.46230482
85	IKBKB	0.46114625
86	SIK3	0.42011582
87	CAMK2A	0.40377644
88	CSNK1D	0.39988719
89	AKT3	0.39439286
90	PRKACB	0.39233481
91	CSNK2A1	0.36647630
92	ADRBK1	0.34967374
93	CAMK2G	0.31965773
94	TNK2	0.31906797
95	DAPK3	0.31789366
96	PRKACA	0.31152628
97	ATM	0.31152401
98	MAP3K11	0.30933136
99	PRKCA	0.30878152
100	CSNK2A2	0.30188085

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.66726806
2	Protein export_Homo sapiens_hsa03060	3.01414690
3	Propanoate metabolism_Homo sapiens_hsa00640	2.48265066
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.46393720
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32237645
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.09054764
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05102404
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.01554718
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.97716469
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92675075
11	Parkinsons disease_Homo sapiens_hsa05012	1.91470002
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.91222784
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.89231809
14	Fatty acid elongation_Homo sapiens_hsa00062	1.85266417
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.79997711
16	Fat digestion and absorption_Homo sapiens_hsa04975	1.79439549
17	RNA polymerase_Homo sapiens_hsa03020	1.76995842
18	Peroxisome_Homo sapiens_hsa04146	1.75464946
19	Butanoate metabolism_Homo sapiens_hsa00650	1.71398159
20	Glutathione metabolism_Homo sapiens_hsa00480	1.62196866
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61172963
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.58809440
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.55872619
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55756277
25	Phototransduction_Homo sapiens_hsa04744	1.55567650
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.52779325
27	Carbon metabolism_Homo sapiens_hsa01200	1.47764673
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.42071548
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41630065
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.40170107
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.37665042
32	Pentose phosphate pathway_Homo sapiens_hsa00030	1.36256382
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34646563
34	Huntingtons disease_Homo sapiens_hsa05016	1.33760507
35	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.28779701
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28106986
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24845363
38	Base excision repair_Homo sapiens_hsa03410	1.22870091
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.21780195
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.21080942
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16496580
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.15861228
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14787337
44	Homologous recombination_Homo sapiens_hsa03440	1.12723733
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10645195
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.09942915
47	RNA transport_Homo sapiens_hsa03013	1.09707953
48	Basal transcription factors_Homo sapiens_hsa03022	1.09278481
49	Sulfur metabolism_Homo sapiens_hsa00920	1.07296727
50	Sulfur relay system_Homo sapiens_hsa04122	1.05804873
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.05794740
52	Caffeine metabolism_Homo sapiens_hsa00232	1.05020392
53	Fatty acid metabolism_Homo sapiens_hsa01212	1.03663723
54	RNA degradation_Homo sapiens_hsa03018	1.03409934
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01478772
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01415587
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99924602
58	Alzheimers disease_Homo sapiens_hsa05010	0.98698039
59	Purine metabolism_Homo sapiens_hsa00230	0.96720761
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.96251801
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95868887
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.95583327
63	Metabolic pathways_Homo sapiens_hsa01100	0.94894352
64	Retinol metabolism_Homo sapiens_hsa00830	0.93647409
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89888100
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.89142009
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88056475
68	Fatty acid degradation_Homo sapiens_hsa00071	0.87966462
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80347214
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.79387231
71	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.75950811
72	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75745910
73	One carbon pool by folate_Homo sapiens_hsa00670	0.72960499
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.70261012
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.69123667
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67918367
77	Vibrio cholerae infection_Homo sapiens_hsa05110	0.66484126
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64683293
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63902727
80	DNA replication_Homo sapiens_hsa03030	0.63214610
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61891623
82	Mismatch repair_Homo sapiens_hsa03430	0.60971501
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55922026
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54941840
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54395650
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51948032
87	Spliceosome_Homo sapiens_hsa03040	0.51169829
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49582849
89	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.48961381
90	Oocyte meiosis_Homo sapiens_hsa04114	0.47510280
91	Olfactory transduction_Homo sapiens_hsa04740	0.47090287
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46634083
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45867230
94	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45627873
95	Regulation of autophagy_Homo sapiens_hsa04140	0.45334814
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43885285
97	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40203295
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.39827062
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39665143
100	Alcoholism_Homo sapiens_hsa05034	0.39450674

KRT8P41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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