KRT8P42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of odontogenesis (GO:0042482)4.90014095
2homocysteine metabolic process (GO:0050667)4.69909949
3cellular response to epinephrine stimulus (GO:0071872)4.57426257
4regulation of relaxation of muscle (GO:1901077)4.52715321
5urea cycle (GO:0000050)4.46360196
6atrioventricular valve morphogenesis (GO:0003181)4.38186268
7midgut development (GO:0007494)4.23610050
8regulation of vitamin metabolic process (GO:0030656)4.09012562
9branching involved in labyrinthine layer morphogenesis (GO:0060670)4.08605626
10urea metabolic process (GO:0019627)3.95475634
11regulation of vitamin D biosynthetic process (GO:0060556)3.94210153
12positive regulation of heat generation (GO:0031652)3.93546275
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.93001509
14citrulline biosynthetic process (GO:0019240)3.84460642
15positive regulation of p38MAPK cascade (GO:1900745)3.78794623
16regulation of cardiac muscle cell contraction (GO:0086004)3.78379546
17response to peptidoglycan (GO:0032494)3.77997372
18regulation of interferon-beta biosynthetic process (GO:0045357)3.76214771
19T-helper 1 type immune response (GO:0042088)3.75445654
20neutrophil activation involved in immune response (GO:0002283)3.73125768
21germinal center formation (GO:0002467)3.73034780
22glycolipid catabolic process (GO:0019377)3.68885512
23regulation of fever generation (GO:0031620)3.68298267
24detection of molecule of bacterial origin (GO:0032490)3.63139782
25response to epinephrine (GO:0071871)3.59642947
26neutrophil chemotaxis (GO:0030593)3.57336286
27pyrimidine-containing compound transmembrane transport (GO:0072531)3.55831168
28negative regulation of complement activation (GO:0045916)3.49938941
29nitrogen cycle metabolic process (GO:0071941)3.48786020
30cAMP catabolic process (GO:0006198)3.48195705
31hepatocyte differentiation (GO:0070365)3.47686715
32neutrophil migration (GO:1990266)3.47244775
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37165118
34glycosphingolipid catabolic process (GO:0046479)3.34071025
35response to laminar fluid shear stress (GO:0034616)3.28820069
36cyclooxygenase pathway (GO:0019371)3.20320534
37regulation of T-helper 2 cell differentiation (GO:0045628)3.19133939
38low-density lipoprotein particle clearance (GO:0034383)3.18664232
39negative regulation of interleukin-12 production (GO:0032695)3.16711293
40cellular extravasation (GO:0045123)3.16409067
41cellular response to arsenic-containing substance (GO:0071243)3.15634379
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.15431751
43granulocyte activation (GO:0036230)3.15031829
44negative regulation of alcohol biosynthetic process (GO:1902931)3.14732351
45macrophage activation (GO:0042116)3.13978476
46positive regulation of NF-kappaB import into nucleus (GO:0042346)3.11392224
47negative regulation of protein activation cascade (GO:2000258)3.09379217
48positive regulation of osteoblast proliferation (GO:0033690)3.07242563
49granulocyte chemotaxis (GO:0071621)3.06665435
50citrulline metabolic process (GO:0000052)3.03800719
51regulation of interleukin-8 biosynthetic process (GO:0045414)3.03792332
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.00757484
53iron ion import (GO:0097286)2.99070731
54L-alpha-amino acid transmembrane transport (GO:1902475)2.97800821
55positive regulation of chemokine biosynthetic process (GO:0045080)2.97639633
56GDP-mannose metabolic process (GO:0019673)2.97231869
57amyloid precursor protein catabolic process (GO:0042987)2.93087064
58energy homeostasis (GO:0097009)2.91867527
59granulocyte migration (GO:0097530)2.91694846
60cyclic nucleotide catabolic process (GO:0009214)2.90931636
61macrophage activation involved in immune response (GO:0002281)2.90634107
62neutrophil activation (GO:0042119)2.89619918
63positive regulation of acute inflammatory response (GO:0002675)2.86207853
64oligosaccharide catabolic process (GO:0009313)2.83813551
65positive regulation of pseudopodium assembly (GO:0031274)2.83382792
66establishment of endothelial barrier (GO:0061028)2.82147265
67trophoblast giant cell differentiation (GO:0060707)2.81223857
68xenobiotic catabolic process (GO:0042178)2.80941845
69positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.80666520
70NIK/NF-kappaB signaling (GO:0038061)2.78542721
71regulation of glucocorticoid metabolic process (GO:0031943)2.75359799
72ER overload response (GO:0006983)2.74894017
73modulation by symbiont of host defense response (GO:0052031)2.74888080
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74888080
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74888080
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.74888080
77modulation by symbiont of host immune response (GO:0052553)2.74888080
78positive regulation by symbiont of host defense response (GO:0052509)2.74888080
79embryonic process involved in female pregnancy (GO:0060136)2.73533810
80negative regulation of humoral immune response (GO:0002921)2.72349045
81renal absorption (GO:0070293)2.71642158
82positive regulation of fatty acid biosynthetic process (GO:0045723)2.70589345
83membrane lipid catabolic process (GO:0046466)2.70063648
84positive regulation of nitric oxide biosynthetic process (GO:0045429)2.68791667
85prostanoid biosynthetic process (GO:0046457)2.68640463
86prostaglandin biosynthetic process (GO:0001516)2.68640463
87production of molecular mediator involved in inflammatory response (GO:0002532)2.67706491
88regulation of actin filament-based movement (GO:1903115)2.66584562
89positive regulation of astrocyte differentiation (GO:0048711)2.66548226
90regulation of heat generation (GO:0031650)2.66414221
91dicarboxylic acid biosynthetic process (GO:0043650)2.64750446
92negative regulation of B cell mediated immunity (GO:0002713)2.64637481
93negative regulation of immunoglobulin mediated immune response (GO:0002890)2.64637481
94immunoglobulin mediated immune response (GO:0016064)2.63846457
95regulation of chemokine biosynthetic process (GO:0045073)2.60240744
96neutrophil mediated immunity (GO:0002446)2.59570691
97basement membrane organization (GO:0071711)2.58162860
98antimicrobial humoral response (GO:0019730)2.56478356
99positive regulation of leukocyte apoptotic process (GO:2000108)2.55227018
100regulation of NF-kappaB import into nucleus (GO:0042345)2.54173798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.17771869
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.14194623
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96627824
4ZNF263_19887448_ChIP-Seq_K562_Human2.92173720
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38753999
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31542522
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.26314945
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26162249
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19210363
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18001066
11VDR_21846776_ChIP-Seq_THP-1_Human2.15270138
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.03994964
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.01561024
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00439119
15EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84310389
16STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84003537
17E2F7_22180533_ChIP-Seq_HELA_Human1.82030963
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80076982
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76010646
20RACK7_27058665_Chip-Seq_MCF-7_Human1.75706274
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73265990
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.72068172
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71302757
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70590522
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.67167321
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62137322
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59833669
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56037919
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53981080
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53866828
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53312901
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.52646861
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52305301
34VDR_24763502_ChIP-Seq_THP-1_Human1.51717961
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.48258161
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47184520
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46042137
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44869617
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.43866924
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43467679
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41511783
42ATF3_27146783_Chip-Seq_COLON_Human1.39560318
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39412891
44LXR_22292898_ChIP-Seq_THP-1_Human1.37987028
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34645890
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33653319
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31839415
48CLOCK_20551151_ChIP-Seq_293T_Human1.31771649
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29681814
50MAF_26560356_Chip-Seq_TH1_Human1.28798971
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27966763
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.27330746
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27085541
54MYC_22102868_ChIP-Seq_BL_Human1.27008007
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26797439
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26639929
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23662951
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.23033310
59TFEB_21752829_ChIP-Seq_HELA_Human1.21925924
60XRN2_22483619_ChIP-Seq_HELA_Human1.20025042
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.19962803
62SPI1_23547873_ChIP-Seq_NB4_Human1.18562585
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17917506
64DCP1A_22483619_ChIP-Seq_HELA_Human1.17565725
65GATA6_25053715_ChIP-Seq_YYC3_Human1.17445737
66BCOR_27268052_Chip-Seq_Bcells_Human1.15695378
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15572526
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.13369950
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11547257
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11176725
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10907910
72TCF7_22412390_ChIP-Seq_EML_Mouse1.08380841
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08061811
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.05786801
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05198899
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04907607
77GATA1_22025678_ChIP-Seq_K562_Human1.04699957
78UTX_26944678_Chip-Seq_JUKART_Human1.04420059
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04416314
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04347949
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04325390
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04183025
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02413900
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02378242
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02352570
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01613854
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00890547
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00405971
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00276556
90MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99857335
91CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99322601
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99203878
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99116479
94LXR_22158963_ChIP-Seq_LIVER_Mouse0.98873140
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98257476
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98257476
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97844485
98FOXM1_23109430_ChIP-Seq_U2OS_Human0.96571000
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.95605499
100KDM2B_26808549_Chip-Seq_DND41_Human0.95505007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.88950772
2MP0003724_increased_susceptibility_to4.77199136
3MP0005083_abnormal_biliary_tract4.01857618
4MP0008004_abnormal_stomach_pH3.91872190
5MP0005451_abnormal_body_composition3.47791773
6MP0009840_abnormal_foam_cell2.91437512
7MP0009278_abnormal_bone_marrow2.83324292
8MP0002139_abnormal_hepatobiliary_system2.70052838
9MP0003436_decreased_susceptibility_to2.61288215
10MP0005058_abnormal_lysosome_morphology2.57653729
11MP0010352_gastrointestinal_tract_polyps2.36712507
12MP0009764_decreased_sensitivity_to2.11410578
13MP0005085_abnormal_gallbladder_physiolo2.10638193
14MP0010234_abnormal_vibrissa_follicle2.04374982
15MP0003075_altered_response_to2.03069610
16MP0005360_urolithiasis1.93689307
17MP0006082_CNS_inflammation1.93595905
18MP0002148_abnormal_hypersensitivity_rea1.90136249
19MP0002419_abnormal_innate_immunity1.88844506
20MP0008260_abnormal_autophagy1.86096704
21MP0003806_abnormal_nucleotide_metabolis1.70143833
22MP0005076_abnormal_cell_differentiation1.64080252
23MP0001533_abnormal_skeleton_physiology1.63544383
24MP0001835_abnormal_antigen_presentation1.55920600
25MP0009785_altered_susceptibility_to1.54445836
26MP0008875_abnormal_xenobiotic_pharmacok1.53960280
27MP0004233_abnormal_muscle_weight1.52953181
28MP0005166_decreased_susceptibility_to1.51957690
29MP0005000_abnormal_immune_tolerance1.50375955
30MP0010155_abnormal_intestine_physiology1.45876036
31MP0005319_abnormal_enzyme/_coenzyme1.43330833
32MP0001853_heart_inflammation1.43242330
33MP0001545_abnormal_hematopoietic_system1.42470500
34MP0005397_hematopoietic_system_phenotyp1.42470500
35MP0005167_abnormal_blood-brain_barrier1.41666310
36MP0005025_abnormal_response_to1.39912198
37MP0005365_abnormal_bile_salt1.36959110
38MP0003453_abnormal_keratinocyte_physiol1.34870384
39MP0008469_abnormal_protein_level1.34322848
40MP0002723_abnormal_immune_serum1.30548315
41MP0004947_skin_inflammation1.30270740
42MP0003693_abnormal_embryo_hatching1.28659258
43MP0006054_spinal_hemorrhage1.26687947
44MP0000490_abnormal_crypts_of1.25067503
45MP0001764_abnormal_homeostasis1.24773264
46MP0004808_abnormal_hematopoietic_stem1.24086878
47MP0003191_abnormal_cellular_cholesterol1.23276782
48MP0001845_abnormal_inflammatory_respons1.22202821
49MP0009333_abnormal_splenocyte_physiolog1.20207349
50MP0002332_abnormal_exercise_endurance1.16776325
51MP0002452_abnormal_antigen_presenting1.15953940
52MP0000609_abnormal_liver_physiology1.11616047
53MP0004510_myositis1.10616173
54MP0001800_abnormal_humoral_immune1.08111552
55MP0002132_abnormal_respiratory_system1.06719573
56MP0004019_abnormal_vitamin_homeostasis1.04672938
57MP0000465_gastrointestinal_hemorrhage1.00314832
58MP0001790_abnormal_immune_system0.98936774
59MP0005387_immune_system_phenotype0.98936774
60MP0001666_abnormal_nutrient_absorption0.98495426
61MP0003828_pulmonary_edema0.98103748
62MP0005671_abnormal_response_to0.98086828
63MP0000858_altered_metastatic_potential0.94245695
64MP0000343_altered_response_to0.94237725
65MP0001819_abnormal_immune_cell0.93226981
66MP0002420_abnormal_adaptive_immunity0.93018465
67MP0000003_abnormal_adipose_tissue0.92741379
68MP0003448_altered_tumor_morphology0.92562146
69MP0004957_abnormal_blastocyst_morpholog0.91662231
70MP0005584_abnormal_enzyme/coenzyme_acti0.90728277
71MP0002877_abnormal_melanocyte_morpholog0.90306316
72MP0005375_adipose_tissue_phenotype0.90237786
73MP0002405_respiratory_system_inflammati0.87436575
74MP0005334_abnormal_fat_pad0.86647633
75MP0005248_abnormal_Harderian_gland0.85588404
76MP0002796_impaired_skin_barrier0.84270971
77MP0000685_abnormal_immune_system0.83452718
78MP0005464_abnormal_platelet_physiology0.79338492
79MP0002998_abnormal_bone_remodeling0.78579068
80MP0001849_ear_inflammation0.77684472
81MP0005332_abnormal_amino_acid0.75053738
82MP0005164_abnormal_response_to0.73693230
83MP0005666_abnormal_adipose_tissue0.73538480
84MP0001663_abnormal_digestive_system0.70917678
85MP0000604_amyloidosis0.69260800
86MP0000750_abnormal_muscle_regeneration0.67340328
87MP0009643_abnormal_urine_homeostasis0.67133931
88MP0009765_abnormal_xenobiotic_induced0.66345279
89MP0009763_increased_sensitivity_to0.64324386
90MP0001216_abnormal_epidermal_layer0.64209235
91MP0000716_abnormal_immune_system0.63783690
92MP0000598_abnormal_liver_morphology0.63268435
93MP0003879_abnormal_hair_cell0.63258365
94MP0005165_increased_susceptibility_to0.62006340
95MP0002118_abnormal_lipid_homeostasis0.61706036
96MP0002089_abnormal_postnatal_growth/wei0.61338911
97MP0002429_abnormal_blood_cell0.60839259
98MP0003795_abnormal_bone_structure0.60728854
99MP0001727_abnormal_embryo_implantation0.59580411
100MP0005376_homeostasis/metabolism_phenot0.58740142

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.69856629
2Abnormality of glycolipid metabolism (HP:0010969)4.51117921
3Abnormality of liposaccharide metabolism (HP:0010968)4.51117921
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.51117921
5Malnutrition (HP:0004395)4.03492445
6Orchitis (HP:0100796)3.94644161
7Vacuolated lymphocytes (HP:0001922)3.78105005
8Vascular calcification (HP:0004934)3.75900855
9Increased cerebral lipofuscin (HP:0011813)3.46503304
10Abnormality of macrophages (HP:0004311)3.45361151
11Optic neuritis (HP:0100653)3.37774674
12Retrobulbar optic neuritis (HP:0100654)3.37774674
13Myositis (HP:0100614)3.18707659
14Cardiovascular calcification (HP:0011915)3.14694349
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.09619606
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.05176411
17Ragged-red muscle fibers (HP:0003200)2.99666164
18Alkalosis (HP:0001948)2.98864108
19Abnormality of the nasal septum (HP:0000419)2.93148642
20Loss of speech (HP:0002371)2.90333684
21Nausea (HP:0002018)2.88333725
22Recurrent bacterial skin infections (HP:0005406)2.85840243
23Abnormality of pyrimidine metabolism (HP:0004353)2.83717958
24Micronodular cirrhosis (HP:0001413)2.80428079
25Retinal atrophy (HP:0001105)2.79448750
26Microvesicular hepatic steatosis (HP:0001414)2.78643881
27Recurrent abscess formation (HP:0002722)2.77232105
28Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75183529
29Abnormality of polysaccharide metabolism (HP:0011012)2.75183529
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75183529
31Hyperammonemia (HP:0001987)2.66364623
32Progressive muscle weakness (HP:0003323)2.58191339
33Systemic lupus erythematosus (HP:0002725)2.58066973
34Increased serum ferritin (HP:0003281)2.51003225
35Amyloidosis (HP:0011034)2.48575885
36Mucopolysacchariduria (HP:0008155)2.45945909
37Urinary glycosaminoglycan excretion (HP:0003541)2.45945909
38Vertebral compression fractures (HP:0002953)2.44140351
39Dysostosis multiplex (HP:0000943)2.40303800
40Hypobetalipoproteinemia (HP:0003563)2.39628538
41Eczematoid dermatitis (HP:0000976)2.33384358
42Subacute progressive viral hepatitis (HP:0006572)2.31798356
43Sparse lateral eyebrow (HP:0005338)2.30597454
44Tetany (HP:0001281)2.29634747
45Stomatitis (HP:0010280)2.29305441
46Paralysis (HP:0003470)2.21820065
47Abnormality of the periventricular white matter (HP:0002518)2.21411738
48Myocardial infarction (HP:0001658)2.20329183
49Hepatocellular carcinoma (HP:0001402)2.18866281
50Episodic fever (HP:0001954)2.18645125
51Pathologic fracture (HP:0002756)2.17798333
52Petechiae (HP:0000967)2.15587836
53Rough bone trabeculation (HP:0100670)2.15569932
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13030658
55Anorexia (HP:0002039)2.11599971
56Abnormal trabecular bone morphology (HP:0100671)2.11450051
57Progressive neurologic deterioration (HP:0002344)2.10334375
58Keratoconjunctivitis sicca (HP:0001097)2.08309004
59Elbow flexion contracture (HP:0002987)2.07878635
60Nuclear cataract (HP:0100018)2.07028195
61Xanthomatosis (HP:0000991)2.05890459
62Increased circulating renin level (HP:0000848)2.04714599
63Elevated erythrocyte sedimentation rate (HP:0003565)2.02593190
64Prolonged neonatal jaundice (HP:0006579)2.02295185
65Steatorrhea (HP:0002570)2.01070497
66Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99585126
67Mediastinal lymphadenopathy (HP:0100721)1.96822103
68Abnormality of alanine metabolism (HP:0010916)1.92985928
69Hyperalaninemia (HP:0003348)1.92985928
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92985928
71Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.91886958
72Gangrene (HP:0100758)1.89834791
73Abnormality of alkaline phosphatase activity (HP:0004379)1.88757035
74Abnormality of the distal phalanges of the toes (HP:0010182)1.87784990
75Fat malabsorption (HP:0002630)1.84708905
76Hemorrhage of the eye (HP:0011885)1.84486673
77Abnormality of the peritoneum (HP:0002585)1.82702215
78Stroke (HP:0001297)1.82543792
79Abnormal enzyme/coenzyme activity (HP:0012379)1.81866739
80Segmental peripheral demyelination/remyelination (HP:0003481)1.81184012
81Autoimmune thrombocytopenia (HP:0001973)1.81025398
82Paraparesis (HP:0002385)1.80514932
83Renal tubular acidosis (HP:0001947)1.80470714
84Keratoconjunctivitis (HP:0001096)1.78994158
85Mitral stenosis (HP:0001718)1.78766566
86Hepatosplenomegaly (HP:0001433)1.77952622
87Abnormality of iron homeostasis (HP:0011031)1.77721055
88Elevated alkaline phosphatase (HP:0003155)1.76629629
89Hypolipoproteinemia (HP:0010981)1.74697559
90Tetraparesis (HP:0002273)1.73405062
91Acute hepatic failure (HP:0006554)1.72080550
92Ureteral duplication (HP:0000073)1.71930374
93Purpura (HP:0000979)1.71898692
94Deformed sella turcica (HP:0002681)1.71881212
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71212246
96Irritability (HP:0000737)1.70702946
97Abnormality of the costochondral junction (HP:0000919)1.68683316
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68043301
99Abnormality of the Achilles tendon (HP:0005109)1.67718447
100Parakeratosis (HP:0001036)1.67655221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK29.08489854
2TLK13.65086339
3IRAK33.22617573
4ZAK2.93437820
5ERN12.77245035
6NME22.61067598
7PIM22.57882398
8PBK2.23919259
9SMG12.03376690
10MST1R1.99690675
11STK391.99588229
12WNK41.85571940
13BLK1.84726411
14ACVR1B1.84028340
15OXSR11.78836288
16STK161.74798956
17EPHA21.66489678
18NEK61.66162948
19MAP3K31.66074530
20ICK1.63109794
21TAOK21.56211128
22TESK21.54879393
23IRAK41.40068659
24MAP3K141.37434384
25MAP3K111.36374601
26TBK11.29562752
27TAOK11.21914409
28PAK41.21889483
29MAP3K11.14720301
30MAP2K31.12032396
31IRAK21.09613568
32IKBKB1.08941149
33BMPR21.05006286
34BUB11.01814079
35PIM11.01309660
36RPS6KA50.98622013
37RIPK10.92853783
38MAP2K20.92157865
39MAP4K10.92147168
40PDPK10.86206000
41MATK0.85606894
42LATS20.85594130
43RPS6KB20.81399636
44RAF10.78862999
45ABL20.78647525
46ZAP700.77357942
47TXK0.76655407
48SIK10.76234447
49IRAK10.74139578
50IKBKE0.70673471
51JAK20.70071722
52CSK0.68957388
53CHUK0.68300412
54RIPK40.66512880
55MAPK120.66186179
56TYK20.66016626
57AURKA0.65832757
58MAPK70.63949811
59MAPK110.62999961
60CCNB10.59232613
61PTK60.58407712
62CDK120.57528487
63TGFBR20.54724514
64AKT30.52798758
65GSK3A0.52736512
66DDR20.52381658
67MAP3K120.52024294
68CDK60.51513870
69DAPK30.51444323
70PDK10.49907272
71EPHB10.47879964
72FGFR40.47539528
73PRPF4B0.43335677
74GRK70.43220594
75AKT20.43125241
76STK100.42517647
77MAP3K80.42367868
78SRPK10.41411952
79GRK60.39901269
80PRKG20.37830736
81VRK10.37277238
82CDK90.37198498
83JAK30.37020986
84MTOR0.35580013
85CAMK1D0.34754862
86FER0.33242015
87MELK0.33002820
88NME10.32241156
89MET0.29793082
90CSNK1G30.29503554
91PAK10.28641728
92CAMK40.27825183
93CSNK1A1L0.27667135
94RPS6KA10.27088311
95AURKB0.27043082
96TESK10.23577210
97SIK30.23533961
98CAMK2G0.23178086
99MAP3K50.22949620
100STK110.22389173

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.96777575
2Arginine biosynthesis_Homo sapiens_hsa002203.21951722
3Other glycan degradation_Homo sapiens_hsa005112.97347786
4Sulfur relay system_Homo sapiens_hsa041222.52113369
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.38397839
6Alcoholism_Homo sapiens_hsa050342.29924037
7Legionellosis_Homo sapiens_hsa051342.27276101
8Vitamin digestion and absorption_Homo sapiens_hsa049772.13795088
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.08846999
10Fructose and mannose metabolism_Homo sapiens_hsa000512.07863964
11Lysosome_Homo sapiens_hsa041422.03928191
12Osteoclast differentiation_Homo sapiens_hsa043802.03511355
13Nitrogen metabolism_Homo sapiens_hsa009102.00661629
14TNF signaling pathway_Homo sapiens_hsa046681.95007372
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85030803
16Sulfur metabolism_Homo sapiens_hsa009201.78547035
17Leishmaniasis_Homo sapiens_hsa051401.76877201
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75966009
19Staphylococcus aureus infection_Homo sapiens_hsa051501.72532623
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63804413
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60660421
22Fatty acid biosynthesis_Homo sapiens_hsa000611.60652410
23Pertussis_Homo sapiens_hsa051331.59798663
24Biosynthesis of amino acids_Homo sapiens_hsa012301.56502875
25Folate biosynthesis_Homo sapiens_hsa007901.54993916
26Pentose phosphate pathway_Homo sapiens_hsa000301.51294197
27Galactose metabolism_Homo sapiens_hsa000521.49186699
28Viral carcinogenesis_Homo sapiens_hsa052031.48653345
29Bladder cancer_Homo sapiens_hsa052191.41237680
30Fat digestion and absorption_Homo sapiens_hsa049751.40022269
31Rheumatoid arthritis_Homo sapiens_hsa053231.36876834
32Malaria_Homo sapiens_hsa051441.35912859
33Tuberculosis_Homo sapiens_hsa051521.35234776
34Influenza A_Homo sapiens_hsa051641.33039017
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30076278
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.29272341
37Salmonella infection_Homo sapiens_hsa051321.26840794
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25789261
39Hepatitis C_Homo sapiens_hsa051601.22882550
40Glutathione metabolism_Homo sapiens_hsa004801.22169361
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05341915
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.99822093
43Toxoplasmosis_Homo sapiens_hsa051450.97623208
44Complement and coagulation cascades_Homo sapiens_hsa046100.95450933
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93387897
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90563810
47Carbon metabolism_Homo sapiens_hsa012000.88639593
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87063119
49DNA replication_Homo sapiens_hsa030300.84019381
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.83679810
51PPAR signaling pathway_Homo sapiens_hsa033200.81666986
52Herpes simplex infection_Homo sapiens_hsa051680.81582190
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80663131
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78257382
55Mineral absorption_Homo sapiens_hsa049780.77155687
56African trypanosomiasis_Homo sapiens_hsa051430.75741411
57Fatty acid degradation_Homo sapiens_hsa000710.74105908
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72420819
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70963765
60Sphingolipid metabolism_Homo sapiens_hsa006000.68612079
61Hepatitis B_Homo sapiens_hsa051610.68034740
62Renin-angiotensin system_Homo sapiens_hsa046140.67991852
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66508308
64Fatty acid metabolism_Homo sapiens_hsa012120.66098482
65Phenylalanine metabolism_Homo sapiens_hsa003600.65339598
66Apoptosis_Homo sapiens_hsa042100.64910614
67Amoebiasis_Homo sapiens_hsa051460.61915178
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61838854
69Phagosome_Homo sapiens_hsa041450.56457982
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56075589
71Prion diseases_Homo sapiens_hsa050200.55308644
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.55195385
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54194839
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.52261177
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49563305
76Hematopoietic cell lineage_Homo sapiens_hsa046400.48329857
77Graft-versus-host disease_Homo sapiens_hsa053320.46266119
78Ovarian steroidogenesis_Homo sapiens_hsa049130.45479309
79Small cell lung cancer_Homo sapiens_hsa052220.43288345
80Chemical carcinogenesis_Homo sapiens_hsa052040.42455492
81Asthma_Homo sapiens_hsa053100.41534479
82Shigellosis_Homo sapiens_hsa051310.40999879
83Histidine metabolism_Homo sapiens_hsa003400.39980083
84Acute myeloid leukemia_Homo sapiens_hsa052210.39915983
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38201056
86Glycerolipid metabolism_Homo sapiens_hsa005610.38179552
87Bile secretion_Homo sapiens_hsa049760.37423935
88Vibrio cholerae infection_Homo sapiens_hsa051100.37240045
89N-Glycan biosynthesis_Homo sapiens_hsa005100.36925156
90Protein digestion and absorption_Homo sapiens_hsa049740.36690688
91Pyrimidine metabolism_Homo sapiens_hsa002400.36584879
92TGF-beta signaling pathway_Homo sapiens_hsa043500.36461088
93Proteasome_Homo sapiens_hsa030500.36382252
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36054797
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35968516
96Tryptophan metabolism_Homo sapiens_hsa003800.35654334
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34184449
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.33548126
99Allograft rejection_Homo sapiens_hsa053300.32272824
100Thyroid cancer_Homo sapiens_hsa052160.32254440

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