ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurotransmitter-gated ion channel clustering (GO:0072578)	6.89830933
2	protein maturation by protein folding (GO:0022417)	6.33824884
3	synapsis (GO:0007129)	6.21725178
4	regulation of sarcomere organization (GO:0060297)	5.96386507
5	chromosome organization involved in meiosis (GO:0070192)	5.90347148
6	synaptonemal complex assembly (GO:0007130)	5.81721187
7	male meiosis I (GO:0007141)	5.60261963
8	synaptonemal complex organization (GO:0070193)	5.25495269
9	proteasome assembly (GO:0043248)	5.15990549
10	microtubule depolymerization (GO:0007019)	5.09574844
11	morphogenesis of an endothelium (GO:0003159)	4.95154676
12	endothelial tube morphogenesis (GO:0061154)	4.95154676
13	meiosis I (GO:0007127)	4.94309945
14	polyketide metabolic process (GO:0030638)	4.90842572
15	doxorubicin metabolic process (GO:0044598)	4.90842572
16	daunorubicin metabolic process (GO:0044597)	4.90842572
17	keratinocyte development (GO:0003334)	4.40369950
18	resolution of meiotic recombination intermediates (GO:0000712)	4.37113359
19	aminoglycoside antibiotic metabolic process (GO:0030647)	4.31369206
20	xenobiotic catabolic process (GO:0042178)	4.28047357
21	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.26589519
22	artery smooth muscle contraction (GO:0014824)	4.25546085
23	positive regulation of receptor biosynthetic process (GO:0010870)	4.23905733
24	piRNA metabolic process (GO:0034587)	4.13199091
25	DNA synthesis involved in DNA repair (GO:0000731)	4.08817572
26	meiotic nuclear division (GO:0007126)	3.93436495
27	heart field specification (GO:0003128)	3.89199133
28	secondary heart field specification (GO:0003139)	3.89199133
29	adaptation of signaling pathway (GO:0023058)	3.81503831
30	male meiosis (GO:0007140)	3.74285044
31	protein heterotetramerization (GO:0051290)	3.70446881
32	meiotic cell cycle process (GO:1903046)	3.65497250
33	DNA unwinding involved in DNA replication (GO:0006268)	3.65009591
34	lung secretory cell differentiation (GO:0061140)	3.64013241
35	macroautophagy (GO:0016236)	3.62231663
36	desmosome organization (GO:0002934)	3.52971257
37	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.46911940
38	tonic smooth muscle contraction (GO:0014820)	3.43191706
39	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.43167140
40	prostanoid biosynthetic process (GO:0046457)	3.32607732
41	prostaglandin biosynthetic process (GO:0001516)	3.32607732
42	negative regulation of stem cell proliferation (GO:2000647)	3.31005410
43	GDP-mannose metabolic process (GO:0019673)	3.24048757
44	sialylation (GO:0097503)	3.21371229
45	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.20445924
46	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.20248212
47	L-phenylalanine metabolic process (GO:0006558)	3.20248212
48	cobalamin metabolic process (GO:0009235)	3.17771555
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.17758639
50	tRNA methylation (GO:0030488)	3.14167567
51	DNA replication-dependent nucleosome organization (GO:0034723)	3.12447743
52	DNA replication-dependent nucleosome assembly (GO:0006335)	3.12447743
53	sister chromatid cohesion (GO:0007062)	3.07909749
54	regulation of cellular amino acid metabolic process (GO:0006521)	3.07405711
55	regulation of mitochondrial translation (GO:0070129)	3.06524555
56	galactose catabolic process (GO:0019388)	3.05033967
57	reciprocal meiotic recombination (GO:0007131)	3.02532622
58	reciprocal DNA recombination (GO:0035825)	3.02532622
59	energy homeostasis (GO:0097009)	3.02216086
60	negative regulation of ligase activity (GO:0051352)	2.99711369
61	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.99711369
62	barbed-end actin filament capping (GO:0051016)	2.99409100
63	glycoside metabolic process (GO:0016137)	2.93213998
64	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.90903315
65	inositol phosphate-mediated signaling (GO:0048016)	2.84345220
66	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83233254
67	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.83189104
68	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.82250790
69	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.82221453
70	mitotic sister chromatid cohesion (GO:0007064)	2.80177263
71	protein depolymerization (GO:0051261)	2.77505020
72	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.74897922
73	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.74897922
74	positive regulation of protein sumoylation (GO:0033235)	2.74401267
75	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.73432984
76	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.73432984
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.73432984
78	nucleotide transmembrane transport (GO:1901679)	2.72038325
79	positive regulation of actin filament depolymerization (GO:0030836)	2.71855966
80	positive regulation of ligase activity (GO:0051351)	2.71629315
81	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71403700
82	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71403700
83	nucleoside transmembrane transport (GO:1901642)	2.70673097
84	guanosine-containing compound biosynthetic process (GO:1901070)	2.68928565
85	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68280593
86	microtubule polymerization or depolymerization (GO:0031109)	2.65199582
87	galactose metabolic process (GO:0006012)	2.59835156
88	DNA replication checkpoint (GO:0000076)	2.59718875
89	histone H4 deacetylation (GO:0070933)	2.58192771
90	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.57762110
91	C-terminal protein lipidation (GO:0006501)	2.55121897
92	interferon-gamma secretion (GO:0072643)	2.53660170
93	prostanoid metabolic process (GO:0006692)	2.53394517
94	prostaglandin metabolic process (GO:0006693)	2.53394517
95	myoblast migration (GO:0051451)	2.52287122
96	regulation of gonadotropin secretion (GO:0032276)	2.52039408
97	mitochondrion degradation (GO:0000422)	2.52026794
98	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.51276353
99	vascular smooth muscle contraction (GO:0014829)	2.50125042
100	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.49910306

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.78680592
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.63022789
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.23919996
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.05669115
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.89115878
6	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.88948114
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59496703
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.56370543
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.47952892
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35756571
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.34611890
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.28464389
13	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.21139521
14	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.18793780
15	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.17099869
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.11835110
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.11705498
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.08152612
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	10.9237041
20	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.98692006
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94971205
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94857988
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.92143040
24	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.91664987
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.91278996
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.90111709
27	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.87224604
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.87097327
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.85275385
30	GATA1_22025678_ChIP-Seq_K562_Human	1.84727700
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.80602014
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.73818808
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.70468196
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.69695528
35	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.69215028
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.68973013
37	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.62267768
38	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.57864170
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56720797
40	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.50990245
41	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.46492374
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43685581
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.43338381
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.42519488
45	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.37239565
46	GATA4_25053715_ChIP-Seq_YYC3_Human	1.36991103
47	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.33748430
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.31818845
49	HTT_18923047_ChIP-ChIP_STHdh_Human	1.31751316
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30111559
51	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.29612879
52	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.28336420
53	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26073145
54	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.24549112
55	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.24453409
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.23325298
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.21652944
58	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17651324
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16825671
60	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.14570455
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.14232602
62	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.12436717
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10974549
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10604806
65	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.10290116
66	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.10290116
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09062538
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.03603349
69	BCOR_27268052_Chip-Seq_Bcells_Human	1.00456583
70	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98671315
71	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97032236
72	PHF8_20622854_ChIP-Seq_HELA_Human	0.96762608
73	ZNF274_21170338_ChIP-Seq_K562_Hela	0.94611803
74	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.93876605
75	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.93081544
76	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92443254
77	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89232140
78	BCL6_27268052_Chip-Seq_Bcells_Human	0.89163499
79	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.85816009
80	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.85183144
81	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.85033236
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.84545309
83	GATA6_25053715_ChIP-Seq_YYC3_Human	0.84056190
84	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.83737086
85	ATF3_27146783_Chip-Seq_COLON_Human	0.82875921
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.81119589
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.80782078
88	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.80736405
89	TTF2_22483619_ChIP-Seq_HELA_Human	0.78367493
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.76909287
91	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.76053354
92	EOMES_21245162_ChIP-Seq_HESCs_Human	0.74999942
93	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.74515236
94	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.73380661
95	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.73006536
96	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.72852105
97	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.72346690
98	SPI1_20517297_ChIP-Seq_HL60_Human	0.72196113
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.72189734
100	VDR_22108803_ChIP-Seq_LS180_Human	0.71807781

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.44138522
2	MP0003806_abnormal_nucleotide_metabolis	4.69927762
3	MP0008875_abnormal_xenobiotic_pharmacok	3.24645564
4	MP0000516_abnormal_urinary_system	3.00889434
5	MP0005367_renal/urinary_system_phenotyp	3.00889434
6	MP0008260_abnormal_autophagy	2.97461663
7	MP0002139_abnormal_hepatobiliary_system	2.32361894
8	MP0008058_abnormal_DNA_repair	2.24850802
9	MP0002132_abnormal_respiratory_system	2.22937231
10	MP0008877_abnormal_DNA_methylation	2.18943364
11	MP0005365_abnormal_bile_salt	2.15647270
12	MP0002796_impaired_skin_barrier	2.04619697
13	MP0002277_abnormal_respiratory_mucosa	2.01083451
14	MP0000537_abnormal_urethra_morphology	2.00416642
15	MP0002210_abnormal_sex_determination	1.99610821
16	MP0005084_abnormal_gallbladder_morpholo	1.98454885
17	MP0003786_premature_aging	1.92211970
18	MP0009780_abnormal_chondrocyte_physiolo	1.88580744
19	MP0004043_abnormal_pH_regulation	1.85357201
20	MP0001529_abnormal_vocalization	1.83350240
21	MP0002736_abnormal_nociception_after	1.82787784
22	MP0003693_abnormal_embryo_hatching	1.80920207
23	MP0006054_spinal_hemorrhage	1.80362590
24	MP0000465_gastrointestinal_hemorrhage	1.74078660
25	MP0005058_abnormal_lysosome_morphology	1.70874372
26	MP0001929_abnormal_gametogenesis	1.68409229
27	MP0002098_abnormal_vibrissa_morphology	1.60337556
28	MP0004233_abnormal_muscle_weight	1.57504028
29	MP0002163_abnormal_gland_morphology	1.57178563
30	MP0000647_abnormal_sebaceous_gland	1.55481638
31	MP0009053_abnormal_anal_canal	1.54738771
32	MP0003718_maternal_effect	1.52891913
33	MP0001145_abnormal_male_reproductive	1.48343435
34	MP0002160_abnormal_reproductive_system	1.47217031
35	MP0001968_abnormal_touch/_nociception	1.46606285
36	MP0010094_abnormal_chromosome_stability	1.46261385
37	MP0000653_abnormal_sex_gland	1.42724037
38	MP0003252_abnormal_bile_duct	1.39434766
39	MP0001666_abnormal_nutrient_absorption	1.34112250
40	MP0001764_abnormal_homeostasis	1.32367234
41	MP0004019_abnormal_vitamin_homeostasis	1.30474363
42	MP0005501_abnormal_skin_physiology	1.29527447
43	MP0008872_abnormal_physiological_respon	1.26877720
44	MP0004957_abnormal_blastocyst_morpholog	1.26098443
45	MP0000490_abnormal_crypts_of	1.23707613
46	MP0003195_calcinosis	1.23315902
47	MP0005360_urolithiasis	1.21482095
48	MP0002735_abnormal_chemical_nociception	1.18044725
49	MP0003567_abnormal_fetal_cardiomyocyte	1.16048492
50	MP0006035_abnormal_mitochondrial_morpho	1.12817103
51	MP0003698_abnormal_male_reproductive	1.10780920
52	MP0004270_analgesia	1.10593539
53	MP0010386_abnormal_urinary_bladder	1.09796184
54	MP0000858_altered_metastatic_potential	1.06236532
55	MP0003191_abnormal_cellular_cholesterol	1.05762152
56	MP0002127_abnormal_cardiovascular_syste	1.05541219
57	MP0005379_endocrine/exocrine_gland_phen	1.04359660
58	MP0002653_abnormal_ependyma_morphology	1.01171546
59	MP0005389_reproductive_system_phenotype	0.99805435
60	MP0004264_abnormal_extraembryonic_tissu	0.99594188
61	MP0003638_abnormal_response/metabolism_	0.99335209
62	MP0003111_abnormal_nucleus_morphology	0.97294017
63	MP0005332_abnormal_amino_acid	0.96802915
64	MP0005187_abnormal_penis_morphology	0.95957730
65	MP0005319_abnormal_enzyme/_coenzyme	0.94989270
66	MP0001765_abnormal_ion_homeostasis	0.92140200
67	MP0005636_abnormal_mineral_homeostasis	0.92052760
68	MP0003123_paternal_imprinting	0.92002084
69	MP0000569_abnormal_digit_pigmentation	0.91344018
70	MP0000534_abnormal_ureter_morphology	0.90845536
71	MP0003221_abnormal_cardiomyocyte_apopto	0.89879095
72	MP0000538_abnormal_urinary_bladder	0.88949899
73	MP0005085_abnormal_gallbladder_physiolo	0.88695239
74	MP0003699_abnormal_female_reproductive	0.88377539
75	MP0010678_abnormal_skin_adnexa	0.85981894
76	MP0003119_abnormal_digestive_system	0.85457733
77	MP0001730_embryonic_growth_arrest	0.85288952
78	MP0001216_abnormal_epidermal_layer	0.82083656
79	MP0003115_abnormal_respiratory_system	0.81902265
80	MP0005220_abnormal_exocrine_pancreas	0.81852909
81	MP0002161_abnormal_fertility/fecundity	0.81032974
82	MP0001119_abnormal_female_reproductive	0.80980710
83	MP0000358_abnormal_cell_content/	0.80921844
84	MP0004272_abnormal_basement_membrane	0.80731742
85	MP0003315_abnormal_perineum_morphology	0.78708115
86	MP0010771_integument_phenotype	0.76411999
87	MP0000467_abnormal_esophagus_morphology	0.74845216
88	MP0004147_increased_porphyrin_level	0.73263092
89	MP0003121_genomic_imprinting	0.72838973
90	MP0006036_abnormal_mitochondrial_physio	0.72620185
91	MP0002234_abnormal_pharynx_morphology	0.72419616
92	MP0000609_abnormal_liver_physiology	0.70311433
93	MP0001299_abnormal_eye_distance/	0.69560994
94	MP0005167_abnormal_blood-brain_barrier	0.64924770
95	MP0005083_abnormal_biliary_tract	0.64058046
96	MP0008873_increased_physiological_sensi	0.64054002
97	MP0005410_abnormal_fertilization	0.63557079
98	MP0004215_abnormal_myocardial_fiber	0.63181892
99	MP0001919_abnormal_reproductive_system	0.62596276
100	MP0009643_abnormal_urine_homeostasis	0.62533752

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.50323893
2	Opisthotonus (HP:0002179)	3.99219142
3	Septate vagina (HP:0001153)	3.68563472
4	Vaginal fistula (HP:0004320)	3.63361107
5	Glucose intolerance (HP:0000833)	3.61604000
6	Rectal fistula (HP:0100590)	3.56785114
7	Rectovaginal fistula (HP:0000143)	3.56785114
8	Vascular calcification (HP:0004934)	3.43968126
9	Joint hemorrhage (HP:0005261)	3.40676235
10	Azoospermia (HP:0000027)	3.18478803
11	High anterior hairline (HP:0009890)	3.18249466
12	Retinal atrophy (HP:0001105)	3.12625172
13	Intestinal fistula (HP:0100819)	3.04902024
14	Axonal loss (HP:0003447)	3.00453294
15	Hypoproteinemia (HP:0003075)	2.92703877
16	Prolonged partial thromboplastin time (HP:0003645)	2.91088473
17	Steatorrhea (HP:0002570)	2.90454795
18	Adrenal hypoplasia (HP:0000835)	2.85968389
19	Fair hair (HP:0002286)	2.82795023
20	Cardiovascular calcification (HP:0011915)	2.78190136
21	Methylmalonic aciduria (HP:0012120)	2.68537812
22	Amyloidosis (HP:0011034)	2.67702734
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.67228123
24	Methylmalonic acidemia (HP:0002912)	2.65323043
25	Delayed CNS myelination (HP:0002188)	2.65158208
26	Abnormality of the preputium (HP:0100587)	2.58650048
27	Abnormal spermatogenesis (HP:0008669)	2.55595684
28	Vacuolated lymphocytes (HP:0001922)	2.52651571
29	Renal cortical cysts (HP:0000803)	2.51263924
30	Micronodular cirrhosis (HP:0001413)	2.50133024
31	Prolonged neonatal jaundice (HP:0006579)	2.48686719
32	Conjugated hyperbilirubinemia (HP:0002908)	2.47205598
33	Absent speech (HP:0001344)	2.46386135
34	Upper limb muscle weakness (HP:0003484)	2.43074239
35	Fat malabsorption (HP:0002630)	2.42688057
36	Hyperglycinemia (HP:0002154)	2.42164279
37	Hyperventilation (HP:0002883)	2.39154564
38	Clitoromegaly (HP:0000057)	2.37513265
39	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.36867552
40	Abnormal glucose tolerance (HP:0001952)	2.32172532
41	J-shaped sella turcica (HP:0002680)	2.31532989
42	Type I transferrin isoform profile (HP:0003642)	2.30562377
43	Epileptic encephalopathy (HP:0200134)	2.29872731
44	Hepatic necrosis (HP:0002605)	2.17466122
45	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.15821953
46	Abnormal protein glycosylation (HP:0012346)	2.14182091
47	Abnormal glycosylation (HP:0012345)	2.14182091
48	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.14182091
49	Abnormal protein N-linked glycosylation (HP:0012347)	2.14182091
50	Shoulder girdle muscle weakness (HP:0003547)	2.07843179
51	Hepatocellular necrosis (HP:0001404)	2.07516435
52	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.05913113
53	Retinal dysplasia (HP:0007973)	2.04279316
54	Chromsome breakage (HP:0040012)	2.03631020
55	Submucous cleft hard palate (HP:0000176)	2.02433947
56	Abnormality of the columella (HP:0009929)	2.02151274
57	Pelvic girdle muscle weakness (HP:0003749)	2.01935527
58	Hypobetalipoproteinemia (HP:0003563)	2.01333922
59	Abnormality of alanine metabolism (HP:0010916)	2.00822760
60	Hyperalaninemia (HP:0003348)	2.00822760
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00822760
62	Brittle hair (HP:0002299)	2.00143839
63	Abnormal mitochondria in muscle tissue (HP:0008316)	1.99937331
64	Meckel diverticulum (HP:0002245)	1.99433517
65	Hyperglycemia (HP:0003074)	1.98654317
66	Entropion (HP:0000621)	1.97217841
67	Dicarboxylic aciduria (HP:0003215)	1.97184156
68	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.97184156
69	Short nail (HP:0001799)	1.97050519
70	Limb-girdle muscle atrophy (HP:0003797)	1.95584036
71	Reduced subcutaneous adipose tissue (HP:0003758)	1.95554654
72	Generalized hypopigmentation of hair (HP:0011358)	1.95535136
73	Abnormality of the ileum (HP:0001549)	1.95088428
74	Spastic tetraparesis (HP:0001285)	1.94978832
75	Renal hypoplasia (HP:0000089)	1.93025102
76	Abnormality of the musculature of the pelvis (HP:0001469)	1.91167404
77	Abnormality of the hip-girdle musculature (HP:0001445)	1.91167404
78	Severe muscular hypotonia (HP:0006829)	1.90413218
79	Renal tubular acidosis (HP:0001947)	1.90399606
80	Skull defect (HP:0001362)	1.89204887
81	X-linked dominant inheritance (HP:0001423)	1.87658925
82	Exocrine pancreatic insufficiency (HP:0001738)	1.86575119
83	Dysautonomia (HP:0002459)	1.85507489
84	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.85441010
85	Acute necrotizing encephalopathy (HP:0006965)	1.84637787
86	CNS demyelination (HP:0007305)	1.84103283
87	Aplasia cutis congenita (HP:0001057)	1.81837343
88	11 pairs of ribs (HP:0000878)	1.81387568
89	Toxemia of pregnancy (HP:0100603)	1.81232841
90	Ketosis (HP:0001946)	1.80403281
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76807280
92	Hand muscle atrophy (HP:0009130)	1.76463402
93	Abnormal respiratory epithelium morphology (HP:0012253)	1.76404943
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76404943
95	Tented upper lip vermilion (HP:0010804)	1.76253414
96	Increased serum lactate (HP:0002151)	1.75888541
97	Abnormality of the distal phalanges of the toes (HP:0010182)	1.75777835
98	Increased CSF lactate (HP:0002490)	1.73310815
99	Hyperlipoproteinemia (HP:0010980)	1.71445258
100	Lethargy (HP:0001254)	1.71409484

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	6.01301783
2	CCNB1	4.03111752
3	EPHA2	4.02798368
4	PBK	3.19480375
5	ZAK	3.18610287
6	TESK1	3.08832147
7	TLK1	2.95755736
8	BUB1	2.95702536
9	PDK2	2.88498809
10	TESK2	2.66182807
11	BCKDK	2.60297348
12	MAP4K2	2.47608118
13	VRK2	2.45964442
14	LIMK1	2.22737538
15	VRK1	2.13071000
16	MAPKAPK3	2.10561951
17	MAP3K12	1.94662888
18	TAOK1	1.78317041
19	DAPK1	1.72207951
20	LMTK2	1.71617326
21	MARK1	1.54557606
22	NUAK1	1.50748475
23	CDK19	1.43310841
24	SIK2	1.41096246
25	EPHA4	1.38035995
26	CSNK1G2	1.32394950
27	CSNK1G3	1.29482880
28	SMG1	1.26044620
29	OXSR1	1.22979981
30	CSNK1A1L	1.21447445
31	NME2	1.18279416
32	PAK4	1.16391476
33	PTK2B	1.06502688
34	MAPK13	1.05285120
35	ABL2	1.04685906
36	STK10	1.04534232
37	ERN1	1.04247288
38	STK38L	0.96771541
39	AURKA	0.87404339
40	GRK5	0.84580760
41	STK16	0.82907798
42	BLK	0.76412158
43	STK4	0.76007088
44	CSNK1G1	0.74865980
45	MST1R	0.69489857
46	NEK1	0.66246307
47	MAP3K3	0.63585992
48	CHEK2	0.60190131
49	PLK1	0.59962643
50	GRK6	0.58725959
51	CAMK4	0.57946115
52	RPS6KA5	0.55996535
53	SCYL2	0.55221467
54	TRIM28	0.55208712
55	MAP3K14	0.52694412
56	ILK	0.51577653
57	PAK1	0.50951157
58	STK38	0.50634845
59	CDK12	0.50461759
60	PRKCI	0.49325478
61	DAPK3	0.48457817
62	BRAF	0.47742076
63	PKN1	0.47599145
64	PIM2	0.47125570
65	AKT2	0.46838314
66	AURKB	0.41473111
67	CASK	0.40992226
68	UHMK1	0.40616531
69	CAMK2G	0.40529101
70	FRK	0.40310555
71	PTK6	0.39978983
72	RPS6KB2	0.39670837
73	MYLK	0.36695683
74	FER	0.36044364
75	ERBB2	0.35795186
76	PLK3	0.33023270
77	CDK9	0.32805685
78	TBK1	0.32568572
79	IKBKE	0.32516117
80	ARAF	0.30065974
81	CSNK1A1	0.29782246
82	IRAK2	0.29078819
83	CAMK2B	0.28958116
84	MAPKAPK2	0.28346751
85	CDK15	0.25833555
86	CDK11A	0.25067479
87	CHEK1	0.24720667
88	CDK18	0.24394461
89	ROCK1	0.23961676
90	PHKG2	0.23311738
91	PHKG1	0.23311738
92	CHUK	0.20027615
93	CDK14	0.19822908
94	IKBKB	0.19331831
95	CDK7	0.18945697
96	CSNK1E	0.18195320
97	PRKCZ	0.16813362
98	ATR	0.16231779
99	STK39	0.16110285
100	PIM1	0.15573186

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.13887178
2	Sulfur relay system_Homo sapiens_hsa04122	4.10528352
3	Folate biosynthesis_Homo sapiens_hsa00790	3.65146667
4	DNA replication_Homo sapiens_hsa03030	2.39335423
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.32330809
6	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.31989572
7	Alcoholism_Homo sapiens_hsa05034	2.27988159
8	Homologous recombination_Homo sapiens_hsa03440	2.10161626
9	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.09826072
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.98720823
11	Base excision repair_Homo sapiens_hsa03410	1.97812795
12	Phenylalanine metabolism_Homo sapiens_hsa00360	1.97506604
13	Fatty acid elongation_Homo sapiens_hsa00062	1.91705350
14	Glutathione metabolism_Homo sapiens_hsa00480	1.79107110
15	Fat digestion and absorption_Homo sapiens_hsa04975	1.67846699
16	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.66899886
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65062492
18	Pentose phosphate pathway_Homo sapiens_hsa00030	1.63451262
19	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.60208024
20	Parkinsons disease_Homo sapiens_hsa05012	1.57286512
21	Huntingtons disease_Homo sapiens_hsa05016	1.56654596
22	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.55104620
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.54331488
24	Mismatch repair_Homo sapiens_hsa03430	1.54051012
25	Vibrio cholerae infection_Homo sapiens_hsa05110	1.49323490
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.45796334
27	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.38969503
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.37512145
29	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.37248629
30	Fatty acid degradation_Homo sapiens_hsa00071	1.36183508
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.33907412
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.33106136
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30857784
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29722776
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.27415282
36	Peroxisome_Homo sapiens_hsa04146	1.26809255
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.24257485
38	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.23254728
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21550207
40	RNA polymerase_Homo sapiens_hsa03020	1.21102510
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19367430
42	Arginine biosynthesis_Homo sapiens_hsa00220	1.18665543
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.16610318
44	Tyrosine metabolism_Homo sapiens_hsa00350	1.13005477
45	Histidine metabolism_Homo sapiens_hsa00340	1.09782383
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03095536
47	Sulfur metabolism_Homo sapiens_hsa00920	1.02719316
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98819748
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.98661215
50	Cell cycle_Homo sapiens_hsa04110	0.97720689
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97613317
52	Pancreatic secretion_Homo sapiens_hsa04972	0.96709455
53	Viral carcinogenesis_Homo sapiens_hsa05203	0.96041157
54	Spliceosome_Homo sapiens_hsa03040	0.94983847
55	Galactose metabolism_Homo sapiens_hsa00052	0.92648814
56	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.90436229
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89675896
58	Carbon metabolism_Homo sapiens_hsa01200	0.87474544
59	Regulation of autophagy_Homo sapiens_hsa04140	0.87386406
60	Legionellosis_Homo sapiens_hsa05134	0.87306127
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84921523
62	Alzheimers disease_Homo sapiens_hsa05010	0.84121739
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.82834072
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.81636789
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.81563675
66	Other glycan degradation_Homo sapiens_hsa00511	0.81223496
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.80683085
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75849835
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75395134
70	Purine metabolism_Homo sapiens_hsa00230	0.73868758
71	Oocyte meiosis_Homo sapiens_hsa04114	0.72430299
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71914650
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.71909500
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.71672815
75	Metabolic pathways_Homo sapiens_hsa01100	0.69380800
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63403776
77	Salivary secretion_Homo sapiens_hsa04970	0.62917678
78	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.62465528
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56834829
80	Retinol metabolism_Homo sapiens_hsa00830	0.55125041
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.52065060
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51199513
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49772075
84	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49612636
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48547127
86	Lysosome_Homo sapiens_hsa04142	0.47556854
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47277553
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46490927
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46330162
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45028418
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41207693
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.39040918
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34966757
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31744042
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.30868336
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30791876
97	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.27887956
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24444736
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.23988906
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23447838

KRT8P43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »