KRT8P45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.05841635
2homocysteine metabolic process (GO:0050667)7.44329773
3folic acid-containing compound biosynthetic process (GO:0009396)6.38589210
4regulation of plasminogen activation (GO:0010755)6.18007626
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.06388655
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.06388655
7sulfur amino acid catabolic process (GO:0000098)5.85546923
8galactose catabolic process (GO:0019388)5.84258592
9regulation of gonadotropin secretion (GO:0032276)5.75971654
10cysteine metabolic process (GO:0006534)5.45786439
11purine nucleotide salvage (GO:0032261)5.30995536
12adenosine metabolic process (GO:0046085)5.21478099
13pteridine-containing compound biosynthetic process (GO:0042559)5.14125941
14aminoglycoside antibiotic metabolic process (GO:0030647)5.00773330
15galactose metabolic process (GO:0006012)5.00070070
16mitochondrial RNA metabolic process (GO:0000959)4.80958239
17IMP biosynthetic process (GO:0006188)4.72255127
18regulation of vitamin metabolic process (GO:0030656)4.39361993
19glycoside metabolic process (GO:0016137)4.32634310
20nucleoside transmembrane transport (GO:1901642)4.32531977
21L-serine metabolic process (GO:0006563)4.29844556
22white fat cell differentiation (GO:0050872)4.19296180
23regulation of vitamin D biosynthetic process (GO:0060556)4.08838120
24negative regulation of keratinocyte proliferation (GO:0010839)4.07544170
25IMP metabolic process (GO:0046040)3.82423370
264-hydroxyproline metabolic process (GO:0019471)3.79919765
27positive regulation of endothelial cell differentiation (GO:0045603)3.78225731
28polyamine biosynthetic process (GO:0006596)3.69349545
29microtubule nucleation (GO:0007020)3.65899869
30polyketide metabolic process (GO:0030638)3.61851077
31doxorubicin metabolic process (GO:0044598)3.61851077
32daunorubicin metabolic process (GO:0044597)3.61851077
33nucleotide salvage (GO:0043173)3.54762602
34CENP-A containing nucleosome assembly (GO:0034080)3.53156851
35epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.52110974
36regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.51212026
37glycolipid catabolic process (GO:0019377)3.50961938
38nucleoside transport (GO:0015858)3.50896699
39organic cation transport (GO:0015695)3.49418162
40proteasome assembly (GO:0043248)3.47564291
41regulation of tight junction assembly (GO:2000810)3.44746787
42negative regulation of DNA biosynthetic process (GO:2000279)3.38664835
43hepatocyte apoptotic process (GO:0097284)3.36960836
44phosphatidylglycerol biosynthetic process (GO:0006655)3.36717933
45alternative mRNA splicing, via spliceosome (GO:0000380)3.36078277
46COPII vesicle coating (GO:0048208)3.34088157
47serine family amino acid biosynthetic process (GO:0009070)3.33643789
48sulfur amino acid biosynthetic process (GO:0000097)3.30387331
49peptidyl-proline hydroxylation (GO:0019511)3.26204870
50folic acid-containing compound metabolic process (GO:0006760)3.24253625
51glycosphingolipid catabolic process (GO:0046479)3.22033858
52ribosome biogenesis (GO:0042254)3.19733166
53peptidyl-arginine omega-N-methylation (GO:0035247)3.11257699
54chromatin remodeling at centromere (GO:0031055)3.10704459
55energy homeostasis (GO:0097009)3.08168433
56pteridine-containing compound metabolic process (GO:0042558)3.06725457
57rRNA methylation (GO:0031167)3.06047049
58negative regulation of stem cell proliferation (GO:2000647)3.05034399
59negative regulation of chondrocyte differentiation (GO:0032331)3.02984863
60negative regulation of Ras GTPase activity (GO:0034261)3.00404339
61tetrahydrofolate metabolic process (GO:0046653)2.98477020
62polyamine metabolic process (GO:0006595)2.97005823
63viral mRNA export from host cell nucleus (GO:0046784)2.94002293
64ATP hydrolysis coupled proton transport (GO:0015991)2.93702627
65energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93702627
66primary alcohol catabolic process (GO:0034310)2.91555355
67peptidyl-arginine N-methylation (GO:0035246)2.90200831
68peptidyl-arginine methylation (GO:0018216)2.90200831
69primary amino compound metabolic process (GO:1901160)2.89792385
70negative regulation of catenin import into nucleus (GO:0035414)2.89249581
71folic acid transport (GO:0015884)2.87514380
72artery smooth muscle contraction (GO:0014824)2.87050764
73tRNA modification (GO:0006400)2.83944091
74growth hormone secretion (GO:0030252)2.83445073
75rRNA modification (GO:0000154)2.82793296
76sulfur amino acid metabolic process (GO:0000096)2.81255536
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.80794359
78NADH dehydrogenase complex assembly (GO:0010257)2.80794359
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80794359
80positive regulation of growth hormone secretion (GO:0060124)2.80751480
81placenta development (GO:0001890)2.79548684
82calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.78472372
83protein hydroxylation (GO:0018126)2.78356505
84response to vitamin A (GO:0033189)2.74396928
85regulation of endothelial cell differentiation (GO:0045601)2.74132443
86heme transport (GO:0015886)2.73493667
87pseudouridine synthesis (GO:0001522)2.65563671
88folic acid metabolic process (GO:0046655)2.65047013
89transferrin transport (GO:0033572)2.64511586
90ceramide catabolic process (GO:0046514)2.63760746
91guanosine-containing compound biosynthetic process (GO:1901070)2.63726635
92protein-chromophore linkage (GO:0018298)2.62034971
93inner ear receptor cell development (GO:0060119)2.61066890
94alpha-amino acid biosynthetic process (GO:1901607)2.58558876
95response to lipoprotein particle (GO:0055094)2.54985882
96inner mitochondrial membrane organization (GO:0007007)2.54649944
97amine biosynthetic process (GO:0009309)2.53356224
98DNA replication-independent nucleosome organization (GO:0034724)2.51992256
99DNA replication-independent nucleosome assembly (GO:0006336)2.51992256
100cellular biogenic amine biosynthetic process (GO:0042401)2.51820649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.88448593
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.71451328
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.28289588
4AR_21909140_ChIP-Seq_LNCAP_Human2.81135927
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.79892937
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71984361
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68123023
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.64612210
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.56080514
10ZNF263_19887448_ChIP-Seq_K562_Human2.54750803
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51274010
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33398562
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30817354
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22822349
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.16374345
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.14082265
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11897141
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98489768
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92626241
20E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92455512
21E2F7_22180533_ChIP-Seq_HELA_Human1.88398088
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.84623767
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79518723
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78520532
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77519036
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77228182
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73393432
28GABP_19822575_ChIP-Seq_HepG2_Human1.70628397
29DCP1A_22483619_ChIP-Seq_HELA_Human1.68539616
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66748554
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64816492
32SOX2_20726797_ChIP-Seq_SW620_Human1.64535874
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64390469
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63907631
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.62728533
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57969251
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54430956
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54260903
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53772226
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52632903
41ATF3_27146783_Chip-Seq_COLON_Human1.50863942
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.50246143
43XRN2_22483619_ChIP-Seq_HELA_Human1.48548813
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47533002
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46148941
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41954315
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39388156
48TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39106416
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38388957
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.37084789
51GATA4_25053715_ChIP-Seq_YYC3_Human1.37005171
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36663008
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36598872
54CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35489847
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34523392
56RACK7_27058665_Chip-Seq_MCF-7_Human1.34089386
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32781968
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30038902
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.29865290
60TBX5_21415370_ChIP-Seq_HL-1_Mouse1.29822941
61GATA6_25053715_ChIP-Seq_YYC3_Human1.29027704
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28571732
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27560529
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.25678656
65GATA3_24758297_ChIP-Seq_MCF-7_Human1.24356846
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23882035
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23752882
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23199534
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22086217
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21873032
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21116433
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15806728
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15769035
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15769035
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.15584184
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15011837
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10579730
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10570043
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10339339
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07675854
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07505070
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06969509
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06312436
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06251608
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.06172926
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05111488
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.05036493
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03421052
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02563578
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02454613
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01057783
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.00251539
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00088705
94MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99724821
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99026682
96THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98713173
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97961566
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97079230
99BCOR_27268052_Chip-Seq_Bcells_Human0.96710545
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96245383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.27180002
2MP0002163_abnormal_gland_morphology3.95728949
3MP0010234_abnormal_vibrissa_follicle3.85195176
4MP0005670_abnormal_white_adipose3.63285963
5MP0003806_abnormal_nucleotide_metabolis3.60964505
6MP0002139_abnormal_hepatobiliary_system3.09340346
7MP0003183_abnormal_peptide_metabolism3.01777520
8MP0005646_abnormal_pituitary_gland2.71500235
9MP0000013_abnormal_adipose_tissue2.70609234
10MP0003693_abnormal_embryo_hatching2.66373278
11MP0000647_abnormal_sebaceous_gland2.41124641
12MP0000516_abnormal_urinary_system2.25274880
13MP0005367_renal/urinary_system_phenotyp2.25274880
14MP0005379_endocrine/exocrine_gland_phen2.23426369
15MP0010678_abnormal_skin_adnexa2.08581168
16MP0002132_abnormal_respiratory_system2.06004865
17MP0002254_reproductive_system_inflammat2.04378493
18MP0001764_abnormal_homeostasis1.96869855
19MP0000383_abnormal_hair_follicle1.93360207
20MP0004147_increased_porphyrin_level1.90484140
21MP0008872_abnormal_physiological_respon1.87855422
22MP0005365_abnormal_bile_salt1.83304426
23MP0001666_abnormal_nutrient_absorption1.80886161
24MP0003705_abnormal_hypodermis_morpholog1.80272547
25MP0004264_abnormal_extraembryonic_tissu1.80093042
26MP0004019_abnormal_vitamin_homeostasis1.79769134
27MP0008995_early_reproductive_senescence1.77432604
28MP0005332_abnormal_amino_acid1.76064872
29MP0002138_abnormal_hepatobiliary_system1.74949118
30MP0002736_abnormal_nociception_after1.74459933
31MP0003186_abnormal_redox_activity1.67333268
32MP0000613_abnormal_salivary_gland1.58639619
33MP0005085_abnormal_gallbladder_physiolo1.56530282
34MP0002796_impaired_skin_barrier1.52494660
35MP0003191_abnormal_cellular_cholesterol1.49225697
36MP0002938_white_spotting1.39773545
37MP0008875_abnormal_xenobiotic_pharmacok1.39748519
38MP0001661_extended_life_span1.36303227
39MP0000750_abnormal_muscle_regeneration1.32258312
40MP0000579_abnormal_nail_morphology1.30689476
41MP0005451_abnormal_body_composition1.28691431
42MP0001216_abnormal_epidermal_layer1.28360917
43MP0009643_abnormal_urine_homeostasis1.24892530
44MP0004185_abnormal_adipocyte_glucose1.24722431
45MP0009697_abnormal_copulation1.23735461
46MP0000534_abnormal_ureter_morphology1.22439022
47MP0005076_abnormal_cell_differentiation1.19334867
48MP0002098_abnormal_vibrissa_morphology1.17703925
49MP0005083_abnormal_biliary_tract1.17067985
50MP0000467_abnormal_esophagus_morphology1.16340675
51MP0009840_abnormal_foam_cell1.14694373
52MP0003315_abnormal_perineum_morphology1.12822987
53MP0003786_premature_aging1.08856393
54MP0001756_abnormal_urination1.08305858
55MP0004957_abnormal_blastocyst_morpholog1.07345554
56MP0000762_abnormal_tongue_morphology1.06882192
57MP0005647_abnormal_sex_gland1.06678032
58MP0000537_abnormal_urethra_morphology1.06250795
59MP0003718_maternal_effect1.06059351
60MP0003638_abnormal_response/metabolism_1.01406725
61MP0004233_abnormal_muscle_weight1.01203329
62MP0000003_abnormal_adipose_tissue0.98806338
63MP0000462_abnormal_digestive_system0.97396562
64MP0005084_abnormal_gallbladder_morpholo0.93318904
65MP0003942_abnormal_urinary_system0.88501149
66MP0005501_abnormal_skin_physiology0.87603381
67MP0010352_gastrointestinal_tract_polyps0.87587454
68MP0000566_synostosis0.86986466
69MP0000627_abnormal_mammary_gland0.86257639
70MP0003878_abnormal_ear_physiology0.83669498
71MP0005377_hearing/vestibular/ear_phenot0.83669498
72MP0003724_increased_susceptibility_to0.82332010
73MP0001944_abnormal_pancreas_morphology0.79722735
74MP0005636_abnormal_mineral_homeostasis0.79458045
75MP0005376_homeostasis/metabolism_phenot0.78233579
76MP0000538_abnormal_urinary_bladder0.78193073
77MP0003936_abnormal_reproductive_system0.77964418
78MP0005164_abnormal_response_to0.75228302
79MP0000678_abnormal_parathyroid_gland0.74689939
80MP0000377_abnormal_hair_follicle0.73996628
81MP0010771_integument_phenotype0.72781515
82MP0001340_abnormal_eyelid_morphology0.72512810
83MP0003453_abnormal_keratinocyte_physiol0.71691477
84MP0000747_muscle_weakness0.68238945
85MP0003566_abnormal_cell_adhesion0.68141684
86MP0005319_abnormal_enzyme/_coenzyme0.67672551
87MP0005248_abnormal_Harderian_gland0.66368652
88MP0005410_abnormal_fertilization0.65149827
89MP0001243_abnormal_dermal_layer0.63413331
90MP0002697_abnormal_eye_size0.63225913
91MP0005584_abnormal_enzyme/coenzyme_acti0.57549473
92MP0000490_abnormal_crypts_of0.56167161
93MP0010030_abnormal_orbit_morphology0.56137681
94MP0002877_abnormal_melanocyte_morpholog0.55875659
95MP0001730_embryonic_growth_arrest0.55812745
96MP0003123_paternal_imprinting0.55079162
97MP0001727_abnormal_embryo_implantation0.54345557
98MP0002396_abnormal_hematopoietic_system0.54244021
99MP0005197_abnormal_uvea_morphology0.53927811
100MP0002295_abnormal_pulmonary_circulatio0.53828541

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.92593660
2Abnormality of alanine metabolism (HP:0010916)6.92593660
3Hyperalaninemia (HP:0003348)6.92593660
4Esophageal varix (HP:0002040)4.80751649
5Abnormality of the fetal cardiovascular system (HP:0010948)4.77298524
6Abnormal umbilical cord blood vessels (HP:0011403)4.77298524
7Single umbilical artery (HP:0001195)4.77298524
8Constricted visual fields (HP:0001133)4.39377404
9Congenital sensorineural hearing impairment (HP:0008527)4.23006727
10Decreased electroretinogram (ERG) amplitude (HP:0000654)3.74056868
11Abnormality of the umbilical cord (HP:0010881)3.69615276
12White forelock (HP:0002211)3.53440961
13Abnormality of serum amino acid levels (HP:0003112)3.46538210
14Patchy hypopigmentation of hair (HP:0011365)3.41475619
15Abnormality of sulfur amino acid metabolism (HP:0004339)3.41031198
16Homocystinuria (HP:0002156)3.34637594
17Abnormality of homocysteine metabolism (HP:0010919)3.34637594
18Myocardial infarction (HP:0001658)3.27608302
19Hypoalphalipoproteinemia (HP:0003233)3.24962019
20Intrahepatic cholestasis (HP:0001406)3.21122951
21Conjugated hyperbilirubinemia (HP:0002908)2.95046762
22Generalized aminoaciduria (HP:0002909)2.89217827
23Ileus (HP:0002595)2.83495890
24Nausea (HP:0002018)2.79783150
25Birth length less than 3rd percentile (HP:0003561)2.79493112
26Reduced subcutaneous adipose tissue (HP:0003758)2.68557372
27Insulin-resistant diabetes mellitus (HP:0000831)2.57015315
28Abnormalities of placenta or umbilical cord (HP:0001194)2.55185174
29Poor speech (HP:0002465)2.54615736
30Anorexia (HP:0002039)2.52799478
31Abnormality of methionine metabolism (HP:0010901)2.52764023
32Micronodular cirrhosis (HP:0001413)2.46182433
33Brittle hair (HP:0002299)2.34792792
34Abnormality of liposaccharide metabolism (HP:0010968)2.33573408
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.33573408
36Abnormality of glycolipid metabolism (HP:0010969)2.33573408
37Proximal tubulopathy (HP:0000114)2.31450064
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27155753
39Delayed CNS myelination (HP:0002188)2.25205209
40Abnormal tarsal ossification (HP:0008369)2.23878711
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21901734
42Hypoplasia of the uterus (HP:0000013)2.21400472
43Hypolipoproteinemia (HP:0010981)2.19035829
44Cortical visual impairment (HP:0100704)2.18951010
45Hyperglycemia (HP:0003074)2.16577327
46Focal segmental glomerulosclerosis (HP:0000097)2.16222649
47Myopathic facies (HP:0002058)2.16209009
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15385507
49Diaphragmatic weakness (HP:0009113)2.14992864
50Hyperglycinemia (HP:0002154)2.14459769
51Hypoplastic left heart (HP:0004383)2.12768084
52Reduced antithrombin III activity (HP:0001976)2.12371518
53Abnormality of glycolysis (HP:0004366)2.09839623
54Heterochromia iridis (HP:0001100)2.05479784
55Abnormality of pyrimidine metabolism (HP:0004353)2.04707553
56Megaloblastic anemia (HP:0001889)2.01649658
57Conjunctival telangiectasia (HP:0000524)2.00274065
58Maternal diabetes (HP:0009800)1.98818429
59Hyperphosphaturia (HP:0003109)1.98206936
60Increased serum pyruvate (HP:0003542)1.98067318
61Pigmentary retinal degeneration (HP:0001146)1.96825237
62Abnormality of the distal phalanges of the toes (HP:0010182)1.96523206
63Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96308137
64Spontaneous hematomas (HP:0007420)1.95801006
65Abnormality of alkaline phosphatase activity (HP:0004379)1.94612995
66Metabolic acidosis (HP:0001942)1.93970864
67Type I transferrin isoform profile (HP:0003642)1.93340658
68Hypokinesia (HP:0002375)1.91118569
69Increased serum lactate (HP:0002151)1.90293511
70Aplasia/hypoplasia of the uterus (HP:0008684)1.89551007
71Congenital ichthyosiform erythroderma (HP:0007431)1.89426191
72Lactic acidosis (HP:0003128)1.88668054
73Tongue fasciculations (HP:0001308)1.86913662
74Symptomatic seizures (HP:0011145)1.86842470
75Fat malabsorption (HP:0002630)1.86770141
76Elevated alkaline phosphatase (HP:0003155)1.86727988
77Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85318484
78Abnormal enzyme/coenzyme activity (HP:0012379)1.83493787
79Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83269350
80Hyperuricemia (HP:0002149)1.83132514
81Increased purine levels (HP:0004368)1.83132514
82Right ventricular cardiomyopathy (HP:0011663)1.82644127
83Stenosis of the external auditory canal (HP:0000402)1.82606525
84Decreased subcutaneous fat (HP:0001002)1.82605435
85Cone-rod dystrophy (HP:0000548)1.82011251
86Glucose intolerance (HP:0000833)1.80013221
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80012823
88Oligomenorrhea (HP:0000876)1.79793045
89Hypergonadotropic hypogonadism (HP:0000815)1.79387727
90Lethargy (HP:0001254)1.79053598
91Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78396184
92Ureteral duplication (HP:0000073)1.78365811
93Steatorrhea (HP:0002570)1.77698693
94Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76133085
95Glomerulosclerosis (HP:0000096)1.75449032
96Progressive muscle weakness (HP:0003323)1.74646509
97Chromsome breakage (HP:0040012)1.71331609
98Vacuolated lymphocytes (HP:0001922)1.70465820
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69344215
100Dicarboxylic aciduria (HP:0003215)1.69344215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.76870125
2LMTK25.03006996
3TLK13.86517946
4MST1R3.80317224
5MAP3K33.60123051
6RPS6KB22.69040034
7MST42.26018731
8VRK22.25679968
9NME22.19116939
10ZAK2.11179501
11BLK2.08560346
12PAK42.03718379
13TESK12.00323973
14BCKDK2.00302314
15CDK91.93705382
16BUB11.87670371
17FGR1.74465030
18ACVR1B1.69871509
19LIMK11.68794620
20VRK11.67785129
21DAPK21.66146836
22MAP2K31.64658550
23TESK21.60535119
24MAP3K121.45831391
25MET1.43317724
26PBK1.38926609
27TRIM281.35614890
28NEK11.32453322
29AURKA1.31530420
30PRKG21.28349180
31PDK21.25992006
32EPHB21.23340321
33SIK11.18692348
34EIF2AK11.17481379
35IRAK31.14399502
36STK161.04833221
37CCNB11.03224363
38NME11.00168869
39DAPK10.97870844
40CAMK2D0.97647720
41CAMK2G0.96192907
42STK390.96113185
43CAMK2B0.90148521
44DAPK30.87102333
45EIF2AK30.84304885
46PTK60.83352453
47JAK30.82968583
48ERN10.80925239
49PIM20.79897912
50MAP2K70.77900970
51CSNK1G30.75295106
52OXSR10.74018270
53PRKCI0.72088041
54SMG10.70853060
55MAP3K110.63664235
56CSNK1A1L0.63404170
57STK100.62852682
58CSNK1A10.61097405
59TNIK0.59210979
60MAP4K20.59152176
61ABL20.54805695
62MAP2K10.54515390
63IKBKB0.53521138
64AKT20.52590094
65CSNK1G10.52485645
66AURKB0.52109299
67PHKG20.51348483
68PHKG10.51348483
69ERBB40.51190664
70FGFR10.50297632
71PIK3CA0.49161034
72SGK2230.47645936
73SGK4940.47645936
74CDK70.46932473
75NEK60.41631699
76RPS6KA50.40457107
77RPS6KA40.40253047
78MAPKAPK50.40021004
79DYRK30.39704811
80CHUK0.39352738
81FER0.36948821
82BRSK10.36538120
83ADRBK10.36473999
84WEE10.35792051
85PRKCD0.35723241
86EPHA40.35695869
87SRPK10.34431977
88PRKCE0.34266135
89EIF2AK20.34019608
90CSNK1G20.32908360
91DYRK20.32445896
92EGFR0.32148882
93TSSK60.32093304
94PAK10.31107017
95TAF10.30335440
96ROCK10.30086261
97MAPKAPK20.29405403
98MAP3K90.29018435
99TBK10.26073468
100SIK30.25509067

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.26175972
2Sulfur metabolism_Homo sapiens_hsa009203.08434674
3Galactose metabolism_Homo sapiens_hsa000523.05173028
4Arginine biosynthesis_Homo sapiens_hsa002202.88220391
5Collecting duct acid secretion_Homo sapiens_hsa049662.85134946
6Proteasome_Homo sapiens_hsa030502.78196740
7Vibrio cholerae infection_Homo sapiens_hsa051102.61383449
8Sulfur relay system_Homo sapiens_hsa041222.60741261
9One carbon pool by folate_Homo sapiens_hsa006702.54807266
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.46716796
11Biosynthesis of amino acids_Homo sapiens_hsa012302.18259542
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.06404968
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.04029869
14Vitamin digestion and absorption_Homo sapiens_hsa049772.01750225
15Other glycan degradation_Homo sapiens_hsa005112.00430546
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.88298108
17Selenocompound metabolism_Homo sapiens_hsa004501.85667048
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82037599
19Systemic lupus erythematosus_Homo sapiens_hsa053221.81415751
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76116522
21Oxidative phosphorylation_Homo sapiens_hsa001901.72502040
22Glutathione metabolism_Homo sapiens_hsa004801.70709453
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68499615
24Folate biosynthesis_Homo sapiens_hsa007901.57029235
25Fructose and mannose metabolism_Homo sapiens_hsa000511.56262457
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55163139
27Carbon metabolism_Homo sapiens_hsa012001.46042224
28Phenylalanine metabolism_Homo sapiens_hsa003601.46000262
29Pentose phosphate pathway_Homo sapiens_hsa000301.43856001
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40144570
31Arginine and proline metabolism_Homo sapiens_hsa003301.39627122
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34623801
33Alcoholism_Homo sapiens_hsa050341.33326548
34Fat digestion and absorption_Homo sapiens_hsa049751.25591460
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06975041
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05702738
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05281246
38DNA replication_Homo sapiens_hsa030301.05134893
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03858309
40Fatty acid elongation_Homo sapiens_hsa000620.99643100
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97754407
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96455095
43Starch and sucrose metabolism_Homo sapiens_hsa005000.96193548
44Pyruvate metabolism_Homo sapiens_hsa006200.94707731
45Mismatch repair_Homo sapiens_hsa034300.93641347
46Retinol metabolism_Homo sapiens_hsa008300.92066687
47Pyrimidine metabolism_Homo sapiens_hsa002400.88789288
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87324940
49Metabolic pathways_Homo sapiens_hsa011000.85129123
50Spliceosome_Homo sapiens_hsa030400.82875253
51Huntingtons disease_Homo sapiens_hsa050160.82358365
52Chemical carcinogenesis_Homo sapiens_hsa052040.81988040
53Steroid biosynthesis_Homo sapiens_hsa001000.81890451
54Parkinsons disease_Homo sapiens_hsa050120.81254290
55Homologous recombination_Homo sapiens_hsa034400.80522016
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78599397
57Peroxisome_Homo sapiens_hsa041460.78495528
58RNA polymerase_Homo sapiens_hsa030200.78299214
59Base excision repair_Homo sapiens_hsa034100.77792061
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77582735
61Synaptic vesicle cycle_Homo sapiens_hsa047210.75414305
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71419308
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71380972
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70842503
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69274206
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.68604078
67Histidine metabolism_Homo sapiens_hsa003400.68279981
68Lysosome_Homo sapiens_hsa041420.67731626
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66053391
70Regulation of autophagy_Homo sapiens_hsa041400.65015066
71RNA transport_Homo sapiens_hsa030130.59987355
72Tryptophan metabolism_Homo sapiens_hsa003800.58996772
73Sphingolipid metabolism_Homo sapiens_hsa006000.58254202
74Purine metabolism_Homo sapiens_hsa002300.55918762
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55802570
76Tyrosine metabolism_Homo sapiens_hsa003500.54591669
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53606764
78N-Glycan biosynthesis_Homo sapiens_hsa005100.52740937
79Rheumatoid arthritis_Homo sapiens_hsa053230.52524979
80Alzheimers disease_Homo sapiens_hsa050100.52159650
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.50436721
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48514392
83Thyroid cancer_Homo sapiens_hsa052160.48320325
84Tight junction_Homo sapiens_hsa045300.46961919
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46857944
86Basal transcription factors_Homo sapiens_hsa030220.45942716
87Renin-angiotensin system_Homo sapiens_hsa046140.45753271
88Propanoate metabolism_Homo sapiens_hsa006400.44459839
89Fanconi anemia pathway_Homo sapiens_hsa034600.40280819
90Legionellosis_Homo sapiens_hsa051340.39981282
91Arachidonic acid metabolism_Homo sapiens_hsa005900.39526562
92Bile secretion_Homo sapiens_hsa049760.38708910
93Nucleotide excision repair_Homo sapiens_hsa034200.38185881
94Pancreatic secretion_Homo sapiens_hsa049720.37948564
95beta-Alanine metabolism_Homo sapiens_hsa004100.37675612
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37435905
97Nitrogen metabolism_Homo sapiens_hsa009100.36135198
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34670065
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.34422746
100Ribosome_Homo sapiens_hsa030100.34105002

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