ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingomyelin metabolic process (GO:0006684)	5.51542426
2	auditory receptor cell differentiation (GO:0042491)	5.38362167
3	protein maturation by protein folding (GO:0022417)	5.25352338
4	midgut development (GO:0007494)	5.16113598
5	GDP-mannose metabolic process (GO:0019673)	4.98678797
6	regulation of metalloenzyme activity (GO:0048552)	4.76054239
7	NADH metabolic process (GO:0006734)	4.44342133
8	regulation of vitamin metabolic process (GO:0030656)	4.41650223
9	antibacterial humoral response (GO:0019731)	4.26331126
10	positive regulation of pseudopodium assembly (GO:0031274)	4.25569480
11	intestinal absorption (GO:0050892)	4.03927349
12	antimicrobial humoral response (GO:0019730)	4.01971700
13	nucleoside diphosphate biosynthetic process (GO:0009133)	4.01236732
14	nucleotide-sugar biosynthetic process (GO:0009226)	3.97424397
15	sulfation (GO:0051923)	3.89414415
16	Golgi transport vesicle coating (GO:0048200)	3.85425973
17	COPI coating of Golgi vesicle (GO:0048205)	3.85425973
18	regulation of guanylate cyclase activity (GO:0031282)	3.82089011
19	protein retention in ER lumen (GO:0006621)	3.80552726
20	regulation of pseudopodium assembly (GO:0031272)	3.71851593
21	L-ascorbic acid metabolic process (GO:0019852)	3.70514325
22	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.69085602
23	negative regulation of cell fate specification (GO:0009996)	3.65766009
24	daunorubicin metabolic process (GO:0044597)	3.64373128
25	polyketide metabolic process (GO:0030638)	3.64373128
26	doxorubicin metabolic process (GO:0044598)	3.64373128
27	angiotensin maturation (GO:0002003)	3.61867553
28	regulation of bile acid biosynthetic process (GO:0070857)	3.56469816
29	hair cell differentiation (GO:0035315)	3.46969831
30	urea cycle (GO:0000050)	3.43431735
31	cellular response to zinc ion (GO:0071294)	3.39776385
32	eosinophil chemotaxis (GO:0048245)	3.39206770
33	fructose metabolic process (GO:0006000)	3.38845786
34	cyclooxygenase pathway (GO:0019371)	3.38680408
35	desmosome organization (GO:0002934)	3.36583706
36	positive regulation of lipoprotein lipase activity (GO:0051006)	3.28309694
37	positive regulation of triglyceride lipase activity (GO:0061365)	3.28309694
38	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.27418979
39	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.27418979
40	oligosaccharide biosynthetic process (GO:0009312)	3.26849375
41	regulation of cGMP metabolic process (GO:0030823)	3.23849281
42	cell adhesion mediated by integrin (GO:0033627)	3.23624524
43	aminoglycoside antibiotic metabolic process (GO:0030647)	3.20620115
44	glutamine family amino acid biosynthetic process (GO:0009084)	3.16355886
45	regulation of integrin-mediated signaling pathway (GO:2001044)	3.15730229
46	regulation of vitamin D biosynthetic process (GO:0060556)	3.13235330
47	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.12997090
48	urea metabolic process (GO:0019627)	3.10709793
49	cellular response to cadmium ion (GO:0071276)	3.10431838
50	negative regulation of epidermal cell differentiation (GO:0045605)	3.09861364
51	nucleobase-containing small molecule interconversion (GO:0015949)	3.07996127
52	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.05262515
53	regulation of gonadotropin secretion (GO:0032276)	2.97833411
54	inner ear receptor cell differentiation (GO:0060113)	2.97803825
55	eosinophil migration (GO:0072677)	2.97698604
56	lipoprotein transport (GO:0042953)	2.95354497
57	regulation of cholesterol homeostasis (GO:2000188)	2.95305014
58	endocrine hormone secretion (GO:0060986)	2.94230262
59	positive regulation of guanylate cyclase activity (GO:0031284)	2.87970613
60	actin filament depolymerization (GO:0030042)	2.87178048
61	positive regulation of glycoprotein metabolic process (GO:1903020)	2.82924899
62	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.82025797
63	endocrine process (GO:0050886)	2.82025797
64	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.82025797
65	renal absorption (GO:0070293)	2.81268666
66	wound healing, spreading of epidermal cells (GO:0035313)	2.80827394
67	C21-steroid hormone biosynthetic process (GO:0006700)	2.80728533
68	regulation of keratinocyte proliferation (GO:0010837)	2.79835068
69	regulation of cellular extravasation (GO:0002691)	2.76663848
70	regulation of transforming growth factor beta2 production (GO:0032909)	2.76662675
71	arginine metabolic process (GO:0006525)	2.76245038
72	prostanoid metabolic process (GO:0006692)	2.72819854
73	prostaglandin metabolic process (GO:0006693)	2.72819854
74	xenobiotic catabolic process (GO:0042178)	2.71612420
75	cobalamin metabolic process (GO:0009235)	2.69143146
76	prostaglandin biosynthetic process (GO:0001516)	2.67067197
77	prostanoid biosynthetic process (GO:0046457)	2.67067197
78	galactose catabolic process (GO:0019388)	2.66868336
79	glycoside metabolic process (GO:0016137)	2.66577477
80	inositol phosphate-mediated signaling (GO:0048016)	2.60266517
81	ER overload response (GO:0006983)	2.59441250
82	nitrogen cycle metabolic process (GO:0071941)	2.59126817
83	negative regulation of stem cell proliferation (GO:2000647)	2.57135308
84	homocysteine metabolic process (GO:0050667)	2.56228821
85	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.55931971
86	positive regulation of interleukin-8 secretion (GO:2000484)	2.55452960
87	positive regulation of cartilage development (GO:0061036)	2.54798720
88	ribosome assembly (GO:0042255)	2.53453621
89	negative regulation of steroid biosynthetic process (GO:0010894)	2.53294966
90	proteasome assembly (GO:0043248)	2.52870338
91	renal system process involved in regulation of blood volume (GO:0001977)	2.52341467
92	positive regulation of cGMP metabolic process (GO:0030825)	2.51512792
93	glutathione derivative biosynthetic process (GO:1901687)	2.51090962
94	glutathione derivative metabolic process (GO:1901685)	2.51090962
95	regulation of interleukin-8 secretion (GO:2000482)	2.50510932
96	regulation of keratinocyte differentiation (GO:0045616)	2.49825205
97	regulation of cellular amino acid metabolic process (GO:0006521)	2.49576759
98	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.47870723
99	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.47569176
100	regulation of systemic arterial blood pressure (GO:0003073)	2.46431535

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.38242368
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.77929550
3	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.32898011
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.08505286
5	ZNF263_19887448_ChIP-Seq_K562_Human	2.65839198
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.61714350
7	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.52720777
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.49960282
9	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.49863374
10	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.45282284
11	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.44234703
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.43822149
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31853924
14	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.26717588
15	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.19378691
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.12864423
17	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.11119140
18	AR_21909140_ChIP-Seq_LNCAP_Human	2.04403922
19	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.00980925
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.00045070
21	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.96677766
22	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.89330581
23	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.87835976
24	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.81612517
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.78333618
26	GATA4_25053715_ChIP-Seq_YYC3_Human	1.77837025
27	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.77020692
28	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74784537
29	GATA6_25053715_ChIP-Seq_YYC3_Human	1.73741536
30	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.70514345
31	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.68343909
32	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.67431067
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.64072074
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.61882012
35	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.60086194
36	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.57635231
37	ATF3_27146783_Chip-Seq_COLON_Human	1.51934605
38	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51339265
39	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.50697403
40	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.49576385
41	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.48476571
42	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.48321600
43	SOX2_20726797_ChIP-Seq_SW620_Human	1.45490353
44	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.44208632
45	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.43215387
46	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.40550732
47	CLOCK_20551151_ChIP-Seq_293T_Human	1.40341638
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.40063276
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32483892
50	LXR_22292898_ChIP-Seq_THP-1_Human	1.32129223
51	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.30853349
52	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.30725875
53	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.29378441
54	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.28466315
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27379703
56	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.26565905
57	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.26544430
58	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.26093690
59	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.26019799
60	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.25279941
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.24803577
62	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.23204333
63	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.22255526
64	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.21548602
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.17352090
66	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15662183
67	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.14602323
68	BCOR_27268052_Chip-Seq_Bcells_Human	1.14501856
69	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.13666956
70	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.13666956
71	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.11216752
72	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.10307913
73	XRN2_22483619_ChIP-Seq_HELA_Human	1.09050738
74	BCL6_27268052_Chip-Seq_Bcells_Human	1.06470706
75	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.05017117
76	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.04959363
77	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.02602315
78	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.02103211
79	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.01714346
80	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.01430041
81	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.01217172
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.99749042
83	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.99039325
84	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.98273103
85	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.98111631
86	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.97718777
87	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.97190772
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96225804
89	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.94358301
90	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.93963191
91	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.93091077
92	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92046275
93	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91661328
94	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.91405124
95	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.91304517
96	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.91203201
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.91172256
98	SA1_27219007_Chip-Seq_Bcells_Human	0.91097304
99	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.90250754
100	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.89139424

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.61344190
2	MP0005451_abnormal_body_composition	5.49541432
3	MP0001666_abnormal_nutrient_absorption	3.63197929
4	MP0010234_abnormal_vibrissa_follicle	3.51553396
5	MP0000013_abnormal_adipose_tissue	2.91902934
6	MP0010352_gastrointestinal_tract_polyps	2.91246517
7	MP0003011_delayed_dark_adaptation	2.78860192
8	MP0000537_abnormal_urethra_morphology	2.72468975
9	MP0004019_abnormal_vitamin_homeostasis	2.60077699
10	MP0010030_abnormal_orbit_morphology	2.46798124
11	MP0008438_abnormal_cutaneous_collagen	2.43705393
12	MP0009840_abnormal_foam_cell	2.32511793
13	MP0008260_abnormal_autophagy	2.31104008
14	MP0003950_abnormal_plasma_membrane	2.10159997
15	MP0000538_abnormal_urinary_bladder	2.09551008
16	MP0005409_darkened_coat_color	2.05910010
17	MP0002139_abnormal_hepatobiliary_system	2.05835598
18	MP0005365_abnormal_bile_salt	2.01327022
19	MP0004272_abnormal_basement_membrane	1.98663303
20	MP0003315_abnormal_perineum_morphology	1.88172605
21	MP0005085_abnormal_gallbladder_physiolo	1.84853617
22	MP0009053_abnormal_anal_canal	1.83077878
23	MP0004264_abnormal_extraembryonic_tissu	1.82925857
24	MP0001873_stomach_inflammation	1.80565193
25	MP0003693_abnormal_embryo_hatching	1.80439054
26	MP0002796_impaired_skin_barrier	1.73936539
27	MP0008875_abnormal_xenobiotic_pharmacok	1.66271581
28	MP0005623_abnormal_meninges_morphology	1.63445063
29	MP0009379_abnormal_foot_pigmentation	1.54197259
30	MP0000490_abnormal_crypts_of	1.53965889
31	MP0003566_abnormal_cell_adhesion	1.53915990
32	MP0003718_maternal_effect	1.47190355
33	MP0006054_spinal_hemorrhage	1.46326337
34	MP0002282_abnormal_trachea_morphology	1.45668588
35	MP0003806_abnormal_nucleotide_metabolis	1.40479011
36	MP0000462_abnormal_digestive_system	1.39516672
37	MP0010155_abnormal_intestine_physiology	1.37888713
38	MP0001879_abnormal_lymphatic_vessel	1.33892892
39	MP0005058_abnormal_lysosome_morphology	1.32624222
40	MP0002098_abnormal_vibrissa_morphology	1.29821809
41	MP0005501_abnormal_skin_physiology	1.26988314
42	MP0010386_abnormal_urinary_bladder	1.26874674
43	MP0005023_abnormal_wound_healing	1.25945176
44	MP0000477_abnormal_intestine_morphology	1.20746963
45	MP0003279_aneurysm	1.19129070
46	MP0010368_abnormal_lymphatic_system	1.18805564
47	MP0004858_abnormal_nervous_system	1.18099758
48	MP0000003_abnormal_adipose_tissue	1.17181895
49	MP0001664_abnormal_digestion	1.16613022
50	MP0002295_abnormal_pulmonary_circulatio	1.15563295
51	MP0005165_increased_susceptibility_to	1.13248799
52	MP0000516_abnormal_urinary_system	1.11552684
53	MP0005367_renal/urinary_system_phenotyp	1.11552684
54	MP0004957_abnormal_blastocyst_morpholog	1.10694844
55	MP0005166_decreased_susceptibility_to	1.08263085
56	MP0000762_abnormal_tongue_morphology	1.04852048
57	MP0008004_abnormal_stomach_pH	1.02874933
58	MP0000467_abnormal_esophagus_morphology	1.02735937
59	MP0003453_abnormal_keratinocyte_physiol	1.02403431
60	MP0003705_abnormal_hypodermis_morpholog	1.01070021
61	MP0002166_altered_tumor_susceptibility	0.99488603
62	MP0005670_abnormal_white_adipose	0.97973996
63	MP0003191_abnormal_cellular_cholesterol	0.96505746
64	MP0001661_extended_life_span	0.96388707
65	MP0009643_abnormal_urine_homeostasis	0.95377488
66	MP0005332_abnormal_amino_acid	0.94200973
67	MP0010329_abnormal_lipoprotein_level	0.90036264
68	MP0001216_abnormal_epidermal_layer	0.88595990
69	MP0003183_abnormal_peptide_metabolism	0.87640505
70	MP0002160_abnormal_reproductive_system	0.87614086
71	MP0002060_abnormal_skin_morphology	0.85408015
72	MP0001485_abnormal_pinna_reflex	0.82586890
73	MP0001849_ear_inflammation	0.80865657
74	MP0002877_abnormal_melanocyte_morpholog	0.80801700
75	MP0005319_abnormal_enzyme/_coenzyme	0.80430628
76	MP0001881_abnormal_mammary_gland	0.79391418
77	MP0000678_abnormal_parathyroid_gland	0.79291459
78	MP0003283_abnormal_digestive_organ	0.77431472
79	MP0005330_cardiomyopathy	0.74756241
80	MP0009697_abnormal_copulation	0.74142464
81	MP0005595_abnormal_vascular_smooth	0.73153677
82	MP0003866_abnormal_defecation	0.72650585
83	MP0002006_tumorigenesis	0.71254658
84	MP0005584_abnormal_enzyme/coenzyme_acti	0.70120151
85	MP0005187_abnormal_penis_morphology	0.68982357
86	MP0008775_abnormal_heart_ventricle	0.68796031
87	MP0000465_gastrointestinal_hemorrhage	0.68396306
88	MP0002138_abnormal_hepatobiliary_system	0.67128657
89	MP0005395_other_phenotype	0.66270023
90	MP0003252_abnormal_bile_duct	0.63865570
91	MP0003879_abnormal_hair_cell	0.63386959
92	MP0000749_muscle_degeneration	0.62661207
93	MP0001765_abnormal_ion_homeostasis	0.61383980
94	MP0001756_abnormal_urination	0.61366077
95	MP0008872_abnormal_physiological_respon	0.61339322
96	MP0005164_abnormal_response_to	0.57796370
97	MP0000858_altered_metastatic_potential	0.57410470
98	MP0005375_adipose_tissue_phenotype	0.57409345
99	MP0004233_abnormal_muscle_weight	0.56006887
100	MP0001764_abnormal_homeostasis	0.55489104

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.34565841
2	Malnutrition (HP:0004395)	4.17778307
3	Premature rupture of membranes (HP:0001788)	3.90952858
4	Hydroxyprolinuria (HP:0003080)	3.63410739
5	Abnormality of proline metabolism (HP:0010907)	3.63410739
6	Confusion (HP:0001289)	3.33799795
7	Hypobetalipoproteinemia (HP:0003563)	3.23412710
8	Hypolipoproteinemia (HP:0010981)	3.10470521
9	Reduced subcutaneous adipose tissue (HP:0003758)	3.10018002
10	Aortic dissection (HP:0002647)	3.09852479
11	Renal tubular acidosis (HP:0001947)	3.08909299
12	Right ventricular cardiomyopathy (HP:0011663)	2.92248060
13	Osteolytic defects of the hand bones (HP:0009699)	2.77494088
14	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.77494088
15	Abnormality of the distal phalanges of the toes (HP:0010182)	2.75334463
16	Vascular calcification (HP:0004934)	2.65440893
17	B lymphocytopenia (HP:0010976)	2.63995874
18	Fat malabsorption (HP:0002630)	2.63784222
19	Proximal tubulopathy (HP:0000114)	2.63775920
20	Interstitial pulmonary disease (HP:0006530)	2.60698497
21	Nausea (HP:0002018)	2.58011941
22	Abnormality of pyrimidine metabolism (HP:0004353)	2.57927431
23	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.57822619
24	Cardiovascular calcification (HP:0011915)	2.57342653
25	Distal upper limb amyotrophy (HP:0007149)	2.56941802
26	Upper limb amyotrophy (HP:0009129)	2.56941802
27	Hypoalphalipoproteinemia (HP:0003233)	2.55920756
28	Hyperammonemia (HP:0001987)	2.46845493
29	Hand muscle atrophy (HP:0009130)	2.41414323
30	Ileus (HP:0002595)	2.36043461
31	Xanthomatosis (HP:0000991)	2.35885636
32	Alkalosis (HP:0001948)	2.34381736
33	Abnormality of B cell number (HP:0010975)	2.32835289
34	Congenital sensorineural hearing impairment (HP:0008527)	2.32606978
35	Pigmentary retinal degeneration (HP:0001146)	2.31955808
36	Lethargy (HP:0001254)	2.31419443
37	Renal duplication (HP:0000075)	2.30414968
38	Rough bone trabeculation (HP:0100670)	2.28087254
39	Hyperuricemia (HP:0002149)	2.27753416
40	Increased purine levels (HP:0004368)	2.27753416
41	Ureteral duplication (HP:0000073)	2.27374325
42	Steatorrhea (HP:0002570)	2.20726067
43	Abnormality of urine glucose concentration (HP:0011016)	2.20072562
44	Glycosuria (HP:0003076)	2.20072562
45	Short nail (HP:0001799)	2.18503840
46	Renal tubular dysfunction (HP:0000124)	2.16695599
47	Aortic aneurysm (HP:0004942)	2.16399225
48	Reduced antithrombin III activity (HP:0001976)	2.15772955
49	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.12020374
50	Systemic lupus erythematosus (HP:0002725)	2.11827062
51	Abnormal trabecular bone morphology (HP:0100671)	2.09646647
52	Abnormality of nucleobase metabolism (HP:0010932)	2.09195390
53	Increased serum pyruvate (HP:0003542)	2.06465626
54	Abnormality of glycolysis (HP:0004366)	2.06436202
55	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.05896392
56	Vacuolated lymphocytes (HP:0001922)	2.04749687
57	Hemorrhage of the eye (HP:0011885)	2.02589654
58	Acanthosis nigricans (HP:0000956)	2.01414783
59	Hyperalaninemia (HP:0003348)	1.97910489
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97910489
61	Abnormality of alanine metabolism (HP:0010916)	1.97910489
62	Chronic diarrhea (HP:0002028)	1.97304321
63	Bifid tongue (HP:0010297)	1.95214521
64	Ulnar bowing (HP:0003031)	1.94886707
65	Elbow flexion contracture (HP:0002987)	1.93330091
66	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.91320670
67	Cholecystitis (HP:0001082)	1.89840512
68	Abnormal gallbladder physiology (HP:0012438)	1.89840512
69	Esophageal neoplasm (HP:0100751)	1.87392689
70	Neoplasm of head and neck (HP:0012288)	1.87392689
71	Flat capital femoral epiphysis (HP:0003370)	1.87217468
72	Hyperparathyroidism (HP:0000843)	1.86884632
73	Abnormality of purine metabolism (HP:0004352)	1.86859871
74	Insulin resistance (HP:0000855)	1.86285247
75	Abnormality of the umbilical cord (HP:0010881)	1.85907934
76	Type I transferrin isoform profile (HP:0003642)	1.85618603
77	Prolonged neonatal jaundice (HP:0006579)	1.85370732
78	Vascular tortuosity (HP:0004948)	1.84831775
79	Dicarboxylic aciduria (HP:0003215)	1.82028157
80	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.82028157
81	Axonal loss (HP:0003447)	1.80960444
82	Abnormality of vitamin B metabolism (HP:0004340)	1.80035387
83	Hyperphosphaturia (HP:0003109)	1.79759296
84	Abnormality of carpal bone ossification (HP:0006257)	1.78220095
85	Glucose intolerance (HP:0000833)	1.78090553
86	Opisthotonus (HP:0002179)	1.77201680
87	Generalized amyotrophy (HP:0003700)	1.76695465
88	Long palpebral fissure (HP:0000637)	1.76312184
89	Mesomelia (HP:0003027)	1.75819276
90	Decreased subcutaneous fat (HP:0001002)	1.75799344
91	Stenosis of the external auditory canal (HP:0000402)	1.73274607
92	Severe visual impairment (HP:0001141)	1.72965552
93	Abnormality of serum amino acid levels (HP:0003112)	1.72934886
94	Abnormality of the Achilles tendon (HP:0005109)	1.72412160
95	Abnormalities of placenta or umbilical cord (HP:0001194)	1.72294346
96	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.72290384
97	Short middle phalanx of the 5th finger (HP:0004220)	1.72027727
98	Hypertriglyceridemia (HP:0002155)	1.71677759
99	Abnormality of vitamin metabolism (HP:0100508)	1.71506202
100	Hyperglycemia (HP:0003074)	1.69957796

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.33889815
2	TESK1	3.56171633
3	MST1R	3.54087146
4	TLK1	3.26912802
5	ERN1	3.01448476
6	ZAK	3.00964237
7	BUB1	2.95283625
8	PDK2	2.90623245
9	EPHB2	2.90424167
10	NME2	2.88206419
11	PBK	2.67953028
12	MYLK	2.55636774
13	PAK4	2.24950918
14	NEK1	2.01862675
15	SMG1	2.01693485
16	LMTK2	1.95146519
17	MAP3K12	1.93062853
18	LIMK1	1.91551455
19	TESK2	1.85168191
20	VRK2	1.69962136
21	MET	1.55211611
22	PRKD3	1.54113916
23	IRAK3	1.44081725
24	VRK1	1.42040639
25	PTK6	1.38500084
26	CDK9	1.37977499
27	TSSK6	1.34292345
28	CDK8	1.33271523
29	KDR	1.30498850
30	MAP3K3	1.28727761
31	DAPK3	1.26254198
32	PRKG2	1.25291107
33	RPS6KB2	1.22852459
34	FGFR4	1.21784843
35	PTK2	1.20496060
36	STK39	1.17879247
37	EPHB1	1.13970544
38	EIF2AK1	1.12483194
39	RPS6KA5	1.06399520
40	AURKA	1.02074122
41	ACVR1B	0.98547180
42	TBK1	0.97788749
43	LATS1	0.95429540
44	FER	0.94953680
45	AKT2	0.94850642
46	LATS2	0.93750743
47	MAP2K2	0.86451315
48	AURKB	0.82554738
49	MAP3K1	0.82502921
50	BCKDK	0.80555127
51	ILK	0.76688949
52	ABL2	0.75975058
53	DAPK1	0.74618650
54	CAMK2G	0.72273771
55	PIM2	0.71501798
56	CSNK1G3	0.71399165
57	MST4	0.71166077
58	CSNK1A1L	0.70692580
59	PAK1	0.70691667
60	NME1	0.69868333
61	MAP3K11	0.68327675
62	GRK6	0.67968693
63	MELK	0.65950241
64	ERBB4	0.65062630
65	SCYL2	0.64976506
66	EPHA4	0.64666992
67	ARAF	0.64337002
68	BRSK1	0.63749319
69	MAP2K7	0.63078428
70	STK16	0.62225608
71	PRKD2	0.57994022
72	PAK2	0.56497443
73	EIF2AK3	0.52981071
74	GSK3A	0.52560971
75	MAP3K8	0.52492764
76	OXSR1	0.51794542
77	CAMK2D	0.51156307
78	MAP2K1	0.48241205
79	ROCK1	0.45175159
80	CDK4	0.44589826
81	CDK7	0.44507217
82	WEE1	0.44157862
83	TTK	0.42651002
84	TAF1	0.41548069
85	MAPK11	0.41362192
86	PLK1	0.39724603
87	CAMK2B	0.39657262
88	GRK1	0.39637898
89	TTN	0.38940320
90	CSNK1G1	0.36550742
91	STK4	0.35442405
92	MAPK15	0.32007216
93	PRKCD	0.31846643
94	STK38	0.31332948
95	BMX	0.29116301
96	MAPKAPK5	0.26753391
97	PRKCA	0.26338673
98	ICK	0.26130827
99	CDC7	0.25967308
100	TAOK2	0.22707419

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fat digestion and absorption_Homo sapiens_hsa04975	3.68656441
2	Sulfur relay system_Homo sapiens_hsa04122	3.58891195
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.56915544
4	Proteasome_Homo sapiens_hsa03050	3.23222115
5	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.07111032
6	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.01396815
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.94011813
8	Sulfur metabolism_Homo sapiens_hsa00920	2.54293699
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.38329613
10	Glutathione metabolism_Homo sapiens_hsa00480	2.34253846
11	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.30702168
12	Renin-angiotensin system_Homo sapiens_hsa04614	2.23748883
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.12713732
14	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.04965970
15	Folate biosynthesis_Homo sapiens_hsa00790	1.99393523
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.89201813
17	Galactose metabolism_Homo sapiens_hsa00052	1.85694254
18	Pentose phosphate pathway_Homo sapiens_hsa00030	1.78631148
19	Mineral absorption_Homo sapiens_hsa04978	1.77068104
20	Protein digestion and absorption_Homo sapiens_hsa04974	1.72038334
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.64554263
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.64488434
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.55998276
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.55374788
25	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.50954858
26	Histidine metabolism_Homo sapiens_hsa00340	1.49807931
27	Carbon metabolism_Homo sapiens_hsa01200	1.41666337
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.41022516
29	Sphingolipid metabolism_Homo sapiens_hsa00600	1.40568698
30	Alcoholism_Homo sapiens_hsa05034	1.37576089
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.36027480
32	DNA replication_Homo sapiens_hsa03030	1.32208240
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31892952
34	Other glycan degradation_Homo sapiens_hsa00511	1.26330282
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.13292250
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12445763
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11629854
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10578736
39	Pancreatic secretion_Homo sapiens_hsa04972	1.06692845
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05187825
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02992360
42	PPAR signaling pathway_Homo sapiens_hsa03320	1.02651035
43	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.99690284
44	Bile secretion_Homo sapiens_hsa04976	0.99172618
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98324182
46	Vibrio cholerae infection_Homo sapiens_hsa05110	0.95616045
47	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.94671258
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.92682543
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92440390
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.90852447
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90538534
52	Fatty acid degradation_Homo sapiens_hsa00071	0.90316033
53	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.90294375
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89354648
55	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.87521545
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.82834611
57	Retinol metabolism_Homo sapiens_hsa00830	0.76993732
58	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.74863686
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74444210
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73902974
61	Purine metabolism_Homo sapiens_hsa00230	0.72247009
62	RNA polymerase_Homo sapiens_hsa03020	0.72024836
63	Caffeine metabolism_Homo sapiens_hsa00232	0.68642197
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63917266
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.63802696
66	Metabolic pathways_Homo sapiens_hsa01100	0.63792242
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.60031636
68	Fatty acid elongation_Homo sapiens_hsa00062	0.58189155
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.58184013
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57178150
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55642198
72	Complement and coagulation cascades_Homo sapiens_hsa04610	0.51510006
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48519602
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.48170140
75	Viral carcinogenesis_Homo sapiens_hsa05203	0.46789759
76	Parkinsons disease_Homo sapiens_hsa05012	0.42393626
77	Mismatch repair_Homo sapiens_hsa03430	0.42291282
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41851553
79	Peroxisome_Homo sapiens_hsa04146	0.40705367
80	Ribosome_Homo sapiens_hsa03010	0.39630783
81	Oxidative phosphorylation_Homo sapiens_hsa00190	0.38578525
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.38214028
83	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.37581319
84	Antigen processing and presentation_Homo sapiens_hsa04612	0.37403887
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36892758
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36333064
87	Base excision repair_Homo sapiens_hsa03410	0.35405029
88	Alzheimers disease_Homo sapiens_hsa05010	0.32780814
89	Huntingtons disease_Homo sapiens_hsa05016	0.32770931
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.32096110
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31772490
92	Tight junction_Homo sapiens_hsa04530	0.30628766
93	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.24787743
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.18537479
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.18375845
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.17888779
97	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.13496156
98	ECM-receptor interaction_Homo sapiens_hsa04512	0.12052605
99	HTLV-I infection_Homo sapiens_hsa05166	0.09220281
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.08921429

KRT8P47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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