ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	icosanoid biosynthetic process (GO:0046456)	9.15036486
2	fatty acid derivative biosynthetic process (GO:1901570)	9.15036486
3	cysteine metabolic process (GO:0006534)	9.14872695
4	bundle of His cell to Purkinje myocyte communication (GO:0086069)	8.72580026
5	glutathione metabolic process (GO:0006749)	8.69022244
6	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	8.00677814
7	unsaturated fatty acid biosynthetic process (GO:0006636)	7.81375458
8	mitochondrial calcium ion transport (GO:0006851)	5.53250754
9	regulation of protein kinase A signaling (GO:0010738)	5.52229847
10	glutathione biosynthetic process (GO:0006750)	5.00456179
11	mitochondrion distribution (GO:0048311)	4.89810467
12	nonribosomal peptide biosynthetic process (GO:0019184)	4.66928863
13	peptide catabolic process (GO:0043171)	4.66851703
14	fatty acid derivative metabolic process (GO:1901568)	4.64244028
15	icosanoid metabolic process (GO:0006690)	4.64244028
16	glutathione derivative metabolic process (GO:1901685)	4.37302909
17	glutathione derivative biosynthetic process (GO:1901687)	4.37302909
18	detection of light stimulus involved in sensory perception (GO:0050962)	4.24846190
19	detection of light stimulus involved in visual perception (GO:0050908)	4.24846190
20	unsaturated fatty acid metabolic process (GO:0033559)	4.19611328
21	fatty acid biosynthetic process (GO:0006633)	4.12566060
22	establishment of protein localization to Golgi (GO:0072600)	4.07761317
23	peptide metabolic process (GO:0006518)	4.07420251
24	protein targeting to Golgi (GO:0000042)	3.98995379
25	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.92841056
26	protein ADP-ribosylation (GO:0006471)	3.91572478
27	cyclic nucleotide catabolic process (GO:0009214)	3.81811542
28	serine family amino acid biosynthetic process (GO:0009070)	3.80550422
29	cAMP catabolic process (GO:0006198)	3.68443452
30	peptide biosynthetic process (GO:0043043)	3.52633467
31	xenobiotic catabolic process (GO:0042178)	3.52183210
32	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.38248587
33	glutamate metabolic process (GO:0006536)	3.37640224
34	regulation of metalloenzyme activity (GO:0048552)	3.35984517
35	protein localization to Golgi apparatus (GO:0034067)	3.34654933
36	detection of molecule of bacterial origin (GO:0032490)	3.33085517
37	GTP biosynthetic process (GO:0006183)	3.32271080
38	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.27815041
39	membrane depolarization during action potential (GO:0086010)	3.22161840
40	cell communication involved in cardiac conduction (GO:0086065)	3.17448985
41	regulation of hexokinase activity (GO:1903299)	3.12006799
42	regulation of glucokinase activity (GO:0033131)	3.12006799
43	positive regulation of actin filament depolymerization (GO:0030836)	3.05799294
44	myelin assembly (GO:0032288)	3.04268787
45	cellular modified amino acid catabolic process (GO:0042219)	3.02985562
46	proteasome assembly (GO:0043248)	3.02244710
47	artery smooth muscle contraction (GO:0014824)	2.98188082
48	hepatocyte apoptotic process (GO:0097284)	2.95740332
49	androgen biosynthetic process (GO:0006702)	2.88276225
50	prenylation (GO:0097354)	2.84402459
51	protein prenylation (GO:0018342)	2.84402459
52	neuronal action potential (GO:0019228)	2.83883602
53	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.83765048
54	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.83765048
55	protein maturation by protein folding (GO:0022417)	2.80606577
56	serine family amino acid metabolic process (GO:0009069)	2.79535743
57	UTP biosynthetic process (GO:0006228)	2.77978105
58	microglial cell activation (GO:0001774)	2.72548218
59	membrane budding (GO:0006900)	2.70828059
60	cellular amide metabolic process (GO:0043603)	2.68989297
61	fatty acid elongation (GO:0030497)	2.67551905
62	monocarboxylic acid biosynthetic process (GO:0072330)	2.67150466
63	sulfur amino acid biosynthetic process (GO:0000097)	2.66282835
64	somite rostral/caudal axis specification (GO:0032525)	2.65666963
65	viral mRNA export from host cell nucleus (GO:0046784)	2.61557611
66	regulation of cilium movement (GO:0003352)	2.58242833
67	positive regulation of mRNA processing (GO:0050685)	2.55436592
68	peristalsis (GO:0030432)	2.54874802
69	spliceosomal snRNP assembly (GO:0000387)	2.54567195
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.54557796
71	regulation of cofactor metabolic process (GO:0051193)	2.51972717
72	regulation of coenzyme metabolic process (GO:0051196)	2.51972717
73	phasic smooth muscle contraction (GO:0014821)	2.51593798
74	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.51286514
75	glycine transport (GO:0015816)	2.49620699
76	multicellular organism reproduction (GO:0032504)	2.49477634
77	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.49440936
78	regulation of sulfur metabolic process (GO:0042762)	2.45845179
79	establishment of integrated proviral latency (GO:0075713)	2.44829403
80	regulation of mRNA 3-end processing (GO:0031440)	2.41943770
81	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.39654748
82	tonic smooth muscle contraction (GO:0014820)	2.38527686
83	guanosine-containing compound biosynthetic process (GO:1901070)	2.37866659
84	signal peptide processing (GO:0006465)	2.35310952
85	response to nitrosative stress (GO:0051409)	2.34396433
86	cGMP metabolic process (GO:0046068)	2.32971229
87	cellular modified amino acid metabolic process (GO:0006575)	2.31835294
88	UTP metabolic process (GO:0046051)	2.31596337
89	CTP biosynthetic process (GO:0006241)	2.31216465
90	CTP metabolic process (GO:0046036)	2.31216465
91	regulation of cardiac muscle contraction (GO:0055117)	2.30785588
92	nucleoside transmembrane transport (GO:1901642)	2.30215545
93	calcium ion import (GO:0070509)	2.30013436
94	cobalamin metabolic process (GO:0009235)	2.28002488
95	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.27543287
96	response to gravity (GO:0009629)	2.27368288
97	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.25904799
98	inositol phosphate dephosphorylation (GO:0046855)	2.25904799
99	leukotriene biosynthetic process (GO:0019370)	15.6862023
100	leukotriene metabolic process (GO:0006691)	10.2180549

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.88493148
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.39246527
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.10563630
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.82695939
5	IRF1_19129219_ChIP-ChIP_H3396_Human	2.82213678
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58086135
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55699994
8	VDR_22108803_ChIP-Seq_LS180_Human	2.41385339
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.33609850
10	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.18994546
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16247583
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.11556706
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09179216
14	P300_19829295_ChIP-Seq_ESCs_Human	2.05724148
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.05600638
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.05013924
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97622809
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.90401028
19	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.85833444
20	FUS_26573619_Chip-Seq_HEK293_Human	1.81504108
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81371048
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.80460087
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77910971
24	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.75500246
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66885714
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63580103
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.62735916
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.62621497
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60878071
30	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.56900596
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.55883842
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51571631
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50988659
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44424094
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43797222
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.43797222
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.42999551
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38049360
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37137741
40	CDX2_22108803_ChIP-Seq_LS180_Human	1.36221351
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.33782632
42	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.32733518
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.31193344
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31178291
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29435203
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28511379
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28136117
48	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.27785311
49	EWS_26573619_Chip-Seq_HEK293_Human	1.27095656
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.26019684
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25323195
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25128339
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24691097
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.24296038
55	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.22754078
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.18618440
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18486574
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15247529
59	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15205222
60	GATA4_25053715_ChIP-Seq_YYC3_Human	1.15093448
61	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14934558
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14014263
63	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.13456242
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.12330058
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10875214
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10130396
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10000732
68	CJUN_26792858_Chip-Seq_BT549_Human	1.09447122
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08231469
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07356408
71	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.06594866
72	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06055665
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05832600
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05832600
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05060481
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03646271
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03484038
78	AR_25329375_ChIP-Seq_VCAP_Human	1.03054032
79	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.02180969
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01985511
81	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00479404
82	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.99627929
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.99352223
84	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98442669
85	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.96814320
86	CBP_21632823_ChIP-Seq_H3396_Human	0.95284080
87	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.95135803
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93553267
89	DCP1A_22483619_ChIP-Seq_HELA_Human	0.91939999
90	STAT3_23295773_ChIP-Seq_U87_Human	0.91121143
91	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.90889581
92	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90096225
93	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.88649173
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88557289
95	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.88330626
96	AR_20517297_ChIP-Seq_VCAP_Human	0.87990168
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.87697530
98	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.86556988
99	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.86141235
100	GATA6_25053715_ChIP-Seq_YYC3_Human	0.83473914

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	5.43449415
2	MP0002736_abnormal_nociception_after	5.13628632
3	MP0005379_endocrine/exocrine_gland_phen	4.15270598
4	MP0003183_abnormal_peptide_metabolism	4.09639860
5	MP0002822_catalepsy	3.78801419
6	MP0000613_abnormal_salivary_gland	3.47888351
7	MP0001968_abnormal_touch/_nociception	3.40349975
8	MP0003195_calcinosis	3.34769378
9	MP0005220_abnormal_exocrine_pancreas	3.23728813
10	MP0006054_spinal_hemorrhage	2.36628914
11	MP0005084_abnormal_gallbladder_morpholo	2.33138343
12	MP0002089_abnormal_postnatal_growth/wei	2.32726533
13	MP0002102_abnormal_ear_morphology	2.18212993
14	MP0002138_abnormal_hepatobiliary_system	2.07571602
15	MP0008260_abnormal_autophagy	2.06538201
16	MP0000647_abnormal_sebaceous_gland	2.04039073
17	MP0008875_abnormal_xenobiotic_pharmacok	2.00012213
18	MP0001529_abnormal_vocalization	1.99851330
19	MP0005551_abnormal_eye_electrophysiolog	1.91986631
20	MP0008877_abnormal_DNA_methylation	1.85743206
21	MP0003693_abnormal_embryo_hatching	1.82430443
22	MP0003786_premature_aging	1.78024765
23	MP0008872_abnormal_physiological_respon	1.62955216
24	MP0000569_abnormal_digit_pigmentation	1.62896754
25	MP0005365_abnormal_bile_salt	1.53930780
26	MP0000383_abnormal_hair_follicle	1.48938138
27	MP0003252_abnormal_bile_duct	1.47611475
28	MP0003950_abnormal_plasma_membrane	1.47172060
29	MP0006035_abnormal_mitochondrial_morpho	1.44396842
30	MP0002928_abnormal_bile_duct	1.43543331
31	MP0004019_abnormal_vitamin_homeostasis	1.41136806
32	MP0005584_abnormal_enzyme/coenzyme_acti	1.38060208
33	MP0004484_altered_response_of	1.37110989
34	MP0005332_abnormal_amino_acid	1.37015370
35	MP0002277_abnormal_respiratory_mucosa	1.30706222
36	MP0010678_abnormal_skin_adnexa	1.29325636
37	MP0002733_abnormal_thermal_nociception	1.27098212
38	MP0003943_abnormal_hepatobiliary_system	1.23652804
39	MP0005085_abnormal_gallbladder_physiolo	1.20535871
40	MP0004142_abnormal_muscle_tone	1.19968146
41	MP0001984_abnormal_olfaction	1.18374725
42	MP0005187_abnormal_penis_morphology	1.17078461
43	MP0003890_abnormal_embryonic-extraembry	1.17044665
44	MP0004147_increased_porphyrin_level	1.16140901
45	MP0008995_early_reproductive_senescence	1.11743361
46	MP0005360_urolithiasis	1.10284547
47	MP0000358_abnormal_cell_content/	1.08101583
48	MP0001666_abnormal_nutrient_absorption	1.07127268
49	MP0010386_abnormal_urinary_bladder	1.05133508
50	MP0002090_abnormal_vision	1.03632839
51	MP0008058_abnormal_DNA_repair	1.01005886
52	MP0008775_abnormal_heart_ventricle	0.98522283
53	MP0001905_abnormal_dopamine_level	0.97530272
54	MP0000371_diluted_coat_color	0.95786999
55	MP0001944_abnormal_pancreas_morphology	0.94756437
56	MP0006072_abnormal_retinal_apoptosis	0.93987512
57	MP0006036_abnormal_mitochondrial_physio	0.93986808
58	MP0001756_abnormal_urination	0.91055008
59	MP0010234_abnormal_vibrissa_follicle	0.89261625
60	MP0002067_abnormal_sensory_capabilities	0.87160785
61	MP0004043_abnormal_pH_regulation	0.87087831
62	MP0000858_altered_metastatic_potential	0.83868918
63	MP0001970_abnormal_pain_threshold	0.83778858
64	MP0003186_abnormal_redox_activity	0.83456152
65	MP0004264_abnormal_extraembryonic_tissu	0.82741172
66	MP0005410_abnormal_fertilization	0.82200414
67	MP0005083_abnormal_biliary_tract	0.78497048
68	MP0008007_abnormal_cellular_replicative	0.76163871
69	MP0010094_abnormal_chromosome_stability	0.75303344
70	MP0010771_integument_phenotype	0.74416988
71	MP0002877_abnormal_melanocyte_morpholog	0.73513913
72	MP0009697_abnormal_copulation	0.73235542
73	MP0005253_abnormal_eye_physiology	0.72480834
74	MP0002229_neurodegeneration	0.71990263
75	MP0005408_hypopigmentation	0.70744173
76	MP0008004_abnormal_stomach_pH	0.69404463
77	MP0000427_abnormal_hair_cycle	0.68715701
78	MP0004957_abnormal_blastocyst_morpholog	0.67783632
79	MP0003718_maternal_effect	0.67352795
80	MP0005636_abnormal_mineral_homeostasis	0.67254513
81	MP0005319_abnormal_enzyme/_coenzyme	0.66025570
82	MP0002751_abnormal_autonomic_nervous	0.65720672
83	MP0003123_paternal_imprinting	0.65108010
84	MP0004133_heterotaxia	0.64820529
85	MP0000653_abnormal_sex_gland	0.64409573
86	MP0005670_abnormal_white_adipose	0.64197678
87	MP0001145_abnormal_male_reproductive	0.63815502
88	MP0002557_abnormal_social/conspecific_i	0.63690517
89	MP0004270_analgesia	0.61930550
90	MP0003119_abnormal_digestive_system	0.61780898
91	MP0005394_taste/olfaction_phenotype	0.60644220
92	MP0005499_abnormal_olfactory_system	0.60644220
93	MP0009046_muscle_twitch	0.60617513
94	MP0003567_abnormal_fetal_cardiomyocyte	0.59621844
95	MP0003315_abnormal_perineum_morphology	0.58034104
96	MP0002837_dystrophic_cardiac_calcinosis	0.57633634
97	MP0002272_abnormal_nervous_system	0.57301167
98	MP0002332_abnormal_exercise_endurance	0.56231349
99	MP0001764_abnormal_homeostasis	0.55743944
100	MP0000372_irregular_coat_pigmentation	0.55488509

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	7.38054248
2	Hypoplasia of the fovea (HP:0007750)	7.38054248
3	Severe visual impairment (HP:0001141)	7.32565676
4	Congenital stationary night blindness (HP:0007642)	6.65697047
5	Abnormality of the fovea (HP:0000493)	6.13381663
6	Central scotoma (HP:0000603)	5.64889688
7	Abnormality of macular pigmentation (HP:0008002)	5.54143989
8	Aplasia/Hypoplasia of the macula (HP:0008059)	5.07729330
9	Abnormal rod and cone electroretinograms (HP:0008323)	5.06268846
10	Aplasia/Hypoplasia affecting the retina (HP:0008061)	4.65805328
11	Albinism (HP:0001022)	4.51360856
12	J-shaped sella turcica (HP:0002680)	4.03986391
13	Abnormality of glycolipid metabolism (HP:0010969)	3.75080174
14	Abnormality of liposaccharide metabolism (HP:0010968)	3.75080174
15	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.75080174
16	Tongue fasciculations (HP:0001308)	3.34345909
17	Scotoma (HP:0000575)	3.27401221
18	Broad alveolar ridges (HP:0000187)	3.26291583
19	Carpal bone hypoplasia (HP:0001498)	3.13631989
20	Diastasis recti (HP:0001540)	2.93144879
21	Nausea (HP:0002018)	2.85867559
22	Muscle fibrillation (HP:0010546)	2.83875886
23	Generalized aminoaciduria (HP:0002909)	2.77149590
24	Vascular calcification (HP:0004934)	2.56318290
25	Hypoglycemic coma (HP:0001325)	2.54444059
26	Thoracolumbar scoliosis (HP:0002944)	2.44559806
27	Renal cortical cysts (HP:0000803)	2.33722239
28	Abnormality of the renal cortex (HP:0011035)	2.30358355
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29431692
30	Absent/shortened dynein arms (HP:0200106)	2.29431692
31	Deformed sella turcica (HP:0002681)	2.29426964
32	Proximal tubulopathy (HP:0000114)	2.29411276
33	Abnormality of the anterior horn cell (HP:0006802)	2.27656076
34	Degeneration of anterior horn cells (HP:0002398)	2.27656076
35	Hepatic necrosis (HP:0002605)	2.23210281
36	Generalized hypopigmentation (HP:0007513)	2.22800281
37	Abnormality of the sella turcica (HP:0002679)	2.19934857
38	Vertebral arch anomaly (HP:0008438)	2.18964862
39	Tubulointerstitial nephritis (HP:0001970)	2.12158708
40	Hand muscle atrophy (HP:0009130)	2.10703907
41	Nonprogressive disorder (HP:0003680)	2.09875482
42	Glycosuria (HP:0003076)	2.07640235
43	Abnormality of urine glucose concentration (HP:0011016)	2.07640235
44	Methylmalonic aciduria (HP:0012120)	2.06844774
45	Adrenal hypoplasia (HP:0000835)	2.06063661
46	Methylmalonic acidemia (HP:0002912)	2.03266339
47	Beaking of vertebral bodies (HP:0004568)	2.02488766
48	Cardiovascular calcification (HP:0011915)	2.02380706
49	True hermaphroditism (HP:0010459)	2.00887512
50	Hypoplastic scapulae (HP:0000882)	1.99682059
51	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.99682059
52	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.99192678
53	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.99192678
54	Abnormality of polysaccharide metabolism (HP:0011012)	1.99192678
55	Median cleft lip (HP:0000161)	1.99081839
56	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.97752612
57	Pancreatic cysts (HP:0001737)	1.95927283
58	Acute necrotizing encephalopathy (HP:0006965)	1.94577917
59	Hypoplasia of the uterus (HP:0000013)	1.94569215
60	Intrahepatic cholestasis (HP:0001406)	1.93896221
61	Abnormality of alanine metabolism (HP:0010916)	1.93137914
62	Hyperalaninemia (HP:0003348)	1.93137914
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93137914
64	Abnormality of the lumbar spine (HP:0100712)	1.92790451
65	Congenital, generalized hypertrichosis (HP:0004540)	1.86805222
66	Anomalous pulmonary venous return (HP:0010772)	1.85237033
67	Type I transferrin isoform profile (HP:0003642)	1.80865616
68	Postnatal microcephaly (HP:0005484)	1.79908719
69	Pancreatic fibrosis (HP:0100732)	1.79137857
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78157330
71	Glucose intolerance (HP:0000833)	1.76530614
72	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.76446608
73	Tubular atrophy (HP:0000092)	1.74388751
74	Acute encephalopathy (HP:0006846)	1.74203918
75	Urinary glycosaminoglycan excretion (HP:0003541)	1.70136404
76	Mucopolysacchariduria (HP:0008155)	1.70136404
77	Abnormality of glycolysis (HP:0004366)	1.68615480
78	Abnormal auditory evoked potentials (HP:0006958)	1.67959802
79	Increased serum pyruvate (HP:0003542)	1.67342261
80	Palpebral edema (HP:0100540)	1.66792687
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.66742347
82	Aplasia/hypoplasia of the uterus (HP:0008684)	1.63891812
83	Thoracic kyphosis (HP:0002942)	1.61065432
84	Progressive macrocephaly (HP:0004481)	1.60847279
85	Astigmatism (HP:0000483)	1.59071918
86	Double outlet right ventricle (HP:0001719)	1.58453406
87	Congenital malformation of the right heart (HP:0011723)	1.58453406
88	Abnormal spermatogenesis (HP:0008669)	1.58329809
89	Mitochondrial inheritance (HP:0001427)	1.57462066
90	Increased CSF lactate (HP:0002490)	1.56661917
91	Progressive inability to walk (HP:0002505)	1.56317399
92	Abnormality of methionine metabolism (HP:0010901)	1.52418926
93	Hypophosphatemic rickets (HP:0004912)	1.52370913
94	Broad-based gait (HP:0002136)	1.50525478
95	Hepatocellular necrosis (HP:0001404)	1.50182969
96	Male pseudohermaphroditism (HP:0000037)	1.48706201
97	Protuberant abdomen (HP:0001538)	1.48705806
98	Abnormality of the pulmonary veins (HP:0011718)	1.47886341
99	Attenuation of retinal blood vessels (HP:0007843)	1.47742219
100	Abnormality of the alveolar ridges (HP:0006477)	1.47050702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.88914825
2	BLK	3.73060858
3	EPHA2	3.27393163
4	LMTK2	3.22515356
5	MST4	2.85591242
6	PDK2	2.76718564
7	TLK1	2.47834752
8	BRD4	2.37818974
9	CSNK1A1L	2.33983985
10	ZAK	2.26436095
11	VRK2	2.25017657
12	BUB1	2.18813235
13	VRK1	2.18740234
14	MAP3K2	2.06026666
15	MAP4K2	2.04290320
16	CSNK1G3	1.94756986
17	PBK	1.94454626
18	ACVR1B	1.93324387
19	PTK2B	1.87573531
20	CAMKK2	1.72912664
21	CSNK1G2	1.70021657
22	CSNK1G1	1.67139401
23	TESK1	1.66298290
24	LIMK1	1.65109829
25	FER	1.56975493
26	MAP3K12	1.54062952
27	TNIK	1.46708505
28	TRIM28	1.43345011
29	GRK1	1.38239709
30	MET	1.34521578
31	MAP2K7	1.22656332
32	BCKDK	1.20291424
33	MAPK15	1.18916261
34	NTRK3	1.12368571
35	STK10	1.10951680
36	ADRBK2	1.08074281
37	TAF1	1.02345268
38	GRK5	1.01008268
39	MAP3K3	0.96968610
40	TESK2	0.94980658
41	PLK3	0.94519749
42	TSSK6	0.93772499
43	FGR	0.93099767
44	STK38L	0.92660488
45	OXSR1	0.91889785
46	PLK2	0.91785793
47	MAP3K5	0.91713318
48	CASK	0.91507938
49	NME2	0.89325035
50	CAMK2D	0.88345871
51	ERBB4	0.87911964
52	CDK19	0.85746334
53	NUAK1	0.83552488
54	DAPK1	0.79271841
55	INSRR	0.73485395
56	WNK3	0.68246161
57	BRSK1	0.67344457
58	BRSK2	0.66371790
59	TIE1	0.62612118
60	CAMK2B	0.62030328
61	YES1	0.60001315
62	ADRBK1	0.59434380
63	PAK3	0.55279574
64	RPS6KA5	0.54944531
65	BMPR1B	0.54880709
66	EIF2AK1	0.54816532
67	RPS6KA4	0.53937446
68	MST1R	0.53237502
69	CAMK2G	0.52649475
70	DYRK3	0.49834044
71	PHKG2	0.47401654
72	PHKG1	0.47401654
73	MAP3K4	0.46617212
74	EIF2AK3	0.46543936
75	PLK1	0.45666480
76	CAMK2A	0.43228728
77	PIK3CG	0.42525013
78	CSNK1A1	0.41271702
79	STK4	0.40794530
80	STK16	0.40097916
81	CAMK4	0.39219781
82	PRKCE	0.38991369
83	RPS6KB2	0.38329572
84	WEE1	0.37519271
85	MAP3K8	0.35979814
86	GRK7	0.35728239
87	ARAF	0.35397099
88	CDK9	0.34860918
89	MAPKAPK3	0.34442031
90	PRKD1	0.33177910
91	PRKG1	0.33001058
92	SIK3	0.32436446
93	AURKB	0.32388759
94	IRAK4	0.31827915
95	DAPK3	0.30717253
96	ROCK1	0.30414796
97	MAPK7	0.29525297
98	NEK1	0.29521965
99	PAK4	0.28846097
100	DAPK2	0.28690350

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	8.04924533
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.36367652
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.77730344
4	Proteasome_Homo sapiens_hsa03050	2.66932761
5	Fatty acid elongation_Homo sapiens_hsa00062	2.59406693
6	Glutathione metabolism_Homo sapiens_hsa00480	2.19747661
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.07763198
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.92319966
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75985710
10	Taste transduction_Homo sapiens_hsa04742	1.49046297
11	beta-Alanine metabolism_Homo sapiens_hsa00410	1.24314719
12	GABAergic synapse_Homo sapiens_hsa04727	1.22088760
13	Alcoholism_Homo sapiens_hsa05034	1.18561820
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.14730369
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13879475
16	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12022094
17	Propanoate metabolism_Homo sapiens_hsa00640	1.10421495
18	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09000383
19	Sulfur relay system_Homo sapiens_hsa04122	1.08338508
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.07660452
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.07279475
22	Morphine addiction_Homo sapiens_hsa05032	1.07147199
23	Mismatch repair_Homo sapiens_hsa03430	1.06712960
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.06185904
25	Parkinsons disease_Homo sapiens_hsa05012	1.03933963
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03234871
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02190901
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.01285084
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00552964
30	Nicotine addiction_Homo sapiens_hsa05033	0.98914881
31	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97378001
32	Fatty acid metabolism_Homo sapiens_hsa01212	0.97343781
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.97316468
34	Alzheimers disease_Homo sapiens_hsa05010	0.96885195
35	Serotonergic synapse_Homo sapiens_hsa04726	0.96849666
36	Homologous recombination_Homo sapiens_hsa03440	0.96267890
37	Pyruvate metabolism_Homo sapiens_hsa00620	0.93445318
38	Sulfur metabolism_Homo sapiens_hsa00920	0.91079466
39	Huntingtons disease_Homo sapiens_hsa05016	0.87563728
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87013438
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86098793
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84607029
43	Folate biosynthesis_Homo sapiens_hsa00790	0.82979388
44	Vibrio cholerae infection_Homo sapiens_hsa05110	0.81949382
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80835841
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77357475
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.76589577
48	Protein export_Homo sapiens_hsa03060	0.75657920
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75410369
50	Histidine metabolism_Homo sapiens_hsa00340	0.75304108
51	Peroxisome_Homo sapiens_hsa04146	0.73777839
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72828875
53	DNA replication_Homo sapiens_hsa03030	0.72467436
54	RNA transport_Homo sapiens_hsa03013	0.71748945
55	Spliceosome_Homo sapiens_hsa03040	0.70560636
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.69777828
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66377094
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.64129831
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.63817662
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.62876928
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62819947
62	Phototransduction_Homo sapiens_hsa04744	0.62380119
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62308381
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61697148
65	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.60251101
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60225824
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59600078
68	Purine metabolism_Homo sapiens_hsa00230	0.59438421
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58736961
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58382229
71	Metabolic pathways_Homo sapiens_hsa01100	0.58129941
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.57996945
73	Renin secretion_Homo sapiens_hsa04924	0.57624079
74	Fatty acid degradation_Homo sapiens_hsa00071	0.57395884
75	Regulation of autophagy_Homo sapiens_hsa04140	0.57053444
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56676641
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55086528
78	Carbon metabolism_Homo sapiens_hsa01200	0.53836929
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53276159
80	Caffeine metabolism_Homo sapiens_hsa00232	0.52618518
81	Basal transcription factors_Homo sapiens_hsa03022	0.52417835
82	Amphetamine addiction_Homo sapiens_hsa05031	0.50340728
83	Salivary secretion_Homo sapiens_hsa04970	0.49493173
84	Butanoate metabolism_Homo sapiens_hsa00650	0.49417255
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.48734184
86	Base excision repair_Homo sapiens_hsa03410	0.48180038
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.45502255
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44253423
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44044510
90	RNA polymerase_Homo sapiens_hsa03020	0.43746213
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43715987
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43588822
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43079629
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42920026
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41361363
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40561536
97	Galactose metabolism_Homo sapiens_hsa00052	0.39276732
98	Tight junction_Homo sapiens_hsa04530	0.39270571
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.38670963
100	Oocyte meiosis_Homo sapiens_hsa04114	0.38197334

KRT8P48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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