ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of guanylate cyclase activity (GO:0031282)	6.81772321
2	NADH metabolic process (GO:0006734)	6.40587933
3	antibacterial humoral response (GO:0019731)	6.14895663
4	antimicrobial humoral response (GO:0019730)	5.81916251
5	positive regulation of pseudopodium assembly (GO:0031274)	5.75619942
6	angiotensin maturation (GO:0002003)	5.50838655
7	positive regulation of guanylate cyclase activity (GO:0031284)	5.48208025
8	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	5.38790372
9	fructose metabolic process (GO:0006000)	5.28325831
10	regulation of pseudopodium assembly (GO:0031272)	5.10047081
11	GDP-mannose metabolic process (GO:0019673)	4.99660843
12	positive regulation of respiratory burst (GO:0060267)	4.95388491
13	epoxygenase P450 pathway (GO:0019373)	4.90059905
14	negative regulation of epidermal cell differentiation (GO:0045605)	4.82650092
15	regulation of cellular extravasation (GO:0002691)	4.78930815
16	intestinal absorption (GO:0050892)	4.77726852
17	digestion (GO:0007586)	4.31079180
18	eosinophil chemotaxis (GO:0048245)	4.23402855
19	vitamin transmembrane transport (GO:0035461)	4.21491952
20	homocysteine metabolic process (GO:0050667)	4.09092631
21	L-ascorbic acid metabolic process (GO:0019852)	4.06696497
22	negative regulation of epidermis development (GO:0045683)	4.03259395
23	regulation of cGMP biosynthetic process (GO:0030826)	3.99891158
24	regulation of respiratory burst (GO:0060263)	3.98844664
25	vitamin transport (GO:0051180)	3.95907108
26	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.90509668
27	endocrine process (GO:0050886)	3.90509668
28	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.90509668
29	xenobiotic catabolic process (GO:0042178)	3.84693408
30	artery smooth muscle contraction (GO:0014824)	3.79627516
31	regulation of systemic arterial blood pressure (GO:0003073)	3.77004826
32	vitamin A metabolic process (GO:0006776)	3.75149486
33	eosinophil migration (GO:0072677)	3.74122968
34	prostaglandin biosynthetic process (GO:0001516)	3.72202726
35	prostanoid biosynthetic process (GO:0046457)	3.72202726
36	prostanoid metabolic process (GO:0006692)	3.68498332
37	prostaglandin metabolic process (GO:0006693)	3.68498332
38	arginine metabolic process (GO:0006525)	3.63424922
39	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.62811241
40	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.62636806
41	polyketide metabolic process (GO:0030638)	3.62076751
42	doxorubicin metabolic process (GO:0044598)	3.62076751
43	daunorubicin metabolic process (GO:0044597)	3.62076751
44	renal system process involved in regulation of blood volume (GO:0001977)	3.61714713
45	glomerular filtration (GO:0003094)	3.61091544
46	nucleotide-sugar biosynthetic process (GO:0009226)	3.56794382
47	glutathione derivative metabolic process (GO:1901685)	3.55867618
48	glutathione derivative biosynthetic process (GO:1901687)	3.55867618
49	regulation of triglyceride catabolic process (GO:0010896)	3.52215698
50	nucleoside diphosphate biosynthetic process (GO:0009133)	3.50775027
51	cobalamin metabolic process (GO:0009235)	3.47218172
52	cyclooxygenase pathway (GO:0019371)	3.46747301
53	positive regulation of glycoprotein metabolic process (GO:1903020)	3.45903328
54	regulation of cGMP metabolic process (GO:0030823)	3.45704342
55	disruption of cells of other organism (GO:0044364)	3.42054449
56	killing of cells of other organism (GO:0031640)	3.42054449
57	drug metabolic process (GO:0017144)	3.41279129
58	fat-soluble vitamin biosynthetic process (GO:0042362)	3.39100117
59	monosaccharide catabolic process (GO:0046365)	3.37768594
60	auditory receptor cell differentiation (GO:0042491)	3.37380271
61	regulation of keratinocyte proliferation (GO:0010837)	3.35637488
62	glycoside metabolic process (GO:0016137)	3.35444752
63	renal filtration (GO:0097205)	3.32562874
64	regulation of bile acid biosynthetic process (GO:0070857)	3.32358272
65	aminoglycoside antibiotic metabolic process (GO:0030647)	3.32165466
66	chronic inflammatory response (GO:0002544)	3.27640275
67	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.27075280
68	glycolipid catabolic process (GO:0019377)	3.26958379
69	oligosaccharide biosynthetic process (GO:0009312)	3.24211033
70	tonic smooth muscle contraction (GO:0014820)	3.20930376
71	glucuronate metabolic process (GO:0019585)	3.17177668
72	uronic acid metabolic process (GO:0006063)	3.17177668
73	urea cycle (GO:0000050)	3.16628116
74	quinone biosynthetic process (GO:1901663)	3.15948546
75	hexose catabolic process (GO:0019320)	3.14689944
76	phosphate ion homeostasis (GO:0055062)	3.14549005
77	trivalent inorganic anion homeostasis (GO:0072506)	3.14549005
78	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.13402545
79	glutathione biosynthetic process (GO:0006750)	3.13137512
80	desmosome organization (GO:0002934)	3.11792091
81	fat-soluble vitamin metabolic process (GO:0006775)	3.11017191
82	defense response to fungus (GO:0050832)	3.10676268
83	regulation of keratinocyte differentiation (GO:0045616)	3.07945415
84	transepithelial transport (GO:0070633)	3.03670731
85	positive regulation of cGMP biosynthetic process (GO:0030828)	3.02608468
86	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.01742400
87	sulfation (GO:0051923)	3.01448754
88	urea metabolic process (GO:0019627)	2.99796296
89	complement activation, classical pathway (GO:0006958)	2.98199879
90	nonribosomal peptide biosynthetic process (GO:0019184)	2.97573623
91	regulation of gonadotropin secretion (GO:0032276)	2.96840564
92	quinone metabolic process (GO:1901661)	2.96051309
93	glutathione metabolic process (GO:0006749)	2.94471028
94	cellular glucuronidation (GO:0052695)	2.94403691
95	regulation of vitamin metabolic process (GO:0030656)	2.91432793
96	diaphragm development (GO:0060539)	2.90543096
97	virion attachment to host cell (GO:0019062)	2.87524323
98	adhesion of symbiont to host cell (GO:0044650)	2.87524323
99	sphingomyelin metabolic process (GO:0006684)	2.85539628
100	positive regulation of triglyceride metabolic process (GO:0090208)	2.84998231

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.02397714
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.27098255
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.86514549
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.85698870
5	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.79192319
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.09704024
7	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.05073297
8	GATA4_25053715_ChIP-Seq_YYC3_Human	2.91336692
9	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.89606189
10	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.81098807
11	GATA6_25053715_ChIP-Seq_YYC3_Human	2.78624576
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.68884952
13	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.52081093
14	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.44964710
15	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.18790544
16	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.17660603
17	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.15885418
18	SOX2_20726797_ChIP-Seq_SW620_Human	2.04475576
19	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.02480570
20	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.01827084
21	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.01773454
22	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.97539702
23	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.96958995
24	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.93880694
25	RACK7_27058665_Chip-Seq_MCF-7_Human	1.91301237
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.88573551
27	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.87070721
28	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.78668073
29	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.70061859
30	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.69885162
31	ATF3_27146783_Chip-Seq_COLON_Human	1.61648194
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59292935
33	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.51279776
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.47198730
35	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.47163777
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45390317
37	LXR_22292898_ChIP-Seq_THP-1_Human	1.44887310
38	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.43742962
39	SA1_27219007_Chip-Seq_Bcells_Human	1.43607548
40	BCOR_27268052_Chip-Seq_Bcells_Human	1.43437399
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.43234588
42	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.42587365
43	STAT1_20625510_ChIP-Seq_HELA_Human	1.42487629
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.38802593
45	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38739437
46	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.36977974
47	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.36589799
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.36063145
49	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.34087759
50	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.32891793
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30108193
52	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.29876786
53	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.29774852
54	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.27886073
55	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.26428865
56	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25815827
57	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.24806279
58	BCL6_27268052_Chip-Seq_Bcells_Human	1.22899596
59	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.19418588
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.19337585
61	CTCF_20526341_ChIP-Seq_ESCs_Human	1.18825597
62	SOX2_21211035_ChIP-Seq_LN229_Human	1.17931655
63	KLF5_25053715_ChIP-Seq_YYC3_Human	1.17637541
64	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.17372515
65	CTCF_27219007_Chip-Seq_Bcells_Human	1.16796178
66	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.16151199
67	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.10883663
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.10864443
69	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.08482264
70	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.06787702
71	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.06029198
72	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.05010222
73	AR_21909140_ChIP-Seq_LNCAP_Human	1.04878930
74	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.04750968
75	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.03744109
76	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.03593238
77	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.03270038
78	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.02815166
79	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.02742868
80	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.02742868
81	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02359951
82	PHF8_20622854_ChIP-Seq_HELA_Human	1.01188144
83	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.00155413
84	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99534120
85	P300_27268052_Chip-Seq_Bcells_Human	0.97783271
86	ERA_21632823_ChIP-Seq_H3396_Human	0.97345805
87	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.96345989
88	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.93986845
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91653590
90	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.91617155
91	AR_20517297_ChIP-Seq_VCAP_Human	0.90222112
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89168248
93	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.89130828
94	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.89019307
95	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88250955
96	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.88213711
97	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.88069870
98	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86988537
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.86850023
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.86490593

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.39202470
2	MP0001666_abnormal_nutrient_absorption	5.03332460
3	MP0004019_abnormal_vitamin_homeostasis	4.39538700
4	MP0002163_abnormal_gland_morphology	3.59801793
5	MP0002139_abnormal_hepatobiliary_system	3.43666163
6	MP0009379_abnormal_foot_pigmentation	3.19286478
7	MP0004264_abnormal_extraembryonic_tissu	3.08611342
8	MP0010234_abnormal_vibrissa_follicle	3.01737524
9	MP0009840_abnormal_foam_cell	2.95029557
10	MP0005085_abnormal_gallbladder_physiolo	2.91746591
11	MP0003183_abnormal_peptide_metabolism	2.59732221
12	MP0004147_increased_porphyrin_level	2.59463175
13	MP0005365_abnormal_bile_salt	2.57031340
14	MP0010155_abnormal_intestine_physiology	2.56324584
15	MP0003806_abnormal_nucleotide_metabolis	2.28101381
16	MP0003718_maternal_effect	2.19615577
17	MP0001664_abnormal_digestion	2.12707515
18	MP0005379_endocrine/exocrine_gland_phen	2.12574095
19	MP0000490_abnormal_crypts_of	2.07568531
20	MP0010352_gastrointestinal_tract_polyps	2.03313040
21	MP0001873_stomach_inflammation	1.97313180
22	MP0008872_abnormal_physiological_respon	1.95758598
23	MP0001764_abnormal_homeostasis	1.94735660
24	MP0005332_abnormal_amino_acid	1.93785650
25	MP0009643_abnormal_urine_homeostasis	1.85937342
26	MP0005451_abnormal_body_composition	1.78571769
27	MP0002138_abnormal_hepatobiliary_system	1.77989865
28	MP0002796_impaired_skin_barrier	1.73254890
29	MP0000013_abnormal_adipose_tissue	1.64467399
30	MP0000462_abnormal_digestive_system	1.59985236
31	MP0000537_abnormal_urethra_morphology	1.56115925
32	MP0001765_abnormal_ion_homeostasis	1.55022388
33	MP0002876_abnormal_thyroid_physiology	1.54455904
34	MP0000477_abnormal_intestine_morphology	1.53307984
35	MP0008875_abnormal_xenobiotic_pharmacok	1.52362410
36	MP0000538_abnormal_urinary_bladder	1.45826273
37	MP0004858_abnormal_nervous_system	1.43455643
38	MP0001756_abnormal_urination	1.41500642
39	MP0003866_abnormal_defecation	1.39146982
40	MP0002277_abnormal_respiratory_mucosa	1.39138288
41	MP0005636_abnormal_mineral_homeostasis	1.38464793
42	MP0003315_abnormal_perineum_morphology	1.38368239
43	MP0005645_abnormal_hypothalamus_physiol	1.36737451
44	MP0000613_abnormal_salivary_gland	1.35624761
45	MP0010329_abnormal_lipoprotein_level	1.35617705
46	MP0002653_abnormal_ependyma_morphology	1.35576471
47	MP0002136_abnormal_kidney_physiology	1.34422280
48	MP0000678_abnormal_parathyroid_gland	1.31283796
49	MP0002822_catalepsy	1.28579742
50	MP0002098_abnormal_vibrissa_morphology	1.25587361
51	MP0008260_abnormal_autophagy	1.24100638
52	MP0005501_abnormal_skin_physiology	1.23698736
53	MP0005166_decreased_susceptibility_to	1.23240300
54	MP0001663_abnormal_digestive_system	1.20725876
55	MP0003879_abnormal_hair_cell	1.12457772
56	MP0003693_abnormal_embryo_hatching	1.10179124
57	MP0008004_abnormal_stomach_pH	1.09158461
58	MP0005409_darkened_coat_color	1.05540612
59	MP0003191_abnormal_cellular_cholesterol	1.05321504
60	MP0002118_abnormal_lipid_homeostasis	1.04597876
61	MP0004782_abnormal_surfactant_physiolog	1.04172360
62	MP0005381_digestive/alimentary_phenotyp	1.00625819
63	MP0000566_synostosis	0.96751632
64	MP0001727_abnormal_embryo_implantation	0.91961177
65	MP0002938_white_spotting	0.90797907
66	MP0001485_abnormal_pinna_reflex	0.88928015
67	MP0000427_abnormal_hair_cycle	0.85862632
68	MP0000516_abnormal_urinary_system	0.83177384
69	MP0005367_renal/urinary_system_phenotyp	0.83177384
70	MP0000609_abnormal_liver_physiology	0.79151934
71	MP0001845_abnormal_inflammatory_respons	0.78166769
72	MP0005395_other_phenotype	0.76477969
73	MP0005058_abnormal_lysosome_morphology	0.75654359
74	MP0005319_abnormal_enzyme/_coenzyme	0.74871745
75	MP0009333_abnormal_splenocyte_physiolog	0.74421090
76	MP0009764_decreased_sensitivity_to	0.73795789
77	MP0003638_abnormal_response/metabolism_	0.71062524
78	MP0001216_abnormal_epidermal_layer	0.68721037
79	MP0005670_abnormal_white_adipose	0.68576466
80	MP0005584_abnormal_enzyme/coenzyme_acti	0.67272693
81	MP0005377_hearing/vestibular/ear_phenot	0.66729880
82	MP0003878_abnormal_ear_physiology	0.66729880
83	MP0000470_abnormal_stomach_morphology	0.65991897
84	MP0003868_abnormal_feces_composition	0.65731190
85	MP0002254_reproductive_system_inflammat	0.65318149
86	MP0003252_abnormal_bile_duct	0.64623615
87	MP0001501_abnormal_sleep_pattern	0.64455085
88	MP0003186_abnormal_redox_activity	0.63496777
89	MP0005448_abnormal_energy_balance	0.63416838
90	MP0000647_abnormal_sebaceous_gland	0.62687337
91	MP0003953_abnormal_hormone_level	0.59747838
92	MP0005083_abnormal_biliary_tract	0.58119324
93	MP0009642_abnormal_blood_homeostasis	0.55347522
94	MP0008469_abnormal_protein_level	0.53774636
95	MP0005165_increased_susceptibility_to	0.52443006
96	MP0010386_abnormal_urinary_bladder	0.51671567
97	MP0010678_abnormal_skin_adnexa	0.51014290
98	MP0004947_skin_inflammation	0.50245325
99	MP0008775_abnormal_heart_ventricle	0.49425624
100	MP0002078_abnormal_glucose_homeostasis	0.48812088

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	7.97899160
2	Hydroxyprolinuria (HP:0003080)	5.90004911
3	Abnormality of proline metabolism (HP:0010907)	5.90004911
4	Proximal tubulopathy (HP:0000114)	5.88492419
5	Malnutrition (HP:0004395)	5.39635581
6	Nausea (HP:0002018)	4.21738191
7	Abnormality of urine glucose concentration (HP:0011016)	4.05045528
8	Glycosuria (HP:0003076)	4.05045528
9	Systemic lupus erythematosus (HP:0002725)	3.65175209
10	Fat malabsorption (HP:0002630)	3.56001253
11	Congenital sensorineural hearing impairment (HP:0008527)	3.52679188
12	Ileus (HP:0002595)	3.42834264
13	Steatorrhea (HP:0002570)	3.38914052
14	Confusion (HP:0001289)	3.38475774
15	Hyperammonemia (HP:0001987)	3.23484662
16	Focal segmental glomerulosclerosis (HP:0000097)	3.18699783
17	Tongue fasciculations (HP:0001308)	3.01619791
18	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.00809435
19	Hyperphosphaturia (HP:0003109)	2.98463119
20	Abnormality of magnesium homeostasis (HP:0004921)	2.91375179
21	Hypoglycemic coma (HP:0001325)	2.88100125
22	Abnormality of vitamin B metabolism (HP:0004340)	2.84467392
23	Abnormal urine phosphate concentration (HP:0012599)	2.82644996
24	Abnormality of serine family amino acid metabolism (HP:0010894)	2.79525620
25	Abnormality of glycine metabolism (HP:0010895)	2.79525620
26	Thin bony cortex (HP:0002753)	2.73013939
27	Hyperphosphatemia (HP:0002905)	2.69701570
28	Dicarboxylic aciduria (HP:0003215)	2.65557199
29	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.65557199
30	Lethargy (HP:0001254)	2.65143114
31	Hyperglycinuria (HP:0003108)	2.65051122
32	Hypobetalipoproteinemia (HP:0003563)	2.62446930
33	Glomerulosclerosis (HP:0000096)	2.62382921
34	Chronic diarrhea (HP:0002028)	2.61300268
35	Muscle fibrillation (HP:0010546)	2.59437075
36	Pili torti (HP:0003777)	2.56348226
37	Abnormal hair laboratory examination (HP:0003328)	2.54951746
38	Abnormal gallbladder physiology (HP:0012438)	2.53272981
39	Cholecystitis (HP:0001082)	2.53272981
40	Metabolic acidosis (HP:0001942)	2.50263122
41	Villous atrophy (HP:0011473)	2.49839741
42	Abnormality of small intestinal villus morphology (HP:0011472)	2.49839741
43	Decreased circulating renin level (HP:0003351)	2.49191705
44	Increased purine levels (HP:0004368)	2.48090240
45	Hyperuricemia (HP:0002149)	2.48090240
46	Abnormal albumin level (HP:0012116)	2.45329149
47	Hypoalbuminemia (HP:0003073)	2.45329149
48	Stenosis of the external auditory canal (HP:0000402)	2.41416747
49	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.41000752
50	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.39710597
51	Hyperinsulinemic hypoglycemia (HP:0000825)	2.37149259
52	Abnormality of vitamin metabolism (HP:0100508)	2.36820791
53	Hepatic necrosis (HP:0002605)	2.35716323
54	Hypophosphatemia (HP:0002148)	2.34609837
55	Nephrolithiasis (HP:0000787)	2.34211707
56	Alkalosis (HP:0001948)	2.32090584
57	Vacuolated lymphocytes (HP:0001922)	2.29444257
58	Renal tubular acidosis (HP:0001947)	2.26899659
59	Bulbar palsy (HP:0001283)	2.25714636
60	Abdominal distention (HP:0003270)	2.25683440
61	Widely patent fontanelles and sutures (HP:0004492)	2.23121118
62	Ketosis (HP:0001946)	2.22372130
63	Delayed epiphyseal ossification (HP:0002663)	2.20644136
64	Xanthomatosis (HP:0000991)	2.20460328
65	Pancreatitis (HP:0001733)	2.18095603
66	Symptomatic seizures (HP:0011145)	2.17328751
67	Abnormality of purine metabolism (HP:0004352)	2.17123566
68	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.11478104
69	Reticulocytopenia (HP:0001896)	2.10075196
70	Vascular calcification (HP:0004934)	2.07836146
71	Rectal prolapse (HP:0002035)	2.06927255
72	Abnormality of nucleobase metabolism (HP:0010932)	2.06009444
73	Diaphragmatic weakness (HP:0009113)	2.04770586
74	Cerebral palsy (HP:0100021)	1.98381198
75	Hepatocellular necrosis (HP:0001404)	1.98362881
76	Right ventricular cardiomyopathy (HP:0011663)	1.97999435
77	Vomiting (HP:0002013)	1.97722882
78	Brittle hair (HP:0002299)	1.96015761
79	Abnormal trabecular bone morphology (HP:0100671)	1.94722885
80	Polyphagia (HP:0002591)	1.93833406
81	Potter facies (HP:0002009)	1.90548299
82	Facial shape deformation (HP:0011334)	1.90548299
83	Posterior subcapsular cataract (HP:0007787)	1.89938697
84	Ketoacidosis (HP:0001993)	1.89744576
85	Late onset (HP:0003584)	1.88668247
86	Amelogenesis imperfecta (HP:0000705)	1.87717582
87	Hyperparathyroidism (HP:0000843)	1.87118108
88	Renal tubular dysfunction (HP:0000124)	1.86501848
89	Enlarged epiphyses (HP:0010580)	1.86346238
90	Stridor (HP:0010307)	1.85204174
91	Paraparesis (HP:0002385)	1.85017543
92	Pigmentary retinal degeneration (HP:0001146)	1.83976447
93	Abnormality of pyrimidine metabolism (HP:0004353)	1.81760450
94	Tetraparesis (HP:0002273)	1.81719964
95	Hypoglycemic seizures (HP:0002173)	1.81162045
96	Metabolic alkalosis (HP:0200114)	1.80474466
97	Megaloblastic anemia (HP:0001889)	1.79877573
98	Abnormality of renin-angiotensin system (HP:0000847)	1.79686309
99	Myopathic facies (HP:0002058)	1.79630098
100	Generalized aminoaciduria (HP:0002909)	1.73113987

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	7.60204071
2	MAP3K12	3.68363864
3	TLK1	3.63399523
4	LMTK2	3.40707884
5	ZAK	3.11826297
6	MST4	2.89634221
7	ACVR1B	2.78996412
8	MST1R	2.52184656
9	MAP2K2	2.19971349
10	PRKG2	2.10509810
11	MAP3K11	2.09592599
12	TESK1	1.96647993
13	NEK1	1.95431997
14	ERN1	1.95007144
15	LATS1	1.86423425
16	MYLK	1.77657683
17	INSRR	1.75335372
18	TAOK1	1.75146127
19	GRK1	1.74775506
20	STK39	1.62569023
21	TESK2	1.59162966
22	VRK2	1.43200114
23	GRK6	1.42519605
24	PDK2	1.41623256
25	EPHB2	1.37510111
26	BRSK2	1.36168696
27	TRIM28	1.33480585
28	MET	1.30639140
29	PTK6	1.30147588
30	RPS6KB2	1.30034284
31	TBK1	1.28478654
32	DAPK3	1.19280053
33	PRKCI	1.15974393
34	LIMK1	1.15800624
35	NUAK1	1.13994407
36	WNK4	1.09637879
37	EIF2AK1	1.05603866
38	SMG1	1.01722435
39	ABL2	1.00857795
40	CDK19	0.96162378
41	OXSR1	0.94722008
42	VRK1	0.93767636
43	RIPK1	0.93050474
44	MAPKAPK3	0.91243697
45	PIM2	0.83974430
46	MAP3K1	0.79571231
47	MAP3K8	0.75683241
48	PAK4	0.75176128
49	CASK	0.71353839
50	IKBKB	0.69805519
51	DAPK1	0.69260192
52	ADRBK2	0.68494454
53	PBK	0.67825176
54	MAP2K1	0.67456733
55	LRRK2	0.63954300
56	BMX	0.62657849
57	STK38L	0.60958979
58	MAP3K3	0.60564760
59	TNIK	0.59949810
60	MAP4K2	0.57260897
61	MAP4K1	0.56955960
62	PTK2	0.54423424
63	BRSK1	0.54227619
64	ROCK1	0.53530303
65	EPHA4	0.52921637
66	BCR	0.49818823
67	CAMK2G	0.49797172
68	BCKDK	0.47328949
69	AURKB	0.47301507
70	PKN2	0.46668918
71	CAMK2D	0.45633884
72	BRAF	0.44588904
73	TAOK2	0.44122627
74	PRKCA	0.43694155
75	BUB1	0.43448225
76	PRKCZ	0.42732311
77	ARAF	0.39223482
78	FGFR4	0.38535027
79	ILK	0.37138216
80	AURKA	0.36235985
81	MAP3K2	0.36106159
82	EIF2AK3	0.35740975
83	IKBKE	0.34659475
84	ERBB2	0.33619372
85	PRKCQ	0.33581174
86	KDR	0.33573790
87	RPS6KA6	0.33126242
88	RPS6KL1	0.32683202
89	RPS6KC1	0.32683202
90	PIM1	0.29270628
91	NLK	0.28774854
92	PIK3CA	0.27995238
93	MATK	0.27902627
94	PRKCD	0.27318668
95	MAPKAPK2	0.27034245
96	NME2	0.26619766
97	AKT2	0.25953694
98	CAMK2B	0.23729392
99	CHUK	0.23656365
100	DAPK2	0.22727801

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.70249153
2	Fat digestion and absorption_Homo sapiens_hsa04975	4.44690523
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.93196450
4	Sulfur metabolism_Homo sapiens_hsa00920	3.30052999
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.13814262
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.30540596
7	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.29054118
8	Glutathione metabolism_Homo sapiens_hsa00480	2.18368530
9	Mineral absorption_Homo sapiens_hsa04978	2.16726257
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.12754622
11	Sulfur relay system_Homo sapiens_hsa04122	2.06167152
12	Protein digestion and absorption_Homo sapiens_hsa04974	2.04495757
13	Arginine biosynthesis_Homo sapiens_hsa00220	1.99382470
14	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.99173135
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98305823
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.91738382
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.89484524
18	Histidine metabolism_Homo sapiens_hsa00340	1.87645852
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77266353
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.67491058
21	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.61337814
22	Pancreatic secretion_Homo sapiens_hsa04972	1.58366996
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.57357650
24	Retinol metabolism_Homo sapiens_hsa00830	1.56774916
25	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.55327167
26	Caffeine metabolism_Homo sapiens_hsa00232	1.50767938
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.50164851
28	Pentose phosphate pathway_Homo sapiens_hsa00030	1.49709707
29	Arginine and proline metabolism_Homo sapiens_hsa00330	1.43974163
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.43220697
31	Asthma_Homo sapiens_hsa05310	1.38263414
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.37290572
33	Galactose metabolism_Homo sapiens_hsa00052	1.36257682
34	Fatty acid degradation_Homo sapiens_hsa00071	1.32435828
35	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.27189498
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.21785525
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.20748107
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.19582217
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.18836434
40	Bile secretion_Homo sapiens_hsa04976	1.18640170
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.16577802
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10753423
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.08306224
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06974863
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.05761433
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.97201396
47	Carbon metabolism_Homo sapiens_hsa01200	0.89215277
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.86818340
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84756011
50	Proteasome_Homo sapiens_hsa03050	0.83127218
51	PPAR signaling pathway_Homo sapiens_hsa03320	0.82113377
52	Folate biosynthesis_Homo sapiens_hsa00790	0.78740103
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.74627728
54	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72969449
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69336971
56	Ribosome_Homo sapiens_hsa03010	0.69270645
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67926662
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.64172247
59	Tight junction_Homo sapiens_hsa04530	0.62815698
60	Graft-versus-host disease_Homo sapiens_hsa05332	0.62363496
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60993968
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.57850743
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57154617
64	Peroxisome_Homo sapiens_hsa04146	0.56459600
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56450168
66	Metabolic pathways_Homo sapiens_hsa01100	0.55652616
67	Fatty acid elongation_Homo sapiens_hsa00062	0.52132815
68	Allograft rejection_Homo sapiens_hsa05330	0.43650437
69	Antigen processing and presentation_Homo sapiens_hsa04612	0.42230541
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40098541
71	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39645611
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.39636902
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39138531
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37033045
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36172955
76	Parkinsons disease_Homo sapiens_hsa05012	0.34191072
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33726154
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.32516615
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32483308
80	Butanoate metabolism_Homo sapiens_hsa00650	0.31713814
81	Hepatitis C_Homo sapiens_hsa05160	0.31478188
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29195725
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28768200
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27938144
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27354001
86	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.27012766
87	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.25769038
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.25301125
89	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.23735835
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.21769051
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.20359744
92	Insulin secretion_Homo sapiens_hsa04911	0.19839206
93	Purine metabolism_Homo sapiens_hsa00230	0.16716910
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.15861884
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.15596551
96	Base excision repair_Homo sapiens_hsa03410	0.14499991
97	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.14258752
98	Propanoate metabolism_Homo sapiens_hsa00640	0.11996326
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.10936607
100	Huntingtons disease_Homo sapiens_hsa05016	0.09782457

KRT8P49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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