KRT8P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1artery smooth muscle contraction (GO:0014824)6.86956554
2tonic smooth muscle contraction (GO:0014820)5.98110855
3positive regulation of actin filament depolymerization (GO:0030836)5.50374948
4energy homeostasis (GO:0097009)5.38142899
5mitotic nuclear envelope reassembly (GO:0007084)5.32078466
6nuclear envelope reassembly (GO:0031468)5.32078466
7protein maturation by protein folding (GO:0022417)5.29589320
8proteasome assembly (GO:0043248)4.58776837
9inositol phosphate-mediated signaling (GO:0048016)4.26059222
10prostaglandin biosynthetic process (GO:0001516)4.09139932
11prostanoid biosynthetic process (GO:0046457)4.09139932
12type B pancreatic cell proliferation (GO:0044342)4.07090806
13positive regulation of glycoprotein metabolic process (GO:1903020)4.04233330
14GDP-mannose metabolic process (GO:0019673)4.02598105
15nucleotide-sugar biosynthetic process (GO:0009226)4.02087124
16establishment of integrated proviral latency (GO:0075713)3.92919811
17COPI coating of Golgi vesicle (GO:0048205)3.88731030
18Golgi transport vesicle coating (GO:0048200)3.88731030
19protein retention in ER lumen (GO:0006621)3.86606739
20daunorubicin metabolic process (GO:0044597)3.86217684
21polyketide metabolic process (GO:0030638)3.86217684
22doxorubicin metabolic process (GO:0044598)3.86217684
23establishment of viral latency (GO:0019043)3.84592547
24hepatocyte apoptotic process (GO:0097284)3.76310158
25inner mitochondrial membrane organization (GO:0007007)3.68333068
26nucleoside transport (GO:0015858)3.67047118
27autophagic vacuole fusion (GO:0000046)3.65338488
28ganglion development (GO:0061548)3.63100517
29endothelial tube morphogenesis (GO:0061154)3.60781804
30morphogenesis of an endothelium (GO:0003159)3.60781804
31vascular smooth muscle contraction (GO:0014829)3.59580319
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55760069
33negative regulation of mitochondrion organization (GO:0010823)3.54271806
34positive regulation of glycoprotein biosynthetic process (GO:0010560)3.48471107
35nucleoside transmembrane transport (GO:1901642)3.46947446
36interferon-gamma secretion (GO:0072643)3.45878686
37regulation of metalloenzyme activity (GO:0048552)3.43531017
38regulation of mitochondrial translation (GO:0070129)3.43074501
39prostaglandin metabolic process (GO:0006693)3.40574410
40prostanoid metabolic process (GO:0006692)3.40574410
41aminoglycoside antibiotic metabolic process (GO:0030647)3.38456759
42chaperone-mediated protein transport (GO:0072321)3.38311739
43organelle membrane fusion (GO:0090174)3.36353813
44positive regulation of heart rate (GO:0010460)3.32047357
45regulation of cell proliferation involved in kidney development (GO:1901722)3.29871755
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26121737
47desmosome organization (GO:0002934)3.24387934
48mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.23915459
49ribosome assembly (GO:0042255)3.19761594
50regulation of cellular amino acid metabolic process (GO:0006521)3.19510491
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14502458
52positive regulation of growth hormone secretion (GO:0060124)3.12537241
53regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.12315275
54phasic smooth muscle contraction (GO:0014821)3.09079937
55purine ribonucleotide transport (GO:0015868)3.05576135
56positive regulation of protein depolymerization (GO:1901881)2.98257180
57pyrimidine-containing compound transmembrane transport (GO:0072531)2.98000473
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96324359
59positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.94109641
60phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92596682
61mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92223894
62mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92223894
63muscle cell migration (GO:0014812)2.91399069
64negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.90801164
65protein localization to endosome (GO:0036010)2.88271475
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86806969
67glycoside metabolic process (GO:0016137)2.85197084
68bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82563037
69cobalamin metabolic process (GO:0009235)2.77388926
70protein deneddylation (GO:0000338)2.76608167
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76177963
72negative regulation of ligase activity (GO:0051352)2.76177963
73cullin deneddylation (GO:0010388)2.75425735
74lung secretory cell differentiation (GO:0061140)2.74395379
75negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.74208449
76dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.73237528
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70938184
78activation of Rac GTPase activity (GO:0032863)2.69614440
79negative regulation of glycogen metabolic process (GO:0070874)2.69355727
80actin filament depolymerization (GO:0030042)2.69058622
81mesonephros development (GO:0001823)2.68729219
82xenobiotic catabolic process (GO:0042178)2.68438615
83regulation of cellular respiration (GO:0043457)2.67451017
84positive regulation of heart contraction (GO:0045823)2.66341376
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64612952
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63292584
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63292584
88pattern specification involved in kidney development (GO:0061004)2.63013271
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61670187
90protein hydroxylation (GO:0018126)2.61488799
91extracellular fibril organization (GO:0043206)2.61009640
92nucleoside salvage (GO:0043174)2.60631540
93positive regulation of ligase activity (GO:0051351)2.59793363
94adenine nucleotide transport (GO:0051503)2.59022812
95glutathione derivative biosynthetic process (GO:1901687)2.58941338
96glutathione derivative metabolic process (GO:1901685)2.58941338
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58679817
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58679817
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58679817
100endocardial cushion development (GO:0003197)2.56261992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.52580665
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.19872317
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.79544307
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53246804
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21910071
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16444811
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11557154
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78652255
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63677687
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57751035
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55122073
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44468701
13ZNF263_19887448_ChIP-Seq_K562_Human2.41494983
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.39874978
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31181013
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29133449
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.25566309
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.24447615
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19751825
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.15135193
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09410874
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.06970819
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03897809
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99141228
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91692691
26ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.83933341
27GABP_19822575_ChIP-Seq_HepG2_Human1.79576131
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77100093
29DCP1A_22483619_ChIP-Seq_HELA_Human1.75430001
30RACK7_27058665_Chip-Seq_MCF-7_Human1.70757908
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.70682218
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68589043
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62885511
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.61616550
35ATF3_27146783_Chip-Seq_COLON_Human1.58440431
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56228519
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55538640
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54869794
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53367527
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.53000271
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.51964186
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.50754029
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50120918
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.47536200
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47213485
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44151188
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44022956
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44022956
49HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43261428
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42879562
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42694920
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41983261
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40559739
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40394386
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.39329711
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38892668
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38051372
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37855035
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37226404
60KDM5A_27292631_Chip-Seq_BREAST_Human1.35443613
61XRN2_22483619_ChIP-Seq_HELA_Human1.35243869
62GATA6_25053715_ChIP-Seq_YYC3_Human1.26652344
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26183138
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18552582
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18349044
66ELF5_23300383_ChIP-Seq_T47D_Human1.16973057
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.16944140
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16794212
69TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.16617636
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16012396
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15997842
72EOMES_21245162_ChIP-Seq_HESCs_Human1.13921291
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12799963
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12702900
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11252631
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11015306
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10089996
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09794371
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09784174
80P68_20966046_ChIP-Seq_HELA_Human1.09524776
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.09417116
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08095275
83AR_21909140_ChIP-Seq_LNCAP_Human1.07338704
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06995393
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.05545285
86TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04800347
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04800341
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04087419
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03577271
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00115457
91FOXP3_21729870_ChIP-Seq_TREG_Human1.00021043
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99804459
93GATA4_25053715_ChIP-Seq_YYC3_Human0.99649584
94VDR_23849224_ChIP-Seq_CD4+_Human0.98505901
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98431818
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98352419
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97305102
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96284983
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96157379
100SOX2_20726797_ChIP-Seq_SW620_Human0.95607947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.48412151
2MP0010234_abnormal_vibrissa_follicle4.03690961
3MP0003806_abnormal_nucleotide_metabolis3.76253876
4MP0002822_catalepsy3.30733185
5MP0000647_abnormal_sebaceous_gland2.88481944
6MP0009780_abnormal_chondrocyte_physiolo2.81006837
7MP0005257_abnormal_intraocular_pressure2.63776899
8MP0000516_abnormal_urinary_system2.63031124
9MP0005367_renal/urinary_system_phenotyp2.63031124
10MP0003718_maternal_effect2.54631472
11MP0004264_abnormal_extraembryonic_tissu2.43158149
12MP0008789_abnormal_olfactory_epithelium2.38982763
13MP0008775_abnormal_heart_ventricle2.33882534
14MP0010030_abnormal_orbit_morphology2.31478300
15MP0005360_urolithiasis2.23042598
16MP0002796_impaired_skin_barrier2.18954355
17MP0001666_abnormal_nutrient_absorption2.16321141
18MP0003315_abnormal_perineum_morphology2.03426584
19MP0005083_abnormal_biliary_tract1.91389507
20MP0003693_abnormal_embryo_hatching1.84886750
21MP0000427_abnormal_hair_cycle1.78091151
22MP0003786_premature_aging1.77839026
23MP0004957_abnormal_blastocyst_morpholog1.76308652
24MP0000537_abnormal_urethra_morphology1.70439727
25MP0010352_gastrointestinal_tract_polyps1.66607270
26MP0005501_abnormal_skin_physiology1.63513150
27MP0005670_abnormal_white_adipose1.58624241
28MP0010678_abnormal_skin_adnexa1.56569017
29MP0000358_abnormal_cell_content/1.49748895
30MP0008932_abnormal_embryonic_tissue1.43919517
31MP0001905_abnormal_dopamine_level1.40745064
32MP0002751_abnormal_autonomic_nervous1.40661852
33MP0008875_abnormal_xenobiotic_pharmacok1.39572544
34MP0002060_abnormal_skin_morphology1.37509390
35MP0005165_increased_susceptibility_to1.34251043
36MP0005365_abnormal_bile_salt1.33555201
37MP0003566_abnormal_cell_adhesion1.32539841
38MP0001664_abnormal_digestion1.32238946
39MP0002332_abnormal_exercise_endurance1.31545382
40MP0005394_taste/olfaction_phenotype1.31249531
41MP0005499_abnormal_olfactory_system1.31249531
42MP0000613_abnormal_salivary_gland1.29111343
43MP0002163_abnormal_gland_morphology1.26632804
44MP0006035_abnormal_mitochondrial_morpho1.25731956
45MP0000750_abnormal_muscle_regeneration1.23979833
46MP0003191_abnormal_cellular_cholesterol1.23966521
47MP0003950_abnormal_plasma_membrane1.20148196
48MP0002938_white_spotting1.17647856
49MP0010771_integument_phenotype1.16584768
50MP0006054_spinal_hemorrhage1.16264351
51MP0004272_abnormal_basement_membrane1.13174429
52MP0000383_abnormal_hair_follicle1.10589444
53MP0002177_abnormal_outer_ear1.09583631
54MP0001243_abnormal_dermal_layer1.06654706
55MP0001529_abnormal_vocalization1.05996037
56MP0003121_genomic_imprinting1.04059939
57MP0000762_abnormal_tongue_morphology1.03547174
58MP0005084_abnormal_gallbladder_morpholo1.02872697
59MP0005330_cardiomyopathy1.01963768
60MP0009840_abnormal_foam_cell1.00114230
61MP0001216_abnormal_epidermal_layer0.97056826
62MP0006036_abnormal_mitochondrial_physio0.96836564
63MP0001730_embryonic_growth_arrest0.96213686
64MP0003943_abnormal_hepatobiliary_system0.95237868
65MP0000462_abnormal_digestive_system0.94680298
66MP0005395_other_phenotype0.93645096
67MP0006276_abnormal_autonomic_nervous0.92187084
68MP0001756_abnormal_urination0.91871726
69MP0002653_abnormal_ependyma_morphology0.91029324
70MP0005058_abnormal_lysosome_morphology0.90896507
71MP0001340_abnormal_eyelid_morphology0.90803002
72MP0003119_abnormal_digestive_system0.89648115
73MP0003638_abnormal_response/metabolism_0.87767423
74MP0003942_abnormal_urinary_system0.87003925
75MP0008260_abnormal_autophagy0.85728623
76MP0006292_abnormal_olfactory_placode0.84283552
77MP0001346_abnormal_lacrimal_gland0.83121580
78MP0000377_abnormal_hair_follicle0.82672472
79MP0008872_abnormal_physiological_respon0.80626528
80MP0005380_embryogenesis_phenotype0.76747100
81MP0001672_abnormal_embryogenesis/_devel0.76747100
82MP0002080_prenatal_lethality0.76700221
83MP0002098_abnormal_vibrissa_morphology0.76222099
84MP0001293_anophthalmia0.73982758
85MP0002970_abnormal_white_adipose0.73897942
86MP0003787_abnormal_imprinting0.73682013
87MP0003984_embryonic_growth_retardation0.72898953
88MP0001542_abnormal_bone_strength0.72352851
89MP0001697_abnormal_embryo_size0.72088350
90MP0005187_abnormal_penis_morphology0.70213354
91MP0004147_increased_porphyrin_level0.68299592
92MP0002088_abnormal_embryonic_growth/wei0.67629091
93MP0005452_abnormal_adipose_tissue0.67088234
94MP0003111_abnormal_nucleus_morphology0.65246921
95MP0005646_abnormal_pituitary_gland0.64119213
96MP0009053_abnormal_anal_canal0.62790805
97MP0002095_abnormal_skin_pigmentation0.62728374
98MP0002909_abnormal_adrenal_gland0.62336309
99MP0000747_muscle_weakness0.61249772
100MP0004185_abnormal_adipocyte_glucose0.60755633

Predicted human phenotypes

RankGene SetZ-score
1Adrenal hypoplasia (HP:0000835)4.65403712
2Vascular calcification (HP:0004934)3.94007233
3Reduced subcutaneous adipose tissue (HP:0003758)3.71578958
4Upper limb muscle weakness (HP:0003484)3.62806404
5Microretrognathia (HP:0000308)3.51521072
6Cardiovascular calcification (HP:0011915)3.31120205
7Delayed CNS myelination (HP:0002188)3.16719784
8Microglossia (HP:0000171)3.15536513
9Sparse eyelashes (HP:0000653)3.12084383
10Glucose intolerance (HP:0000833)3.01797615
11Abnormal mitochondria in muscle tissue (HP:0008316)2.98819139
12Acute necrotizing encephalopathy (HP:0006965)2.86744397
13Distal lower limb muscle weakness (HP:0009053)2.85439561
14Type I transferrin isoform profile (HP:0003642)2.81848322
15Right ventricular cardiomyopathy (HP:0011663)2.80369833
16Rough bone trabeculation (HP:0100670)2.72434392
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68232298
18Abnormal protein N-linked glycosylation (HP:0012347)2.68232298
19Abnormal protein glycosylation (HP:0012346)2.68232298
20Abnormal glycosylation (HP:0012345)2.68232298
21Hepatic necrosis (HP:0002605)2.67359148
22Acute encephalopathy (HP:0006846)2.67100578
23Entropion (HP:0000621)2.66752814
24Hand muscle atrophy (HP:0009130)2.64035529
25Prolonged neonatal jaundice (HP:0006579)2.59316368
26Abnormality of the distal phalanges of the toes (HP:0010182)2.58598010
27Abnormality of glycolysis (HP:0004366)2.57000327
28Hepatocellular necrosis (HP:0001404)2.50596709
29Increased serum pyruvate (HP:0003542)2.47403064
30Micronodular cirrhosis (HP:0001413)2.46808630
31Mitochondrial inheritance (HP:0001427)2.45479919
32Progressive macrocephaly (HP:0004481)2.43467937
33Tongue fasciculations (HP:0001308)2.43429394
34Alopecia of scalp (HP:0002293)2.41261100
35Distal upper limb amyotrophy (HP:0007149)2.37388919
36Upper limb amyotrophy (HP:0009129)2.37388919
37Cholecystitis (HP:0001082)2.34056846
38Abnormal gallbladder physiology (HP:0012438)2.34056846
39Short nail (HP:0001799)2.29451649
40Unilateral renal agenesis (HP:0000122)2.28102363
41Secondary amenorrhea (HP:0000869)2.24837691
42Spastic paraparesis (HP:0002313)2.23091542
43Distal lower limb amyotrophy (HP:0008944)2.22483424
44Severe muscular hypotonia (HP:0006829)2.17784990
45Tetraparesis (HP:0002273)2.15635890
46Hyperphosphatemia (HP:0002905)2.14035963
47Increased CSF lactate (HP:0002490)2.13820511
48Congenital ichthyosiform erythroderma (HP:0007431)2.10992599
49Reduced antithrombin III activity (HP:0001976)2.10419099
50Hypoplasia of the pons (HP:0012110)2.10392738
51Amyloidosis (HP:0011034)2.10082834
52Muscle fibrillation (HP:0010546)2.07761055
53Bifid uvula (HP:0000193)2.07011547
54Progressive hearing impairment (HP:0001730)2.04868868
55Limb-girdle muscle atrophy (HP:0003797)2.04783874
56Palpitations (HP:0001962)2.02970737
57Pili torti (HP:0003777)2.01192662
58Progressive muscle weakness (HP:0003323)1.99245756
59Hypokinesia (HP:0002375)1.97374558
60Abnormality of the pons (HP:0007361)1.97144246
61Abnormal trabecular bone morphology (HP:0100671)1.95882476
62Opisthotonus (HP:0002179)1.95877564
63Steatorrhea (HP:0002570)1.93703258
64Anteriorly placed anus (HP:0001545)1.91298733
65Heterochromia iridis (HP:0001100)1.91010958
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90760136
67Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90760136
68Abnormality of alanine metabolism (HP:0010916)1.90549321
69Hyperalaninemia (HP:0003348)1.90549321
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90549321
71Insulin resistance (HP:0000855)1.90525281
72Nausea (HP:0002018)1.89152897
73Generalized aminoaciduria (HP:0002909)1.88598689
74Fasciculations (HP:0002380)1.87301857
75Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87121405
76Acanthosis nigricans (HP:0000956)1.87096716
77Paraparesis (HP:0002385)1.86845800
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86728376
79Short 1st metacarpal (HP:0010034)1.86728376
80Cerebral hypomyelination (HP:0006808)1.85118514
81Increased serum lactate (HP:0002151)1.84607117
82J-shaped sella turcica (HP:0002680)1.83190568
83Bradycardia (HP:0001662)1.82918148
84Abnormal glucose tolerance (HP:0001952)1.81979886
85Median cleft lip (HP:0000161)1.81828722
86Cerebellar dysplasia (HP:0007033)1.80906077
87Exercise intolerance (HP:0003546)1.80818164
88Shoulder girdle muscle weakness (HP:0003547)1.80001518
89Abnormality of the sella turcica (HP:0002679)1.79360185
90Proximal placement of thumb (HP:0009623)1.76734915
91Septate vagina (HP:0001153)1.76671335
92Premature rupture of membranes (HP:0001788)1.76461773
93Difficulty climbing stairs (HP:0003551)1.75447930
94Hypoplasia of the fovea (HP:0007750)1.75088271
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.75088271
96Abnormality of the umbilical cord (HP:0010881)1.74599691
97Respiratory failure (HP:0002878)1.74264464
98Hypoplasia of the uterus (HP:0000013)1.73026962
99Hypergonadotropic hypogonadism (HP:0000815)1.71052064
100Vertebral compression fractures (HP:0002953)1.70383119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.56119319
2TESK14.74749831
3NME24.59630042
4TESK23.71175349
5LMTK23.57094130
6LIMK13.54892989
7VRK23.33484973
8MST43.17345673
9MST1R2.73203073
10MAP3K122.11986433
11PBK1.96665185
12PAK41.73394777
13PHKG11.67449197
14PHKG21.67449197
15MAP2K71.56601719
16NEK11.54299968
17ARAF1.52091867
18DAPK11.51957713
19MAPKAPK31.51369147
20SCYL21.51258263
21TLK11.51157058
22PTK2B1.46475587
23BUB11.45647093
24MET1.39766698
25EIF2AK11.34636128
26CSNK1G31.33019425
27AURKA1.32033046
28PIM21.30540829
29MOS1.28547415
30BCKDK1.27562115
31ILK1.21772383
32RPS6KB21.13638408
33CSNK1G21.12890980
34BRSK11.08139579
35VRK11.07317796
36ABL21.05839344
37CSNK1A1L1.03546535
38FER1.00610344
39PDK20.99375250
40PTK20.98256828
41NEK90.98079803
42MYLK0.96878048
43CSNK1G10.93677843
44PRKCI0.88432822
45STK100.88129568
46TAOK20.83686412
47KDR0.82936951
48ERBB40.79395826
49CDK190.77536511
50ERN10.74129562
51NME10.73388398
52DAPK20.66422877
53AKT20.64893748
54CDK120.63233959
55DAPK30.62655739
56STK160.60677875
57CAMK2D0.57919189
58PAK10.56640954
59PTK60.55532460
60MAP3K10.54294868
61CAMK2G0.53632829
62ERBB20.50622581
63LATS20.50553691
64MAP3K80.49824691
65ROCK10.49648977
66ZAK0.48017031
67OXSR10.46406193
68SRPK10.42506052
69LRRK20.42197869
70AURKB0.41017213
71PRKG20.40488421
72MUSK0.40276225
73BMX0.37517912
74MAP2K20.37074334
75TRIB30.37012298
76IRAK30.37006796
77CDK70.35561493
78EPHB10.35450969
79PLK10.34271708
80MAP3K30.33325327
81EPHB20.33228393
82PRKCE0.32702182
83EIF2AK30.31768348
84CCNB10.31247831
85BRD40.29829343
86FGFR20.29035197
87ADRBK10.27804549
88SIK30.27775625
89ROCK20.27604293
90TBK10.27441288
91GRK10.27236278
92EPHA40.26650189
93PRKD20.26181556
94SIK10.25838847
95TRIM280.25815420
96INSRR0.25788030
97CSNK1A10.25435551
98PRKD10.25233794
99CDK140.24958385
100PKN20.24805470

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.71738644
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63048962
3Fatty acid elongation_Homo sapiens_hsa000622.34286052
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.31022845
5Folate biosynthesis_Homo sapiens_hsa007902.27163838
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26371624
7Glutathione metabolism_Homo sapiens_hsa004802.23199047
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.18843940
9Fructose and mannose metabolism_Homo sapiens_hsa000512.15250314
10Vibrio cholerae infection_Homo sapiens_hsa051102.11588431
11Oxidative phosphorylation_Homo sapiens_hsa001902.10221205
12Sulfur relay system_Homo sapiens_hsa041221.95537565
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.83558110
14Parkinsons disease_Homo sapiens_hsa050121.81816303
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80568499
16Pentose phosphate pathway_Homo sapiens_hsa000301.66518335
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.64102350
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.60421072
19Pyrimidine metabolism_Homo sapiens_hsa002401.59985584
20DNA replication_Homo sapiens_hsa030301.53217410
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.53065208
22Galactose metabolism_Homo sapiens_hsa000521.52834191
23Huntingtons disease_Homo sapiens_hsa050161.52732748
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52698221
25Pancreatic secretion_Homo sapiens_hsa049721.48835013
26Biosynthesis of amino acids_Homo sapiens_hsa012301.46386084
27Spliceosome_Homo sapiens_hsa030401.44455693
28Synaptic vesicle cycle_Homo sapiens_hsa047211.44321512
29Steroid biosynthesis_Homo sapiens_hsa001001.42855539
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37966720
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33325543
32RNA polymerase_Homo sapiens_hsa030201.29965636
33Alzheimers disease_Homo sapiens_hsa050101.29211416
34RNA transport_Homo sapiens_hsa030131.25333784
35Pyruvate metabolism_Homo sapiens_hsa006201.23830123
36Nucleotide excision repair_Homo sapiens_hsa034201.22219599
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18550160
38Ribosome_Homo sapiens_hsa030101.18341675
39Base excision repair_Homo sapiens_hsa034101.17758595
40N-Glycan biosynthesis_Homo sapiens_hsa005101.17394087
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16969627
42Collecting duct acid secretion_Homo sapiens_hsa049661.14922325
43Mismatch repair_Homo sapiens_hsa034301.12337838
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11872362
45Carbon metabolism_Homo sapiens_hsa012001.11871292
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10084763
47Tight junction_Homo sapiens_hsa045301.07863207
48Homologous recombination_Homo sapiens_hsa034401.07693679
49Basal transcription factors_Homo sapiens_hsa030221.06286120
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05158066
51Protein digestion and absorption_Homo sapiens_hsa049741.02496825
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99971663
53Fat digestion and absorption_Homo sapiens_hsa049750.97031133
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92422722
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90661314
56Purine metabolism_Homo sapiens_hsa002300.88847359
57Salivary secretion_Homo sapiens_hsa049700.86939512
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83078127
59Starch and sucrose metabolism_Homo sapiens_hsa005000.82610065
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81652383
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72009354
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.71923672
63Metabolic pathways_Homo sapiens_hsa011000.71891170
64Circadian rhythm_Homo sapiens_hsa047100.71469117
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69023660
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67076402
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64676148
68Chemical carcinogenesis_Homo sapiens_hsa052040.64547381
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63382821
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.62419360
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62233150
72Other glycan degradation_Homo sapiens_hsa005110.62194853
73Hippo signaling pathway_Homo sapiens_hsa043900.61733374
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.61077734
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60675497
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60112935
77Sulfur metabolism_Homo sapiens_hsa009200.58585732
78Endocytosis_Homo sapiens_hsa041440.58022545
79Arginine and proline metabolism_Homo sapiens_hsa003300.57479345
80Hedgehog signaling pathway_Homo sapiens_hsa043400.54038484
81Sphingolipid metabolism_Homo sapiens_hsa006000.50600436
82Phenylalanine metabolism_Homo sapiens_hsa003600.49075642
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48238940
84Shigellosis_Homo sapiens_hsa051310.47204742
85Cardiac muscle contraction_Homo sapiens_hsa042600.46839550
86Lysosome_Homo sapiens_hsa041420.46829800
87Non-homologous end-joining_Homo sapiens_hsa034500.45507863
88Lysine degradation_Homo sapiens_hsa003100.44481187
89Thyroid cancer_Homo sapiens_hsa052160.43606318
90p53 signaling pathway_Homo sapiens_hsa041150.41275829
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37683010
92Alcoholism_Homo sapiens_hsa050340.36909746
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36003873
94mRNA surveillance pathway_Homo sapiens_hsa030150.35718035
95Adherens junction_Homo sapiens_hsa045200.35568937
96Arachidonic acid metabolism_Homo sapiens_hsa005900.32420072
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31606968
98Tyrosine metabolism_Homo sapiens_hsa003500.31543528
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29215658
100Ovarian steroidogenesis_Homo sapiens_hsa049130.26829544

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