

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | artery smooth muscle contraction (GO:0014824) | 6.86956554 |
| 2 | tonic smooth muscle contraction (GO:0014820) | 5.98110855 |
| 3 | positive regulation of actin filament depolymerization (GO:0030836) | 5.50374948 |
| 4 | energy homeostasis (GO:0097009) | 5.38142899 |
| 5 | mitotic nuclear envelope reassembly (GO:0007084) | 5.32078466 |
| 6 | nuclear envelope reassembly (GO:0031468) | 5.32078466 |
| 7 | protein maturation by protein folding (GO:0022417) | 5.29589320 |
| 8 | proteasome assembly (GO:0043248) | 4.58776837 |
| 9 | inositol phosphate-mediated signaling (GO:0048016) | 4.26059222 |
| 10 | prostaglandin biosynthetic process (GO:0001516) | 4.09139932 |
| 11 | prostanoid biosynthetic process (GO:0046457) | 4.09139932 |
| 12 | type B pancreatic cell proliferation (GO:0044342) | 4.07090806 |
| 13 | positive regulation of glycoprotein metabolic process (GO:1903020) | 4.04233330 |
| 14 | GDP-mannose metabolic process (GO:0019673) | 4.02598105 |
| 15 | nucleotide-sugar biosynthetic process (GO:0009226) | 4.02087124 |
| 16 | establishment of integrated proviral latency (GO:0075713) | 3.92919811 |
| 17 | COPI coating of Golgi vesicle (GO:0048205) | 3.88731030 |
| 18 | Golgi transport vesicle coating (GO:0048200) | 3.88731030 |
| 19 | protein retention in ER lumen (GO:0006621) | 3.86606739 |
| 20 | daunorubicin metabolic process (GO:0044597) | 3.86217684 |
| 21 | polyketide metabolic process (GO:0030638) | 3.86217684 |
| 22 | doxorubicin metabolic process (GO:0044598) | 3.86217684 |
| 23 | establishment of viral latency (GO:0019043) | 3.84592547 |
| 24 | hepatocyte apoptotic process (GO:0097284) | 3.76310158 |
| 25 | inner mitochondrial membrane organization (GO:0007007) | 3.68333068 |
| 26 | nucleoside transport (GO:0015858) | 3.67047118 |
| 27 | autophagic vacuole fusion (GO:0000046) | 3.65338488 |
| 28 | ganglion development (GO:0061548) | 3.63100517 |
| 29 | endothelial tube morphogenesis (GO:0061154) | 3.60781804 |
| 30 | morphogenesis of an endothelium (GO:0003159) | 3.60781804 |
| 31 | vascular smooth muscle contraction (GO:0014829) | 3.59580319 |
| 32 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.55760069 |
| 33 | negative regulation of mitochondrion organization (GO:0010823) | 3.54271806 |
| 34 | positive regulation of glycoprotein biosynthetic process (GO:0010560) | 3.48471107 |
| 35 | nucleoside transmembrane transport (GO:1901642) | 3.46947446 |
| 36 | interferon-gamma secretion (GO:0072643) | 3.45878686 |
| 37 | regulation of metalloenzyme activity (GO:0048552) | 3.43531017 |
| 38 | regulation of mitochondrial translation (GO:0070129) | 3.43074501 |
| 39 | prostaglandin metabolic process (GO:0006693) | 3.40574410 |
| 40 | prostanoid metabolic process (GO:0006692) | 3.40574410 |
| 41 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.38456759 |
| 42 | chaperone-mediated protein transport (GO:0072321) | 3.38311739 |
| 43 | organelle membrane fusion (GO:0090174) | 3.36353813 |
| 44 | positive regulation of heart rate (GO:0010460) | 3.32047357 |
| 45 | regulation of cell proliferation involved in kidney development (GO:1901722) | 3.29871755 |
| 46 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.26121737 |
| 47 | desmosome organization (GO:0002934) | 3.24387934 |
| 48 | mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337) | 3.23915459 |
| 49 | ribosome assembly (GO:0042255) | 3.19761594 |
| 50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.19510491 |
| 51 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14502458 |
| 52 | positive regulation of growth hormone secretion (GO:0060124) | 3.12537241 |
| 53 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 3.12315275 |
| 54 | phasic smooth muscle contraction (GO:0014821) | 3.09079937 |
| 55 | purine ribonucleotide transport (GO:0015868) | 3.05576135 |
| 56 | positive regulation of protein depolymerization (GO:1901881) | 2.98257180 |
| 57 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 2.98000473 |
| 58 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.96324359 |
| 59 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 2.94109641 |
| 60 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 2.92596682 |
| 61 | mesenchymal cell differentiation involved in renal system development (GO:2001012) | 2.92223894 |
| 62 | mesenchymal cell differentiation involved in kidney development (GO:0072161) | 2.92223894 |
| 63 | muscle cell migration (GO:0014812) | 2.91399069 |
| 64 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.90801164 |
| 65 | protein localization to endosome (GO:0036010) | 2.88271475 |
| 66 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.86806969 |
| 67 | glycoside metabolic process (GO:0016137) | 2.85197084 |
| 68 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 2.82563037 |
| 69 | cobalamin metabolic process (GO:0009235) | 2.77388926 |
| 70 | protein deneddylation (GO:0000338) | 2.76608167 |
| 71 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.76177963 |
| 72 | negative regulation of ligase activity (GO:0051352) | 2.76177963 |
| 73 | cullin deneddylation (GO:0010388) | 2.75425735 |
| 74 | lung secretory cell differentiation (GO:0061140) | 2.74395379 |
| 75 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.74208449 |
| 76 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.73237528 |
| 77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.70938184 |
| 78 | activation of Rac GTPase activity (GO:0032863) | 2.69614440 |
| 79 | negative regulation of glycogen metabolic process (GO:0070874) | 2.69355727 |
| 80 | actin filament depolymerization (GO:0030042) | 2.69058622 |
| 81 | mesonephros development (GO:0001823) | 2.68729219 |
| 82 | xenobiotic catabolic process (GO:0042178) | 2.68438615 |
| 83 | regulation of cellular respiration (GO:0043457) | 2.67451017 |
| 84 | positive regulation of heart contraction (GO:0045823) | 2.66341376 |
| 85 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.64612952 |
| 86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.63292584 |
| 87 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.63292584 |
| 88 | pattern specification involved in kidney development (GO:0061004) | 2.63013271 |
| 89 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.61670187 |
| 90 | protein hydroxylation (GO:0018126) | 2.61488799 |
| 91 | extracellular fibril organization (GO:0043206) | 2.61009640 |
| 92 | nucleoside salvage (GO:0043174) | 2.60631540 |
| 93 | positive regulation of ligase activity (GO:0051351) | 2.59793363 |
| 94 | adenine nucleotide transport (GO:0051503) | 2.59022812 |
| 95 | glutathione derivative biosynthetic process (GO:1901687) | 2.58941338 |
| 96 | glutathione derivative metabolic process (GO:1901685) | 2.58941338 |
| 97 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.58679817 |
| 98 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.58679817 |
| 99 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.58679817 |
| 100 | endocardial cushion development (GO:0003197) | 2.56261992 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 4.52580665 |
| 2 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 4.19872317 |
| 3 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.79544307 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.53246804 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.21910071 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.16444811 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.11557154 |
| 8 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.78652255 |
| 9 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.63677687 |
| 10 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.57751035 |
| 11 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.55122073 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.44468701 |
| 13 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.41494983 |
| 14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.39874978 |
| 15 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.31181013 |
| 16 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.29133449 |
| 17 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 2.25566309 |
| 18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.24447615 |
| 19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.19751825 |
| 20 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.15135193 |
| 21 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.09410874 |
| 22 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.06970819 |
| 23 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.03897809 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.99141228 |
| 25 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.91692691 |
| 26 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.83933341 |
| 27 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.79576131 |
| 28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.77100093 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.75430001 |
| 30 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.70757908 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.70682218 |
| 32 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.68589043 |
| 33 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.62885511 |
| 34 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.61616550 |
| 35 | ATF3_27146783_Chip-Seq_COLON_Human | 1.58440431 |
| 36 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.56228519 |
| 37 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.55538640 |
| 38 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.54869794 |
| 39 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.53367527 |
| 40 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.53000271 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.51964186 |
| 42 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.50754029 |
| 43 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.50120918 |
| 44 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.47536200 |
| 45 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.47213485 |
| 46 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.44151188 |
| 47 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.44022956 |
| 48 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.44022956 |
| 49 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.43261428 |
| 50 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.42879562 |
| 51 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.42694920 |
| 52 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.41983261 |
| 53 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.40559739 |
| 54 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.40394386 |
| 55 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.39329711 |
| 56 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.38892668 |
| 57 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.38051372 |
| 58 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.37855035 |
| 59 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.37226404 |
| 60 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.35443613 |
| 61 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.35243869 |
| 62 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.26652344 |
| 63 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.26183138 |
| 64 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.18552582 |
| 65 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.18349044 |
| 66 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.16973057 |
| 67 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.16944140 |
| 68 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.16794212 |
| 69 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 1.16617636 |
| 70 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.16012396 |
| 71 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.15997842 |
| 72 | EOMES_21245162_ChIP-Seq_HESCs_Human | 1.13921291 |
| 73 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12799963 |
| 74 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.12702900 |
| 75 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.11252631 |
| 76 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.11015306 |
| 77 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.10089996 |
| 78 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.09794371 |
| 79 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.09784174 |
| 80 | P68_20966046_ChIP-Seq_HELA_Human | 1.09524776 |
| 81 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.09417116 |
| 82 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.08095275 |
| 83 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.07338704 |
| 84 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.06995393 |
| 85 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.05545285 |
| 86 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.04800347 |
| 87 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.04800341 |
| 88 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.04087419 |
| 89 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.03577271 |
| 90 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.00115457 |
| 91 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.00021043 |
| 92 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.99804459 |
| 93 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.99649584 |
| 94 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.98505901 |
| 95 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98431818 |
| 96 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.98352419 |
| 97 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97305102 |
| 98 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96284983 |
| 99 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.96157379 |
| 100 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.95607947 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003123_paternal_imprinting | 4.48412151 |
| 2 | MP0010234_abnormal_vibrissa_follicle | 4.03690961 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.76253876 |
| 4 | MP0002822_catalepsy | 3.30733185 |
| 5 | MP0000647_abnormal_sebaceous_gland | 2.88481944 |
| 6 | MP0009780_abnormal_chondrocyte_physiolo | 2.81006837 |
| 7 | MP0005257_abnormal_intraocular_pressure | 2.63776899 |
| 8 | MP0000516_abnormal_urinary_system | 2.63031124 |
| 9 | MP0005367_renal/urinary_system_phenotyp | 2.63031124 |
| 10 | MP0003718_maternal_effect | 2.54631472 |
| 11 | MP0004264_abnormal_extraembryonic_tissu | 2.43158149 |
| 12 | MP0008789_abnormal_olfactory_epithelium | 2.38982763 |
| 13 | MP0008775_abnormal_heart_ventricle | 2.33882534 |
| 14 | MP0010030_abnormal_orbit_morphology | 2.31478300 |
| 15 | MP0005360_urolithiasis | 2.23042598 |
| 16 | MP0002796_impaired_skin_barrier | 2.18954355 |
| 17 | MP0001666_abnormal_nutrient_absorption | 2.16321141 |
| 18 | MP0003315_abnormal_perineum_morphology | 2.03426584 |
| 19 | MP0005083_abnormal_biliary_tract | 1.91389507 |
| 20 | MP0003693_abnormal_embryo_hatching | 1.84886750 |
| 21 | MP0000427_abnormal_hair_cycle | 1.78091151 |
| 22 | MP0003786_premature_aging | 1.77839026 |
| 23 | MP0004957_abnormal_blastocyst_morpholog | 1.76308652 |
| 24 | MP0000537_abnormal_urethra_morphology | 1.70439727 |
| 25 | MP0010352_gastrointestinal_tract_polyps | 1.66607270 |
| 26 | MP0005501_abnormal_skin_physiology | 1.63513150 |
| 27 | MP0005670_abnormal_white_adipose | 1.58624241 |
| 28 | MP0010678_abnormal_skin_adnexa | 1.56569017 |
| 29 | MP0000358_abnormal_cell_content/ | 1.49748895 |
| 30 | MP0008932_abnormal_embryonic_tissue | 1.43919517 |
| 31 | MP0001905_abnormal_dopamine_level | 1.40745064 |
| 32 | MP0002751_abnormal_autonomic_nervous | 1.40661852 |
| 33 | MP0008875_abnormal_xenobiotic_pharmacok | 1.39572544 |
| 34 | MP0002060_abnormal_skin_morphology | 1.37509390 |
| 35 | MP0005165_increased_susceptibility_to | 1.34251043 |
| 36 | MP0005365_abnormal_bile_salt | 1.33555201 |
| 37 | MP0003566_abnormal_cell_adhesion | 1.32539841 |
| 38 | MP0001664_abnormal_digestion | 1.32238946 |
| 39 | MP0002332_abnormal_exercise_endurance | 1.31545382 |
| 40 | MP0005394_taste/olfaction_phenotype | 1.31249531 |
| 41 | MP0005499_abnormal_olfactory_system | 1.31249531 |
| 42 | MP0000613_abnormal_salivary_gland | 1.29111343 |
| 43 | MP0002163_abnormal_gland_morphology | 1.26632804 |
| 44 | MP0006035_abnormal_mitochondrial_morpho | 1.25731956 |
| 45 | MP0000750_abnormal_muscle_regeneration | 1.23979833 |
| 46 | MP0003191_abnormal_cellular_cholesterol | 1.23966521 |
| 47 | MP0003950_abnormal_plasma_membrane | 1.20148196 |
| 48 | MP0002938_white_spotting | 1.17647856 |
| 49 | MP0010771_integument_phenotype | 1.16584768 |
| 50 | MP0006054_spinal_hemorrhage | 1.16264351 |
| 51 | MP0004272_abnormal_basement_membrane | 1.13174429 |
| 52 | MP0000383_abnormal_hair_follicle | 1.10589444 |
| 53 | MP0002177_abnormal_outer_ear | 1.09583631 |
| 54 | MP0001243_abnormal_dermal_layer | 1.06654706 |
| 55 | MP0001529_abnormal_vocalization | 1.05996037 |
| 56 | MP0003121_genomic_imprinting | 1.04059939 |
| 57 | MP0000762_abnormal_tongue_morphology | 1.03547174 |
| 58 | MP0005084_abnormal_gallbladder_morpholo | 1.02872697 |
| 59 | MP0005330_cardiomyopathy | 1.01963768 |
| 60 | MP0009840_abnormal_foam_cell | 1.00114230 |
| 61 | MP0001216_abnormal_epidermal_layer | 0.97056826 |
| 62 | MP0006036_abnormal_mitochondrial_physio | 0.96836564 |
| 63 | MP0001730_embryonic_growth_arrest | 0.96213686 |
| 64 | MP0003943_abnormal_hepatobiliary_system | 0.95237868 |
| 65 | MP0000462_abnormal_digestive_system | 0.94680298 |
| 66 | MP0005395_other_phenotype | 0.93645096 |
| 67 | MP0006276_abnormal_autonomic_nervous | 0.92187084 |
| 68 | MP0001756_abnormal_urination | 0.91871726 |
| 69 | MP0002653_abnormal_ependyma_morphology | 0.91029324 |
| 70 | MP0005058_abnormal_lysosome_morphology | 0.90896507 |
| 71 | MP0001340_abnormal_eyelid_morphology | 0.90803002 |
| 72 | MP0003119_abnormal_digestive_system | 0.89648115 |
| 73 | MP0003638_abnormal_response/metabolism_ | 0.87767423 |
| 74 | MP0003942_abnormal_urinary_system | 0.87003925 |
| 75 | MP0008260_abnormal_autophagy | 0.85728623 |
| 76 | MP0006292_abnormal_olfactory_placode | 0.84283552 |
| 77 | MP0001346_abnormal_lacrimal_gland | 0.83121580 |
| 78 | MP0000377_abnormal_hair_follicle | 0.82672472 |
| 79 | MP0008872_abnormal_physiological_respon | 0.80626528 |
| 80 | MP0005380_embryogenesis_phenotype | 0.76747100 |
| 81 | MP0001672_abnormal_embryogenesis/_devel | 0.76747100 |
| 82 | MP0002080_prenatal_lethality | 0.76700221 |
| 83 | MP0002098_abnormal_vibrissa_morphology | 0.76222099 |
| 84 | MP0001293_anophthalmia | 0.73982758 |
| 85 | MP0002970_abnormal_white_adipose | 0.73897942 |
| 86 | MP0003787_abnormal_imprinting | 0.73682013 |
| 87 | MP0003984_embryonic_growth_retardation | 0.72898953 |
| 88 | MP0001542_abnormal_bone_strength | 0.72352851 |
| 89 | MP0001697_abnormal_embryo_size | 0.72088350 |
| 90 | MP0005187_abnormal_penis_morphology | 0.70213354 |
| 91 | MP0004147_increased_porphyrin_level | 0.68299592 |
| 92 | MP0002088_abnormal_embryonic_growth/wei | 0.67629091 |
| 93 | MP0005452_abnormal_adipose_tissue | 0.67088234 |
| 94 | MP0003111_abnormal_nucleus_morphology | 0.65246921 |
| 95 | MP0005646_abnormal_pituitary_gland | 0.64119213 |
| 96 | MP0009053_abnormal_anal_canal | 0.62790805 |
| 97 | MP0002095_abnormal_skin_pigmentation | 0.62728374 |
| 98 | MP0002909_abnormal_adrenal_gland | 0.62336309 |
| 99 | MP0000747_muscle_weakness | 0.61249772 |
| 100 | MP0004185_abnormal_adipocyte_glucose | 0.60755633 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Adrenal hypoplasia (HP:0000835) | 4.65403712 |
| 2 | Vascular calcification (HP:0004934) | 3.94007233 |
| 3 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.71578958 |
| 4 | Upper limb muscle weakness (HP:0003484) | 3.62806404 |
| 5 | Microretrognathia (HP:0000308) | 3.51521072 |
| 6 | Cardiovascular calcification (HP:0011915) | 3.31120205 |
| 7 | Delayed CNS myelination (HP:0002188) | 3.16719784 |
| 8 | Microglossia (HP:0000171) | 3.15536513 |
| 9 | Sparse eyelashes (HP:0000653) | 3.12084383 |
| 10 | Glucose intolerance (HP:0000833) | 3.01797615 |
| 11 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.98819139 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 2.86744397 |
| 13 | Distal lower limb muscle weakness (HP:0009053) | 2.85439561 |
| 14 | Type I transferrin isoform profile (HP:0003642) | 2.81848322 |
| 15 | Right ventricular cardiomyopathy (HP:0011663) | 2.80369833 |
| 16 | Rough bone trabeculation (HP:0100670) | 2.72434392 |
| 17 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.68232298 |
| 18 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.68232298 |
| 19 | Abnormal protein glycosylation (HP:0012346) | 2.68232298 |
| 20 | Abnormal glycosylation (HP:0012345) | 2.68232298 |
| 21 | Hepatic necrosis (HP:0002605) | 2.67359148 |
| 22 | Acute encephalopathy (HP:0006846) | 2.67100578 |
| 23 | Entropion (HP:0000621) | 2.66752814 |
| 24 | Hand muscle atrophy (HP:0009130) | 2.64035529 |
| 25 | Prolonged neonatal jaundice (HP:0006579) | 2.59316368 |
| 26 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.58598010 |
| 27 | Abnormality of glycolysis (HP:0004366) | 2.57000327 |
| 28 | Hepatocellular necrosis (HP:0001404) | 2.50596709 |
| 29 | Increased serum pyruvate (HP:0003542) | 2.47403064 |
| 30 | Micronodular cirrhosis (HP:0001413) | 2.46808630 |
| 31 | Mitochondrial inheritance (HP:0001427) | 2.45479919 |
| 32 | Progressive macrocephaly (HP:0004481) | 2.43467937 |
| 33 | Tongue fasciculations (HP:0001308) | 2.43429394 |
| 34 | Alopecia of scalp (HP:0002293) | 2.41261100 |
| 35 | Distal upper limb amyotrophy (HP:0007149) | 2.37388919 |
| 36 | Upper limb amyotrophy (HP:0009129) | 2.37388919 |
| 37 | Cholecystitis (HP:0001082) | 2.34056846 |
| 38 | Abnormal gallbladder physiology (HP:0012438) | 2.34056846 |
| 39 | Short nail (HP:0001799) | 2.29451649 |
| 40 | Unilateral renal agenesis (HP:0000122) | 2.28102363 |
| 41 | Secondary amenorrhea (HP:0000869) | 2.24837691 |
| 42 | Spastic paraparesis (HP:0002313) | 2.23091542 |
| 43 | Distal lower limb amyotrophy (HP:0008944) | 2.22483424 |
| 44 | Severe muscular hypotonia (HP:0006829) | 2.17784990 |
| 45 | Tetraparesis (HP:0002273) | 2.15635890 |
| 46 | Hyperphosphatemia (HP:0002905) | 2.14035963 |
| 47 | Increased CSF lactate (HP:0002490) | 2.13820511 |
| 48 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.10992599 |
| 49 | Reduced antithrombin III activity (HP:0001976) | 2.10419099 |
| 50 | Hypoplasia of the pons (HP:0012110) | 2.10392738 |
| 51 | Amyloidosis (HP:0011034) | 2.10082834 |
| 52 | Muscle fibrillation (HP:0010546) | 2.07761055 |
| 53 | Bifid uvula (HP:0000193) | 2.07011547 |
| 54 | Progressive hearing impairment (HP:0001730) | 2.04868868 |
| 55 | Limb-girdle muscle atrophy (HP:0003797) | 2.04783874 |
| 56 | Palpitations (HP:0001962) | 2.02970737 |
| 57 | Pili torti (HP:0003777) | 2.01192662 |
| 58 | Progressive muscle weakness (HP:0003323) | 1.99245756 |
| 59 | Hypokinesia (HP:0002375) | 1.97374558 |
| 60 | Abnormality of the pons (HP:0007361) | 1.97144246 |
| 61 | Abnormal trabecular bone morphology (HP:0100671) | 1.95882476 |
| 62 | Opisthotonus (HP:0002179) | 1.95877564 |
| 63 | Steatorrhea (HP:0002570) | 1.93703258 |
| 64 | Anteriorly placed anus (HP:0001545) | 1.91298733 |
| 65 | Heterochromia iridis (HP:0001100) | 1.91010958 |
| 66 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.90760136 |
| 67 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.90760136 |
| 68 | Abnormality of alanine metabolism (HP:0010916) | 1.90549321 |
| 69 | Hyperalaninemia (HP:0003348) | 1.90549321 |
| 70 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.90549321 |
| 71 | Insulin resistance (HP:0000855) | 1.90525281 |
| 72 | Nausea (HP:0002018) | 1.89152897 |
| 73 | Generalized aminoaciduria (HP:0002909) | 1.88598689 |
| 74 | Fasciculations (HP:0002380) | 1.87301857 |
| 75 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.87121405 |
| 76 | Acanthosis nigricans (HP:0000956) | 1.87096716 |
| 77 | Paraparesis (HP:0002385) | 1.86845800 |
| 78 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.86728376 |
| 79 | Short 1st metacarpal (HP:0010034) | 1.86728376 |
| 80 | Cerebral hypomyelination (HP:0006808) | 1.85118514 |
| 81 | Increased serum lactate (HP:0002151) | 1.84607117 |
| 82 | J-shaped sella turcica (HP:0002680) | 1.83190568 |
| 83 | Bradycardia (HP:0001662) | 1.82918148 |
| 84 | Abnormal glucose tolerance (HP:0001952) | 1.81979886 |
| 85 | Median cleft lip (HP:0000161) | 1.81828722 |
| 86 | Cerebellar dysplasia (HP:0007033) | 1.80906077 |
| 87 | Exercise intolerance (HP:0003546) | 1.80818164 |
| 88 | Shoulder girdle muscle weakness (HP:0003547) | 1.80001518 |
| 89 | Abnormality of the sella turcica (HP:0002679) | 1.79360185 |
| 90 | Proximal placement of thumb (HP:0009623) | 1.76734915 |
| 91 | Septate vagina (HP:0001153) | 1.76671335 |
| 92 | Premature rupture of membranes (HP:0001788) | 1.76461773 |
| 93 | Difficulty climbing stairs (HP:0003551) | 1.75447930 |
| 94 | Hypoplasia of the fovea (HP:0007750) | 1.75088271 |
| 95 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.75088271 |
| 96 | Abnormality of the umbilical cord (HP:0010881) | 1.74599691 |
| 97 | Respiratory failure (HP:0002878) | 1.74264464 |
| 98 | Hypoplasia of the uterus (HP:0000013) | 1.73026962 |
| 99 | Hypergonadotropic hypogonadism (HP:0000815) | 1.71052064 |
| 100 | Vertebral compression fractures (HP:0002953) | 1.70383119 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA2 | 5.56119319 |
| 2 | TESK1 | 4.74749831 |
| 3 | NME2 | 4.59630042 |
| 4 | TESK2 | 3.71175349 |
| 5 | LMTK2 | 3.57094130 |
| 6 | LIMK1 | 3.54892989 |
| 7 | VRK2 | 3.33484973 |
| 8 | MST4 | 3.17345673 |
| 9 | MST1R | 2.73203073 |
| 10 | MAP3K12 | 2.11986433 |
| 11 | PBK | 1.96665185 |
| 12 | PAK4 | 1.73394777 |
| 13 | PHKG1 | 1.67449197 |
| 14 | PHKG2 | 1.67449197 |
| 15 | MAP2K7 | 1.56601719 |
| 16 | NEK1 | 1.54299968 |
| 17 | ARAF | 1.52091867 |
| 18 | DAPK1 | 1.51957713 |
| 19 | MAPKAPK3 | 1.51369147 |
| 20 | SCYL2 | 1.51258263 |
| 21 | TLK1 | 1.51157058 |
| 22 | PTK2B | 1.46475587 |
| 23 | BUB1 | 1.45647093 |
| 24 | MET | 1.39766698 |
| 25 | EIF2AK1 | 1.34636128 |
| 26 | CSNK1G3 | 1.33019425 |
| 27 | AURKA | 1.32033046 |
| 28 | PIM2 | 1.30540829 |
| 29 | MOS | 1.28547415 |
| 30 | BCKDK | 1.27562115 |
| 31 | ILK | 1.21772383 |
| 32 | RPS6KB2 | 1.13638408 |
| 33 | CSNK1G2 | 1.12890980 |
| 34 | BRSK1 | 1.08139579 |
| 35 | VRK1 | 1.07317796 |
| 36 | ABL2 | 1.05839344 |
| 37 | CSNK1A1L | 1.03546535 |
| 38 | FER | 1.00610344 |
| 39 | PDK2 | 0.99375250 |
| 40 | PTK2 | 0.98256828 |
| 41 | NEK9 | 0.98079803 |
| 42 | MYLK | 0.96878048 |
| 43 | CSNK1G1 | 0.93677843 |
| 44 | PRKCI | 0.88432822 |
| 45 | STK10 | 0.88129568 |
| 46 | TAOK2 | 0.83686412 |
| 47 | KDR | 0.82936951 |
| 48 | ERBB4 | 0.79395826 |
| 49 | CDK19 | 0.77536511 |
| 50 | ERN1 | 0.74129562 |
| 51 | NME1 | 0.73388398 |
| 52 | DAPK2 | 0.66422877 |
| 53 | AKT2 | 0.64893748 |
| 54 | CDK12 | 0.63233959 |
| 55 | DAPK3 | 0.62655739 |
| 56 | STK16 | 0.60677875 |
| 57 | CAMK2D | 0.57919189 |
| 58 | PAK1 | 0.56640954 |
| 59 | PTK6 | 0.55532460 |
| 60 | MAP3K1 | 0.54294868 |
| 61 | CAMK2G | 0.53632829 |
| 62 | ERBB2 | 0.50622581 |
| 63 | LATS2 | 0.50553691 |
| 64 | MAP3K8 | 0.49824691 |
| 65 | ROCK1 | 0.49648977 |
| 66 | ZAK | 0.48017031 |
| 67 | OXSR1 | 0.46406193 |
| 68 | SRPK1 | 0.42506052 |
| 69 | LRRK2 | 0.42197869 |
| 70 | AURKB | 0.41017213 |
| 71 | PRKG2 | 0.40488421 |
| 72 | MUSK | 0.40276225 |
| 73 | BMX | 0.37517912 |
| 74 | MAP2K2 | 0.37074334 |
| 75 | TRIB3 | 0.37012298 |
| 76 | IRAK3 | 0.37006796 |
| 77 | CDK7 | 0.35561493 |
| 78 | EPHB1 | 0.35450969 |
| 79 | PLK1 | 0.34271708 |
| 80 | MAP3K3 | 0.33325327 |
| 81 | EPHB2 | 0.33228393 |
| 82 | PRKCE | 0.32702182 |
| 83 | EIF2AK3 | 0.31768348 |
| 84 | CCNB1 | 0.31247831 |
| 85 | BRD4 | 0.29829343 |
| 86 | FGFR2 | 0.29035197 |
| 87 | ADRBK1 | 0.27804549 |
| 88 | SIK3 | 0.27775625 |
| 89 | ROCK2 | 0.27604293 |
| 90 | TBK1 | 0.27441288 |
| 91 | GRK1 | 0.27236278 |
| 92 | EPHA4 | 0.26650189 |
| 93 | PRKD2 | 0.26181556 |
| 94 | SIK1 | 0.25838847 |
| 95 | TRIM28 | 0.25815420 |
| 96 | INSRR | 0.25788030 |
| 97 | CSNK1A1 | 0.25435551 |
| 98 | PRKD1 | 0.25233794 |
| 99 | CDK14 | 0.24958385 |
| 100 | PKN2 | 0.24805470 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.71738644 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.63048962 |
| 3 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.34286052 |
| 4 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.31022845 |
| 5 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.27163838 |
| 6 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.26371624 |
| 7 | Glutathione metabolism_Homo sapiens_hsa00480 | 2.23199047 |
| 8 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 2.18843940 |
| 9 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 2.15250314 |
| 10 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 2.11588431 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.10221205 |
| 12 | Sulfur relay system_Homo sapiens_hsa04122 | 1.95537565 |
| 13 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.83558110 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 1.81816303 |
| 15 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.80568499 |
| 16 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.66518335 |
| 17 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.64102350 |
| 18 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.60421072 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.59985584 |
| 20 | DNA replication_Homo sapiens_hsa03030 | 1.53217410 |
| 21 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.53065208 |
| 22 | Galactose metabolism_Homo sapiens_hsa00052 | 1.52834191 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.52732748 |
| 24 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.52698221 |
| 25 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.48835013 |
| 26 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.46386084 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.44455693 |
| 28 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.44321512 |
| 29 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.42855539 |
| 30 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.37966720 |
| 31 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.33325543 |
| 32 | RNA polymerase_Homo sapiens_hsa03020 | 1.29965636 |
| 33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.29211416 |
| 34 | RNA transport_Homo sapiens_hsa03013 | 1.25333784 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.23830123 |
| 36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.22219599 |
| 37 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.18550160 |
| 38 | Ribosome_Homo sapiens_hsa03010 | 1.18341675 |
| 39 | Base excision repair_Homo sapiens_hsa03410 | 1.17758595 |
| 40 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.17394087 |
| 41 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.16969627 |
| 42 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.14922325 |
| 43 | Mismatch repair_Homo sapiens_hsa03430 | 1.12337838 |
| 44 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.11872362 |
| 45 | Carbon metabolism_Homo sapiens_hsa01200 | 1.11871292 |
| 46 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.10084763 |
| 47 | Tight junction_Homo sapiens_hsa04530 | 1.07863207 |
| 48 | Homologous recombination_Homo sapiens_hsa03440 | 1.07693679 |
| 49 | Basal transcription factors_Homo sapiens_hsa03022 | 1.06286120 |
| 50 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.05158066 |
| 51 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.02496825 |
| 52 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.99971663 |
| 53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.97031133 |
| 54 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.92422722 |
| 55 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.90661314 |
| 56 | Purine metabolism_Homo sapiens_hsa00230 | 0.88847359 |
| 57 | Salivary secretion_Homo sapiens_hsa04970 | 0.86939512 |
| 58 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.83078127 |
| 59 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.82610065 |
| 60 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.81652383 |
| 61 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.72009354 |
| 62 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.71923672 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.71891170 |
| 64 | Circadian rhythm_Homo sapiens_hsa04710 | 0.71469117 |
| 65 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.69023660 |
| 66 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.67076402 |
| 67 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.64676148 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.64547381 |
| 69 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.63382821 |
| 70 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.62419360 |
| 71 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.62233150 |
| 72 | Other glycan degradation_Homo sapiens_hsa00511 | 0.62194853 |
| 73 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.61733374 |
| 74 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.61077734 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.60675497 |
| 76 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.60112935 |
| 77 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.58585732 |
| 78 | Endocytosis_Homo sapiens_hsa04144 | 0.58022545 |
| 79 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.57479345 |
| 80 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.54038484 |
| 81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.50600436 |
| 82 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49075642 |
| 83 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48238940 |
| 84 | Shigellosis_Homo sapiens_hsa05131 | 0.47204742 |
| 85 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.46839550 |
| 86 | Lysosome_Homo sapiens_hsa04142 | 0.46829800 |
| 87 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.45507863 |
| 88 | Lysine degradation_Homo sapiens_hsa00310 | 0.44481187 |
| 89 | Thyroid cancer_Homo sapiens_hsa05216 | 0.43606318 |
| 90 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.41275829 |
| 91 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.37683010 |
| 92 | Alcoholism_Homo sapiens_hsa05034 | 0.36909746 |
| 93 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36003873 |
| 94 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.35718035 |
| 95 | Adherens junction_Homo sapiens_hsa04520 | 0.35568937 |
| 96 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.32420072 |
| 97 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.31606968 |
| 98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.31543528 |
| 99 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.29215658 |
| 100 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.26829544 |

