ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	polyketide metabolic process (GO:0030638)	5.61591094
2	doxorubicin metabolic process (GO:0044598)	5.61591094
3	daunorubicin metabolic process (GO:0044597)	5.61591094
4	aminoglycoside antibiotic metabolic process (GO:0030647)	4.99432008
5	glyoxylate metabolic process (GO:0046487)	4.98974406
6	artery smooth muscle contraction (GO:0014824)	4.74135923
7	GDP-mannose metabolic process (GO:0019673)	4.55433550
8	proteasome assembly (GO:0043248)	4.53077985
9	L-phenylalanine metabolic process (GO:0006558)	4.48306542
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.48306542
11	tonic smooth muscle contraction (GO:0014820)	3.98355859
12	phenylpropanoid metabolic process (GO:0009698)	3.94131863
13	growth hormone secretion (GO:0030252)	3.84330140
14	serine family amino acid catabolic process (GO:0009071)	3.58455841
15	glycoside metabolic process (GO:0016137)	3.45621192
16	NADH metabolic process (GO:0006734)	3.44933572
17	regulation of cellular amino acid metabolic process (GO:0006521)	3.44313223
18	serine family amino acid metabolic process (GO:0009069)	3.40848418
19	response to food (GO:0032094)	3.38005100
20	adult feeding behavior (GO:0008343)	3.37689564
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.36870092
22	L-phenylalanine catabolic process (GO:0006559)	3.36870092
23	prostaglandin biosynthetic process (GO:0001516)	3.35023521
24	prostanoid biosynthetic process (GO:0046457)	3.35023521
25	xenobiotic catabolic process (GO:0042178)	3.32760285
26	regulation of cardioblast differentiation (GO:0051890)	3.28776159
27	primary alcohol catabolic process (GO:0034310)	3.28467360
28	cysteine metabolic process (GO:0006534)	3.27127160
29	glucuronate metabolic process (GO:0019585)	3.26810145
30	uronic acid metabolic process (GO:0006063)	3.26810145
31	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.25544150
32	nucleotide-sugar biosynthetic process (GO:0009226)	3.25286627
33	peroxisome fission (GO:0016559)	3.24370071
34	cobalamin metabolic process (GO:0009235)	3.23104305
35	ribosomal large subunit biogenesis (GO:0042273)	3.22324754
36	cellular glucuronidation (GO:0052695)	3.19842162
37	glycine metabolic process (GO:0006544)	3.19814464
38	L-serine metabolic process (GO:0006563)	3.19442172
39	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.18451410
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.16169867
41	serine family amino acid biosynthetic process (GO:0009070)	3.13489910
42	nucleoside transmembrane transport (GO:1901642)	3.12117051
43	protein retention in ER lumen (GO:0006621)	3.10666503
44	protein autoprocessing (GO:0016540)	3.09443674
45	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.08599978
46	urea cycle (GO:0000050)	3.05275558
47	epoxygenase P450 pathway (GO:0019373)	3.03199485
48	ATP synthesis coupled proton transport (GO:0015986)	3.01636230
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.01636230
50	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.00936477
51	prostaglandin metabolic process (GO:0006693)	2.97448349
52	prostanoid metabolic process (GO:0006692)	2.97448349
53	glutathione derivative metabolic process (GO:1901685)	2.96104660
54	glutathione derivative biosynthetic process (GO:1901687)	2.96104660
55	cyclooxygenase pathway (GO:0019371)	2.94178704
56	quinone metabolic process (GO:1901661)	2.92602502
57	desmosome organization (GO:0002934)	2.91805468
58	urea metabolic process (GO:0019627)	2.89918334
59	regulation of triglyceride catabolic process (GO:0010896)	2.88251989
60	glucose 6-phosphate metabolic process (GO:0051156)	2.87248589
61	cellular aldehyde metabolic process (GO:0006081)	2.87081780
62	regulation of mitochondrial translation (GO:0070129)	2.85812442
63	proline metabolic process (GO:0006560)	2.85546384
64	mitochondrial fusion (GO:0008053)	2.84373329
65	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84252404
66	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83410692
67	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77513859
68	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77513859
69	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.74842106
70	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.74842106
71	chaperone-mediated protein transport (GO:0072321)	2.73040638
72	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.72137717
73	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.72137717
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.72137717
75	regulation of cellular amine metabolic process (GO:0033238)	2.71716729
76	intestinal absorption (GO:0050892)	2.71279979
77	digestion (GO:0007586)	2.71029068
78	protein carboxylation (GO:0018214)	2.70151839
79	peptidyl-glutamic acid carboxylation (GO:0017187)	2.70151839
80	negative regulation of epidermal cell differentiation (GO:0045605)	2.70080937
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.69903234
82	formation of translation preinitiation complex (GO:0001731)	2.69831491
83	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.69742140
84	positive regulation of cellular amine metabolic process (GO:0033240)	2.69407959
85	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68006914
86	homocysteine metabolic process (GO:0050667)	2.67548377
87	negative regulation of ligase activity (GO:0051352)	2.66978100
88	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66978100
89	aldehyde catabolic process (GO:0046185)	2.66932767
90	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64965101
91	L-alpha-amino acid transmembrane transport (GO:1902475)	2.64943938
92	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.64593382
93	ATP hydrolysis coupled proton transport (GO:0015991)	2.64593382
94	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.61803767
95	glutamine family amino acid biosynthetic process (GO:0009084)	2.60198579
96	nucleoside transport (GO:0015858)	2.58915096
97	rRNA modification (GO:0000154)	2.57444885
98	sulfur amino acid catabolic process (GO:0000098)	2.56439930
99	tricarboxylic acid cycle (GO:0006099)	2.56042110
100	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.53702870

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.79815611
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.66778895
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.54588380
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.21558876
5	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.13053227
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.08445709
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.08115081
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.98824758
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.89313823
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.83684973
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67001977
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.55114583
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.54636210
14	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.45453300
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.44413142
16	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.39967120
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30521616
18	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.30160874
19	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.08891126
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.03607020
21	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.02938148
22	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.99940084
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.98787016
24	ZNF263_19887448_ChIP-Seq_K562_Human	1.96707210
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.96485994
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.93332710
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.91129250
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.87359745
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.80527646
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.79052081
31	XRN2_22483619_ChIP-Seq_HELA_Human	1.78182556
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.78171896
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74196629
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.73731170
35	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.72824207
36	AR_21909140_ChIP-Seq_LNCAP_Human	1.69573980
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.67502055
38	GATA4_25053715_ChIP-Seq_YYC3_Human	1.64099239
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.63825377
40	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.62948755
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59380201
42	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.58452097
43	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.57934944
44	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.54491026
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52549309
46	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.52253387
47	GATA6_25053715_ChIP-Seq_YYC3_Human	1.51851924
48	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.51411080
49	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.44584399
50	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.41911201
51	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.39134816
52	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.37290522
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33039710
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.31665234
55	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.29619392
56	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.28761203
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.28309009
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27568851
59	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.23528586
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23031186
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22270609
62	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.21871477
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.21699318
64	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.19844531
65	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.18540993
66	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.18145549
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.15228578
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.14572714
69	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.12344392
70	E2F7_22180533_ChIP-Seq_HELA_Human	1.12201283
71	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.11952062
72	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11047566
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.08602514
74	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.08008724
75	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07046026
76	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.05103820
77	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04686529
78	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04317348
79	RACK7_27058665_Chip-Seq_MCF-7_Human	1.03128802
80	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02211388
81	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.01701252
82	PHF8_20622854_ChIP-Seq_HELA_Human	1.01479067
83	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.00410922
84	VDR_23849224_ChIP-Seq_CD4+_Human	1.00329253
85	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.99871834
86	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.99757813
87	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.99664644
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97100572
89	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.96947150
90	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.96925698
91	P68_20966046_ChIP-Seq_HELA_Human	0.96275497
92	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95725806
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95481208
94	SOX2_20726797_ChIP-Seq_SW620_Human	0.94837579
95	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.93996203
96	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.93763242
97	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.93040177
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92764631
99	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.92217074
100	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.91505560

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.96533836
2	MP0005360_urolithiasis	4.65542793
3	MP0001666_abnormal_nutrient_absorption	4.11524324
4	MP0003136_yellow_coat_color	4.01251086
5	MP0003868_abnormal_feces_composition	3.32582669
6	MP0002822_catalepsy	3.11077820
7	MP0003806_abnormal_nucleotide_metabolis	3.10081995
8	MP0003693_abnormal_embryo_hatching	3.02104249
9	MP0005365_abnormal_bile_salt	2.88388126
10	MP0010234_abnormal_vibrissa_follicle	2.82946061
11	MP0008875_abnormal_xenobiotic_pharmacok	2.56136711
12	MP0009840_abnormal_foam_cell	2.34167652
13	MP0005085_abnormal_gallbladder_physiolo	2.31601851
14	MP0002138_abnormal_hepatobiliary_system	2.28202539
15	MP0003718_maternal_effect	2.25105470
16	MP0004019_abnormal_vitamin_homeostasis	2.15699339
17	MP0000537_abnormal_urethra_morphology	2.13311048
18	MP0005451_abnormal_body_composition	2.11503081
19	MP0004147_increased_porphyrin_level	2.11476711
20	MP0004264_abnormal_extraembryonic_tissu	2.03105109
21	MP0002796_impaired_skin_barrier	1.90250733
22	MP0004957_abnormal_blastocyst_morpholog	1.86588476
23	MP0009697_abnormal_copulation	1.85644053
24	MP0008872_abnormal_physiological_respon	1.80939335
25	MP0002938_white_spotting	1.78338728
26	MP0005075_abnormal_melanosome_morpholog	1.77771800
27	MP0003315_abnormal_perineum_morphology	1.75007737
28	MP0000462_abnormal_digestive_system	1.66405284
29	MP0005332_abnormal_amino_acid	1.63709604
30	MP0002163_abnormal_gland_morphology	1.62388155
31	MP0003195_calcinosis	1.61856181
32	MP0005220_abnormal_exocrine_pancreas	1.60587279
33	MP0002876_abnormal_thyroid_physiology	1.56028181
34	MP0005084_abnormal_gallbladder_morpholo	1.51186633
35	MP0010329_abnormal_lipoprotein_level	1.45039985
36	MP0005408_hypopigmentation	1.44972652
37	MP0003186_abnormal_redox_activity	1.44297758
38	MP0009379_abnormal_foot_pigmentation	1.42046986
39	MP0001764_abnormal_homeostasis	1.38702228
40	MP0009643_abnormal_urine_homeostasis	1.38308330
41	MP0000490_abnormal_crypts_of	1.37885174
42	MP0005083_abnormal_biliary_tract	1.37171223
43	MP0001664_abnormal_digestion	1.35654010
44	MP0000538_abnormal_urinary_bladder	1.34408509
45	MP0003119_abnormal_digestive_system	1.33988794
46	MP0002102_abnormal_ear_morphology	1.29917279
47	MP0005058_abnormal_lysosome_morphology	1.26318661
48	MP0005379_endocrine/exocrine_gland_phen	1.22774470
49	MP0006036_abnormal_mitochondrial_physio	1.19878580
50	MP0003959_abnormal_lean_body	1.19388556
51	MP0005636_abnormal_mineral_homeostasis	1.14985870
52	MP0002132_abnormal_respiratory_system	1.14665269
53	MP0000566_synostosis	1.11208698
54	MP0004381_abnormal_hair_follicle	1.10300853
55	MP0005501_abnormal_skin_physiology	1.08933554
56	MP0002098_abnormal_vibrissa_morphology	1.08633595
57	MP0008932_abnormal_embryonic_tissue	1.07967466
58	MP0005319_abnormal_enzyme/_coenzyme	1.05783650
59	MP0006035_abnormal_mitochondrial_morpho	1.02408524
60	MP0001529_abnormal_vocalization	1.01506653
61	MP0003638_abnormal_response/metabolism_	0.99626843
62	MP0001730_embryonic_growth_arrest	0.99272017
63	MP0005410_abnormal_fertilization	0.92815321
64	MP0008058_abnormal_DNA_repair	0.92315864
65	MP0009672_abnormal_birth_weight	0.89761653
66	MP0010094_abnormal_chromosome_stability	0.89573257
67	MP0003941_abnormal_skin_development	0.87003387
68	MP0000647_abnormal_sebaceous_gland	0.86561331
69	MP0002118_abnormal_lipid_homeostasis	0.86182699
70	MP0010030_abnormal_orbit_morphology	0.84432027
71	MP0010352_gastrointestinal_tract_polyps	0.83099185
72	MP0001727_abnormal_embryo_implantation	0.81592083
73	MP0003191_abnormal_cellular_cholesterol	0.77973252
74	MP0010386_abnormal_urinary_bladder	0.77898166
75	MP0004782_abnormal_surfactant_physiolog	0.75065779
76	MP0004272_abnormal_basement_membrane	0.72383805
77	MP0000477_abnormal_intestine_morphology	0.71986563
78	MP0000377_abnormal_hair_follicle	0.71471083
79	MP0001756_abnormal_urination	0.71260426
80	MP0008004_abnormal_stomach_pH	0.68993855
81	MP0003866_abnormal_defecation	0.67581463
82	MP0000609_abnormal_liver_physiology	0.67052972
83	MP0000598_abnormal_liver_morphology	0.66482992
84	MP0003111_abnormal_nucleus_morphology	0.66204375
85	MP0000613_abnormal_salivary_gland	0.65907338
86	MP0005670_abnormal_white_adipose	0.65747509
87	MP0003077_abnormal_cell_cycle	0.64688119
88	MP0002160_abnormal_reproductive_system	0.63965940
89	MP0003953_abnormal_hormone_level	0.63668187
90	MP0001765_abnormal_ion_homeostasis	0.63057024
91	MP0005395_other_phenotype	0.62526221
92	MP0005187_abnormal_penis_morphology	0.60962508
93	MP0005499_abnormal_olfactory_system	0.59536072
94	MP0005394_taste/olfaction_phenotype	0.59536072
95	MP0003937_abnormal_limbs/digits/tail_de	0.58015935
96	MP0009333_abnormal_splenocyte_physiolog	0.57700212
97	MP0000747_muscle_weakness	0.56803503
98	MP0003786_premature_aging	0.56199438
99	MP0005381_digestive/alimentary_phenotyp	0.56095855
100	MP0001216_abnormal_epidermal_layer	0.55125426

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.90705622
2	Hypoglycemic coma (HP:0001325)	3.87947327
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.85332491
4	Hyperglycinemia (HP:0002154)	3.64768096
5	Abnormality of alanine metabolism (HP:0010916)	3.60334138
6	Hyperalaninemia (HP:0003348)	3.60334138
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.60334138
8	Reduced antithrombin III activity (HP:0001976)	3.54487827
9	Abnormality of pyrimidine metabolism (HP:0004353)	3.43590659
10	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.43393904
11	Generalized aminoaciduria (HP:0002909)	3.24211800
12	Hypobetalipoproteinemia (HP:0003563)	3.20123645
13	Deep venous thrombosis (HP:0002625)	3.11977456
14	Hyperammonemia (HP:0001987)	3.09325959
15	Abnormality of serum amino acid levels (HP:0003112)	3.07903407
16	Birth length less than 3rd percentile (HP:0003561)	3.01344971
17	Proximal tubulopathy (HP:0000114)	2.99720584
18	Microvesicular hepatic steatosis (HP:0001414)	2.92440066
19	Rough bone trabeculation (HP:0100670)	2.90194088
20	Glycosuria (HP:0003076)	2.80721897
21	Abnormality of urine glucose concentration (HP:0011016)	2.80721897
22	Hepatic necrosis (HP:0002605)	2.80224175
23	Cholecystitis (HP:0001082)	2.72700190
24	Abnormal gallbladder physiology (HP:0012438)	2.72700190
25	Acute encephalopathy (HP:0006846)	2.72172059
26	Nausea (HP:0002018)	2.65469125
27	Prolonged partial thromboplastin time (HP:0003645)	2.62908293
28	Abnormal trabecular bone morphology (HP:0100671)	2.61511080
29	Lethargy (HP:0001254)	2.58022985
30	Increased serum pyruvate (HP:0003542)	2.54344839
31	Abnormality of serine family amino acid metabolism (HP:0010894)	2.53803027
32	Abnormality of glycine metabolism (HP:0010895)	2.53803027
33	Abnormality of glycolysis (HP:0004366)	2.53798837
34	Late onset (HP:0003584)	2.50208915
35	Abnormality of proline metabolism (HP:0010907)	2.50167609
36	Hydroxyprolinuria (HP:0003080)	2.50167609
37	Hepatocellular necrosis (HP:0001404)	2.45240390
38	Esophageal neoplasm (HP:0100751)	2.42371716
39	Neoplasm of head and neck (HP:0012288)	2.42371716
40	Delayed CNS myelination (HP:0002188)	2.42205512
41	Increased CSF lactate (HP:0002490)	2.41738301
42	Steatorrhea (HP:0002570)	2.39658284
43	Type I transferrin isoform profile (HP:0003642)	2.39433294
44	Amelogenesis imperfecta (HP:0000705)	2.37239334
45	Fat malabsorption (HP:0002630)	2.35849876
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.34363879
47	Vascular calcification (HP:0004934)	2.34103239
48	Hypoglycemic seizures (HP:0002173)	2.33910611
49	Type II lissencephaly (HP:0007260)	2.33421407
50	Hyperinsulinemic hypoglycemia (HP:0000825)	2.32123279
51	Intrahepatic cholestasis (HP:0001406)	2.29187478
52	Lipid accumulation in hepatocytes (HP:0006561)	2.28420508
53	Acute necrotizing encephalopathy (HP:0006965)	2.27208466
54	Dicarboxylic aciduria (HP:0003215)	2.26079388
55	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.26079388
56	Mitochondrial inheritance (HP:0001427)	2.23496928
57	Abnormality of methionine metabolism (HP:0010901)	2.23274478
58	Increased serum lactate (HP:0002151)	2.23214621
59	Tongue fasciculations (HP:0001308)	2.21627303
60	Congenital ichthyosiform erythroderma (HP:0007431)	2.18531319
61	Microretrognathia (HP:0000308)	2.18350343
62	Cerebral edema (HP:0002181)	2.13963976
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.13876217
64	Abnormal protein N-linked glycosylation (HP:0012347)	2.13876217
65	Abnormal protein glycosylation (HP:0012346)	2.13876217
66	Abnormal glycosylation (HP:0012345)	2.13876217
67	CNS demyelination (HP:0007305)	2.13009364
68	Lactic acidosis (HP:0003128)	2.12038319
69	Metabolic acidosis (HP:0001942)	2.12002322
70	Hyperphosphaturia (HP:0003109)	2.10843976
71	Hyperglycinuria (HP:0003108)	2.10591158
72	Limb-girdle muscle atrophy (HP:0003797)	2.10190015
73	Breast hypoplasia (HP:0003187)	2.07520588
74	Symptomatic seizures (HP:0011145)	2.06265486
75	Hyperglycemia (HP:0003074)	2.02105896
76	Ureteral duplication (HP:0000073)	2.00670045
77	Xanthomatosis (HP:0000991)	1.99587235
78	Micronodular cirrhosis (HP:0001413)	1.97655708
79	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97054284
80	Sparse eyelashes (HP:0000653)	1.96445209
81	Ketoacidosis (HP:0001993)	1.95601615
82	Hypolipoproteinemia (HP:0010981)	1.94723466
83	Methylmalonic aciduria (HP:0012120)	1.93940666
84	Abnormal number of erythroid precursors (HP:0012131)	1.88767325
85	Retinal dysplasia (HP:0007973)	1.88479046
86	Brittle hair (HP:0002299)	1.84839744
87	Cardiovascular calcification (HP:0011915)	1.84668319
88	Renal tubular dysfunction (HP:0000124)	1.83868549
89	Vomiting (HP:0002013)	1.83499222
90	Opisthotonus (HP:0002179)	1.82122639
91	Muscle fibrillation (HP:0010546)	1.81590816
92	Neonatal onset (HP:0003623)	1.81582653
93	Increased hepatocellular lipid droplets (HP:0006565)	1.80208711
94	Ketosis (HP:0001946)	1.79538185
95	Shoulder girdle muscle weakness (HP:0003547)	1.78911398
96	Abnormal urine phosphate concentration (HP:0012599)	1.78637423
97	Gonadal dysgenesis (HP:0000133)	1.78028610
98	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76501258
99	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.76273574
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.76273574

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.33065729
2	TLK1	4.02393383
3	BUB1	3.33430675
4	VRK2	3.26462818
5	MST1R	2.96182325
6	MST4	2.89372253
7	ZAK	2.86229339
8	PBK	2.84909208
9	INSRR	2.71693559
10	STK16	2.60558003
11	LMTK2	2.53867482
12	MAP3K12	2.43668225
13	TESK1	2.23627335
14	NME2	2.01337429
15	PDK2	1.82265181
16	SMG1	1.79795464
17	VRK1	1.78375722
18	TRIM28	1.77762788
19	RPS6KB2	1.71577540
20	PAK4	1.68408616
21	NME1	1.67082205
22	LIMK1	1.66983923
23	EIF2AK1	1.56295506
24	STK39	1.55750966
25	SCYL2	1.50885450
26	NEK1	1.40521253
27	RPS6KA5	1.40500535
28	ABL2	1.40331894
29	MYLK	1.28883960
30	BCKDK	1.28862285
31	MAP3K3	1.27639963
32	DAPK3	1.18333425
33	AURKA	1.17120607
34	PTK6	1.13841467
35	DAPK1	1.12494144
36	TESK2	1.10790957
37	AKT2	0.99993770
38	OXSR1	0.94334193
39	AURKB	0.92664165
40	CDK19	0.91637772
41	ARAF	0.90897323
42	TBK1	0.90538002
43	MAPKAPK3	0.90513792
44	TSSK6	0.90198210
45	MET	0.90025569
46	NUAK1	0.86071985
47	SRPK1	0.82489403
48	TAF1	0.81413998
49	MAP3K8	0.80609975
50	CAMK2G	0.78962083
51	ILK	0.78182972
52	PRKCI	0.76099941
53	TAOK1	0.72824058
54	PLK1	0.71809454
55	MAP3K11	0.71028841
56	WNK4	0.70643903
57	ERN1	0.70280756
58	PIM2	0.69054165
59	CSNK1G3	0.68545731
60	CDC7	0.68092631
61	MAP2K2	0.67550167
62	PRKG2	0.65923055
63	STK10	0.65581389
64	EPHB2	0.63914609
65	STK4	0.59682781
66	GRK1	0.59556877
67	MUSK	0.59158585
68	WEE1	0.59074114
69	CDK8	0.57710615
70	CDK9	0.56979475
71	EPHA4	0.55071639
72	MAP2K7	0.54994211
73	EIF2AK3	0.54733387
74	CSNK1A1L	0.54574531
75	NEK2	0.54267914
76	CAMK2D	0.54031783
77	ERBB4	0.52457532
78	PAK1	0.51957903
79	CCNB1	0.50647506
80	RPS6KA4	0.47539403
81	CSNK1A1	0.46523299
82	CDK7	0.45906590
83	BRSK1	0.42661334
84	MAP2K1	0.42367295
85	LATS1	0.42354943
86	CHUK	0.39700619
87	CSNK2A1	0.38605553
88	CHEK2	0.38461243
89	GRK6	0.38408945
90	MAP3K2	0.37763506
91	CSNK1G1	0.35311515
92	SIK1	0.33331133
93	CAMK2B	0.33238458
94	PASK	0.32646291
95	MAP3K9	0.32639894
96	FGFR4	0.32568672
97	PIK3CG	0.31143182
98	CSNK2A2	0.30799453
99	BLK	0.30673221
100	PRKCA	0.27536335

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.08001808
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.59315767
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.42325148
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.39197740
5	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.38713622
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.33474031
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.22461628
8	Sulfur relay system_Homo sapiens_hsa04122	2.14751661
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.13678463
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.12208552
11	Arginine biosynthesis_Homo sapiens_hsa00220	2.12201146
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.08873020
13	Fat digestion and absorption_Homo sapiens_hsa04975	1.97314083
14	Sulfur metabolism_Homo sapiens_hsa00920	1.95944785
15	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.82162342
16	Glutathione metabolism_Homo sapiens_hsa00480	1.77360929
17	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.74647973
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.74247613
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.73075688
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.70216445
21	Carbon metabolism_Homo sapiens_hsa01200	1.65980796
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.65939634
23	Ribosome_Homo sapiens_hsa03010	1.65816115
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.62448289
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.58658457
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.57737882
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.57359585
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.55776998
29	Folate biosynthesis_Homo sapiens_hsa00790	1.51757270
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.47391527
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.44294638
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.43428381
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.42734281
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41969602
35	DNA replication_Homo sapiens_hsa03030	1.39120999
36	Retinol metabolism_Homo sapiens_hsa00830	1.38438207
37	Galactose metabolism_Homo sapiens_hsa00052	1.36511926
38	Parkinsons disease_Homo sapiens_hsa05012	1.36462305
39	Peroxisome_Homo sapiens_hsa04146	1.35433310
40	Fatty acid elongation_Homo sapiens_hsa00062	1.29203020
41	RNA polymerase_Homo sapiens_hsa03020	1.26484683
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.25733642
43	Butanoate metabolism_Homo sapiens_hsa00650	1.22769835
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.20302603
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.19154704
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17131508
47	Mismatch repair_Homo sapiens_hsa03430	1.16051769
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15526364
49	Vibrio cholerae infection_Homo sapiens_hsa05110	1.14442309
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13272230
51	Selenocompound metabolism_Homo sapiens_hsa00450	1.10474972
52	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10227911
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.08350213
54	Tryptophan metabolism_Homo sapiens_hsa00380	1.07353194
55	Pentose phosphate pathway_Homo sapiens_hsa00030	1.02282291
56	Huntingtons disease_Homo sapiens_hsa05016	0.99407723
57	One carbon pool by folate_Homo sapiens_hsa00670	0.97133936
58	Base excision repair_Homo sapiens_hsa03410	0.95095201
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.92618135
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.91563748
61	Metabolic pathways_Homo sapiens_hsa01100	0.91044716
62	Histidine metabolism_Homo sapiens_hsa00340	0.86959713
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.84238952
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83486245
65	Renin-angiotensin system_Homo sapiens_hsa04614	0.82838792
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81363447
67	Fatty acid degradation_Homo sapiens_hsa00071	0.81319224
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.80961937
69	Pancreatic secretion_Homo sapiens_hsa04972	0.77966701
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.77598105
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.76409505
72	Alzheimers disease_Homo sapiens_hsa05010	0.74381159
73	Bile secretion_Homo sapiens_hsa04976	0.73228242
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72581823
75	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70537072
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.70470487
77	Protein digestion and absorption_Homo sapiens_hsa04974	0.70409336
78	Propanoate metabolism_Homo sapiens_hsa00640	0.70348673
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69559239
80	Alcoholism_Homo sapiens_hsa05034	0.69219878
81	Complement and coagulation cascades_Homo sapiens_hsa04610	0.67971638
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.67520101
83	Spliceosome_Homo sapiens_hsa03040	0.63711026
84	Basal transcription factors_Homo sapiens_hsa03022	0.57506238
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.57238840
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56584163
87	Purine metabolism_Homo sapiens_hsa00230	0.56091307
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54785405
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.54454415
90	RNA transport_Homo sapiens_hsa03013	0.53568061
91	Homologous recombination_Homo sapiens_hsa03440	0.53403710
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.51366047
93	Protein export_Homo sapiens_hsa03060	0.50453978
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50289678
95	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50091844
96	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49706358
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.49619200
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48662202
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47574515
100	Mineral absorption_Homo sapiens_hsa04978	0.46594603

KRT8P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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