ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ether lipid metabolic process (GO:0046485)	9.96640625
2	behavioral response to ethanol (GO:0048149)	9.40938939
3	adult feeding behavior (GO:0008343)	8.94161584
4	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	8.93225853
5	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	8.68795300
6	regulation of protein glycosylation (GO:0060049)	7.63438617
7	regulation of acrosome reaction (GO:0060046)	7.62304507
8	sphingosine metabolic process (GO:0006670)	7.40984295
9	diol metabolic process (GO:0034311)	6.99813814
10	positive regulation of cAMP-mediated signaling (GO:0043950)	6.61455896
11	notochord development (GO:0030903)	6.34138081
12	negative regulation of nitric oxide biosynthetic process (GO:0045019)	6.24457878
13	sphingoid metabolic process (GO:0046519)	6.24098890
14	thrombin receptor signaling pathway (GO:0070493)	6.16017257
15	glycerol ether metabolic process (GO:0006662)	6.11503386
16	piRNA metabolic process (GO:0034587)	5.88820236
17	negative regulation of glycoprotein biosynthetic process (GO:0010561)	5.73000710
18	ether metabolic process (GO:0018904)	5.63853870
19	mRNA cleavage (GO:0006379)	5.28200777
20	cellular response to ammonium ion (GO:0071242)	5.09879361
21	DNA replication-dependent nucleosome assembly (GO:0006335)	4.99858198
22	DNA replication-dependent nucleosome organization (GO:0034723)	4.99858198
23	signal complex assembly (GO:0007172)	4.85162878
24	regulation of translational elongation (GO:0006448)	4.35729402
25	cell-cell junction maintenance (GO:0045217)	4.22564287
26	negative regulation of glycoprotein metabolic process (GO:1903019)	4.17893167
27	regulation of glutamate receptor signaling pathway (GO:1900449)	4.16749614
28	ncRNA catabolic process (GO:0034661)	4.13088527
29	epoxygenase P450 pathway (GO:0019373)	4.11935557
30	regulation of cAMP-mediated signaling (GO:0043949)	3.96972224
31	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.96936898
32	negative regulation of cell-matrix adhesion (GO:0001953)	3.80738642
33	N-terminal protein amino acid acetylation (GO:0006474)	3.73062661
34	omega-hydroxylase P450 pathway (GO:0097267)	3.72755319
35	glomerular visceral epithelial cell development (GO:0072015)	3.71922639
36	glycosphingolipid metabolic process (GO:0006687)	3.66042398
37	glucose catabolic process (GO:0006007)	3.57793150
38	cellular response to alkaloid (GO:0071312)	3.55407223
39	vitamin catabolic process (GO:0009111)	3.55230417
40	fat-soluble vitamin catabolic process (GO:0042363)	3.55230417
41	pyrimidine dimer repair (GO:0006290)	3.50984543
42	coenzyme catabolic process (GO:0009109)	3.48857578
43	cell junction maintenance (GO:0034331)	3.39823830
44	interferon-gamma secretion (GO:0072643)	3.38838468
45	wound healing, spreading of epidermal cells (GO:0035313)	3.36614922
46	quinone biosynthetic process (GO:1901663)	3.34193430
47	establishment of skin barrier (GO:0061436)	3.32811603
48	epithelial cell-cell adhesion (GO:0090136)	3.30675475
49	lung secretory cell differentiation (GO:0061140)	3.28539179
50	cornea development in camera-type eye (GO:0061303)	3.27023262
51	viral mRNA export from host cell nucleus (GO:0046784)	3.22947384
52	dopamine receptor signaling pathway (GO:0007212)	3.21207644
53	glomerular epithelial cell development (GO:0072310)	3.21172943
54	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.09786409
55	negative regulation of cyclase activity (GO:0031280)	3.07443666
56	membrane lipid metabolic process (GO:0006643)	3.06130604
57	regulation of water loss via skin (GO:0033561)	3.05202793
58	regulation of female receptivity (GO:0045924)	3.03725506
59	regulation of odontogenesis (GO:0042481)	2.99199297
60	female mating behavior (GO:0060180)	2.97912272
61	multicellular organismal water homeostasis (GO:0050891)	2.96560513
62	fat-soluble vitamin biosynthetic process (GO:0042362)	2.94983445
63	glycolipid metabolic process (GO:0006664)	2.93960278
64	positive regulation of protein complex disassembly (GO:0043243)	2.93017101
65	negative regulation of adenylate cyclase activity (GO:0007194)	2.92021625
66	negative regulation of lyase activity (GO:0051350)	2.87907419
67	quinone metabolic process (GO:1901661)	2.84919143
68	chemical homeostasis within a tissue (GO:0048875)	2.81753415
69	regulation of glycoprotein biosynthetic process (GO:0010559)	2.79145693
70	response to morphine (GO:0043278)	2.78529742
71	negative regulation of exocytosis (GO:0045920)	2.78189978
72	liposaccharide metabolic process (GO:1903509)	2.76741474
73	sphingolipid metabolic process (GO:0006665)	2.76407142
74	positive regulation of nitric oxide biosynthetic process (GO:0045429)	2.75281892
75	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.73011966
76	positive regulation of icosanoid secretion (GO:0032305)	2.69486129
77	DNA synthesis involved in DNA repair (GO:0000731)	2.69044294
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.64190736
79	phospholipid efflux (GO:0033700)	2.63443080
80	thyroid hormone generation (GO:0006590)	2.61927122
81	surfactant homeostasis (GO:0043129)	2.59877728
82	response to isoquinoline alkaloid (GO:0014072)	2.59712186
83	hexose catabolic process (GO:0019320)	2.56810236
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55338196
85	polyol biosynthetic process (GO:0046173)	2.55030063
86	positive regulation of fatty acid transport (GO:2000193)	2.54891240
87	hepatocyte apoptotic process (GO:0097284)	2.54572526
88	GMP metabolic process (GO:0046037)	2.53216453
89	regulation of guanylate cyclase activity (GO:0031282)	2.51828102
90	urate metabolic process (GO:0046415)	2.51700824
91	renal system process involved in regulation of blood volume (GO:0001977)	2.48903923
92	regulation of bile acid biosynthetic process (GO:0070857)	2.47426707
93	actin filament depolymerization (GO:0030042)	2.47003599
94	nucleoside transmembrane transport (GO:1901642)	2.46660049
95	negative regulation of keratinocyte proliferation (GO:0010839)	2.46156486
96	ribonucleoprotein complex disassembly (GO:0032988)	2.45252780
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	13.9019347
98	negative regulation of cAMP-mediated signaling (GO:0043951)	11.6760712
99	regulation of translational termination (GO:0006449)	11.2757102
100	opioid receptor signaling pathway (GO:0038003)	10.9709994

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.00076842
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.87868452
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.87636397
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.35989155
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.31948981
6	EGR1_19032775_ChIP-ChIP_M12_Human	2.82130533
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.81655970
8	AR_21909140_ChIP-Seq_LNCAP_Human	2.69796476
9	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.67838426
10	RXR_22108803_ChIP-Seq_LS180_Human	2.67652844
11	VDR_22108803_ChIP-Seq_LS180_Human	2.62061715
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61407156
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.61407156
14	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.53569595
15	HTT_18923047_ChIP-ChIP_STHdh_Human	2.46007314
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.44499992
17	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.32372412
18	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.31840459
19	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.20920428
20	GATA6_25053715_ChIP-Seq_YYC3_Human	2.20439251
21	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.17618070
22	GATA4_25053715_ChIP-Seq_YYC3_Human	2.13851416
23	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.95314388
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87853905
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.85038229
26	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.82646944
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.81931380
28	NANOG_20526341_ChIP-Seq_ESCs_Human	1.77575498
29	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.75539685
30	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.73778878
31	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.67224806
32	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.63348913
33	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.60540346
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.55578871
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.55578871
36	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.52520800
37	ELF5_23300383_ChIP-Seq_T47D_Human	1.51257413
38	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.49518835
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.46026511
40	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.42229669
41	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.39227275
42	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36401748
43	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.32505986
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30389742
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.28533734
46	CEBPB_22108803_ChIP-Seq_LS180_Human	1.26943738
47	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26709534
48	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.25135299
49	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.23768969
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23730698
51	TAF15_26573619_Chip-Seq_HEK293_Human	1.23597480
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.23591888
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23591888
54	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.22597590
55	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.21370352
56	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21151618
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20227785
58	RAC3_21632823_ChIP-Seq_H3396_Human	1.20093314
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19641104
60	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18437806
61	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.18155138
62	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.17727422
63	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.16790185
64	CDX2_22108803_ChIP-Seq_LS180_Human	1.15962027
65	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.14958559
66	ERA_21632823_ChIP-Seq_H3396_Human	1.13842028
67	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.12962963
68	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09312418
69	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.09273412
70	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.08461633
71	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08194330
72	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07118181
73	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.06210645
74	E2F1_20622854_ChIP-Seq_HELA_Human	1.04750810
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02973003
76	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.00020371
77	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.99787105
78	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.97248266
79	BCAT_22108803_ChIP-Seq_LS180_Human	0.97241625
80	CBP_21632823_ChIP-Seq_H3396_Human	0.94761808
81	STAT1_20625510_ChIP-Seq_HELA_Human	0.93946912
82	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.92775402
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92769145
84	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.92744011
85	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.92461852
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91066314
87	SOX2_20726797_ChIP-Seq_SW620_Human	0.90041661
88	ATF3_27146783_Chip-Seq_COLON_Human	0.89882744
89	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.89300723
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.88411250
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.87959794
92	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.86175432
93	PHF8_20622854_ChIP-Seq_HELA_Human	0.85731394
94	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.85571208
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84981844
96	RACK7_27058665_Chip-Seq_MCF-7_Human	0.84978446
97	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.84430092
98	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84212993
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.83984192
100	BCOR_27268052_Chip-Seq_Bcells_Human	0.81757294

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	6.35777730
2	MP0005360_urolithiasis	5.67155199
3	MP0009278_abnormal_bone_marrow	5.55325668
4	MP0002876_abnormal_thyroid_physiology	5.08198620
5	MP0010234_abnormal_vibrissa_follicle	4.45253774
6	MP0000678_abnormal_parathyroid_gland	3.61684919
7	MP0003941_abnormal_skin_development	3.51256285
8	MP0002796_impaired_skin_barrier	3.07123516
9	MP0001968_abnormal_touch/_nociception	3.06608612
10	MP0004264_abnormal_extraembryonic_tissu	2.85639782
11	MP0005503_abnormal_tendon_morphology	2.75826808
12	MP0003191_abnormal_cellular_cholesterol	2.70984479
13	MP0001664_abnormal_digestion	2.64305508
14	MP0003183_abnormal_peptide_metabolism	2.47379671
15	MP0000681_abnormal_thyroid_gland	2.34024451
16	MP0006035_abnormal_mitochondrial_morpho	2.33875776
17	MP0009764_decreased_sensitivity_to	2.22014015
18	MP0009333_abnormal_splenocyte_physiolog	2.07198320
19	MP0004858_abnormal_nervous_system	2.01095749
20	MP0005501_abnormal_skin_physiology	1.97464229
21	MP0004782_abnormal_surfactant_physiolog	1.88233324
22	MP0005397_hematopoietic_system_phenotyp	1.81419268
23	MP0001545_abnormal_hematopoietic_system	1.81419268
24	MP0003879_abnormal_hair_cell	1.79928355
25	MP0003638_abnormal_response/metabolism_	1.70774408
26	MP0003880_abnormal_central_pattern	1.69820321
27	MP0005646_abnormal_pituitary_gland	1.69700575
28	MP0001666_abnormal_nutrient_absorption	1.61562714
29	MP0003959_abnormal_lean_body	1.60772304
30	MP0002249_abnormal_larynx_morphology	1.60092836
31	MP0003045_fibrosis	1.48671072
32	MP0001501_abnormal_sleep_pattern	1.48550940
33	MP0004147_increased_porphyrin_level	1.43548668
34	MP0001881_abnormal_mammary_gland	1.37335930
35	MP0005645_abnormal_hypothalamus_physiol	1.25829360
36	MP0004019_abnormal_vitamin_homeostasis	1.25419161
37	MP0005551_abnormal_eye_electrophysiolog	1.25144685
38	MP0003950_abnormal_plasma_membrane	1.23175259
39	MP0005085_abnormal_gallbladder_physiolo	1.22252580
40	MP0010771_integument_phenotype	1.21999175
41	MP0010678_abnormal_skin_adnexa	1.16468085
42	MP0005670_abnormal_white_adipose	1.10707900
43	MP0003868_abnormal_feces_composition	1.08187554
44	MP0002098_abnormal_vibrissa_morphology	1.03697832
45	MP0008875_abnormal_xenobiotic_pharmacok	1.03262610
46	MP0002971_abnormal_brown_adipose	1.02686446
47	MP0003567_abnormal_fetal_cardiomyocyte	1.02177054
48	MP0000566_synostosis	1.00371111
49	MP0009672_abnormal_birth_weight	0.99560947
50	MP0009643_abnormal_urine_homeostasis	0.99218427
51	MP0005083_abnormal_biliary_tract	0.98863698
52	MP0002733_abnormal_thermal_nociception	0.97987979
53	MP0000358_abnormal_cell_content/	0.95968880
54	MP0009765_abnormal_xenobiotic_induced	0.94275345
55	MP0008872_abnormal_physiological_respon	0.91262038
56	MP0001756_abnormal_urination	0.87259494
57	MP0003718_maternal_effect	0.84956679
58	MP0008057_abnormal_DNA_replication	0.83902228
59	MP0003633_abnormal_nervous_system	0.82794290
60	MP0005365_abnormal_bile_salt	0.82540692
61	MP0001765_abnormal_ion_homeostasis	0.82236512
62	MP0000538_abnormal_urinary_bladder	0.81821202
63	MP0005332_abnormal_amino_acid	0.81314465
64	MP0003937_abnormal_limbs/digits/tail_de	0.77828924
65	MP0008775_abnormal_heart_ventricle	0.77705401
66	MP0005334_abnormal_fat_pad	0.77135029
67	MP0004233_abnormal_muscle_weight	0.75571813
68	MP0005636_abnormal_mineral_homeostasis	0.71590083
69	MP0000627_abnormal_mammary_gland	0.71546680
70	MP0003806_abnormal_nucleotide_metabolis	0.71430040
71	MP0002139_abnormal_hepatobiliary_system	0.67573116
72	MP0002693_abnormal_pancreas_physiology	0.67434083
73	MP0000749_muscle_degeneration	0.67395260
74	MP0008874_decreased_physiological_sensi	0.66485236
75	MP0003936_abnormal_reproductive_system	0.63578363
76	MP0002168_other_aberrant_phenotype	0.62007367
77	MP0000015_abnormal_ear_pigmentation	0.61711000
78	MP0005451_abnormal_body_composition	0.59265876
79	MP0001270_distended_abdomen	0.59152702
80	MP0001764_abnormal_homeostasis	0.58748895
81	MP0009384_cardiac_valve_regurgitation	0.58239019
82	MP0005395_other_phenotype	0.57573726
83	MP0003693_abnormal_embryo_hatching	0.57144318
84	MP0000230_abnormal_systemic_arterial	0.56674437
85	MP0003195_calcinosis	0.56486069
86	MP0001919_abnormal_reproductive_system	0.54582815
87	MP0005452_abnormal_adipose_tissue	0.54541178
88	MP0000537_abnormal_urethra_morphology	0.53864325
89	MP0010329_abnormal_lipoprotein_level	0.52608903
90	MP0000516_abnormal_urinary_system	0.52273839
91	MP0005367_renal/urinary_system_phenotyp	0.52273839
92	MP0000049_abnormal_middle_ear	0.51730063
93	MP0003953_abnormal_hormone_level	0.50691353
94	MP0009053_abnormal_anal_canal	0.50649302
95	MP0002118_abnormal_lipid_homeostasis	0.48684248
96	MP0002069_abnormal_eating/drinking_beha	0.48139376
97	MP0000383_abnormal_hair_follicle	0.46511863
98	MP0010352_gastrointestinal_tract_polyps	0.45616029
99	MP0002970_abnormal_white_adipose	0.45024067
100	MP0000003_abnormal_adipose_tissue	0.44962889

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	6.42554505
2	Abnormality of the aortic arch (HP:0012303)	6.36788078
3	Intestinal atresia (HP:0011100)	6.16560347
4	Pancreatic islet-cell hyperplasia (HP:0004510)	5.91499923
5	Broad alveolar ridges (HP:0000187)	5.55389954
6	Congenital ichthyosiform erythroderma (HP:0007431)	5.43271151
7	Thickened helices (HP:0000391)	5.29264302
8	Large for gestational age (HP:0001520)	5.14021702
9	Poor head control (HP:0002421)	4.90661875
10	Oligodontia (HP:0000677)	4.82645833
11	Abnormality of endocrine pancreas physiology (HP:0012093)	4.03635552
12	Abnormality of the pancreatic islet cells (HP:0006476)	4.03635552
13	Agitation (HP:0000713)	4.00582249
14	Abnormality of proline metabolism (HP:0010907)	3.93743189
15	Hydroxyprolinuria (HP:0003080)	3.93743189
16	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.89362111
17	Mesangial abnormality (HP:0001966)	3.76798810
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.59401315
19	Abnormality of the ileum (HP:0001549)	3.47465843
20	Pili torti (HP:0003777)	3.42307979
21	Large eyes (HP:0001090)	3.26046672
22	Amelogenesis imperfecta (HP:0000705)	3.20505012
23	Gaze-evoked nystagmus (HP:0000640)	3.16104743
24	Abnormal hair laboratory examination (HP:0003328)	3.12210760
25	Gastrointestinal atresia (HP:0002589)	3.05949236
26	Chromsome breakage (HP:0040012)	3.00298082
27	Hyperpituitarism (HP:0010514)	2.96803887
28	Hypoproteinemia (HP:0003075)	2.94041368
29	Focal motor seizures (HP:0011153)	2.91468427
30	Tented upper lip vermilion (HP:0010804)	2.91061913
31	Tubular atrophy (HP:0000092)	2.89972725
32	Poor speech (HP:0002465)	2.88952488
33	Cerebellar dysplasia (HP:0007033)	2.82456825
34	Abnormality of the alveolar ridges (HP:0006477)	2.80745550
35	Entropion (HP:0000621)	2.74182579
36	Nephroblastoma (Wilms tumor) (HP:0002667)	2.73809156
37	Ileus (HP:0002595)	2.71734090
38	Hyperthyroidism (HP:0000836)	2.63848900
39	Ectropion (HP:0000656)	2.60334054
40	Embryonal renal neoplasm (HP:0011794)	2.55976340
41	Long nose (HP:0003189)	2.35416658
42	Goiter (HP:0000853)	2.34988825
43	Abnormality of macular pigmentation (HP:0008002)	2.33839116
44	Testicular neoplasm (HP:0010788)	2.32825129
45	Type II lissencephaly (HP:0007260)	2.31262921
46	Restlessness (HP:0000711)	2.30839476
47	Central scotoma (HP:0000603)	2.27978032
48	High anterior hairline (HP:0009890)	2.25857735
49	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.23717861
50	Hypoplasia of the brainstem (HP:0002365)	2.23717861
51	Vascular calcification (HP:0004934)	2.22810866
52	Proximal tubulopathy (HP:0000114)	2.16483554
53	Abdominal distention (HP:0003270)	2.14474847
54	Hyperglycinuria (HP:0003108)	2.14295292
55	Hypoplasia of the pons (HP:0012110)	2.12746835
56	Myositis (HP:0100614)	2.09636541
57	Poikiloderma (HP:0001029)	2.09046558
58	Neonatal respiratory distress (HP:0002643)	2.07567797
59	Abnormality of the vitreous humor (HP:0004327)	2.06038017
60	Abnormality of glycine metabolism (HP:0010895)	2.04001467
61	Abnormality of serine family amino acid metabolism (HP:0010894)	2.04001467
62	Late onset (HP:0003584)	2.03910226
63	Hypercortisolism (HP:0001578)	2.02169780
64	Cutaneous melanoma (HP:0012056)	2.01153305
65	Thyroid-stimulating hormone excess (HP:0002925)	13.2435521
66	Hypohidrosis (HP:0000966)	1.99939922
67	Abnormality of liposaccharide metabolism (HP:0010968)	1.99169689
68	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.99169689
69	Abnormality of glycolipid metabolism (HP:0010969)	1.99169689
70	Lissencephaly (HP:0001339)	1.98995487
71	Cone-rod dystrophy (HP:0000548)	1.98551237
72	Abnormality of nail color (HP:0100643)	1.93499997
73	Hyperammonemia (HP:0001987)	1.92717016
74	Optic nerve hypoplasia (HP:0000609)	1.90359850
75	Ketoacidosis (HP:0001993)	1.89981042
76	Scotoma (HP:0000575)	1.89808547
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89507643
78	Orchitis (HP:0100796)	1.89201913
79	Nonprogressive disorder (HP:0003680)	1.89186819
80	Microvesicular hepatic steatosis (HP:0001414)	1.86870528
81	Pigmentary retinal degeneration (HP:0001146)	1.86589320
82	Abnormality of the columella (HP:0009929)	1.84359703
83	Cardiovascular calcification (HP:0011915)	1.80786276
84	Abnormality of the pons (HP:0007361)	1.80521007
85	Septate vagina (HP:0001153)	1.80429648
86	Pendular nystagmus (HP:0012043)	1.74820196
87	Broad-based gait (HP:0002136)	1.72796526
88	Dysdiadochokinesis (HP:0002075)	1.72790541
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72514515
90	Striae distensae (HP:0001065)	1.72463726
91	Attenuation of retinal blood vessels (HP:0007843)	1.69819298
92	Gastrointestinal dysmotility (HP:0002579)	1.69254523
93	Impulsivity (HP:0100710)	1.67642005
94	Severe visual impairment (HP:0001141)	1.65996627
95	Lack of skin elasticity (HP:0100679)	1.64057802
96	Muscular dystrophy (HP:0003560)	1.62146910
97	Horseshoe kidney (HP:0000085)	1.57670736
98	Alopecia of scalp (HP:0002293)	1.56423332
99	Embryonal neoplasm (HP:0002898)	1.54463345
100	Abnormality of magnesium homeostasis (HP:0004921)	1.52624338

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	9.74450939
2	ERN1	5.94426206
3	FRK	3.84262216
4	IRAK3	3.59384568
5	EPHA2	3.51692786
6	PINK1	2.85676940
7	ADRBK1	2.38040867
8	MST1R	2.03362175
9	RIPK1	2.03210278
10	ACVR1B	1.93606934
11	MST4	1.88900355
12	NME2	1.69702655
13	PNCK	1.66421261
14	PRKCG	1.54797891
15	IRAK1	1.50511735
16	PRKCE	1.50072521
17	PRKCI	1.40812127
18	PDK2	1.33028452
19	TYRO3	1.24460677
20	TESK1	1.23339539
21	MAPK11	1.22797927
22	MAP3K12	1.20840998
23	TGFBR1	1.12461737
24	PKN2	1.12143496
25	RPS6KB2	1.11533530
26	TRIM28	1.10856424
27	DYRK3	1.09973177
28	GRK1	1.04909290
29	PBK	1.02788898
30	STK39	1.01521644
31	MAP2K2	1.01493241
32	CLK1	0.99928573
33	MET	0.99593318
34	LIMK1	0.90705845
35	LMTK2	0.89016135
36	NEK1	0.87609979
37	EIF2AK3	0.83422491
38	OXSR1	0.78844927
39	NEK9	0.74851693
40	CAMK2A	0.70428597
41	BRSK1	0.67841331
42	PAK4	0.66940865
43	TRIB3	0.63524698
44	VRK2	0.63352670
45	ERBB2	0.61757055
46	BUB1	0.61734083
47	WEE1	0.61399127
48	MAPKAPK3	0.61086336
49	BRAF	0.59862732
50	EIF2AK1	0.59161560
51	MAP3K8	0.58818469
52	STK10	0.52161881
53	STK38	0.50751535
54	BCKDK	0.50364871
55	MELK	0.47963181
56	TESK2	0.47387981
57	MAP2K1	0.46645296
58	CAMK2D	0.46523602
59	NME1	0.45628664
60	BMPR1B	0.44535078
61	AURKB	0.43876082
62	PTK6	0.43450109
63	TSSK6	0.40527816
64	SCYL2	0.40509569
65	PRKG2	0.37922757
66	CSNK1E	0.37527083
67	PRKCA	0.36203454
68	NEK2	0.35134454
69	STK3	0.34004314
70	PLK2	0.32801813
71	CAMK2G	0.31254703
72	STK38L	0.30809510
73	PIK3CA	0.30620154
74	CSNK1A1L	0.30190005
75	STK16	0.29754919
76	CSNK1A1	0.29487254
77	CSNK2A2	0.29420471
78	MAPKAPK5	0.28507526
79	MYLK	0.28434013
80	GRK6	0.26391706
81	PRKCB	0.25968305
82	ERBB4	0.24343301
83	CDK7	0.24130625
84	FER	0.22628529
85	PDPK1	0.22626501
86	SIK1	0.21631762
87	SIK3	0.21365417
88	CSNK1G3	0.21295488
89	MUSK	0.21246618
90	FLT3	0.20468138
91	AKT2	0.20157392
92	MAPK1	0.20150128
93	TTK	0.19720611
94	AURKA	0.19414328
95	SMG1	0.19328808
96	CAMK4	0.17014506
97	CSNK2A1	0.15643795
98	CAMK1	0.15576785
99	DAPK1	0.15056378
100	GRK5	0.15032568

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.50159408
2	Pentose phosphate pathway_Homo sapiens_hsa00030	2.91618473
3	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.89808130
4	Sulfur relay system_Homo sapiens_hsa04122	2.83888043
5	Sphingolipid metabolism_Homo sapiens_hsa00600	2.48751583
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.39708696
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.15203577
8	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	2.12612736
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.09583028
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07666992
11	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.94724793
12	Fat digestion and absorption_Homo sapiens_hsa04975	1.92401414
13	Glycerolipid metabolism_Homo sapiens_hsa00561	1.90713148
14	Glutathione metabolism_Homo sapiens_hsa00480	1.84595367
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.84204766
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84004072
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.79808747
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.78225919
19	ABC transporters_Homo sapiens_hsa02010	1.70088785
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.61891758
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.61795920
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.57428157
23	Retinol metabolism_Homo sapiens_hsa00830	1.56879673
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.53999327
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.52906957
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.52283452
27	Fatty acid degradation_Homo sapiens_hsa00071	1.51157038
28	Olfactory transduction_Homo sapiens_hsa04740	1.43772203
29	Mineral absorption_Homo sapiens_hsa04978	1.40684801
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.39901811
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.38639089
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.38564102
33	Pancreatic secretion_Homo sapiens_hsa04972	1.36261937
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.35138069
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34830130
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.33954307
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33255704
38	Renin-angiotensin system_Homo sapiens_hsa04614	1.28396755
39	Histidine metabolism_Homo sapiens_hsa00340	1.26431925
40	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.25742003
41	Protein digestion and absorption_Homo sapiens_hsa04974	1.24706736
42	Sulfur metabolism_Homo sapiens_hsa00920	1.21701179
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.21367232
44	Butanoate metabolism_Homo sapiens_hsa00650	1.19072951
45	Arginine and proline metabolism_Homo sapiens_hsa00330	1.12959052
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.12530675
47	Proteasome_Homo sapiens_hsa03050	1.04018245
48	Phototransduction_Homo sapiens_hsa04744	1.02935472
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02184473
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97836665
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96544124
52	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.93134941
53	Carbon metabolism_Homo sapiens_hsa01200	0.92210437
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91248886
55	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.89979590
56	Galactose metabolism_Homo sapiens_hsa00052	0.89738888
57	Metabolic pathways_Homo sapiens_hsa01100	0.84270483
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.82168186
59	Morphine addiction_Homo sapiens_hsa05032	0.79675544
60	Base excision repair_Homo sapiens_hsa03410	0.78243632
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77928312
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77594511
63	Caffeine metabolism_Homo sapiens_hsa00232	0.77119833
64	Complement and coagulation cascades_Homo sapiens_hsa04610	0.75705643
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68734574
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66698342
67	Bile secretion_Homo sapiens_hsa04976	0.66110857
68	Other glycan degradation_Homo sapiens_hsa00511	0.64001123
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.63280785
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.60474938
71	Folate biosynthesis_Homo sapiens_hsa00790	0.58258639
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57252201
73	Peroxisome_Homo sapiens_hsa04146	0.55269891
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.54373562
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53764580
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.52655737
77	Tight junction_Homo sapiens_hsa04530	0.52265726
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52122153
79	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.51670336
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49997079
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48827882
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48805534
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48355539
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47648451
85	PPAR signaling pathway_Homo sapiens_hsa03320	0.47562830
86	Purine metabolism_Homo sapiens_hsa00230	0.47124892
87	Lysosome_Homo sapiens_hsa04142	0.46847722
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.44159823
89	Taste transduction_Homo sapiens_hsa04742	0.41938855
90	Estrogen signaling pathway_Homo sapiens_hsa04915	0.40961973
91	DNA replication_Homo sapiens_hsa03030	0.39237622
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37940915
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.37176219
94	One carbon pool by folate_Homo sapiens_hsa00670	0.35501268
95	Basal transcription factors_Homo sapiens_hsa03022	0.35447420
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.34855649
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.32154419
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31832603
99	RNA transport_Homo sapiens_hsa03013	0.31701701
100	Fatty acid elongation_Homo sapiens_hsa00062	0.31272897

KRT8P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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